
                                SEQUENCE LISTING

<110> The Regents of the University of California
      Salmon, Kirsty
      Roth, David
      Hatfield, G. Wesley
      Dou, Yimeng

<120> XYLOSE- AND ARABINOSE- METABOLIZING
  ENZYME-ENCODING NUCLEOTIDE SEQUENCES WITH REFINED
  TRANSLATIONAL KINETICS AND METHODS OF MAKING SAME
  

<130> UCI005.012VPC

<150> 60/917878           
<151> 2007-05-14  

<150> 60/938901           
<151> 2007-05-18  

<150> 60/938134           
<151> 2007-05-15  

<150> 60/938876           
<151> 2007-05-18  

<150> 60/940348           
<151> 2007-05-25  

<150> 60/939179           
<151> 2007-05-21  

<150> 60/939207          
<151> 2007-05-21

<150> 60/941382           
<151> 2007-06-01

<150> 60/941393          
<151> 2007-06-01

<150> 60/941517         
<151> 2007-06-01

<150> 60/941925          
<151> 2007-06-04

<150> 60/947488         
<151> 2007-07-02

<160> 312

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 957
<212> DNA
<213> P. stipitis

<220> 
<221> CDS            
<222> (1)...(957)

<400> 1
atg cct tct att aag ttg aac tct ggt tac gac atg cca gcc gtc ggt   48
Met Pro Ser Ile Lys Leu Asn Ser Gly Tyr Asp Met Pro Ala Val Gly
 1               5                   10                  15
 
ttc ggc tgt tgg aaa gtc gac gtc gac acc tgt tct gaa cag atc tac   96
Phe Gly Cys Trp Lys Val Asp Val Asp Thr Cys Ser Glu Gln Ile Tyr
             20                  25                  30
 
cgt gct atc aag acc ggt tac aga ttg ttc gac ggt gcc gaa gat tac   144
Arg Ala Ile Lys Thr Gly Tyr Arg Leu Phe Asp Gly Ala Glu Asp Tyr
         35                  40                  45
 
gcc aac gaa aag tta gtt ggt gcc ggt gtc aag aag gcc att gac gaa   192
Ala Asn Glu Lys Leu Val Gly Ala Gly Val Lys Lys Ala Ile Asp Glu
     50                  55                  60
 
ggt atc gtc aag cgt gaa gac ttg ttc ctt acc tcc aag ttg tgg aac   240
Gly Ile Val Lys Arg Glu Asp Leu Phe Leu Thr Ser Lys Leu Trp Asn
 65                  70                  75                  80
 
aac tac cac cac cca gac aac gtc gaa aag gcc ttg aac aga acc ctt   288
Asn Tyr His His Pro Asp Asn Val Glu Lys Ala Leu Asn Arg Thr Leu
                 85                  90                  95
 
tct gac ttg caa gtt gac tac gtt gac ttg ttc ttg atc cac ttc cca   336
Ser Asp Leu Gln Val Asp Tyr Val Asp Leu Phe Leu Ile His Phe Pro
            100                 105                 110
 
gtc acc ttc aag ttc gtt cca tta gaa gaa aag tac cca cca gga ttc   384
Val Thr Phe Lys Phe Val Pro Leu Glu Glu Lys Tyr Pro Pro Gly Phe
        115                 120                 125
 
tac tgt ggt aag ggt gac aac ttc gac tac gaa gat gtt cca att tta   432
Tyr Cys Gly Lys Gly Asp Asn Phe Asp Tyr Glu Asp Val Pro Ile Leu
    130                 135                 140
 
gag acc tgg aag gct ctt gaa aag ttg gtc aag gcc ggt aag atc aga   480
Glu Thr Trp Lys Ala Leu Glu Lys Leu Val Lys Ala Gly Lys Ile Arg
145                 150                 155                 160
 
tct atc ggt gtt tct aac ttc cca ggt gct ttg ctc ttg gac ttg ttg   528
Ser Ile Gly Val Ser Asn Phe Pro Gly Ala Leu Leu Leu Asp Leu Leu
                165                 170                 175
 
aga ggt gct acc atc aag cca tct gtc ttg caa gtt gaa cac cac cca   576
Arg Gly Ala Thr Ile Lys Pro Ser Val Leu Gln Val Glu His His Pro
            180                 185                 190
 
tac ttg caa caa cca aga ttg atc gaa ttc gct caa tcc cgt ggt att   624
Tyr Leu Gln Gln Pro Arg Leu Ile Glu Phe Ala Gln Ser Arg Gly Ile
        195                 200                 205
 
gct gtc acc gct tac tct tcg ttc ggt cct caa tct ttc gtt gaa ttg   672
Ala Val Thr Ala Tyr Ser Ser Phe Gly Pro Gln Ser Phe Val Glu Leu
    210                 215                 220
 
aac caa ggt aga gct ttg aac act tct cca ttg ttc gag aac gaa act   720
Asn Gln Gly Arg Ala Leu Asn Thr Ser Pro Leu Phe Glu Asn Glu Thr
225                 230                 235                 240
 
atc aag gct atc gct gct aag cac ggt aag tct cca gct caa gtc ttg   768
Ile Lys Ala Ile Ala Ala Lys His Gly Lys Ser Pro Ala Gln Val Leu
                245                 250                 255
 
ttg aga tgg tct tcc caa aga ggc att gcc atc att cca aag tcc aac   816
Leu Arg Trp Ser Ser Gln Arg Gly Ile Ala Ile Ile Pro Lys Ser Asn
            260                 265                 270
 
act gtc cca aga ttg ttg gaa aac aag gac gtc aac agc ttc gac ttg   864
Thr Val Pro Arg Leu Leu Glu Asn Lys Asp Val Asn Ser Phe Asp Leu
        275                 280                 285
 
gac gaa caa gat ttc gct gac att gcc aag ttg gac atc aac ttg aga   912
Asp Glu Gln Asp Phe Ala Asp Ile Ala Lys Leu Asp Ile Asn Leu Arg
    290                 295                 300
 
ttc aac gac cca tgg gac tgg gac aag att cct atc ttc gtc taa       957
Phe Asn Asp Pro Trp Asp Trp Asp Lys Ile Pro Ile Phe Val  *
305                 310                 315
 


<210> 2
<211> 318
<212> PRT
<213> P. stipitis

<400> 2
Met Pro Ser Ile Lys Leu Asn Ser Gly Tyr Asp Met Pro Ala Val Gly
 1               5                  10                  15      
Phe Gly Cys Trp Lys Val Asp Val Asp Thr Cys Ser Glu Gln Ile Tyr
            20                  25                  30          
Arg Ala Ile Lys Thr Gly Tyr Arg Leu Phe Asp Gly Ala Glu Asp Tyr
        35                  40                  45              
Ala Asn Glu Lys Leu Val Gly Ala Gly Val Lys Lys Ala Ile Asp Glu
    50                  55                  60                  
Gly Ile Val Lys Arg Glu Asp Leu Phe Leu Thr Ser Lys Leu Trp Asn
65                  70                  75                  80  
Asn Tyr His His Pro Asp Asn Val Glu Lys Ala Leu Asn Arg Thr Leu
                85                  90                  95      
Ser Asp Leu Gln Val Asp Tyr Val Asp Leu Phe Leu Ile His Phe Pro
            100                 105                 110         
Val Thr Phe Lys Phe Val Pro Leu Glu Glu Lys Tyr Pro Pro Gly Phe
        115                 120                 125             
Tyr Cys Gly Lys Gly Asp Asn Phe Asp Tyr Glu Asp Val Pro Ile Leu
    130                 135                 140                 
Glu Thr Trp Lys Ala Leu Glu Lys Leu Val Lys Ala Gly Lys Ile Arg
145                 150                 155                 160 
Ser Ile Gly Val Ser Asn Phe Pro Gly Ala Leu Leu Leu Asp Leu Leu
                165                 170                 175     
Arg Gly Ala Thr Ile Lys Pro Ser Val Leu Gln Val Glu His His Pro
            180                 185                 190         
Tyr Leu Gln Gln Pro Arg Leu Ile Glu Phe Ala Gln Ser Arg Gly Ile
        195                 200                 205             
Ala Val Thr Ala Tyr Ser Ser Phe Gly Pro Gln Ser Phe Val Glu Leu
    210                 215                 220                 
Asn Gln Gly Arg Ala Leu Asn Thr Ser Pro Leu Phe Glu Asn Glu Thr
225                 230                 235                 240 
Ile Lys Ala Ile Ala Ala Lys His Gly Lys Ser Pro Ala Gln Val Leu
                245                 250                 255     
Leu Arg Trp Ser Ser Gln Arg Gly Ile Ala Ile Ile Pro Lys Ser Asn
            260                 265                 270         
Thr Val Pro Arg Leu Leu Glu Asn Lys Asp Val Asn Ser Phe Asp Leu
        275                 280                 285             
Asp Glu Gln Asp Phe Ala Asp Ile Ala Lys Leu Asp Ile Asn Leu Arg
    290                 295                 300                 
Phe Asn Asp Pro Trp Asp Trp Asp Lys Ile Pro Ile Phe Val
305                 310                 315             


<210> 3
<211> 954
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in S. cerevisiae

<220> 
<221> CDS            
<222> (1)...(954)

<400> 3
atg cca tct att aaa tta aat tca ggt tat gat atg cca gct gtt ggt   48
Met Pro Ser Ile Lys Leu Asn Ser Gly Tyr Asp Met Pro Ala Val Gly
 1               5                   10                  15
 
ttt gga tgt tgg aaa gta gat gtt gat act tgt tct gaa caa att tat   96
Phe Gly Cys Trp Lys Val Asp Val Asp Thr Cys Ser Glu Gln Ile Tyr
             20                  25                  30
 
aga gct att aaa act ggt tat aga ttg ttt gat ggt gct gaa gat tat   144
Arg Ala Ile Lys Thr Gly Tyr Arg Leu Phe Asp Gly Ala Glu Asp Tyr
         35                  40                  45
 
gct aat gaa aaa ttg gta gga gct ggt gtt aaa aag gct att gat gaa   192
Ala Asn Glu Lys Leu Val Gly Ala Gly Val Lys Lys Ala Ile Asp Glu
     50                  55                  60
 
gga att gtt aaa aga gaa gat ttg ttt ttg act tct aaa ttg tgg aat   240
Gly Ile Val Lys Arg Glu Asp Leu Phe Leu Thr Ser Lys Leu Trp Asn
 65                  70                  75                  80
 
aat tat cat cat cca gat aat gtt gaa aaa gct cta aat aga act cta   288
Asn Tyr His His Pro Asp Asn Val Glu Lys Ala Leu Asn Arg Thr Leu
                 85                  90                  95
 
tct gat ttg caa gta gat tat gtt gac ttg ttt ttg att cat ttt cca   336
Ser Asp Leu Gln Val Asp Tyr Val Asp Leu Phe Leu Ile His Phe Pro
            100                 105                 110
 
gtt act ttt aaa ttc gtt cca ttg gaa gaa aaa tat cct cct ggt ttt   384
Val Thr Phe Lys Phe Val Pro Leu Glu Glu Lys Tyr Pro Pro Gly Phe
        115                 120                 125
 
tat tgt ggt aaa ggt gat aat ttt gat tat gaa gat gtt cct ata ttg   432
Tyr Cys Gly Lys Gly Asp Asn Phe Asp Tyr Glu Asp Val Pro Ile Leu
    130                 135                 140
 
gaa act tgg aaa gct cta gaa aaa ttg gtt aaa gct ggt aaa att aga   480
Glu Thr Trp Lys Ala Leu Glu Lys Leu Val Lys Ala Gly Lys Ile Arg
145                 150                 155                 160
 
tct att ggt gtt tca aat ttt cca ggt gct ttg ttg ttg gat ttg ttg   528
Ser Ile Gly Val Ser Asn Phe Pro Gly Ala Leu Leu Leu Asp Leu Leu
                165                 170                 175
 
aga ggt gct aca att aaa cca tct gtt ttg caa gtt gaa cat cat cca   576
Arg Gly Ala Thr Ile Lys Pro Ser Val Leu Gln Val Glu His His Pro
            180                 185                 190
 
tat ttg caa caa cct aga tta att gaa ttt gct caa tct aga gga att   624
Tyr Leu Gln Gln Pro Arg Leu Ile Glu Phe Ala Gln Ser Arg Gly Ile
        195                 200                 205
 
gct gtt act gct tat tct tct ttt gga cca caa tct ttt gta gaa tta   672
Ala Val Thr Ala Tyr Ser Ser Phe Gly Pro Gln Ser Phe Val Glu Leu
    210                 215                 220
 
aat caa ggt aga gct tta aat act tca cca ttg ttt gaa aat gaa act   720
Asn Gln Gly Arg Ala Leu Asn Thr Ser Pro Leu Phe Glu Asn Glu Thr
225                 230                 235                 240
 
att aag gct att gct gct aaa cac ggt aaa tca cca gca cag gta tta   768
Ile Lys Ala Ile Ala Ala Lys His Gly Lys Ser Pro Ala Gln Val Leu
                245                 250                 255
 
tta aga tgg tca tca caa aga gga atc gct att att cca aaa tct aat   816
Leu Arg Trp Ser Ser Gln Arg Gly Ile Ala Ile Ile Pro Lys Ser Asn
            260                 265                 270
 
act gtt cct cgt ttg ttg gaa aat aaa gat gtt aat tct ttt gat ttg   864
Thr Val Pro Arg Leu Leu Glu Asn Lys Asp Val Asn Ser Phe Asp Leu
        275                 280                 285
 
gat gaa caa gat ttt gct gat ata gct aaa ttg gac att aat ttg aga   912
Asp Glu Gln Asp Phe Ala Asp Ile Ala Lys Leu Asp Ile Asn Leu Arg
    290                 295                 300
 
ttt aat gat cct tgg gat tgg gat aaa att cca att ttt gta           954
Phe Asn Asp Pro Trp Asp Trp Asp Lys Ile Pro Ile Phe Val
305                 310                 315
 


<210> 4
<211> 318
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in S. cerevisiae

<400> 4
Met Pro Ser Ile Lys Leu Asn Ser Gly Tyr Asp Met Pro Ala Val Gly
 1               5                  10                  15      
Phe Gly Cys Trp Lys Val Asp Val Asp Thr Cys Ser Glu Gln Ile Tyr
            20                  25                  30          
Arg Ala Ile Lys Thr Gly Tyr Arg Leu Phe Asp Gly Ala Glu Asp Tyr
        35                  40                  45              
Ala Asn Glu Lys Leu Val Gly Ala Gly Val Lys Lys Ala Ile Asp Glu
    50                  55                  60                  
Gly Ile Val Lys Arg Glu Asp Leu Phe Leu Thr Ser Lys Leu Trp Asn
65                  70                  75                  80  
Asn Tyr His His Pro Asp Asn Val Glu Lys Ala Leu Asn Arg Thr Leu
                85                  90                  95      
Ser Asp Leu Gln Val Asp Tyr Val Asp Leu Phe Leu Ile His Phe Pro
            100                 105                 110         
Val Thr Phe Lys Phe Val Pro Leu Glu Glu Lys Tyr Pro Pro Gly Phe
        115                 120                 125             
Tyr Cys Gly Lys Gly Asp Asn Phe Asp Tyr Glu Asp Val Pro Ile Leu
    130                 135                 140                 
Glu Thr Trp Lys Ala Leu Glu Lys Leu Val Lys Ala Gly Lys Ile Arg
145                 150                 155                 160 
Ser Ile Gly Val Ser Asn Phe Pro Gly Ala Leu Leu Leu Asp Leu Leu
                165                 170                 175     
Arg Gly Ala Thr Ile Lys Pro Ser Val Leu Gln Val Glu His His Pro
            180                 185                 190         
Tyr Leu Gln Gln Pro Arg Leu Ile Glu Phe Ala Gln Ser Arg Gly Ile
        195                 200                 205             
Ala Val Thr Ala Tyr Ser Ser Phe Gly Pro Gln Ser Phe Val Glu Leu
    210                 215                 220                 
Asn Gln Gly Arg Ala Leu Asn Thr Ser Pro Leu Phe Glu Asn Glu Thr
225                 230                 235                 240 
Ile Lys Ala Ile Ala Ala Lys His Gly Lys Ser Pro Ala Gln Val Leu
                245                 250                 255     
Leu Arg Trp Ser Ser Gln Arg Gly Ile Ala Ile Ile Pro Lys Ser Asn
            260                 265                 270         
Thr Val Pro Arg Leu Leu Glu Asn Lys Asp Val Asn Ser Phe Asp Leu
        275                 280                 285             
Asp Glu Gln Asp Phe Ala Asp Ile Ala Lys Leu Asp Ile Asn Leu Arg
    290                 295                 300                 
Phe Asn Asp Pro Trp Asp Trp Asp Lys Ile Pro Ile Phe Val
305                 310                 315             


<210> 5
<211> 976
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in S. cerevisiae

<220> 
<221> CDS            
<222> (12)...(965)

<400> 5
tactcaagct t atg cca tct att aaa tta aat tca ggt tat gat atg cca  50
             Met Pro Ser Ile Lys Leu Asn Ser Gly Tyr Asp Met Pro
              1               5                   10
 
gct gtt ggt ttt gga tgt tgg aaa gta gat gtt gat act tgt tct gaa   98
Ala Val Gly Phe Gly Cys Trp Lys Val Asp Val Asp Thr Cys Ser Glu
     15                  20                  25
 
caa att tat aga gct att aaa act ggt tat aga ttg ttt gat ggt gct   146
Gln Ile Tyr Arg Ala Ile Lys Thr Gly Tyr Arg Leu Phe Asp Gly Ala
 30                  35                  40                  45
 
gaa gat tat gct aat gaa aaa ttg gta gga gct ggt gtt aaa aag gct   194
Glu Asp Tyr Ala Asn Glu Lys Leu Val Gly Ala Gly Val Lys Lys Ala
                 50                  55                  60
 
att gat gaa gga att gtt aaa aga gaa gat ttg ttt ttg act tct aaa   242
Ile Asp Glu Gly Ile Val Lys Arg Glu Asp Leu Phe Leu Thr Ser Lys
             65                  70                  75
 
ttg tgg aat aat tat cat cat cca gat aat gtt gaa aaa gct cta aat   290
Leu Trp Asn Asn Tyr His His Pro Asp Asn Val Glu Lys Ala Leu Asn
         80                  85                  90
 
aga act cta tct gat ttg caa gta gat tat gtt gac ttg ttt ttg att   338
Arg Thr Leu Ser Asp Leu Gln Val Asp Tyr Val Asp Leu Phe Leu Ile
     95                 100                 105
 
cat ttt cca gtt act ttt aaa ttc gtt cca ttg gaa gaa aaa tat cct   386
His Phe Pro Val Thr Phe Lys Phe Val Pro Leu Glu Glu Lys Tyr Pro
110                 115                 120                 125
 
cct ggt ttt tat tgt ggt aaa ggt gat aat ttt gat tat gaa gat gtt   434
Pro Gly Phe Tyr Cys Gly Lys Gly Asp Asn Phe Asp Tyr Glu Asp Val
                130                 135                 140
 
cct ata ttg gaa act tgg aaa gct cta gaa aaa ttg gtt aaa gct ggt   482
Pro Ile Leu Glu Thr Trp Lys Ala Leu Glu Lys Leu Val Lys Ala Gly
            145                 150                 155
 
aaa att aga tct att ggt gtt tca aat ttt cca ggt gct ttg ttg ttg   530
Lys Ile Arg Ser Ile Gly Val Ser Asn Phe Pro Gly Ala Leu Leu Leu
        160                 165                 170
 
gat ttg ttg aga ggt gct aca att aaa cca tct gtt ttg caa gtt gaa   578
Asp Leu Leu Arg Gly Ala Thr Ile Lys Pro Ser Val Leu Gln Val Glu
    175                 180                 185
 
cat cat cca tat ttg caa caa cct aga tta att gaa ttt gct caa tct   626
His His Pro Tyr Leu Gln Gln Pro Arg Leu Ile Glu Phe Ala Gln Ser
190                 195                 200                 205
 
aga gga att gct gtt act gct tat tct tct ttt gga cca caa tct ttt   674
Arg Gly Ile Ala Val Thr Ala Tyr Ser Ser Phe Gly Pro Gln Ser Phe
                210                 215                 220
 
gta gaa tta aat caa ggt aga gct tta aat act tca cca ttg ttt gaa   722
Val Glu Leu Asn Gln Gly Arg Ala Leu Asn Thr Ser Pro Leu Phe Glu
            225                 230                 235
 
aat gaa act att aag gct att gct gct aaa cac ggt aaa tca cca gca   770
Asn Glu Thr Ile Lys Ala Ile Ala Ala Lys His Gly Lys Ser Pro Ala
        240                 245                 250
 
cag gta tta tta aga tgg tca tca caa aga gga atc gct att att cca   818
Gln Val Leu Leu Arg Trp Ser Ser Gln Arg Gly Ile Ala Ile Ile Pro
    255                 260                 265
 
aaa tct aat act gtt cct cgt ttg ttg gaa aat aaa gat gtt aat tct   866
Lys Ser Asn Thr Val Pro Arg Leu Leu Glu Asn Lys Asp Val Asn Ser
270                 275                 280                 285
 
ttt gat ttg gat gaa caa gat ttt gct gat ata gct aaa ttg gac att   914
Phe Asp Leu Asp Glu Gln Asp Phe Ala Asp Ile Ala Lys Leu Asp Ile
                290                 295                 300
 
aat ttg aga ttt aat gat cct tgg gat tgg gat aaa att cca att ttt   962
Asn Leu Arg Phe Asn Asp Pro Trp Asp Trp Asp Lys Ile Pro Ile Phe
            305                 310                 315
 
gta gaattccgat g                                                  976
Val

 

<210> 6
<211> 318
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in S. cerevisiae

<400> 6
Met Pro Ser Ile Lys Leu Asn Ser Gly Tyr Asp Met Pro Ala Val Gly
 1               5                  10                  15      
Phe Gly Cys Trp Lys Val Asp Val Asp Thr Cys Ser Glu Gln Ile Tyr
            20                  25                  30          
Arg Ala Ile Lys Thr Gly Tyr Arg Leu Phe Asp Gly Ala Glu Asp Tyr
        35                  40                  45              
Ala Asn Glu Lys Leu Val Gly Ala Gly Val Lys Lys Ala Ile Asp Glu
    50                  55                  60                  
Gly Ile Val Lys Arg Glu Asp Leu Phe Leu Thr Ser Lys Leu Trp Asn
65                  70                  75                  80  
Asn Tyr His His Pro Asp Asn Val Glu Lys Ala Leu Asn Arg Thr Leu
                85                  90                  95      
Ser Asp Leu Gln Val Asp Tyr Val Asp Leu Phe Leu Ile His Phe Pro
            100                 105                 110         
Val Thr Phe Lys Phe Val Pro Leu Glu Glu Lys Tyr Pro Pro Gly Phe
        115                 120                 125             
Tyr Cys Gly Lys Gly Asp Asn Phe Asp Tyr Glu Asp Val Pro Ile Leu
    130                 135                 140                 
Glu Thr Trp Lys Ala Leu Glu Lys Leu Val Lys Ala Gly Lys Ile Arg
145                 150                 155                 160 
Ser Ile Gly Val Ser Asn Phe Pro Gly Ala Leu Leu Leu Asp Leu Leu
                165                 170                 175     
Arg Gly Ala Thr Ile Lys Pro Ser Val Leu Gln Val Glu His His Pro
            180                 185                 190         
Tyr Leu Gln Gln Pro Arg Leu Ile Glu Phe Ala Gln Ser Arg Gly Ile
        195                 200                 205             
Ala Val Thr Ala Tyr Ser Ser Phe Gly Pro Gln Ser Phe Val Glu Leu
    210                 215                 220                 
Asn Gln Gly Arg Ala Leu Asn Thr Ser Pro Leu Phe Glu Asn Glu Thr
225                 230                 235                 240 
Ile Lys Ala Ile Ala Ala Lys His Gly Lys Ser Pro Ala Gln Val Leu
                245                 250                 255     
Leu Arg Trp Ser Ser Gln Arg Gly Ile Ala Ile Ile Pro Lys Ser Asn
            260                 265                 270         
Thr Val Pro Arg Leu Leu Glu Asn Lys Asp Val Asn Ser Phe Asp Leu
        275                 280                 285             
Asp Glu Gln Asp Phe Ala Asp Ile Ala Lys Leu Asp Ile Asn Leu Arg
    290                 295                 300                 
Phe Asn Asp Pro Trp Asp Trp Asp Lys Ile Pro Ile Phe Val
305                 310                 315             


<210> 7
<211> 982
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in S. cerevisiae

<220> 
<221> CDS            
<222> (15)...(968)

<400> 7
gaatactcca tatg atg cca tct att aaa tta aat tca ggt tat gat atg   50
                Met Pro Ser Ile Lys Leu Asn Ser Gly Tyr Asp Met
                 1               5                   10
 
cca gct gtt ggt ttt gga tgt tgg aaa gta gat gtt gat act tgt tct   98
Pro Ala Val Gly Phe Gly Cys Trp Lys Val Asp Val Asp Thr Cys Ser
         15                  20                  25
 
gaa caa att tat aga gct att aaa act ggt tat aga ttg ttt gat ggt   146
Glu Gln Ile Tyr Arg Ala Ile Lys Thr Gly Tyr Arg Leu Phe Asp Gly
     30                  35                  40
 
gct gaa gat tat gct aat gaa aaa ttg gta gga gct ggt gtt aaa aag   194
Ala Glu Asp Tyr Ala Asn Glu Lys Leu Val Gly Ala Gly Val Lys Lys
 45                  50                  55                  60
 
gct att gat gaa gga att gtt aaa aga gaa gat ttg ttt ttg act tct   242
Ala Ile Asp Glu Gly Ile Val Lys Arg Glu Asp Leu Phe Leu Thr Ser
                 65                  70                  75
 
aaa ttg tgg aat aat tat cat cat cca gat aat gtt gaa aaa gct cta   290
Lys Leu Trp Asn Asn Tyr His His Pro Asp Asn Val Glu Lys Ala Leu
             80                  85                  90
 
aat aga act cta tct gat ttg caa gta gat tat gtt gac ttg ttt ttg   338
Asn Arg Thr Leu Ser Asp Leu Gln Val Asp Tyr Val Asp Leu Phe Leu
         95                 100                 105
 
att cat ttt cca gtt act ttt aaa ttc gtt cca ttg gaa gaa aaa tat   386
Ile His Phe Pro Val Thr Phe Lys Phe Val Pro Leu Glu Glu Lys Tyr
    110                 115                 120
 
cct cct ggt ttt tat tgt ggt aaa ggt gat aat ttt gat tat gaa gat   434
Pro Pro Gly Phe Tyr Cys Gly Lys Gly Asp Asn Phe Asp Tyr Glu Asp
125                 130                 135                 140
 
gtt cct ata ttg gaa act tgg aaa gct cta gaa aaa ttg gtt aaa gct   482
Val Pro Ile Leu Glu Thr Trp Lys Ala Leu Glu Lys Leu Val Lys Ala
                145                 150                 155
 
ggt aaa att aga tct att ggt gtt tca aat ttt cca ggt gct ttg ttg   530
Gly Lys Ile Arg Ser Ile Gly Val Ser Asn Phe Pro Gly Ala Leu Leu
            160                 165                 170
 
ttg gat ttg ttg aga ggt gct aca att aaa cca tct gtt ttg caa gtt   578
Leu Asp Leu Leu Arg Gly Ala Thr Ile Lys Pro Ser Val Leu Gln Val
        175                 180                 185
 
gaa cat cat cca tat ttg caa caa cct aga tta att gaa ttt gct caa   626
Glu His His Pro Tyr Leu Gln Gln Pro Arg Leu Ile Glu Phe Ala Gln
    190                 195                 200
 
tct aga gga att gct gtt act gct tat tct tct ttt gga cca caa tct   674
Ser Arg Gly Ile Ala Val Thr Ala Tyr Ser Ser Phe Gly Pro Gln Ser
205                 210                 215                 220
 
ttt gta gaa tta aat caa ggt aga gct tta aat act tca cca ttg ttt   722
Phe Val Glu Leu Asn Gln Gly Arg Ala Leu Asn Thr Ser Pro Leu Phe
                225                 230                 235
 
gaa aat gaa act att aag gct att gct gct aaa cac ggt aaa tca cca   770
Glu Asn Glu Thr Ile Lys Ala Ile Ala Ala Lys His Gly Lys Ser Pro
            240                 245                 250
 
gca cag gta tta tta aga tgg tca tca caa aga gga atc gct att att   818
Ala Gln Val Leu Leu Arg Trp Ser Ser Gln Arg Gly Ile Ala Ile Ile
        255                 260                 265
 
cca aaa tct aat act gtt cct cgt ttg ttg gaa aat aaa gat gtt aat   866
Pro Lys Ser Asn Thr Val Pro Arg Leu Leu Glu Asn Lys Asp Val Asn
    270                 275                 280
 
tct ttt gat ttg gat gaa caa gat ttt gct gat ata gct aaa ttg gac   914
Ser Phe Asp Leu Asp Glu Gln Asp Phe Ala Asp Ile Ala Lys Leu Asp
285                 290                 295                 300
 
att aat ttg aga ttt aat gat cct tgg gat tgg gat aaa att cca att   962
Ile Asn Leu Arg Phe Asn Asp Pro Trp Asp Trp Asp Lys Ile Pro Ile
                305                 310                 315
 
ttt gta actagtcgat gcct                                           982
Phe Val

 

<210> 8
<211> 318
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in S. cerevisiae

<400> 8
Met Pro Ser Ile Lys Leu Asn Ser Gly Tyr Asp Met Pro Ala Val Gly
 1               5                  10                  15      
Phe Gly Cys Trp Lys Val Asp Val Asp Thr Cys Ser Glu Gln Ile Tyr
            20                  25                  30          
Arg Ala Ile Lys Thr Gly Tyr Arg Leu Phe Asp Gly Ala Glu Asp Tyr
        35                  40                  45              
Ala Asn Glu Lys Leu Val Gly Ala Gly Val Lys Lys Ala Ile Asp Glu
    50                  55                  60                  
Gly Ile Val Lys Arg Glu Asp Leu Phe Leu Thr Ser Lys Leu Trp Asn
65                  70                  75                  80  
Asn Tyr His His Pro Asp Asn Val Glu Lys Ala Leu Asn Arg Thr Leu
                85                  90                  95      
Ser Asp Leu Gln Val Asp Tyr Val Asp Leu Phe Leu Ile His Phe Pro
            100                 105                 110         
Val Thr Phe Lys Phe Val Pro Leu Glu Glu Lys Tyr Pro Pro Gly Phe
        115                 120                 125             
Tyr Cys Gly Lys Gly Asp Asn Phe Asp Tyr Glu Asp Val Pro Ile Leu
    130                 135                 140                 
Glu Thr Trp Lys Ala Leu Glu Lys Leu Val Lys Ala Gly Lys Ile Arg
145                 150                 155                 160 
Ser Ile Gly Val Ser Asn Phe Pro Gly Ala Leu Leu Leu Asp Leu Leu
                165                 170                 175     
Arg Gly Ala Thr Ile Lys Pro Ser Val Leu Gln Val Glu His His Pro
            180                 185                 190         
Tyr Leu Gln Gln Pro Arg Leu Ile Glu Phe Ala Gln Ser Arg Gly Ile
        195                 200                 205             
Ala Val Thr Ala Tyr Ser Ser Phe Gly Pro Gln Ser Phe Val Glu Leu
    210                 215                 220                 
Asn Gln Gly Arg Ala Leu Asn Thr Ser Pro Leu Phe Glu Asn Glu Thr
225                 230                 235                 240 
Ile Lys Ala Ile Ala Ala Lys His Gly Lys Ser Pro Ala Gln Val Leu
                245                 250                 255     
Leu Arg Trp Ser Ser Gln Arg Gly Ile Ala Ile Ile Pro Lys Ser Asn
            260                 265                 270         
Thr Val Pro Arg Leu Leu Glu Asn Lys Asp Val Asn Ser Phe Asp Leu
        275                 280                 285             
Asp Glu Gln Asp Phe Ala Asp Ile Ala Lys Leu Asp Ile Asn Leu Arg
    290                 295                 300                 
Phe Asn Asp Pro Trp Asp Trp Asp Lys Ile Pro Ile Phe Val
305                 310                 315             


<210> 9
<211> 954
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in E. coli

<220> 
<221> CDS            
<222> (1)...(954)

<400> 9
atg cca tct att aaa tta aat tca ggt tat gat atg cca gct gtt ggt   48
Met Pro Ser Ile Lys Leu Asn Ser Gly Tyr Asp Met Pro Ala Val Gly
 1               5                   10                  15
 
ttt gga tgt tgg aaa gta gat gtt gat act tgt tct gaa caa att tat   96
Phe Gly Cys Trp Lys Val Asp Val Asp Thr Cys Ser Glu Gln Ile Tyr
             20                  25                  30
 
aga gct att aaa act ggt tat aga ttg ttt gat ggt gct gaa gat tat   144
Arg Ala Ile Lys Thr Gly Tyr Arg Leu Phe Asp Gly Ala Glu Asp Tyr
         35                  40                  45
 
gct aat gaa aaa ttg gta gga gct ggt gtt aaa aag gct att gat gaa   192
Ala Asn Glu Lys Leu Val Gly Ala Gly Val Lys Lys Ala Ile Asp Glu
     50                  55                  60
 
gga att gtt aaa aga gaa gat ttg ttt ttg act tct aaa ttg tgg aat   240
Gly Ile Val Lys Arg Glu Asp Leu Phe Leu Thr Ser Lys Leu Trp Asn
 65                  70                  75                  80
 
aat tat cat cat cca gat aat gtt gaa aaa gct cta aat aga act cta   288
Asn Tyr His His Pro Asp Asn Val Glu Lys Ala Leu Asn Arg Thr Leu
                 85                  90                  95
 
tct gat ttg caa gta gat tat gtt gac ttg ttt ttg att cat ttt cca   336
Ser Asp Leu Gln Val Asp Tyr Val Asp Leu Phe Leu Ile His Phe Pro
            100                 105                 110
 
gtt act ttt aaa ttc gtt cca ttg gaa gaa aaa tat cct cct ggt ttt   384
Val Thr Phe Lys Phe Val Pro Leu Glu Glu Lys Tyr Pro Pro Gly Phe
        115                 120                 125
 
tat tgt ggt aaa ggt gat aat ttt gat tat gaa gat gtt cct ata ttg   432
Tyr Cys Gly Lys Gly Asp Asn Phe Asp Tyr Glu Asp Val Pro Ile Leu
    130                 135                 140
 
gaa act tgg aaa gct cta gaa aaa ttg gtt aaa gct ggt aaa att aga   480
Glu Thr Trp Lys Ala Leu Glu Lys Leu Val Lys Ala Gly Lys Ile Arg
145                 150                 155                 160
 
tct att ggt gtt tca aat ttt cca ggt gct ttg ttg ttg gat ttg ttg   528
Ser Ile Gly Val Ser Asn Phe Pro Gly Ala Leu Leu Leu Asp Leu Leu
                165                 170                 175
 
aga ggt gct aca att aaa cca tct gtt ttg caa gtt gaa cat cat cca   576
Arg Gly Ala Thr Ile Lys Pro Ser Val Leu Gln Val Glu His His Pro
            180                 185                 190
 
tat ttg caa caa cct aga tta att gaa ttt gct caa tct aga gga att   624
Tyr Leu Gln Gln Pro Arg Leu Ile Glu Phe Ala Gln Ser Arg Gly Ile
        195                 200                 205
 
gct gtt act gct tat tct tct ttt gga cca caa tct ttt gta gaa tta   672
Ala Val Thr Ala Tyr Ser Ser Phe Gly Pro Gln Ser Phe Val Glu Leu
    210                 215                 220
 
aat caa ggt aga gct tta aat act tca cca ttg ttt gaa aat gaa act   720
Asn Gln Gly Arg Ala Leu Asn Thr Ser Pro Leu Phe Glu Asn Glu Thr
225                 230                 235                 240
 
att aag gct att gct gct aaa cac ggt aaa tca cca gca cag gta tta   768
Ile Lys Ala Ile Ala Ala Lys His Gly Lys Ser Pro Ala Gln Val Leu
                245                 250                 255
 
tta aga tgg tca tca caa aga gga atc gct att att cca aaa tct aat   816
Leu Arg Trp Ser Ser Gln Arg Gly Ile Ala Ile Ile Pro Lys Ser Asn
            260                 265                 270
 
act gtt cct cgt ttg ttg gaa aat aaa gat gtt aat tct ttt gat ttg   864
Thr Val Pro Arg Leu Leu Glu Asn Lys Asp Val Asn Ser Phe Asp Leu
        275                 280                 285
 
gat gaa caa gat ttt gct gat ata gct aaa ttg gac att aat ttg aga   912
Asp Glu Gln Asp Phe Ala Asp Ile Ala Lys Leu Asp Ile Asn Leu Arg
    290                 295                 300
 
ttt aat gat cct tgg gat tgg gat aaa att cca att ttt gta           954
Phe Asn Asp Pro Trp Asp Trp Asp Lys Ile Pro Ile Phe Val
305                 310                 315
 


<210> 10
<211> 318
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in E. coli

<400> 10
Met Pro Ser Ile Lys Leu Asn Ser Gly Tyr Asp Met Pro Ala Val Gly
 1               5                  10                  15      
Phe Gly Cys Trp Lys Val Asp Val Asp Thr Cys Ser Glu Gln Ile Tyr
            20                  25                  30          
Arg Ala Ile Lys Thr Gly Tyr Arg Leu Phe Asp Gly Ala Glu Asp Tyr
        35                  40                  45              
Ala Asn Glu Lys Leu Val Gly Ala Gly Val Lys Lys Ala Ile Asp Glu
    50                  55                  60                  
Gly Ile Val Lys Arg Glu Asp Leu Phe Leu Thr Ser Lys Leu Trp Asn
65                  70                  75                  80  
Asn Tyr His His Pro Asp Asn Val Glu Lys Ala Leu Asn Arg Thr Leu
                85                  90                  95      
Ser Asp Leu Gln Val Asp Tyr Val Asp Leu Phe Leu Ile His Phe Pro
            100                 105                 110         
Val Thr Phe Lys Phe Val Pro Leu Glu Glu Lys Tyr Pro Pro Gly Phe
        115                 120                 125             
Tyr Cys Gly Lys Gly Asp Asn Phe Asp Tyr Glu Asp Val Pro Ile Leu
    130                 135                 140                 
Glu Thr Trp Lys Ala Leu Glu Lys Leu Val Lys Ala Gly Lys Ile Arg
145                 150                 155                 160 
Ser Ile Gly Val Ser Asn Phe Pro Gly Ala Leu Leu Leu Asp Leu Leu
                165                 170                 175     
Arg Gly Ala Thr Ile Lys Pro Ser Val Leu Gln Val Glu His His Pro
            180                 185                 190         
Tyr Leu Gln Gln Pro Arg Leu Ile Glu Phe Ala Gln Ser Arg Gly Ile
        195                 200                 205             
Ala Val Thr Ala Tyr Ser Ser Phe Gly Pro Gln Ser Phe Val Glu Leu
    210                 215                 220                 
Asn Gln Gly Arg Ala Leu Asn Thr Ser Pro Leu Phe Glu Asn Glu Thr
225                 230                 235                 240 
Ile Lys Ala Ile Ala Ala Lys His Gly Lys Ser Pro Ala Gln Val Leu
                245                 250                 255     
Leu Arg Trp Ser Ser Gln Arg Gly Ile Ala Ile Ile Pro Lys Ser Asn
            260                 265                 270         
Thr Val Pro Arg Leu Leu Glu Asn Lys Asp Val Asn Ser Phe Asp Leu
        275                 280                 285             
Asp Glu Gln Asp Phe Ala Asp Ile Ala Lys Leu Asp Ile Asn Leu Arg
    290                 295                 300                 
Phe Asn Asp Pro Trp Asp Trp Asp Lys Ile Pro Ile Phe Val
305                 310                 315             


<210> 11
<211> 976
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in E. coli

<220> 
<221> CDS            
<222> (12)...(965)

<400> 11
tactcaagct t atg cca tct att aaa tta aat tca ggt tat gat atg cca  50
             Met Pro Ser Ile Lys Leu Asn Ser Gly Tyr Asp Met Pro
              1               5                   10
 
gct gtt ggt ttt gga tgt tgg aaa gta gat gtt gat act tgt tct gaa   98
Ala Val Gly Phe Gly Cys Trp Lys Val Asp Val Asp Thr Cys Ser Glu
     15                  20                  25
 
caa att tat aga gct att aaa act ggt tat aga ttg ttt gat ggt gct   146
Gln Ile Tyr Arg Ala Ile Lys Thr Gly Tyr Arg Leu Phe Asp Gly Ala
 30                  35                  40                  45
 
gaa gat tat gct aat gaa aaa ttg gta gga gct ggt gtt aaa aag gct   194
Glu Asp Tyr Ala Asn Glu Lys Leu Val Gly Ala Gly Val Lys Lys Ala
                 50                  55                  60
 
att gat gaa gga att gtt aaa aga gaa gat ttg ttt ttg act tct aaa   242
Ile Asp Glu Gly Ile Val Lys Arg Glu Asp Leu Phe Leu Thr Ser Lys
             65                  70                  75
 
ttg tgg aat aat tat cat cat cca gat aat gtt gaa aaa gct cta aat   290
Leu Trp Asn Asn Tyr His His Pro Asp Asn Val Glu Lys Ala Leu Asn
         80                  85                  90
 
aga act cta tct gat ttg caa gta gat tat gtt gac ttg ttt ttg att   338
Arg Thr Leu Ser Asp Leu Gln Val Asp Tyr Val Asp Leu Phe Leu Ile
     95                 100                 105
 
cat ttt cca gtt act ttt aaa ttc gtt cca ttg gaa gaa aaa tat cct   386
His Phe Pro Val Thr Phe Lys Phe Val Pro Leu Glu Glu Lys Tyr Pro
110                 115                 120                 125
 
cct ggt ttt tat tgt ggt aaa ggt gat aat ttt gat tat gaa gat gtt   434
Pro Gly Phe Tyr Cys Gly Lys Gly Asp Asn Phe Asp Tyr Glu Asp Val
                130                 135                 140
 
cct ata ttg gaa act tgg aaa gct cta gaa aaa ttg gtt aaa gct ggt   482
Pro Ile Leu Glu Thr Trp Lys Ala Leu Glu Lys Leu Val Lys Ala Gly
            145                 150                 155
 
aaa att aga tct att ggt gtt tca aat ttt cca ggt gct ttg ttg ttg   530
Lys Ile Arg Ser Ile Gly Val Ser Asn Phe Pro Gly Ala Leu Leu Leu
        160                 165                 170
 
gat ttg ttg aga ggt gct aca att aaa cca tct gtt ttg caa gtt gaa   578
Asp Leu Leu Arg Gly Ala Thr Ile Lys Pro Ser Val Leu Gln Val Glu
    175                 180                 185
 
cat cat cca tat ttg caa caa cct aga tta att gaa ttt gct caa tct   626
His His Pro Tyr Leu Gln Gln Pro Arg Leu Ile Glu Phe Ala Gln Ser
190                 195                 200                 205
 
aga gga att gct gtt act gct tat tct tct ttt gga cca caa tct ttt   674
Arg Gly Ile Ala Val Thr Ala Tyr Ser Ser Phe Gly Pro Gln Ser Phe
                210                 215                 220
 
gta gaa tta aat caa ggt aga gct tta aat act tca cca ttg ttt gaa   722
Val Glu Leu Asn Gln Gly Arg Ala Leu Asn Thr Ser Pro Leu Phe Glu
            225                 230                 235
 
aat gaa act att aag gct att gct gct aaa cac ggt aaa tca cca gca   770
Asn Glu Thr Ile Lys Ala Ile Ala Ala Lys His Gly Lys Ser Pro Ala
        240                 245                 250
 
cag gta tta tta aga tgg tca tca caa aga gga atc gct att att cca   818
Gln Val Leu Leu Arg Trp Ser Ser Gln Arg Gly Ile Ala Ile Ile Pro
    255                 260                 265
 
aaa tct aat act gtt cct cgt ttg ttg gaa aat aaa gat gtt aat tct   866
Lys Ser Asn Thr Val Pro Arg Leu Leu Glu Asn Lys Asp Val Asn Ser
270                 275                 280                 285
 
ttt gat ttg gat gaa caa gat ttt gct gat ata gct aaa ttg gac att   914
Phe Asp Leu Asp Glu Gln Asp Phe Ala Asp Ile Ala Lys Leu Asp Ile
                290                 295                 300
 
aat ttg aga ttt aat gat cct tgg gat tgg gat aaa att cca att ttt   962
Asn Leu Arg Phe Asn Asp Pro Trp Asp Trp Asp Lys Ile Pro Ile Phe
            305                 310                 315
 
gta gaattccgat g                                                  976
Val

 

<210> 12
<211> 318
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in E. coli

<400> 12
Met Pro Ser Ile Lys Leu Asn Ser Gly Tyr Asp Met Pro Ala Val Gly
 1               5                  10                  15      
Phe Gly Cys Trp Lys Val Asp Val Asp Thr Cys Ser Glu Gln Ile Tyr
            20                  25                  30          
Arg Ala Ile Lys Thr Gly Tyr Arg Leu Phe Asp Gly Ala Glu Asp Tyr
        35                  40                  45              
Ala Asn Glu Lys Leu Val Gly Ala Gly Val Lys Lys Ala Ile Asp Glu
    50                  55                  60                  
Gly Ile Val Lys Arg Glu Asp Leu Phe Leu Thr Ser Lys Leu Trp Asn
65                  70                  75                  80  
Asn Tyr His His Pro Asp Asn Val Glu Lys Ala Leu Asn Arg Thr Leu
                85                  90                  95      
Ser Asp Leu Gln Val Asp Tyr Val Asp Leu Phe Leu Ile His Phe Pro
            100                 105                 110         
Val Thr Phe Lys Phe Val Pro Leu Glu Glu Lys Tyr Pro Pro Gly Phe
        115                 120                 125             
Tyr Cys Gly Lys Gly Asp Asn Phe Asp Tyr Glu Asp Val Pro Ile Leu
    130                 135                 140                 
Glu Thr Trp Lys Ala Leu Glu Lys Leu Val Lys Ala Gly Lys Ile Arg
145                 150                 155                 160 
Ser Ile Gly Val Ser Asn Phe Pro Gly Ala Leu Leu Leu Asp Leu Leu
                165                 170                 175     
Arg Gly Ala Thr Ile Lys Pro Ser Val Leu Gln Val Glu His His Pro
            180                 185                 190         
Tyr Leu Gln Gln Pro Arg Leu Ile Glu Phe Ala Gln Ser Arg Gly Ile
        195                 200                 205             
Ala Val Thr Ala Tyr Ser Ser Phe Gly Pro Gln Ser Phe Val Glu Leu
    210                 215                 220                 
Asn Gln Gly Arg Ala Leu Asn Thr Ser Pro Leu Phe Glu Asn Glu Thr
225                 230                 235                 240 
Ile Lys Ala Ile Ala Ala Lys His Gly Lys Ser Pro Ala Gln Val Leu
                245                 250                 255     
Leu Arg Trp Ser Ser Gln Arg Gly Ile Ala Ile Ile Pro Lys Ser Asn
            260                 265                 270         
Thr Val Pro Arg Leu Leu Glu Asn Lys Asp Val Asn Ser Phe Asp Leu
        275                 280                 285             
Asp Glu Gln Asp Phe Ala Asp Ile Ala Lys Leu Asp Ile Asn Leu Arg
    290                 295                 300                 
Phe Asn Asp Pro Trp Asp Trp Asp Lys Ile Pro Ile Phe Val
305                 310                 315             


<210> 13
<211> 982
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in E. coli

<220> 
<221> CDS            
<222> (15)...(968)

<400> 13
gaatactcca tatg atg cca tct att aaa tta aat tca ggt tat gat atg   50
                Met Pro Ser Ile Lys Leu Asn Ser Gly Tyr Asp Met
                 1               5                   10
 
cca gct gtt ggt ttt gga tgt tgg aaa gta gat gtt gat act tgt tct   98
Pro Ala Val Gly Phe Gly Cys Trp Lys Val Asp Val Asp Thr Cys Ser
         15                  20                  25
 
gaa caa att tat aga gct att aaa act ggt tat aga ttg ttt gat ggt   146
Glu Gln Ile Tyr Arg Ala Ile Lys Thr Gly Tyr Arg Leu Phe Asp Gly
     30                  35                  40
 
gct gaa gat tat gct aat gaa aaa ttg gta gga gct ggt gtt aaa aag   194
Ala Glu Asp Tyr Ala Asn Glu Lys Leu Val Gly Ala Gly Val Lys Lys
 45                  50                  55                  60
 
gct att gat gaa gga att gtt aaa aga gaa gat ttg ttt ttg act tct   242
Ala Ile Asp Glu Gly Ile Val Lys Arg Glu Asp Leu Phe Leu Thr Ser
                 65                  70                  75
 
aaa ttg tgg aat aat tat cat cat cca gat aat gtt gaa aaa gct cta   290
Lys Leu Trp Asn Asn Tyr His His Pro Asp Asn Val Glu Lys Ala Leu
             80                  85                  90
 
aat aga act cta tct gat ttg caa gta gat tat gtt gac ttg ttt ttg   338
Asn Arg Thr Leu Ser Asp Leu Gln Val Asp Tyr Val Asp Leu Phe Leu
         95                 100                 105
 
att cat ttt cca gtt act ttt aaa ttc gtt cca ttg gaa gaa aaa tat   386
Ile His Phe Pro Val Thr Phe Lys Phe Val Pro Leu Glu Glu Lys Tyr
    110                 115                 120
 
cct cct ggt ttt tat tgt ggt aaa ggt gat aat ttt gat tat gaa gat   434
Pro Pro Gly Phe Tyr Cys Gly Lys Gly Asp Asn Phe Asp Tyr Glu Asp
125                 130                 135                 140
 
gtt cct ata ttg gaa act tgg aaa gct cta gaa aaa ttg gtt aaa gct   482
Val Pro Ile Leu Glu Thr Trp Lys Ala Leu Glu Lys Leu Val Lys Ala
                145                 150                 155
 
ggt aaa att aga tct att ggt gtt tca aat ttt cca ggt gct ttg ttg   530
Gly Lys Ile Arg Ser Ile Gly Val Ser Asn Phe Pro Gly Ala Leu Leu
            160                 165                 170
 
ttg gat ttg ttg aga ggt gct aca att aaa cca tct gtt ttg caa gtt   578
Leu Asp Leu Leu Arg Gly Ala Thr Ile Lys Pro Ser Val Leu Gln Val
        175                 180                 185
 
gaa cat cat cca tat ttg caa caa cct aga tta att gaa ttt gct caa   626
Glu His His Pro Tyr Leu Gln Gln Pro Arg Leu Ile Glu Phe Ala Gln
    190                 195                 200
 
tct aga gga att gct gtt act gct tat tct tct ttt gga cca caa tct   674
Ser Arg Gly Ile Ala Val Thr Ala Tyr Ser Ser Phe Gly Pro Gln Ser
205                 210                 215                 220
 
ttt gta gaa tta aat caa ggt aga gct tta aat act tca cca ttg ttt   722
Phe Val Glu Leu Asn Gln Gly Arg Ala Leu Asn Thr Ser Pro Leu Phe
                225                 230                 235
 
gaa aat gaa act att aag gct att gct gct aaa cac ggt aaa tca cca   770
Glu Asn Glu Thr Ile Lys Ala Ile Ala Ala Lys His Gly Lys Ser Pro
            240                 245                 250
 
gca cag gta tta tta aga tgg tca tca caa aga gga atc gct att att   818
Ala Gln Val Leu Leu Arg Trp Ser Ser Gln Arg Gly Ile Ala Ile Ile
        255                 260                 265
 
cca aaa tct aat act gtt cct cgt ttg ttg gaa aat aaa gat gtt aat   866
Pro Lys Ser Asn Thr Val Pro Arg Leu Leu Glu Asn Lys Asp Val Asn
    270                 275                 280
 
tct ttt gat ttg gat gaa caa gat ttt gct gat ata gct aaa ttg gac   914
Ser Phe Asp Leu Asp Glu Gln Asp Phe Ala Asp Ile Ala Lys Leu Asp
285                 290                 295                 300
 
att aat ttg aga ttt aat gat cct tgg gat tgg gat aaa att cca att   962
Ile Asn Leu Arg Phe Asn Asp Pro Trp Asp Trp Asp Lys Ile Pro Ile
                305                 310                 315
 
ttt gta actagtcgat gcct                                           982
Phe Val

 

<210> 14
<211> 318
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in E. coli

<400> 14
Met Pro Ser Ile Lys Leu Asn Ser Gly Tyr Asp Met Pro Ala Val Gly
 1               5                  10                  15      
Phe Gly Cys Trp Lys Val Asp Val Asp Thr Cys Ser Glu Gln Ile Tyr
            20                  25                  30          
Arg Ala Ile Lys Thr Gly Tyr Arg Leu Phe Asp Gly Ala Glu Asp Tyr
        35                  40                  45              
Ala Asn Glu Lys Leu Val Gly Ala Gly Val Lys Lys Ala Ile Asp Glu
    50                  55                  60                  
Gly Ile Val Lys Arg Glu Asp Leu Phe Leu Thr Ser Lys Leu Trp Asn
65                  70                  75                  80  
Asn Tyr His His Pro Asp Asn Val Glu Lys Ala Leu Asn Arg Thr Leu
                85                  90                  95      
Ser Asp Leu Gln Val Asp Tyr Val Asp Leu Phe Leu Ile His Phe Pro
            100                 105                 110         
Val Thr Phe Lys Phe Val Pro Leu Glu Glu Lys Tyr Pro Pro Gly Phe
        115                 120                 125             
Tyr Cys Gly Lys Gly Asp Asn Phe Asp Tyr Glu Asp Val Pro Ile Leu
    130                 135                 140                 
Glu Thr Trp Lys Ala Leu Glu Lys Leu Val Lys Ala Gly Lys Ile Arg
145                 150                 155                 160 
Ser Ile Gly Val Ser Asn Phe Pro Gly Ala Leu Leu Leu Asp Leu Leu
                165                 170                 175     
Arg Gly Ala Thr Ile Lys Pro Ser Val Leu Gln Val Glu His His Pro
            180                 185                 190         
Tyr Leu Gln Gln Pro Arg Leu Ile Glu Phe Ala Gln Ser Arg Gly Ile
        195                 200                 205             
Ala Val Thr Ala Tyr Ser Ser Phe Gly Pro Gln Ser Phe Val Glu Leu
    210                 215                 220                 
Asn Gln Gly Arg Ala Leu Asn Thr Ser Pro Leu Phe Glu Asn Glu Thr
225                 230                 235                 240 
Ile Lys Ala Ile Ala Ala Lys His Gly Lys Ser Pro Ala Gln Val Leu
                245                 250                 255     
Leu Arg Trp Ser Ser Gln Arg Gly Ile Ala Ile Ile Pro Lys Ser Asn
            260                 265                 270         
Thr Val Pro Arg Leu Leu Glu Asn Lys Asp Val Asn Ser Phe Asp Leu
        275                 280                 285             
Asp Glu Gln Asp Phe Ala Asp Ile Ala Lys Leu Asp Ile Asn Leu Arg
    290                 295                 300                 
Phe Asn Asp Pro Trp Asp Trp Asp Lys Ile Pro Ile Phe Val
305                 310                 315             


<210> 15
<211> 954
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in P. pastoris

<220> 
<221> CDS            
<222> (1)...(954)

<400> 15
atg cca tct att aaa tta aat tca gga tat gat atg cca gct gtt gga   48
Met Pro Ser Ile Lys Leu Asn Ser Gly Tyr Asp Met Pro Ala Val Gly
 1               5                   10                  15
 
ttt ggt tgt tgg aaa gtt gat gtt gat act tgt tct gaa caa att tat   96
Phe Gly Cys Trp Lys Val Asp Val Asp Thr Cys Ser Glu Gln Ile Tyr
             20                  25                  30
 
aga gct att aaa act gga tat aga ttg ttt gat gga gct gaa gat tat   144
Arg Ala Ile Lys Thr Gly Tyr Arg Leu Phe Asp Gly Ala Glu Asp Tyr
         35                  40                  45
 
gct aat gaa aaa tta gtt gga gca gga gtt aaa aag gct att gat gaa   192
Ala Asn Glu Lys Leu Val Gly Ala Gly Val Lys Lys Ala Ile Asp Glu
     50                  55                  60
 
gga att gtt aaa aga gaa gat ttg ttt ttg act tct aag ttg tgg aat   240
Gly Ile Val Lys Arg Glu Asp Leu Phe Leu Thr Ser Lys Leu Trp Asn
 65                  70                  75                  80
 
aat tat cat cat cca gat aat gtt gaa aaa gct ctt aat aga act tta   288
Asn Tyr His His Pro Asp Asn Val Glu Lys Ala Leu Asn Arg Thr Leu
                 85                  90                  95
 
tct gat ttg caa gtt gat tat gtt gac ttg ttt ttg att cat ttt cca   336
Ser Asp Leu Gln Val Asp Tyr Val Asp Leu Phe Leu Ile His Phe Pro
            100                 105                 110
 
gtt act ttt aaa ttt gtt cca tta gaa gaa aaa tac cct cct gga ttt   384
Val Thr Phe Lys Phe Val Pro Leu Glu Glu Lys Tyr Pro Pro Gly Phe
        115                 120                 125
 
tat tgt gga aaa gga gat aat ttt gat tat gaa gat gtg cca att ctt   432
Tyr Cys Gly Lys Gly Asp Asn Phe Asp Tyr Glu Asp Val Pro Ile Leu
    130                 135                 140
 
gaa aca tgg aaa gct ctt gaa aaa ttg gtt aaa gct gga aaa att agg   480
Glu Thr Trp Lys Ala Leu Glu Lys Leu Val Lys Ala Gly Lys Ile Arg
145                 150                 155                 160
 
tct att gga gtt tct aat ttt cct ggc gct ttg ttg ttg gat ttg ttg   528
Ser Ile Gly Val Ser Asn Phe Pro Gly Ala Leu Leu Leu Asp Leu Leu
                165                 170                 175
 
aga gga gct act att aaa cct tct gtt ttg caa gtg gaa cat cat cca   576
Arg Gly Ala Thr Ile Lys Pro Ser Val Leu Gln Val Glu His His Pro
            180                 185                 190
 
tat ttg caa caa ccc aga ttg att gaa ttt gca caa tct aga gga atc   624
Tyr Leu Gln Gln Pro Arg Leu Ile Glu Phe Ala Gln Ser Arg Gly Ile
        195                 200                 205
 
gct gtt act gct tat tct tct ttt ggt cca caa tct ttt gtt gaa tta   672
Ala Val Thr Ala Tyr Ser Ser Phe Gly Pro Gln Ser Phe Val Glu Leu
    210                 215                 220
 
aat caa ggt aga gct tta aat act tct cca ttg ttt gag aat gaa act   720
Asn Gln Gly Arg Ala Leu Asn Thr Ser Pro Leu Phe Glu Asn Glu Thr
225                 230                 235                 240
 
att aag gct att gct gct aaa cat gga aaa tca cct gct caa gtt ttg   768
Ile Lys Ala Ile Ala Ala Lys His Gly Lys Ser Pro Ala Gln Val Leu
                245                 250                 255
 
ttg cgt tgg tct tct caa aga gga att gct att att cca aaa tct aat   816
Leu Arg Trp Ser Ser Gln Arg Gly Ile Ala Ile Ile Pro Lys Ser Asn
            260                 265                 270
 
act gtt cct aga ttg tta gaa aat aaa gat gtt aat tct ttt gat ttg   864
Thr Val Pro Arg Leu Leu Glu Asn Lys Asp Val Asn Ser Phe Asp Leu
        275                 280                 285
 
gat gaa caa gac ttt gca gat ata gct aaa ttg gac att aat ttg aga   912
Asp Glu Gln Asp Phe Ala Asp Ile Ala Lys Leu Asp Ile Asn Leu Arg
    290                 295                 300
 
ttt aat gat cct tgg gat tgg gat aaa att cct att ttt gtt           954
Phe Asn Asp Pro Trp Asp Trp Asp Lys Ile Pro Ile Phe Val
305                 310                 315
 


<210> 16
<211> 318
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in P. pastoris

<400> 16
Met Pro Ser Ile Lys Leu Asn Ser Gly Tyr Asp Met Pro Ala Val Gly
 1               5                  10                  15      
Phe Gly Cys Trp Lys Val Asp Val Asp Thr Cys Ser Glu Gln Ile Tyr
            20                  25                  30          
Arg Ala Ile Lys Thr Gly Tyr Arg Leu Phe Asp Gly Ala Glu Asp Tyr
        35                  40                  45              
Ala Asn Glu Lys Leu Val Gly Ala Gly Val Lys Lys Ala Ile Asp Glu
    50                  55                  60                  
Gly Ile Val Lys Arg Glu Asp Leu Phe Leu Thr Ser Lys Leu Trp Asn
65                  70                  75                  80  
Asn Tyr His His Pro Asp Asn Val Glu Lys Ala Leu Asn Arg Thr Leu
                85                  90                  95      
Ser Asp Leu Gln Val Asp Tyr Val Asp Leu Phe Leu Ile His Phe Pro
            100                 105                 110         
Val Thr Phe Lys Phe Val Pro Leu Glu Glu Lys Tyr Pro Pro Gly Phe
        115                 120                 125             
Tyr Cys Gly Lys Gly Asp Asn Phe Asp Tyr Glu Asp Val Pro Ile Leu
    130                 135                 140                 
Glu Thr Trp Lys Ala Leu Glu Lys Leu Val Lys Ala Gly Lys Ile Arg
145                 150                 155                 160 
Ser Ile Gly Val Ser Asn Phe Pro Gly Ala Leu Leu Leu Asp Leu Leu
                165                 170                 175     
Arg Gly Ala Thr Ile Lys Pro Ser Val Leu Gln Val Glu His His Pro
            180                 185                 190         
Tyr Leu Gln Gln Pro Arg Leu Ile Glu Phe Ala Gln Ser Arg Gly Ile
        195                 200                 205             
Ala Val Thr Ala Tyr Ser Ser Phe Gly Pro Gln Ser Phe Val Glu Leu
    210                 215                 220                 
Asn Gln Gly Arg Ala Leu Asn Thr Ser Pro Leu Phe Glu Asn Glu Thr
225                 230                 235                 240 
Ile Lys Ala Ile Ala Ala Lys His Gly Lys Ser Pro Ala Gln Val Leu
                245                 250                 255     
Leu Arg Trp Ser Ser Gln Arg Gly Ile Ala Ile Ile Pro Lys Ser Asn
            260                 265                 270         
Thr Val Pro Arg Leu Leu Glu Asn Lys Asp Val Asn Ser Phe Asp Leu
        275                 280                 285             
Asp Glu Gln Asp Phe Ala Asp Ile Ala Lys Leu Asp Ile Asn Leu Arg
    290                 295                 300                 
Phe Asn Asp Pro Trp Asp Trp Asp Lys Ile Pro Ile Phe Val
305                 310                 315             


<210> 17
<211> 976
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in P. pastoris

<220> 
<221> CDS            
<222> (12)...(965)

<400> 17
tactcaagct t atg cca tct att aaa tta aat tca gga tat gat atg cca  50
             Met Pro Ser Ile Lys Leu Asn Ser Gly Tyr Asp Met Pro
              1               5                   10
 
gct gtt gga ttt ggt tgt tgg aaa gtt gat gtt gat act tgt tct gaa   98
Ala Val Gly Phe Gly Cys Trp Lys Val Asp Val Asp Thr Cys Ser Glu
     15                  20                  25
 
caa att tat aga gct att aaa act gga tat aga ttg ttt gat gga gct   146
Gln Ile Tyr Arg Ala Ile Lys Thr Gly Tyr Arg Leu Phe Asp Gly Ala
 30                  35                  40                  45
 
gaa gat tat gct aat gaa aaa tta gtt gga gca gga gtt aaa aag gct   194
Glu Asp Tyr Ala Asn Glu Lys Leu Val Gly Ala Gly Val Lys Lys Ala
                 50                  55                  60
 
att gat gaa gga att gtt aaa aga gaa gat ttg ttt ttg act tct aag   242
Ile Asp Glu Gly Ile Val Lys Arg Glu Asp Leu Phe Leu Thr Ser Lys
             65                  70                  75
 
ttg tgg aat aat tat cat cat cca gat aat gtt gaa aaa gct ctt aat   290
Leu Trp Asn Asn Tyr His His Pro Asp Asn Val Glu Lys Ala Leu Asn
         80                  85                  90
 
aga act tta tct gat ttg caa gtt gat tat gtt gac ttg ttt ttg att   338
Arg Thr Leu Ser Asp Leu Gln Val Asp Tyr Val Asp Leu Phe Leu Ile
     95                 100                 105
 
cat ttt cca gtt act ttt aaa ttt gtt cca tta gaa gaa aaa tac cct   386
His Phe Pro Val Thr Phe Lys Phe Val Pro Leu Glu Glu Lys Tyr Pro
110                 115                 120                 125
 
cct gga ttt tat tgt gga aaa gga gat aat ttt gat tat gaa gat gtg   434
Pro Gly Phe Tyr Cys Gly Lys Gly Asp Asn Phe Asp Tyr Glu Asp Val
                130                 135                 140
 
cca att ctt gaa aca tgg aaa gct ctt gaa aaa ttg gtt aaa gct gga   482
Pro Ile Leu Glu Thr Trp Lys Ala Leu Glu Lys Leu Val Lys Ala Gly
            145                 150                 155
 
aaa att agg tct att gga gtt tct aat ttt cct ggc gct ttg ttg ttg   530
Lys Ile Arg Ser Ile Gly Val Ser Asn Phe Pro Gly Ala Leu Leu Leu
        160                 165                 170
 
gat ttg ttg aga gga gct act att aaa cct tct gtt ttg caa gtg gaa   578
Asp Leu Leu Arg Gly Ala Thr Ile Lys Pro Ser Val Leu Gln Val Glu
    175                 180                 185
 
cat cat cca tat ttg caa caa ccc aga ttg att gaa ttt gca caa tct   626
His His Pro Tyr Leu Gln Gln Pro Arg Leu Ile Glu Phe Ala Gln Ser
190                 195                 200                 205
 
aga gga atc gct gtt act gct tat tct tct ttt ggt cca caa tct ttt   674
Arg Gly Ile Ala Val Thr Ala Tyr Ser Ser Phe Gly Pro Gln Ser Phe
                210                 215                 220
 
gtt gaa tta aat caa ggt aga gct tta aat act tct cca ttg ttt gag   722
Val Glu Leu Asn Gln Gly Arg Ala Leu Asn Thr Ser Pro Leu Phe Glu
            225                 230                 235
 
aat gaa act att aag gct att gct gct aaa cat gga aaa tca cct gct   770
Asn Glu Thr Ile Lys Ala Ile Ala Ala Lys His Gly Lys Ser Pro Ala
        240                 245                 250
 
caa gtt ttg ttg cgt tgg tct tct caa aga gga att gct att att cca   818
Gln Val Leu Leu Arg Trp Ser Ser Gln Arg Gly Ile Ala Ile Ile Pro
    255                 260                 265
 
aaa tct aat act gtt cct aga ttg tta gaa aat aaa gat gtt aat tct   866
Lys Ser Asn Thr Val Pro Arg Leu Leu Glu Asn Lys Asp Val Asn Ser
270                 275                 280                 285
 
ttt gat ttg gat gaa caa gac ttt gca gat ata gct aaa ttg gac att   914
Phe Asp Leu Asp Glu Gln Asp Phe Ala Asp Ile Ala Lys Leu Asp Ile
                290                 295                 300
 
aat ttg aga ttt aat gat cct tgg gat tgg gat aaa att cct att ttt   962
Asn Leu Arg Phe Asn Asp Pro Trp Asp Trp Asp Lys Ile Pro Ile Phe
            305                 310                 315
 
gtt gaattccgat g                                                  976
Val

 

<210> 18
<211> 318
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in P. pastoris

<400> 18
Met Pro Ser Ile Lys Leu Asn Ser Gly Tyr Asp Met Pro Ala Val Gly
 1               5                  10                  15      
Phe Gly Cys Trp Lys Val Asp Val Asp Thr Cys Ser Glu Gln Ile Tyr
            20                  25                  30          
Arg Ala Ile Lys Thr Gly Tyr Arg Leu Phe Asp Gly Ala Glu Asp Tyr
        35                  40                  45              
Ala Asn Glu Lys Leu Val Gly Ala Gly Val Lys Lys Ala Ile Asp Glu
    50                  55                  60                  
Gly Ile Val Lys Arg Glu Asp Leu Phe Leu Thr Ser Lys Leu Trp Asn
65                  70                  75                  80  
Asn Tyr His His Pro Asp Asn Val Glu Lys Ala Leu Asn Arg Thr Leu
                85                  90                  95      
Ser Asp Leu Gln Val Asp Tyr Val Asp Leu Phe Leu Ile His Phe Pro
            100                 105                 110         
Val Thr Phe Lys Phe Val Pro Leu Glu Glu Lys Tyr Pro Pro Gly Phe
        115                 120                 125             
Tyr Cys Gly Lys Gly Asp Asn Phe Asp Tyr Glu Asp Val Pro Ile Leu
    130                 135                 140                 
Glu Thr Trp Lys Ala Leu Glu Lys Leu Val Lys Ala Gly Lys Ile Arg
145                 150                 155                 160 
Ser Ile Gly Val Ser Asn Phe Pro Gly Ala Leu Leu Leu Asp Leu Leu
                165                 170                 175     
Arg Gly Ala Thr Ile Lys Pro Ser Val Leu Gln Val Glu His His Pro
            180                 185                 190         
Tyr Leu Gln Gln Pro Arg Leu Ile Glu Phe Ala Gln Ser Arg Gly Ile
        195                 200                 205             
Ala Val Thr Ala Tyr Ser Ser Phe Gly Pro Gln Ser Phe Val Glu Leu
    210                 215                 220                 
Asn Gln Gly Arg Ala Leu Asn Thr Ser Pro Leu Phe Glu Asn Glu Thr
225                 230                 235                 240 
Ile Lys Ala Ile Ala Ala Lys His Gly Lys Ser Pro Ala Gln Val Leu
                245                 250                 255     
Leu Arg Trp Ser Ser Gln Arg Gly Ile Ala Ile Ile Pro Lys Ser Asn
            260                 265                 270         
Thr Val Pro Arg Leu Leu Glu Asn Lys Asp Val Asn Ser Phe Asp Leu
        275                 280                 285             
Asp Glu Gln Asp Phe Ala Asp Ile Ala Lys Leu Asp Ile Asn Leu Arg
    290                 295                 300                 
Phe Asn Asp Pro Trp Asp Trp Asp Lys Ile Pro Ile Phe Val
305                 310                 315             


<210> 19
<211> 982
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in P. pastoris

<220> 
<221> CDS            
<222> (15)...(968)

<400> 19
gaatactcca tatg atg cca tct att aaa tta aat tca gga tat gat atg   50
                Met Pro Ser Ile Lys Leu Asn Ser Gly Tyr Asp Met
                 1               5                   10
 
cca gct gtt gga ttt ggt tgt tgg aaa gtt gat gtt gat act tgt tct   98
Pro Ala Val Gly Phe Gly Cys Trp Lys Val Asp Val Asp Thr Cys Ser
         15                  20                  25
 
gaa caa att tat aga gct att aaa act gga tat aga ttg ttt gat gga   146
Glu Gln Ile Tyr Arg Ala Ile Lys Thr Gly Tyr Arg Leu Phe Asp Gly
     30                  35                  40
 
gct gaa gat tat gct aat gaa aaa tta gtt gga gca gga gtt aaa aag   194
Ala Glu Asp Tyr Ala Asn Glu Lys Leu Val Gly Ala Gly Val Lys Lys
 45                  50                  55                  60
 
gct att gat gaa gga att gtt aaa aga gaa gat ttg ttt ttg act tct   242
Ala Ile Asp Glu Gly Ile Val Lys Arg Glu Asp Leu Phe Leu Thr Ser
                 65                  70                  75
 
aag ttg tgg aat aat tat cat cat cca gat aat gtt gaa aaa gct ctt   290
Lys Leu Trp Asn Asn Tyr His His Pro Asp Asn Val Glu Lys Ala Leu
             80                  85                  90
 
aat aga act tta tct gat ttg caa gtt gat tat gtt gac ttg ttt ttg   338
Asn Arg Thr Leu Ser Asp Leu Gln Val Asp Tyr Val Asp Leu Phe Leu
         95                 100                 105
 
att cat ttt cca gtt act ttt aaa ttt gtt cca tta gaa gaa aaa tac   386
Ile His Phe Pro Val Thr Phe Lys Phe Val Pro Leu Glu Glu Lys Tyr
    110                 115                 120
 
cct cct gga ttt tat tgt gga aaa gga gat aat ttt gat tat gaa gat   434
Pro Pro Gly Phe Tyr Cys Gly Lys Gly Asp Asn Phe Asp Tyr Glu Asp
125                 130                 135                 140
 
gtg cca att ctt gaa aca tgg aaa gct ctt gaa aaa ttg gtt aaa gct   482
Val Pro Ile Leu Glu Thr Trp Lys Ala Leu Glu Lys Leu Val Lys Ala
                145                 150                 155
 
gga aaa att agg tct att gga gtt tct aat ttt cct ggc gct ttg ttg   530
Gly Lys Ile Arg Ser Ile Gly Val Ser Asn Phe Pro Gly Ala Leu Leu
            160                 165                 170
 
ttg gat ttg ttg aga gga gct act att aaa cct tct gtt ttg caa gtg   578
Leu Asp Leu Leu Arg Gly Ala Thr Ile Lys Pro Ser Val Leu Gln Val
        175                 180                 185
 
gaa cat cat cca tat ttg caa caa ccc aga ttg att gaa ttt gca caa   626
Glu His His Pro Tyr Leu Gln Gln Pro Arg Leu Ile Glu Phe Ala Gln
    190                 195                 200
 
tct aga gga atc gct gtt act gct tat tct tct ttt ggt cca caa tct   674
Ser Arg Gly Ile Ala Val Thr Ala Tyr Ser Ser Phe Gly Pro Gln Ser
205                 210                 215                 220
 
ttt gtt gaa tta aat caa ggt aga gct tta aat act tct cca ttg ttt   722
Phe Val Glu Leu Asn Gln Gly Arg Ala Leu Asn Thr Ser Pro Leu Phe
                225                 230                 235
 
gag aat gaa act att aag gct att gct gct aaa cat gga aaa tca cct   770
Glu Asn Glu Thr Ile Lys Ala Ile Ala Ala Lys His Gly Lys Ser Pro
            240                 245                 250
 
gct caa gtt ttg ttg cgt tgg tct tct caa aga gga att gct att att   818
Ala Gln Val Leu Leu Arg Trp Ser Ser Gln Arg Gly Ile Ala Ile Ile
        255                 260                 265
 
cca aaa tct aat act gtt cct aga ttg tta gaa aat aaa gat gtt aat   866
Pro Lys Ser Asn Thr Val Pro Arg Leu Leu Glu Asn Lys Asp Val Asn
    270                 275                 280
 
tct ttt gat ttg gat gaa caa gac ttt gca gat ata gct aaa ttg gac   914
Ser Phe Asp Leu Asp Glu Gln Asp Phe Ala Asp Ile Ala Lys Leu Asp
285                 290                 295                 300
 
att aat ttg aga ttt aat gat cct tgg gat tgg gat aaa att cct att   962
Ile Asn Leu Arg Phe Asn Asp Pro Trp Asp Trp Asp Lys Ile Pro Ile
                305                 310                 315
 
ttt gtt actagtcgat gcct                                           982
Phe Val

 

<210> 20
<211> 318
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in P. pastoris

<400> 20
Met Pro Ser Ile Lys Leu Asn Ser Gly Tyr Asp Met Pro Ala Val Gly
 1               5                  10                  15      
Phe Gly Cys Trp Lys Val Asp Val Asp Thr Cys Ser Glu Gln Ile Tyr
            20                  25                  30          
Arg Ala Ile Lys Thr Gly Tyr Arg Leu Phe Asp Gly Ala Glu Asp Tyr
        35                  40                  45              
Ala Asn Glu Lys Leu Val Gly Ala Gly Val Lys Lys Ala Ile Asp Glu
    50                  55                  60                  
Gly Ile Val Lys Arg Glu Asp Leu Phe Leu Thr Ser Lys Leu Trp Asn
65                  70                  75                  80  
Asn Tyr His His Pro Asp Asn Val Glu Lys Ala Leu Asn Arg Thr Leu
                85                  90                  95      
Ser Asp Leu Gln Val Asp Tyr Val Asp Leu Phe Leu Ile His Phe Pro
            100                 105                 110         
Val Thr Phe Lys Phe Val Pro Leu Glu Glu Lys Tyr Pro Pro Gly Phe
        115                 120                 125             
Tyr Cys Gly Lys Gly Asp Asn Phe Asp Tyr Glu Asp Val Pro Ile Leu
    130                 135                 140                 
Glu Thr Trp Lys Ala Leu Glu Lys Leu Val Lys Ala Gly Lys Ile Arg
145                 150                 155                 160 
Ser Ile Gly Val Ser Asn Phe Pro Gly Ala Leu Leu Leu Asp Leu Leu
                165                 170                 175     
Arg Gly Ala Thr Ile Lys Pro Ser Val Leu Gln Val Glu His His Pro
            180                 185                 190         
Tyr Leu Gln Gln Pro Arg Leu Ile Glu Phe Ala Gln Ser Arg Gly Ile
        195                 200                 205             
Ala Val Thr Ala Tyr Ser Ser Phe Gly Pro Gln Ser Phe Val Glu Leu
    210                 215                 220                 
Asn Gln Gly Arg Ala Leu Asn Thr Ser Pro Leu Phe Glu Asn Glu Thr
225                 230                 235                 240 
Ile Lys Ala Ile Ala Ala Lys His Gly Lys Ser Pro Ala Gln Val Leu
                245                 250                 255     
Leu Arg Trp Ser Ser Gln Arg Gly Ile Ala Ile Ile Pro Lys Ser Asn
            260                 265                 270         
Thr Val Pro Arg Leu Leu Glu Asn Lys Asp Val Asn Ser Phe Asp Leu
        275                 280                 285             
Asp Glu Gln Asp Phe Ala Asp Ile Ala Lys Leu Asp Ile Asn Leu Arg
    290                 295                 300                 
Phe Asn Asp Pro Trp Asp Trp Asp Lys Ile Pro Ile Phe Val
305                 310                 315             


<210> 21
<211> 954
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in K. lactis

<220> 
<221> CDS            
<222> (1)...(954)

<400> 21
atg cca tct att aaa tta aac tct ggt tat gat atg cca gct gtt ggt   48
Met Pro Ser Ile Lys Leu Asn Ser Gly Tyr Asp Met Pro Ala Val Gly
 1               5                   10                  15
 
ttc ggt tgt tgg aaa gtt gat gtt gat act tgt tct gaa caa att tat   96
Phe Gly Cys Trp Lys Val Asp Val Asp Thr Cys Ser Glu Gln Ile Tyr
             20                  25                  30
 
aga gct att aaa act ggt tat aga ttg ttc gat ggt gct gaa gat tat   144
Arg Ala Ile Lys Thr Gly Tyr Arg Leu Phe Asp Gly Ala Glu Asp Tyr
         35                  40                  45
 
gct aat gaa aaa ttg gtg gga gcc ggt gtt aaa aag gct att gat gaa   192
Ala Asn Glu Lys Leu Val Gly Ala Gly Val Lys Lys Ala Ile Asp Glu
     50                  55                  60
 
gga att gtt aaa aga gaa gat ttg ttc cta act tct aaa ttg tgg aat   240
Gly Ile Val Lys Arg Glu Asp Leu Phe Leu Thr Ser Lys Leu Trp Asn
 65                  70                  75                  80
 
aat tat cat cat cca gat aat gtt gaa aag gca tta aat aga act tta   288
Asn Tyr His His Pro Asp Asn Val Glu Lys Ala Leu Asn Arg Thr Leu
                 85                  90                  95
 
tct gat tta cag gtg gat tat gtt gat ttg ttc tta att cat ttt cca   336
Ser Asp Leu Gln Val Asp Tyr Val Asp Leu Phe Leu Ile His Phe Pro
            100                 105                 110
 
gtt act ttc aaa ttc gtt cca ttg gaa gaa aaa tat cca cca ggt ttc   384
Val Thr Phe Lys Phe Val Pro Leu Glu Glu Lys Tyr Pro Pro Gly Phe
        115                 120                 125
 
tat tgt ggt aag ggt gat aat ttc gat tat gaa gat gtt cca att ttg   432
Tyr Cys Gly Lys Gly Asp Asn Phe Asp Tyr Glu Asp Val Pro Ile Leu
    130                 135                 140
 
gaa act tgg aag gct ttg gaa aaa ctt gtt aaa gcg gga aag att aga   480
Glu Thr Trp Lys Ala Leu Glu Lys Leu Val Lys Ala Gly Lys Ile Arg
145                 150                 155                 160
 
tct att ggt gtt tct aat ttt cca ggt gct cta ttg cta gat ttg ttg   528
Ser Ile Gly Val Ser Asn Phe Pro Gly Ala Leu Leu Leu Asp Leu Leu
                165                 170                 175
 
aga ggt gct act att aaa cca tct gtt cta caa gta gag cat cat cca   576
Arg Gly Ala Thr Ile Lys Pro Ser Val Leu Gln Val Glu His His Pro
            180                 185                 190
 
tat tta cag caa cca agg ttg att gag ttc gct caa tcg aga gga att   624
Tyr Leu Gln Gln Pro Arg Leu Ile Glu Phe Ala Gln Ser Arg Gly Ile
        195                 200                 205
 
gct gtt act gct tat tct tct ttc ggt cca caa tct ttc gtt gaa tta   672
Ala Val Thr Ala Tyr Ser Ser Phe Gly Pro Gln Ser Phe Val Glu Leu
    210                 215                 220
 
aat caa ggt aga gct tta aat act tca cca ttg ttc gaa aat gaa act   720
Asn Gln Gly Arg Ala Leu Asn Thr Ser Pro Leu Phe Glu Asn Glu Thr
225                 230                 235                 240
 
att aaa gct att gct gct aaa cat ggt aag tct cct gct caa gtt ttg   768
Ile Lys Ala Ile Ala Ala Lys His Gly Lys Ser Pro Ala Gln Val Leu
                245                 250                 255
 
ttg aga tgg tct tct caa aga gga ata gcc atc att cca aaa tct aat   816
Leu Arg Trp Ser Ser Gln Arg Gly Ile Ala Ile Ile Pro Lys Ser Asn
            260                 265                 270
 
act gtt cct aga ttg ttg gaa aat aaa gat gtt aat tct ttc gat ttg   864
Thr Val Pro Arg Leu Leu Glu Asn Lys Asp Val Asn Ser Phe Asp Leu
        275                 280                 285
 
gat gaa caa gat ttc gct gac att gct aaa ttg gat ata aac ttg aga   912
Asp Glu Gln Asp Phe Ala Asp Ile Ala Lys Leu Asp Ile Asn Leu Arg
    290                 295                 300
 
ttc aat gat cca tgg gat tgg gac aaa att cca att ttc gtg           954
Phe Asn Asp Pro Trp Asp Trp Asp Lys Ile Pro Ile Phe Val
305                 310                 315
 


<210> 22
<211> 318
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in K. lactis

<400> 22
Met Pro Ser Ile Lys Leu Asn Ser Gly Tyr Asp Met Pro Ala Val Gly
 1               5                  10                  15      
Phe Gly Cys Trp Lys Val Asp Val Asp Thr Cys Ser Glu Gln Ile Tyr
            20                  25                  30          
Arg Ala Ile Lys Thr Gly Tyr Arg Leu Phe Asp Gly Ala Glu Asp Tyr
        35                  40                  45              
Ala Asn Glu Lys Leu Val Gly Ala Gly Val Lys Lys Ala Ile Asp Glu
    50                  55                  60                  
Gly Ile Val Lys Arg Glu Asp Leu Phe Leu Thr Ser Lys Leu Trp Asn
65                  70                  75                  80  
Asn Tyr His His Pro Asp Asn Val Glu Lys Ala Leu Asn Arg Thr Leu
                85                  90                  95      
Ser Asp Leu Gln Val Asp Tyr Val Asp Leu Phe Leu Ile His Phe Pro
            100                 105                 110         
Val Thr Phe Lys Phe Val Pro Leu Glu Glu Lys Tyr Pro Pro Gly Phe
        115                 120                 125             
Tyr Cys Gly Lys Gly Asp Asn Phe Asp Tyr Glu Asp Val Pro Ile Leu
    130                 135                 140                 
Glu Thr Trp Lys Ala Leu Glu Lys Leu Val Lys Ala Gly Lys Ile Arg
145                 150                 155                 160 
Ser Ile Gly Val Ser Asn Phe Pro Gly Ala Leu Leu Leu Asp Leu Leu
                165                 170                 175     
Arg Gly Ala Thr Ile Lys Pro Ser Val Leu Gln Val Glu His His Pro
            180                 185                 190         
Tyr Leu Gln Gln Pro Arg Leu Ile Glu Phe Ala Gln Ser Arg Gly Ile
        195                 200                 205             
Ala Val Thr Ala Tyr Ser Ser Phe Gly Pro Gln Ser Phe Val Glu Leu
    210                 215                 220                 
Asn Gln Gly Arg Ala Leu Asn Thr Ser Pro Leu Phe Glu Asn Glu Thr
225                 230                 235                 240 
Ile Lys Ala Ile Ala Ala Lys His Gly Lys Ser Pro Ala Gln Val Leu
                245                 250                 255     
Leu Arg Trp Ser Ser Gln Arg Gly Ile Ala Ile Ile Pro Lys Ser Asn
            260                 265                 270         
Thr Val Pro Arg Leu Leu Glu Asn Lys Asp Val Asn Ser Phe Asp Leu
        275                 280                 285             
Asp Glu Gln Asp Phe Ala Asp Ile Ala Lys Leu Asp Ile Asn Leu Arg
    290                 295                 300                 
Phe Asn Asp Pro Trp Asp Trp Asp Lys Ile Pro Ile Phe Val
305                 310                 315             


<210> 23
<211> 954
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in Z. mobilis

<220> 
<221> CDS            
<222> (1)...(954)

<400> 23
atg ccg tct att aaa tta aat tct ggt tat gat atg cca gcc gtt ggt   48
Met Pro Ser Ile Lys Leu Asn Ser Gly Tyr Asp Met Pro Ala Val Gly
 1               5                   10                  15
 
ttt ggt tgt tgg aaa gtt gat gtt gat acc tgt tct gaa caa att tat   96
Phe Gly Cys Trp Lys Val Asp Val Asp Thr Cys Ser Glu Gln Ile Tyr
             20                  25                  30
 
cgt gcc att aag aca gga tat cgt ttg ttt gat ggt gcc gaa gat tat   144
Arg Ala Ile Lys Thr Gly Tyr Arg Leu Phe Asp Gly Ala Glu Asp Tyr
         35                  40                  45
 
gcc aac gaa aaa tta gtt ggt gct ggt gtt aag aaa gcc att gat gag   192
Ala Asn Glu Lys Leu Val Gly Ala Gly Val Lys Lys Ala Ile Asp Glu
     50                  55                  60
 
ggc att gtt aaa cgt gaa gat ttg ttt tta acc tct aaa ttg tgg aat   240
Gly Ile Val Lys Arg Glu Asp Leu Phe Leu Thr Ser Lys Leu Trp Asn
 65                  70                  75                  80
 
aat tat cat cat ccg gat aac gtt gaa aaa gcc ctt aat cgt acc ttg   288
Asn Tyr His His Pro Asp Asn Val Glu Lys Ala Leu Asn Arg Thr Leu
                 85                  90                  95
 
tct gat ttg cag gtt gat tat gtc gac ttg ttt ctt att cat ttc ccg   336
Ser Asp Leu Gln Val Asp Tyr Val Asp Leu Phe Leu Ile His Phe Pro
            100                 105                 110
 
gtt acc ttt aaa ttt gtt ccg cta gaa gaa aaa tat ccg cct ggt ttt   384
Val Thr Phe Lys Phe Val Pro Leu Glu Glu Lys Tyr Pro Pro Gly Phe
        115                 120                 125
 
tat tgt ggt aag ggt gat aat ttt gat tat gaa gat gtt ccg att ttg   432
Tyr Cys Gly Lys Gly Asp Asn Phe Asp Tyr Glu Asp Val Pro Ile Leu
    130                 135                 140
 
gaa acc tgg aaa gct ctt gaa aaa ctg gtt aaa gct ggt aaa att cgt   480
Glu Thr Trp Lys Ala Leu Glu Lys Leu Val Lys Ala Gly Lys Ile Arg
145                 150                 155                 160
 
tct att ggt gtt tct aat ttt cct ggg gcg ttg ttg ttg gat ttg ttg   528
Ser Ile Gly Val Ser Asn Phe Pro Gly Ala Leu Leu Leu Asp Leu Leu
                165                 170                 175
 
cgt ggt gct aca att aaa ccg tct gtc ctg caa gtc gaa cat cat ccg   576
Arg Gly Ala Thr Ile Lys Pro Ser Val Leu Gln Val Glu His His Pro
            180                 185                 190
 
tat ttg cag cag ccg cgt ttg att gaa ttt gcc cag tct cgt ggc att   624
Tyr Leu Gln Gln Pro Arg Leu Ile Glu Phe Ala Gln Ser Arg Gly Ile
        195                 200                 205
 
gcc gtt acc gct tat tct tct ttt ggt cca cag tct ttt gtt gaa ttg   672
Ala Val Thr Ala Tyr Ser Ser Phe Gly Pro Gln Ser Phe Val Glu Leu
    210                 215                 220
 
aat cag ggt cgt gct ctt aat acc tct ccg ttg ttt gaa aat gaa acc   720
Asn Gln Gly Arg Ala Leu Asn Thr Ser Pro Leu Phe Glu Asn Glu Thr
225                 230                 235                 240
 
att aaa gcc ata gct gcc aaa cat ggt aaa tct ccg gct cag gtt ttg   768
Ile Lys Ala Ile Ala Ala Lys His Gly Lys Ser Pro Ala Gln Val Leu
                245                 250                 255
 
ttg aga tgg tct tct cag cga gga att gcc att att ccg aaa tct aat   816
Leu Arg Trp Ser Ser Gln Arg Gly Ile Ala Ile Ile Pro Lys Ser Asn
            260                 265                 270
 
acc gtt ccg aga cta ttg gaa aat aaa gat gtt aat tct ttt gat ttg   864
Thr Val Pro Arg Leu Leu Glu Asn Lys Asp Val Asn Ser Phe Asp Leu
        275                 280                 285
 
gat gaa cag gat ttt gcc gac att gcc aaa ttg gac att aat ttg cgt   912
Asp Glu Gln Asp Phe Ala Asp Ile Ala Lys Leu Asp Ile Asn Leu Arg
    290                 295                 300
 
ttt aat gat ccg tgg gat tgg gat aaa att ccg att ttt gtt           954
Phe Asn Asp Pro Trp Asp Trp Asp Lys Ile Pro Ile Phe Val
305                 310                 315
 


<210> 24
<211> 318
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in Z. mobilis

<400> 24
Met Pro Ser Ile Lys Leu Asn Ser Gly Tyr Asp Met Pro Ala Val Gly
 1               5                  10                  15      
Phe Gly Cys Trp Lys Val Asp Val Asp Thr Cys Ser Glu Gln Ile Tyr
            20                  25                  30          
Arg Ala Ile Lys Thr Gly Tyr Arg Leu Phe Asp Gly Ala Glu Asp Tyr
        35                  40                  45              
Ala Asn Glu Lys Leu Val Gly Ala Gly Val Lys Lys Ala Ile Asp Glu
    50                  55                  60                  
Gly Ile Val Lys Arg Glu Asp Leu Phe Leu Thr Ser Lys Leu Trp Asn
65                  70                  75                  80  
Asn Tyr His His Pro Asp Asn Val Glu Lys Ala Leu Asn Arg Thr Leu
                85                  90                  95      
Ser Asp Leu Gln Val Asp Tyr Val Asp Leu Phe Leu Ile His Phe Pro
            100                 105                 110         
Val Thr Phe Lys Phe Val Pro Leu Glu Glu Lys Tyr Pro Pro Gly Phe
        115                 120                 125             
Tyr Cys Gly Lys Gly Asp Asn Phe Asp Tyr Glu Asp Val Pro Ile Leu
    130                 135                 140                 
Glu Thr Trp Lys Ala Leu Glu Lys Leu Val Lys Ala Gly Lys Ile Arg
145                 150                 155                 160 
Ser Ile Gly Val Ser Asn Phe Pro Gly Ala Leu Leu Leu Asp Leu Leu
                165                 170                 175     
Arg Gly Ala Thr Ile Lys Pro Ser Val Leu Gln Val Glu His His Pro
            180                 185                 190         
Tyr Leu Gln Gln Pro Arg Leu Ile Glu Phe Ala Gln Ser Arg Gly Ile
        195                 200                 205             
Ala Val Thr Ala Tyr Ser Ser Phe Gly Pro Gln Ser Phe Val Glu Leu
    210                 215                 220                 
Asn Gln Gly Arg Ala Leu Asn Thr Ser Pro Leu Phe Glu Asn Glu Thr
225                 230                 235                 240 
Ile Lys Ala Ile Ala Ala Lys His Gly Lys Ser Pro Ala Gln Val Leu
                245                 250                 255     
Leu Arg Trp Ser Ser Gln Arg Gly Ile Ala Ile Ile Pro Lys Ser Asn
            260                 265                 270         
Thr Val Pro Arg Leu Leu Glu Asn Lys Asp Val Asn Ser Phe Asp Leu
        275                 280                 285             
Asp Glu Gln Asp Phe Ala Asp Ile Ala Lys Leu Asp Ile Asn Leu Arg
    290                 295                 300                 
Phe Asn Asp Pro Trp Asp Trp Asp Lys Ile Pro Ile Phe Val
305                 310                 315             


<210> 25
<211> 975
<212> DNA
<213> C. parapsilosis

<220> 
<221> CDS            
<222> (1)...(975)

<400> 25
atg tct act gct act gct tcc cca gct gtc aaa ttg aac tcc ggc tac   48
Met Ser Thr Ala Thr Ala Ser Pro Ala Val Lys Leu Asn Ser Gly Tyr
 1               5                   10                  15
 
gaa atc cca ttg gtt ggt ttc ggc tgc tgg aaa ttg acc aac gac gtt   96
Glu Ile Pro Leu Val Gly Phe Gly Cys Trp Lys Leu Thr Asn Asp Val
             20                  25                  30
 
gct tcc gac cag atc tac aga gcc atc aag tcc ggc tac aga ttg ttc   144
Ala Ser Asp Gln Ile Tyr Arg Ala Ile Lys Ser Gly Tyr Arg Leu Phe
         35                  40                  45
 
gac ggt gcc gag gac tac gcc aac gag cag gaa gtc ggt gaa ggt atc   192
Asp Gly Ala Glu Asp Tyr Ala Asn Glu Gln Glu Val Gly Glu Gly Ile
     50                  55                  60
 
aaa aga gcc atc aag gaa ggc atc gtc aag aga gaa gag ttg ttc att   240
Lys Arg Ala Ile Lys Glu Gly Ile Val Lys Arg Glu Glu Leu Phe Ile
 65                  70                  75                  80
 
acc tcc aag tta tgg aac tcc ttc cac gac aag aag aac gtc gag gtc   288
Thr Ser Lys Leu Trp Asn Ser Phe His Asp Lys Lys Asn Val Glu Val
                 85                  90                  95
 
gct ttg atg aag acc ttg agc gac ttg aac ttg gac tac gtc gac ttg   336
Ala Leu Met Lys Thr Leu Ser Asp Leu Asn Leu Asp Tyr Val Asp Leu
            100                 105                 110
 
ttc tac atc cac ttc cca att gct cag aag cca gtc cca att gaa aag   384
Phe Tyr Ile His Phe Pro Ile Ala Gln Lys Pro Val Pro Ile Glu Lys
        115                 120                 125
 
aaa tac cca cct ggc ttc tac tgc gga gac ggc gac aag tgg agc atc   432
Lys Tyr Pro Pro Gly Phe Tyr Cys Gly Asp Gly Asp Lys Trp Ser Ile
    130                 135                 140
 
gaa gaa gtc cca ttg ttg gac acc tgg aga gct ttg gag aag ttg gtt   480
Glu Glu Val Pro Leu Leu Asp Thr Trp Arg Ala Leu Glu Lys Leu Val
145                 150                 155                 160
 
gac cag ggc ttg gct aag tcc atc ggt atc tcc aac ttc agc gct cag   528
Asp Gln Gly Leu Ala Lys Ser Ile Gly Ile Ser Asn Phe Ser Ala Gln
                165                 170                 175
 
ttg atc tac gac ttg atc agg ggc tgt acc atc aag ccc gtc gcc ttg   576
Leu Ile Tyr Asp Leu Ile Arg Gly Cys Thr Ile Lys Pro Val Ala Leu
            180                 185                 190
 
cag atc gaa cac cac cca tac ttg acc cag cca aag ttg gtc gag tac   624
Gln Ile Glu His His Pro Tyr Leu Thr Gln Pro Lys Leu Val Glu Tyr
        195                 200                 205
 
gtc cag ttg cac gac atc cag atc acc ggg tac tcc tcc ttc ggt cca   672
Val Gln Leu His Asp Ile Gln Ile Thr Gly Tyr Ser Ser Phe Gly Pro
    210                 215                 220
 
cag tcc ttc ttg gag atg gac ttg aag aga gcc ttg gac acc cct gtc   720
Gln Ser Phe Leu Glu Met Asp Leu Lys Arg Ala Leu Asp Thr Pro Val
225                 230                 235                 240
 
ttg ttg gag gag cca acg gtc aag tcc att gcc gac aag cac ggc aag   768
Leu Leu Glu Glu Pro Thr Val Lys Ser Ile Ala Asp Lys His Gly Lys
                245                 250                 255
 
tcg cca gcc cag gtc ttg ttg aga tat cag acc cag aga ggc atc gct   816
Ser Pro Ala Gln Val Leu Leu Arg Tyr Gln Thr Gln Arg Gly Ile Ala
            260                 265                 270
 
gtc att cca aga tcc aac tcc cca gac aga atg gct cag aac ttg tct   864
Val Ile Pro Arg Ser Asn Ser Pro Asp Arg Met Ala Gln Asn Leu Ser
        275                 280                 285
 
gtc att gac ttt gag ttg acc cag gac gac ttg cag gcc att gcc gag   912
Val Ile Asp Phe Glu Leu Thr Gln Asp Asp Leu Gln Ala Ile Ala Glu
    290                 295                 300
 
ttg gac tgt aac ttg aga ttc aac gag cca tgg gac ttc tcc aac att   960
Leu Asp Cys Asn Leu Arg Phe Asn Glu Pro Trp Asp Phe Ser Asn Ile
305                 310                 315                 320
 
cca gtt ttt gtt taa                                               975
Pro Val Phe Val  *

 

<210> 26
<211> 324
<212> PRT
<213> C. parapsilosis

<400> 26
Met Ser Thr Ala Thr Ala Ser Pro Ala Val Lys Leu Asn Ser Gly Tyr
 1               5                  10                  15      
Glu Ile Pro Leu Val Gly Phe Gly Cys Trp Lys Leu Thr Asn Asp Val
            20                  25                  30          
Ala Ser Asp Gln Ile Tyr Arg Ala Ile Lys Ser Gly Tyr Arg Leu Phe
        35                  40                  45              
Asp Gly Ala Glu Asp Tyr Ala Asn Glu Gln Glu Val Gly Glu Gly Ile
    50                  55                  60                  
Lys Arg Ala Ile Lys Glu Gly Ile Val Lys Arg Glu Glu Leu Phe Ile
65                  70                  75                  80  
Thr Ser Lys Leu Trp Asn Ser Phe His Asp Lys Lys Asn Val Glu Val
                85                  90                  95      
Ala Leu Met Lys Thr Leu Ser Asp Leu Asn Leu Asp Tyr Val Asp Leu
            100                 105                 110         
Phe Tyr Ile His Phe Pro Ile Ala Gln Lys Pro Val Pro Ile Glu Lys
        115                 120                 125             
Lys Tyr Pro Pro Gly Phe Tyr Cys Gly Asp Gly Asp Lys Trp Ser Ile
    130                 135                 140                 
Glu Glu Val Pro Leu Leu Asp Thr Trp Arg Ala Leu Glu Lys Leu Val
145                 150                 155                 160 
Asp Gln Gly Leu Ala Lys Ser Ile Gly Ile Ser Asn Phe Ser Ala Gln
                165                 170                 175     
Leu Ile Tyr Asp Leu Ile Arg Gly Cys Thr Ile Lys Pro Val Ala Leu
            180                 185                 190         
Gln Ile Glu His His Pro Tyr Leu Thr Gln Pro Lys Leu Val Glu Tyr
        195                 200                 205             
Val Gln Leu His Asp Ile Gln Ile Thr Gly Tyr Ser Ser Phe Gly Pro
    210                 215                 220                 
Gln Ser Phe Leu Glu Met Asp Leu Lys Arg Ala Leu Asp Thr Pro Val
225                 230                 235                 240 
Leu Leu Glu Glu Pro Thr Val Lys Ser Ile Ala Asp Lys His Gly Lys
                245                 250                 255     
Ser Pro Ala Gln Val Leu Leu Arg Tyr Gln Thr Gln Arg Gly Ile Ala
            260                 265                 270         
Val Ile Pro Arg Ser Asn Ser Pro Asp Arg Met Ala Gln Asn Leu Ser
        275                 280                 285             
Val Ile Asp Phe Glu Leu Thr Gln Asp Asp Leu Gln Ala Ile Ala Glu
    290                 295                 300                 
Leu Asp Cys Asn Leu Arg Phe Asn Glu Pro Trp Asp Phe Ser Asn Ile
305                 310                 315                 320 
Pro Val Phe Val
                


<210> 27
<211> 972
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in S. cerevisiae

<220> 
<221> CDS            
<222> (1)...(972)

<400> 27
atg tca act gct acc gct tct cct gcc gtt aaa tta aat tct ggt tat   48
Met Ser Thr Ala Thr Ala Ser Pro Ala Val Lys Leu Asn Ser Gly Tyr
 1               5                   10                  15
 
gaa att cca ttg gtt ggt ttt gga tgt tgg aaa ttg act aat gac gtt   96
Glu Ile Pro Leu Val Gly Phe Gly Cys Trp Lys Leu Thr Asn Asp Val
             20                  25                  30
 
gct tct gat caa att tat aga gct att aaa tct ggt tac agg ttg ttt   144
Ala Ser Asp Gln Ile Tyr Arg Ala Ile Lys Ser Gly Tyr Arg Leu Phe
         35                  40                  45
 
gat ggt gcg gaa gat tat gct aat gaa caa gaa gtt ggt gag gga att   192
Asp Gly Ala Glu Asp Tyr Ala Asn Glu Gln Glu Val Gly Glu Gly Ile
     50                  55                  60
 
aaa aga gca att aaa gaa gga att gtt aaa aga gaa gaa ttg ttt att   240
Lys Arg Ala Ile Lys Glu Gly Ile Val Lys Arg Glu Glu Leu Phe Ile
 65                  70                  75                  80
 
act tct aaa ttg tgg aat agt ttt cat gat aaa aag aat gtt gaa gtt   288
Thr Ser Lys Leu Trp Asn Ser Phe His Asp Lys Lys Asn Val Glu Val
                 85                  90                  95
 
gct ttg atg aaa aca ttg tct gat tta aat ttg gat tat gtt gat ttg   336
Ala Leu Met Lys Thr Leu Ser Asp Leu Asn Leu Asp Tyr Val Asp Leu
            100                 105                 110
 
ttt tat att cat ttt cct att gct caa aaa cca gtt cca att gag aaa   384
Phe Tyr Ile His Phe Pro Ile Ala Gln Lys Pro Val Pro Ile Glu Lys
        115                 120                 125
 
aag tat cct ccg ggt ttt tat tgt ggt gat ggt gat aaa tgg tct att   432
Lys Tyr Pro Pro Gly Phe Tyr Cys Gly Asp Gly Asp Lys Trp Ser Ile
    130                 135                 140
 
gaa gaa gta cca cta tta gat act tgg agg gca ttg gaa aaa ttg gtt   480
Glu Glu Val Pro Leu Leu Asp Thr Trp Arg Ala Leu Glu Lys Leu Val
145                 150                 155                 160
 
gat caa ggt ttg gct aaa tct att gga att tct aat ttt tct gct caa   528
Asp Gln Gly Leu Ala Lys Ser Ile Gly Ile Ser Asn Phe Ser Ala Gln
                165                 170                 175
 
ttg att tat gat ttg att aga ggt tgt act att aaa cca gtt gct ttg   576
Leu Ile Tyr Asp Leu Ile Arg Gly Cys Thr Ile Lys Pro Val Ala Leu
            180                 185                 190
 
cag att gaa cat cat cca tat ttg act caa cca aaa tta gtt gaa tat   624
Gln Ile Glu His His Pro Tyr Leu Thr Gln Pro Lys Leu Val Glu Tyr
        195                 200                 205
 
gtt caa tta cat gat ata caa att act ggt tat tct tct ttt gga cca   672
Val Gln Leu His Asp Ile Gln Ile Thr Gly Tyr Ser Ser Phe Gly Pro
    210                 215                 220
 
caa tct ttt cta gaa atg gat tta aaa aga gct tta gat act cca gtt   720
Gln Ser Phe Leu Glu Met Asp Leu Lys Arg Ala Leu Asp Thr Pro Val
225                 230                 235                 240
 
tta tta gaa gaa cca act gtt aaa tct att gct gat aaa cat ggt aaa   768
Leu Leu Glu Glu Pro Thr Val Lys Ser Ile Ala Asp Lys His Gly Lys
                245                 250                 255
 
tcc cca gcc caa gtt ttg ttg aga tat cag act caa aga gga att gct   816
Ser Pro Ala Gln Val Leu Leu Arg Tyr Gln Thr Gln Arg Gly Ile Ala
            260                 265                 270
 
gtc att ccc aga tct aat tca cca gat aga atg gct caa aat ttg tct   864
Val Ile Pro Arg Ser Asn Ser Pro Asp Arg Met Ala Gln Asn Leu Ser
        275                 280                 285
 
gta att gat ttt gaa ttg act caa gat gat ttg cag gct ata gct gaa   912
Val Ile Asp Phe Glu Leu Thr Gln Asp Asp Leu Gln Ala Ile Ala Glu
    290                 295                 300
 
ttg gat tgt aat ttg aga ttt aat gaa cca tgg gat ttt tct aat ata   960
Leu Asp Cys Asn Leu Arg Phe Asn Glu Pro Trp Asp Phe Ser Asn Ile
305                 310                 315                 320
 
cca gtt ttt gta                                                   972
Pro Val Phe Val

 

<210> 28
<211> 324
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in S. cerevisiae

<400> 28
Met Ser Thr Ala Thr Ala Ser Pro Ala Val Lys Leu Asn Ser Gly Tyr
 1               5                  10                  15      
Glu Ile Pro Leu Val Gly Phe Gly Cys Trp Lys Leu Thr Asn Asp Val
            20                  25                  30          
Ala Ser Asp Gln Ile Tyr Arg Ala Ile Lys Ser Gly Tyr Arg Leu Phe
        35                  40                  45              
Asp Gly Ala Glu Asp Tyr Ala Asn Glu Gln Glu Val Gly Glu Gly Ile
    50                  55                  60                  
Lys Arg Ala Ile Lys Glu Gly Ile Val Lys Arg Glu Glu Leu Phe Ile
65                  70                  75                  80  
Thr Ser Lys Leu Trp Asn Ser Phe His Asp Lys Lys Asn Val Glu Val
                85                  90                  95      
Ala Leu Met Lys Thr Leu Ser Asp Leu Asn Leu Asp Tyr Val Asp Leu
            100                 105                 110         
Phe Tyr Ile His Phe Pro Ile Ala Gln Lys Pro Val Pro Ile Glu Lys
        115                 120                 125             
Lys Tyr Pro Pro Gly Phe Tyr Cys Gly Asp Gly Asp Lys Trp Ser Ile
    130                 135                 140                 
Glu Glu Val Pro Leu Leu Asp Thr Trp Arg Ala Leu Glu Lys Leu Val
145                 150                 155                 160 
Asp Gln Gly Leu Ala Lys Ser Ile Gly Ile Ser Asn Phe Ser Ala Gln
                165                 170                 175     
Leu Ile Tyr Asp Leu Ile Arg Gly Cys Thr Ile Lys Pro Val Ala Leu
            180                 185                 190         
Gln Ile Glu His His Pro Tyr Leu Thr Gln Pro Lys Leu Val Glu Tyr
        195                 200                 205             
Val Gln Leu His Asp Ile Gln Ile Thr Gly Tyr Ser Ser Phe Gly Pro
    210                 215                 220                 
Gln Ser Phe Leu Glu Met Asp Leu Lys Arg Ala Leu Asp Thr Pro Val
225                 230                 235                 240 
Leu Leu Glu Glu Pro Thr Val Lys Ser Ile Ala Asp Lys His Gly Lys
                245                 250                 255     
Ser Pro Ala Gln Val Leu Leu Arg Tyr Gln Thr Gln Arg Gly Ile Ala
            260                 265                 270         
Val Ile Pro Arg Ser Asn Ser Pro Asp Arg Met Ala Gln Asn Leu Ser
        275                 280                 285             
Val Ile Asp Phe Glu Leu Thr Gln Asp Asp Leu Gln Ala Ile Ala Glu
    290                 295                 300                 
Leu Asp Cys Asn Leu Arg Phe Asn Glu Pro Trp Asp Phe Ser Asn Ile
305                 310                 315                 320 
Pro Val Phe Val
                


<210> 29
<211> 994
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in S. cerevisiae

<220> 
<221> CDS            
<222> (12)...(983)

<400> 29
tactcaagct t atg tca act gct acc gct tct cct gcc gtt aaa tta aat  50
             Met Ser Thr Ala Thr Ala Ser Pro Ala Val Lys Leu Asn
              1               5                   10
 
tct ggt tat gaa att cca ttg gtt ggt ttt gga tgt tgg aaa ttg act   98
Ser Gly Tyr Glu Ile Pro Leu Val Gly Phe Gly Cys Trp Lys Leu Thr
     15                  20                  25
 
aat gac gtt gct tct gat caa att tat aga gct att aaa tct ggt tac   146
Asn Asp Val Ala Ser Asp Gln Ile Tyr Arg Ala Ile Lys Ser Gly Tyr
 30                  35                  40                  45
 
agg ttg ttt gat ggt gcg gaa gat tat gct aat gaa caa gaa gtt ggt   194
Arg Leu Phe Asp Gly Ala Glu Asp Tyr Ala Asn Glu Gln Glu Val Gly
                 50                  55                  60
 
gag gga att aaa aga gca att aaa gaa gga att gtt aaa aga gaa gaa   242
Glu Gly Ile Lys Arg Ala Ile Lys Glu Gly Ile Val Lys Arg Glu Glu
             65                  70                  75
 
ttg ttt att act tct aaa ttg tgg aat agt ttt cat gat aaa aag aat   290
Leu Phe Ile Thr Ser Lys Leu Trp Asn Ser Phe His Asp Lys Lys Asn
         80                  85                  90
 
gtt gaa gtt gct ttg atg aaa aca ttg tct gat tta aat ttg gat tat   338
Val Glu Val Ala Leu Met Lys Thr Leu Ser Asp Leu Asn Leu Asp Tyr
     95                 100                 105
 
gtt gat ttg ttt tat att cat ttt cct att gct caa aaa cca gtt cca   386
Val Asp Leu Phe Tyr Ile His Phe Pro Ile Ala Gln Lys Pro Val Pro
110                 115                 120                 125
 
att gag aaa aag tat cct ccg ggt ttt tat tgt ggt gat ggt gat aaa   434
Ile Glu Lys Lys Tyr Pro Pro Gly Phe Tyr Cys Gly Asp Gly Asp Lys
                130                 135                 140
 
tgg tct att gaa gaa gta cca cta tta gat act tgg agg gca ttg gaa   482
Trp Ser Ile Glu Glu Val Pro Leu Leu Asp Thr Trp Arg Ala Leu Glu
            145                 150                 155
 
aaa ttg gtt gat caa ggt ttg gct aaa tct att gga att tct aat ttt   530
Lys Leu Val Asp Gln Gly Leu Ala Lys Ser Ile Gly Ile Ser Asn Phe
        160                 165                 170
 
tct gct caa ttg att tat gat ttg att aga ggt tgt act att aaa cca   578
Ser Ala Gln Leu Ile Tyr Asp Leu Ile Arg Gly Cys Thr Ile Lys Pro
    175                 180                 185
 
gtt gct ttg cag att gaa cat cat cca tat ttg act caa cca aaa tta   626
Val Ala Leu Gln Ile Glu His His Pro Tyr Leu Thr Gln Pro Lys Leu
190                 195                 200                 205
 
gtt gaa tat gtt caa tta cat gat ata caa att act ggt tat tct tct   674
Val Glu Tyr Val Gln Leu His Asp Ile Gln Ile Thr Gly Tyr Ser Ser
                210                 215                 220
 
ttt gga cca caa tct ttt cta gaa atg gat tta aaa aga gct tta gat   722
Phe Gly Pro Gln Ser Phe Leu Glu Met Asp Leu Lys Arg Ala Leu Asp
            225                 230                 235
 
act cca gtt tta tta gaa gaa cca act gtt aaa tct att gct gat aaa   770
Thr Pro Val Leu Leu Glu Glu Pro Thr Val Lys Ser Ile Ala Asp Lys
        240                 245                 250
 
cat ggt aaa tcc cca gcc caa gtt ttg ttg aga tat cag act caa aga   818
His Gly Lys Ser Pro Ala Gln Val Leu Leu Arg Tyr Gln Thr Gln Arg
    255                 260                 265
 
gga att gct gtc att ccc aga tct aat tca cca gat aga atg gct caa   866
Gly Ile Ala Val Ile Pro Arg Ser Asn Ser Pro Asp Arg Met Ala Gln
270                 275                 280                 285
 
aat ttg tct gta att gat ttt gaa ttg act caa gat gat ttg cag gct   914
Asn Leu Ser Val Ile Asp Phe Glu Leu Thr Gln Asp Asp Leu Gln Ala
                290                 295                 300
 
ata gct gaa ttg gat tgt aat ttg aga ttt aat gaa cca tgg gat ttt   962
Ile Ala Glu Leu Asp Cys Asn Leu Arg Phe Asn Glu Pro Trp Asp Phe
            305                 310                 315
 
tct aat ata cca gtt ttt gta gaattccgat g                          994
Ser Asn Ile Pro Val Phe Val
        320
 

<210> 30
<211> 324
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in S. cerevisiae

<400> 30
Met Ser Thr Ala Thr Ala Ser Pro Ala Val Lys Leu Asn Ser Gly Tyr
 1               5                  10                  15      
Glu Ile Pro Leu Val Gly Phe Gly Cys Trp Lys Leu Thr Asn Asp Val
            20                  25                  30          
Ala Ser Asp Gln Ile Tyr Arg Ala Ile Lys Ser Gly Tyr Arg Leu Phe
        35                  40                  45              
Asp Gly Ala Glu Asp Tyr Ala Asn Glu Gln Glu Val Gly Glu Gly Ile
    50                  55                  60                  
Lys Arg Ala Ile Lys Glu Gly Ile Val Lys Arg Glu Glu Leu Phe Ile
65                  70                  75                  80  
Thr Ser Lys Leu Trp Asn Ser Phe His Asp Lys Lys Asn Val Glu Val
                85                  90                  95      
Ala Leu Met Lys Thr Leu Ser Asp Leu Asn Leu Asp Tyr Val Asp Leu
            100                 105                 110         
Phe Tyr Ile His Phe Pro Ile Ala Gln Lys Pro Val Pro Ile Glu Lys
        115                 120                 125             
Lys Tyr Pro Pro Gly Phe Tyr Cys Gly Asp Gly Asp Lys Trp Ser Ile
    130                 135                 140                 
Glu Glu Val Pro Leu Leu Asp Thr Trp Arg Ala Leu Glu Lys Leu Val
145                 150                 155                 160 
Asp Gln Gly Leu Ala Lys Ser Ile Gly Ile Ser Asn Phe Ser Ala Gln
                165                 170                 175     
Leu Ile Tyr Asp Leu Ile Arg Gly Cys Thr Ile Lys Pro Val Ala Leu
            180                 185                 190         
Gln Ile Glu His His Pro Tyr Leu Thr Gln Pro Lys Leu Val Glu Tyr
        195                 200                 205             
Val Gln Leu His Asp Ile Gln Ile Thr Gly Tyr Ser Ser Phe Gly Pro
    210                 215                 220                 
Gln Ser Phe Leu Glu Met Asp Leu Lys Arg Ala Leu Asp Thr Pro Val
225                 230                 235                 240 
Leu Leu Glu Glu Pro Thr Val Lys Ser Ile Ala Asp Lys His Gly Lys
                245                 250                 255     
Ser Pro Ala Gln Val Leu Leu Arg Tyr Gln Thr Gln Arg Gly Ile Ala
            260                 265                 270         
Val Ile Pro Arg Ser Asn Ser Pro Asp Arg Met Ala Gln Asn Leu Ser
        275                 280                 285             
Val Ile Asp Phe Glu Leu Thr Gln Asp Asp Leu Gln Ala Ile Ala Glu
    290                 295                 300                 
Leu Asp Cys Asn Leu Arg Phe Asn Glu Pro Trp Asp Phe Ser Asn Ile
305                 310                 315                 320 
Pro Val Phe Val
                


<210> 31
<211> 1000
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in S. cerevisiae

<220> 
<221> CDS            
<222> (15)...(986)

<400> 31
gaatactcca tatg atg tca act gct acc gct tct cct gcc gtt aaa tta   50
                Met Ser Thr Ala Thr Ala Ser Pro Ala Val Lys Leu
                 1               5                   10
 
aat tct ggt tat gaa att cca ttg gtt ggt ttt gga tgt tgg aaa ttg   98
Asn Ser Gly Tyr Glu Ile Pro Leu Val Gly Phe Gly Cys Trp Lys Leu
         15                  20                  25
 
act aat gac gtt gct tct gat caa att tat aga gct att aaa tct ggt   146
Thr Asn Asp Val Ala Ser Asp Gln Ile Tyr Arg Ala Ile Lys Ser Gly
     30                  35                  40
 
tac agg ttg ttt gat ggt gcg gaa gat tat gct aat gaa caa gaa gtt   194
Tyr Arg Leu Phe Asp Gly Ala Glu Asp Tyr Ala Asn Glu Gln Glu Val
 45                  50                  55                  60
 
ggt gag gga att aaa aga gca att aaa gaa gga att gtt aaa aga gaa   242
Gly Glu Gly Ile Lys Arg Ala Ile Lys Glu Gly Ile Val Lys Arg Glu
                 65                  70                  75
 
gaa ttg ttt att act tct aaa ttg tgg aat agt ttt cat gat aaa aag   290
Glu Leu Phe Ile Thr Ser Lys Leu Trp Asn Ser Phe His Asp Lys Lys
             80                  85                  90
 
aat gtt gaa gtt gct ttg atg aaa aca ttg tct gat tta aat ttg gat   338
Asn Val Glu Val Ala Leu Met Lys Thr Leu Ser Asp Leu Asn Leu Asp
         95                 100                 105
 
tat gtt gat ttg ttt tat att cat ttt cct att gct caa aaa cca gtt   386
Tyr Val Asp Leu Phe Tyr Ile His Phe Pro Ile Ala Gln Lys Pro Val
    110                 115                 120
 
cca att gag aaa aag tat cct ccg ggt ttt tat tgt ggt gat ggt gat   434
Pro Ile Glu Lys Lys Tyr Pro Pro Gly Phe Tyr Cys Gly Asp Gly Asp
125                 130                 135                 140
 
aaa tgg tct att gaa gaa gta cca cta tta gat act tgg agg gca ttg   482
Lys Trp Ser Ile Glu Glu Val Pro Leu Leu Asp Thr Trp Arg Ala Leu
                145                 150                 155
 
gaa aaa ttg gtt gat caa ggt ttg gct aaa tct att gga att tct aat   530
Glu Lys Leu Val Asp Gln Gly Leu Ala Lys Ser Ile Gly Ile Ser Asn
            160                 165                 170
 
ttt tct gct caa ttg att tat gat ttg att aga ggt tgt act att aaa   578
Phe Ser Ala Gln Leu Ile Tyr Asp Leu Ile Arg Gly Cys Thr Ile Lys
        175                 180                 185
 
cca gtt gct ttg cag att gaa cat cat cca tat ttg act caa cca aaa   626
Pro Val Ala Leu Gln Ile Glu His His Pro Tyr Leu Thr Gln Pro Lys
    190                 195                 200
 
tta gtt gaa tat gtt caa tta cat gat ata caa att act ggt tat tct   674
Leu Val Glu Tyr Val Gln Leu His Asp Ile Gln Ile Thr Gly Tyr Ser
205                 210                 215                 220
 
tct ttt gga cca caa tct ttt cta gaa atg gat tta aaa aga gct tta   722
Ser Phe Gly Pro Gln Ser Phe Leu Glu Met Asp Leu Lys Arg Ala Leu
                225                 230                 235
 
gat act cca gtt tta tta gaa gaa cca act gtt aaa tct att gct gat   770
Asp Thr Pro Val Leu Leu Glu Glu Pro Thr Val Lys Ser Ile Ala Asp
            240                 245                 250
 
aaa cat ggt aaa tcc cca gcc caa gtt ttg ttg aga tat cag act caa   818
Lys His Gly Lys Ser Pro Ala Gln Val Leu Leu Arg Tyr Gln Thr Gln
        255                 260                 265
 
aga gga att gct gtc att ccc aga tct aat tca cca gat aga atg gct   866
Arg Gly Ile Ala Val Ile Pro Arg Ser Asn Ser Pro Asp Arg Met Ala
    270                 275                 280
 
caa aat ttg tct gta att gat ttt gaa ttg act caa gat gat ttg cag   914
Gln Asn Leu Ser Val Ile Asp Phe Glu Leu Thr Gln Asp Asp Leu Gln
285                 290                 295                 300
 
gct ata gct gaa ttg gat tgt aat ttg aga ttt aat gaa cca tgg gat   962
Ala Ile Ala Glu Leu Asp Cys Asn Leu Arg Phe Asn Glu Pro Trp Asp
                305                 310                 315
 
ttt tct aat ata cca gtt ttt gta actagtcagt gcct                   1000
Phe Ser Asn Ile Pro Val Phe Val
            320
 

<210> 32
<211> 324
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in S. cerevisiae

<400> 32
Met Ser Thr Ala Thr Ala Ser Pro Ala Val Lys Leu Asn Ser Gly Tyr
 1               5                  10                  15      
Glu Ile Pro Leu Val Gly Phe Gly Cys Trp Lys Leu Thr Asn Asp Val
            20                  25                  30          
Ala Ser Asp Gln Ile Tyr Arg Ala Ile Lys Ser Gly Tyr Arg Leu Phe
        35                  40                  45              
Asp Gly Ala Glu Asp Tyr Ala Asn Glu Gln Glu Val Gly Glu Gly Ile
    50                  55                  60                  
Lys Arg Ala Ile Lys Glu Gly Ile Val Lys Arg Glu Glu Leu Phe Ile
65                  70                  75                  80  
Thr Ser Lys Leu Trp Asn Ser Phe His Asp Lys Lys Asn Val Glu Val
                85                  90                  95      
Ala Leu Met Lys Thr Leu Ser Asp Leu Asn Leu Asp Tyr Val Asp Leu
            100                 105                 110         
Phe Tyr Ile His Phe Pro Ile Ala Gln Lys Pro Val Pro Ile Glu Lys
        115                 120                 125             
Lys Tyr Pro Pro Gly Phe Tyr Cys Gly Asp Gly Asp Lys Trp Ser Ile
    130                 135                 140                 
Glu Glu Val Pro Leu Leu Asp Thr Trp Arg Ala Leu Glu Lys Leu Val
145                 150                 155                 160 
Asp Gln Gly Leu Ala Lys Ser Ile Gly Ile Ser Asn Phe Ser Ala Gln
                165                 170                 175     
Leu Ile Tyr Asp Leu Ile Arg Gly Cys Thr Ile Lys Pro Val Ala Leu
            180                 185                 190         
Gln Ile Glu His His Pro Tyr Leu Thr Gln Pro Lys Leu Val Glu Tyr
        195                 200                 205             
Val Gln Leu His Asp Ile Gln Ile Thr Gly Tyr Ser Ser Phe Gly Pro
    210                 215                 220                 
Gln Ser Phe Leu Glu Met Asp Leu Lys Arg Ala Leu Asp Thr Pro Val
225                 230                 235                 240 
Leu Leu Glu Glu Pro Thr Val Lys Ser Ile Ala Asp Lys His Gly Lys
                245                 250                 255     
Ser Pro Ala Gln Val Leu Leu Arg Tyr Gln Thr Gln Arg Gly Ile Ala
            260                 265                 270         
Val Ile Pro Arg Ser Asn Ser Pro Asp Arg Met Ala Gln Asn Leu Ser
        275                 280                 285             
Val Ile Asp Phe Glu Leu Thr Gln Asp Asp Leu Gln Ala Ile Ala Glu
    290                 295                 300                 
Leu Asp Cys Asn Leu Arg Phe Asn Glu Pro Trp Asp Phe Ser Asn Ile
305                 310                 315                 320 
Pro Val Phe Val
                


<210> 33
<211> 972
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in E. coli

<220> 
<221> CDS            
<222> (1)...(972)

<400> 33
atg tct acc gcg act gca tct ccg gct gtt aaa ctg aac tct ggt tac   48
Met Ser Thr Ala Thr Ala Ser Pro Ala Val Lys Leu Asn Ser Gly Tyr
 1               5                   10                  15
 
gaa atc ccg ctg gtt ggt ttc ggt tgc tgg aaa ctg acc aac gac gtt   96
Glu Ile Pro Leu Val Gly Phe Gly Cys Trp Lys Leu Thr Asn Asp Val
             20                  25                  30
 
gct tct gac cag atc tac cgt gcg att aaa tct ggc tac cgt ctg ttc   144
Ala Ser Asp Gln Ile Tyr Arg Ala Ile Lys Ser Gly Tyr Arg Leu Phe
         35                  40                  45
 
gat ggt gcg gag gac tat gcg aac gaa cag gaa gtt ggt gaa ggt atc   192
Asp Gly Ala Glu Asp Tyr Ala Asn Glu Gln Glu Val Gly Glu Gly Ile
     50                  55                  60
 
aaa cgt gct atc aaa gaa ggt atc gtt aaa cgt gaa gaa ctg ttc atc   240
Lys Arg Ala Ile Lys Glu Gly Ile Val Lys Arg Glu Glu Leu Phe Ile
 65                  70                  75                  80
 
acc tct aaa ctg tgg aac tct ttc cat gac aaa aag aac gtt gaa gtt   288
Thr Ser Lys Leu Trp Asn Ser Phe His Asp Lys Lys Asn Val Glu Val
                 85                  90                  95
 
gct ctg atg aaa acc ctg tct gac ctg aac ctg gac tac gtt gac ctg   336
Ala Leu Met Lys Thr Leu Ser Asp Leu Asn Leu Asp Tyr Val Asp Leu
            100                 105                 110
 
ttc tac atc cac ttc cca atc gcg cag aaa ccg gtg ccg atc gaa aag   384
Phe Tyr Ile His Phe Pro Ile Ala Gln Lys Pro Val Pro Ile Glu Lys
        115                 120                 125
 
aag tac ccg cca ggt ttc tac tgt ggt gac ggt gac aaa tgg tct atc   432
Lys Tyr Pro Pro Gly Phe Tyr Cys Gly Asp Gly Asp Lys Trp Ser Ile
    130                 135                 140
 
gaa gaa gtt ccg ctg ctg gac act tgg cgt gcg ctc gaa aag ctg gtt   480
Glu Glu Val Pro Leu Leu Asp Thr Trp Arg Ala Leu Glu Lys Leu Val
145                 150                 155                 160
 
gat cag ggt ctg gct aaa tct atc ggt atc tct aac ttc tct gct cag   528
Asp Gln Gly Leu Ala Lys Ser Ile Gly Ile Ser Asn Phe Ser Ala Gln
                165                 170                 175
 
ctg atc tac gac ctg atc cgt ggc tgc acc atc aaa ccg gtt gcg ctc   576
Leu Ile Tyr Asp Leu Ile Arg Gly Cys Thr Ile Lys Pro Val Ala Leu
            180                 185                 190
 
cag atc gaa cac cac ccg tac ctg acc cag ccg aaa ctg gtt gaa tac   624
Gln Ile Glu His His Pro Tyr Leu Thr Gln Pro Lys Leu Val Glu Tyr
        195                 200                 205
 
gtt caa ctg cat gac atc cag atc acc ggt tac tct tct ttc ggt ccg   672
Val Gln Leu His Asp Ile Gln Ile Thr Gly Tyr Ser Ser Phe Gly Pro
    210                 215                 220
 
cag tct ttc ttg gaa atg gac ctg aaa cgt gcg ttg gac acc cca gtt   720
Gln Ser Phe Leu Glu Met Asp Leu Lys Arg Ala Leu Asp Thr Pro Val
225                 230                 235                 240
 
ctg ctc gaa gaa ccg acc gtt aaa tct att gcg gac aaa cac ggt aaa   768
Leu Leu Glu Glu Pro Thr Val Lys Ser Ile Ala Asp Lys His Gly Lys
                245                 250                 255
 
tct ccg gct cag gtt ctc ttg cgt tat caa act caa cgt ggt atc gct   816
Ser Pro Ala Gln Val Leu Leu Arg Tyr Gln Thr Gln Arg Gly Ile Ala
            260                 265                 270
 
gtt atc ccg cgc agc aac tct ccg gac cgt atg gct cag aac ctg tct   864
Val Ile Pro Arg Ser Asn Ser Pro Asp Arg Met Ala Gln Asn Leu Ser
        275                 280                 285
 
gtt att gac ttc gaa ctg acc cag gac gac ctc cag gct atc gcg gaa   912
Val Ile Asp Phe Glu Leu Thr Gln Asp Asp Leu Gln Ala Ile Ala Glu
    290                 295                 300
 
ctg gac tgc aac ctg cgt ttc aac gaa ccg tgg gac ttc tct aac atc   960
Leu Asp Cys Asn Leu Arg Phe Asn Glu Pro Trp Asp Phe Ser Asn Ile
305                 310                 315                 320
 
ccg gtt ttc gtt                                                   972
Pro Val Phe Val

 

<210> 34
<211> 324
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in E. coli

<400> 34
Met Ser Thr Ala Thr Ala Ser Pro Ala Val Lys Leu Asn Ser Gly Tyr
 1               5                  10                  15      
Glu Ile Pro Leu Val Gly Phe Gly Cys Trp Lys Leu Thr Asn Asp Val
            20                  25                  30          
Ala Ser Asp Gln Ile Tyr Arg Ala Ile Lys Ser Gly Tyr Arg Leu Phe
        35                  40                  45              
Asp Gly Ala Glu Asp Tyr Ala Asn Glu Gln Glu Val Gly Glu Gly Ile
    50                  55                  60                  
Lys Arg Ala Ile Lys Glu Gly Ile Val Lys Arg Glu Glu Leu Phe Ile
65                  70                  75                  80  
Thr Ser Lys Leu Trp Asn Ser Phe His Asp Lys Lys Asn Val Glu Val
                85                  90                  95      
Ala Leu Met Lys Thr Leu Ser Asp Leu Asn Leu Asp Tyr Val Asp Leu
            100                 105                 110         
Phe Tyr Ile His Phe Pro Ile Ala Gln Lys Pro Val Pro Ile Glu Lys
        115                 120                 125             
Lys Tyr Pro Pro Gly Phe Tyr Cys Gly Asp Gly Asp Lys Trp Ser Ile
    130                 135                 140                 
Glu Glu Val Pro Leu Leu Asp Thr Trp Arg Ala Leu Glu Lys Leu Val
145                 150                 155                 160 
Asp Gln Gly Leu Ala Lys Ser Ile Gly Ile Ser Asn Phe Ser Ala Gln
                165                 170                 175     
Leu Ile Tyr Asp Leu Ile Arg Gly Cys Thr Ile Lys Pro Val Ala Leu
            180                 185                 190         
Gln Ile Glu His His Pro Tyr Leu Thr Gln Pro Lys Leu Val Glu Tyr
        195                 200                 205             
Val Gln Leu His Asp Ile Gln Ile Thr Gly Tyr Ser Ser Phe Gly Pro
    210                 215                 220                 
Gln Ser Phe Leu Glu Met Asp Leu Lys Arg Ala Leu Asp Thr Pro Val
225                 230                 235                 240 
Leu Leu Glu Glu Pro Thr Val Lys Ser Ile Ala Asp Lys His Gly Lys
                245                 250                 255     
Ser Pro Ala Gln Val Leu Leu Arg Tyr Gln Thr Gln Arg Gly Ile Ala
            260                 265                 270         
Val Ile Pro Arg Ser Asn Ser Pro Asp Arg Met Ala Gln Asn Leu Ser
        275                 280                 285             
Val Ile Asp Phe Glu Leu Thr Gln Asp Asp Leu Gln Ala Ile Ala Glu
    290                 295                 300                 
Leu Asp Cys Asn Leu Arg Phe Asn Glu Pro Trp Asp Phe Ser Asn Ile
305                 310                 315                 320 
Pro Val Phe Val
                


<210> 35
<211> 994
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in E. coli

<220> 
<221> CDS            
<222> (12)...(983)

<400> 35
tactcaagct t atg tct acc gcg act gca tct ccg gct gtt aaa ctg aac  50
             Met Ser Thr Ala Thr Ala Ser Pro Ala Val Lys Leu Asn
              1               5                   10
 
tct ggt tac gaa atc ccg ctg gtt ggt ttc ggt tgc tgg aaa ctg acc   98
Ser Gly Tyr Glu Ile Pro Leu Val Gly Phe Gly Cys Trp Lys Leu Thr
     15                  20                  25
 
aac gac gtt gct tct gac cag atc tac cgt gcg att aaa tct ggc tac   146
Asn Asp Val Ala Ser Asp Gln Ile Tyr Arg Ala Ile Lys Ser Gly Tyr
 30                  35                  40                  45
 
cgt ctg ttc gat ggt gcg gag gac tat gcg aac gaa cag gaa gtt ggt   194
Arg Leu Phe Asp Gly Ala Glu Asp Tyr Ala Asn Glu Gln Glu Val Gly
                 50                  55                  60
 
gaa ggt atc aaa cgt gct atc aaa gaa ggt atc gtt aaa cgt gaa gaa   242
Glu Gly Ile Lys Arg Ala Ile Lys Glu Gly Ile Val Lys Arg Glu Glu
             65                  70                  75
 
ctg ttc atc acc tct aaa ctg tgg aac tct ttc cat gac aaa aag aac   290
Leu Phe Ile Thr Ser Lys Leu Trp Asn Ser Phe His Asp Lys Lys Asn
         80                  85                  90
 
gtt gaa gtt gct ctg atg aaa acc ctg tct gac ctg aac ctg gac tac   338
Val Glu Val Ala Leu Met Lys Thr Leu Ser Asp Leu Asn Leu Asp Tyr
     95                 100                 105
 
gtt gac ctg ttc tac atc cac ttc cca atc gcg cag aaa ccg gtg ccg   386
Val Asp Leu Phe Tyr Ile His Phe Pro Ile Ala Gln Lys Pro Val Pro
110                 115                 120                 125
 
atc gaa aag aag tac ccg cca ggt ttc tac tgt ggt gac ggt gac aaa   434
Ile Glu Lys Lys Tyr Pro Pro Gly Phe Tyr Cys Gly Asp Gly Asp Lys
                130                 135                 140
 
tgg tct atc gaa gaa gtt ccg ctg ctg gac act tgg cgt gcg ctc gaa   482
Trp Ser Ile Glu Glu Val Pro Leu Leu Asp Thr Trp Arg Ala Leu Glu
            145                 150                 155
 
aag ctg gtt gat cag ggt ctg gct aaa tct atc ggt atc tct aac ttc   530
Lys Leu Val Asp Gln Gly Leu Ala Lys Ser Ile Gly Ile Ser Asn Phe
        160                 165                 170
 
tct gct cag ctg atc tac gac ctg atc cgt ggc tgc acc atc aaa ccg   578
Ser Ala Gln Leu Ile Tyr Asp Leu Ile Arg Gly Cys Thr Ile Lys Pro
    175                 180                 185
 
gtt gcg ctc cag atc gaa cac cac ccg tac ctg acc cag ccg aaa ctg   626
Val Ala Leu Gln Ile Glu His His Pro Tyr Leu Thr Gln Pro Lys Leu
190                 195                 200                 205
 
gtt gaa tac gtt caa ctg cat gac atc cag atc acc ggt tac tct tct   674
Val Glu Tyr Val Gln Leu His Asp Ile Gln Ile Thr Gly Tyr Ser Ser
                210                 215                 220
 
ttc ggt ccg cag tct ttc ttg gaa atg gac ctg aaa cgt gcg ttg gac   722
Phe Gly Pro Gln Ser Phe Leu Glu Met Asp Leu Lys Arg Ala Leu Asp
            225                 230                 235
 
acc cca gtt ctg ctc gaa gaa ccg acc gtt aaa tct att gcg gac aaa   770
Thr Pro Val Leu Leu Glu Glu Pro Thr Val Lys Ser Ile Ala Asp Lys
        240                 245                 250
 
cac ggt aaa tct ccg gct cag gtt ctc ttg cgt tat caa act caa cgt   818
His Gly Lys Ser Pro Ala Gln Val Leu Leu Arg Tyr Gln Thr Gln Arg
    255                 260                 265
 
ggt atc gct gtt atc ccg cgc agc aac tct ccg gac cgt atg gct cag   866
Gly Ile Ala Val Ile Pro Arg Ser Asn Ser Pro Asp Arg Met Ala Gln
270                 275                 280                 285
 
aac ctg tct gtt att gac ttc gaa ctg acc cag gac gac ctc cag gct   914
Asn Leu Ser Val Ile Asp Phe Glu Leu Thr Gln Asp Asp Leu Gln Ala
                290                 295                 300
 
atc gcg gaa ctg gac tgc aac ctg cgt ttc aac gaa ccg tgg gac ttc   962
Ile Ala Glu Leu Asp Cys Asn Leu Arg Phe Asn Glu Pro Trp Asp Phe
            305                 310                 315
 
tct aac atc ccg gtt ttc gtt gaattccgat g                          994
Ser Asn Ile Pro Val Phe Val
        320
 

<210> 36
<211> 324
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in E. coli

<400> 36
Met Ser Thr Ala Thr Ala Ser Pro Ala Val Lys Leu Asn Ser Gly Tyr
 1               5                  10                  15      
Glu Ile Pro Leu Val Gly Phe Gly Cys Trp Lys Leu Thr Asn Asp Val
            20                  25                  30          
Ala Ser Asp Gln Ile Tyr Arg Ala Ile Lys Ser Gly Tyr Arg Leu Phe
        35                  40                  45              
Asp Gly Ala Glu Asp Tyr Ala Asn Glu Gln Glu Val Gly Glu Gly Ile
    50                  55                  60                  
Lys Arg Ala Ile Lys Glu Gly Ile Val Lys Arg Glu Glu Leu Phe Ile
65                  70                  75                  80  
Thr Ser Lys Leu Trp Asn Ser Phe His Asp Lys Lys Asn Val Glu Val
                85                  90                  95      
Ala Leu Met Lys Thr Leu Ser Asp Leu Asn Leu Asp Tyr Val Asp Leu
            100                 105                 110         
Phe Tyr Ile His Phe Pro Ile Ala Gln Lys Pro Val Pro Ile Glu Lys
        115                 120                 125             
Lys Tyr Pro Pro Gly Phe Tyr Cys Gly Asp Gly Asp Lys Trp Ser Ile
    130                 135                 140                 
Glu Glu Val Pro Leu Leu Asp Thr Trp Arg Ala Leu Glu Lys Leu Val
145                 150                 155                 160 
Asp Gln Gly Leu Ala Lys Ser Ile Gly Ile Ser Asn Phe Ser Ala Gln
                165                 170                 175     
Leu Ile Tyr Asp Leu Ile Arg Gly Cys Thr Ile Lys Pro Val Ala Leu
            180                 185                 190         
Gln Ile Glu His His Pro Tyr Leu Thr Gln Pro Lys Leu Val Glu Tyr
        195                 200                 205             
Val Gln Leu His Asp Ile Gln Ile Thr Gly Tyr Ser Ser Phe Gly Pro
    210                 215                 220                 
Gln Ser Phe Leu Glu Met Asp Leu Lys Arg Ala Leu Asp Thr Pro Val
225                 230                 235                 240 
Leu Leu Glu Glu Pro Thr Val Lys Ser Ile Ala Asp Lys His Gly Lys
                245                 250                 255     
Ser Pro Ala Gln Val Leu Leu Arg Tyr Gln Thr Gln Arg Gly Ile Ala
            260                 265                 270         
Val Ile Pro Arg Ser Asn Ser Pro Asp Arg Met Ala Gln Asn Leu Ser
        275                 280                 285             
Val Ile Asp Phe Glu Leu Thr Gln Asp Asp Leu Gln Ala Ile Ala Glu
    290                 295                 300                 
Leu Asp Cys Asn Leu Arg Phe Asn Glu Pro Trp Asp Phe Ser Asn Ile
305                 310                 315                 320 
Pro Val Phe Val
                


<210> 37
<211> 1000
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in E. coli

<220> 
<221> CDS            
<222> (15)...(986)

<400> 37
gaatactcca tatg atg tct acc gcg act gca tct ccg gct gtt aaa ctg   50
                Met Ser Thr Ala Thr Ala Ser Pro Ala Val Lys Leu
                 1               5                   10
 
aac tct ggt tac gaa atc ccg ctg gtt ggt ttc ggt tgc tgg aaa ctg   98
Asn Ser Gly Tyr Glu Ile Pro Leu Val Gly Phe Gly Cys Trp Lys Leu
         15                  20                  25
 
acc aac gac gtt gct tct gac cag atc tac cgt gcg att aaa tct ggc   146
Thr Asn Asp Val Ala Ser Asp Gln Ile Tyr Arg Ala Ile Lys Ser Gly
     30                  35                  40
 
tac cgt ctg ttc gat ggt gcg gag gac tat gcg aac gaa cag gaa gtt   194
Tyr Arg Leu Phe Asp Gly Ala Glu Asp Tyr Ala Asn Glu Gln Glu Val
 45                  50                  55                  60
 
ggt gaa ggt atc aaa cgt gct atc aaa gaa ggt atc gtt aaa cgt gaa   242
Gly Glu Gly Ile Lys Arg Ala Ile Lys Glu Gly Ile Val Lys Arg Glu
                 65                  70                  75
 
gaa ctg ttc atc acc tct aaa ctg tgg aac tct ttc cat gac aaa aag   290
Glu Leu Phe Ile Thr Ser Lys Leu Trp Asn Ser Phe His Asp Lys Lys
             80                  85                  90
 
aac gtt gaa gtt gct ctg atg aaa acc ctg tct gac ctg aac ctg gac   338
Asn Val Glu Val Ala Leu Met Lys Thr Leu Ser Asp Leu Asn Leu Asp
         95                 100                 105
 
tac gtt gac ctg ttc tac atc cac ttc cca atc gcg cag aaa ccg gtg   386
Tyr Val Asp Leu Phe Tyr Ile His Phe Pro Ile Ala Gln Lys Pro Val
    110                 115                 120
 
ccg atc gaa aag aag tac ccg cca ggt ttc tac tgt ggt gac ggt gac   434
Pro Ile Glu Lys Lys Tyr Pro Pro Gly Phe Tyr Cys Gly Asp Gly Asp
125                 130                 135                 140
 
aaa tgg tct atc gaa gaa gtt ccg ctg ctg gac act tgg cgt gcg ctc   482
Lys Trp Ser Ile Glu Glu Val Pro Leu Leu Asp Thr Trp Arg Ala Leu
                145                 150                 155
 
gaa aag ctg gtt gat cag ggt ctg gct aaa tct atc ggt atc tct aac   530
Glu Lys Leu Val Asp Gln Gly Leu Ala Lys Ser Ile Gly Ile Ser Asn
            160                 165                 170
 
ttc tct gct cag ctg atc tac gac ctg atc cgt ggc tgc acc atc aaa   578
Phe Ser Ala Gln Leu Ile Tyr Asp Leu Ile Arg Gly Cys Thr Ile Lys
        175                 180                 185
 
ccg gtt gcg ctc cag atc gaa cac cac ccg tac ctg acc cag ccg aaa   626
Pro Val Ala Leu Gln Ile Glu His His Pro Tyr Leu Thr Gln Pro Lys
    190                 195                 200
 
ctg gtt gaa tac gtt caa ctg cat gac atc cag atc acc ggt tac tct   674
Leu Val Glu Tyr Val Gln Leu His Asp Ile Gln Ile Thr Gly Tyr Ser
205                 210                 215                 220
 
tct ttc ggt ccg cag tct ttc ttg gaa atg gac ctg aaa cgt gcg ttg   722
Ser Phe Gly Pro Gln Ser Phe Leu Glu Met Asp Leu Lys Arg Ala Leu
                225                 230                 235
 
gac acc cca gtt ctg ctc gaa gaa ccg acc gtt aaa tct att gcg gac   770
Asp Thr Pro Val Leu Leu Glu Glu Pro Thr Val Lys Ser Ile Ala Asp
            240                 245                 250
 
aaa cac ggt aaa tct ccg gct cag gtt ctc ttg cgt tat caa act caa   818
Lys His Gly Lys Ser Pro Ala Gln Val Leu Leu Arg Tyr Gln Thr Gln
        255                 260                 265
 
cgt ggt atc gct gtt atc ccg cgc agc aac tct ccg gac cgt atg gct   866
Arg Gly Ile Ala Val Ile Pro Arg Ser Asn Ser Pro Asp Arg Met Ala
    270                 275                 280
 
cag aac ctg tct gtt att gac ttc gaa ctg acc cag gac gac ctc cag   914
Gln Asn Leu Ser Val Ile Asp Phe Glu Leu Thr Gln Asp Asp Leu Gln
285                 290                 295                 300
 
gct atc gcg gaa ctg gac tgc aac ctg cgt ttc aac gaa ccg tgg gac   962
Ala Ile Ala Glu Leu Asp Cys Asn Leu Arg Phe Asn Glu Pro Trp Asp
                305                 310                 315
 
ttc tct aac atc ccg gtt ttc gtt actagtcagt gcct                   1000
Phe Ser Asn Ile Pro Val Phe Val
            320
 

<210> 38
<211> 324
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in E. coli

<400> 38
Met Ser Thr Ala Thr Ala Ser Pro Ala Val Lys Leu Asn Ser Gly Tyr
 1               5                  10                  15      
Glu Ile Pro Leu Val Gly Phe Gly Cys Trp Lys Leu Thr Asn Asp Val
            20                  25                  30          
Ala Ser Asp Gln Ile Tyr Arg Ala Ile Lys Ser Gly Tyr Arg Leu Phe
        35                  40                  45              
Asp Gly Ala Glu Asp Tyr Ala Asn Glu Gln Glu Val Gly Glu Gly Ile
    50                  55                  60                  
Lys Arg Ala Ile Lys Glu Gly Ile Val Lys Arg Glu Glu Leu Phe Ile
65                  70                  75                  80  
Thr Ser Lys Leu Trp Asn Ser Phe His Asp Lys Lys Asn Val Glu Val
                85                  90                  95      
Ala Leu Met Lys Thr Leu Ser Asp Leu Asn Leu Asp Tyr Val Asp Leu
            100                 105                 110         
Phe Tyr Ile His Phe Pro Ile Ala Gln Lys Pro Val Pro Ile Glu Lys
        115                 120                 125             
Lys Tyr Pro Pro Gly Phe Tyr Cys Gly Asp Gly Asp Lys Trp Ser Ile
    130                 135                 140                 
Glu Glu Val Pro Leu Leu Asp Thr Trp Arg Ala Leu Glu Lys Leu Val
145                 150                 155                 160 
Asp Gln Gly Leu Ala Lys Ser Ile Gly Ile Ser Asn Phe Ser Ala Gln
                165                 170                 175     
Leu Ile Tyr Asp Leu Ile Arg Gly Cys Thr Ile Lys Pro Val Ala Leu
            180                 185                 190         
Gln Ile Glu His His Pro Tyr Leu Thr Gln Pro Lys Leu Val Glu Tyr
        195                 200                 205             
Val Gln Leu His Asp Ile Gln Ile Thr Gly Tyr Ser Ser Phe Gly Pro
    210                 215                 220                 
Gln Ser Phe Leu Glu Met Asp Leu Lys Arg Ala Leu Asp Thr Pro Val
225                 230                 235                 240 
Leu Leu Glu Glu Pro Thr Val Lys Ser Ile Ala Asp Lys His Gly Lys
                245                 250                 255     
Ser Pro Ala Gln Val Leu Leu Arg Tyr Gln Thr Gln Arg Gly Ile Ala
            260                 265                 270         
Val Ile Pro Arg Ser Asn Ser Pro Asp Arg Met Ala Gln Asn Leu Ser
        275                 280                 285             
Val Ile Asp Phe Glu Leu Thr Gln Asp Asp Leu Gln Ala Ile Ala Glu
    290                 295                 300                 
Leu Asp Cys Asn Leu Arg Phe Asn Glu Pro Trp Asp Phe Ser Asn Ile
305                 310                 315                 320 
Pro Val Phe Val
                


<210> 39
<211> 972
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in P. pastoris

<220> 
<221> CDS            
<222> (1)...(972)

<400> 39
atg tcc act gct act gct tca cct gct gtt aaa tta aat tct ggt tat   48
Met Ser Thr Ala Thr Ala Ser Pro Ala Val Lys Leu Asn Ser Gly Tyr
 1               5                   10                  15
 
gaa att cca ttg gtt ggt ttt ggt tgt tgg aaa ttg act aat gat gtt   96
Glu Ile Pro Leu Val Gly Phe Gly Cys Trp Lys Leu Thr Asn Asp Val
             20                  25                  30
 
gct tct gat caa att tat aga gca att aag tct gga tat aga ttg ttt   144
Ala Ser Asp Gln Ile Tyr Arg Ala Ile Lys Ser Gly Tyr Arg Leu Phe
         35                  40                  45
 
gat gga gct gaa gat tat gct aat gaa caa gaa gtt gga gag gga att   192
Asp Gly Ala Glu Asp Tyr Ala Asn Glu Gln Glu Val Gly Glu Gly Ile
     50                  55                  60
 
aaa aga gct att aaa gaa gga att gtt aaa aga gag gaa ttg ttt att   240
Lys Arg Ala Ile Lys Glu Gly Ile Val Lys Arg Glu Glu Leu Phe Ile
 65                  70                  75                  80
 
act tct aaa ttg tgg aac agc ttt cat gat aaa aag aac gtg gaa gtt   288
Thr Ser Lys Leu Trp Asn Ser Phe His Asp Lys Lys Asn Val Glu Val
                 85                  90                  95
 
gca ttg atg aaa act tta tct gat tta aat ttg gat tat gtt gat ttg   336
Ala Leu Met Lys Thr Leu Ser Asp Leu Asn Leu Asp Tyr Val Asp Leu
            100                 105                 110
 
ttt tat att cat ttt cca att gca caa aag cca gtt cca atc gag aaa   384
Phe Tyr Ile His Phe Pro Ile Ala Gln Lys Pro Val Pro Ile Glu Lys
        115                 120                 125
 
aag tac cct cct gga ttt tat tgt ggt gat gga gat aag tgg tct att   432
Lys Tyr Pro Pro Gly Phe Tyr Cys Gly Asp Gly Asp Lys Trp Ser Ile
    130                 135                 140
 
gaa gaa gtg cca ttg ttg gat act tgg aga gct tta gaa aaa ttg gtt   480
Glu Glu Val Pro Leu Leu Asp Thr Trp Arg Ala Leu Glu Lys Leu Val
145                 150                 155                 160
 
gat caa gga ttg gct aaa tct att gga att tct aat ttt tct gct caa   528
Asp Gln Gly Leu Ala Lys Ser Ile Gly Ile Ser Asn Phe Ser Ala Gln
                165                 170                 175
 
ttg att tat gat ttg att aga gga tgt act att aaa ccc gtt gct ttg   576
Leu Ile Tyr Asp Leu Ile Arg Gly Cys Thr Ile Lys Pro Val Ala Leu
            180                 185                 190
 
caa att gaa cat cat cca tat ttg act cag cca aaa tta gtt gaa tat   624
Gln Ile Glu His His Pro Tyr Leu Thr Gln Pro Lys Leu Val Glu Tyr
        195                 200                 205
 
gtg caa tta cat gac att caa att act gga tat tct tct ttc gga cca   672
Val Gln Leu His Asp Ile Gln Ile Thr Gly Tyr Ser Ser Phe Gly Pro
    210                 215                 220
 
caa tct ttt ctt gaa atg gat tta aaa aga gct ttg gat act cct gtt   720
Gln Ser Phe Leu Glu Met Asp Leu Lys Arg Ala Leu Asp Thr Pro Val
225                 230                 235                 240
 
ttg ctt gaa gaa cca act gtt aaa tct att gct gat aaa cat gga aaa   768
Leu Leu Glu Glu Pro Thr Val Lys Ser Ile Ala Asp Lys His Gly Lys
                245                 250                 255
 
tca cca gca caa gtt tta ctt aga tat caa act caa agg gga att gct   816
Ser Pro Ala Gln Val Leu Leu Arg Tyr Gln Thr Gln Arg Gly Ile Ala
            260                 265                 270
 
gtt ata cca cgt tct aat tct cca gat aga atg gct caa aat ttg tct   864
Val Ile Pro Arg Ser Asn Ser Pro Asp Arg Met Ala Gln Asn Leu Ser
        275                 280                 285
 
gtt att gat ttc gaa ttg act cag gat gat ttg cag gct atc gct gaa   912
Val Ile Asp Phe Glu Leu Thr Gln Asp Asp Leu Gln Ala Ile Ala Glu
    290                 295                 300
 
ttg gat tgt aat ttg aga ttt aat gaa cca tgg gat ttt tct aac att   960
Leu Asp Cys Asn Leu Arg Phe Asn Glu Pro Trp Asp Phe Ser Asn Ile
305                 310                 315                 320
 
cca gtt ttt gtt                                                   972
Pro Val Phe Val

 

<210> 40
<211> 324
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in P. pastoris

<400> 40
Met Ser Thr Ala Thr Ala Ser Pro Ala Val Lys Leu Asn Ser Gly Tyr
 1               5                  10                  15      
Glu Ile Pro Leu Val Gly Phe Gly Cys Trp Lys Leu Thr Asn Asp Val
            20                  25                  30          
Ala Ser Asp Gln Ile Tyr Arg Ala Ile Lys Ser Gly Tyr Arg Leu Phe
        35                  40                  45              
Asp Gly Ala Glu Asp Tyr Ala Asn Glu Gln Glu Val Gly Glu Gly Ile
    50                  55                  60                  
Lys Arg Ala Ile Lys Glu Gly Ile Val Lys Arg Glu Glu Leu Phe Ile
65                  70                  75                  80  
Thr Ser Lys Leu Trp Asn Ser Phe His Asp Lys Lys Asn Val Glu Val
                85                  90                  95      
Ala Leu Met Lys Thr Leu Ser Asp Leu Asn Leu Asp Tyr Val Asp Leu
            100                 105                 110         
Phe Tyr Ile His Phe Pro Ile Ala Gln Lys Pro Val Pro Ile Glu Lys
        115                 120                 125             
Lys Tyr Pro Pro Gly Phe Tyr Cys Gly Asp Gly Asp Lys Trp Ser Ile
    130                 135                 140                 
Glu Glu Val Pro Leu Leu Asp Thr Trp Arg Ala Leu Glu Lys Leu Val
145                 150                 155                 160 
Asp Gln Gly Leu Ala Lys Ser Ile Gly Ile Ser Asn Phe Ser Ala Gln
                165                 170                 175     
Leu Ile Tyr Asp Leu Ile Arg Gly Cys Thr Ile Lys Pro Val Ala Leu
            180                 185                 190         
Gln Ile Glu His His Pro Tyr Leu Thr Gln Pro Lys Leu Val Glu Tyr
        195                 200                 205             
Val Gln Leu His Asp Ile Gln Ile Thr Gly Tyr Ser Ser Phe Gly Pro
    210                 215                 220                 
Gln Ser Phe Leu Glu Met Asp Leu Lys Arg Ala Leu Asp Thr Pro Val
225                 230                 235                 240 
Leu Leu Glu Glu Pro Thr Val Lys Ser Ile Ala Asp Lys His Gly Lys
                245                 250                 255     
Ser Pro Ala Gln Val Leu Leu Arg Tyr Gln Thr Gln Arg Gly Ile Ala
            260                 265                 270         
Val Ile Pro Arg Ser Asn Ser Pro Asp Arg Met Ala Gln Asn Leu Ser
        275                 280                 285             
Val Ile Asp Phe Glu Leu Thr Gln Asp Asp Leu Gln Ala Ile Ala Glu
    290                 295                 300                 
Leu Asp Cys Asn Leu Arg Phe Asn Glu Pro Trp Asp Phe Ser Asn Ile
305                 310                 315                 320 
Pro Val Phe Val
                


<210> 41
<211> 994
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in P. pastoris

<220> 
<221> CDS            
<222> (12)...(983)

<400> 41
tactcaagct t atg tcc act gct act gct tca cct gct gtt aaa tta aat  50
             Met Ser Thr Ala Thr Ala Ser Pro Ala Val Lys Leu Asn
              1               5                   10
 
tct ggt tat gaa att cca ttg gtt ggt ttt ggt tgt tgg aaa ttg act   98
Ser Gly Tyr Glu Ile Pro Leu Val Gly Phe Gly Cys Trp Lys Leu Thr
     15                  20                  25
 
aat gat gtt gct tct gat caa att tat aga gca att aag tct gga tat   146
Asn Asp Val Ala Ser Asp Gln Ile Tyr Arg Ala Ile Lys Ser Gly Tyr
 30                  35                  40                  45
 
aga ttg ttt gat gga gct gaa gat tat gct aat gaa caa gaa gtt gga   194
Arg Leu Phe Asp Gly Ala Glu Asp Tyr Ala Asn Glu Gln Glu Val Gly
                 50                  55                  60
 
gag gga att aaa aga gct att aaa gaa gga att gtt aaa aga gag gaa   242
Glu Gly Ile Lys Arg Ala Ile Lys Glu Gly Ile Val Lys Arg Glu Glu
             65                  70                  75
 
ttg ttt att act tct aaa ttg tgg aac agc ttt cat gat aaa aag aac   290
Leu Phe Ile Thr Ser Lys Leu Trp Asn Ser Phe His Asp Lys Lys Asn
         80                  85                  90
 
gtg gaa gtt gca ttg atg aaa act tta tct gat tta aat ttg gat tat   338
Val Glu Val Ala Leu Met Lys Thr Leu Ser Asp Leu Asn Leu Asp Tyr
     95                 100                 105
 
gtt gat ttg ttt tat att cat ttt cca att gca caa aag cca gtt cca   386
Val Asp Leu Phe Tyr Ile His Phe Pro Ile Ala Gln Lys Pro Val Pro
110                 115                 120                 125
 
atc gag aaa aag tac cct cct gga ttt tat tgt ggt gat gga gat aag   434
Ile Glu Lys Lys Tyr Pro Pro Gly Phe Tyr Cys Gly Asp Gly Asp Lys
                130                 135                 140
 
tgg tct att gaa gaa gtg cca ttg ttg gat act tgg aga gct tta gaa   482
Trp Ser Ile Glu Glu Val Pro Leu Leu Asp Thr Trp Arg Ala Leu Glu
            145                 150                 155
 
aaa ttg gtt gat caa gga ttg gct aaa tct att gga att tct aat ttt   530
Lys Leu Val Asp Gln Gly Leu Ala Lys Ser Ile Gly Ile Ser Asn Phe
        160                 165                 170
 
tct gct caa ttg att tat gat ttg att aga gga tgt act att aaa ccc   578
Ser Ala Gln Leu Ile Tyr Asp Leu Ile Arg Gly Cys Thr Ile Lys Pro
    175                 180                 185
 
gtt gct ttg caa att gaa cat cat cca tat ttg act cag cca aaa tta   626
Val Ala Leu Gln Ile Glu His His Pro Tyr Leu Thr Gln Pro Lys Leu
190                 195                 200                 205
 
gtt gaa tat gtg caa tta cat gac att caa att act gga tat tct tct   674
Val Glu Tyr Val Gln Leu His Asp Ile Gln Ile Thr Gly Tyr Ser Ser
                210                 215                 220
 
ttc gga cca caa tct ttt ctt gaa atg gat tta aaa aga gct ttg gat   722
Phe Gly Pro Gln Ser Phe Leu Glu Met Asp Leu Lys Arg Ala Leu Asp
            225                 230                 235
 
act cct gtt ttg ctt gaa gaa cca act gtt aaa tct att gct gat aaa   770
Thr Pro Val Leu Leu Glu Glu Pro Thr Val Lys Ser Ile Ala Asp Lys
        240                 245                 250
 
cat gga aaa tca cca gca caa gtt tta ctt aga tat caa act caa agg   818
His Gly Lys Ser Pro Ala Gln Val Leu Leu Arg Tyr Gln Thr Gln Arg
    255                 260                 265
 
gga att gct gtt ata cca cgt tct aat tct cca gat aga atg gct caa   866
Gly Ile Ala Val Ile Pro Arg Ser Asn Ser Pro Asp Arg Met Ala Gln
270                 275                 280                 285
 
aat ttg tct gtt att gat ttc gaa ttg act cag gat gat ttg cag gct   914
Asn Leu Ser Val Ile Asp Phe Glu Leu Thr Gln Asp Asp Leu Gln Ala
                290                 295                 300
 
atc gct gaa ttg gat tgt aat ttg aga ttt aat gaa cca tgg gat ttt   962
Ile Ala Glu Leu Asp Cys Asn Leu Arg Phe Asn Glu Pro Trp Asp Phe
            305                 310                 315
 
tct aac att cca gtt ttt gtt gaattccgat g                          994
Ser Asn Ile Pro Val Phe Val
        320
 

<210> 42
<211> 324
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in P. pastoris

<400> 42
Met Ser Thr Ala Thr Ala Ser Pro Ala Val Lys Leu Asn Ser Gly Tyr
 1               5                  10                  15      
Glu Ile Pro Leu Val Gly Phe Gly Cys Trp Lys Leu Thr Asn Asp Val
            20                  25                  30          
Ala Ser Asp Gln Ile Tyr Arg Ala Ile Lys Ser Gly Tyr Arg Leu Phe
        35                  40                  45              
Asp Gly Ala Glu Asp Tyr Ala Asn Glu Gln Glu Val Gly Glu Gly Ile
    50                  55                  60                  
Lys Arg Ala Ile Lys Glu Gly Ile Val Lys Arg Glu Glu Leu Phe Ile
65                  70                  75                  80  
Thr Ser Lys Leu Trp Asn Ser Phe His Asp Lys Lys Asn Val Glu Val
                85                  90                  95      
Ala Leu Met Lys Thr Leu Ser Asp Leu Asn Leu Asp Tyr Val Asp Leu
            100                 105                 110         
Phe Tyr Ile His Phe Pro Ile Ala Gln Lys Pro Val Pro Ile Glu Lys
        115                 120                 125             
Lys Tyr Pro Pro Gly Phe Tyr Cys Gly Asp Gly Asp Lys Trp Ser Ile
    130                 135                 140                 
Glu Glu Val Pro Leu Leu Asp Thr Trp Arg Ala Leu Glu Lys Leu Val
145                 150                 155                 160 
Asp Gln Gly Leu Ala Lys Ser Ile Gly Ile Ser Asn Phe Ser Ala Gln
                165                 170                 175     
Leu Ile Tyr Asp Leu Ile Arg Gly Cys Thr Ile Lys Pro Val Ala Leu
            180                 185                 190         
Gln Ile Glu His His Pro Tyr Leu Thr Gln Pro Lys Leu Val Glu Tyr
        195                 200                 205             
Val Gln Leu His Asp Ile Gln Ile Thr Gly Tyr Ser Ser Phe Gly Pro
    210                 215                 220                 
Gln Ser Phe Leu Glu Met Asp Leu Lys Arg Ala Leu Asp Thr Pro Val
225                 230                 235                 240 
Leu Leu Glu Glu Pro Thr Val Lys Ser Ile Ala Asp Lys His Gly Lys
                245                 250                 255     
Ser Pro Ala Gln Val Leu Leu Arg Tyr Gln Thr Gln Arg Gly Ile Ala
            260                 265                 270         
Val Ile Pro Arg Ser Asn Ser Pro Asp Arg Met Ala Gln Asn Leu Ser
        275                 280                 285             
Val Ile Asp Phe Glu Leu Thr Gln Asp Asp Leu Gln Ala Ile Ala Glu
    290                 295                 300                 
Leu Asp Cys Asn Leu Arg Phe Asn Glu Pro Trp Asp Phe Ser Asn Ile
305                 310                 315                 320 
Pro Val Phe Val
                


<210> 43
<211> 1000
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in P. pastoris

<220> 
<221> CDS            
<222> (15)...(986)

<400> 43
gaatactcca tatg atg tcc act gct act gct tca cct gct gtt aaa tta   50
                Met Ser Thr Ala Thr Ala Ser Pro Ala Val Lys Leu
                 1               5                   10
 
aat tct ggt tat gaa att cca ttg gtt ggt ttt ggt tgt tgg aaa ttg   98
Asn Ser Gly Tyr Glu Ile Pro Leu Val Gly Phe Gly Cys Trp Lys Leu
         15                  20                  25
 
act aat gat gtt gct tct gat caa att tat aga gca att aag tct gga   146
Thr Asn Asp Val Ala Ser Asp Gln Ile Tyr Arg Ala Ile Lys Ser Gly
     30                  35                  40
 
tat aga ttg ttt gat gga gct gaa gat tat gct aat gaa caa gaa gtt   194
Tyr Arg Leu Phe Asp Gly Ala Glu Asp Tyr Ala Asn Glu Gln Glu Val
 45                  50                  55                  60
 
gga gag gga att aaa aga gct att aaa gaa gga att gtt aaa aga gag   242
Gly Glu Gly Ile Lys Arg Ala Ile Lys Glu Gly Ile Val Lys Arg Glu
                 65                  70                  75
 
gaa ttg ttt att act tct aaa ttg tgg aac agc ttt cat gat aaa aag   290
Glu Leu Phe Ile Thr Ser Lys Leu Trp Asn Ser Phe His Asp Lys Lys
             80                  85                  90
 
aac gtg gaa gtt gca ttg atg aaa act tta tct gat tta aat ttg gat   338
Asn Val Glu Val Ala Leu Met Lys Thr Leu Ser Asp Leu Asn Leu Asp
         95                 100                 105
 
tat gtt gat ttg ttt tat att cat ttt cca att gca caa aag cca gtt   386
Tyr Val Asp Leu Phe Tyr Ile His Phe Pro Ile Ala Gln Lys Pro Val
    110                 115                 120
 
cca atc gag aaa aag tac cct cct gga ttt tat tgt ggt gat gga gat   434
Pro Ile Glu Lys Lys Tyr Pro Pro Gly Phe Tyr Cys Gly Asp Gly Asp
125                 130                 135                 140
 
aag tgg tct att gaa gaa gtg cca ttg ttg gat act tgg aga gct tta   482
Lys Trp Ser Ile Glu Glu Val Pro Leu Leu Asp Thr Trp Arg Ala Leu
                145                 150                 155
 
gaa aaa ttg gtt gat caa gga ttg gct aaa tct att gga att tct aat   530
Glu Lys Leu Val Asp Gln Gly Leu Ala Lys Ser Ile Gly Ile Ser Asn
            160                 165                 170
 
ttt tct gct caa ttg att tat gat ttg att aga gga tgt act att aaa   578
Phe Ser Ala Gln Leu Ile Tyr Asp Leu Ile Arg Gly Cys Thr Ile Lys
        175                 180                 185
 
ccc gtt gct ttg caa att gaa cat cat cca tat ttg act cag cca aaa   626
Pro Val Ala Leu Gln Ile Glu His His Pro Tyr Leu Thr Gln Pro Lys
    190                 195                 200
 
tta gtt gaa tat gtg caa tta cat gac att caa att act gga tat tct   674
Leu Val Glu Tyr Val Gln Leu His Asp Ile Gln Ile Thr Gly Tyr Ser
205                 210                 215                 220
 
tct ttc gga cca caa tct ttt ctt gaa atg gat tta aaa aga gct ttg   722
Ser Phe Gly Pro Gln Ser Phe Leu Glu Met Asp Leu Lys Arg Ala Leu
                225                 230                 235
 
gat act cct gtt ttg ctt gaa gaa cca act gtt aaa tct att gct gat   770
Asp Thr Pro Val Leu Leu Glu Glu Pro Thr Val Lys Ser Ile Ala Asp
            240                 245                 250
 
aaa cat gga aaa tca cca gca caa gtt tta ctt aga tat caa act caa   818
Lys His Gly Lys Ser Pro Ala Gln Val Leu Leu Arg Tyr Gln Thr Gln
        255                 260                 265
 
agg gga att gct gtt ata cca cgt tct aat tct cca gat aga atg gct   866
Arg Gly Ile Ala Val Ile Pro Arg Ser Asn Ser Pro Asp Arg Met Ala
    270                 275                 280
 
caa aat ttg tct gtt att gat ttc gaa ttg act cag gat gat ttg cag   914
Gln Asn Leu Ser Val Ile Asp Phe Glu Leu Thr Gln Asp Asp Leu Gln
285                 290                 295                 300
 
gct atc gct gaa ttg gat tgt aat ttg aga ttt aat gaa cca tgg gat   962
Ala Ile Ala Glu Leu Asp Cys Asn Leu Arg Phe Asn Glu Pro Trp Asp
                305                 310                 315
 
ttt tct aac att cca gtt ttt gtt actagtcagt gcct                   1000
Phe Ser Asn Ile Pro Val Phe Val
            320
 

<210> 44
<211> 324
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in P. pastoris

<400> 44
Met Ser Thr Ala Thr Ala Ser Pro Ala Val Lys Leu Asn Ser Gly Tyr
 1               5                  10                  15      
Glu Ile Pro Leu Val Gly Phe Gly Cys Trp Lys Leu Thr Asn Asp Val
            20                  25                  30          
Ala Ser Asp Gln Ile Tyr Arg Ala Ile Lys Ser Gly Tyr Arg Leu Phe
        35                  40                  45              
Asp Gly Ala Glu Asp Tyr Ala Asn Glu Gln Glu Val Gly Glu Gly Ile
    50                  55                  60                  
Lys Arg Ala Ile Lys Glu Gly Ile Val Lys Arg Glu Glu Leu Phe Ile
65                  70                  75                  80  
Thr Ser Lys Leu Trp Asn Ser Phe His Asp Lys Lys Asn Val Glu Val
                85                  90                  95      
Ala Leu Met Lys Thr Leu Ser Asp Leu Asn Leu Asp Tyr Val Asp Leu
            100                 105                 110         
Phe Tyr Ile His Phe Pro Ile Ala Gln Lys Pro Val Pro Ile Glu Lys
        115                 120                 125             
Lys Tyr Pro Pro Gly Phe Tyr Cys Gly Asp Gly Asp Lys Trp Ser Ile
    130                 135                 140                 
Glu Glu Val Pro Leu Leu Asp Thr Trp Arg Ala Leu Glu Lys Leu Val
145                 150                 155                 160 
Asp Gln Gly Leu Ala Lys Ser Ile Gly Ile Ser Asn Phe Ser Ala Gln
                165                 170                 175     
Leu Ile Tyr Asp Leu Ile Arg Gly Cys Thr Ile Lys Pro Val Ala Leu
            180                 185                 190         
Gln Ile Glu His His Pro Tyr Leu Thr Gln Pro Lys Leu Val Glu Tyr
        195                 200                 205             
Val Gln Leu His Asp Ile Gln Ile Thr Gly Tyr Ser Ser Phe Gly Pro
    210                 215                 220                 
Gln Ser Phe Leu Glu Met Asp Leu Lys Arg Ala Leu Asp Thr Pro Val
225                 230                 235                 240 
Leu Leu Glu Glu Pro Thr Val Lys Ser Ile Ala Asp Lys His Gly Lys
                245                 250                 255     
Ser Pro Ala Gln Val Leu Leu Arg Tyr Gln Thr Gln Arg Gly Ile Ala
            260                 265                 270         
Val Ile Pro Arg Ser Asn Ser Pro Asp Arg Met Ala Gln Asn Leu Ser
        275                 280                 285             
Val Ile Asp Phe Glu Leu Thr Gln Asp Asp Leu Gln Ala Ile Ala Glu
    290                 295                 300                 
Leu Asp Cys Asn Leu Arg Phe Asn Glu Pro Trp Asp Phe Ser Asn Ile
305                 310                 315                 320 
Pro Val Phe Val
                


<210> 45
<211> 972
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in K. lactis

<220> 
<221> CDS            
<222> (1)...(972)

<400> 45
atg tct act gct act gct tca cca gct gtt aaa tta aat tct ggt tat   48
Met Ser Thr Ala Thr Ala Ser Pro Ala Val Lys Leu Asn Ser Gly Tyr
 1               5                   10                  15
 
gaa att cca ttg gtt ggt ttc ggt tgt tgg aaa ttg act aat gat gtt   96
Glu Ile Pro Leu Val Gly Phe Gly Cys Trp Lys Leu Thr Asn Asp Val
             20                  25                  30
 
gct tct gat caa att tat aga gca att aaa tct ggt tat aga ttg ttc   144
Ala Ser Asp Gln Ile Tyr Arg Ala Ile Lys Ser Gly Tyr Arg Leu Phe
         35                  40                  45
 
gat ggt gct gaa gat tat gct aat gaa caa gaa gtt ggt gag gga att   192
Asp Gly Ala Glu Asp Tyr Ala Asn Glu Gln Glu Val Gly Glu Gly Ile
     50                  55                  60
 
aaa aga gct att aaa gaa gga att gtt aaa aga gaa gaa ttg ttc att   240
Lys Arg Ala Ile Lys Glu Gly Ile Val Lys Arg Glu Glu Leu Phe Ile
 65                  70                  75                  80
 
act tct aaa ttg tgg aac tct ttc cac gac aaa aaa aat gtt gaa gtt   288
Thr Ser Lys Leu Trp Asn Ser Phe His Asp Lys Lys Asn Val Glu Val
                 85                  90                  95
 
gct ttg atg aaa aca ttg tct gat tta aat ttg gat tat gtt gat ttg   336
Ala Leu Met Lys Thr Leu Ser Asp Leu Asn Leu Asp Tyr Val Asp Leu
            100                 105                 110
 
ttc tat att cat ttt cca att gct caa aaa cca gtt cca att gaa aaa   384
Phe Tyr Ile His Phe Pro Ile Ala Gln Lys Pro Val Pro Ile Glu Lys
        115                 120                 125
 
aaa tat cca cca ggt ttc tat tgt ggt gat ggt gat aag tgg tct att   432
Lys Tyr Pro Pro Gly Phe Tyr Cys Gly Asp Gly Asp Lys Trp Ser Ile
    130                 135                 140
 
gaa gaa gtt cca ttg ttg gat act tgg aga gct ttg gag aag ctc gtt   480
Glu Glu Val Pro Leu Leu Asp Thr Trp Arg Ala Leu Glu Lys Leu Val
145                 150                 155                 160
 
gat caa ggt ttg gct aaa tct att gga atc tct aat ttc tct gct caa   528
Asp Gln Gly Leu Ala Lys Ser Ile Gly Ile Ser Asn Phe Ser Ala Gln
                165                 170                 175
 
ttg att tat gat ttg att aga ggt tgt act att aaa cca gtt gct ctt   576
Leu Ile Tyr Asp Leu Ile Arg Gly Cys Thr Ile Lys Pro Val Ala Leu
            180                 185                 190
 
cag att gaa cat cat cca tat tta act caa cca aaa tta gta gaa tat   624
Gln Ile Glu His His Pro Tyr Leu Thr Gln Pro Lys Leu Val Glu Tyr
        195                 200                 205
 
gtt caa ttg cat gac atc cag att act ggt tat tct tct ttc ggt cca   672
Val Gln Leu His Asp Ile Gln Ile Thr Gly Tyr Ser Ser Phe Gly Pro
    210                 215                 220
 
caa tct ttc ttg gaa atg gat tta aaa aga gct ctc gat act cca gtt   720
Gln Ser Phe Leu Glu Met Asp Leu Lys Arg Ala Leu Asp Thr Pro Val
225                 230                 235                 240
 
ttg ttg gaa gaa cca act gtt aag agc att gct gac aaa cat ggt aag   768
Leu Leu Glu Glu Pro Thr Val Lys Ser Ile Ala Asp Lys His Gly Lys
                245                 250                 255
 
tca ccg gca caa gtt ttg tta aga tat caa act caa aga ggt ata gct   816
Ser Pro Ala Gln Val Leu Leu Arg Tyr Gln Thr Gln Arg Gly Ile Ala
            260                 265                 270
 
gtt att cca agg tct aat tct cct gat aga atg gct caa aat ttg tct   864
Val Ile Pro Arg Ser Asn Ser Pro Asp Arg Met Ala Gln Asn Leu Ser
        275                 280                 285
 
gtt att gat ttc gaa ttg act caa gat gat ttg caa gct atc gcc gaa   912
Val Ile Asp Phe Glu Leu Thr Gln Asp Asp Leu Gln Ala Ile Ala Glu
    290                 295                 300
 
ttg gat tgt aat ttg aga ttc aat gaa cca tgg gat ttc tct aat att   960
Leu Asp Cys Asn Leu Arg Phe Asn Glu Pro Trp Asp Phe Ser Asn Ile
305                 310                 315                 320
 
cca gtt ttc gtt                                                   972
Pro Val Phe Val

 

<210> 46
<211> 324
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in K. lactis

<400> 46
Met Ser Thr Ala Thr Ala Ser Pro Ala Val Lys Leu Asn Ser Gly Tyr
 1               5                  10                  15      
Glu Ile Pro Leu Val Gly Phe Gly Cys Trp Lys Leu Thr Asn Asp Val
            20                  25                  30          
Ala Ser Asp Gln Ile Tyr Arg Ala Ile Lys Ser Gly Tyr Arg Leu Phe
        35                  40                  45              
Asp Gly Ala Glu Asp Tyr Ala Asn Glu Gln Glu Val Gly Glu Gly Ile
    50                  55                  60                  
Lys Arg Ala Ile Lys Glu Gly Ile Val Lys Arg Glu Glu Leu Phe Ile
65                  70                  75                  80  
Thr Ser Lys Leu Trp Asn Ser Phe His Asp Lys Lys Asn Val Glu Val
                85                  90                  95      
Ala Leu Met Lys Thr Leu Ser Asp Leu Asn Leu Asp Tyr Val Asp Leu
            100                 105                 110         
Phe Tyr Ile His Phe Pro Ile Ala Gln Lys Pro Val Pro Ile Glu Lys
        115                 120                 125             
Lys Tyr Pro Pro Gly Phe Tyr Cys Gly Asp Gly Asp Lys Trp Ser Ile
    130                 135                 140                 
Glu Glu Val Pro Leu Leu Asp Thr Trp Arg Ala Leu Glu Lys Leu Val
145                 150                 155                 160 
Asp Gln Gly Leu Ala Lys Ser Ile Gly Ile Ser Asn Phe Ser Ala Gln
                165                 170                 175     
Leu Ile Tyr Asp Leu Ile Arg Gly Cys Thr Ile Lys Pro Val Ala Leu
            180                 185                 190         
Gln Ile Glu His His Pro Tyr Leu Thr Gln Pro Lys Leu Val Glu Tyr
        195                 200                 205             
Val Gln Leu His Asp Ile Gln Ile Thr Gly Tyr Ser Ser Phe Gly Pro
    210                 215                 220                 
Gln Ser Phe Leu Glu Met Asp Leu Lys Arg Ala Leu Asp Thr Pro Val
225                 230                 235                 240 
Leu Leu Glu Glu Pro Thr Val Lys Ser Ile Ala Asp Lys His Gly Lys
                245                 250                 255     
Ser Pro Ala Gln Val Leu Leu Arg Tyr Gln Thr Gln Arg Gly Ile Ala
            260                 265                 270         
Val Ile Pro Arg Ser Asn Ser Pro Asp Arg Met Ala Gln Asn Leu Ser
        275                 280                 285             
Val Ile Asp Phe Glu Leu Thr Gln Asp Asp Leu Gln Ala Ile Ala Glu
    290                 295                 300                 
Leu Asp Cys Asn Leu Arg Phe Asn Glu Pro Trp Asp Phe Ser Asn Ile
305                 310                 315                 320 
Pro Val Phe Val
                


<210> 47
<211> 972
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in Z. mobilis

<220> 
<221> CDS            
<222> (1)...(972)

<400> 47
atg tct acc gcc acc gct tct cct gcc gtt aaa ttg aat agc gga tat   48
Met Ser Thr Ala Thr Ala Ser Pro Ala Val Lys Leu Asn Ser Gly Tyr
 1               5                   10                  15
 
gaa att ccg ttg gtt ggt ttt ggt tgt tgg aaa ttg acg aat gat gtt   96
Glu Ile Pro Leu Val Gly Phe Gly Cys Trp Lys Leu Thr Asn Asp Val
             20                  25                  30
 
gcc tct gat cag att tat cgc gcc att aaa tct ggt tat cgt ttg ttt   144
Ala Ser Asp Gln Ile Tyr Arg Ala Ile Lys Ser Gly Tyr Arg Leu Phe
         35                  40                  45
 
gat ggt gcc gaa gat tat gct aat gaa cag gaa gtt ggt gaa ggg att   192
Asp Gly Ala Glu Asp Tyr Ala Asn Glu Gln Glu Val Gly Glu Gly Ile
     50                  55                  60
 
aaa cgt gcc atc aag gaa ggg att gtt aaa cgg gaa gaa ttg ttt att   240
Lys Arg Ala Ile Lys Glu Gly Ile Val Lys Arg Glu Glu Leu Phe Ile
 65                  70                  75                  80
 
acc tct aaa ttg tgg aat agc ttt cat gat aag aaa aat gtt gaa gtt   288
Thr Ser Lys Leu Trp Asn Ser Phe His Asp Lys Lys Asn Val Glu Val
                 85                  90                  95
 
gcc ctt atg aaa acc ttg tct gat ctg aat ttg gat tat gtt gat ttg   336
Ala Leu Met Lys Thr Leu Ser Asp Leu Asn Leu Asp Tyr Val Asp Leu
            100                 105                 110
 
ttc tat att cat ttt ccg att gcc cag aaa ccg gtc ccg att gaa aag   384
Phe Tyr Ile His Phe Pro Ile Ala Gln Lys Pro Val Pro Ile Glu Lys
        115                 120                 125
 
aag tat cca ccc ggc ttt tat tgt ggt gat ggt gat aaa tgg tct att   432
Lys Tyr Pro Pro Gly Phe Tyr Cys Gly Asp Gly Asp Lys Trp Ser Ile
    130                 135                 140
 
gaa gaa gtt ccg ttg ttg gat acc tgg aga gcc ctt gaa aaa ttg gtt   480
Glu Glu Val Pro Leu Leu Asp Thr Trp Arg Ala Leu Glu Lys Leu Val
145                 150                 155                 160
 
gat cag ggt ttg gct aag tct att ggc att tct aat ttt tct gcc cag   528
Asp Gln Gly Leu Ala Lys Ser Ile Gly Ile Ser Asn Phe Ser Ala Gln
                165                 170                 175
 
ttg att tat gat ttg att cgt ggt tgt acc att aaa cct gtc gcc tta   576
Leu Ile Tyr Asp Leu Ile Arg Gly Cys Thr Ile Lys Pro Val Ala Leu
            180                 185                 190
 
caa att gaa cat cat ccg tat ttg acc cag ccg aaa ttg gtc gaa tat   624
Gln Ile Glu His His Pro Tyr Leu Thr Gln Pro Lys Leu Val Glu Tyr
        195                 200                 205
 
gtt cag ttg cat gac att cag att acc ggt tat tct tct ttt ggt ccg   672
Val Gln Leu His Asp Ile Gln Ile Thr Gly Tyr Ser Ser Phe Gly Pro
    210                 215                 220
 
cag tct ttc ttg gaa atg gat ttg aag aga gca ttg gat acg ccg gtt   720
Gln Ser Phe Leu Glu Met Asp Leu Lys Arg Ala Leu Asp Thr Pro Val
225                 230                 235                 240
 
ttg ttg gaa gaa ccg acc gtt aaa tct att gcc gat aaa cat ggt aaa   768
Leu Leu Glu Glu Pro Thr Val Lys Ser Ile Ala Asp Lys His Gly Lys
                245                 250                 255
 
tct ccc gct cag gtt ttg ctt cgt tat cag acc caa aga ggt ata gca   816
Ser Pro Ala Gln Val Leu Leu Arg Tyr Gln Thr Gln Arg Gly Ile Ala
            260                 265                 270
 
gtt atc ccg cgt tct aat tct ccg gat cgt atg gcc caa aat ttg tct   864
Val Ile Pro Arg Ser Asn Ser Pro Asp Arg Met Ala Gln Asn Leu Ser
        275                 280                 285
 
gtc att gat ttt gaa ttg acc caa gat gat ttg cag gcc att gct gaa   912
Val Ile Asp Phe Glu Leu Thr Gln Asp Asp Leu Gln Ala Ile Ala Glu
    290                 295                 300
 
ttg gat tgt aat ttg cgt ttt aat gaa ccg tgg gat ttt tct aat att   960
Leu Asp Cys Asn Leu Arg Phe Asn Glu Pro Trp Asp Phe Ser Asn Ile
305                 310                 315                 320
 
ccg gtg ttt gtt                                                   972
Pro Val Phe Val

 

<210> 48
<211> 324
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in Z. mobilis

<400> 48
Met Ser Thr Ala Thr Ala Ser Pro Ala Val Lys Leu Asn Ser Gly Tyr
 1               5                  10                  15      
Glu Ile Pro Leu Val Gly Phe Gly Cys Trp Lys Leu Thr Asn Asp Val
            20                  25                  30          
Ala Ser Asp Gln Ile Tyr Arg Ala Ile Lys Ser Gly Tyr Arg Leu Phe
        35                  40                  45              
Asp Gly Ala Glu Asp Tyr Ala Asn Glu Gln Glu Val Gly Glu Gly Ile
    50                  55                  60                  
Lys Arg Ala Ile Lys Glu Gly Ile Val Lys Arg Glu Glu Leu Phe Ile
65                  70                  75                  80  
Thr Ser Lys Leu Trp Asn Ser Phe His Asp Lys Lys Asn Val Glu Val
                85                  90                  95      
Ala Leu Met Lys Thr Leu Ser Asp Leu Asn Leu Asp Tyr Val Asp Leu
            100                 105                 110         
Phe Tyr Ile His Phe Pro Ile Ala Gln Lys Pro Val Pro Ile Glu Lys
        115                 120                 125             
Lys Tyr Pro Pro Gly Phe Tyr Cys Gly Asp Gly Asp Lys Trp Ser Ile
    130                 135                 140                 
Glu Glu Val Pro Leu Leu Asp Thr Trp Arg Ala Leu Glu Lys Leu Val
145                 150                 155                 160 
Asp Gln Gly Leu Ala Lys Ser Ile Gly Ile Ser Asn Phe Ser Ala Gln
                165                 170                 175     
Leu Ile Tyr Asp Leu Ile Arg Gly Cys Thr Ile Lys Pro Val Ala Leu
            180                 185                 190         
Gln Ile Glu His His Pro Tyr Leu Thr Gln Pro Lys Leu Val Glu Tyr
        195                 200                 205             
Val Gln Leu His Asp Ile Gln Ile Thr Gly Tyr Ser Ser Phe Gly Pro
    210                 215                 220                 
Gln Ser Phe Leu Glu Met Asp Leu Lys Arg Ala Leu Asp Thr Pro Val
225                 230                 235                 240 
Leu Leu Glu Glu Pro Thr Val Lys Ser Ile Ala Asp Lys His Gly Lys
                245                 250                 255     
Ser Pro Ala Gln Val Leu Leu Arg Tyr Gln Thr Gln Arg Gly Ile Ala
            260                 265                 270         
Val Ile Pro Arg Ser Asn Ser Pro Asp Arg Met Ala Gln Asn Leu Ser
        275                 280                 285             
Val Ile Asp Phe Glu Leu Thr Gln Asp Asp Leu Gln Ala Ile Ala Glu
    290                 295                 300                 
Leu Asp Cys Asn Leu Arg Phe Asn Glu Pro Trp Asp Phe Ser Asn Ile
305                 310                 315                 320 
Pro Val Phe Val
                


<210> 49
<211> 1092
<212> DNA
<213> P. stipitis

<220> 
<221> CDS            
<222> (1)...(1092)

<400> 49
atg act gct aac cct tcc ttg gtg ttg aac aag atc gac gac att tcg   48
Met Thr Ala Asn Pro Ser Leu Val Leu Asn Lys Ile Asp Asp Ile Ser
 1               5                   10                  15
 
ttc gaa act tac gat gcc cca gaa atc tct gaa cct acc gat gtc ctc   96
Phe Glu Thr Tyr Asp Ala Pro Glu Ile Ser Glu Pro Thr Asp Val Leu
             20                  25                  30
 
gtc cag gtc aag aaa acc ggt atc tgt ggt tcc gac atc cac ttc tac   144
Val Gln Val Lys Lys Thr Gly Ile Cys Gly Ser Asp Ile His Phe Tyr
         35                  40                  45
 
gcc cat ggt aga atc ggt aac ttc gtt ttg acc aag cca atg gtc ttg   192
Ala His Gly Arg Ile Gly Asn Phe Val Leu Thr Lys Pro Met Val Leu
     50                  55                  60
 
ggt cac gaa tcc gcc ggt act gtt gtc cag gtt ggt aag ggt gtc acc   240
Gly His Glu Ser Ala Gly Thr Val Val Gln Val Gly Lys Gly Val Thr
 65                  70                  75                  80
 
tct ctt aag gtt ggt gac aac gtc gct atc gaa cca ggt att cca tcc   288
Ser Leu Lys Val Gly Asp Asn Val Ala Ile Glu Pro Gly Ile Pro Ser
                 85                  90                  95
 
aga ttc tcc gac gaa tac aag agc ggt cac tac aac ttg tgt cct cac   336
Arg Phe Ser Asp Glu Tyr Lys Ser Gly His Tyr Asn Leu Cys Pro His
            100                 105                 110
 
atg gcc ttc gcc gct act cct aac tcc aag gaa ggc gaa cca aac cca   384
Met Ala Phe Ala Ala Thr Pro Asn Ser Lys Glu Gly Glu Pro Asn Pro
        115                 120                 125
 
cca ggt acc tta tgt aag tac ttc aag tcg cca gaa gac ttc ttg gtc   432
Pro Gly Thr Leu Cys Lys Tyr Phe Lys Ser Pro Glu Asp Phe Leu Val
    130                 135                 140
 
aag ttg cca gac cac gtc agc ttg gaa ctc ggt gct ctt gtt gag cca   480
Lys Leu Pro Asp His Val Ser Leu Glu Leu Gly Ala Leu Val Glu Pro
145                 150                 155                 160
 
ttg tct gtt ggt gtc cac gcc tcc aag ttg ggt tcc gtt gct ttc ggc   528
Leu Ser Val Gly Val His Ala Ser Lys Leu Gly Ser Val Ala Phe Gly
                165                 170                 175
 
gac tac gtt gcc gtc ttt ggt gct ggt cct gtt ggt ctt ttg gct gct   576
Asp Tyr Val Ala Val Phe Gly Ala Gly Pro Val Gly Leu Leu Ala Ala
            180                 185                 190
 
gct gtc gcc aag acc ttc ggt gct aag ggt gtc atc gtc gtt gac att   624
Ala Val Ala Lys Thr Phe Gly Ala Lys Gly Val Ile Val Val Asp Ile
        195                 200                 205
 
ttc gac aac aag ttg aag atg gcc aag gac att ggt gct gct act cac   672
Phe Asp Asn Lys Leu Lys Met Ala Lys Asp Ile Gly Ala Ala Thr His
    210                 215                 220
 
acc ttc aac tcc aag acc ggt ggt tct gaa gaa ttg atc aag gct ttc   720
Thr Phe Asn Ser Lys Thr Gly Gly Ser Glu Glu Leu Ile Lys Ala Phe
225                 230                 235                 240
 
ggt ggt aac gtg cca aac gtc gtt ttg gaa tgt act ggt gct gaa cct   768
Gly Gly Asn Val Pro Asn Val Val Leu Glu Cys Thr Gly Ala Glu Pro
                245                 250                 255
 
tgt atc aag ttg ggt gtt gac gcc att gcc cca ggt ggt cgt ttc gtt   816
Cys Ile Lys Leu Gly Val Asp Ala Ile Ala Pro Gly Gly Arg Phe Val
            260                 265                 270
 
caa gtt ggt aac gct gct ggt cca gtc agc ttc cca atc acc gtt ttc   864
Gln Val Gly Asn Ala Ala Gly Pro Val Ser Phe Pro Ile Thr Val Phe
        275                 280                 285
 
gcc atg aag gaa ttg act ttg ttc ggt tct ttc aga tac gga ttc aac   912
Ala Met Lys Glu Leu Thr Leu Phe Gly Ser Phe Arg Tyr Gly Phe Asn
    290                 295                 300
 
gac tac aag act gct gtt gga atc ttt gac act aac tac caa aac ggt   960
Asp Tyr Lys Thr Ala Val Gly Ile Phe Asp Thr Asn Tyr Gln Asn Gly
305                 310                 315                 320
 
aga gaa aat gct cca att gac ttt gaa caa ttg atc acc cac aga tac   1008
Arg Glu Asn Ala Pro Ile Asp Phe Glu Gln Leu Ile Thr His Arg Tyr
                325                 330                 335
 
aag ttc aag gac gct att gaa gcc tac gac ttg gtc aga gcc ggt aag   1056
Lys Phe Lys Asp Ala Ile Glu Ala Tyr Asp Leu Val Arg Ala Gly Lys
            340                 345                 350
 
ggt gct gtc aag tgt ctc att gac ggc cct gag taa                   1092
Gly Ala Val Lys Cys Leu Ile Asp Gly Pro Glu  *
        355                 360
 

<210> 50
<211> 363
<212> PRT
<213> P. stipitis

<400> 50
Met Thr Ala Asn Pro Ser Leu Val Leu Asn Lys Ile Asp Asp Ile Ser
 1               5                  10                  15      
Phe Glu Thr Tyr Asp Ala Pro Glu Ile Ser Glu Pro Thr Asp Val Leu
            20                  25                  30          
Val Gln Val Lys Lys Thr Gly Ile Cys Gly Ser Asp Ile His Phe Tyr
        35                  40                  45              
Ala His Gly Arg Ile Gly Asn Phe Val Leu Thr Lys Pro Met Val Leu
    50                  55                  60                  
Gly His Glu Ser Ala Gly Thr Val Val Gln Val Gly Lys Gly Val Thr
65                  70                  75                  80  
Ser Leu Lys Val Gly Asp Asn Val Ala Ile Glu Pro Gly Ile Pro Ser
                85                  90                  95      
Arg Phe Ser Asp Glu Tyr Lys Ser Gly His Tyr Asn Leu Cys Pro His
            100                 105                 110         
Met Ala Phe Ala Ala Thr Pro Asn Ser Lys Glu Gly Glu Pro Asn Pro
        115                 120                 125             
Pro Gly Thr Leu Cys Lys Tyr Phe Lys Ser Pro Glu Asp Phe Leu Val
    130                 135                 140                 
Lys Leu Pro Asp His Val Ser Leu Glu Leu Gly Ala Leu Val Glu Pro
145                 150                 155                 160 
Leu Ser Val Gly Val His Ala Ser Lys Leu Gly Ser Val Ala Phe Gly
                165                 170                 175     
Asp Tyr Val Ala Val Phe Gly Ala Gly Pro Val Gly Leu Leu Ala Ala
            180                 185                 190         
Ala Val Ala Lys Thr Phe Gly Ala Lys Gly Val Ile Val Val Asp Ile
        195                 200                 205             
Phe Asp Asn Lys Leu Lys Met Ala Lys Asp Ile Gly Ala Ala Thr His
    210                 215                 220                 
Thr Phe Asn Ser Lys Thr Gly Gly Ser Glu Glu Leu Ile Lys Ala Phe
225                 230                 235                 240 
Gly Gly Asn Val Pro Asn Val Val Leu Glu Cys Thr Gly Ala Glu Pro
                245                 250                 255     
Cys Ile Lys Leu Gly Val Asp Ala Ile Ala Pro Gly Gly Arg Phe Val
            260                 265                 270         
Gln Val Gly Asn Ala Ala Gly Pro Val Ser Phe Pro Ile Thr Val Phe
        275                 280                 285             
Ala Met Lys Glu Leu Thr Leu Phe Gly Ser Phe Arg Tyr Gly Phe Asn
    290                 295                 300                 
Asp Tyr Lys Thr Ala Val Gly Ile Phe Asp Thr Asn Tyr Gln Asn Gly
305                 310                 315                 320 
Arg Glu Asn Ala Pro Ile Asp Phe Glu Gln Leu Ile Thr His Arg Tyr
                325                 330                 335     
Lys Phe Lys Asp Ala Ile Glu Ala Tyr Asp Leu Val Arg Ala Gly Lys
            340                 345                 350         
Gly Ala Val Lys Cys Leu Ile Asp Gly Pro Glu
        355                 360             


<210> 51
<211> 1089
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in S. cerevisiae

<220> 
<221> CDS            
<222> (1)...(1089)

<400> 51
atg act gct aat cca tct ttg gtt tta aat aaa att gat gac att tct   48
Met Thr Ala Asn Pro Ser Leu Val Leu Asn Lys Ile Asp Asp Ile Ser
 1               5                   10                  15
 
ttt gaa act tat gat gct cca gaa att tca gaa cct act gat gtt ttg   96
Phe Glu Thr Tyr Asp Ala Pro Glu Ile Ser Glu Pro Thr Asp Val Leu
             20                  25                  30
 
gta caa gtt aaa aag act gga att tgt ggt tct gac att cat ttt tat   144
Val Gln Val Lys Lys Thr Gly Ile Cys Gly Ser Asp Ile His Phe Tyr
         35                  40                  45
 
gct cat ggt aga att ggt aat ttc gtt ttg act aag cca atg gtt tta   192
Ala His Gly Arg Ile Gly Asn Phe Val Leu Thr Lys Pro Met Val Leu
     50                  55                  60
 
ggt cat gaa tct gct ggt act gtt gtt caa gtt ggt aaa ggt gtt act   240
Gly His Glu Ser Ala Gly Thr Val Val Gln Val Gly Lys Gly Val Thr
 65                  70                  75                  80
 
tct tta aaa gta ggt gat aat gtt gct att gaa cca gga ata cca tct   288
Ser Leu Lys Val Gly Asp Asn Val Ala Ile Glu Pro Gly Ile Pro Ser
                 85                  90                  95
 
aga ttt tct gat gaa tat aaa tct ggt cat tat aat ttg tgt cca cac   336
Arg Phe Ser Asp Glu Tyr Lys Ser Gly His Tyr Asn Leu Cys Pro His
            100                 105                 110
 
atg gct ttt gct gct acc cca aat tct aaa gaa ggt gaa cca aat cca   384
Met Ala Phe Ala Ala Thr Pro Asn Ser Lys Glu Gly Glu Pro Asn Pro
        115                 120                 125
 
cca ggt aca ttg tgt aaa tat ttt aaa tct cct gaa gac ttt ttg gtt   432
Pro Gly Thr Leu Cys Lys Tyr Phe Lys Ser Pro Glu Asp Phe Leu Val
    130                 135                 140
 
aaa ttg cca gat cat gtt tca ttg gaa ttg ggt gct ttg gtt gaa cca   480
Lys Leu Pro Asp His Val Ser Leu Glu Leu Gly Ala Leu Val Glu Pro
145                 150                 155                 160
 
ttg tct gtt ggt gtt cat gct tct aaa ttg ggt tct gtt gct ttt ggc   528
Leu Ser Val Gly Val His Ala Ser Lys Leu Gly Ser Val Ala Phe Gly
                165                 170                 175
 
gat tac gtt gct gtt ttc ggt gct ggt cca gtt ggt ttg ttg gca gcc   576
Asp Tyr Val Ala Val Phe Gly Ala Gly Pro Val Gly Leu Leu Ala Ala
            180                 185                 190
 
gca gtt gct aaa act ttt gga gct aaa ggt gta att gtt gtt gac att   624
Ala Val Ala Lys Thr Phe Gly Ala Lys Gly Val Ile Val Val Asp Ile
        195                 200                 205
 
ttt gat aat aaa tta aaa atg gct aaa gat ata ggt gca gca act cat   672
Phe Asp Asn Lys Leu Lys Met Ala Lys Asp Ile Gly Ala Ala Thr His
    210                 215                 220
 
act ttt aat tct aaa act ggt ggt tct gaa gaa ttg att aaa gca ttt   720
Thr Phe Asn Ser Lys Thr Gly Gly Ser Glu Glu Leu Ile Lys Ala Phe
225                 230                 235                 240
 
gga gga aat gtt cca aac gtt gtt tta gaa tgt act ggt gct gag cca   768
Gly Gly Asn Val Pro Asn Val Val Leu Glu Cys Thr Gly Ala Glu Pro
                245                 250                 255
 
tgt att aaa ttg ggt gtt gat gct att gct cca ggt ggt aga ttt gtc   816
Cys Ile Lys Leu Gly Val Asp Ala Ile Ala Pro Gly Gly Arg Phe Val
            260                 265                 270
 
caa gtt ggt aat gct gct ggt cct gta tct ttt cca att act gtt ttt   864
Gln Val Gly Asn Ala Ala Gly Pro Val Ser Phe Pro Ile Thr Val Phe
        275                 280                 285
 
gct atg aaa gaa ttg aca ttg ttt gga tct ttt aga tat ggt ttt aat   912
Ala Met Lys Glu Leu Thr Leu Phe Gly Ser Phe Arg Tyr Gly Phe Asn
    290                 295                 300
 
gat tat aaa act gct gtt gga att ttc gat act aat tat caa aat ggt   960
Asp Tyr Lys Thr Ala Val Gly Ile Phe Asp Thr Asn Tyr Gln Asn Gly
305                 310                 315                 320
 
aga gaa aat gct cct att gat ttt gaa caa ttg att act cat aga tat   1008
Arg Glu Asn Ala Pro Ile Asp Phe Glu Gln Leu Ile Thr His Arg Tyr
                325                 330                 335
 
aaa ttt aaa gat gct att gag gct tat gat ttg gtt aga gct ggt aaa   1056
Lys Phe Lys Asp Ala Ile Glu Ala Tyr Asp Leu Val Arg Ala Gly Lys
            340                 345                 350
 
ggt gct gtt aaa tgt ttg att gat ggt cca gaa                       1089
Gly Ala Val Lys Cys Leu Ile Asp Gly Pro Glu
        355                 360
 

<210> 52
<211> 363
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in S. cerevisiae

<400> 52
Met Thr Ala Asn Pro Ser Leu Val Leu Asn Lys Ile Asp Asp Ile Ser
 1               5                  10                  15      
Phe Glu Thr Tyr Asp Ala Pro Glu Ile Ser Glu Pro Thr Asp Val Leu
            20                  25                  30          
Val Gln Val Lys Lys Thr Gly Ile Cys Gly Ser Asp Ile His Phe Tyr
        35                  40                  45              
Ala His Gly Arg Ile Gly Asn Phe Val Leu Thr Lys Pro Met Val Leu
    50                  55                  60                  
Gly His Glu Ser Ala Gly Thr Val Val Gln Val Gly Lys Gly Val Thr
65                  70                  75                  80  
Ser Leu Lys Val Gly Asp Asn Val Ala Ile Glu Pro Gly Ile Pro Ser
                85                  90                  95      
Arg Phe Ser Asp Glu Tyr Lys Ser Gly His Tyr Asn Leu Cys Pro His
            100                 105                 110         
Met Ala Phe Ala Ala Thr Pro Asn Ser Lys Glu Gly Glu Pro Asn Pro
        115                 120                 125             
Pro Gly Thr Leu Cys Lys Tyr Phe Lys Ser Pro Glu Asp Phe Leu Val
    130                 135                 140                 
Lys Leu Pro Asp His Val Ser Leu Glu Leu Gly Ala Leu Val Glu Pro
145                 150                 155                 160 
Leu Ser Val Gly Val His Ala Ser Lys Leu Gly Ser Val Ala Phe Gly
                165                 170                 175     
Asp Tyr Val Ala Val Phe Gly Ala Gly Pro Val Gly Leu Leu Ala Ala
            180                 185                 190         
Ala Val Ala Lys Thr Phe Gly Ala Lys Gly Val Ile Val Val Asp Ile
        195                 200                 205             
Phe Asp Asn Lys Leu Lys Met Ala Lys Asp Ile Gly Ala Ala Thr His
    210                 215                 220                 
Thr Phe Asn Ser Lys Thr Gly Gly Ser Glu Glu Leu Ile Lys Ala Phe
225                 230                 235                 240 
Gly Gly Asn Val Pro Asn Val Val Leu Glu Cys Thr Gly Ala Glu Pro
                245                 250                 255     
Cys Ile Lys Leu Gly Val Asp Ala Ile Ala Pro Gly Gly Arg Phe Val
            260                 265                 270         
Gln Val Gly Asn Ala Ala Gly Pro Val Ser Phe Pro Ile Thr Val Phe
        275                 280                 285             
Ala Met Lys Glu Leu Thr Leu Phe Gly Ser Phe Arg Tyr Gly Phe Asn
    290                 295                 300                 
Asp Tyr Lys Thr Ala Val Gly Ile Phe Asp Thr Asn Tyr Gln Asn Gly
305                 310                 315                 320 
Arg Glu Asn Ala Pro Ile Asp Phe Glu Gln Leu Ile Thr His Arg Tyr
                325                 330                 335     
Lys Phe Lys Asp Ala Ile Glu Ala Tyr Asp Leu Val Arg Ala Gly Lys
            340                 345                 350         
Gly Ala Val Lys Cys Leu Ile Asp Gly Pro Glu
        355                 360             


<210> 53
<211> 1111
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in S. cerevisiae

<220> 
<221> CDS            
<222> (12)...(1100)

<400> 53
tactcaagct t atg act gct aat cca tct ttg gtt tta aat aaa att gat  50
             Met Thr Ala Asn Pro Ser Leu Val Leu Asn Lys Ile Asp
              1               5                   10
 
gac att tct ttt gaa act tat gat gct cca gaa att tca gaa cct act   98
Asp Ile Ser Phe Glu Thr Tyr Asp Ala Pro Glu Ile Ser Glu Pro Thr
     15                  20                  25
 
gat gtt ttg gta caa gtt aaa aag act gga att tgt ggt tct gac att   146
Asp Val Leu Val Gln Val Lys Lys Thr Gly Ile Cys Gly Ser Asp Ile
 30                  35                  40                  45
 
cat ttt tat gct cat ggt aga att ggt aat ttc gtt ttg act aag cca   194
His Phe Tyr Ala His Gly Arg Ile Gly Asn Phe Val Leu Thr Lys Pro
                 50                  55                  60
 
atg gtt tta ggt cat gaa tct gct ggt act gtt gtt caa gtt ggt aaa   242
Met Val Leu Gly His Glu Ser Ala Gly Thr Val Val Gln Val Gly Lys
             65                  70                  75
 
ggt gtt act tct tta aaa gta ggt gat aat gtt gct att gaa cca gga   290
Gly Val Thr Ser Leu Lys Val Gly Asp Asn Val Ala Ile Glu Pro Gly
         80                  85                  90
 
ata cca tct aga ttt tct gat gaa tat aaa tct ggt cat tat aat ttg   338
Ile Pro Ser Arg Phe Ser Asp Glu Tyr Lys Ser Gly His Tyr Asn Leu
     95                 100                 105
 
tgt cca cac atg gct ttt gct gct acc cca aat tct aaa gaa ggt gaa   386
Cys Pro His Met Ala Phe Ala Ala Thr Pro Asn Ser Lys Glu Gly Glu
110                 115                 120                 125
 
cca aat cca cca ggt aca ttg tgt aaa tat ttt aaa tct cct gaa gac   434
Pro Asn Pro Pro Gly Thr Leu Cys Lys Tyr Phe Lys Ser Pro Glu Asp
                130                 135                 140
 
ttt ttg gtt aaa ttg cca gat cat gtt tca ttg gaa ttg ggt gct ttg   482
Phe Leu Val Lys Leu Pro Asp His Val Ser Leu Glu Leu Gly Ala Leu
            145                 150                 155
 
gtt gaa cca ttg tct gtt ggt gtt cat gct tct aaa ttg ggt tct gtt   530
Val Glu Pro Leu Ser Val Gly Val His Ala Ser Lys Leu Gly Ser Val
        160                 165                 170
 
gct ttt ggc gat tac gtt gct gtt ttc ggt gct ggt cca gtt ggt ttg   578
Ala Phe Gly Asp Tyr Val Ala Val Phe Gly Ala Gly Pro Val Gly Leu
    175                 180                 185
 
ttg gca gcc gca gtt gct aaa act ttt gga gct aaa ggt gta att gtt   626
Leu Ala Ala Ala Val Ala Lys Thr Phe Gly Ala Lys Gly Val Ile Val
190                 195                 200                 205
 
gtt gac att ttt gat aat aaa tta aaa atg gct aaa gat ata ggt gca   674
Val Asp Ile Phe Asp Asn Lys Leu Lys Met Ala Lys Asp Ile Gly Ala
                210                 215                 220
 
gca act cat act ttt aat tct aaa act ggt ggt tct gaa gaa ttg att   722
Ala Thr His Thr Phe Asn Ser Lys Thr Gly Gly Ser Glu Glu Leu Ile
            225                 230                 235
 
aaa gca ttt gga gga aat gtt cca aac gtt gtt tta gaa tgt act ggt   770
Lys Ala Phe Gly Gly Asn Val Pro Asn Val Val Leu Glu Cys Thr Gly
        240                 245                 250
 
gct gag cca tgt att aaa ttg ggt gtt gat gct att gct cca ggt ggt   818
Ala Glu Pro Cys Ile Lys Leu Gly Val Asp Ala Ile Ala Pro Gly Gly
    255                 260                 265
 
aga ttt gtc caa gtt ggt aat gct gct ggt cct gta tct ttt cca att   866
Arg Phe Val Gln Val Gly Asn Ala Ala Gly Pro Val Ser Phe Pro Ile
270                 275                 280                 285
 
act gtt ttt gct atg aaa gaa ttg aca ttg ttt gga tct ttt aga tat   914
Thr Val Phe Ala Met Lys Glu Leu Thr Leu Phe Gly Ser Phe Arg Tyr
                290                 295                 300
 
ggt ttt aat gat tat aaa act gct gtt gga att ttc gat act aat tat   962
Gly Phe Asn Asp Tyr Lys Thr Ala Val Gly Ile Phe Asp Thr Asn Tyr
            305                 310                 315
 
caa aat ggt aga gaa aat gct cct att gat ttt gaa caa ttg att act   1010
Gln Asn Gly Arg Glu Asn Ala Pro Ile Asp Phe Glu Gln Leu Ile Thr
        320                 325                 330
 
cat aga tat aaa ttt aaa gat gct att gag gct tat gat ttg gtt aga   1058
His Arg Tyr Lys Phe Lys Asp Ala Ile Glu Ala Tyr Asp Leu Val Arg
    335                 340                 345
 
gct ggt aaa ggt gct gtt aaa tgt ttg att gat ggt cca gaa           1100
Ala Gly Lys Gly Ala Val Lys Cys Leu Ile Asp Gly Pro Glu
350                 355                 360
 
gaattccgat g                                                      1111

<210> 54
<211> 363
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in S. cerevisiae

<400> 54
Met Thr Ala Asn Pro Ser Leu Val Leu Asn Lys Ile Asp Asp Ile Ser
 1               5                  10                  15      
Phe Glu Thr Tyr Asp Ala Pro Glu Ile Ser Glu Pro Thr Asp Val Leu
            20                  25                  30          
Val Gln Val Lys Lys Thr Gly Ile Cys Gly Ser Asp Ile His Phe Tyr
        35                  40                  45              
Ala His Gly Arg Ile Gly Asn Phe Val Leu Thr Lys Pro Met Val Leu
    50                  55                  60                  
Gly His Glu Ser Ala Gly Thr Val Val Gln Val Gly Lys Gly Val Thr
65                  70                  75                  80  
Ser Leu Lys Val Gly Asp Asn Val Ala Ile Glu Pro Gly Ile Pro Ser
                85                  90                  95      
Arg Phe Ser Asp Glu Tyr Lys Ser Gly His Tyr Asn Leu Cys Pro His
            100                 105                 110         
Met Ala Phe Ala Ala Thr Pro Asn Ser Lys Glu Gly Glu Pro Asn Pro
        115                 120                 125             
Pro Gly Thr Leu Cys Lys Tyr Phe Lys Ser Pro Glu Asp Phe Leu Val
    130                 135                 140                 
Lys Leu Pro Asp His Val Ser Leu Glu Leu Gly Ala Leu Val Glu Pro
145                 150                 155                 160 
Leu Ser Val Gly Val His Ala Ser Lys Leu Gly Ser Val Ala Phe Gly
                165                 170                 175     
Asp Tyr Val Ala Val Phe Gly Ala Gly Pro Val Gly Leu Leu Ala Ala
            180                 185                 190         
Ala Val Ala Lys Thr Phe Gly Ala Lys Gly Val Ile Val Val Asp Ile
        195                 200                 205             
Phe Asp Asn Lys Leu Lys Met Ala Lys Asp Ile Gly Ala Ala Thr His
    210                 215                 220                 
Thr Phe Asn Ser Lys Thr Gly Gly Ser Glu Glu Leu Ile Lys Ala Phe
225                 230                 235                 240 
Gly Gly Asn Val Pro Asn Val Val Leu Glu Cys Thr Gly Ala Glu Pro
                245                 250                 255     
Cys Ile Lys Leu Gly Val Asp Ala Ile Ala Pro Gly Gly Arg Phe Val
            260                 265                 270         
Gln Val Gly Asn Ala Ala Gly Pro Val Ser Phe Pro Ile Thr Val Phe
        275                 280                 285             
Ala Met Lys Glu Leu Thr Leu Phe Gly Ser Phe Arg Tyr Gly Phe Asn
    290                 295                 300                 
Asp Tyr Lys Thr Ala Val Gly Ile Phe Asp Thr Asn Tyr Gln Asn Gly
305                 310                 315                 320 
Arg Glu Asn Ala Pro Ile Asp Phe Glu Gln Leu Ile Thr His Arg Tyr
                325                 330                 335     
Lys Phe Lys Asp Ala Ile Glu Ala Tyr Asp Leu Val Arg Ala Gly Lys
            340                 345                 350         
Gly Ala Val Lys Cys Leu Ile Asp Gly Pro Glu
        355                 360             


<210> 55
<211> 1117
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in S. cerevisiae

<220> 
<221> CDS            
<222> (15)...(1103)

<400> 55
gaatactcca tatg atg act gct aat cca tct ttg gtt tta aat aaa att   50
                Met Thr Ala Asn Pro Ser Leu Val Leu Asn Lys Ile
                 1               5                   10
 
gat gac att tct ttt gaa act tat gat gct cca gaa att tca gaa cct   98
Asp Asp Ile Ser Phe Glu Thr Tyr Asp Ala Pro Glu Ile Ser Glu Pro
         15                  20                  25
 
act gat gtt ttg gta caa gtt aaa aag act gga att tgt ggt tct gac   146
Thr Asp Val Leu Val Gln Val Lys Lys Thr Gly Ile Cys Gly Ser Asp
     30                  35                  40
 
att cat ttt tat gct cat ggt aga att ggt aat ttc gtt ttg act aag   194
Ile His Phe Tyr Ala His Gly Arg Ile Gly Asn Phe Val Leu Thr Lys
 45                  50                  55                  60
 
cca atg gtt tta ggt cat gaa tct gct ggt act gtt gtt caa gtt ggt   242
Pro Met Val Leu Gly His Glu Ser Ala Gly Thr Val Val Gln Val Gly
                 65                  70                  75
 
aaa ggt gtt act tct tta aaa gta ggt gat aat gtt gct att gaa cca   290
Lys Gly Val Thr Ser Leu Lys Val Gly Asp Asn Val Ala Ile Glu Pro
             80                  85                  90
 
gga ata cca tct aga ttt tct gat gaa tat aaa tct ggt cat tat aat   338
Gly Ile Pro Ser Arg Phe Ser Asp Glu Tyr Lys Ser Gly His Tyr Asn
         95                 100                 105
 
ttg tgt cca cac atg gct ttt gct gct acc cca aat tct aaa gaa ggt   386
Leu Cys Pro His Met Ala Phe Ala Ala Thr Pro Asn Ser Lys Glu Gly
    110                 115                 120
 
gaa cca aat cca cca ggt aca ttg tgt aaa tat ttt aaa tct cct gaa   434
Glu Pro Asn Pro Pro Gly Thr Leu Cys Lys Tyr Phe Lys Ser Pro Glu
125                 130                 135                 140
 
gac ttt ttg gtt aaa ttg cca gat cat gtt tca ttg gaa ttg ggt gct   482
Asp Phe Leu Val Lys Leu Pro Asp His Val Ser Leu Glu Leu Gly Ala
                145                 150                 155
 
ttg gtt gaa cca ttg tct gtt ggt gtt cat gct tct aaa ttg ggt tct   530
Leu Val Glu Pro Leu Ser Val Gly Val His Ala Ser Lys Leu Gly Ser
            160                 165                 170
 
gtt gct ttt ggc gat tac gtt gct gtt ttc ggt gct ggt cca gtt ggt   578
Val Ala Phe Gly Asp Tyr Val Ala Val Phe Gly Ala Gly Pro Val Gly
        175                 180                 185
 
ttg ttg gca gcc gca gtt gct aaa act ttt gga gct aaa ggt gta att   626
Leu Leu Ala Ala Ala Val Ala Lys Thr Phe Gly Ala Lys Gly Val Ile
    190                 195                 200
 
gtt gtt gac att ttt gat aat aaa tta aaa atg gct aaa gat ata ggt   674
Val Val Asp Ile Phe Asp Asn Lys Leu Lys Met Ala Lys Asp Ile Gly
205                 210                 215                 220
 
gca gca act cat act ttt aat tct aaa act ggt ggt tct gaa gaa ttg   722
Ala Ala Thr His Thr Phe Asn Ser Lys Thr Gly Gly Ser Glu Glu Leu
                225                 230                 235
 
att aaa gca ttt gga gga aat gtt cca aac gtt gtt tta gaa tgt act   770
Ile Lys Ala Phe Gly Gly Asn Val Pro Asn Val Val Leu Glu Cys Thr
            240                 245                 250
 
ggt gct gag cca tgt att aaa ttg ggt gtt gat gct att gct cca ggt   818
Gly Ala Glu Pro Cys Ile Lys Leu Gly Val Asp Ala Ile Ala Pro Gly
        255                 260                 265
 
ggt aga ttt gtc caa gtt ggt aat gct gct ggt cct gta tct ttt cca   866
Gly Arg Phe Val Gln Val Gly Asn Ala Ala Gly Pro Val Ser Phe Pro
    270                 275                 280
 
att act gtt ttt gct atg aaa gaa ttg aca ttg ttt gga tct ttt aga   914
Ile Thr Val Phe Ala Met Lys Glu Leu Thr Leu Phe Gly Ser Phe Arg
285                 290                 295                 300
 
tat ggt ttt aat gat tat aaa act gct gtt gga att ttc gat act aat   962
Tyr Gly Phe Asn Asp Tyr Lys Thr Ala Val Gly Ile Phe Asp Thr Asn
                305                 310                 315
 
tat caa aat ggt aga gaa aat gct cct att gat ttt gaa caa ttg att   1010
Tyr Gln Asn Gly Arg Glu Asn Ala Pro Ile Asp Phe Glu Gln Leu Ile
            320                 325                 330
 
act cat aga tat aaa ttt aaa gat gct att gag gct tat gat ttg gtt   1058
Thr His Arg Tyr Lys Phe Lys Asp Ala Ile Glu Ala Tyr Asp Leu Val
        335                 340                 345
 
aga gct ggt aaa ggt gct gtt aaa tgt ttg att gat ggt cca gaa       1103
Arg Ala Gly Lys Gly Ala Val Lys Cys Leu Ile Asp Gly Pro Glu
    350                 355                 360
 
actagtcgat gcct                                                   1117

<210> 56
<211> 363
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in S. cerevisiae

<400> 56
Met Thr Ala Asn Pro Ser Leu Val Leu Asn Lys Ile Asp Asp Ile Ser
 1               5                  10                  15      
Phe Glu Thr Tyr Asp Ala Pro Glu Ile Ser Glu Pro Thr Asp Val Leu
            20                  25                  30          
Val Gln Val Lys Lys Thr Gly Ile Cys Gly Ser Asp Ile His Phe Tyr
        35                  40                  45              
Ala His Gly Arg Ile Gly Asn Phe Val Leu Thr Lys Pro Met Val Leu
    50                  55                  60                  
Gly His Glu Ser Ala Gly Thr Val Val Gln Val Gly Lys Gly Val Thr
65                  70                  75                  80  
Ser Leu Lys Val Gly Asp Asn Val Ala Ile Glu Pro Gly Ile Pro Ser
                85                  90                  95      
Arg Phe Ser Asp Glu Tyr Lys Ser Gly His Tyr Asn Leu Cys Pro His
            100                 105                 110         
Met Ala Phe Ala Ala Thr Pro Asn Ser Lys Glu Gly Glu Pro Asn Pro
        115                 120                 125             
Pro Gly Thr Leu Cys Lys Tyr Phe Lys Ser Pro Glu Asp Phe Leu Val
    130                 135                 140                 
Lys Leu Pro Asp His Val Ser Leu Glu Leu Gly Ala Leu Val Glu Pro
145                 150                 155                 160 
Leu Ser Val Gly Val His Ala Ser Lys Leu Gly Ser Val Ala Phe Gly
                165                 170                 175     
Asp Tyr Val Ala Val Phe Gly Ala Gly Pro Val Gly Leu Leu Ala Ala
            180                 185                 190         
Ala Val Ala Lys Thr Phe Gly Ala Lys Gly Val Ile Val Val Asp Ile
        195                 200                 205             
Phe Asp Asn Lys Leu Lys Met Ala Lys Asp Ile Gly Ala Ala Thr His
    210                 215                 220                 
Thr Phe Asn Ser Lys Thr Gly Gly Ser Glu Glu Leu Ile Lys Ala Phe
225                 230                 235                 240 
Gly Gly Asn Val Pro Asn Val Val Leu Glu Cys Thr Gly Ala Glu Pro
                245                 250                 255     
Cys Ile Lys Leu Gly Val Asp Ala Ile Ala Pro Gly Gly Arg Phe Val
            260                 265                 270         
Gln Val Gly Asn Ala Ala Gly Pro Val Ser Phe Pro Ile Thr Val Phe
        275                 280                 285             
Ala Met Lys Glu Leu Thr Leu Phe Gly Ser Phe Arg Tyr Gly Phe Asn
    290                 295                 300                 
Asp Tyr Lys Thr Ala Val Gly Ile Phe Asp Thr Asn Tyr Gln Asn Gly
305                 310                 315                 320 
Arg Glu Asn Ala Pro Ile Asp Phe Glu Gln Leu Ile Thr His Arg Tyr
                325                 330                 335     
Lys Phe Lys Asp Ala Ile Glu Ala Tyr Asp Leu Val Arg Ala Gly Lys
            340                 345                 350         
Gly Ala Val Lys Cys Leu Ile Asp Gly Pro Glu
        355                 360             


<210> 57
<211> 1089
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in E. coli

<220> 
<221> CDS            
<222> (1)...(1089)

<400> 57
atg act gct aat cca tct ttg gtt tta aat aaa att gat gac att tct   48
Met Thr Ala Asn Pro Ser Leu Val Leu Asn Lys Ile Asp Asp Ile Ser
 1               5                   10                  15
 
ttt gaa act tat gat gct cca gaa att tca gaa cct act gat gtt ttg   96
Phe Glu Thr Tyr Asp Ala Pro Glu Ile Ser Glu Pro Thr Asp Val Leu
             20                  25                  30
 
gta caa gtt aaa aag act gga att tgt ggt tct gac att cat ttt tat   144
Val Gln Val Lys Lys Thr Gly Ile Cys Gly Ser Asp Ile His Phe Tyr
         35                  40                  45
 
gct cat ggt aga att ggt aat ttc gtt ttg act aag cca atg gtt tta   192
Ala His Gly Arg Ile Gly Asn Phe Val Leu Thr Lys Pro Met Val Leu
     50                  55                  60
 
ggt cat gaa tct gct ggt act gtt gtt caa gtt ggt aaa ggt gtt act   240
Gly His Glu Ser Ala Gly Thr Val Val Gln Val Gly Lys Gly Val Thr
 65                  70                  75                  80
 
tct tta aaa gta ggt gat aat gtt gct att gaa cca gga ata cca tct   288
Ser Leu Lys Val Gly Asp Asn Val Ala Ile Glu Pro Gly Ile Pro Ser
                 85                  90                  95
 
aga ttt tct gat gaa tat aaa tct ggt cat tat aat ttg tgt cca cac   336
Arg Phe Ser Asp Glu Tyr Lys Ser Gly His Tyr Asn Leu Cys Pro His
            100                 105                 110
 
atg gct ttt gct gct acc cca aat tct aaa gaa ggt gaa cca aat cca   384
Met Ala Phe Ala Ala Thr Pro Asn Ser Lys Glu Gly Glu Pro Asn Pro
        115                 120                 125
 
cca ggt aca ttg tgt aaa tat ttt aaa tct cct gaa gac ttt ttg gtt   432
Pro Gly Thr Leu Cys Lys Tyr Phe Lys Ser Pro Glu Asp Phe Leu Val
    130                 135                 140
 
aaa ttg cca gat cat gtt tca ttg gaa ttg ggt gct ttg gtt gaa cca   480
Lys Leu Pro Asp His Val Ser Leu Glu Leu Gly Ala Leu Val Glu Pro
145                 150                 155                 160
 
ttg tct gtt ggt gtt cat gct tct aaa ttg ggt tct gtt gct ttt ggc   528
Leu Ser Val Gly Val His Ala Ser Lys Leu Gly Ser Val Ala Phe Gly
                165                 170                 175
 
gat tac gtt gct gtt ttc ggt gct ggt cca gtt ggt ttg ttg gca gcc   576
Asp Tyr Val Ala Val Phe Gly Ala Gly Pro Val Gly Leu Leu Ala Ala
            180                 185                 190
 
gca gtt gct aaa act ttt gga gct aaa ggt gta att gtt gtt gac att   624
Ala Val Ala Lys Thr Phe Gly Ala Lys Gly Val Ile Val Val Asp Ile
        195                 200                 205
 
ttt gat aat aaa tta aaa atg gct aaa gat ata ggt gca gca act cat   672
Phe Asp Asn Lys Leu Lys Met Ala Lys Asp Ile Gly Ala Ala Thr His
    210                 215                 220
 
act ttt aat tct aaa act ggt ggt tct gaa gaa ttg att aaa gca ttt   720
Thr Phe Asn Ser Lys Thr Gly Gly Ser Glu Glu Leu Ile Lys Ala Phe
225                 230                 235                 240
 
gga gga aat gtt cca aac gtt gtt tta gaa tgt act ggt gct gag cca   768
Gly Gly Asn Val Pro Asn Val Val Leu Glu Cys Thr Gly Ala Glu Pro
                245                 250                 255
 
tgt att aaa ttg ggt gtt gat gct att gct cca ggt ggt aga ttt gtc   816
Cys Ile Lys Leu Gly Val Asp Ala Ile Ala Pro Gly Gly Arg Phe Val
            260                 265                 270
 
caa gtt ggt aat gct gct ggt cct gta tct ttt cca att act gtt ttt   864
Gln Val Gly Asn Ala Ala Gly Pro Val Ser Phe Pro Ile Thr Val Phe
        275                 280                 285
 
gct atg aaa gaa ttg aca ttg ttt gga tct ttt aga tat ggt ttt aat   912
Ala Met Lys Glu Leu Thr Leu Phe Gly Ser Phe Arg Tyr Gly Phe Asn
    290                 295                 300
 
gat tat aaa act gct gtt gga att ttc gat act aat tat caa aat ggt   960
Asp Tyr Lys Thr Ala Val Gly Ile Phe Asp Thr Asn Tyr Gln Asn Gly
305                 310                 315                 320
 
aga gaa aat gct cct att gat ttt gaa caa ttg att act cat aga tat   1008
Arg Glu Asn Ala Pro Ile Asp Phe Glu Gln Leu Ile Thr His Arg Tyr
                325                 330                 335
 
aaa ttt aaa gat gct att gag gct tat gat ttg gtt aga gct ggt aaa   1056
Lys Phe Lys Asp Ala Ile Glu Ala Tyr Asp Leu Val Arg Ala Gly Lys
            340                 345                 350
 
ggt gct gtt aaa tgt ttg att gat ggt cca gaa                       1089
Gly Ala Val Lys Cys Leu Ile Asp Gly Pro Glu
        355                 360
 

<210> 58
<211> 363
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in E. coli

<400> 58
Met Thr Ala Asn Pro Ser Leu Val Leu Asn Lys Ile Asp Asp Ile Ser
 1               5                  10                  15      
Phe Glu Thr Tyr Asp Ala Pro Glu Ile Ser Glu Pro Thr Asp Val Leu
            20                  25                  30          
Val Gln Val Lys Lys Thr Gly Ile Cys Gly Ser Asp Ile His Phe Tyr
        35                  40                  45              
Ala His Gly Arg Ile Gly Asn Phe Val Leu Thr Lys Pro Met Val Leu
    50                  55                  60                  
Gly His Glu Ser Ala Gly Thr Val Val Gln Val Gly Lys Gly Val Thr
65                  70                  75                  80  
Ser Leu Lys Val Gly Asp Asn Val Ala Ile Glu Pro Gly Ile Pro Ser
                85                  90                  95      
Arg Phe Ser Asp Glu Tyr Lys Ser Gly His Tyr Asn Leu Cys Pro His
            100                 105                 110         
Met Ala Phe Ala Ala Thr Pro Asn Ser Lys Glu Gly Glu Pro Asn Pro
        115                 120                 125             
Pro Gly Thr Leu Cys Lys Tyr Phe Lys Ser Pro Glu Asp Phe Leu Val
    130                 135                 140                 
Lys Leu Pro Asp His Val Ser Leu Glu Leu Gly Ala Leu Val Glu Pro
145                 150                 155                 160 
Leu Ser Val Gly Val His Ala Ser Lys Leu Gly Ser Val Ala Phe Gly
                165                 170                 175     
Asp Tyr Val Ala Val Phe Gly Ala Gly Pro Val Gly Leu Leu Ala Ala
            180                 185                 190         
Ala Val Ala Lys Thr Phe Gly Ala Lys Gly Val Ile Val Val Asp Ile
        195                 200                 205             
Phe Asp Asn Lys Leu Lys Met Ala Lys Asp Ile Gly Ala Ala Thr His
    210                 215                 220                 
Thr Phe Asn Ser Lys Thr Gly Gly Ser Glu Glu Leu Ile Lys Ala Phe
225                 230                 235                 240 
Gly Gly Asn Val Pro Asn Val Val Leu Glu Cys Thr Gly Ala Glu Pro
                245                 250                 255     
Cys Ile Lys Leu Gly Val Asp Ala Ile Ala Pro Gly Gly Arg Phe Val
            260                 265                 270         
Gln Val Gly Asn Ala Ala Gly Pro Val Ser Phe Pro Ile Thr Val Phe
        275                 280                 285             
Ala Met Lys Glu Leu Thr Leu Phe Gly Ser Phe Arg Tyr Gly Phe Asn
    290                 295                 300                 
Asp Tyr Lys Thr Ala Val Gly Ile Phe Asp Thr Asn Tyr Gln Asn Gly
305                 310                 315                 320 
Arg Glu Asn Ala Pro Ile Asp Phe Glu Gln Leu Ile Thr His Arg Tyr
                325                 330                 335     
Lys Phe Lys Asp Ala Ile Glu Ala Tyr Asp Leu Val Arg Ala Gly Lys
            340                 345                 350         
Gly Ala Val Lys Cys Leu Ile Asp Gly Pro Glu
        355                 360             


<210> 59
<211> 1112
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in E. coli

<220> 
<221> CDS            
<222> (13)...(1101)

<400> 59
ttactcaagc tt atg act gct aat cca tct ttg gtt tta aat aaa att gat 51
              Met Thr Ala Asn Pro Ser Leu Val Leu Asn Lys Ile Asp
               1               5                   10
 
gac att tct ttt gaa act tat gat gct cca gaa att tca gaa cct act   99
Asp Ile Ser Phe Glu Thr Tyr Asp Ala Pro Glu Ile Ser Glu Pro Thr
     15                  20                  25
 
gat gtt ttg gta caa gtt aaa aag act gga att tgt ggt tct gac att   147
Asp Val Leu Val Gln Val Lys Lys Thr Gly Ile Cys Gly Ser Asp Ile
 30                  35                  40                  45
 
cat ttt tat gct cat ggt aga att ggt aat ttc gtt ttg act aag cca   195
His Phe Tyr Ala His Gly Arg Ile Gly Asn Phe Val Leu Thr Lys Pro
                 50                  55                  60
 
atg gtt tta ggt cat gaa tct gct ggt act gtt gtt caa gtt ggt aaa   243
Met Val Leu Gly His Glu Ser Ala Gly Thr Val Val Gln Val Gly Lys
             65                  70                  75
 
ggt gtt act tct tta aaa gta ggt gat aat gtt gct att gaa cca gga   291
Gly Val Thr Ser Leu Lys Val Gly Asp Asn Val Ala Ile Glu Pro Gly
         80                  85                  90
 
ata cca tct aga ttt tct gat gaa tat aaa tct ggt cat tat aat ttg   339
Ile Pro Ser Arg Phe Ser Asp Glu Tyr Lys Ser Gly His Tyr Asn Leu
     95                 100                 105
 
tgt cca cac atg gct ttt gct gct acc cca aat tct aaa gaa ggt gaa   387
Cys Pro His Met Ala Phe Ala Ala Thr Pro Asn Ser Lys Glu Gly Glu
110                 115                 120                 125
 
cca aat cca cca ggt aca ttg tgt aaa tat ttt aaa tct cct gaa gac   435
Pro Asn Pro Pro Gly Thr Leu Cys Lys Tyr Phe Lys Ser Pro Glu Asp
                130                 135                 140
 
ttt ttg gtt aaa ttg cca gat cat gtt tca ttg gaa ttg ggt gct ttg   483
Phe Leu Val Lys Leu Pro Asp His Val Ser Leu Glu Leu Gly Ala Leu
            145                 150                 155
 
gtt gaa cca ttg tct gtt ggt gtt cat gct tct aaa ttg ggt tct gtt   531
Val Glu Pro Leu Ser Val Gly Val His Ala Ser Lys Leu Gly Ser Val
        160                 165                 170
 
gct ttt ggc gat tac gtt gct gtt ttc ggt gct ggt cca gtt ggt ttg   579
Ala Phe Gly Asp Tyr Val Ala Val Phe Gly Ala Gly Pro Val Gly Leu
    175                 180                 185
 
ttg gca gcc gca gtt gct aaa act ttt gga gct aaa ggt gta att gtt   627
Leu Ala Ala Ala Val Ala Lys Thr Phe Gly Ala Lys Gly Val Ile Val
190                 195                 200                 205
 
gtt gac att ttt gat aat aaa tta aaa atg gct aaa gat ata ggt gca   675
Val Asp Ile Phe Asp Asn Lys Leu Lys Met Ala Lys Asp Ile Gly Ala
                210                 215                 220
 
gca act cat act ttt aat tct aaa act ggt ggt tct gaa gaa ttg att   723
Ala Thr His Thr Phe Asn Ser Lys Thr Gly Gly Ser Glu Glu Leu Ile
            225                 230                 235
 
aaa gca ttt gga gga aat gtt cca aac gtt gtt tta gaa tgt act ggt   771
Lys Ala Phe Gly Gly Asn Val Pro Asn Val Val Leu Glu Cys Thr Gly
        240                 245                 250
 
gct gag cca tgt att aaa ttg ggt gtt gat gct att gct cca ggt ggt   819
Ala Glu Pro Cys Ile Lys Leu Gly Val Asp Ala Ile Ala Pro Gly Gly
    255                 260                 265
 
aga ttt gtc caa gtt ggt aat gct gct ggt cct gta tct ttt cca att   867
Arg Phe Val Gln Val Gly Asn Ala Ala Gly Pro Val Ser Phe Pro Ile
270                 275                 280                 285
 
act gtt ttt gct atg aaa gaa ttg aca ttg ttt gga tct ttt aga tat   915
Thr Val Phe Ala Met Lys Glu Leu Thr Leu Phe Gly Ser Phe Arg Tyr
                290                 295                 300
 
ggt ttt aat gat tat aaa act gct gtt gga att ttc gat act aat tat   963
Gly Phe Asn Asp Tyr Lys Thr Ala Val Gly Ile Phe Asp Thr Asn Tyr
            305                 310                 315
 
caa aat ggt aga gaa aat gct cct att gat ttt gaa caa ttg att act   1011
Gln Asn Gly Arg Glu Asn Ala Pro Ile Asp Phe Glu Gln Leu Ile Thr
        320                 325                 330
 
cat aga tat aaa ttt aaa gat gct att gag gct tat gat ttg gtt aga   1059
His Arg Tyr Lys Phe Lys Asp Ala Ile Glu Ala Tyr Asp Leu Val Arg
    335                 340                 345
 
gct ggt aaa ggt gct gtt aaa tgt ttg att gat ggt cca gaa           1101
Ala Gly Lys Gly Ala Val Lys Cys Leu Ile Asp Gly Pro Glu
350                 355                 360
 
gaattccgat g                                                      1112

<210> 60
<211> 363
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in E. coli

<400> 60
Met Thr Ala Asn Pro Ser Leu Val Leu Asn Lys Ile Asp Asp Ile Ser
 1               5                  10                  15      
Phe Glu Thr Tyr Asp Ala Pro Glu Ile Ser Glu Pro Thr Asp Val Leu
            20                  25                  30          
Val Gln Val Lys Lys Thr Gly Ile Cys Gly Ser Asp Ile His Phe Tyr
        35                  40                  45              
Ala His Gly Arg Ile Gly Asn Phe Val Leu Thr Lys Pro Met Val Leu
    50                  55                  60                  
Gly His Glu Ser Ala Gly Thr Val Val Gln Val Gly Lys Gly Val Thr
65                  70                  75                  80  
Ser Leu Lys Val Gly Asp Asn Val Ala Ile Glu Pro Gly Ile Pro Ser
                85                  90                  95      
Arg Phe Ser Asp Glu Tyr Lys Ser Gly His Tyr Asn Leu Cys Pro His
            100                 105                 110         
Met Ala Phe Ala Ala Thr Pro Asn Ser Lys Glu Gly Glu Pro Asn Pro
        115                 120                 125             
Pro Gly Thr Leu Cys Lys Tyr Phe Lys Ser Pro Glu Asp Phe Leu Val
    130                 135                 140                 
Lys Leu Pro Asp His Val Ser Leu Glu Leu Gly Ala Leu Val Glu Pro
145                 150                 155                 160 
Leu Ser Val Gly Val His Ala Ser Lys Leu Gly Ser Val Ala Phe Gly
                165                 170                 175     
Asp Tyr Val Ala Val Phe Gly Ala Gly Pro Val Gly Leu Leu Ala Ala
            180                 185                 190         
Ala Val Ala Lys Thr Phe Gly Ala Lys Gly Val Ile Val Val Asp Ile
        195                 200                 205             
Phe Asp Asn Lys Leu Lys Met Ala Lys Asp Ile Gly Ala Ala Thr His
    210                 215                 220                 
Thr Phe Asn Ser Lys Thr Gly Gly Ser Glu Glu Leu Ile Lys Ala Phe
225                 230                 235                 240 
Gly Gly Asn Val Pro Asn Val Val Leu Glu Cys Thr Gly Ala Glu Pro
                245                 250                 255     
Cys Ile Lys Leu Gly Val Asp Ala Ile Ala Pro Gly Gly Arg Phe Val
            260                 265                 270         
Gln Val Gly Asn Ala Ala Gly Pro Val Ser Phe Pro Ile Thr Val Phe
        275                 280                 285             
Ala Met Lys Glu Leu Thr Leu Phe Gly Ser Phe Arg Tyr Gly Phe Asn
    290                 295                 300                 
Asp Tyr Lys Thr Ala Val Gly Ile Phe Asp Thr Asn Tyr Gln Asn Gly
305                 310                 315                 320 
Arg Glu Asn Ala Pro Ile Asp Phe Glu Gln Leu Ile Thr His Arg Tyr
                325                 330                 335     
Lys Phe Lys Asp Ala Ile Glu Ala Tyr Asp Leu Val Arg Ala Gly Lys
            340                 345                 350         
Gly Ala Val Lys Cys Leu Ile Asp Gly Pro Glu
        355                 360             


<210> 61
<211> 1117
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in E. coli

<220> 
<221> CDS            
<222> (15)...(1103)

<400> 61
gaatactcca tatg atg act gct aat cca tct ttg gtt tta aat aaa att   50
                Met Thr Ala Asn Pro Ser Leu Val Leu Asn Lys Ile
                 1               5                   10
 
gat gac att tct ttt gaa act tat gat gct cca gaa att tca gaa cct   98
Asp Asp Ile Ser Phe Glu Thr Tyr Asp Ala Pro Glu Ile Ser Glu Pro
         15                  20                  25
 
act gat gtt ttg gta caa gtt aaa aag act gga att tgt ggt tct gac   146
Thr Asp Val Leu Val Gln Val Lys Lys Thr Gly Ile Cys Gly Ser Asp
     30                  35                  40
 
att cat ttt tat gct cat ggt aga att ggt aat ttc gtt ttg act aag   194
Ile His Phe Tyr Ala His Gly Arg Ile Gly Asn Phe Val Leu Thr Lys
 45                  50                  55                  60
 
cca atg gtt tta ggt cat gaa tct gct ggt act gtt gtt caa gtt ggt   242
Pro Met Val Leu Gly His Glu Ser Ala Gly Thr Val Val Gln Val Gly
                 65                  70                  75
 
aaa ggt gtt act tct tta aaa gta ggt gat aat gtt gct att gaa cca   290
Lys Gly Val Thr Ser Leu Lys Val Gly Asp Asn Val Ala Ile Glu Pro
             80                  85                  90
 
gga ata cca tct aga ttt tct gat gaa tat aaa tct ggt cat tat aat   338
Gly Ile Pro Ser Arg Phe Ser Asp Glu Tyr Lys Ser Gly His Tyr Asn
         95                 100                 105
 
ttg tgt cca cac atg gct ttt gct gct acc cca aat tct aaa gaa ggt   386
Leu Cys Pro His Met Ala Phe Ala Ala Thr Pro Asn Ser Lys Glu Gly
    110                 115                 120
 
gaa cca aat cca cca ggt aca ttg tgt aaa tat ttt aaa tct cct gaa   434
Glu Pro Asn Pro Pro Gly Thr Leu Cys Lys Tyr Phe Lys Ser Pro Glu
125                 130                 135                 140
 
gac ttt ttg gtt aaa ttg cca gat cat gtt tca ttg gaa ttg ggt gct   482
Asp Phe Leu Val Lys Leu Pro Asp His Val Ser Leu Glu Leu Gly Ala
                145                 150                 155
 
ttg gtt gaa cca ttg tct gtt ggt gtt cat gct tct aaa ttg ggt tct   530
Leu Val Glu Pro Leu Ser Val Gly Val His Ala Ser Lys Leu Gly Ser
            160                 165                 170
 
gtt gct ttt ggc gat tac gtt gct gtt ttc ggt gct ggt cca gtt ggt   578
Val Ala Phe Gly Asp Tyr Val Ala Val Phe Gly Ala Gly Pro Val Gly
        175                 180                 185
 
ttg ttg gca gcc gca gtt gct aaa act ttt gga gct aaa ggt gta att   626
Leu Leu Ala Ala Ala Val Ala Lys Thr Phe Gly Ala Lys Gly Val Ile
    190                 195                 200
 
gtt gtt gac att ttt gat aat aaa tta aaa atg gct aaa gat ata ggt   674
Val Val Asp Ile Phe Asp Asn Lys Leu Lys Met Ala Lys Asp Ile Gly
205                 210                 215                 220
 
gca gca act cat act ttt aat tct aaa act ggt ggt tct gaa gaa ttg   722
Ala Ala Thr His Thr Phe Asn Ser Lys Thr Gly Gly Ser Glu Glu Leu
                225                 230                 235
 
att aaa gca ttt gga gga aat gtt cca aac gtt gtt tta gaa tgt act   770
Ile Lys Ala Phe Gly Gly Asn Val Pro Asn Val Val Leu Glu Cys Thr
            240                 245                 250
 
ggt gct gag cca tgt att aaa ttg ggt gtt gat gct att gct cca ggt   818
Gly Ala Glu Pro Cys Ile Lys Leu Gly Val Asp Ala Ile Ala Pro Gly
        255                 260                 265
 
ggt aga ttt gtc caa gtt ggt aat gct gct ggt cct gta tct ttt cca   866
Gly Arg Phe Val Gln Val Gly Asn Ala Ala Gly Pro Val Ser Phe Pro
    270                 275                 280
 
att act gtt ttt gct atg aaa gaa ttg aca ttg ttt gga tct ttt aga   914
Ile Thr Val Phe Ala Met Lys Glu Leu Thr Leu Phe Gly Ser Phe Arg
285                 290                 295                 300
 
tat ggt ttt aat gat tat aaa act gct gtt gga att ttc gat act aat   962
Tyr Gly Phe Asn Asp Tyr Lys Thr Ala Val Gly Ile Phe Asp Thr Asn
                305                 310                 315
 
tat caa aat ggt aga gaa aat gct cct att gat ttt gaa caa ttg att   1010
Tyr Gln Asn Gly Arg Glu Asn Ala Pro Ile Asp Phe Glu Gln Leu Ile
            320                 325                 330
 
act cat aga tat aaa ttt aaa gat gct att gag gct tat gat ttg gtt   1058
Thr His Arg Tyr Lys Phe Lys Asp Ala Ile Glu Ala Tyr Asp Leu Val
        335                 340                 345
 
aga gct ggt aaa ggt gct gtt aaa tgt ttg att gat ggt cca gaa       1103
Arg Ala Gly Lys Gly Ala Val Lys Cys Leu Ile Asp Gly Pro Glu
    350                 355                 360
 
actagtcgat gcct                                                   1117

<210> 62
<211> 363
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in E. coli

<400> 62
Met Thr Ala Asn Pro Ser Leu Val Leu Asn Lys Ile Asp Asp Ile Ser
 1               5                  10                  15      
Phe Glu Thr Tyr Asp Ala Pro Glu Ile Ser Glu Pro Thr Asp Val Leu
            20                  25                  30          
Val Gln Val Lys Lys Thr Gly Ile Cys Gly Ser Asp Ile His Phe Tyr
        35                  40                  45              
Ala His Gly Arg Ile Gly Asn Phe Val Leu Thr Lys Pro Met Val Leu
    50                  55                  60                  
Gly His Glu Ser Ala Gly Thr Val Val Gln Val Gly Lys Gly Val Thr
65                  70                  75                  80  
Ser Leu Lys Val Gly Asp Asn Val Ala Ile Glu Pro Gly Ile Pro Ser
                85                  90                  95      
Arg Phe Ser Asp Glu Tyr Lys Ser Gly His Tyr Asn Leu Cys Pro His
            100                 105                 110         
Met Ala Phe Ala Ala Thr Pro Asn Ser Lys Glu Gly Glu Pro Asn Pro
        115                 120                 125             
Pro Gly Thr Leu Cys Lys Tyr Phe Lys Ser Pro Glu Asp Phe Leu Val
    130                 135                 140                 
Lys Leu Pro Asp His Val Ser Leu Glu Leu Gly Ala Leu Val Glu Pro
145                 150                 155                 160 
Leu Ser Val Gly Val His Ala Ser Lys Leu Gly Ser Val Ala Phe Gly
                165                 170                 175     
Asp Tyr Val Ala Val Phe Gly Ala Gly Pro Val Gly Leu Leu Ala Ala
            180                 185                 190         
Ala Val Ala Lys Thr Phe Gly Ala Lys Gly Val Ile Val Val Asp Ile
        195                 200                 205             
Phe Asp Asn Lys Leu Lys Met Ala Lys Asp Ile Gly Ala Ala Thr His
    210                 215                 220                 
Thr Phe Asn Ser Lys Thr Gly Gly Ser Glu Glu Leu Ile Lys Ala Phe
225                 230                 235                 240 
Gly Gly Asn Val Pro Asn Val Val Leu Glu Cys Thr Gly Ala Glu Pro
                245                 250                 255     
Cys Ile Lys Leu Gly Val Asp Ala Ile Ala Pro Gly Gly Arg Phe Val
            260                 265                 270         
Gln Val Gly Asn Ala Ala Gly Pro Val Ser Phe Pro Ile Thr Val Phe
        275                 280                 285             
Ala Met Lys Glu Leu Thr Leu Phe Gly Ser Phe Arg Tyr Gly Phe Asn
    290                 295                 300                 
Asp Tyr Lys Thr Ala Val Gly Ile Phe Asp Thr Asn Tyr Gln Asn Gly
305                 310                 315                 320 
Arg Glu Asn Ala Pro Ile Asp Phe Glu Gln Leu Ile Thr His Arg Tyr
                325                 330                 335     
Lys Phe Lys Asp Ala Ile Glu Ala Tyr Asp Leu Val Arg Ala Gly Lys
            340                 345                 350         
Gly Ala Val Lys Cys Leu Ile Asp Gly Pro Glu
        355                 360             


<210> 63
<211> 1089
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in P. pastoris

<220> 
<221> CDS            
<222> (1)...(1089)

<400> 63
atg act gct aat cca tct tta gtt tta aat aaa att gat gac att tct   48
Met Thr Ala Asn Pro Ser Leu Val Leu Asn Lys Ile Asp Asp Ile Ser
 1               5                   10                  15
 
ttt gag act tat gac gct cct gaa att tct gaa cca act gat gtt tta   96
Phe Glu Thr Tyr Asp Ala Pro Glu Ile Ser Glu Pro Thr Asp Val Leu
             20                  25                  30
 
gtt caa gtt aaa aag act gga att tgt gga tct gac att cat ttt tat   144
Val Gln Val Lys Lys Thr Gly Ile Cys Gly Ser Asp Ile His Phe Tyr
         35                  40                  45
 
gct cat ggt aga att gga aat ttt gtt ttg act aag cca atg gtt tta   192
Ala His Gly Arg Ile Gly Asn Phe Val Leu Thr Lys Pro Met Val Leu
     50                  55                  60
 
gga cat gaa tct gct ggt act gtt gtg caa gtt gga aaa gga gtt act   240
Gly His Glu Ser Ala Gly Thr Val Val Gln Val Gly Lys Gly Val Thr
 65                  70                  75                  80
 
tct tta aaa gtt gga gat aat gtt gct att gaa cca gga atc cca tct   288
Ser Leu Lys Val Gly Asp Asn Val Ala Ile Glu Pro Gly Ile Pro Ser
                 85                  90                  95
 
aga ttt tct gat gaa tat aaa tct ggt cat tat aat tta tgt cca cac   336
Arg Phe Ser Asp Glu Tyr Lys Ser Gly His Tyr Asn Leu Cys Pro His
            100                 105                 110
 
atg gct ttc gct gct aca cca aat tca aaa gaa gga gaa cca aac cca   384
Met Ala Phe Ala Ala Thr Pro Asn Ser Lys Glu Gly Glu Pro Asn Pro
        115                 120                 125
 
cct gga aca ttg tgt aaa tat ttt aaa tct cca gaa gac ttt ttg gtt   432
Pro Gly Thr Leu Cys Lys Tyr Phe Lys Ser Pro Glu Asp Phe Leu Val
    130                 135                 140
 
aaa ttg cca gat cat gtt tct tta gaa ttg ggt gct ttg gtt gaa cca   480
Lys Leu Pro Asp His Val Ser Leu Glu Leu Gly Ala Leu Val Glu Pro
145                 150                 155                 160
 
ttg tct gtt gga gtt cat gct tct aaa ttg gga tca gtt gct ttt ggt   528
Leu Ser Val Gly Val His Ala Ser Lys Leu Gly Ser Val Ala Phe Gly
                165                 170                 175
 
gat tat gtt gct gtt ttt ggc gct gga ccc gtt gga ttg ttg gcc gct   576
Asp Tyr Val Ala Val Phe Gly Ala Gly Pro Val Gly Leu Leu Ala Ala
            180                 185                 190
 
gct gtt gct aaa act ttc ggt gct aaa gga gtt att gtt gtt gac att   624
Ala Val Ala Lys Thr Phe Gly Ala Lys Gly Val Ile Val Val Asp Ile
        195                 200                 205
 
ttt gat aat aag tta aaa atg gct aaa gat ata gga gca gct act cat   672
Phe Asp Asn Lys Leu Lys Met Ala Lys Asp Ile Gly Ala Ala Thr His
    210                 215                 220
 
act ttt aat tct aaa act gga gga tct gaa gaa ttg att aaa gca ttc   720
Thr Phe Asn Ser Lys Thr Gly Gly Ser Glu Glu Leu Ile Lys Ala Phe
225                 230                 235                 240
 
gga gga aat gtt cca aat gtt gtt tta gaa tgt act gga gct gaa cca   768
Gly Gly Asn Val Pro Asn Val Val Leu Glu Cys Thr Gly Ala Glu Pro
                245                 250                 255
 
tgt att aaa ttg gga gtt gat gct att gcc cca gga ggt aga ttt gtt   816
Cys Ile Lys Leu Gly Val Asp Ala Ile Ala Pro Gly Gly Arg Phe Val
            260                 265                 270
 
caa gtt gga aat gca gct ggt cca gtg tct ttt cca att act gtt ttc   864
Gln Val Gly Asn Ala Ala Gly Pro Val Ser Phe Pro Ile Thr Val Phe
        275                 280                 285
 
gct atg aaa gaa ttg aca ttg ttt ggt tct ttt aga tat gga ttt aat   912
Ala Met Lys Glu Leu Thr Leu Phe Gly Ser Phe Arg Tyr Gly Phe Asn
    290                 295                 300
 
gat tat aaa act gct gtg gga att ttc gat act aat tat caa aat ggt   960
Asp Tyr Lys Thr Ala Val Gly Ile Phe Asp Thr Asn Tyr Gln Asn Gly
305                 310                 315                 320
 
aga gaa aat gca cct att gat ttt gag caa ttg att act cat aga tat   1008
Arg Glu Asn Ala Pro Ile Asp Phe Glu Gln Leu Ile Thr His Arg Tyr
                325                 330                 335
 
aaa ttt aaa gat gct att gag gct tat gat ttg gtt aga gct gga aaa   1056
Lys Phe Lys Asp Ala Ile Glu Ala Tyr Asp Leu Val Arg Ala Gly Lys
            340                 345                 350
 
gga gct gtt aaa tgt ttg att gat gga cca gaa                       1089
Gly Ala Val Lys Cys Leu Ile Asp Gly Pro Glu
        355                 360
 

<210> 64
<211> 363
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in P. pastoris

<400> 64
Met Thr Ala Asn Pro Ser Leu Val Leu Asn Lys Ile Asp Asp Ile Ser
 1               5                  10                  15      
Phe Glu Thr Tyr Asp Ala Pro Glu Ile Ser Glu Pro Thr Asp Val Leu
            20                  25                  30          
Val Gln Val Lys Lys Thr Gly Ile Cys Gly Ser Asp Ile His Phe Tyr
        35                  40                  45              
Ala His Gly Arg Ile Gly Asn Phe Val Leu Thr Lys Pro Met Val Leu
    50                  55                  60                  
Gly His Glu Ser Ala Gly Thr Val Val Gln Val Gly Lys Gly Val Thr
65                  70                  75                  80  
Ser Leu Lys Val Gly Asp Asn Val Ala Ile Glu Pro Gly Ile Pro Ser
                85                  90                  95      
Arg Phe Ser Asp Glu Tyr Lys Ser Gly His Tyr Asn Leu Cys Pro His
            100                 105                 110         
Met Ala Phe Ala Ala Thr Pro Asn Ser Lys Glu Gly Glu Pro Asn Pro
        115                 120                 125             
Pro Gly Thr Leu Cys Lys Tyr Phe Lys Ser Pro Glu Asp Phe Leu Val
    130                 135                 140                 
Lys Leu Pro Asp His Val Ser Leu Glu Leu Gly Ala Leu Val Glu Pro
145                 150                 155                 160 
Leu Ser Val Gly Val His Ala Ser Lys Leu Gly Ser Val Ala Phe Gly
                165                 170                 175     
Asp Tyr Val Ala Val Phe Gly Ala Gly Pro Val Gly Leu Leu Ala Ala
            180                 185                 190         
Ala Val Ala Lys Thr Phe Gly Ala Lys Gly Val Ile Val Val Asp Ile
        195                 200                 205             
Phe Asp Asn Lys Leu Lys Met Ala Lys Asp Ile Gly Ala Ala Thr His
    210                 215                 220                 
Thr Phe Asn Ser Lys Thr Gly Gly Ser Glu Glu Leu Ile Lys Ala Phe
225                 230                 235                 240 
Gly Gly Asn Val Pro Asn Val Val Leu Glu Cys Thr Gly Ala Glu Pro
                245                 250                 255     
Cys Ile Lys Leu Gly Val Asp Ala Ile Ala Pro Gly Gly Arg Phe Val
            260                 265                 270         
Gln Val Gly Asn Ala Ala Gly Pro Val Ser Phe Pro Ile Thr Val Phe
        275                 280                 285             
Ala Met Lys Glu Leu Thr Leu Phe Gly Ser Phe Arg Tyr Gly Phe Asn
    290                 295                 300                 
Asp Tyr Lys Thr Ala Val Gly Ile Phe Asp Thr Asn Tyr Gln Asn Gly
305                 310                 315                 320 
Arg Glu Asn Ala Pro Ile Asp Phe Glu Gln Leu Ile Thr His Arg Tyr
                325                 330                 335     
Lys Phe Lys Asp Ala Ile Glu Ala Tyr Asp Leu Val Arg Ala Gly Lys
            340                 345                 350         
Gly Ala Val Lys Cys Leu Ile Asp Gly Pro Glu
        355                 360             


<210> 65
<211> 1117
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in P. pastoris

<220> 
<221> CDS            
<222> (15)...(1103)

<400> 65
gaatactcca tatg atg act gct aat cca tct tta gtt tta aat aaa att   50
                Met Thr Ala Asn Pro Ser Leu Val Leu Asn Lys Ile
                 1               5                   10
 
gat gac att tct ttt gag act tat gac gct cct gaa att tct gaa cca   98
Asp Asp Ile Ser Phe Glu Thr Tyr Asp Ala Pro Glu Ile Ser Glu Pro
         15                  20                  25
 
act gat gtt tta gtt caa gtt aaa aag act gga att tgt gga tct gac   146
Thr Asp Val Leu Val Gln Val Lys Lys Thr Gly Ile Cys Gly Ser Asp
     30                  35                  40
 
att cat ttt tat gct cat ggt aga att gga aat ttt gtt ttg act aag   194
Ile His Phe Tyr Ala His Gly Arg Ile Gly Asn Phe Val Leu Thr Lys
 45                  50                  55                  60
 
cca atg gtt tta gga cat gaa tct gct ggt act gtt gtg caa gtt gga   242
Pro Met Val Leu Gly His Glu Ser Ala Gly Thr Val Val Gln Val Gly
                 65                  70                  75
 
aaa gga gtt act tct tta aaa gtt gga gat aat gtt gct att gaa cca   290
Lys Gly Val Thr Ser Leu Lys Val Gly Asp Asn Val Ala Ile Glu Pro
             80                  85                  90
 
gga atc cca tct aga ttt tct gat gaa tat aaa tct ggt cat tat aat   338
Gly Ile Pro Ser Arg Phe Ser Asp Glu Tyr Lys Ser Gly His Tyr Asn
         95                 100                 105
 
tta tgt cca cac atg gct ttc gct gct aca cca aat tca aaa gaa gga   386
Leu Cys Pro His Met Ala Phe Ala Ala Thr Pro Asn Ser Lys Glu Gly
    110                 115                 120
 
gaa cca aac cca cct gga aca ttg tgt aaa tat ttt aaa tct cca gaa   434
Glu Pro Asn Pro Pro Gly Thr Leu Cys Lys Tyr Phe Lys Ser Pro Glu
125                 130                 135                 140
 
gac ttt ttg gtt aaa ttg cca gat cat gtt tct tta gaa ttg ggt gct   482
Asp Phe Leu Val Lys Leu Pro Asp His Val Ser Leu Glu Leu Gly Ala
                145                 150                 155
 
ttg gtt gaa cca ttg tct gtt gga gtt cat gct tct aaa ttg gga tca   530
Leu Val Glu Pro Leu Ser Val Gly Val His Ala Ser Lys Leu Gly Ser
            160                 165                 170
 
gtt gct ttt ggt gat tat gtt gct gtt ttt ggc gct gga ccc gtt gga   578
Val Ala Phe Gly Asp Tyr Val Ala Val Phe Gly Ala Gly Pro Val Gly
        175                 180                 185
 
ttg ttg gcc gct gct gtt gct aaa act ttc ggt gct aaa gga gtt att   626
Leu Leu Ala Ala Ala Val Ala Lys Thr Phe Gly Ala Lys Gly Val Ile
    190                 195                 200
 
gtt gtt gac att ttt gat aat aag tta aaa atg gct aaa gat ata gga   674
Val Val Asp Ile Phe Asp Asn Lys Leu Lys Met Ala Lys Asp Ile Gly
205                 210                 215                 220
 
gca gct act cat act ttt aat tct aaa act gga gga tct gaa gaa ttg   722
Ala Ala Thr His Thr Phe Asn Ser Lys Thr Gly Gly Ser Glu Glu Leu
                225                 230                 235
 
att aaa gca ttc gga gga aat gtt cca aat gtt gtt tta gaa tgt act   770
Ile Lys Ala Phe Gly Gly Asn Val Pro Asn Val Val Leu Glu Cys Thr
            240                 245                 250
 
gga gct gaa cca tgt att aaa ttg gga gtt gat gct att gcc cca gga   818
Gly Ala Glu Pro Cys Ile Lys Leu Gly Val Asp Ala Ile Ala Pro Gly
        255                 260                 265
 
ggt aga ttt gtt caa gtt gga aat gca gct ggt cca gtg tct ttt cca   866
Gly Arg Phe Val Gln Val Gly Asn Ala Ala Gly Pro Val Ser Phe Pro
    270                 275                 280
 
att act gtt ttc gct atg aaa gaa ttg aca ttg ttt ggt tct ttt aga   914
Ile Thr Val Phe Ala Met Lys Glu Leu Thr Leu Phe Gly Ser Phe Arg
285                 290                 295                 300
 
tat gga ttt aat gat tat aaa act gct gtg gga att ttc gat act aat   962
Tyr Gly Phe Asn Asp Tyr Lys Thr Ala Val Gly Ile Phe Asp Thr Asn
                305                 310                 315
 
tat caa aat ggt aga gaa aat gca cct att gat ttt gag caa ttg att   1010
Tyr Gln Asn Gly Arg Glu Asn Ala Pro Ile Asp Phe Glu Gln Leu Ile
            320                 325                 330
 
act cat aga tat aaa ttt aaa gat gct att gag gct tat gat ttg gtt   1058
Thr His Arg Tyr Lys Phe Lys Asp Ala Ile Glu Ala Tyr Asp Leu Val
        335                 340                 345
 
aga gct gga aaa gga gct gtt aaa tgt ttg att gat gga cca gaa       1103
Arg Ala Gly Lys Gly Ala Val Lys Cys Leu Ile Asp Gly Pro Glu
    350                 355                 360
 
actagtcgat gcct                                                   1117

<210> 66
<211> 363
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in P. pastoris

<400> 66
Met Thr Ala Asn Pro Ser Leu Val Leu Asn Lys Ile Asp Asp Ile Ser
 1               5                  10                  15      
Phe Glu Thr Tyr Asp Ala Pro Glu Ile Ser Glu Pro Thr Asp Val Leu
            20                  25                  30          
Val Gln Val Lys Lys Thr Gly Ile Cys Gly Ser Asp Ile His Phe Tyr
        35                  40                  45              
Ala His Gly Arg Ile Gly Asn Phe Val Leu Thr Lys Pro Met Val Leu
    50                  55                  60                  
Gly His Glu Ser Ala Gly Thr Val Val Gln Val Gly Lys Gly Val Thr
65                  70                  75                  80  
Ser Leu Lys Val Gly Asp Asn Val Ala Ile Glu Pro Gly Ile Pro Ser
                85                  90                  95      
Arg Phe Ser Asp Glu Tyr Lys Ser Gly His Tyr Asn Leu Cys Pro His
            100                 105                 110         
Met Ala Phe Ala Ala Thr Pro Asn Ser Lys Glu Gly Glu Pro Asn Pro
        115                 120                 125             
Pro Gly Thr Leu Cys Lys Tyr Phe Lys Ser Pro Glu Asp Phe Leu Val
    130                 135                 140                 
Lys Leu Pro Asp His Val Ser Leu Glu Leu Gly Ala Leu Val Glu Pro
145                 150                 155                 160 
Leu Ser Val Gly Val His Ala Ser Lys Leu Gly Ser Val Ala Phe Gly
                165                 170                 175     
Asp Tyr Val Ala Val Phe Gly Ala Gly Pro Val Gly Leu Leu Ala Ala
            180                 185                 190         
Ala Val Ala Lys Thr Phe Gly Ala Lys Gly Val Ile Val Val Asp Ile
        195                 200                 205             
Phe Asp Asn Lys Leu Lys Met Ala Lys Asp Ile Gly Ala Ala Thr His
    210                 215                 220                 
Thr Phe Asn Ser Lys Thr Gly Gly Ser Glu Glu Leu Ile Lys Ala Phe
225                 230                 235                 240 
Gly Gly Asn Val Pro Asn Val Val Leu Glu Cys Thr Gly Ala Glu Pro
                245                 250                 255     
Cys Ile Lys Leu Gly Val Asp Ala Ile Ala Pro Gly Gly Arg Phe Val
            260                 265                 270         
Gln Val Gly Asn Ala Ala Gly Pro Val Ser Phe Pro Ile Thr Val Phe
        275                 280                 285             
Ala Met Lys Glu Leu Thr Leu Phe Gly Ser Phe Arg Tyr Gly Phe Asn
    290                 295                 300                 
Asp Tyr Lys Thr Ala Val Gly Ile Phe Asp Thr Asn Tyr Gln Asn Gly
305                 310                 315                 320 
Arg Glu Asn Ala Pro Ile Asp Phe Glu Gln Leu Ile Thr His Arg Tyr
                325                 330                 335     
Lys Phe Lys Asp Ala Ile Glu Ala Tyr Asp Leu Val Arg Ala Gly Lys
            340                 345                 350         
Gly Ala Val Lys Cys Leu Ile Asp Gly Pro Glu
        355                 360             


<210> 67
<211> 1111
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in P. pastoris

<220> 
<221> CDS            
<222> (12)...(1100)

<400> 67
tactcaagct t atg act gct aat cca tct tta gtt tta aat aaa att gat  50
             Met Thr Ala Asn Pro Ser Leu Val Leu Asn Lys Ile Asp
              1               5                   10
 
gac att tct ttt gag act tat gac gct cct gaa att tct gaa cca act   98
Asp Ile Ser Phe Glu Thr Tyr Asp Ala Pro Glu Ile Ser Glu Pro Thr
     15                  20                  25
 
gat gtt tta gtt caa gtt aaa aag act gga att tgt gga tct gac att   146
Asp Val Leu Val Gln Val Lys Lys Thr Gly Ile Cys Gly Ser Asp Ile
 30                  35                  40                  45
 
cat ttt tat gct cat ggt aga att gga aat ttt gtt ttg act aag cca   194
His Phe Tyr Ala His Gly Arg Ile Gly Asn Phe Val Leu Thr Lys Pro
                 50                  55                  60
 
atg gtt tta gga cat gaa tct gct ggt act gtt gtg caa gtt gga aaa   242
Met Val Leu Gly His Glu Ser Ala Gly Thr Val Val Gln Val Gly Lys
             65                  70                  75
 
gga gtt act tct tta aaa gtt gga gat aat gtt gct att gaa cca gga   290
Gly Val Thr Ser Leu Lys Val Gly Asp Asn Val Ala Ile Glu Pro Gly
         80                  85                  90
 
atc cca tct aga ttt tct gat gaa tat aaa tct ggt cat tat aat tta   338
Ile Pro Ser Arg Phe Ser Asp Glu Tyr Lys Ser Gly His Tyr Asn Leu
     95                 100                 105
 
tgt cca cac atg gct ttc gct gct aca cca aat tca aaa gaa gga gaa   386
Cys Pro His Met Ala Phe Ala Ala Thr Pro Asn Ser Lys Glu Gly Glu
110                 115                 120                 125
 
cca aac cca cct gga aca ttg tgt aaa tat ttt aaa tct cca gaa gac   434
Pro Asn Pro Pro Gly Thr Leu Cys Lys Tyr Phe Lys Ser Pro Glu Asp
                130                 135                 140
 
ttt ttg gtt aaa ttg cca gat cat gtt tct tta gaa ttg ggt gct ttg   482
Phe Leu Val Lys Leu Pro Asp His Val Ser Leu Glu Leu Gly Ala Leu
            145                 150                 155
 
gtt gaa cca ttg tct gtt gga gtt cat gct tct aaa ttg gga tca gtt   530
Val Glu Pro Leu Ser Val Gly Val His Ala Ser Lys Leu Gly Ser Val
        160                 165                 170
 
gct ttt ggt gat tat gtt gct gtt ttt ggc gct gga ccc gtt gga ttg   578
Ala Phe Gly Asp Tyr Val Ala Val Phe Gly Ala Gly Pro Val Gly Leu
    175                 180                 185
 
ttg gcc gct gct gtt gct aaa act ttc ggt gct aaa gga gtt att gtt   626
Leu Ala Ala Ala Val Ala Lys Thr Phe Gly Ala Lys Gly Val Ile Val
190                 195                 200                 205
 
gtt gac att ttt gat aat aag tta aaa atg gct aaa gat ata gga gca   674
Val Asp Ile Phe Asp Asn Lys Leu Lys Met Ala Lys Asp Ile Gly Ala
                210                 215                 220
 
gct act cat act ttt aat tct aaa act gga gga tct gaa gaa ttg att   722
Ala Thr His Thr Phe Asn Ser Lys Thr Gly Gly Ser Glu Glu Leu Ile
            225                 230                 235
 
aaa gca ttc gga gga aat gtt cca aat gtt gtt tta gaa tgt act gga   770
Lys Ala Phe Gly Gly Asn Val Pro Asn Val Val Leu Glu Cys Thr Gly
        240                 245                 250
 
gct gaa cca tgt att aaa ttg gga gtt gat gct att gcc cca gga ggt   818
Ala Glu Pro Cys Ile Lys Leu Gly Val Asp Ala Ile Ala Pro Gly Gly
    255                 260                 265
 
aga ttt gtt caa gtt gga aat gca gct ggt cca gtg tct ttt cca att   866
Arg Phe Val Gln Val Gly Asn Ala Ala Gly Pro Val Ser Phe Pro Ile
270                 275                 280                 285
 
act gtt ttc gct atg aaa gaa ttg aca ttg ttt ggt tct ttt aga tat   914
Thr Val Phe Ala Met Lys Glu Leu Thr Leu Phe Gly Ser Phe Arg Tyr
                290                 295                 300
 
gga ttt aat gat tat aaa act gct gtg gga att ttc gat act aat tat   962
Gly Phe Asn Asp Tyr Lys Thr Ala Val Gly Ile Phe Asp Thr Asn Tyr
            305                 310                 315
 
caa aat ggt aga gaa aat gca cct att gat ttt gag caa ttg att act   1010
Gln Asn Gly Arg Glu Asn Ala Pro Ile Asp Phe Glu Gln Leu Ile Thr
        320                 325                 330
 
cat aga tat aaa ttt aaa gat gct att gag gct tat gat ttg gtt aga   1058
His Arg Tyr Lys Phe Lys Asp Ala Ile Glu Ala Tyr Asp Leu Val Arg
    335                 340                 345
 
gct gga aaa gga gct gtt aaa tgt ttg att gat gga cca gaa           1100
Ala Gly Lys Gly Ala Val Lys Cys Leu Ile Asp Gly Pro Glu
350                 355                 360
 
gaattccgat g                                                      1111

<210> 68
<211> 363
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in P. pastoris

<400> 68
Met Thr Ala Asn Pro Ser Leu Val Leu Asn Lys Ile Asp Asp Ile Ser
 1               5                  10                  15      
Phe Glu Thr Tyr Asp Ala Pro Glu Ile Ser Glu Pro Thr Asp Val Leu
            20                  25                  30          
Val Gln Val Lys Lys Thr Gly Ile Cys Gly Ser Asp Ile His Phe Tyr
        35                  40                  45              
Ala His Gly Arg Ile Gly Asn Phe Val Leu Thr Lys Pro Met Val Leu
    50                  55                  60                  
Gly His Glu Ser Ala Gly Thr Val Val Gln Val Gly Lys Gly Val Thr
65                  70                  75                  80  
Ser Leu Lys Val Gly Asp Asn Val Ala Ile Glu Pro Gly Ile Pro Ser
                85                  90                  95      
Arg Phe Ser Asp Glu Tyr Lys Ser Gly His Tyr Asn Leu Cys Pro His
            100                 105                 110         
Met Ala Phe Ala Ala Thr Pro Asn Ser Lys Glu Gly Glu Pro Asn Pro
        115                 120                 125             
Pro Gly Thr Leu Cys Lys Tyr Phe Lys Ser Pro Glu Asp Phe Leu Val
    130                 135                 140                 
Lys Leu Pro Asp His Val Ser Leu Glu Leu Gly Ala Leu Val Glu Pro
145                 150                 155                 160 
Leu Ser Val Gly Val His Ala Ser Lys Leu Gly Ser Val Ala Phe Gly
                165                 170                 175     
Asp Tyr Val Ala Val Phe Gly Ala Gly Pro Val Gly Leu Leu Ala Ala
            180                 185                 190         
Ala Val Ala Lys Thr Phe Gly Ala Lys Gly Val Ile Val Val Asp Ile
        195                 200                 205             
Phe Asp Asn Lys Leu Lys Met Ala Lys Asp Ile Gly Ala Ala Thr His
    210                 215                 220                 
Thr Phe Asn Ser Lys Thr Gly Gly Ser Glu Glu Leu Ile Lys Ala Phe
225                 230                 235                 240 
Gly Gly Asn Val Pro Asn Val Val Leu Glu Cys Thr Gly Ala Glu Pro
                245                 250                 255     
Cys Ile Lys Leu Gly Val Asp Ala Ile Ala Pro Gly Gly Arg Phe Val
            260                 265                 270         
Gln Val Gly Asn Ala Ala Gly Pro Val Ser Phe Pro Ile Thr Val Phe
        275                 280                 285             
Ala Met Lys Glu Leu Thr Leu Phe Gly Ser Phe Arg Tyr Gly Phe Asn
    290                 295                 300                 
Asp Tyr Lys Thr Ala Val Gly Ile Phe Asp Thr Asn Tyr Gln Asn Gly
305                 310                 315                 320 
Arg Glu Asn Ala Pro Ile Asp Phe Glu Gln Leu Ile Thr His Arg Tyr
                325                 330                 335     
Lys Phe Lys Asp Ala Ile Glu Ala Tyr Asp Leu Val Arg Ala Gly Lys
            340                 345                 350         
Gly Ala Val Lys Cys Leu Ile Asp Gly Pro Glu
        355                 360             


<210> 69
<211> 1089
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in K. lactis

<220> 
<221> CDS            
<222> (1)...(1089)

<400> 69
atg act gct aat cca tca ttg gtg tta aat aaa att gat gac att tct   48
Met Thr Ala Asn Pro Ser Leu Val Leu Asn Lys Ile Asp Asp Ile Ser
 1               5                   10                  15
 
ttc gaa act tat gat gct cca gaa att tca gaa cca act gat gtt ttg   96
Phe Glu Thr Tyr Asp Ala Pro Glu Ile Ser Glu Pro Thr Asp Val Leu
             20                  25                  30
 
gtt caa gtt aaa aag act gga atc tgt ggt tct gac att cac ttc tat   144
Val Gln Val Lys Lys Thr Gly Ile Cys Gly Ser Asp Ile His Phe Tyr
         35                  40                  45
 
gct cat ggt aga att ggt aat ttc gtt ttg act aaa cca atg gtt ttg   192
Ala His Gly Arg Ile Gly Asn Phe Val Leu Thr Lys Pro Met Val Leu
     50                  55                  60
 
ggt cat gaa tct gct gga act gtt gtt caa gtt gga aaa ggt gtt act   240
Gly His Glu Ser Ala Gly Thr Val Val Gln Val Gly Lys Gly Val Thr
 65                  70                  75                  80
 
tca tta aag gtt ggt gat aat gtt gct att gaa cca ggt ata cca agt   288
Ser Leu Lys Val Gly Asp Asn Val Ala Ile Glu Pro Gly Ile Pro Ser
                 85                  90                  95
 
aga ttc tct gat gaa tat aaa tct ggt cat tat aat ttg tgt cca cac   336
Arg Phe Ser Asp Glu Tyr Lys Ser Gly His Tyr Asn Leu Cys Pro His
            100                 105                 110
 
atg gct ttc gct gct act cca aat tct aaa gaa ggt gaa cca aat cca   384
Met Ala Phe Ala Ala Thr Pro Asn Ser Lys Glu Gly Glu Pro Asn Pro
        115                 120                 125
 
cca ggt aca ttg tgt aaa tac ttc aaa tca cca gaa gat ttc ttg gtt   432
Pro Gly Thr Leu Cys Lys Tyr Phe Lys Ser Pro Glu Asp Phe Leu Val
    130                 135                 140
 
aaa ttg cca gat cat gtt tca ttg gaa ttg ggt gct ttg gtt gaa cca   480
Lys Leu Pro Asp His Val Ser Leu Glu Leu Gly Ala Leu Val Glu Pro
145                 150                 155                 160
 
ttg tct gtt ggt gtt cat gct tct aaa ttg ggt tct gtt gct ttc gga   528
Leu Ser Val Gly Val His Ala Ser Lys Leu Gly Ser Val Ala Phe Gly
                165                 170                 175
 
gat tat gtc gcc gtt ttc ggt gca ggg cca gtt ggt ctc ttg gct gct   576
Asp Tyr Val Ala Val Phe Gly Ala Gly Pro Val Gly Leu Leu Ala Ala
            180                 185                 190
 
gca gtt gct aaa act ttc ggg gcg aaa ggt gtt att gtt gtt gac att   624
Ala Val Ala Lys Thr Phe Gly Ala Lys Gly Val Ile Val Val Asp Ile
        195                 200                 205
 
ttc gat aat aaa tta aag atg gct aaa gac att ggt gct gcg aca cat   672
Phe Asp Asn Lys Leu Lys Met Ala Lys Asp Ile Gly Ala Ala Thr His
    210                 215                 220
 
act ttc aat tct aaa act ggt ggt agc gaa gaa ttg att aaa gca ttc   720
Thr Phe Asn Ser Lys Thr Gly Gly Ser Glu Glu Leu Ile Lys Ala Phe
225                 230                 235                 240
 
ggt ggt aat gtt cca aat gtt gtt tta gaa tgt act ggt gcg gaa cca   768
Gly Gly Asn Val Pro Asn Val Val Leu Glu Cys Thr Gly Ala Glu Pro
                245                 250                 255
 
tgt att aaa ttg ggc gtt gat gca atc gct cct gga ggt aga ttc gtt   816
Cys Ile Lys Leu Gly Val Asp Ala Ile Ala Pro Gly Gly Arg Phe Val
            260                 265                 270
 
cag gtg ggt aat gct gcc ggt cct gtc tct ttc cct att act gtt ttc   864
Gln Val Gly Asn Ala Ala Gly Pro Val Ser Phe Pro Ile Thr Val Phe
        275                 280                 285
 
gct atg aaa gaa ttg aca ttg ttc ggt tct ttc aga tat ggt ttc aat   912
Ala Met Lys Glu Leu Thr Leu Phe Gly Ser Phe Arg Tyr Gly Phe Asn
    290                 295                 300
 
gat tat aaa act gct gtt gga ata ttc gat act aat tat caa aat ggt   960
Asp Tyr Lys Thr Ala Val Gly Ile Phe Asp Thr Asn Tyr Gln Asn Gly
305                 310                 315                 320
 
aga gaa aat gct cct att gat ttc gaa caa ttg att act cat aga tat   1008
Arg Glu Asn Ala Pro Ile Asp Phe Glu Gln Leu Ile Thr His Arg Tyr
                325                 330                 335
 
aaa ttc aaa gat gct att gag gct tat gat ttg gtt aga gct gga aaa   1056
Lys Phe Lys Asp Ala Ile Glu Ala Tyr Asp Leu Val Arg Ala Gly Lys
            340                 345                 350
 
ggg gcc gtg aag tgt ttg att gat ggt ccg gaa                       1089
Gly Ala Val Lys Cys Leu Ile Asp Gly Pro Glu
        355                 360
 

<210> 70
<211> 363
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in K. lactis

<400> 70
Met Thr Ala Asn Pro Ser Leu Val Leu Asn Lys Ile Asp Asp Ile Ser
 1               5                  10                  15      
Phe Glu Thr Tyr Asp Ala Pro Glu Ile Ser Glu Pro Thr Asp Val Leu
            20                  25                  30          
Val Gln Val Lys Lys Thr Gly Ile Cys Gly Ser Asp Ile His Phe Tyr
        35                  40                  45              
Ala His Gly Arg Ile Gly Asn Phe Val Leu Thr Lys Pro Met Val Leu
    50                  55                  60                  
Gly His Glu Ser Ala Gly Thr Val Val Gln Val Gly Lys Gly Val Thr
65                  70                  75                  80  
Ser Leu Lys Val Gly Asp Asn Val Ala Ile Glu Pro Gly Ile Pro Ser
                85                  90                  95      
Arg Phe Ser Asp Glu Tyr Lys Ser Gly His Tyr Asn Leu Cys Pro His
            100                 105                 110         
Met Ala Phe Ala Ala Thr Pro Asn Ser Lys Glu Gly Glu Pro Asn Pro
        115                 120                 125             
Pro Gly Thr Leu Cys Lys Tyr Phe Lys Ser Pro Glu Asp Phe Leu Val
    130                 135                 140                 
Lys Leu Pro Asp His Val Ser Leu Glu Leu Gly Ala Leu Val Glu Pro
145                 150                 155                 160 
Leu Ser Val Gly Val His Ala Ser Lys Leu Gly Ser Val Ala Phe Gly
                165                 170                 175     
Asp Tyr Val Ala Val Phe Gly Ala Gly Pro Val Gly Leu Leu Ala Ala
            180                 185                 190         
Ala Val Ala Lys Thr Phe Gly Ala Lys Gly Val Ile Val Val Asp Ile
        195                 200                 205             
Phe Asp Asn Lys Leu Lys Met Ala Lys Asp Ile Gly Ala Ala Thr His
    210                 215                 220                 
Thr Phe Asn Ser Lys Thr Gly Gly Ser Glu Glu Leu Ile Lys Ala Phe
225                 230                 235                 240 
Gly Gly Asn Val Pro Asn Val Val Leu Glu Cys Thr Gly Ala Glu Pro
                245                 250                 255     
Cys Ile Lys Leu Gly Val Asp Ala Ile Ala Pro Gly Gly Arg Phe Val
            260                 265                 270         
Gln Val Gly Asn Ala Ala Gly Pro Val Ser Phe Pro Ile Thr Val Phe
        275                 280                 285             
Ala Met Lys Glu Leu Thr Leu Phe Gly Ser Phe Arg Tyr Gly Phe Asn
    290                 295                 300                 
Asp Tyr Lys Thr Ala Val Gly Ile Phe Asp Thr Asn Tyr Gln Asn Gly
305                 310                 315                 320 
Arg Glu Asn Ala Pro Ile Asp Phe Glu Gln Leu Ile Thr His Arg Tyr
                325                 330                 335     
Lys Phe Lys Asp Ala Ile Glu Ala Tyr Asp Leu Val Arg Ala Gly Lys
            340                 345                 350         
Gly Ala Val Lys Cys Leu Ile Asp Gly Pro Glu
        355                 360             


<210> 71
<211> 1089
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in Z. mobilis

<220> 
<221> CDS            
<222> (1)...(1089)

<400> 71
atg acc gct aat ccg tct tta gtt ctt aac aaa atc gac gat atc tct   48
Met Thr Ala Asn Pro Ser Leu Val Leu Asn Lys Ile Asp Asp Ile Ser
 1               5                   10                  15
 
ttt gaa acc tac gat gct ccg gaa att tct gaa ccg acc gat gtt ttg   96
Phe Glu Thr Tyr Asp Ala Pro Glu Ile Ser Glu Pro Thr Asp Val Leu
             20                  25                  30
 
gtt cag gtt aaa aag acc ggc att tgt ggt tct gat atc cat ttc tat   144
Val Gln Val Lys Lys Thr Gly Ile Cys Gly Ser Asp Ile His Phe Tyr
         35                  40                  45
 
gcc cac ggt cgt att ggt aat ttt gtt ttg acc aaa ccg atg gtt ttg   192
Ala His Gly Arg Ile Gly Asn Phe Val Leu Thr Lys Pro Met Val Leu
     50                  55                  60
 
ggt cat gaa tct gct gga acc gtt gtt cag gtt ggt aaa ggt gtt acc   240
Gly His Glu Ser Ala Gly Thr Val Val Gln Val Gly Lys Gly Val Thr
 65                  70                  75                  80
 
tct ttg aaa gtt ggt gat aat gtt gcc att gaa ccg ggc att ccg tct   288
Ser Leu Lys Val Gly Asp Asn Val Ala Ile Glu Pro Gly Ile Pro Ser
                 85                  90                  95
 
cgt ttt agt gac gag tat aaa tct ggt cac tat aat ttg tgt ccg cac   336
Arg Phe Ser Asp Glu Tyr Lys Ser Gly His Tyr Asn Leu Cys Pro His
            100                 105                 110
 
atg gcc ttc gcc gcc acg ccc aat tct aaa gaa ggt gaa ccg aat ccg   384
Met Ala Phe Ala Ala Thr Pro Asn Ser Lys Glu Gly Glu Pro Asn Pro
        115                 120                 125
 
cca ggt acg ttg tgt aag tac ttt aaa tct ccg gaa gat ttc ttg gtt   432
Pro Gly Thr Leu Cys Lys Tyr Phe Lys Ser Pro Glu Asp Phe Leu Val
    130                 135                 140
 
aaa ctt ccg gac cat gtt tct ttg gaa ctt ggg gcc ctt gtt gaa ccg   480
Lys Leu Pro Asp His Val Ser Leu Glu Leu Gly Ala Leu Val Glu Pro
145                 150                 155                 160
 
ctg agt gtt ggt gtt cat gcc tct aaa ttg ggt tct gtt gct ttc ggt   528
Leu Ser Val Gly Val His Ala Ser Lys Leu Gly Ser Val Ala Phe Gly
                165                 170                 175
 
gat tat gta gct gtt ttt ggt gct ggt cca gtt ggt ttg ttg gcc gct   576
Asp Tyr Val Ala Val Phe Gly Ala Gly Pro Val Gly Leu Leu Ala Ala
            180                 185                 190
 
gct gtt gct aaa acc ttt ggt gct aag ggc gtc att gtt gtt gac att   624
Ala Val Ala Lys Thr Phe Gly Ala Lys Gly Val Ile Val Val Asp Ile
        195                 200                 205
 
ttt gat aac aaa ttg aaa atg gcc aaa gat ata ggt gcc gca aca cac   672
Phe Asp Asn Lys Leu Lys Met Ala Lys Asp Ile Gly Ala Ala Thr His
    210                 215                 220
 
acc ttt aat tct aaa acc ggt gga agc gaa gaa ttg att aaa gcg ttt   720
Thr Phe Asn Ser Lys Thr Gly Gly Ser Glu Glu Leu Ile Lys Ala Phe
225                 230                 235                 240
 
ggt ggt aat gtt ccg aat gtt gtt ttg gaa tgt acg gga gcg gaa cca   768
Gly Gly Asn Val Pro Asn Val Val Leu Glu Cys Thr Gly Ala Glu Pro
                245                 250                 255
 
tgt att aaa ttg ggt gtt gac gcc att gcc cct ggt ggt cgt ttt gtt   816
Cys Ile Lys Leu Gly Val Asp Ala Ile Ala Pro Gly Gly Arg Phe Val
            260                 265                 270
 
caa gtt ggg aat gct gct gga cct gta tct ttt ccg att acc gtt ttt   864
Gln Val Gly Asn Ala Ala Gly Pro Val Ser Phe Pro Ile Thr Val Phe
        275                 280                 285
 
gcc atg aaa gaa ttg acc ttg ttt ggt agc ttc cgc tac ggt ttt aat   912
Ala Met Lys Glu Leu Thr Leu Phe Gly Ser Phe Arg Tyr Gly Phe Asn
    290                 295                 300
 
gat tat aaa acc gca gtg ggg att ttc gat acc aac tat cag aat ggt   960
Asp Tyr Lys Thr Ala Val Gly Ile Phe Asp Thr Asn Tyr Gln Asn Gly
305                 310                 315                 320
 
cgt gaa aat gct ccc att gat ttt gaa cag ttg att acg cat cgc tac   1008
Arg Glu Asn Ala Pro Ile Asp Phe Glu Gln Leu Ile Thr His Arg Tyr
                325                 330                 335
 
aaa ttt aaa gat gcg att gag gct tat gat ttg gtt cgt gct gga aaa   1056
Lys Phe Lys Asp Ala Ile Glu Ala Tyr Asp Leu Val Arg Ala Gly Lys
            340                 345                 350
 
ggt gca gtt aaa tgt ttg att gat ggt ccc gaa                       1089
Gly Ala Val Lys Cys Leu Ile Asp Gly Pro Glu
        355                 360
 

<210> 72
<211> 363
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in Z. mobilis

<400> 72
Met Thr Ala Asn Pro Ser Leu Val Leu Asn Lys Ile Asp Asp Ile Ser
 1               5                  10                  15      
Phe Glu Thr Tyr Asp Ala Pro Glu Ile Ser Glu Pro Thr Asp Val Leu
            20                  25                  30          
Val Gln Val Lys Lys Thr Gly Ile Cys Gly Ser Asp Ile His Phe Tyr
        35                  40                  45              
Ala His Gly Arg Ile Gly Asn Phe Val Leu Thr Lys Pro Met Val Leu
    50                  55                  60                  
Gly His Glu Ser Ala Gly Thr Val Val Gln Val Gly Lys Gly Val Thr
65                  70                  75                  80  
Ser Leu Lys Val Gly Asp Asn Val Ala Ile Glu Pro Gly Ile Pro Ser
                85                  90                  95      
Arg Phe Ser Asp Glu Tyr Lys Ser Gly His Tyr Asn Leu Cys Pro His
            100                 105                 110         
Met Ala Phe Ala Ala Thr Pro Asn Ser Lys Glu Gly Glu Pro Asn Pro
        115                 120                 125             
Pro Gly Thr Leu Cys Lys Tyr Phe Lys Ser Pro Glu Asp Phe Leu Val
    130                 135                 140                 
Lys Leu Pro Asp His Val Ser Leu Glu Leu Gly Ala Leu Val Glu Pro
145                 150                 155                 160 
Leu Ser Val Gly Val His Ala Ser Lys Leu Gly Ser Val Ala Phe Gly
                165                 170                 175     
Asp Tyr Val Ala Val Phe Gly Ala Gly Pro Val Gly Leu Leu Ala Ala
            180                 185                 190         
Ala Val Ala Lys Thr Phe Gly Ala Lys Gly Val Ile Val Val Asp Ile
        195                 200                 205             
Phe Asp Asn Lys Leu Lys Met Ala Lys Asp Ile Gly Ala Ala Thr His
    210                 215                 220                 
Thr Phe Asn Ser Lys Thr Gly Gly Ser Glu Glu Leu Ile Lys Ala Phe
225                 230                 235                 240 
Gly Gly Asn Val Pro Asn Val Val Leu Glu Cys Thr Gly Ala Glu Pro
                245                 250                 255     
Cys Ile Lys Leu Gly Val Asp Ala Ile Ala Pro Gly Gly Arg Phe Val
            260                 265                 270         
Gln Val Gly Asn Ala Ala Gly Pro Val Ser Phe Pro Ile Thr Val Phe
        275                 280                 285             
Ala Met Lys Glu Leu Thr Leu Phe Gly Ser Phe Arg Tyr Gly Phe Asn
    290                 295                 300                 
Asp Tyr Lys Thr Ala Val Gly Ile Phe Asp Thr Asn Tyr Gln Asn Gly
305                 310                 315                 320 
Arg Glu Asn Ala Pro Ile Asp Phe Glu Gln Leu Ile Thr His Arg Tyr
                325                 330                 335     
Lys Phe Lys Asp Ala Ile Glu Ala Tyr Asp Leu Val Arg Ala Gly Lys
            340                 345                 350         
Gly Ala Val Lys Cys Leu Ile Asp Gly Pro Glu
        355                 360             


<210> 73
<211> 1869
<212> DNA
<213> P. stipitis

<220> 
<221> CDS            
<222> (1)...(1869)

<400> 73
atg acc act acc cca ttt gat gct cca gat aag ctc ttc ctc ggg ttc   48
Met Thr Thr Thr Pro Phe Asp Ala Pro Asp Lys Leu Phe Leu Gly Phe
 1               5                   10                  15
 
gat ctt tcg act cag cag ttg aag atc atc gtc acc gat gaa aac ctc   96
Asp Leu Ser Thr Gln Gln Leu Lys Ile Ile Val Thr Asp Glu Asn Leu
             20                  25                  30
 
gct gct ctc aaa acc tac aat gtc gag ttc gat agc atc aac agc tct   144
Ala Ala Leu Lys Thr Tyr Asn Val Glu Phe Asp Ser Ile Asn Ser Ser
         35                  40                  45
 
gtc cag aag ggt gtc att gct atc aac gac gaa atc agc aag ggt gcc   192
Val Gln Lys Gly Val Ile Ala Ile Asn Asp Glu Ile Ser Lys Gly Ala
     50                  55                  60
 
att att tcc ccc gtt tac atg tgg ttg gat gcc ctt gac cat gtt ttt   240
Ile Ile Ser Pro Val Tyr Met Trp Leu Asp Ala Leu Asp His Val Phe
 65                  70                  75                  80
 
gaa gac atg aag aag gac gga ttc ccc ttc aac aag gtt gtt ggt att   288
Glu Asp Met Lys Lys Asp Gly Phe Pro Phe Asn Lys Val Val Gly Ile
                 85                  90                  95
 
tcc ggt tct tgt caa cag cac ggt tcg gta tac tgg tct aga acg gcc   336
Ser Gly Ser Cys Gln Gln His Gly Ser Val Tyr Trp Ser Arg Thr Ala
            100                 105                 110
 
gag aag gtc ttg tcc gaa ttg gac gct gaa tct tcg tta tcg agc cag   384
Glu Lys Val Leu Ser Glu Leu Asp Ala Glu Ser Ser Leu Ser Ser Gln
        115                 120                 125
 
atg aga tct gct ttc acc ttc aag cac gct cca aac tgg cag gat cac   432
Met Arg Ser Ala Phe Thr Phe Lys His Ala Pro Asn Trp Gln Asp His
    130                 135                 140
 
tct acc ggt aaa gag ctt gaa gag ttc gaa aga gtg att ggt gct gat   480
Ser Thr Gly Lys Glu Leu Glu Glu Phe Glu Arg Val Ile Gly Ala Asp
145                 150                 155                 160
 
gcc ttg gct gat atc tct ggt tcc aga gcc cat tac aga ttc aca ggg   528
Ala Leu Ala Asp Ile Ser Gly Ser Arg Ala His Tyr Arg Phe Thr Gly
                165                 170                 175
 
ctc cag att aga aag ttg tct acc aga ttc aag ccc gaa aag tac aac   576
Leu Gln Ile Arg Lys Leu Ser Thr Arg Phe Lys Pro Glu Lys Tyr Asn
            180                 185                 190
 
aga act gct cgt atc tct tta gtt tcg tca ttt gtt gcc agt gtg ttg   624
Arg Thr Ala Arg Ile Ser Leu Val Ser Ser Phe Val Ala Ser Val Leu
        195                 200                 205
 
ctt ggt aga atc acc tcc att gaa gaa gcc gat gct tgt gga atg aac   672
Leu Gly Arg Ile Thr Ser Ile Glu Glu Ala Asp Ala Cys Gly Met Asn
    210                 215                 220
 
ttg tac gat atc gaa aag cgc gag ttc aac gaa gag ctc ttg gcc atc   720
Leu Tyr Asp Ile Glu Lys Arg Glu Phe Asn Glu Glu Leu Leu Ala Ile
225                 230                 235                 240
 
gct gct ggt gtc cac cct gag ttg gat ggt gta gaa caa gac ggt gaa   768
Ala Ala Gly Val His Pro Glu Leu Asp Gly Val Glu Gln Asp Gly Glu
                245                 250                 255
 
att tac aga gct ggt atc aat gag ttg aag aga aag ttg ggt cct gtc   816
Ile Tyr Arg Ala Gly Ile Asn Glu Leu Lys Arg Lys Leu Gly Pro Val
            260                 265                 270
 
aaa cct ata aca tac gaa agc gaa ggt gac att gcc tct tac ttt gtc   864
Lys Pro Ile Thr Tyr Glu Ser Glu Gly Asp Ile Ala Ser Tyr Phe Val
        275                 280                 285
 
acc aga tac ggc ttc aac ccc gac tgt aaa atc tac tcg ttc acc gga   912
Thr Arg Tyr Gly Phe Asn Pro Asp Cys Lys Ile Tyr Ser Phe Thr Gly
    290                 295                 300
 
gac aat ttg gcc acg att atc tcg ttg cct ttg gct cca aat gat gct   960
Asp Asn Leu Ala Thr Ile Ile Ser Leu Pro Leu Ala Pro Asn Asp Ala
305                 310                 315                 320
 
ttg atc tca ttg ggt act tct act aca gtt tta att atc acc aag aac   1008
Leu Ile Ser Leu Gly Thr Ser Thr Thr Val Leu Ile Ile Thr Lys Asn
                325                 330                 335
 
tac gct cct tct tct caa tac cat ttg ttt aaa cat cca acc atg cct   1056
Tyr Ala Pro Ser Ser Gln Tyr His Leu Phe Lys His Pro Thr Met Pro
            340                 345                 350
 
gac cac tac atg ggc atg atc tgc tac tgt aac ggt tcc ttg gcc aga   1104
Asp His Tyr Met Gly Met Ile Cys Tyr Cys Asn Gly Ser Leu Ala Arg
        355                 360                 365
 
gaa aag gtt aga gac gaa gtc aac gaa aag ttc aat gta gaa gac aag   1152
Glu Lys Val Arg Asp Glu Val Asn Glu Lys Phe Asn Val Glu Asp Lys
    370                 375                 380
 
aag tcg tgg gac aag ttc aat gaa atc ttg gac aaa tcc aca gac ttc   1200
Lys Ser Trp Asp Lys Phe Asn Glu Ile Leu Asp Lys Ser Thr Asp Phe
385                 390                 395                 400
 
aac aac aag ttg ggt att tac ttc cca ctt ggc gaa att gtc cct aat   1248
Asn Asn Lys Leu Gly Ile Tyr Phe Pro Leu Gly Glu Ile Val Pro Asn
                405                 410                 415
 
gcc gct gct cag atc aag aga tcg gtg ttg aac agc aag aac gaa att   1296
Ala Ala Ala Gln Ile Lys Arg Ser Val Leu Asn Ser Lys Asn Glu Ile
            420                 425                 430
 
gta gac gtt gag ttg ggc gac aag aac tgg caa cct gaa gat gat gtt   1344
Val Asp Val Glu Leu Gly Asp Lys Asn Trp Gln Pro Glu Asp Asp Val
        435                 440                 445
 
tct tca att gta gaa tca cag act ttg tct tgt aga ttg aga act ggt   1392
Ser Ser Ile Val Glu Ser Gln Thr Leu Ser Cys Arg Leu Arg Thr Gly
    450                 455                 460
 
cca atg ttg agc aag agt gga gat tct tct gct tcc agc tct gcc tca   1440
Pro Met Leu Ser Lys Ser Gly Asp Ser Ser Ala Ser Ser Ser Ala Ser
465                 470                 475                 480
 
cct caa cca gaa ggt gat ggt aca gat ttg cac aag gtc tac caa gac   1488
Pro Gln Pro Glu Gly Asp Gly Thr Asp Leu His Lys Val Tyr Gln Asp
                485                 490                 495
 
ttg gtt aaa aag ttt ggt gac ttg ttc act gat gga aag aag caa acc   1536
Leu Val Lys Lys Phe Gly Asp Leu Phe Thr Asp Gly Lys Lys Gln Thr
            500                 505                 510
 
ttt gag tct ttg acc gcc aga cct aac cgt tgt tac tac gtc ggt ggt   1584
Phe Glu Ser Leu Thr Ala Arg Pro Asn Arg Cys Tyr Tyr Val Gly Gly
        515                 520                 525
 
gct tcc aac aac ggc agc att atc aag atg ggt tcc atc ttg gct ccc   1632
Ala Ser Asn Asn Gly Ser Ile Ile Lys Met Gly Ser Ile Leu Ala Pro
    530                 535                 540
 
gtc aac gga aac tac aag gtt gac att cct aac gcc tgt gca ttg ggt   1680
Val Asn Gly Asn Tyr Lys Val Asp Ile Pro Asn Ala Cys Ala Leu Gly
545                 550                 555                 560
 
ggt gct tac aag gcc agt tgg agt tac gag tgt gaa gcc aag aag gaa   1728
Gly Ala Tyr Lys Ala Ser Trp Ser Tyr Glu Cys Glu Ala Lys Lys Glu
                565                 570                 575
 
tgg atc gga tac gat cag tat atc aac aga ttg ttt gaa gta agt gac   1776
Trp Ile Gly Tyr Asp Gln Tyr Ile Asn Arg Leu Phe Glu Val Ser Asp
            580                 585                 590
 
gag atg aat ctg ttc gaa gtc aag gat aaa tgg ctc gaa tat gcc aac   1824
Glu Met Asn Leu Phe Glu Val Lys Asp Lys Trp Leu Glu Tyr Ala Asn
        595                 600                 605
 
ggg gtt gga atg ttg gcc aag atg gaa agt gaa ttg aaa cac taa       1869
Gly Val Gly Met Leu Ala Lys Met Glu Ser Glu Leu Lys His  *
    610                 615                 620
 


<210> 74
<211> 622
<212> PRT
<213> P. stipitis

<400> 74
Met Thr Thr Thr Pro Phe Asp Ala Pro Asp Lys Leu Phe Leu Gly Phe
 1               5                  10                  15      
Asp Leu Ser Thr Gln Gln Leu Lys Ile Ile Val Thr Asp Glu Asn Leu
            20                  25                  30          
Ala Ala Leu Lys Thr Tyr Asn Val Glu Phe Asp Ser Ile Asn Ser Ser
        35                  40                  45              
Val Gln Lys Gly Val Ile Ala Ile Asn Asp Glu Ile Ser Lys Gly Ala
    50                  55                  60                  
Ile Ile Ser Pro Val Tyr Met Trp Leu Asp Ala Leu Asp His Val Phe
65                  70                  75                  80  
Glu Asp Met Lys Lys Asp Gly Phe Pro Phe Asn Lys Val Val Gly Ile
                85                  90                  95      
Ser Gly Ser Cys Gln Gln His Gly Ser Val Tyr Trp Ser Arg Thr Ala
            100                 105                 110         
Glu Lys Val Leu Ser Glu Leu Asp Ala Glu Ser Ser Leu Ser Ser Gln
        115                 120                 125             
Met Arg Ser Ala Phe Thr Phe Lys His Ala Pro Asn Trp Gln Asp His
    130                 135                 140                 
Ser Thr Gly Lys Glu Leu Glu Glu Phe Glu Arg Val Ile Gly Ala Asp
145                 150                 155                 160 
Ala Leu Ala Asp Ile Ser Gly Ser Arg Ala His Tyr Arg Phe Thr Gly
                165                 170                 175     
Leu Gln Ile Arg Lys Leu Ser Thr Arg Phe Lys Pro Glu Lys Tyr Asn
            180                 185                 190         
Arg Thr Ala Arg Ile Ser Leu Val Ser Ser Phe Val Ala Ser Val Leu
        195                 200                 205             
Leu Gly Arg Ile Thr Ser Ile Glu Glu Ala Asp Ala Cys Gly Met Asn
    210                 215                 220                 
Leu Tyr Asp Ile Glu Lys Arg Glu Phe Asn Glu Glu Leu Leu Ala Ile
225                 230                 235                 240 
Ala Ala Gly Val His Pro Glu Leu Asp Gly Val Glu Gln Asp Gly Glu
                245                 250                 255     
Ile Tyr Arg Ala Gly Ile Asn Glu Leu Lys Arg Lys Leu Gly Pro Val
            260                 265                 270         
Lys Pro Ile Thr Tyr Glu Ser Glu Gly Asp Ile Ala Ser Tyr Phe Val
        275                 280                 285             
Thr Arg Tyr Gly Phe Asn Pro Asp Cys Lys Ile Tyr Ser Phe Thr Gly
    290                 295                 300                 
Asp Asn Leu Ala Thr Ile Ile Ser Leu Pro Leu Ala Pro Asn Asp Ala
305                 310                 315                 320 
Leu Ile Ser Leu Gly Thr Ser Thr Thr Val Leu Ile Ile Thr Lys Asn
                325                 330                 335     
Tyr Ala Pro Ser Ser Gln Tyr His Leu Phe Lys His Pro Thr Met Pro
            340                 345                 350         
Asp His Tyr Met Gly Met Ile Cys Tyr Cys Asn Gly Ser Leu Ala Arg
        355                 360                 365             
Glu Lys Val Arg Asp Glu Val Asn Glu Lys Phe Asn Val Glu Asp Lys
    370                 375                 380                 
Lys Ser Trp Asp Lys Phe Asn Glu Ile Leu Asp Lys Ser Thr Asp Phe
385                 390                 395                 400 
Asn Asn Lys Leu Gly Ile Tyr Phe Pro Leu Gly Glu Ile Val Pro Asn
                405                 410                 415     
Ala Ala Ala Gln Ile Lys Arg Ser Val Leu Asn Ser Lys Asn Glu Ile
            420                 425                 430         
Val Asp Val Glu Leu Gly Asp Lys Asn Trp Gln Pro Glu Asp Asp Val
        435                 440                 445             
Ser Ser Ile Val Glu Ser Gln Thr Leu Ser Cys Arg Leu Arg Thr Gly
    450                 455                 460                 
Pro Met Leu Ser Lys Ser Gly Asp Ser Ser Ala Ser Ser Ser Ala Ser
465                 470                 475                 480 
Pro Gln Pro Glu Gly Asp Gly Thr Asp Leu His Lys Val Tyr Gln Asp
                485                 490                 495     
Leu Val Lys Lys Phe Gly Asp Leu Phe Thr Asp Gly Lys Lys Gln Thr
            500                 505                 510         
Phe Glu Ser Leu Thr Ala Arg Pro Asn Arg Cys Tyr Tyr Val Gly Gly
        515                 520                 525             
Ala Ser Asn Asn Gly Ser Ile Ile Lys Met Gly Ser Ile Leu Ala Pro
    530                 535                 540                 
Val Asn Gly Asn Tyr Lys Val Asp Ile Pro Asn Ala Cys Ala Leu Gly
545                 550                 555                 560 
Gly Ala Tyr Lys Ala Ser Trp Ser Tyr Glu Cys Glu Ala Lys Lys Glu
                565                 570                 575     
Trp Ile Gly Tyr Asp Gln Tyr Ile Asn Arg Leu Phe Glu Val Ser Asp
            580                 585                 590         
Glu Met Asn Leu Phe Glu Val Lys Asp Lys Trp Leu Glu Tyr Ala Asn
        595                 600                 605             
Gly Val Gly Met Leu Ala Lys Met Glu Ser Glu Leu Lys His
    610                 615                 620         


<210> 75
<211> 1866
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in S. cerevisiae

<220> 
<221> CDS            
<222> (1)...(1866)

<400> 75
atg act act act cca ttt gat gct cca gat aaa ttg ttt ttg ggt ttt   48
Met Thr Thr Thr Pro Phe Asp Ala Pro Asp Lys Leu Phe Leu Gly Phe
 1               5                   10                  15
 
gat ttg tca act caa caa tta aaa att att gtt act gat gaa aat tta   96
Asp Leu Ser Thr Gln Gln Leu Lys Ile Ile Val Thr Asp Glu Asn Leu
             20                  25                  30
 
gct gct tta aaa act tat aat gtt gaa ttt gat tct att aat tct tct   144
Ala Ala Leu Lys Thr Tyr Asn Val Glu Phe Asp Ser Ile Asn Ser Ser
         35                  40                  45
 
gtt caa aaa ggt gta att gct att aat gat gaa att tct aaa ggt gct   192
Val Gln Lys Gly Val Ile Ala Ile Asn Asp Glu Ile Ser Lys Gly Ala
     50                  55                  60
 
att att tca cca gtt tat atg tgg ttg gac gct tta gat cat gta ttt   240
Ile Ile Ser Pro Val Tyr Met Trp Leu Asp Ala Leu Asp His Val Phe
 65                  70                  75                  80
 
gaa gat atg aaa aag gac ggc ttt cca ttt aat aaa gta gtt gga att   288
Glu Asp Met Lys Lys Asp Gly Phe Pro Phe Asn Lys Val Val Gly Ile
                 85                  90                  95
 
tct ggt tct tgt caa caa cat ggt tct gtt tat tgg tct aga act gct   336
Ser Gly Ser Cys Gln Gln His Gly Ser Val Tyr Trp Ser Arg Thr Ala
            100                 105                 110
 
gaa aaa gta ttg tct gaa ttg gat gct gaa tct tct ttg tct tca caa   384
Glu Lys Val Leu Ser Glu Leu Asp Ala Glu Ser Ser Leu Ser Ser Gln
        115                 120                 125
 
atg aga tct gct ttt act ttt aaa cat gct cca aat tgg caa gat cat   432
Met Arg Ser Ala Phe Thr Phe Lys His Ala Pro Asn Trp Gln Asp His
    130                 135                 140
 
tca act ggt aaa gaa ttg gaa gaa ttt gaa aga gta att ggt gct gat   480
Ser Thr Gly Lys Glu Leu Glu Glu Phe Glu Arg Val Ile Gly Ala Asp
145                 150                 155                 160
 
gct ttg gct gat ata tct ggt tct agg gct cat tat aga ttt act ggt   528
Ala Leu Ala Asp Ile Ser Gly Ser Arg Ala His Tyr Arg Phe Thr Gly
                165                 170                 175
 
ttg caa att aga aaa ttg tca act aga ttt aaa cca gaa aaa tat aat   576
Leu Gln Ile Arg Lys Leu Ser Thr Arg Phe Lys Pro Glu Lys Tyr Asn
            180                 185                 190
 
aga aca gcg aga att tct ttg gtt tca tct ttt gta gct tct gtt ttg   624
Arg Thr Ala Arg Ile Ser Leu Val Ser Ser Phe Val Ala Ser Val Leu
        195                 200                 205
 
ttg ggt aga att aca tct att gaa gag gct gat gct tgt ggt atg aat   672
Leu Gly Arg Ile Thr Ser Ile Glu Glu Ala Asp Ala Cys Gly Met Asn
    210                 215                 220
 
ttg tat gac att gaa aaa cgt gaa ttt aat gaa gaa ttg ttg gct att   720
Leu Tyr Asp Ile Glu Lys Arg Glu Phe Asn Glu Glu Leu Leu Ala Ile
225                 230                 235                 240
 
gct gcg ggt gtt cat cca gaa tta gat ggt gtt gaa caa gat gga gaa   768
Ala Ala Gly Val His Pro Glu Leu Asp Gly Val Glu Gln Asp Gly Glu
                245                 250                 255
 
att tat aga gct gga att aat gaa tta aaa aga aaa ttg ggt cca gtt   816
Ile Tyr Arg Ala Gly Ile Asn Glu Leu Lys Arg Lys Leu Gly Pro Val
            260                 265                 270
 
aaa ccg ata act tat gaa tct gaa ggt gat ata gct tct tat ttt gta   864
Lys Pro Ile Thr Tyr Glu Ser Glu Gly Asp Ile Ala Ser Tyr Phe Val
        275                 280                 285
 
act aga tat ggt ttt aat cca gat tgt aaa att tat tct ttt act ggt   912
Thr Arg Tyr Gly Phe Asn Pro Asp Cys Lys Ile Tyr Ser Phe Thr Gly
    290                 295                 300
 
gat aat ttg gcc act att att tct ttg ccc tta gct cca aat gat gct   960
Asp Asn Leu Ala Thr Ile Ile Ser Leu Pro Leu Ala Pro Asn Asp Ala
305                 310                 315                 320
 
ttg att tct ttg ggt act tca act act gtt ttg att att act aaa aat   1008
Leu Ile Ser Leu Gly Thr Ser Thr Thr Val Leu Ile Ile Thr Lys Asn
                325                 330                 335
 
tat gct cca tct tca caa tat cat tta ttt aaa cat cca act atg cca   1056
Tyr Ala Pro Ser Ser Gln Tyr His Leu Phe Lys His Pro Thr Met Pro
            340                 345                 350
 
gat cat tat atg ggt atg att tgt tat tgt aat ggt tct ttg gct aga   1104
Asp His Tyr Met Gly Met Ile Cys Tyr Cys Asn Gly Ser Leu Ala Arg
        355                 360                 365
 
gaa aaa gta aga gat gaa gtt aat gaa aaa ttt aat gtt gaa gat aaa   1152
Glu Lys Val Arg Asp Glu Val Asn Glu Lys Phe Asn Val Glu Asp Lys
    370                 375                 380
 
aag tct tgg gat aaa ttt aat gaa att ttg gat aaa tca act gat ttt   1200
Lys Ser Trp Asp Lys Phe Asn Glu Ile Leu Asp Lys Ser Thr Asp Phe
385                 390                 395                 400
 
aat aat aag ttg gga att tat ttt cca ttg ggt gaa att gtt cca aat   1248
Asn Asn Lys Leu Gly Ile Tyr Phe Pro Leu Gly Glu Ile Val Pro Asn
                405                 410                 415
 
gct gct gca caa att aag aga tct gtt tta aat tct aaa aat gaa att   1296
Ala Ala Ala Gln Ile Lys Arg Ser Val Leu Asn Ser Lys Asn Glu Ile
            420                 425                 430
 
gtc gat gtt gaa ttg gga gat aaa aat tgg caa cca gag gat gat gta   1344
Val Asp Val Glu Leu Gly Asp Lys Asn Trp Gln Pro Glu Asp Asp Val
        435                 440                 445
 
tct tct att gtt gaa tca caa act cta tct tgt aga ttg aga act ggt   1392
Ser Ser Ile Val Glu Ser Gln Thr Leu Ser Cys Arg Leu Arg Thr Gly
    450                 455                 460
 
cca atg ttg tct aaa tct ggt gat tct tct gct tct tca tct gca tca   1440
Pro Met Leu Ser Lys Ser Gly Asp Ser Ser Ala Ser Ser Ser Ala Ser
465                 470                 475                 480
 
cca caa ccc gaa gga gac ggt act gat ttg cat aag gtt tat caa gat   1488
Pro Gln Pro Glu Gly Asp Gly Thr Asp Leu His Lys Val Tyr Gln Asp
                485                 490                 495
 
ttg gtt aaa aag ttc ggt gat ttg ttt act gat ggt aaa aag caa act   1536
Leu Val Lys Lys Phe Gly Asp Leu Phe Thr Asp Gly Lys Lys Gln Thr
            500                 505                 510
 
ttc gaa tct ttg act gct aga cca aat aga tgt tat tat gtt ggt ggt   1584
Phe Glu Ser Leu Thr Ala Arg Pro Asn Arg Cys Tyr Tyr Val Gly Gly
        515                 520                 525
 
gct tct aat aat ggt tct att att aaa atg ggt tct att ttg gct cca   1632
Ala Ser Asn Asn Gly Ser Ile Ile Lys Met Gly Ser Ile Leu Ala Pro
    530                 535                 540
 
gtt aat ggt aat tat aag gtt gat ata cca aat gct tgt gct ctc gga   1680
Val Asn Gly Asn Tyr Lys Val Asp Ile Pro Asn Ala Cys Ala Leu Gly
545                 550                 555                 560
 
ggt gct tat aaa gcc tct tgg tct tat gaa tgt gaa gct aaa aag gaa   1728
Gly Ala Tyr Lys Ala Ser Trp Ser Tyr Glu Cys Glu Ala Lys Lys Glu
                565                 570                 575
 
tgg ata ggt tat gat caa tac att aat aga ttg ttt gaa gtt tca gat   1776
Trp Ile Gly Tyr Asp Gln Tyr Ile Asn Arg Leu Phe Glu Val Ser Asp
            580                 585                 590
 
gaa atg aat ttg ttc gaa gtt aaa gat aaa tgg ttg gaa tat gct aat   1824
Glu Met Asn Leu Phe Glu Val Lys Asp Lys Trp Leu Glu Tyr Ala Asn
        595                 600                 605
 
ggt gtt ggt atg ttg gct aag atg gaa tca gaa tta aaa cat           1866
Gly Val Gly Met Leu Ala Lys Met Glu Ser Glu Leu Lys His
    610                 615                 620
 


<210> 76
<211> 622
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in S. cerevisiae

<400> 76
Met Thr Thr Thr Pro Phe Asp Ala Pro Asp Lys Leu Phe Leu Gly Phe
 1               5                  10                  15      
Asp Leu Ser Thr Gln Gln Leu Lys Ile Ile Val Thr Asp Glu Asn Leu
            20                  25                  30          
Ala Ala Leu Lys Thr Tyr Asn Val Glu Phe Asp Ser Ile Asn Ser Ser
        35                  40                  45              
Val Gln Lys Gly Val Ile Ala Ile Asn Asp Glu Ile Ser Lys Gly Ala
    50                  55                  60                  
Ile Ile Ser Pro Val Tyr Met Trp Leu Asp Ala Leu Asp His Val Phe
65                  70                  75                  80  
Glu Asp Met Lys Lys Asp Gly Phe Pro Phe Asn Lys Val Val Gly Ile
                85                  90                  95      
Ser Gly Ser Cys Gln Gln His Gly Ser Val Tyr Trp Ser Arg Thr Ala
            100                 105                 110         
Glu Lys Val Leu Ser Glu Leu Asp Ala Glu Ser Ser Leu Ser Ser Gln
        115                 120                 125             
Met Arg Ser Ala Phe Thr Phe Lys His Ala Pro Asn Trp Gln Asp His
    130                 135                 140                 
Ser Thr Gly Lys Glu Leu Glu Glu Phe Glu Arg Val Ile Gly Ala Asp
145                 150                 155                 160 
Ala Leu Ala Asp Ile Ser Gly Ser Arg Ala His Tyr Arg Phe Thr Gly
                165                 170                 175     
Leu Gln Ile Arg Lys Leu Ser Thr Arg Phe Lys Pro Glu Lys Tyr Asn
            180                 185                 190         
Arg Thr Ala Arg Ile Ser Leu Val Ser Ser Phe Val Ala Ser Val Leu
        195                 200                 205             
Leu Gly Arg Ile Thr Ser Ile Glu Glu Ala Asp Ala Cys Gly Met Asn
    210                 215                 220                 
Leu Tyr Asp Ile Glu Lys Arg Glu Phe Asn Glu Glu Leu Leu Ala Ile
225                 230                 235                 240 
Ala Ala Gly Val His Pro Glu Leu Asp Gly Val Glu Gln Asp Gly Glu
                245                 250                 255     
Ile Tyr Arg Ala Gly Ile Asn Glu Leu Lys Arg Lys Leu Gly Pro Val
            260                 265                 270         
Lys Pro Ile Thr Tyr Glu Ser Glu Gly Asp Ile Ala Ser Tyr Phe Val
        275                 280                 285             
Thr Arg Tyr Gly Phe Asn Pro Asp Cys Lys Ile Tyr Ser Phe Thr Gly
    290                 295                 300                 
Asp Asn Leu Ala Thr Ile Ile Ser Leu Pro Leu Ala Pro Asn Asp Ala
305                 310                 315                 320 
Leu Ile Ser Leu Gly Thr Ser Thr Thr Val Leu Ile Ile Thr Lys Asn
                325                 330                 335     
Tyr Ala Pro Ser Ser Gln Tyr His Leu Phe Lys His Pro Thr Met Pro
            340                 345                 350         
Asp His Tyr Met Gly Met Ile Cys Tyr Cys Asn Gly Ser Leu Ala Arg
        355                 360                 365             
Glu Lys Val Arg Asp Glu Val Asn Glu Lys Phe Asn Val Glu Asp Lys
    370                 375                 380                 
Lys Ser Trp Asp Lys Phe Asn Glu Ile Leu Asp Lys Ser Thr Asp Phe
385                 390                 395                 400 
Asn Asn Lys Leu Gly Ile Tyr Phe Pro Leu Gly Glu Ile Val Pro Asn
                405                 410                 415     
Ala Ala Ala Gln Ile Lys Arg Ser Val Leu Asn Ser Lys Asn Glu Ile
            420                 425                 430         
Val Asp Val Glu Leu Gly Asp Lys Asn Trp Gln Pro Glu Asp Asp Val
        435                 440                 445             
Ser Ser Ile Val Glu Ser Gln Thr Leu Ser Cys Arg Leu Arg Thr Gly
    450                 455                 460                 
Pro Met Leu Ser Lys Ser Gly Asp Ser Ser Ala Ser Ser Ser Ala Ser
465                 470                 475                 480 
Pro Gln Pro Glu Gly Asp Gly Thr Asp Leu His Lys Val Tyr Gln Asp
                485                 490                 495     
Leu Val Lys Lys Phe Gly Asp Leu Phe Thr Asp Gly Lys Lys Gln Thr
            500                 505                 510         
Phe Glu Ser Leu Thr Ala Arg Pro Asn Arg Cys Tyr Tyr Val Gly Gly
        515                 520                 525             
Ala Ser Asn Asn Gly Ser Ile Ile Lys Met Gly Ser Ile Leu Ala Pro
    530                 535                 540                 
Val Asn Gly Asn Tyr Lys Val Asp Ile Pro Asn Ala Cys Ala Leu Gly
545                 550                 555                 560 
Gly Ala Tyr Lys Ala Ser Trp Ser Tyr Glu Cys Glu Ala Lys Lys Glu
                565                 570                 575     
Trp Ile Gly Tyr Asp Gln Tyr Ile Asn Arg Leu Phe Glu Val Ser Asp
            580                 585                 590         
Glu Met Asn Leu Phe Glu Val Lys Asp Lys Trp Leu Glu Tyr Ala Asn
        595                 600                 605             
Gly Val Gly Met Leu Ala Lys Met Glu Ser Glu Leu Lys His
    610                 615                 620         


<210> 77
<211> 1888
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in S. cerevisiae

<220> 
<221> CDS            
<222> (12)...(1878)

<400> 77
tactcaagct t atg act act act cca ttt gat gct cca gat aaa ttg ttt  50
             Met Thr Thr Thr Pro Phe Asp Ala Pro Asp Lys Leu Phe
              1               5                   10
 
ttg ggt ttt gat ttg tca act caa caa tta aaa att att gtt act gat   98
Leu Gly Phe Asp Leu Ser Thr Gln Gln Leu Lys Ile Ile Val Thr Asp
     15                  20                  25
 
gaa aat tta gct gct tta aaa act tat aat gtt gaa ttt gat tct att   146
Glu Asn Leu Ala Ala Leu Lys Thr Tyr Asn Val Glu Phe Asp Ser Ile
 30                  35                  40                  45
 
aat tct tct gtt caa aaa ggt gta att gct att aat gat gaa att tct   194
Asn Ser Ser Val Gln Lys Gly Val Ile Ala Ile Asn Asp Glu Ile Ser
                 50                  55                  60
 
aaa ggt gct att att tca cca gtt tat atg tgg ttg gac gct tta gat   242
Lys Gly Ala Ile Ile Ser Pro Val Tyr Met Trp Leu Asp Ala Leu Asp
             65                  70                  75
 
cat gta ttt gaa gat atg aaa aag gac ggc ttt cca ttt aat aaa gta   290
His Val Phe Glu Asp Met Lys Lys Asp Gly Phe Pro Phe Asn Lys Val
         80                  85                  90
 
gtt gga att tct ggt tct tgt caa caa cat ggt tct gtt tat tgg tct   338
Val Gly Ile Ser Gly Ser Cys Gln Gln His Gly Ser Val Tyr Trp Ser
     95                 100                 105
 
aga act gct gaa aaa gta ttg tct gaa ttg gat gct gaa tct tct ttg   386
Arg Thr Ala Glu Lys Val Leu Ser Glu Leu Asp Ala Glu Ser Ser Leu
110                 115                 120                 125
 
tct tca caa atg aga tct gct ttt act ttt aaa cat gct cca aat tgg   434
Ser Ser Gln Met Arg Ser Ala Phe Thr Phe Lys His Ala Pro Asn Trp
                130                 135                 140
 
caa gat cat tca act ggt aaa gaa ttg gaa gaa ttt gaa aga gta att   482
Gln Asp His Ser Thr Gly Lys Glu Leu Glu Glu Phe Glu Arg Val Ile
            145                 150                 155
 
ggt gct gat gct ttg gct gat ata tct ggt tct agg gct cat tat aga   530
Gly Ala Asp Ala Leu Ala Asp Ile Ser Gly Ser Arg Ala His Tyr Arg
        160                 165                 170
 
ttt act ggt ttg caa att aga aaa ttg tca act aga ttt aaa cca gaa   578
Phe Thr Gly Leu Gln Ile Arg Lys Leu Ser Thr Arg Phe Lys Pro Glu
    175                 180                 185
 
aaa tat aat aga aca gcg aga att tct ttg gtt tca tct ttt gta gct   626
Lys Tyr Asn Arg Thr Ala Arg Ile Ser Leu Val Ser Ser Phe Val Ala
190                 195                 200                 205
 
tct gtt ttg ttg ggt aga att aca tct att gaa gag gct gat gct tgt   674
Ser Val Leu Leu Gly Arg Ile Thr Ser Ile Glu Glu Ala Asp Ala Cys
                210                 215                 220
 
ggt atg aat ttg tat gac att gaa aaa cgt gaa ttt aat gaa gaa ttg   722
Gly Met Asn Leu Tyr Asp Ile Glu Lys Arg Glu Phe Asn Glu Glu Leu
            225                 230                 235
 
ttg gct att gct gcg ggt gtt cat cca gaa tta gat ggt gtt gaa caa   770
Leu Ala Ile Ala Ala Gly Val His Pro Glu Leu Asp Gly Val Glu Gln
        240                 245                 250
 
gat gga gaa att tat aga gct gga att aat gaa tta aaa aga aaa ttg   818
Asp Gly Glu Ile Tyr Arg Ala Gly Ile Asn Glu Leu Lys Arg Lys Leu
    255                 260                 265
 
ggt cca gtt aaa ccg ata act tat gaa tct gaa ggt gat ata gct tct   866
Gly Pro Val Lys Pro Ile Thr Tyr Glu Ser Glu Gly Asp Ile Ala Ser
270                 275                 280                 285
 
tat ttt gta act aga tat ggt ttt aat cca gat tgt aaa att tat tct   914
Tyr Phe Val Thr Arg Tyr Gly Phe Asn Pro Asp Cys Lys Ile Tyr Ser
                290                 295                 300
 
ttt act ggt gat aat ttg gcc act att att tct ttg ccc tta gct cca   962
Phe Thr Gly Asp Asn Leu Ala Thr Ile Ile Ser Leu Pro Leu Ala Pro
            305                 310                 315
 
aat gat gct ttg att tct ttg ggt act tca act act gtt ttg att att   1010
Asn Asp Ala Leu Ile Ser Leu Gly Thr Ser Thr Thr Val Leu Ile Ile
        320                 325                 330
 
act aaa aat tat gct cca tct tca caa tat cat tta ttt aaa cat cca   1058
Thr Lys Asn Tyr Ala Pro Ser Ser Gln Tyr His Leu Phe Lys His Pro
    335                 340                 345
 
act atg cca gat cat tat atg ggt atg att tgt tat tgt aat ggt tct   1106
Thr Met Pro Asp His Tyr Met Gly Met Ile Cys Tyr Cys Asn Gly Ser
350                 355                 360                 365
 
ttg gct aga gaa aaa gta aga gat gaa gtt aat gaa aaa ttt aat gtt   1154
Leu Ala Arg Glu Lys Val Arg Asp Glu Val Asn Glu Lys Phe Asn Val
                370                 375                 380
 
gaa gat aaa aag tct tgg gat aaa ttt aat gaa att ttg gat aaa tca   1202
Glu Asp Lys Lys Ser Trp Asp Lys Phe Asn Glu Ile Leu Asp Lys Ser
            385                 390                 395
 
act gat ttt aat aat aag ttg gga att tat ttt cca ttg ggt gaa att   1250
Thr Asp Phe Asn Asn Lys Leu Gly Ile Tyr Phe Pro Leu Gly Glu Ile
        400                 405                 410
 
gtt cca aat gct gct gca caa att aag aga tct gtt tta aat tct aaa   1298
Val Pro Asn Ala Ala Ala Gln Ile Lys Arg Ser Val Leu Asn Ser Lys
    415                 420                 425
 
aat gaa att gtc gat gtt gaa ttg gga gat aaa aat tgg caa cca gag   1346
Asn Glu Ile Val Asp Val Glu Leu Gly Asp Lys Asn Trp Gln Pro Glu
430                 435                 440                 445
 
gat gat gta tct tct att gtt gaa tca caa act cta tct tgt aga ttg   1394
Asp Asp Val Ser Ser Ile Val Glu Ser Gln Thr Leu Ser Cys Arg Leu
                450                 455                 460
 
aga act ggt cca atg ttg tct aaa tct ggt gat tct tct gct tct tca   1442
Arg Thr Gly Pro Met Leu Ser Lys Ser Gly Asp Ser Ser Ala Ser Ser
            465                 470                 475
 
tct gca tca cca caa ccc gaa gga gac ggt act gat ttg cat aag gtt   1490
Ser Ala Ser Pro Gln Pro Glu Gly Asp Gly Thr Asp Leu His Lys Val
        480                 485                 490
 
tat caa gat ttg gtt aaa aag ttc ggt gat ttg ttt act gat ggt aaa   1538
Tyr Gln Asp Leu Val Lys Lys Phe Gly Asp Leu Phe Thr Asp Gly Lys
    495                 500                 505
 
aag caa act ttc gaa tct ttg act gct aga cca aat aga tgt tat tat   1586
Lys Gln Thr Phe Glu Ser Leu Thr Ala Arg Pro Asn Arg Cys Tyr Tyr
510                 515                 520                 525
 
gtt ggt ggt gct tct aat aat ggt tct att att aaa atg ggt tct att   1634
Val Gly Gly Ala Ser Asn Asn Gly Ser Ile Ile Lys Met Gly Ser Ile
                530                 535                 540
 
ttg gct cca gtt aat ggt aat tat aag gtt gat ata cca aat gct tgt   1682
Leu Ala Pro Val Asn Gly Asn Tyr Lys Val Asp Ile Pro Asn Ala Cys
            545                 550                 555
 
gct ctc gga ggt gct tat aaa gcc tct tgg tct tat gaa tgt gaa gct   1730
Ala Leu Gly Gly Ala Tyr Lys Ala Ser Trp Ser Tyr Glu Cys Glu Ala
        560                 565                 570
 
aaa aag gaa tgg ata ggt tat gat caa tac att aat aga ttg ttt gaa   1778
Lys Lys Glu Trp Ile Gly Tyr Asp Gln Tyr Ile Asn Arg Leu Phe Glu
    575                 580                 585
 
gtt tca gat gaa atg aat ttg ttc gaa gtt aaa gat aaa tgg ttg gaa   1826
Val Ser Asp Glu Met Asn Leu Phe Glu Val Lys Asp Lys Trp Leu Glu
590                 595                 600                 605
 
tat gct aat ggt gtt ggt atg ttg gct aag atg gaa tca gaa tta aaa   1874
Tyr Ala Asn Gly Val Gly Met Leu Ala Lys Met Glu Ser Glu Leu Lys
                610                 615                 620
 
cat g aattccgatg                                                  1888
His

 

<210> 78
<211> 622
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in S. cerevisiae

<400> 78
Met Thr Thr Thr Pro Phe Asp Ala Pro Asp Lys Leu Phe Leu Gly Phe
 1               5                  10                  15      
Asp Leu Ser Thr Gln Gln Leu Lys Ile Ile Val Thr Asp Glu Asn Leu
            20                  25                  30          
Ala Ala Leu Lys Thr Tyr Asn Val Glu Phe Asp Ser Ile Asn Ser Ser
        35                  40                  45              
Val Gln Lys Gly Val Ile Ala Ile Asn Asp Glu Ile Ser Lys Gly Ala
    50                  55                  60                  
Ile Ile Ser Pro Val Tyr Met Trp Leu Asp Ala Leu Asp His Val Phe
65                  70                  75                  80  
Glu Asp Met Lys Lys Asp Gly Phe Pro Phe Asn Lys Val Val Gly Ile
                85                  90                  95      
Ser Gly Ser Cys Gln Gln His Gly Ser Val Tyr Trp Ser Arg Thr Ala
            100                 105                 110         
Glu Lys Val Leu Ser Glu Leu Asp Ala Glu Ser Ser Leu Ser Ser Gln
        115                 120                 125             
Met Arg Ser Ala Phe Thr Phe Lys His Ala Pro Asn Trp Gln Asp His
    130                 135                 140                 
Ser Thr Gly Lys Glu Leu Glu Glu Phe Glu Arg Val Ile Gly Ala Asp
145                 150                 155                 160 
Ala Leu Ala Asp Ile Ser Gly Ser Arg Ala His Tyr Arg Phe Thr Gly
                165                 170                 175     
Leu Gln Ile Arg Lys Leu Ser Thr Arg Phe Lys Pro Glu Lys Tyr Asn
            180                 185                 190         
Arg Thr Ala Arg Ile Ser Leu Val Ser Ser Phe Val Ala Ser Val Leu
        195                 200                 205             
Leu Gly Arg Ile Thr Ser Ile Glu Glu Ala Asp Ala Cys Gly Met Asn
    210                 215                 220                 
Leu Tyr Asp Ile Glu Lys Arg Glu Phe Asn Glu Glu Leu Leu Ala Ile
225                 230                 235                 240 
Ala Ala Gly Val His Pro Glu Leu Asp Gly Val Glu Gln Asp Gly Glu
                245                 250                 255     
Ile Tyr Arg Ala Gly Ile Asn Glu Leu Lys Arg Lys Leu Gly Pro Val
            260                 265                 270         
Lys Pro Ile Thr Tyr Glu Ser Glu Gly Asp Ile Ala Ser Tyr Phe Val
        275                 280                 285             
Thr Arg Tyr Gly Phe Asn Pro Asp Cys Lys Ile Tyr Ser Phe Thr Gly
    290                 295                 300                 
Asp Asn Leu Ala Thr Ile Ile Ser Leu Pro Leu Ala Pro Asn Asp Ala
305                 310                 315                 320 
Leu Ile Ser Leu Gly Thr Ser Thr Thr Val Leu Ile Ile Thr Lys Asn
                325                 330                 335     
Tyr Ala Pro Ser Ser Gln Tyr His Leu Phe Lys His Pro Thr Met Pro
            340                 345                 350         
Asp His Tyr Met Gly Met Ile Cys Tyr Cys Asn Gly Ser Leu Ala Arg
        355                 360                 365             
Glu Lys Val Arg Asp Glu Val Asn Glu Lys Phe Asn Val Glu Asp Lys
    370                 375                 380                 
Lys Ser Trp Asp Lys Phe Asn Glu Ile Leu Asp Lys Ser Thr Asp Phe
385                 390                 395                 400 
Asn Asn Lys Leu Gly Ile Tyr Phe Pro Leu Gly Glu Ile Val Pro Asn
                405                 410                 415     
Ala Ala Ala Gln Ile Lys Arg Ser Val Leu Asn Ser Lys Asn Glu Ile
            420                 425                 430         
Val Asp Val Glu Leu Gly Asp Lys Asn Trp Gln Pro Glu Asp Asp Val
        435                 440                 445             
Ser Ser Ile Val Glu Ser Gln Thr Leu Ser Cys Arg Leu Arg Thr Gly
    450                 455                 460                 
Pro Met Leu Ser Lys Ser Gly Asp Ser Ser Ala Ser Ser Ser Ala Ser
465                 470                 475                 480 
Pro Gln Pro Glu Gly Asp Gly Thr Asp Leu His Lys Val Tyr Gln Asp
                485                 490                 495     
Leu Val Lys Lys Phe Gly Asp Leu Phe Thr Asp Gly Lys Lys Gln Thr
            500                 505                 510         
Phe Glu Ser Leu Thr Ala Arg Pro Asn Arg Cys Tyr Tyr Val Gly Gly
        515                 520                 525             
Ala Ser Asn Asn Gly Ser Ile Ile Lys Met Gly Ser Ile Leu Ala Pro
    530                 535                 540                 
Val Asn Gly Asn Tyr Lys Val Asp Ile Pro Asn Ala Cys Ala Leu Gly
545                 550                 555                 560 
Gly Ala Tyr Lys Ala Ser Trp Ser Tyr Glu Cys Glu Ala Lys Lys Glu
                565                 570                 575     
Trp Ile Gly Tyr Asp Gln Tyr Ile Asn Arg Leu Phe Glu Val Ser Asp
            580                 585                 590         
Glu Met Asn Leu Phe Glu Val Lys Asp Lys Trp Leu Glu Tyr Ala Asn
        595                 600                 605             
Gly Val Gly Met Leu Ala Lys Met Glu Ser Glu Leu Lys His
    610                 615                 620         


<210> 79
<211> 1894
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in S. cerevisiae

<220> 
<221> CDS            
<222> (15)...(1880)

<400> 79
gaatactcca tatg atg act act act cca ttt gat gct cca gat aaa ttg   50
                Met Thr Thr Thr Pro Phe Asp Ala Pro Asp Lys Leu
                 1               5                   10
 
ttt ttg ggt ttt gat ttg tca act caa caa tta aaa att att gtt act   98
Phe Leu Gly Phe Asp Leu Ser Thr Gln Gln Leu Lys Ile Ile Val Thr
         15                  20                  25
 
gat gaa aat tta gct gct tta aaa act tat aat gtt gaa ttt gat tct   146
Asp Glu Asn Leu Ala Ala Leu Lys Thr Tyr Asn Val Glu Phe Asp Ser
     30                  35                  40
 
att aat tct tct gtt caa aaa ggt gta att gct att aat gat gaa att   194
Ile Asn Ser Ser Val Gln Lys Gly Val Ile Ala Ile Asn Asp Glu Ile
 45                  50                  55                  60
 
tct aaa ggt gct att att tca cca gtt tat atg tgg ttg gac gct tta   242
Ser Lys Gly Ala Ile Ile Ser Pro Val Tyr Met Trp Leu Asp Ala Leu
                 65                  70                  75
 
gat cat gta ttt gaa gat atg aaa aag gac ggc ttt cca ttt aat aaa   290
Asp His Val Phe Glu Asp Met Lys Lys Asp Gly Phe Pro Phe Asn Lys
             80                  85                  90
 
gta gtt gga att tct ggt tct tgt caa caa cat ggt tct gtt tat tgg   338
Val Val Gly Ile Ser Gly Ser Cys Gln Gln His Gly Ser Val Tyr Trp
         95                 100                 105
 
tct aga act gct gaa aaa gta ttg tct gaa ttg gat gct gaa tct tct   386
Ser Arg Thr Ala Glu Lys Val Leu Ser Glu Leu Asp Ala Glu Ser Ser
    110                 115                 120
 
ttg tct tca caa atg aga tct gct ttt act ttt aaa cat gct cca aat   434
Leu Ser Ser Gln Met Arg Ser Ala Phe Thr Phe Lys His Ala Pro Asn
125                 130                 135                 140
 
tgg caa gat cat tca act ggt aaa gaa ttg gaa gaa ttt gaa aga gta   482
Trp Gln Asp His Ser Thr Gly Lys Glu Leu Glu Glu Phe Glu Arg Val
                145                 150                 155
 
att ggt gct gat gct ttg gct gat ata tct ggt tct agg gct cat tat   530
Ile Gly Ala Asp Ala Leu Ala Asp Ile Ser Gly Ser Arg Ala His Tyr
            160                 165                 170
 
aga ttt act ggt ttg caa att aga aaa ttg tca act aga ttt aaa cca   578
Arg Phe Thr Gly Leu Gln Ile Arg Lys Leu Ser Thr Arg Phe Lys Pro
        175                 180                 185
 
gaa aaa tat aat aga aca gcg aga att tct ttg gtt tca tct ttt gta   626
Glu Lys Tyr Asn Arg Thr Ala Arg Ile Ser Leu Val Ser Ser Phe Val
    190                 195                 200
 
gct tct gtt ttg ttg ggt aga att aca tct att gaa gag gct gat gct   674
Ala Ser Val Leu Leu Gly Arg Ile Thr Ser Ile Glu Glu Ala Asp Ala
205                 210                 215                 220
 
tgt ggt atg aat ttg tat gac att gaa aaa cgt gaa ttt aat gaa gaa   722
Cys Gly Met Asn Leu Tyr Asp Ile Glu Lys Arg Glu Phe Asn Glu Glu
                225                 230                 235
 
ttg ttg gct att gct gcg ggt gtt cat cca gaa tta gat ggt gtt gaa   770
Leu Leu Ala Ile Ala Ala Gly Val His Pro Glu Leu Asp Gly Val Glu
            240                 245                 250
 
caa gat gga gaa att tat aga gct gga att aat gaa tta aaa aga aaa   818
Gln Asp Gly Glu Ile Tyr Arg Ala Gly Ile Asn Glu Leu Lys Arg Lys
        255                 260                 265
 
ttg ggt cca gtt aaa ccg ata act tat gaa tct gaa ggt gat ata gct   866
Leu Gly Pro Val Lys Pro Ile Thr Tyr Glu Ser Glu Gly Asp Ile Ala
    270                 275                 280
 
tct tat ttt gta act aga tat ggt ttt aat cca gat tgt aaa att tat   914
Ser Tyr Phe Val Thr Arg Tyr Gly Phe Asn Pro Asp Cys Lys Ile Tyr
285                 290                 295                 300
 
tct ttt act ggt gat aat ttg gcc act att att tct ttg ccc tta gct   962
Ser Phe Thr Gly Asp Asn Leu Ala Thr Ile Ile Ser Leu Pro Leu Ala
                305                 310                 315
 
cca aat gat gct ttg att tct ttg ggt act tca act act gtt ttg att   1010
Pro Asn Asp Ala Leu Ile Ser Leu Gly Thr Ser Thr Thr Val Leu Ile
            320                 325                 330
 
att act aaa aat tat gct cca tct tca caa tat cat tta ttt aaa cat   1058
Ile Thr Lys Asn Tyr Ala Pro Ser Ser Gln Tyr His Leu Phe Lys His
        335                 340                 345
 
cca act atg cca gat cat tat atg ggt atg att tgt tat tgt aat ggt   1106
Pro Thr Met Pro Asp His Tyr Met Gly Met Ile Cys Tyr Cys Asn Gly
    350                 355                 360
 
tct ttg gct aga gaa aaa gta aga gat gaa gtt aat gaa aaa ttt aat   1154
Ser Leu Ala Arg Glu Lys Val Arg Asp Glu Val Asn Glu Lys Phe Asn
365                 370                 375                 380
 
gtt gaa gat aaa aag tct tgg gat aaa ttt aat gaa att ttg gat aaa   1202
Val Glu Asp Lys Lys Ser Trp Asp Lys Phe Asn Glu Ile Leu Asp Lys
                385                 390                 395
 
tca act gat ttt aat aat aag ttg gga att tat ttt cca ttg ggt gaa   1250
Ser Thr Asp Phe Asn Asn Lys Leu Gly Ile Tyr Phe Pro Leu Gly Glu
            400                 405                 410
 
att gtt cca aat gct gct gca caa att aag aga tct gtt tta aat tct   1298
Ile Val Pro Asn Ala Ala Ala Gln Ile Lys Arg Ser Val Leu Asn Ser
        415                 420                 425
 
aaa aat gaa att gtc gat gtt gaa ttg gga gat aaa aat tgg caa cca   1346
Lys Asn Glu Ile Val Asp Val Glu Leu Gly Asp Lys Asn Trp Gln Pro
    430                 435                 440
 
gag gat gat gta tct tct att gtt gaa tca caa act cta tct tgt aga   1394
Glu Asp Asp Val Ser Ser Ile Val Glu Ser Gln Thr Leu Ser Cys Arg
445                 450                 455                 460
 
ttg aga act ggt cca atg ttg tct aaa tct ggt gat tct tct gct tct   1442
Leu Arg Thr Gly Pro Met Leu Ser Lys Ser Gly Asp Ser Ser Ala Ser
                465                 470                 475
 
tca tct gca tca cca caa ccc gaa gga gac ggt act gat ttg cat aag   1490
Ser Ser Ala Ser Pro Gln Pro Glu Gly Asp Gly Thr Asp Leu His Lys
            480                 485                 490
 
gtt tat caa gat ttg gtt aaa aag ttc ggt gat ttg ttt act gat ggt   1538
Val Tyr Gln Asp Leu Val Lys Lys Phe Gly Asp Leu Phe Thr Asp Gly
        495                 500                 505
 
aaa aag caa act ttc gaa tct ttg act gct aga cca aat aga tgt tat   1586
Lys Lys Gln Thr Phe Glu Ser Leu Thr Ala Arg Pro Asn Arg Cys Tyr
    510                 515                 520
 
tat gtt ggt ggt gct tct aat aat ggt tct att att aaa atg ggt tct   1634
Tyr Val Gly Gly Ala Ser Asn Asn Gly Ser Ile Ile Lys Met Gly Ser
525                 530                 535                 540
 
att ttg gct cca gtt aat ggt aat tat aag gtt gat ata cca aat gct   1682
Ile Leu Ala Pro Val Asn Gly Asn Tyr Lys Val Asp Ile Pro Asn Ala
                545                 550                 555
 
tgt gct ctc gga ggt gct tat aaa gcc tct tgg tct tat gaa tgt gaa   1730
Cys Ala Leu Gly Gly Ala Tyr Lys Ala Ser Trp Ser Tyr Glu Cys Glu
            560                 565                 570
 
gct aaa aag gaa tgg ata ggt tat gat caa tac att aat aga ttg ttt   1778
Ala Lys Lys Glu Trp Ile Gly Tyr Asp Gln Tyr Ile Asn Arg Leu Phe
        575                 580                 585
 
gaa gtt tca gat gaa atg aat ttg ttc gaa gtt aaa gat aaa tgg ttg   1826
Glu Val Ser Asp Glu Met Asn Leu Phe Glu Val Lys Asp Lys Trp Leu
    590                 595                 600
 
gaa tat gct aat ggt gtt ggt atg ttg gct aag atg gaa tca gaa tta   1874
Glu Tyr Ala Asn Gly Val Gly Met Leu Ala Lys Met Glu Ser Glu Leu
605                 610                 615                 620
 
aaa cat actagtcgat gcct                                           1894
Lys His

 

<210> 80
<211> 622
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in S. cerevisiae

<400> 80
Met Thr Thr Thr Pro Phe Asp Ala Pro Asp Lys Leu Phe Leu Gly Phe
 1               5                  10                  15      
Asp Leu Ser Thr Gln Gln Leu Lys Ile Ile Val Thr Asp Glu Asn Leu
            20                  25                  30          
Ala Ala Leu Lys Thr Tyr Asn Val Glu Phe Asp Ser Ile Asn Ser Ser
        35                  40                  45              
Val Gln Lys Gly Val Ile Ala Ile Asn Asp Glu Ile Ser Lys Gly Ala
    50                  55                  60                  
Ile Ile Ser Pro Val Tyr Met Trp Leu Asp Ala Leu Asp His Val Phe
65                  70                  75                  80  
Glu Asp Met Lys Lys Asp Gly Phe Pro Phe Asn Lys Val Val Gly Ile
                85                  90                  95      
Ser Gly Ser Cys Gln Gln His Gly Ser Val Tyr Trp Ser Arg Thr Ala
            100                 105                 110         
Glu Lys Val Leu Ser Glu Leu Asp Ala Glu Ser Ser Leu Ser Ser Gln
        115                 120                 125             
Met Arg Ser Ala Phe Thr Phe Lys His Ala Pro Asn Trp Gln Asp His
    130                 135                 140                 
Ser Thr Gly Lys Glu Leu Glu Glu Phe Glu Arg Val Ile Gly Ala Asp
145                 150                 155                 160 
Ala Leu Ala Asp Ile Ser Gly Ser Arg Ala His Tyr Arg Phe Thr Gly
                165                 170                 175     
Leu Gln Ile Arg Lys Leu Ser Thr Arg Phe Lys Pro Glu Lys Tyr Asn
            180                 185                 190         
Arg Thr Ala Arg Ile Ser Leu Val Ser Ser Phe Val Ala Ser Val Leu
        195                 200                 205             
Leu Gly Arg Ile Thr Ser Ile Glu Glu Ala Asp Ala Cys Gly Met Asn
    210                 215                 220                 
Leu Tyr Asp Ile Glu Lys Arg Glu Phe Asn Glu Glu Leu Leu Ala Ile
225                 230                 235                 240 
Ala Ala Gly Val His Pro Glu Leu Asp Gly Val Glu Gln Asp Gly Glu
                245                 250                 255     
Ile Tyr Arg Ala Gly Ile Asn Glu Leu Lys Arg Lys Leu Gly Pro Val
            260                 265                 270         
Lys Pro Ile Thr Tyr Glu Ser Glu Gly Asp Ile Ala Ser Tyr Phe Val
        275                 280                 285             
Thr Arg Tyr Gly Phe Asn Pro Asp Cys Lys Ile Tyr Ser Phe Thr Gly
    290                 295                 300                 
Asp Asn Leu Ala Thr Ile Ile Ser Leu Pro Leu Ala Pro Asn Asp Ala
305                 310                 315                 320 
Leu Ile Ser Leu Gly Thr Ser Thr Thr Val Leu Ile Ile Thr Lys Asn
                325                 330                 335     
Tyr Ala Pro Ser Ser Gln Tyr His Leu Phe Lys His Pro Thr Met Pro
            340                 345                 350         
Asp His Tyr Met Gly Met Ile Cys Tyr Cys Asn Gly Ser Leu Ala Arg
        355                 360                 365             
Glu Lys Val Arg Asp Glu Val Asn Glu Lys Phe Asn Val Glu Asp Lys
    370                 375                 380                 
Lys Ser Trp Asp Lys Phe Asn Glu Ile Leu Asp Lys Ser Thr Asp Phe
385                 390                 395                 400 
Asn Asn Lys Leu Gly Ile Tyr Phe Pro Leu Gly Glu Ile Val Pro Asn
                405                 410                 415     
Ala Ala Ala Gln Ile Lys Arg Ser Val Leu Asn Ser Lys Asn Glu Ile
            420                 425                 430         
Val Asp Val Glu Leu Gly Asp Lys Asn Trp Gln Pro Glu Asp Asp Val
        435                 440                 445             
Ser Ser Ile Val Glu Ser Gln Thr Leu Ser Cys Arg Leu Arg Thr Gly
    450                 455                 460                 
Pro Met Leu Ser Lys Ser Gly Asp Ser Ser Ala Ser Ser Ser Ala Ser
465                 470                 475                 480 
Pro Gln Pro Glu Gly Asp Gly Thr Asp Leu His Lys Val Tyr Gln Asp
                485                 490                 495     
Leu Val Lys Lys Phe Gly Asp Leu Phe Thr Asp Gly Lys Lys Gln Thr
            500                 505                 510         
Phe Glu Ser Leu Thr Ala Arg Pro Asn Arg Cys Tyr Tyr Val Gly Gly
        515                 520                 525             
Ala Ser Asn Asn Gly Ser Ile Ile Lys Met Gly Ser Ile Leu Ala Pro
    530                 535                 540                 
Val Asn Gly Asn Tyr Lys Val Asp Ile Pro Asn Ala Cys Ala Leu Gly
545                 550                 555                 560 
Gly Ala Tyr Lys Ala Ser Trp Ser Tyr Glu Cys Glu Ala Lys Lys Glu
                565                 570                 575     
Trp Ile Gly Tyr Asp Gln Tyr Ile Asn Arg Leu Phe Glu Val Ser Asp
            580                 585                 590         
Glu Met Asn Leu Phe Glu Val Lys Asp Lys Trp Leu Glu Tyr Ala Asn
        595                 600                 605             
Gly Val Gly Met Leu Ala Lys Met Glu Ser Glu Leu Lys His
    610                 615                 620         


<210> 81
<211> 1866
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in E. coli

<220> 
<221> CDS            
<222> (1)...(1866)

<400> 81
atg act act act cca ttt gat gct cca gat aaa ttg ttt ttg ggt ttt   48
Met Thr Thr Thr Pro Phe Asp Ala Pro Asp Lys Leu Phe Leu Gly Phe
 1               5                   10                  15
 
gat ttg tca act caa caa tta aaa att att gtt act gat gaa aat tta   96
Asp Leu Ser Thr Gln Gln Leu Lys Ile Ile Val Thr Asp Glu Asn Leu
             20                  25                  30
 
gct gct tta aaa act tat aat gtt gaa ttt gat tct att aat tct tct   144
Ala Ala Leu Lys Thr Tyr Asn Val Glu Phe Asp Ser Ile Asn Ser Ser
         35                  40                  45
 
gtt caa aaa ggt gta att gct att aat gat gaa att tct aaa ggt gct   192
Val Gln Lys Gly Val Ile Ala Ile Asn Asp Glu Ile Ser Lys Gly Ala
     50                  55                  60
 
att att tca cca gtt tat atg tgg ttg gac gct tta gat cat gta ttt   240
Ile Ile Ser Pro Val Tyr Met Trp Leu Asp Ala Leu Asp His Val Phe
 65                  70                  75                  80
 
gaa gat atg aaa aag gac ggc ttt cca ttt aat aaa gta gtt gga att   288
Glu Asp Met Lys Lys Asp Gly Phe Pro Phe Asn Lys Val Val Gly Ile
                 85                  90                  95
 
tct ggt tct tgt caa caa cat ggt tct gtt tat tgg tct aga act gct   336
Ser Gly Ser Cys Gln Gln His Gly Ser Val Tyr Trp Ser Arg Thr Ala
            100                 105                 110
 
gaa aaa gta ttg tct gaa ttg gat gct gaa tct tct ttg tct tca caa   384
Glu Lys Val Leu Ser Glu Leu Asp Ala Glu Ser Ser Leu Ser Ser Gln
        115                 120                 125
 
atg aga tct gct ttt act ttt aaa cat gct cca aat tgg caa gat cat   432
Met Arg Ser Ala Phe Thr Phe Lys His Ala Pro Asn Trp Gln Asp His
    130                 135                 140
 
tca act ggt aaa gaa ttg gaa gaa ttt gaa aga gta att ggt gct gat   480
Ser Thr Gly Lys Glu Leu Glu Glu Phe Glu Arg Val Ile Gly Ala Asp
145                 150                 155                 160
 
gct ttg gct gat ata tct ggt tct agg gct cat tat aga ttt act ggt   528
Ala Leu Ala Asp Ile Ser Gly Ser Arg Ala His Tyr Arg Phe Thr Gly
                165                 170                 175
 
ttg caa att aga aaa ttg tca act aga ttt aaa cca gaa aaa tat aat   576
Leu Gln Ile Arg Lys Leu Ser Thr Arg Phe Lys Pro Glu Lys Tyr Asn
            180                 185                 190
 
aga aca gcg aga att tct ttg gtt tca tct ttt gta gct tct gtt ttg   624
Arg Thr Ala Arg Ile Ser Leu Val Ser Ser Phe Val Ala Ser Val Leu
        195                 200                 205
 
ttg ggt aga att aca tct att gaa gag gct gat gct tgt ggt atg aat   672
Leu Gly Arg Ile Thr Ser Ile Glu Glu Ala Asp Ala Cys Gly Met Asn
    210                 215                 220
 
ttg tat gac att gaa aaa cgt gaa ttt aat gaa gaa ttg ttg gct att   720
Leu Tyr Asp Ile Glu Lys Arg Glu Phe Asn Glu Glu Leu Leu Ala Ile
225                 230                 235                 240
 
gct gcg ggt gtt cat cca gaa tta gat ggt gtt gaa caa gat gga gaa   768
Ala Ala Gly Val His Pro Glu Leu Asp Gly Val Glu Gln Asp Gly Glu
                245                 250                 255
 
att tat aga gct gga att aat gaa tta aaa aga aaa ttg ggt cca gtt   816
Ile Tyr Arg Ala Gly Ile Asn Glu Leu Lys Arg Lys Leu Gly Pro Val
            260                 265                 270
 
aaa ccg ata act tat gaa tct gaa ggt gat ata gct tct tat ttt gta   864
Lys Pro Ile Thr Tyr Glu Ser Glu Gly Asp Ile Ala Ser Tyr Phe Val
        275                 280                 285
 
act aga tat ggt ttt aat cca gat tgt aaa att tat tct ttt act ggt   912
Thr Arg Tyr Gly Phe Asn Pro Asp Cys Lys Ile Tyr Ser Phe Thr Gly
    290                 295                 300
 
gat aat ttg gcc act att att tct ttg ccc tta gct cca aat gat gct   960
Asp Asn Leu Ala Thr Ile Ile Ser Leu Pro Leu Ala Pro Asn Asp Ala
305                 310                 315                 320
 
ttg att tct ttg ggt act tca act act gtt ttg att att act aaa aat   1008
Leu Ile Ser Leu Gly Thr Ser Thr Thr Val Leu Ile Ile Thr Lys Asn
                325                 330                 335
 
tat gct cca tct tca caa tat cat tta ttt aaa cat cca act atg cca   1056
Tyr Ala Pro Ser Ser Gln Tyr His Leu Phe Lys His Pro Thr Met Pro
            340                 345                 350
 
gat cat tat atg ggt atg att tgt tat tgt aat ggt tct ttg gct aga   1104
Asp His Tyr Met Gly Met Ile Cys Tyr Cys Asn Gly Ser Leu Ala Arg
        355                 360                 365
 
gaa aaa gta aga gat gaa gtt aat gaa aaa ttt aat gtt gaa gat aaa   1152
Glu Lys Val Arg Asp Glu Val Asn Glu Lys Phe Asn Val Glu Asp Lys
    370                 375                 380
 
aag tct tgg gat aaa ttt aat gaa att ttg gat aaa tca act gat ttt   1200
Lys Ser Trp Asp Lys Phe Asn Glu Ile Leu Asp Lys Ser Thr Asp Phe
385                 390                 395                 400
 
aat aat aag ttg gga att tat ttt cca ttg ggt gaa att gtt cca aat   1248
Asn Asn Lys Leu Gly Ile Tyr Phe Pro Leu Gly Glu Ile Val Pro Asn
                405                 410                 415
 
gct gct gca caa att aag aga tct gtt tta aat tct aaa aat gaa att   1296
Ala Ala Ala Gln Ile Lys Arg Ser Val Leu Asn Ser Lys Asn Glu Ile
            420                 425                 430
 
gtc gat gtt gaa ttg gga gat aaa aat tgg caa cca gag gat gat gta   1344
Val Asp Val Glu Leu Gly Asp Lys Asn Trp Gln Pro Glu Asp Asp Val
        435                 440                 445
 
tct tct att gtt gaa tca caa act cta tct tgt aga ttg aga act ggt   1392
Ser Ser Ile Val Glu Ser Gln Thr Leu Ser Cys Arg Leu Arg Thr Gly
    450                 455                 460
 
cca atg ttg tct aaa tct ggt gat tct tct gct tct tca tct gca tca   1440
Pro Met Leu Ser Lys Ser Gly Asp Ser Ser Ala Ser Ser Ser Ala Ser
465                 470                 475                 480
 
cca caa ccc gaa gga gac ggt act gat ttg cat aag gtt tat caa gat   1488
Pro Gln Pro Glu Gly Asp Gly Thr Asp Leu His Lys Val Tyr Gln Asp
                485                 490                 495
 
ttg gtt aaa aag ttc ggt gat ttg ttt act gat ggt aaa aag caa act   1536
Leu Val Lys Lys Phe Gly Asp Leu Phe Thr Asp Gly Lys Lys Gln Thr
            500                 505                 510
 
ttc gaa tct ttg act gct aga cca aat aga tgt tat tat gtt ggt ggt   1584
Phe Glu Ser Leu Thr Ala Arg Pro Asn Arg Cys Tyr Tyr Val Gly Gly
        515                 520                 525
 
gct tct aat aat ggt tct att att aaa atg ggt tct att ttg gct cca   1632
Ala Ser Asn Asn Gly Ser Ile Ile Lys Met Gly Ser Ile Leu Ala Pro
    530                 535                 540
 
gtt aat ggt aat tat aag gtt gat ata cca aat gct tgt gct ctc gga   1680
Val Asn Gly Asn Tyr Lys Val Asp Ile Pro Asn Ala Cys Ala Leu Gly
545                 550                 555                 560
 
ggt gct tat aaa gcc tct tgg tct tat gaa tgt gaa gct aaa aag gaa   1728
Gly Ala Tyr Lys Ala Ser Trp Ser Tyr Glu Cys Glu Ala Lys Lys Glu
                565                 570                 575
 
tgg ata ggt tat gat caa tac att aat aga ttg ttt gaa gtt tca gat   1776
Trp Ile Gly Tyr Asp Gln Tyr Ile Asn Arg Leu Phe Glu Val Ser Asp
            580                 585                 590
 
gaa atg aat ttg ttc gaa gtt aaa gat aaa tgg ttg gaa tat gct aat   1824
Glu Met Asn Leu Phe Glu Val Lys Asp Lys Trp Leu Glu Tyr Ala Asn
        595                 600                 605
 
ggt gtt ggt atg ttg gct aag atg gaa tca gaa tta aaa cat           1866
Gly Val Gly Met Leu Ala Lys Met Glu Ser Glu Leu Lys His
    610                 615                 620
 


<210> 82
<211> 622
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in E. coli

<400> 82
Met Thr Thr Thr Pro Phe Asp Ala Pro Asp Lys Leu Phe Leu Gly Phe
 1               5                  10                  15      
Asp Leu Ser Thr Gln Gln Leu Lys Ile Ile Val Thr Asp Glu Asn Leu
            20                  25                  30          
Ala Ala Leu Lys Thr Tyr Asn Val Glu Phe Asp Ser Ile Asn Ser Ser
        35                  40                  45              
Val Gln Lys Gly Val Ile Ala Ile Asn Asp Glu Ile Ser Lys Gly Ala
    50                  55                  60                  
Ile Ile Ser Pro Val Tyr Met Trp Leu Asp Ala Leu Asp His Val Phe
65                  70                  75                  80  
Glu Asp Met Lys Lys Asp Gly Phe Pro Phe Asn Lys Val Val Gly Ile
                85                  90                  95      
Ser Gly Ser Cys Gln Gln His Gly Ser Val Tyr Trp Ser Arg Thr Ala
            100                 105                 110         
Glu Lys Val Leu Ser Glu Leu Asp Ala Glu Ser Ser Leu Ser Ser Gln
        115                 120                 125             
Met Arg Ser Ala Phe Thr Phe Lys His Ala Pro Asn Trp Gln Asp His
    130                 135                 140                 
Ser Thr Gly Lys Glu Leu Glu Glu Phe Glu Arg Val Ile Gly Ala Asp
145                 150                 155                 160 
Ala Leu Ala Asp Ile Ser Gly Ser Arg Ala His Tyr Arg Phe Thr Gly
                165                 170                 175     
Leu Gln Ile Arg Lys Leu Ser Thr Arg Phe Lys Pro Glu Lys Tyr Asn
            180                 185                 190         
Arg Thr Ala Arg Ile Ser Leu Val Ser Ser Phe Val Ala Ser Val Leu
        195                 200                 205             
Leu Gly Arg Ile Thr Ser Ile Glu Glu Ala Asp Ala Cys Gly Met Asn
    210                 215                 220                 
Leu Tyr Asp Ile Glu Lys Arg Glu Phe Asn Glu Glu Leu Leu Ala Ile
225                 230                 235                 240 
Ala Ala Gly Val His Pro Glu Leu Asp Gly Val Glu Gln Asp Gly Glu
                245                 250                 255     
Ile Tyr Arg Ala Gly Ile Asn Glu Leu Lys Arg Lys Leu Gly Pro Val
            260                 265                 270         
Lys Pro Ile Thr Tyr Glu Ser Glu Gly Asp Ile Ala Ser Tyr Phe Val
        275                 280                 285             
Thr Arg Tyr Gly Phe Asn Pro Asp Cys Lys Ile Tyr Ser Phe Thr Gly
    290                 295                 300                 
Asp Asn Leu Ala Thr Ile Ile Ser Leu Pro Leu Ala Pro Asn Asp Ala
305                 310                 315                 320 
Leu Ile Ser Leu Gly Thr Ser Thr Thr Val Leu Ile Ile Thr Lys Asn
                325                 330                 335     
Tyr Ala Pro Ser Ser Gln Tyr His Leu Phe Lys His Pro Thr Met Pro
            340                 345                 350         
Asp His Tyr Met Gly Met Ile Cys Tyr Cys Asn Gly Ser Leu Ala Arg
        355                 360                 365             
Glu Lys Val Arg Asp Glu Val Asn Glu Lys Phe Asn Val Glu Asp Lys
    370                 375                 380                 
Lys Ser Trp Asp Lys Phe Asn Glu Ile Leu Asp Lys Ser Thr Asp Phe
385                 390                 395                 400 
Asn Asn Lys Leu Gly Ile Tyr Phe Pro Leu Gly Glu Ile Val Pro Asn
                405                 410                 415     
Ala Ala Ala Gln Ile Lys Arg Ser Val Leu Asn Ser Lys Asn Glu Ile
            420                 425                 430         
Val Asp Val Glu Leu Gly Asp Lys Asn Trp Gln Pro Glu Asp Asp Val
        435                 440                 445             
Ser Ser Ile Val Glu Ser Gln Thr Leu Ser Cys Arg Leu Arg Thr Gly
    450                 455                 460                 
Pro Met Leu Ser Lys Ser Gly Asp Ser Ser Ala Ser Ser Ser Ala Ser
465                 470                 475                 480 
Pro Gln Pro Glu Gly Asp Gly Thr Asp Leu His Lys Val Tyr Gln Asp
                485                 490                 495     
Leu Val Lys Lys Phe Gly Asp Leu Phe Thr Asp Gly Lys Lys Gln Thr
            500                 505                 510         
Phe Glu Ser Leu Thr Ala Arg Pro Asn Arg Cys Tyr Tyr Val Gly Gly
        515                 520                 525             
Ala Ser Asn Asn Gly Ser Ile Ile Lys Met Gly Ser Ile Leu Ala Pro
    530                 535                 540                 
Val Asn Gly Asn Tyr Lys Val Asp Ile Pro Asn Ala Cys Ala Leu Gly
545                 550                 555                 560 
Gly Ala Tyr Lys Ala Ser Trp Ser Tyr Glu Cys Glu Ala Lys Lys Glu
                565                 570                 575     
Trp Ile Gly Tyr Asp Gln Tyr Ile Asn Arg Leu Phe Glu Val Ser Asp
            580                 585                 590         
Glu Met Asn Leu Phe Glu Val Lys Asp Lys Trp Leu Glu Tyr Ala Asn
        595                 600                 605             
Gly Val Gly Met Leu Ala Lys Met Glu Ser Glu Leu Lys His
    610                 615                 620         


<210> 83
<211> 1888
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in E. coli

<220> 
<221> CDS            
<222> (12)...(1878)

<400> 83
tactcaagct t atg act act act cca ttt gat gct cca gat aaa ttg ttt  50
             Met Thr Thr Thr Pro Phe Asp Ala Pro Asp Lys Leu Phe
              1               5                   10
 
ttg ggt ttt gat ttg tca act caa caa tta aaa att att gtt act gat   98
Leu Gly Phe Asp Leu Ser Thr Gln Gln Leu Lys Ile Ile Val Thr Asp
     15                  20                  25
 
gaa aat tta gct gct tta aaa act tat aat gtt gaa ttt gat tct att   146
Glu Asn Leu Ala Ala Leu Lys Thr Tyr Asn Val Glu Phe Asp Ser Ile
 30                  35                  40                  45
 
aat tct tct gtt caa aaa ggt gta att gct att aat gat gaa att tct   194
Asn Ser Ser Val Gln Lys Gly Val Ile Ala Ile Asn Asp Glu Ile Ser
                 50                  55                  60
 
aaa ggt gct att att tca cca gtt tat atg tgg ttg gac gct tta gat   242
Lys Gly Ala Ile Ile Ser Pro Val Tyr Met Trp Leu Asp Ala Leu Asp
             65                  70                  75
 
cat gta ttt gaa gat atg aaa aag gac ggc ttt cca ttt aat aaa gta   290
His Val Phe Glu Asp Met Lys Lys Asp Gly Phe Pro Phe Asn Lys Val
         80                  85                  90
 
gtt gga att tct ggt tct tgt caa caa cat ggt tct gtt tat tgg tct   338
Val Gly Ile Ser Gly Ser Cys Gln Gln His Gly Ser Val Tyr Trp Ser
     95                 100                 105
 
aga act gct gaa aaa gta ttg tct gaa ttg gat gct gaa tct tct ttg   386
Arg Thr Ala Glu Lys Val Leu Ser Glu Leu Asp Ala Glu Ser Ser Leu
110                 115                 120                 125
 
tct tca caa atg aga tct gct ttt act ttt aaa cat gct cca aat tgg   434
Ser Ser Gln Met Arg Ser Ala Phe Thr Phe Lys His Ala Pro Asn Trp
                130                 135                 140
 
caa gat cat tca act ggt aaa gaa ttg gaa gaa ttt gaa aga gta att   482
Gln Asp His Ser Thr Gly Lys Glu Leu Glu Glu Phe Glu Arg Val Ile
            145                 150                 155
 
ggt gct gat gct ttg gct gat ata tct ggt tct agg gct cat tat aga   530
Gly Ala Asp Ala Leu Ala Asp Ile Ser Gly Ser Arg Ala His Tyr Arg
        160                 165                 170
 
ttt act ggt ttg caa att aga aaa ttg tca act aga ttt aaa cca gaa   578
Phe Thr Gly Leu Gln Ile Arg Lys Leu Ser Thr Arg Phe Lys Pro Glu
    175                 180                 185
 
aaa tat aat aga aca gcg aga att tct ttg gtt tca tct ttt gta gct   626
Lys Tyr Asn Arg Thr Ala Arg Ile Ser Leu Val Ser Ser Phe Val Ala
190                 195                 200                 205
 
tct gtt ttg ttg ggt aga att aca tct att gaa gag gct gat gct tgt   674
Ser Val Leu Leu Gly Arg Ile Thr Ser Ile Glu Glu Ala Asp Ala Cys
                210                 215                 220
 
ggt atg aat ttg tat gac att gaa aaa cgt gaa ttt aat gaa gaa ttg   722
Gly Met Asn Leu Tyr Asp Ile Glu Lys Arg Glu Phe Asn Glu Glu Leu
            225                 230                 235
 
ttg gct att gct gcg ggt gtt cat cca gaa tta gat ggt gtt gaa caa   770
Leu Ala Ile Ala Ala Gly Val His Pro Glu Leu Asp Gly Val Glu Gln
        240                 245                 250
 
gat gga gaa att tat aga gct gga att aat gaa tta aaa aga aaa ttg   818
Asp Gly Glu Ile Tyr Arg Ala Gly Ile Asn Glu Leu Lys Arg Lys Leu
    255                 260                 265
 
ggt cca gtt aaa ccg ata act tat gaa tct gaa ggt gat ata gct tct   866
Gly Pro Val Lys Pro Ile Thr Tyr Glu Ser Glu Gly Asp Ile Ala Ser
270                 275                 280                 285
 
tat ttt gta act aga tat ggt ttt aat cca gat tgt aaa att tat tct   914
Tyr Phe Val Thr Arg Tyr Gly Phe Asn Pro Asp Cys Lys Ile Tyr Ser
                290                 295                 300
 
ttt act ggt gat aat ttg gcc act att att tct ttg ccc tta gct cca   962
Phe Thr Gly Asp Asn Leu Ala Thr Ile Ile Ser Leu Pro Leu Ala Pro
            305                 310                 315
 
aat gat gct ttg att tct ttg ggt act tca act act gtt ttg att att   1010
Asn Asp Ala Leu Ile Ser Leu Gly Thr Ser Thr Thr Val Leu Ile Ile
        320                 325                 330
 
act aaa aat tat gct cca tct tca caa tat cat tta ttt aaa cat cca   1058
Thr Lys Asn Tyr Ala Pro Ser Ser Gln Tyr His Leu Phe Lys His Pro
    335                 340                 345
 
act atg cca gat cat tat atg ggt atg att tgt tat tgt aat ggt tct   1106
Thr Met Pro Asp His Tyr Met Gly Met Ile Cys Tyr Cys Asn Gly Ser
350                 355                 360                 365
 
ttg gct aga gaa aaa gta aga gat gaa gtt aat gaa aaa ttt aat gtt   1154
Leu Ala Arg Glu Lys Val Arg Asp Glu Val Asn Glu Lys Phe Asn Val
                370                 375                 380
 
gaa gat aaa aag tct tgg gat aaa ttt aat gaa att ttg gat aaa tca   1202
Glu Asp Lys Lys Ser Trp Asp Lys Phe Asn Glu Ile Leu Asp Lys Ser
            385                 390                 395
 
act gat ttt aat aat aag ttg gga att tat ttt cca ttg ggt gaa att   1250
Thr Asp Phe Asn Asn Lys Leu Gly Ile Tyr Phe Pro Leu Gly Glu Ile
        400                 405                 410
 
gtt cca aat gct gct gca caa att aag aga tct gtt tta aat tct aaa   1298
Val Pro Asn Ala Ala Ala Gln Ile Lys Arg Ser Val Leu Asn Ser Lys
    415                 420                 425
 
aat gaa att gtc gat gtt gaa ttg gga gat aaa aat tgg caa cca gag   1346
Asn Glu Ile Val Asp Val Glu Leu Gly Asp Lys Asn Trp Gln Pro Glu
430                 435                 440                 445
 
gat gat gta tct tct att gtt gaa tca caa act cta tct tgt aga ttg   1394
Asp Asp Val Ser Ser Ile Val Glu Ser Gln Thr Leu Ser Cys Arg Leu
                450                 455                 460
 
aga act ggt cca atg ttg tct aaa tct ggt gat tct tct gct tct tca   1442
Arg Thr Gly Pro Met Leu Ser Lys Ser Gly Asp Ser Ser Ala Ser Ser
            465                 470                 475
 
tct gca tca cca caa ccc gaa gga gac ggt act gat ttg cat aag gtt   1490
Ser Ala Ser Pro Gln Pro Glu Gly Asp Gly Thr Asp Leu His Lys Val
        480                 485                 490
 
tat caa gat ttg gtt aaa aag ttc ggt gat ttg ttt act gat ggt aaa   1538
Tyr Gln Asp Leu Val Lys Lys Phe Gly Asp Leu Phe Thr Asp Gly Lys
    495                 500                 505
 
aag caa act ttc gaa tct ttg act gct aga cca aat aga tgt tat tat   1586
Lys Gln Thr Phe Glu Ser Leu Thr Ala Arg Pro Asn Arg Cys Tyr Tyr
510                 515                 520                 525
 
gtt ggt ggt gct tct aat aat ggt tct att att aaa atg ggt tct att   1634
Val Gly Gly Ala Ser Asn Asn Gly Ser Ile Ile Lys Met Gly Ser Ile
                530                 535                 540
 
ttg gct cca gtt aat ggt aat tat aag gtt gat ata cca aat gct tgt   1682
Leu Ala Pro Val Asn Gly Asn Tyr Lys Val Asp Ile Pro Asn Ala Cys
            545                 550                 555
 
gct ctc gga ggt gct tat aaa gcc tct tgg tct tat gaa tgt gaa gct   1730
Ala Leu Gly Gly Ala Tyr Lys Ala Ser Trp Ser Tyr Glu Cys Glu Ala
        560                 565                 570
 
aaa aag gaa tgg ata ggt tat gat caa tac att aat aga ttg ttt gaa   1778
Lys Lys Glu Trp Ile Gly Tyr Asp Gln Tyr Ile Asn Arg Leu Phe Glu
    575                 580                 585
 
gtt tca gat gaa atg aat ttg ttc gaa gtt aaa gat aaa tgg ttg gaa   1826
Val Ser Asp Glu Met Asn Leu Phe Glu Val Lys Asp Lys Trp Leu Glu
590                 595                 600                 605
 
tat gct aat ggt gtt ggt atg ttg gct aag atg gaa tca gaa tta aaa   1874
Tyr Ala Asn Gly Val Gly Met Leu Ala Lys Met Glu Ser Glu Leu Lys
                610                 615                 620
 
cat g aattccgatg                                                  1888
His

 

<210> 84
<211> 622
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in E. coli

<400> 84
Met Thr Thr Thr Pro Phe Asp Ala Pro Asp Lys Leu Phe Leu Gly Phe
 1               5                  10                  15      
Asp Leu Ser Thr Gln Gln Leu Lys Ile Ile Val Thr Asp Glu Asn Leu
            20                  25                  30          
Ala Ala Leu Lys Thr Tyr Asn Val Glu Phe Asp Ser Ile Asn Ser Ser
        35                  40                  45              
Val Gln Lys Gly Val Ile Ala Ile Asn Asp Glu Ile Ser Lys Gly Ala
    50                  55                  60                  
Ile Ile Ser Pro Val Tyr Met Trp Leu Asp Ala Leu Asp His Val Phe
65                  70                  75                  80  
Glu Asp Met Lys Lys Asp Gly Phe Pro Phe Asn Lys Val Val Gly Ile
                85                  90                  95      
Ser Gly Ser Cys Gln Gln His Gly Ser Val Tyr Trp Ser Arg Thr Ala
            100                 105                 110         
Glu Lys Val Leu Ser Glu Leu Asp Ala Glu Ser Ser Leu Ser Ser Gln
        115                 120                 125             
Met Arg Ser Ala Phe Thr Phe Lys His Ala Pro Asn Trp Gln Asp His
    130                 135                 140                 
Ser Thr Gly Lys Glu Leu Glu Glu Phe Glu Arg Val Ile Gly Ala Asp
145                 150                 155                 160 
Ala Leu Ala Asp Ile Ser Gly Ser Arg Ala His Tyr Arg Phe Thr Gly
                165                 170                 175     
Leu Gln Ile Arg Lys Leu Ser Thr Arg Phe Lys Pro Glu Lys Tyr Asn
            180                 185                 190         
Arg Thr Ala Arg Ile Ser Leu Val Ser Ser Phe Val Ala Ser Val Leu
        195                 200                 205             
Leu Gly Arg Ile Thr Ser Ile Glu Glu Ala Asp Ala Cys Gly Met Asn
    210                 215                 220                 
Leu Tyr Asp Ile Glu Lys Arg Glu Phe Asn Glu Glu Leu Leu Ala Ile
225                 230                 235                 240 
Ala Ala Gly Val His Pro Glu Leu Asp Gly Val Glu Gln Asp Gly Glu
                245                 250                 255     
Ile Tyr Arg Ala Gly Ile Asn Glu Leu Lys Arg Lys Leu Gly Pro Val
            260                 265                 270         
Lys Pro Ile Thr Tyr Glu Ser Glu Gly Asp Ile Ala Ser Tyr Phe Val
        275                 280                 285             
Thr Arg Tyr Gly Phe Asn Pro Asp Cys Lys Ile Tyr Ser Phe Thr Gly
    290                 295                 300                 
Asp Asn Leu Ala Thr Ile Ile Ser Leu Pro Leu Ala Pro Asn Asp Ala
305                 310                 315                 320 
Leu Ile Ser Leu Gly Thr Ser Thr Thr Val Leu Ile Ile Thr Lys Asn
                325                 330                 335     
Tyr Ala Pro Ser Ser Gln Tyr His Leu Phe Lys His Pro Thr Met Pro
            340                 345                 350         
Asp His Tyr Met Gly Met Ile Cys Tyr Cys Asn Gly Ser Leu Ala Arg
        355                 360                 365             
Glu Lys Val Arg Asp Glu Val Asn Glu Lys Phe Asn Val Glu Asp Lys
    370                 375                 380                 
Lys Ser Trp Asp Lys Phe Asn Glu Ile Leu Asp Lys Ser Thr Asp Phe
385                 390                 395                 400 
Asn Asn Lys Leu Gly Ile Tyr Phe Pro Leu Gly Glu Ile Val Pro Asn
                405                 410                 415     
Ala Ala Ala Gln Ile Lys Arg Ser Val Leu Asn Ser Lys Asn Glu Ile
            420                 425                 430         
Val Asp Val Glu Leu Gly Asp Lys Asn Trp Gln Pro Glu Asp Asp Val
        435                 440                 445             
Ser Ser Ile Val Glu Ser Gln Thr Leu Ser Cys Arg Leu Arg Thr Gly
    450                 455                 460                 
Pro Met Leu Ser Lys Ser Gly Asp Ser Ser Ala Ser Ser Ser Ala Ser
465                 470                 475                 480 
Pro Gln Pro Glu Gly Asp Gly Thr Asp Leu His Lys Val Tyr Gln Asp
                485                 490                 495     
Leu Val Lys Lys Phe Gly Asp Leu Phe Thr Asp Gly Lys Lys Gln Thr
            500                 505                 510         
Phe Glu Ser Leu Thr Ala Arg Pro Asn Arg Cys Tyr Tyr Val Gly Gly
        515                 520                 525             
Ala Ser Asn Asn Gly Ser Ile Ile Lys Met Gly Ser Ile Leu Ala Pro
    530                 535                 540                 
Val Asn Gly Asn Tyr Lys Val Asp Ile Pro Asn Ala Cys Ala Leu Gly
545                 550                 555                 560 
Gly Ala Tyr Lys Ala Ser Trp Ser Tyr Glu Cys Glu Ala Lys Lys Glu
                565                 570                 575     
Trp Ile Gly Tyr Asp Gln Tyr Ile Asn Arg Leu Phe Glu Val Ser Asp
            580                 585                 590         
Glu Met Asn Leu Phe Glu Val Lys Asp Lys Trp Leu Glu Tyr Ala Asn
        595                 600                 605             
Gly Val Gly Met Leu Ala Lys Met Glu Ser Glu Leu Lys His
    610                 615                 620         


<210> 85
<211> 1894
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in E. coli

<220> 
<221> CDS            
<222> (15)...(1880)

<400> 85
gaatactcca tatg atg act act act cca ttt gat gct cca gat aaa ttg   50
                Met Thr Thr Thr Pro Phe Asp Ala Pro Asp Lys Leu
                 1               5                   10
 
ttt ttg ggt ttt gat ttg tca act caa caa tta aaa att att gtt act   98
Phe Leu Gly Phe Asp Leu Ser Thr Gln Gln Leu Lys Ile Ile Val Thr
         15                  20                  25
 
gat gaa aat tta gct gct tta aaa act tat aat gtt gaa ttt gat tct   146
Asp Glu Asn Leu Ala Ala Leu Lys Thr Tyr Asn Val Glu Phe Asp Ser
     30                  35                  40
 
att aat tct tct gtt caa aaa ggt gta att gct att aat gat gaa att   194
Ile Asn Ser Ser Val Gln Lys Gly Val Ile Ala Ile Asn Asp Glu Ile
 45                  50                  55                  60
 
tct aaa ggt gct att att tca cca gtt tat atg tgg ttg gac gct tta   242
Ser Lys Gly Ala Ile Ile Ser Pro Val Tyr Met Trp Leu Asp Ala Leu
                 65                  70                  75
 
gat cat gta ttt gaa gat atg aaa aag gac ggc ttt cca ttt aat aaa   290
Asp His Val Phe Glu Asp Met Lys Lys Asp Gly Phe Pro Phe Asn Lys
             80                  85                  90
 
gta gtt gga att tct ggt tct tgt caa caa cat ggt tct gtt tat tgg   338
Val Val Gly Ile Ser Gly Ser Cys Gln Gln His Gly Ser Val Tyr Trp
         95                 100                 105
 
tct aga act gct gaa aaa gta ttg tct gaa ttg gat gct gaa tct tct   386
Ser Arg Thr Ala Glu Lys Val Leu Ser Glu Leu Asp Ala Glu Ser Ser
    110                 115                 120
 
ttg tct tca caa atg aga tct gct ttt act ttt aaa cat gct cca aat   434
Leu Ser Ser Gln Met Arg Ser Ala Phe Thr Phe Lys His Ala Pro Asn
125                 130                 135                 140
 
tgg caa gat cat tca act ggt aaa gaa ttg gaa gaa ttt gaa aga gta   482
Trp Gln Asp His Ser Thr Gly Lys Glu Leu Glu Glu Phe Glu Arg Val
                145                 150                 155
 
att ggt gct gat gct ttg gct gat ata tct ggt tct agg gct cat tat   530
Ile Gly Ala Asp Ala Leu Ala Asp Ile Ser Gly Ser Arg Ala His Tyr
            160                 165                 170
 
aga ttt act ggt ttg caa att aga aaa ttg tca act aga ttt aaa cca   578
Arg Phe Thr Gly Leu Gln Ile Arg Lys Leu Ser Thr Arg Phe Lys Pro
        175                 180                 185
 
gaa aaa tat aat aga aca gcg aga att tct ttg gtt tca tct ttt gta   626
Glu Lys Tyr Asn Arg Thr Ala Arg Ile Ser Leu Val Ser Ser Phe Val
    190                 195                 200
 
gct tct gtt ttg ttg ggt aga att aca tct att gaa gag gct gat gct   674
Ala Ser Val Leu Leu Gly Arg Ile Thr Ser Ile Glu Glu Ala Asp Ala
205                 210                 215                 220
 
tgt ggt atg aat ttg tat gac att gaa aaa cgt gaa ttt aat gaa gaa   722
Cys Gly Met Asn Leu Tyr Asp Ile Glu Lys Arg Glu Phe Asn Glu Glu
                225                 230                 235
 
ttg ttg gct att gct gcg ggt gtt cat cca gaa tta gat ggt gtt gaa   770
Leu Leu Ala Ile Ala Ala Gly Val His Pro Glu Leu Asp Gly Val Glu
            240                 245                 250
 
caa gat gga gaa att tat aga gct gga att aat gaa tta aaa aga aaa   818
Gln Asp Gly Glu Ile Tyr Arg Ala Gly Ile Asn Glu Leu Lys Arg Lys
        255                 260                 265
 
ttg ggt cca gtt aaa ccg ata act tat gaa tct gaa ggt gat ata gct   866
Leu Gly Pro Val Lys Pro Ile Thr Tyr Glu Ser Glu Gly Asp Ile Ala
    270                 275                 280
 
tct tat ttt gta act aga tat ggt ttt aat cca gat tgt aaa att tat   914
Ser Tyr Phe Val Thr Arg Tyr Gly Phe Asn Pro Asp Cys Lys Ile Tyr
285                 290                 295                 300
 
tct ttt act ggt gat aat ttg gcc act att att tct ttg ccc tta gct   962
Ser Phe Thr Gly Asp Asn Leu Ala Thr Ile Ile Ser Leu Pro Leu Ala
                305                 310                 315
 
cca aat gat gct ttg att tct ttg ggt act tca act act gtt ttg att   1010
Pro Asn Asp Ala Leu Ile Ser Leu Gly Thr Ser Thr Thr Val Leu Ile
            320                 325                 330
 
att act aaa aat tat gct cca tct tca caa tat cat tta ttt aaa cat   1058
Ile Thr Lys Asn Tyr Ala Pro Ser Ser Gln Tyr His Leu Phe Lys His
        335                 340                 345
 
cca act atg cca gat cat tat atg ggt atg att tgt tat tgt aat ggt   1106
Pro Thr Met Pro Asp His Tyr Met Gly Met Ile Cys Tyr Cys Asn Gly
    350                 355                 360
 
tct ttg gct aga gaa aaa gta aga gat gaa gtt aat gaa aaa ttt aat   1154
Ser Leu Ala Arg Glu Lys Val Arg Asp Glu Val Asn Glu Lys Phe Asn
365                 370                 375                 380
 
gtt gaa gat aaa aag tct tgg gat aaa ttt aat gaa att ttg gat aaa   1202
Val Glu Asp Lys Lys Ser Trp Asp Lys Phe Asn Glu Ile Leu Asp Lys
                385                 390                 395
 
tca act gat ttt aat aat aag ttg gga att tat ttt cca ttg ggt gaa   1250
Ser Thr Asp Phe Asn Asn Lys Leu Gly Ile Tyr Phe Pro Leu Gly Glu
            400                 405                 410
 
att gtt cca aat gct gct gca caa att aag aga tct gtt tta aat tct   1298
Ile Val Pro Asn Ala Ala Ala Gln Ile Lys Arg Ser Val Leu Asn Ser
        415                 420                 425
 
aaa aat gaa att gtc gat gtt gaa ttg gga gat aaa aat tgg caa cca   1346
Lys Asn Glu Ile Val Asp Val Glu Leu Gly Asp Lys Asn Trp Gln Pro
    430                 435                 440
 
gag gat gat gta tct tct att gtt gaa tca caa act cta tct tgt aga   1394
Glu Asp Asp Val Ser Ser Ile Val Glu Ser Gln Thr Leu Ser Cys Arg
445                 450                 455                 460
 
ttg aga act ggt cca atg ttg tct aaa tct ggt gat tct tct gct tct   1442
Leu Arg Thr Gly Pro Met Leu Ser Lys Ser Gly Asp Ser Ser Ala Ser
                465                 470                 475
 
tca tct gca tca cca caa ccc gaa gga gac ggt act gat ttg cat aag   1490
Ser Ser Ala Ser Pro Gln Pro Glu Gly Asp Gly Thr Asp Leu His Lys
            480                 485                 490
 
gtt tat caa gat ttg gtt aaa aag ttc ggt gat ttg ttt act gat ggt   1538
Val Tyr Gln Asp Leu Val Lys Lys Phe Gly Asp Leu Phe Thr Asp Gly
        495                 500                 505
 
aaa aag caa act ttc gaa tct ttg act gct aga cca aat aga tgt tat   1586
Lys Lys Gln Thr Phe Glu Ser Leu Thr Ala Arg Pro Asn Arg Cys Tyr
    510                 515                 520
 
tat gtt ggt ggt gct tct aat aat ggt tct att att aaa atg ggt tct   1634
Tyr Val Gly Gly Ala Ser Asn Asn Gly Ser Ile Ile Lys Met Gly Ser
525                 530                 535                 540
 
att ttg gct cca gtt aat ggt aat tat aag gtt gat ata cca aat gct   1682
Ile Leu Ala Pro Val Asn Gly Asn Tyr Lys Val Asp Ile Pro Asn Ala
                545                 550                 555
 
tgt gct ctc gga ggt gct tat aaa gcc tct tgg tct tat gaa tgt gaa   1730
Cys Ala Leu Gly Gly Ala Tyr Lys Ala Ser Trp Ser Tyr Glu Cys Glu
            560                 565                 570
 
gct aaa aag gaa tgg ata ggt tat gat caa tac att aat aga ttg ttt   1778
Ala Lys Lys Glu Trp Ile Gly Tyr Asp Gln Tyr Ile Asn Arg Leu Phe
        575                 580                 585
 
gaa gtt tca gat gaa atg aat ttg ttc gaa gtt aaa gat aaa tgg ttg   1826
Glu Val Ser Asp Glu Met Asn Leu Phe Glu Val Lys Asp Lys Trp Leu
    590                 595                 600
 
gaa tat gct aat ggt gtt ggt atg ttg gct aag atg gaa tca gaa tta   1874
Glu Tyr Ala Asn Gly Val Gly Met Leu Ala Lys Met Glu Ser Glu Leu
605                 610                 615                 620
 
aaa cat actagtcgat gcct                                           1894
Lys His

 

<210> 86
<211> 622
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in E. coli

<400> 86
Met Thr Thr Thr Pro Phe Asp Ala Pro Asp Lys Leu Phe Leu Gly Phe
 1               5                  10                  15      
Asp Leu Ser Thr Gln Gln Leu Lys Ile Ile Val Thr Asp Glu Asn Leu
            20                  25                  30          
Ala Ala Leu Lys Thr Tyr Asn Val Glu Phe Asp Ser Ile Asn Ser Ser
        35                  40                  45              
Val Gln Lys Gly Val Ile Ala Ile Asn Asp Glu Ile Ser Lys Gly Ala
    50                  55                  60                  
Ile Ile Ser Pro Val Tyr Met Trp Leu Asp Ala Leu Asp His Val Phe
65                  70                  75                  80  
Glu Asp Met Lys Lys Asp Gly Phe Pro Phe Asn Lys Val Val Gly Ile
                85                  90                  95      
Ser Gly Ser Cys Gln Gln His Gly Ser Val Tyr Trp Ser Arg Thr Ala
            100                 105                 110         
Glu Lys Val Leu Ser Glu Leu Asp Ala Glu Ser Ser Leu Ser Ser Gln
        115                 120                 125             
Met Arg Ser Ala Phe Thr Phe Lys His Ala Pro Asn Trp Gln Asp His
    130                 135                 140                 
Ser Thr Gly Lys Glu Leu Glu Glu Phe Glu Arg Val Ile Gly Ala Asp
145                 150                 155                 160 
Ala Leu Ala Asp Ile Ser Gly Ser Arg Ala His Tyr Arg Phe Thr Gly
                165                 170                 175     
Leu Gln Ile Arg Lys Leu Ser Thr Arg Phe Lys Pro Glu Lys Tyr Asn
            180                 185                 190         
Arg Thr Ala Arg Ile Ser Leu Val Ser Ser Phe Val Ala Ser Val Leu
        195                 200                 205             
Leu Gly Arg Ile Thr Ser Ile Glu Glu Ala Asp Ala Cys Gly Met Asn
    210                 215                 220                 
Leu Tyr Asp Ile Glu Lys Arg Glu Phe Asn Glu Glu Leu Leu Ala Ile
225                 230                 235                 240 
Ala Ala Gly Val His Pro Glu Leu Asp Gly Val Glu Gln Asp Gly Glu
                245                 250                 255     
Ile Tyr Arg Ala Gly Ile Asn Glu Leu Lys Arg Lys Leu Gly Pro Val
            260                 265                 270         
Lys Pro Ile Thr Tyr Glu Ser Glu Gly Asp Ile Ala Ser Tyr Phe Val
        275                 280                 285             
Thr Arg Tyr Gly Phe Asn Pro Asp Cys Lys Ile Tyr Ser Phe Thr Gly
    290                 295                 300                 
Asp Asn Leu Ala Thr Ile Ile Ser Leu Pro Leu Ala Pro Asn Asp Ala
305                 310                 315                 320 
Leu Ile Ser Leu Gly Thr Ser Thr Thr Val Leu Ile Ile Thr Lys Asn
                325                 330                 335     
Tyr Ala Pro Ser Ser Gln Tyr His Leu Phe Lys His Pro Thr Met Pro
            340                 345                 350         
Asp His Tyr Met Gly Met Ile Cys Tyr Cys Asn Gly Ser Leu Ala Arg
        355                 360                 365             
Glu Lys Val Arg Asp Glu Val Asn Glu Lys Phe Asn Val Glu Asp Lys
    370                 375                 380                 
Lys Ser Trp Asp Lys Phe Asn Glu Ile Leu Asp Lys Ser Thr Asp Phe
385                 390                 395                 400 
Asn Asn Lys Leu Gly Ile Tyr Phe Pro Leu Gly Glu Ile Val Pro Asn
                405                 410                 415     
Ala Ala Ala Gln Ile Lys Arg Ser Val Leu Asn Ser Lys Asn Glu Ile
            420                 425                 430         
Val Asp Val Glu Leu Gly Asp Lys Asn Trp Gln Pro Glu Asp Asp Val
        435                 440                 445             
Ser Ser Ile Val Glu Ser Gln Thr Leu Ser Cys Arg Leu Arg Thr Gly
    450                 455                 460                 
Pro Met Leu Ser Lys Ser Gly Asp Ser Ser Ala Ser Ser Ser Ala Ser
465                 470                 475                 480 
Pro Gln Pro Glu Gly Asp Gly Thr Asp Leu His Lys Val Tyr Gln Asp
                485                 490                 495     
Leu Val Lys Lys Phe Gly Asp Leu Phe Thr Asp Gly Lys Lys Gln Thr
            500                 505                 510         
Phe Glu Ser Leu Thr Ala Arg Pro Asn Arg Cys Tyr Tyr Val Gly Gly
        515                 520                 525             
Ala Ser Asn Asn Gly Ser Ile Ile Lys Met Gly Ser Ile Leu Ala Pro
    530                 535                 540                 
Val Asn Gly Asn Tyr Lys Val Asp Ile Pro Asn Ala Cys Ala Leu Gly
545                 550                 555                 560 
Gly Ala Tyr Lys Ala Ser Trp Ser Tyr Glu Cys Glu Ala Lys Lys Glu
                565                 570                 575     
Trp Ile Gly Tyr Asp Gln Tyr Ile Asn Arg Leu Phe Glu Val Ser Asp
            580                 585                 590         
Glu Met Asn Leu Phe Glu Val Lys Asp Lys Trp Leu Glu Tyr Ala Asn
        595                 600                 605             
Gly Val Gly Met Leu Ala Lys Met Glu Ser Glu Leu Lys His
    610                 615                 620         


<210> 87
<211> 1866
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in P. pastoris

<220> 
<221> CDS            
<222> (1)...(1866)

<400> 87
atg act act act cca ttt gat gct cca gat aaa ttg ttt ttg gga ttt   48
Met Thr Thr Thr Pro Phe Asp Ala Pro Asp Lys Leu Phe Leu Gly Phe
 1               5                   10                  15
 
gat ttg tct act caa caa tta aaa att att gtt act gat gaa aat ttg   96
Asp Leu Ser Thr Gln Gln Leu Lys Ile Ile Val Thr Asp Glu Asn Leu
             20                  25                  30
 
gct gct tta aaa act tat aat gtt gaa ttt gat tct att aat tct tct   144
Ala Ala Leu Lys Thr Tyr Asn Val Glu Phe Asp Ser Ile Asn Ser Ser
         35                  40                  45
 
gtt caa aaa gga gtt att gct att aat gat gaa att tct aaa gga gct   192
Val Gln Lys Gly Val Ile Ala Ile Asn Asp Glu Ile Ser Lys Gly Ala
     50                  55                  60
 
att att tct cca gtt tat atg tgg tta gac gct ttg gat cat gtt ttt   240
Ile Ile Ser Pro Val Tyr Met Trp Leu Asp Ala Leu Asp His Val Phe
 65                  70                  75                  80
 
gag gat atg aaa aag gac gga ttt cca ttt aat aaa gtt gtt gga att   288
Glu Asp Met Lys Lys Asp Gly Phe Pro Phe Asn Lys Val Val Gly Ile
                 85                  90                  95
 
tct gga tct tgt cag caa cat gga tct gtt tat tgg tct aga act gct   336
Ser Gly Ser Cys Gln Gln His Gly Ser Val Tyr Trp Ser Arg Thr Ala
            100                 105                 110
 
gaa aaa gtt ttg tct gaa ttg gat gct gaa tct tct tta tct tct caa   384
Glu Lys Val Leu Ser Glu Leu Asp Ala Glu Ser Ser Leu Ser Ser Gln
        115                 120                 125
 
atg aga tct gct ttt act ttt aaa cac gct cct aat tgg caa gat cat   432
Met Arg Ser Ala Phe Thr Phe Lys His Ala Pro Asn Trp Gln Asp His
    130                 135                 140
 
tct act gga aaa gaa tta gaa gaa ttt gag aga gtt att gga gct gat   480
Ser Thr Gly Lys Glu Leu Glu Glu Phe Glu Arg Val Ile Gly Ala Asp
145                 150                 155                 160
 
gct ttg gct gac att tct gga tct aga gca cat tat aga ttt act gga   528
Ala Leu Ala Asp Ile Ser Gly Ser Arg Ala His Tyr Arg Phe Thr Gly
                165                 170                 175
 
ttg caa att aga aaa ttg tct act aga ttt aaa cct gag aaa tat aat   576
Leu Gln Ile Arg Lys Leu Ser Thr Arg Phe Lys Pro Glu Lys Tyr Asn
            180                 185                 190
 
aga act gct aga att tct tta gtt tct tct ttt gtt gct tct gtt ttg   624
Arg Thr Ala Arg Ile Ser Leu Val Ser Ser Phe Val Ala Ser Val Leu
        195                 200                 205
 
ttg gga agg att act tct att gag gag gct gat gct tgt gga atg aat   672
Leu Gly Arg Ile Thr Ser Ile Glu Glu Ala Asp Ala Cys Gly Met Asn
    210                 215                 220
 
ttg tat gac att gaa aaa cgt gaa ttt aat gaa gaa ttg ttg gct att   720
Leu Tyr Asp Ile Glu Lys Arg Glu Phe Asn Glu Glu Leu Leu Ala Ile
225                 230                 235                 240
 
gct gcc ggt gtt cat cca gaa tta gat gga gtt gaa caa gat ggg gaa   768
Ala Ala Gly Val His Pro Glu Leu Asp Gly Val Glu Gln Asp Gly Glu
                245                 250                 255
 
att tat aga gct gga att aat gaa tta aaa aga aaa ttg gga cca gtt   816
Ile Tyr Arg Ala Gly Ile Asn Glu Leu Lys Arg Lys Leu Gly Pro Val
            260                 265                 270
 
aaa cct att act tat gaa tct gaa gga gat ata gct tct tat ttt gtt   864
Lys Pro Ile Thr Tyr Glu Ser Glu Gly Asp Ile Ala Ser Tyr Phe Val
        275                 280                 285
 
act aga tat ggt ttt aat cca gat tgt aaa att tat tct ttt act gga   912
Thr Arg Tyr Gly Phe Asn Pro Asp Cys Lys Ile Tyr Ser Phe Thr Gly
    290                 295                 300
 
gat aat ttg gct act att att tca ttg cct ttg gct cca aat gat gct   960
Asp Asn Leu Ala Thr Ile Ile Ser Leu Pro Leu Ala Pro Asn Asp Ala
305                 310                 315                 320
 
ttg att tca ttg gga aca tct act act gtt ttg att att act aaa aat   1008
Leu Ile Ser Leu Gly Thr Ser Thr Thr Val Leu Ile Ile Thr Lys Asn
                325                 330                 335
 
tat gct cca tct tct caa tat cat ttg ttt aag cat cca act atg cca   1056
Tyr Ala Pro Ser Ser Gln Tyr His Leu Phe Lys His Pro Thr Met Pro
            340                 345                 350
 
gat cat tat atg gga atg att tgt tat tgt aat gga tct tta gct aga   1104
Asp His Tyr Met Gly Met Ile Cys Tyr Cys Asn Gly Ser Leu Ala Arg
        355                 360                 365
 
gaa aaa gtt aga gat gaa gtt aat gaa aaa ttt aat gtt gaa gat aaa   1152
Glu Lys Val Arg Asp Glu Val Asn Glu Lys Phe Asn Val Glu Asp Lys
    370                 375                 380
 
aag tct tgg gat aaa ttt aat gaa att ttg gat aaa tca act gat ttt   1200
Lys Ser Trp Asp Lys Phe Asn Glu Ile Leu Asp Lys Ser Thr Asp Phe
385                 390                 395                 400
 
aat aat aag ttg gga att tat ttt cca ttg gga gaa att gtt cca aat   1248
Asn Asn Lys Leu Gly Ile Tyr Phe Pro Leu Gly Glu Ile Val Pro Asn
                405                 410                 415
 
gca gca gct caa ata aag aga tct gtt tta aat tct aaa aat gaa att   1296
Ala Ala Ala Gln Ile Lys Arg Ser Val Leu Asn Ser Lys Asn Glu Ile
            420                 425                 430
 
gtt gat gtt gaa tta gga gat aaa aat tgg caa cca gaa gat gat gtt   1344
Val Asp Val Glu Leu Gly Asp Lys Asn Trp Gln Pro Glu Asp Asp Val
        435                 440                 445
 
tct agt att gtt gaa tct caa act tta tct tgt aga ttg aga act gga   1392
Ser Ser Ile Val Glu Ser Gln Thr Leu Ser Cys Arg Leu Arg Thr Gly
    450                 455                 460
 
cca atg ttg tct aaa tct gga gat tct tct gca tct tct agt gct agc   1440
Pro Met Leu Ser Lys Ser Gly Asp Ser Ser Ala Ser Ser Ser Ala Ser
465                 470                 475                 480
 
cca caa cct gaa ggg gac ggt act gat ttg cat aaa gtt tat caa gat   1488
Pro Gln Pro Glu Gly Asp Gly Thr Asp Leu His Lys Val Tyr Gln Asp
                485                 490                 495
 
ttg gtt aaa aag ttc ggt gat ttg ttt act gat ggt aaa aag caa act   1536
Leu Val Lys Lys Phe Gly Asp Leu Phe Thr Asp Gly Lys Lys Gln Thr
            500                 505                 510
 
ttc gag tct tta act gct aga cca aat aga tgt tat tat gtt gga gga   1584
Phe Glu Ser Leu Thr Ala Arg Pro Asn Arg Cys Tyr Tyr Val Gly Gly
        515                 520                 525
 
gct tct aat aat gga tct att att aaa atg gga tct att ttg gct cca   1632
Ala Ser Asn Asn Gly Ser Ile Ile Lys Met Gly Ser Ile Leu Ala Pro
    530                 535                 540
 
gtt aat gga aat tat aaa gtt gac att cca aac gct tgt gct ttg gga   1680
Val Asn Gly Asn Tyr Lys Val Asp Ile Pro Asn Ala Cys Ala Leu Gly
545                 550                 555                 560
 
ggt gct tat aag gct tct tgg tct tat gaa tgt gaa gct aaa aag gaa   1728
Gly Ala Tyr Lys Ala Ser Trp Ser Tyr Glu Cys Glu Ala Lys Lys Glu
                565                 570                 575
 
tgg ata ggg tat gat caa tat att aat aga ttg ttc gaa gtt tct gat   1776
Trp Ile Gly Tyr Asp Gln Tyr Ile Asn Arg Leu Phe Glu Val Ser Asp
            580                 585                 590
 
gaa atg aat ttg ttt gag gtt aaa gat aag tgg tta gaa tat gct aat   1824
Glu Met Asn Leu Phe Glu Val Lys Asp Lys Trp Leu Glu Tyr Ala Asn
        595                 600                 605
 
gga gtt gga atg cta gct aaa atg gaa agc gaa tta aaa cat           1866
Gly Val Gly Met Leu Ala Lys Met Glu Ser Glu Leu Lys His
    610                 615                 620
 


<210> 88
<211> 622
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in P. pastoris

<400> 88
Met Thr Thr Thr Pro Phe Asp Ala Pro Asp Lys Leu Phe Leu Gly Phe
 1               5                  10                  15      
Asp Leu Ser Thr Gln Gln Leu Lys Ile Ile Val Thr Asp Glu Asn Leu
            20                  25                  30          
Ala Ala Leu Lys Thr Tyr Asn Val Glu Phe Asp Ser Ile Asn Ser Ser
        35                  40                  45              
Val Gln Lys Gly Val Ile Ala Ile Asn Asp Glu Ile Ser Lys Gly Ala
    50                  55                  60                  
Ile Ile Ser Pro Val Tyr Met Trp Leu Asp Ala Leu Asp His Val Phe
65                  70                  75                  80  
Glu Asp Met Lys Lys Asp Gly Phe Pro Phe Asn Lys Val Val Gly Ile
                85                  90                  95      
Ser Gly Ser Cys Gln Gln His Gly Ser Val Tyr Trp Ser Arg Thr Ala
            100                 105                 110         
Glu Lys Val Leu Ser Glu Leu Asp Ala Glu Ser Ser Leu Ser Ser Gln
        115                 120                 125             
Met Arg Ser Ala Phe Thr Phe Lys His Ala Pro Asn Trp Gln Asp His
    130                 135                 140                 
Ser Thr Gly Lys Glu Leu Glu Glu Phe Glu Arg Val Ile Gly Ala Asp
145                 150                 155                 160 
Ala Leu Ala Asp Ile Ser Gly Ser Arg Ala His Tyr Arg Phe Thr Gly
                165                 170                 175     
Leu Gln Ile Arg Lys Leu Ser Thr Arg Phe Lys Pro Glu Lys Tyr Asn
            180                 185                 190         
Arg Thr Ala Arg Ile Ser Leu Val Ser Ser Phe Val Ala Ser Val Leu
        195                 200                 205             
Leu Gly Arg Ile Thr Ser Ile Glu Glu Ala Asp Ala Cys Gly Met Asn
    210                 215                 220                 
Leu Tyr Asp Ile Glu Lys Arg Glu Phe Asn Glu Glu Leu Leu Ala Ile
225                 230                 235                 240 
Ala Ala Gly Val His Pro Glu Leu Asp Gly Val Glu Gln Asp Gly Glu
                245                 250                 255     
Ile Tyr Arg Ala Gly Ile Asn Glu Leu Lys Arg Lys Leu Gly Pro Val
            260                 265                 270         
Lys Pro Ile Thr Tyr Glu Ser Glu Gly Asp Ile Ala Ser Tyr Phe Val
        275                 280                 285             
Thr Arg Tyr Gly Phe Asn Pro Asp Cys Lys Ile Tyr Ser Phe Thr Gly
    290                 295                 300                 
Asp Asn Leu Ala Thr Ile Ile Ser Leu Pro Leu Ala Pro Asn Asp Ala
305                 310                 315                 320 
Leu Ile Ser Leu Gly Thr Ser Thr Thr Val Leu Ile Ile Thr Lys Asn
                325                 330                 335     
Tyr Ala Pro Ser Ser Gln Tyr His Leu Phe Lys His Pro Thr Met Pro
            340                 345                 350         
Asp His Tyr Met Gly Met Ile Cys Tyr Cys Asn Gly Ser Leu Ala Arg
        355                 360                 365             
Glu Lys Val Arg Asp Glu Val Asn Glu Lys Phe Asn Val Glu Asp Lys
    370                 375                 380                 
Lys Ser Trp Asp Lys Phe Asn Glu Ile Leu Asp Lys Ser Thr Asp Phe
385                 390                 395                 400 
Asn Asn Lys Leu Gly Ile Tyr Phe Pro Leu Gly Glu Ile Val Pro Asn
                405                 410                 415     
Ala Ala Ala Gln Ile Lys Arg Ser Val Leu Asn Ser Lys Asn Glu Ile
            420                 425                 430         
Val Asp Val Glu Leu Gly Asp Lys Asn Trp Gln Pro Glu Asp Asp Val
        435                 440                 445             
Ser Ser Ile Val Glu Ser Gln Thr Leu Ser Cys Arg Leu Arg Thr Gly
    450                 455                 460                 
Pro Met Leu Ser Lys Ser Gly Asp Ser Ser Ala Ser Ser Ser Ala Ser
465                 470                 475                 480 
Pro Gln Pro Glu Gly Asp Gly Thr Asp Leu His Lys Val Tyr Gln Asp
                485                 490                 495     
Leu Val Lys Lys Phe Gly Asp Leu Phe Thr Asp Gly Lys Lys Gln Thr
            500                 505                 510         
Phe Glu Ser Leu Thr Ala Arg Pro Asn Arg Cys Tyr Tyr Val Gly Gly
        515                 520                 525             
Ala Ser Asn Asn Gly Ser Ile Ile Lys Met Gly Ser Ile Leu Ala Pro
    530                 535                 540                 
Val Asn Gly Asn Tyr Lys Val Asp Ile Pro Asn Ala Cys Ala Leu Gly
545                 550                 555                 560 
Gly Ala Tyr Lys Ala Ser Trp Ser Tyr Glu Cys Glu Ala Lys Lys Glu
                565                 570                 575     
Trp Ile Gly Tyr Asp Gln Tyr Ile Asn Arg Leu Phe Glu Val Ser Asp
            580                 585                 590         
Glu Met Asn Leu Phe Glu Val Lys Asp Lys Trp Leu Glu Tyr Ala Asn
        595                 600                 605             
Gly Val Gly Met Leu Ala Lys Met Glu Ser Glu Leu Lys His
    610                 615                 620         


<210> 89
<211> 1888
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in P. pastoris

<220> 
<221> CDS            
<222> (12)...(1878)

<400> 89
tactcaagct t atg act act act cca ttt gat gct cca gat aaa ttg ttt  50
             Met Thr Thr Thr Pro Phe Asp Ala Pro Asp Lys Leu Phe
              1               5                   10
 
ttg gga ttt gat ttg tct act caa caa tta aaa att att gtt act gat   98
Leu Gly Phe Asp Leu Ser Thr Gln Gln Leu Lys Ile Ile Val Thr Asp
     15                  20                  25
 
gaa aat ttg gct gct tta aaa act tat aat gtt gaa ttt gat tct att   146
Glu Asn Leu Ala Ala Leu Lys Thr Tyr Asn Val Glu Phe Asp Ser Ile
 30                  35                  40                  45
 
aat tct tct gtt caa aaa gga gtt att gct att aat gat gaa att tct   194
Asn Ser Ser Val Gln Lys Gly Val Ile Ala Ile Asn Asp Glu Ile Ser
                 50                  55                  60
 
aaa gga gct att att tct cca gtt tat atg tgg tta gac gct ttg gat   242
Lys Gly Ala Ile Ile Ser Pro Val Tyr Met Trp Leu Asp Ala Leu Asp
             65                  70                  75
 
cat gtt ttt gag gat atg aaa aag gac gga ttt cca ttt aat aaa gtt   290
His Val Phe Glu Asp Met Lys Lys Asp Gly Phe Pro Phe Asn Lys Val
         80                  85                  90
 
gtt gga att tct gga tct tgt cag caa cat gga tct gtt tat tgg tct   338
Val Gly Ile Ser Gly Ser Cys Gln Gln His Gly Ser Val Tyr Trp Ser
     95                 100                 105
 
aga act gct gaa aaa gtt ttg tct gaa ttg gat gct gaa tct tct tta   386
Arg Thr Ala Glu Lys Val Leu Ser Glu Leu Asp Ala Glu Ser Ser Leu
110                 115                 120                 125
 
tct tct caa atg aga tct gct ttt act ttt aaa cac gct cct aat tgg   434
Ser Ser Gln Met Arg Ser Ala Phe Thr Phe Lys His Ala Pro Asn Trp
                130                 135                 140
 
caa gat cat tct act gga aaa gaa tta gaa gaa ttt gag aga gtt att   482
Gln Asp His Ser Thr Gly Lys Glu Leu Glu Glu Phe Glu Arg Val Ile
            145                 150                 155
 
gga gct gat gct ttg gct gac att tct gga tct aga gca cat tat aga   530
Gly Ala Asp Ala Leu Ala Asp Ile Ser Gly Ser Arg Ala His Tyr Arg
        160                 165                 170
 
ttt act gga ttg caa att aga aaa ttg tct act aga ttt aaa cct gag   578
Phe Thr Gly Leu Gln Ile Arg Lys Leu Ser Thr Arg Phe Lys Pro Glu
    175                 180                 185
 
aaa tat aat aga act gct aga att tct tta gtt tct tct ttt gtt gct   626
Lys Tyr Asn Arg Thr Ala Arg Ile Ser Leu Val Ser Ser Phe Val Ala
190                 195                 200                 205
 
tct gtt ttg ttg gga agg att act tct att gag gag gct gat gct tgt   674
Ser Val Leu Leu Gly Arg Ile Thr Ser Ile Glu Glu Ala Asp Ala Cys
                210                 215                 220
 
gga atg aat ttg tat gac att gaa aaa cgt gaa ttt aat gaa gaa ttg   722
Gly Met Asn Leu Tyr Asp Ile Glu Lys Arg Glu Phe Asn Glu Glu Leu
            225                 230                 235
 
ttg gct att gct gcc ggt gtt cat cca gaa tta gat gga gtt gaa caa   770
Leu Ala Ile Ala Ala Gly Val His Pro Glu Leu Asp Gly Val Glu Gln
        240                 245                 250
 
gat ggg gaa att tat aga gct gga att aat gaa tta aaa aga aaa ttg   818
Asp Gly Glu Ile Tyr Arg Ala Gly Ile Asn Glu Leu Lys Arg Lys Leu
    255                 260                 265
 
gga cca gtt aaa cct att act tat gaa tct gaa gga gat ata gct tct   866
Gly Pro Val Lys Pro Ile Thr Tyr Glu Ser Glu Gly Asp Ile Ala Ser
270                 275                 280                 285
 
tat ttt gtt act aga tat ggt ttt aat cca gat tgt aaa att tat tct   914
Tyr Phe Val Thr Arg Tyr Gly Phe Asn Pro Asp Cys Lys Ile Tyr Ser
                290                 295                 300
 
ttt act gga gat aat ttg gct act att att tca ttg cct ttg gct cca   962
Phe Thr Gly Asp Asn Leu Ala Thr Ile Ile Ser Leu Pro Leu Ala Pro
            305                 310                 315
 
aat gat gct ttg att tca ttg gga aca tct act act gtt ttg att att   1010
Asn Asp Ala Leu Ile Ser Leu Gly Thr Ser Thr Thr Val Leu Ile Ile
        320                 325                 330
 
act aaa aat tat gct cca tct tct caa tat cat ttg ttt aag cat cca   1058
Thr Lys Asn Tyr Ala Pro Ser Ser Gln Tyr His Leu Phe Lys His Pro
    335                 340                 345
 
act atg cca gat cat tat atg gga atg att tgt tat tgt aat gga tct   1106
Thr Met Pro Asp His Tyr Met Gly Met Ile Cys Tyr Cys Asn Gly Ser
350                 355                 360                 365
 
tta gct aga gaa aaa gtt aga gat gaa gtt aat gaa aaa ttt aat gtt   1154
Leu Ala Arg Glu Lys Val Arg Asp Glu Val Asn Glu Lys Phe Asn Val
                370                 375                 380
 
gaa gat aaa aag tct tgg gat aaa ttt aat gaa att ttg gat aaa tca   1202
Glu Asp Lys Lys Ser Trp Asp Lys Phe Asn Glu Ile Leu Asp Lys Ser
            385                 390                 395
 
act gat ttt aat aat aag ttg gga att tat ttt cca ttg gga gaa att   1250
Thr Asp Phe Asn Asn Lys Leu Gly Ile Tyr Phe Pro Leu Gly Glu Ile
        400                 405                 410
 
gtt cca aat gca gca gct caa ata aag aga tct gtt tta aat tct aaa   1298
Val Pro Asn Ala Ala Ala Gln Ile Lys Arg Ser Val Leu Asn Ser Lys
    415                 420                 425
 
aat gaa att gtt gat gtt gaa tta gga gat aaa aat tgg caa cca gaa   1346
Asn Glu Ile Val Asp Val Glu Leu Gly Asp Lys Asn Trp Gln Pro Glu
430                 435                 440                 445
 
gat gat gtt tct agt att gtt gaa tct caa act tta tct tgt aga ttg   1394
Asp Asp Val Ser Ser Ile Val Glu Ser Gln Thr Leu Ser Cys Arg Leu
                450                 455                 460
 
aga act gga cca atg ttg tct aaa tct gga gat tct tct gca tct tct   1442
Arg Thr Gly Pro Met Leu Ser Lys Ser Gly Asp Ser Ser Ala Ser Ser
            465                 470                 475
 
agt gct agc cca caa cct gaa ggg gac ggt act gat ttg cat aaa gtt   1490
Ser Ala Ser Pro Gln Pro Glu Gly Asp Gly Thr Asp Leu His Lys Val
        480                 485                 490
 
tat caa gat ttg gtt aaa aag ttc ggt gat ttg ttt act gat ggt aaa   1538
Tyr Gln Asp Leu Val Lys Lys Phe Gly Asp Leu Phe Thr Asp Gly Lys
    495                 500                 505
 
aag caa act ttc gag tct tta act gct aga cca aat aga tgt tat tat   1586
Lys Gln Thr Phe Glu Ser Leu Thr Ala Arg Pro Asn Arg Cys Tyr Tyr
510                 515                 520                 525
 
gtt gga gga gct tct aat aat gga tct att att aaa atg gga tct att   1634
Val Gly Gly Ala Ser Asn Asn Gly Ser Ile Ile Lys Met Gly Ser Ile
                530                 535                 540
 
ttg gct cca gtt aat gga aat tat aaa gtt gac att cca aac gct tgt   1682
Leu Ala Pro Val Asn Gly Asn Tyr Lys Val Asp Ile Pro Asn Ala Cys
            545                 550                 555
 
gct ttg gga ggt gct tat aag gct tct tgg tct tat gaa tgt gaa gct   1730
Ala Leu Gly Gly Ala Tyr Lys Ala Ser Trp Ser Tyr Glu Cys Glu Ala
        560                 565                 570
 
aaa aag gaa tgg ata ggg tat gat caa tat att aat aga ttg ttc gaa   1778
Lys Lys Glu Trp Ile Gly Tyr Asp Gln Tyr Ile Asn Arg Leu Phe Glu
    575                 580                 585
 
gtt tct gat gaa atg aat ttg ttt gag gtt aaa gat aag tgg tta gaa   1826
Val Ser Asp Glu Met Asn Leu Phe Glu Val Lys Asp Lys Trp Leu Glu
590                 595                 600                 605
 
tat gct aat gga gtt gga atg cta gct aaa atg gaa agc gaa tta aaa   1874
Tyr Ala Asn Gly Val Gly Met Leu Ala Lys Met Glu Ser Glu Leu Lys
                610                 615                 620
 
cat g aattccgatg                                                  1888
His

 

<210> 90
<211> 622
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in P. pastoris

<400> 90
Met Thr Thr Thr Pro Phe Asp Ala Pro Asp Lys Leu Phe Leu Gly Phe
 1               5                  10                  15      
Asp Leu Ser Thr Gln Gln Leu Lys Ile Ile Val Thr Asp Glu Asn Leu
            20                  25                  30          
Ala Ala Leu Lys Thr Tyr Asn Val Glu Phe Asp Ser Ile Asn Ser Ser
        35                  40                  45              
Val Gln Lys Gly Val Ile Ala Ile Asn Asp Glu Ile Ser Lys Gly Ala
    50                  55                  60                  
Ile Ile Ser Pro Val Tyr Met Trp Leu Asp Ala Leu Asp His Val Phe
65                  70                  75                  80  
Glu Asp Met Lys Lys Asp Gly Phe Pro Phe Asn Lys Val Val Gly Ile
                85                  90                  95      
Ser Gly Ser Cys Gln Gln His Gly Ser Val Tyr Trp Ser Arg Thr Ala
            100                 105                 110         
Glu Lys Val Leu Ser Glu Leu Asp Ala Glu Ser Ser Leu Ser Ser Gln
        115                 120                 125             
Met Arg Ser Ala Phe Thr Phe Lys His Ala Pro Asn Trp Gln Asp His
    130                 135                 140                 
Ser Thr Gly Lys Glu Leu Glu Glu Phe Glu Arg Val Ile Gly Ala Asp
145                 150                 155                 160 
Ala Leu Ala Asp Ile Ser Gly Ser Arg Ala His Tyr Arg Phe Thr Gly
                165                 170                 175     
Leu Gln Ile Arg Lys Leu Ser Thr Arg Phe Lys Pro Glu Lys Tyr Asn
            180                 185                 190         
Arg Thr Ala Arg Ile Ser Leu Val Ser Ser Phe Val Ala Ser Val Leu
        195                 200                 205             
Leu Gly Arg Ile Thr Ser Ile Glu Glu Ala Asp Ala Cys Gly Met Asn
    210                 215                 220                 
Leu Tyr Asp Ile Glu Lys Arg Glu Phe Asn Glu Glu Leu Leu Ala Ile
225                 230                 235                 240 
Ala Ala Gly Val His Pro Glu Leu Asp Gly Val Glu Gln Asp Gly Glu
                245                 250                 255     
Ile Tyr Arg Ala Gly Ile Asn Glu Leu Lys Arg Lys Leu Gly Pro Val
            260                 265                 270         
Lys Pro Ile Thr Tyr Glu Ser Glu Gly Asp Ile Ala Ser Tyr Phe Val
        275                 280                 285             
Thr Arg Tyr Gly Phe Asn Pro Asp Cys Lys Ile Tyr Ser Phe Thr Gly
    290                 295                 300                 
Asp Asn Leu Ala Thr Ile Ile Ser Leu Pro Leu Ala Pro Asn Asp Ala
305                 310                 315                 320 
Leu Ile Ser Leu Gly Thr Ser Thr Thr Val Leu Ile Ile Thr Lys Asn
                325                 330                 335     
Tyr Ala Pro Ser Ser Gln Tyr His Leu Phe Lys His Pro Thr Met Pro
            340                 345                 350         
Asp His Tyr Met Gly Met Ile Cys Tyr Cys Asn Gly Ser Leu Ala Arg
        355                 360                 365             
Glu Lys Val Arg Asp Glu Val Asn Glu Lys Phe Asn Val Glu Asp Lys
    370                 375                 380                 
Lys Ser Trp Asp Lys Phe Asn Glu Ile Leu Asp Lys Ser Thr Asp Phe
385                 390                 395                 400 
Asn Asn Lys Leu Gly Ile Tyr Phe Pro Leu Gly Glu Ile Val Pro Asn
                405                 410                 415     
Ala Ala Ala Gln Ile Lys Arg Ser Val Leu Asn Ser Lys Asn Glu Ile
            420                 425                 430         
Val Asp Val Glu Leu Gly Asp Lys Asn Trp Gln Pro Glu Asp Asp Val
        435                 440                 445             
Ser Ser Ile Val Glu Ser Gln Thr Leu Ser Cys Arg Leu Arg Thr Gly
    450                 455                 460                 
Pro Met Leu Ser Lys Ser Gly Asp Ser Ser Ala Ser Ser Ser Ala Ser
465                 470                 475                 480 
Pro Gln Pro Glu Gly Asp Gly Thr Asp Leu His Lys Val Tyr Gln Asp
                485                 490                 495     
Leu Val Lys Lys Phe Gly Asp Leu Phe Thr Asp Gly Lys Lys Gln Thr
            500                 505                 510         
Phe Glu Ser Leu Thr Ala Arg Pro Asn Arg Cys Tyr Tyr Val Gly Gly
        515                 520                 525             
Ala Ser Asn Asn Gly Ser Ile Ile Lys Met Gly Ser Ile Leu Ala Pro
    530                 535                 540                 
Val Asn Gly Asn Tyr Lys Val Asp Ile Pro Asn Ala Cys Ala Leu Gly
545                 550                 555                 560 
Gly Ala Tyr Lys Ala Ser Trp Ser Tyr Glu Cys Glu Ala Lys Lys Glu
                565                 570                 575     
Trp Ile Gly Tyr Asp Gln Tyr Ile Asn Arg Leu Phe Glu Val Ser Asp
            580                 585                 590         
Glu Met Asn Leu Phe Glu Val Lys Asp Lys Trp Leu Glu Tyr Ala Asn
        595                 600                 605             
Gly Val Gly Met Leu Ala Lys Met Glu Ser Glu Leu Lys His
    610                 615                 620         


<210> 91
<211> 1894
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in P. pastoris

<220> 
<221> CDS            
<222> (15)...(1880)

<400> 91
gaatactcca tatg atg act act act cca ttt gat gct cca gat aaa ttg   50
                Met Thr Thr Thr Pro Phe Asp Ala Pro Asp Lys Leu
                 1               5                   10
 
ttt ttg gga ttt gat ttg tct act caa caa tta aaa att att gtt act   98
Phe Leu Gly Phe Asp Leu Ser Thr Gln Gln Leu Lys Ile Ile Val Thr
         15                  20                  25
 
gat gaa aat ttg gct gct tta aaa act tat aat gtt gaa ttt gat tct   146
Asp Glu Asn Leu Ala Ala Leu Lys Thr Tyr Asn Val Glu Phe Asp Ser
     30                  35                  40
 
att aat tct tct gtt caa aaa gga gtt att gct att aat gat gaa att   194
Ile Asn Ser Ser Val Gln Lys Gly Val Ile Ala Ile Asn Asp Glu Ile
 45                  50                  55                  60
 
tct aaa gga gct att att tct cca gtt tat atg tgg tta gac gct ttg   242
Ser Lys Gly Ala Ile Ile Ser Pro Val Tyr Met Trp Leu Asp Ala Leu
                 65                  70                  75
 
gat cat gtt ttt gag gat atg aaa aag gac gga ttt cca ttt aat aaa   290
Asp His Val Phe Glu Asp Met Lys Lys Asp Gly Phe Pro Phe Asn Lys
             80                  85                  90
 
gtt gtt gga att tct gga tct tgt cag caa cat gga tct gtt tat tgg   338
Val Val Gly Ile Ser Gly Ser Cys Gln Gln His Gly Ser Val Tyr Trp
         95                 100                 105
 
tct aga act gct gaa aaa gtt ttg tct gaa ttg gat gct gaa tct tct   386
Ser Arg Thr Ala Glu Lys Val Leu Ser Glu Leu Asp Ala Glu Ser Ser
    110                 115                 120
 
tta tct tct caa atg aga tct gct ttt act ttt aaa cac gct cct aat   434
Leu Ser Ser Gln Met Arg Ser Ala Phe Thr Phe Lys His Ala Pro Asn
125                 130                 135                 140
 
tgg caa gat cat tct act gga aaa gaa tta gaa gaa ttt gag aga gtt   482
Trp Gln Asp His Ser Thr Gly Lys Glu Leu Glu Glu Phe Glu Arg Val
                145                 150                 155
 
att gga gct gat gct ttg gct gac att tct gga tct aga gca cat tat   530
Ile Gly Ala Asp Ala Leu Ala Asp Ile Ser Gly Ser Arg Ala His Tyr
            160                 165                 170
 
aga ttt act gga ttg caa att aga aaa ttg tct act aga ttt aaa cct   578
Arg Phe Thr Gly Leu Gln Ile Arg Lys Leu Ser Thr Arg Phe Lys Pro
        175                 180                 185
 
gag aaa tat aat aga act gct aga att tct tta gtt tct tct ttt gtt   626
Glu Lys Tyr Asn Arg Thr Ala Arg Ile Ser Leu Val Ser Ser Phe Val
    190                 195                 200
 
gct tct gtt ttg ttg gga agg att act tct att gag gag gct gat gct   674
Ala Ser Val Leu Leu Gly Arg Ile Thr Ser Ile Glu Glu Ala Asp Ala
205                 210                 215                 220
 
tgt gga atg aat ttg tat gac att gaa aaa cgt gaa ttt aat gaa gaa   722
Cys Gly Met Asn Leu Tyr Asp Ile Glu Lys Arg Glu Phe Asn Glu Glu
                225                 230                 235
 
ttg ttg gct att gct gcc ggt gtt cat cca gaa tta gat gga gtt gaa   770
Leu Leu Ala Ile Ala Ala Gly Val His Pro Glu Leu Asp Gly Val Glu
            240                 245                 250
 
caa gat ggg gaa att tat aga gct gga att aat gaa tta aaa aga aaa   818
Gln Asp Gly Glu Ile Tyr Arg Ala Gly Ile Asn Glu Leu Lys Arg Lys
        255                 260                 265
 
ttg gga cca gtt aaa cct att act tat gaa tct gaa gga gat ata gct   866
Leu Gly Pro Val Lys Pro Ile Thr Tyr Glu Ser Glu Gly Asp Ile Ala
    270                 275                 280
 
tct tat ttt gtt act aga tat ggt ttt aat cca gat tgt aaa att tat   914
Ser Tyr Phe Val Thr Arg Tyr Gly Phe Asn Pro Asp Cys Lys Ile Tyr
285                 290                 295                 300
 
tct ttt act gga gat aat ttg gct act att att tca ttg cct ttg gct   962
Ser Phe Thr Gly Asp Asn Leu Ala Thr Ile Ile Ser Leu Pro Leu Ala
                305                 310                 315
 
cca aat gat gct ttg att tca ttg gga aca tct act act gtt ttg att   1010
Pro Asn Asp Ala Leu Ile Ser Leu Gly Thr Ser Thr Thr Val Leu Ile
            320                 325                 330
 
att act aaa aat tat gct cca tct tct caa tat cat ttg ttt aag cat   1058
Ile Thr Lys Asn Tyr Ala Pro Ser Ser Gln Tyr His Leu Phe Lys His
        335                 340                 345
 
cca act atg cca gat cat tat atg gga atg att tgt tat tgt aat gga   1106
Pro Thr Met Pro Asp His Tyr Met Gly Met Ile Cys Tyr Cys Asn Gly
    350                 355                 360
 
tct tta gct aga gaa aaa gtt aga gat gaa gtt aat gaa aaa ttt aat   1154
Ser Leu Ala Arg Glu Lys Val Arg Asp Glu Val Asn Glu Lys Phe Asn
365                 370                 375                 380
 
gtt gaa gat aaa aag tct tgg gat aaa ttt aat gaa att ttg gat aaa   1202
Val Glu Asp Lys Lys Ser Trp Asp Lys Phe Asn Glu Ile Leu Asp Lys
                385                 390                 395
 
tca act gat ttt aat aat aag ttg gga att tat ttt cca ttg gga gaa   1250
Ser Thr Asp Phe Asn Asn Lys Leu Gly Ile Tyr Phe Pro Leu Gly Glu
            400                 405                 410
 
att gtt cca aat gca gca gct caa ata aag aga tct gtt tta aat tct   1298
Ile Val Pro Asn Ala Ala Ala Gln Ile Lys Arg Ser Val Leu Asn Ser
        415                 420                 425
 
aaa aat gaa att gtt gat gtt gaa tta gga gat aaa aat tgg caa cca   1346
Lys Asn Glu Ile Val Asp Val Glu Leu Gly Asp Lys Asn Trp Gln Pro
    430                 435                 440
 
gaa gat gat gtt tct agt att gtt gaa tct caa act tta tct tgt aga   1394
Glu Asp Asp Val Ser Ser Ile Val Glu Ser Gln Thr Leu Ser Cys Arg
445                 450                 455                 460
 
ttg aga act gga cca atg ttg tct aaa tct gga gat tct tct gca tct   1442
Leu Arg Thr Gly Pro Met Leu Ser Lys Ser Gly Asp Ser Ser Ala Ser
                465                 470                 475
 
tct agt gct agc cca caa cct gaa ggg gac ggt act gat ttg cat aaa   1490
Ser Ser Ala Ser Pro Gln Pro Glu Gly Asp Gly Thr Asp Leu His Lys
            480                 485                 490
 
gtt tat caa gat ttg gtt aaa aag ttc ggt gat ttg ttt act gat ggt   1538
Val Tyr Gln Asp Leu Val Lys Lys Phe Gly Asp Leu Phe Thr Asp Gly
        495                 500                 505
 
aaa aag caa act ttc gag tct tta act gct aga cca aat aga tgt tat   1586
Lys Lys Gln Thr Phe Glu Ser Leu Thr Ala Arg Pro Asn Arg Cys Tyr
    510                 515                 520
 
tat gtt gga gga gct tct aat aat gga tct att att aaa atg gga tct   1634
Tyr Val Gly Gly Ala Ser Asn Asn Gly Ser Ile Ile Lys Met Gly Ser
525                 530                 535                 540
 
att ttg gct cca gtt aat gga aat tat aaa gtt gac att cca aac gct   1682
Ile Leu Ala Pro Val Asn Gly Asn Tyr Lys Val Asp Ile Pro Asn Ala
                545                 550                 555
 
tgt gct ttg gga ggt gct tat aag gct tct tgg tct tat gaa tgt gaa   1730
Cys Ala Leu Gly Gly Ala Tyr Lys Ala Ser Trp Ser Tyr Glu Cys Glu
            560                 565                 570
 
gct aaa aag gaa tgg ata ggg tat gat caa tat att aat aga ttg ttc   1778
Ala Lys Lys Glu Trp Ile Gly Tyr Asp Gln Tyr Ile Asn Arg Leu Phe
        575                 580                 585
 
gaa gtt tct gat gaa atg aat ttg ttt gag gtt aaa gat aag tgg tta   1826
Glu Val Ser Asp Glu Met Asn Leu Phe Glu Val Lys Asp Lys Trp Leu
    590                 595                 600
 
gaa tat gct aat gga gtt gga atg cta gct aaa atg gaa agc gaa tta   1874
Glu Tyr Ala Asn Gly Val Gly Met Leu Ala Lys Met Glu Ser Glu Leu
605                 610                 615                 620
 
aaa cat actagtcgat gcct                                           1894
Lys His

 

<210> 92
<211> 622
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in P. pastoris

<400> 92
Met Thr Thr Thr Pro Phe Asp Ala Pro Asp Lys Leu Phe Leu Gly Phe
 1               5                  10                  15      
Asp Leu Ser Thr Gln Gln Leu Lys Ile Ile Val Thr Asp Glu Asn Leu
            20                  25                  30          
Ala Ala Leu Lys Thr Tyr Asn Val Glu Phe Asp Ser Ile Asn Ser Ser
        35                  40                  45              
Val Gln Lys Gly Val Ile Ala Ile Asn Asp Glu Ile Ser Lys Gly Ala
    50                  55                  60                  
Ile Ile Ser Pro Val Tyr Met Trp Leu Asp Ala Leu Asp His Val Phe
65                  70                  75                  80  
Glu Asp Met Lys Lys Asp Gly Phe Pro Phe Asn Lys Val Val Gly Ile
                85                  90                  95      
Ser Gly Ser Cys Gln Gln His Gly Ser Val Tyr Trp Ser Arg Thr Ala
            100                 105                 110         
Glu Lys Val Leu Ser Glu Leu Asp Ala Glu Ser Ser Leu Ser Ser Gln
        115                 120                 125             
Met Arg Ser Ala Phe Thr Phe Lys His Ala Pro Asn Trp Gln Asp His
    130                 135                 140                 
Ser Thr Gly Lys Glu Leu Glu Glu Phe Glu Arg Val Ile Gly Ala Asp
145                 150                 155                 160 
Ala Leu Ala Asp Ile Ser Gly Ser Arg Ala His Tyr Arg Phe Thr Gly
                165                 170                 175     
Leu Gln Ile Arg Lys Leu Ser Thr Arg Phe Lys Pro Glu Lys Tyr Asn
            180                 185                 190         
Arg Thr Ala Arg Ile Ser Leu Val Ser Ser Phe Val Ala Ser Val Leu
        195                 200                 205             
Leu Gly Arg Ile Thr Ser Ile Glu Glu Ala Asp Ala Cys Gly Met Asn
    210                 215                 220                 
Leu Tyr Asp Ile Glu Lys Arg Glu Phe Asn Glu Glu Leu Leu Ala Ile
225                 230                 235                 240 
Ala Ala Gly Val His Pro Glu Leu Asp Gly Val Glu Gln Asp Gly Glu
                245                 250                 255     
Ile Tyr Arg Ala Gly Ile Asn Glu Leu Lys Arg Lys Leu Gly Pro Val
            260                 265                 270         
Lys Pro Ile Thr Tyr Glu Ser Glu Gly Asp Ile Ala Ser Tyr Phe Val
        275                 280                 285             
Thr Arg Tyr Gly Phe Asn Pro Asp Cys Lys Ile Tyr Ser Phe Thr Gly
    290                 295                 300                 
Asp Asn Leu Ala Thr Ile Ile Ser Leu Pro Leu Ala Pro Asn Asp Ala
305                 310                 315                 320 
Leu Ile Ser Leu Gly Thr Ser Thr Thr Val Leu Ile Ile Thr Lys Asn
                325                 330                 335     
Tyr Ala Pro Ser Ser Gln Tyr His Leu Phe Lys His Pro Thr Met Pro
            340                 345                 350         
Asp His Tyr Met Gly Met Ile Cys Tyr Cys Asn Gly Ser Leu Ala Arg
        355                 360                 365             
Glu Lys Val Arg Asp Glu Val Asn Glu Lys Phe Asn Val Glu Asp Lys
    370                 375                 380                 
Lys Ser Trp Asp Lys Phe Asn Glu Ile Leu Asp Lys Ser Thr Asp Phe
385                 390                 395                 400 
Asn Asn Lys Leu Gly Ile Tyr Phe Pro Leu Gly Glu Ile Val Pro Asn
                405                 410                 415     
Ala Ala Ala Gln Ile Lys Arg Ser Val Leu Asn Ser Lys Asn Glu Ile
            420                 425                 430         
Val Asp Val Glu Leu Gly Asp Lys Asn Trp Gln Pro Glu Asp Asp Val
        435                 440                 445             
Ser Ser Ile Val Glu Ser Gln Thr Leu Ser Cys Arg Leu Arg Thr Gly
    450                 455                 460                 
Pro Met Leu Ser Lys Ser Gly Asp Ser Ser Ala Ser Ser Ser Ala Ser
465                 470                 475                 480 
Pro Gln Pro Glu Gly Asp Gly Thr Asp Leu His Lys Val Tyr Gln Asp
                485                 490                 495     
Leu Val Lys Lys Phe Gly Asp Leu Phe Thr Asp Gly Lys Lys Gln Thr
            500                 505                 510         
Phe Glu Ser Leu Thr Ala Arg Pro Asn Arg Cys Tyr Tyr Val Gly Gly
        515                 520                 525             
Ala Ser Asn Asn Gly Ser Ile Ile Lys Met Gly Ser Ile Leu Ala Pro
    530                 535                 540                 
Val Asn Gly Asn Tyr Lys Val Asp Ile Pro Asn Ala Cys Ala Leu Gly
545                 550                 555                 560 
Gly Ala Tyr Lys Ala Ser Trp Ser Tyr Glu Cys Glu Ala Lys Lys Glu
                565                 570                 575     
Trp Ile Gly Tyr Asp Gln Tyr Ile Asn Arg Leu Phe Glu Val Ser Asp
            580                 585                 590         
Glu Met Asn Leu Phe Glu Val Lys Asp Lys Trp Leu Glu Tyr Ala Asn
        595                 600                 605             
Gly Val Gly Met Leu Ala Lys Met Glu Ser Glu Leu Lys His
    610                 615                 620         


<210> 93
<211> 1866
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in K. lactis

<220> 
<221> CDS            
<222> (1)...(1866)

<400> 93
atg act act act cca ttc gat gct cca gat aag ttg ttc ttg ggt ttc   48
Met Thr Thr Thr Pro Phe Asp Ala Pro Asp Lys Leu Phe Leu Gly Phe
 1               5                   10                  15
 
gat ttg tct act caa caa tta aag att att gtt act gat gaa aat ttg   96
Asp Leu Ser Thr Gln Gln Leu Lys Ile Ile Val Thr Asp Glu Asn Leu
             20                  25                  30
 
gct gct tta aaa act tat aat gtt gaa ttt gat tct att aat tct tct   144
Ala Ala Leu Lys Thr Tyr Asn Val Glu Phe Asp Ser Ile Asn Ser Ser
         35                  40                  45
 
gtt caa aaa ggt gtt att gct att aat gat gaa att tct aaa ggt gct   192
Val Gln Lys Gly Val Ile Ala Ile Asn Asp Glu Ile Ser Lys Gly Ala
     50                  55                  60
 
att att tct cct gtt tat atg tgg ttg gat gcc tta gat cat gtt ttc   240
Ile Ile Ser Pro Val Tyr Met Trp Leu Asp Ala Leu Asp His Val Phe
 65                  70                  75                  80
 
gaa gat atg aaa aag gat ggt ttt ccg ttc aat aaa gtt gtt ggt ata   288
Glu Asp Met Lys Lys Asp Gly Phe Pro Phe Asn Lys Val Val Gly Ile
                 85                  90                  95
 
tct ggt tca tgt caa caa cat ggt tct gtt tat tgg tct agg act gct   336
Ser Gly Ser Cys Gln Gln His Gly Ser Val Tyr Trp Ser Arg Thr Ala
            100                 105                 110
 
gaa aaa gtt ttg tcc gaa ttg gac gca gaa tct tct tta tct tct caa   384
Glu Lys Val Leu Ser Glu Leu Asp Ala Glu Ser Ser Leu Ser Ser Gln
        115                 120                 125
 
atg aga tct gct ttc act ttc aaa cat gcg cct aat tgg caa gat cat   432
Met Arg Ser Ala Phe Thr Phe Lys His Ala Pro Asn Trp Gln Asp His
    130                 135                 140
 
tct act gga aaa gaa ttg gaa gaa ttt gaa aga gtt att ggt gct gat   480
Ser Thr Gly Lys Glu Leu Glu Glu Phe Glu Arg Val Ile Gly Ala Asp
145                 150                 155                 160
 
gct tta gct gac att tct ggt agt agg gct cat tat aga ttc act ggt   528
Ala Leu Ala Asp Ile Ser Gly Ser Arg Ala His Tyr Arg Phe Thr Gly
                165                 170                 175
 
ctt caa att aga aaa ttg tct acc agg ttc aaa ccg gaa aaa tat aat   576
Leu Gln Ile Arg Lys Leu Ser Thr Arg Phe Lys Pro Glu Lys Tyr Asn
            180                 185                 190
 
aga act gct aga att tct tta gtt tct tct ttc gtt gct tct gta tta   624
Arg Thr Ala Arg Ile Ser Leu Val Ser Ser Phe Val Ala Ser Val Leu
        195                 200                 205
 
tta ggt aga att aca agt att gaa gaa gca gac gcc tgt ggt atg aat   672
Leu Gly Arg Ile Thr Ser Ile Glu Glu Ala Asp Ala Cys Gly Met Asn
    210                 215                 220
 
ttg tat gac att gaa aag aga gag ttc aat gaa gaa ttg ctc gct att   720
Leu Tyr Asp Ile Glu Lys Arg Glu Phe Asn Glu Glu Leu Leu Ala Ile
225                 230                 235                 240
 
gct gca ggt gtt cat cca gaa tta gac gga gtt gaa caa gat ggt gaa   768
Ala Ala Gly Val His Pro Glu Leu Asp Gly Val Glu Gln Asp Gly Glu
                245                 250                 255
 
att tat aga gct ggt ata aat gaa tta aag aga aaa ttg ggt cca gtt   816
Ile Tyr Arg Ala Gly Ile Asn Glu Leu Lys Arg Lys Leu Gly Pro Val
            260                 265                 270
 
aaa cca att act tat gaa tct gaa ggt gat ata gct tct tac ttc gtt   864
Lys Pro Ile Thr Tyr Glu Ser Glu Gly Asp Ile Ala Ser Tyr Phe Val
        275                 280                 285
 
act aga tat ggt ttc aat cca gat tgt aaa att tat tct ttc acg gga   912
Thr Arg Tyr Gly Phe Asn Pro Asp Cys Lys Ile Tyr Ser Phe Thr Gly
    290                 295                 300
 
gat aat tta gcc act att att tca ttg cca tta gct cca aat gac gct   960
Asp Asn Leu Ala Thr Ile Ile Ser Leu Pro Leu Ala Pro Asn Asp Ala
305                 310                 315                 320
 
ttg att tca ttg gga act tct act act gtt ctg att att act aaa aat   1008
Leu Ile Ser Leu Gly Thr Ser Thr Thr Val Leu Ile Ile Thr Lys Asn
                325                 330                 335
 
tat gca cct agt agt caa tat cat ttg ttc aaa cat cct act atg cca   1056
Tyr Ala Pro Ser Ser Gln Tyr His Leu Phe Lys His Pro Thr Met Pro
            340                 345                 350
 
gat cat tat atg ggt atg atc tgt tat tgt aat ggt tct tta gct aga   1104
Asp His Tyr Met Gly Met Ile Cys Tyr Cys Asn Gly Ser Leu Ala Arg
        355                 360                 365
 
gaa aaa gtt aga gat gaa gtt aat gaa aaa ttc aat gtt gaa gac aaa   1152
Glu Lys Val Arg Asp Glu Val Asn Glu Lys Phe Asn Val Glu Asp Lys
    370                 375                 380
 
aag tca tgg gac aaa ttt aac gag att ttg gat aag tct act gat ttc   1200
Lys Ser Trp Asp Lys Phe Asn Glu Ile Leu Asp Lys Ser Thr Asp Phe
385                 390                 395                 400
 
aat aat aaa tta gga att tat ttt cca ttg ggt gaa ata gtt cca aat   1248
Asn Asn Lys Leu Gly Ile Tyr Phe Pro Leu Gly Glu Ile Val Pro Asn
                405                 410                 415
 
gca gcg gct caa att aaa aga tct gtt tta aat tct aaa aat gaa att   1296
Ala Ala Ala Gln Ile Lys Arg Ser Val Leu Asn Ser Lys Asn Glu Ile
            420                 425                 430
 
gtt gat gtt gaa ctc gga gac aag aac tgg caa cca gaa gat gat gtt   1344
Val Asp Val Glu Leu Gly Asp Lys Asn Trp Gln Pro Glu Asp Asp Val
        435                 440                 445
 
tct tcc att gta gag tca caa aca ttg tct tgt aga ttg aga aca ggt   1392
Ser Ser Ile Val Glu Ser Gln Thr Leu Ser Cys Arg Leu Arg Thr Gly
    450                 455                 460
 
cca atg ttg tct aaa tct ggt gat tct tca gct tct agt tct gca tcg   1440
Pro Met Leu Ser Lys Ser Gly Asp Ser Ser Ala Ser Ser Ser Ala Ser
465                 470                 475                 480
 
cca caa cct gag gga gac gga aca gat ttg cat aaa gtt tat caa gat   1488
Pro Gln Pro Glu Gly Asp Gly Thr Asp Leu His Lys Val Tyr Gln Asp
                485                 490                 495
 
ttg gtt aaa aag ttc ggt gat ttg ttc act gat ggc aaa aag caa act   1536
Leu Val Lys Lys Phe Gly Asp Leu Phe Thr Asp Gly Lys Lys Gln Thr
            500                 505                 510
 
ttc gaa tct tta act gcc aga cct aac aga tgt tat tat gtt ggt ggt   1584
Phe Glu Ser Leu Thr Ala Arg Pro Asn Arg Cys Tyr Tyr Val Gly Gly
        515                 520                 525
 
gcg tct aac aat ggt tca att att aaa atg ggt tct att ttg gcc ccg   1632
Ala Ser Asn Asn Gly Ser Ile Ile Lys Met Gly Ser Ile Leu Ala Pro
    530                 535                 540
 
gtg aat ggt aat tat aaa gtt gac att cca aac gct tgt gct ttg ggt   1680
Val Asn Gly Asn Tyr Lys Val Asp Ile Pro Asn Ala Cys Ala Leu Gly
545                 550                 555                 560
 
gga gcc tat aaa gca agt tgg tct tat gaa tgt gag gct aaa aag gaa   1728
Gly Ala Tyr Lys Ala Ser Trp Ser Tyr Glu Cys Glu Ala Lys Lys Glu
                565                 570                 575
 
tgg att ggt tat gat caa tat att aat aga ttg ttc gaa gtg tct gat   1776
Trp Ile Gly Tyr Asp Gln Tyr Ile Asn Arg Leu Phe Glu Val Ser Asp
            580                 585                 590
 
gag atg aat tta ttc gag gtt aaa gat aag tgg tta gaa tat gct aac   1824
Glu Met Asn Leu Phe Glu Val Lys Asp Lys Trp Leu Glu Tyr Ala Asn
        595                 600                 605
 
ggt gtg gga atg ttg gcg aaa atg gag agt gaa tta aaa cat           1866
Gly Val Gly Met Leu Ala Lys Met Glu Ser Glu Leu Lys His
    610                 615                 620
 


<210> 94
<211> 622
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in K. lactis

<400> 94
Met Thr Thr Thr Pro Phe Asp Ala Pro Asp Lys Leu Phe Leu Gly Phe
 1               5                  10                  15      
Asp Leu Ser Thr Gln Gln Leu Lys Ile Ile Val Thr Asp Glu Asn Leu
            20                  25                  30          
Ala Ala Leu Lys Thr Tyr Asn Val Glu Phe Asp Ser Ile Asn Ser Ser
        35                  40                  45              
Val Gln Lys Gly Val Ile Ala Ile Asn Asp Glu Ile Ser Lys Gly Ala
    50                  55                  60                  
Ile Ile Ser Pro Val Tyr Met Trp Leu Asp Ala Leu Asp His Val Phe
65                  70                  75                  80  
Glu Asp Met Lys Lys Asp Gly Phe Pro Phe Asn Lys Val Val Gly Ile
                85                  90                  95      
Ser Gly Ser Cys Gln Gln His Gly Ser Val Tyr Trp Ser Arg Thr Ala
            100                 105                 110         
Glu Lys Val Leu Ser Glu Leu Asp Ala Glu Ser Ser Leu Ser Ser Gln
        115                 120                 125             
Met Arg Ser Ala Phe Thr Phe Lys His Ala Pro Asn Trp Gln Asp His
    130                 135                 140                 
Ser Thr Gly Lys Glu Leu Glu Glu Phe Glu Arg Val Ile Gly Ala Asp
145                 150                 155                 160 
Ala Leu Ala Asp Ile Ser Gly Ser Arg Ala His Tyr Arg Phe Thr Gly
                165                 170                 175     
Leu Gln Ile Arg Lys Leu Ser Thr Arg Phe Lys Pro Glu Lys Tyr Asn
            180                 185                 190         
Arg Thr Ala Arg Ile Ser Leu Val Ser Ser Phe Val Ala Ser Val Leu
        195                 200                 205             
Leu Gly Arg Ile Thr Ser Ile Glu Glu Ala Asp Ala Cys Gly Met Asn
    210                 215                 220                 
Leu Tyr Asp Ile Glu Lys Arg Glu Phe Asn Glu Glu Leu Leu Ala Ile
225                 230                 235                 240 
Ala Ala Gly Val His Pro Glu Leu Asp Gly Val Glu Gln Asp Gly Glu
                245                 250                 255     
Ile Tyr Arg Ala Gly Ile Asn Glu Leu Lys Arg Lys Leu Gly Pro Val
            260                 265                 270         
Lys Pro Ile Thr Tyr Glu Ser Glu Gly Asp Ile Ala Ser Tyr Phe Val
        275                 280                 285             
Thr Arg Tyr Gly Phe Asn Pro Asp Cys Lys Ile Tyr Ser Phe Thr Gly
    290                 295                 300                 
Asp Asn Leu Ala Thr Ile Ile Ser Leu Pro Leu Ala Pro Asn Asp Ala
305                 310                 315                 320 
Leu Ile Ser Leu Gly Thr Ser Thr Thr Val Leu Ile Ile Thr Lys Asn
                325                 330                 335     
Tyr Ala Pro Ser Ser Gln Tyr His Leu Phe Lys His Pro Thr Met Pro
            340                 345                 350         
Asp His Tyr Met Gly Met Ile Cys Tyr Cys Asn Gly Ser Leu Ala Arg
        355                 360                 365             
Glu Lys Val Arg Asp Glu Val Asn Glu Lys Phe Asn Val Glu Asp Lys
    370                 375                 380                 
Lys Ser Trp Asp Lys Phe Asn Glu Ile Leu Asp Lys Ser Thr Asp Phe
385                 390                 395                 400 
Asn Asn Lys Leu Gly Ile Tyr Phe Pro Leu Gly Glu Ile Val Pro Asn
                405                 410                 415     
Ala Ala Ala Gln Ile Lys Arg Ser Val Leu Asn Ser Lys Asn Glu Ile
            420                 425                 430         
Val Asp Val Glu Leu Gly Asp Lys Asn Trp Gln Pro Glu Asp Asp Val
        435                 440                 445             
Ser Ser Ile Val Glu Ser Gln Thr Leu Ser Cys Arg Leu Arg Thr Gly
    450                 455                 460                 
Pro Met Leu Ser Lys Ser Gly Asp Ser Ser Ala Ser Ser Ser Ala Ser
465                 470                 475                 480 
Pro Gln Pro Glu Gly Asp Gly Thr Asp Leu His Lys Val Tyr Gln Asp
                485                 490                 495     
Leu Val Lys Lys Phe Gly Asp Leu Phe Thr Asp Gly Lys Lys Gln Thr
            500                 505                 510         
Phe Glu Ser Leu Thr Ala Arg Pro Asn Arg Cys Tyr Tyr Val Gly Gly
        515                 520                 525             
Ala Ser Asn Asn Gly Ser Ile Ile Lys Met Gly Ser Ile Leu Ala Pro
    530                 535                 540                 
Val Asn Gly Asn Tyr Lys Val Asp Ile Pro Asn Ala Cys Ala Leu Gly
545                 550                 555                 560 
Gly Ala Tyr Lys Ala Ser Trp Ser Tyr Glu Cys Glu Ala Lys Lys Glu
                565                 570                 575     
Trp Ile Gly Tyr Asp Gln Tyr Ile Asn Arg Leu Phe Glu Val Ser Asp
            580                 585                 590         
Glu Met Asn Leu Phe Glu Val Lys Asp Lys Trp Leu Glu Tyr Ala Asn
        595                 600                 605             
Gly Val Gly Met Leu Ala Lys Met Glu Ser Glu Leu Lys His
    610                 615                 620         


<210> 95
<211> 1866
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in Z. mobilis

<220> 
<221> CDS            
<222> (1)...(1866)

<400> 95
atg acc acc acc ccg ttt gac gcc ccg gat aaa ttg ttt ttg ggt ttt   48
Met Thr Thr Thr Pro Phe Asp Ala Pro Asp Lys Leu Phe Leu Gly Phe
 1               5                   10                  15
 
gat ttg tct acc cag cag ttg aaa att att gtt acc gat gaa aat tta   96
Asp Leu Ser Thr Gln Gln Leu Lys Ile Ile Val Thr Asp Glu Asn Leu
             20                  25                  30
 
gcc gcc tta aaa acg tat aat gtt gaa ttt gat tct att aat tct tct   144
Ala Ala Leu Lys Thr Tyr Asn Val Glu Phe Asp Ser Ile Asn Ser Ser
         35                  40                  45
 
gtt cag aaa ggt gtc att gcc att aat gat gaa att tct aaa ggt gcc   192
Val Gln Lys Gly Val Ile Ala Ile Asn Asp Glu Ile Ser Lys Gly Ala
     50                  55                  60
 
atc att tct ccg gtt tat atg tgg ttg gac gcg ctt gac cat gtt ttt   240
Ile Ile Ser Pro Val Tyr Met Trp Leu Asp Ala Leu Asp His Val Phe
 65                  70                  75                  80
 
gaa gat atg aag aaa gat ggt ttt ccg ttt aat aaa gtt gtt ggc att   288
Glu Asp Met Lys Lys Asp Gly Phe Pro Phe Asn Lys Val Val Gly Ile
                 85                  90                  95
 
agc ggt tct tgt caa cag cat ggt tct gtt tat tgg tct cgt acc gcc   336
Ser Gly Ser Cys Gln Gln His Gly Ser Val Tyr Trp Ser Arg Thr Ala
            100                 105                 110
 
gaa aaa gtt ttg tct gaa ttg gat gct gaa tct tct ttg tct tct cag   384
Glu Lys Val Leu Ser Glu Leu Asp Ala Glu Ser Ser Leu Ser Ser Gln
        115                 120                 125
 
atg cgt tct gcg ttt acc ttt aaa cat gca ccc aat tgg caa gat cat   432
Met Arg Ser Ala Phe Thr Phe Lys His Ala Pro Asn Trp Gln Asp His
    130                 135                 140
 
tct acc ggt aaa gaa ttg gaa gaa ttt gaa cgt gtc att ggt gct gat   480
Ser Thr Gly Lys Glu Leu Glu Glu Phe Glu Arg Val Ile Gly Ala Asp
145                 150                 155                 160
 
gct tta gca gat atc tct ggt tct cgt gcc cat tat cgt ttt acc ggc   528
Ala Leu Ala Asp Ile Ser Gly Ser Arg Ala His Tyr Arg Phe Thr Gly
                165                 170                 175
 
ttg caa att cgt aaa ttg tct aca cgt ttt aaa cct gaa aag tat aat   576
Leu Gln Ile Arg Lys Leu Ser Thr Arg Phe Lys Pro Glu Lys Tyr Asn
            180                 185                 190
 
cgt act gct cgc att tct ttg gtt tct tct ttt gtt gcc tct gtt ttg   624
Arg Thr Ala Arg Ile Ser Leu Val Ser Ser Phe Val Ala Ser Val Leu
        195                 200                 205
 
ttg ggt cgt att acc tct att gaa gag gcc gat gca tgt ggt atg aat   672
Leu Gly Arg Ile Thr Ser Ile Glu Glu Ala Asp Ala Cys Gly Met Asn
    210                 215                 220
 
ttg tat gat atc gaa aaa cgg gaa ttt aat gaa gaa ttg tta gcc att   720
Leu Tyr Asp Ile Glu Lys Arg Glu Phe Asn Glu Glu Leu Leu Ala Ile
225                 230                 235                 240
 
gct gca ggt gtt cat ccc gaa ctc gac ggt gtt gaa cag gat gga gaa   768
Ala Ala Gly Val His Pro Glu Leu Asp Gly Val Glu Gln Asp Gly Glu
                245                 250                 255
 
att tat cgt gct ggt ata aac gaa ttg aaa cgt aaa ttg ggt ccg gtt   816
Ile Tyr Arg Ala Gly Ile Asn Glu Leu Lys Arg Lys Leu Gly Pro Val
            260                 265                 270
 
aaa ccc att act tat gaa tct gaa ggt gat ata gca tct tat ttt gtt   864
Lys Pro Ile Thr Tyr Glu Ser Glu Gly Asp Ile Ala Ser Tyr Phe Val
        275                 280                 285
 
acc cgg tat ggt ttt aat ccc gat tgt aaa att tat tct ttt acg gga   912
Thr Arg Tyr Gly Phe Asn Pro Asp Cys Lys Ile Tyr Ser Phe Thr Gly
    290                 295                 300
 
gat aat ctt gca aca att att tct ttg ccg ttg gct cca aat gat gct   960
Asp Asn Leu Ala Thr Ile Ile Ser Leu Pro Leu Ala Pro Asn Asp Ala
305                 310                 315                 320
 
cta att tct cta ggt acg tct acc acc gtt ttg att att acc aaa aat   1008
Leu Ile Ser Leu Gly Thr Ser Thr Thr Val Leu Ile Ile Thr Lys Asn
                325                 330                 335
 
tat gcc cca tct tct cag tat cat ttg ttt aaa cat ccg acc atg cct   1056
Tyr Ala Pro Ser Ser Gln Tyr His Leu Phe Lys His Pro Thr Met Pro
            340                 345                 350
 
gac cat tat atg ggt atg atc tgt tat tgt aat ggt tct ttg gct cgg   1104
Asp His Tyr Met Gly Met Ile Cys Tyr Cys Asn Gly Ser Leu Ala Arg
        355                 360                 365
 
gaa aaa gtt aga gat gaa gtc aat gaa aaa ttt aat gtt gaa gat aaa   1152
Glu Lys Val Arg Asp Glu Val Asn Glu Lys Phe Asn Val Glu Asp Lys
    370                 375                 380
 
aag tct tgg gat aaa ttt aat gaa att ttg gat aaa tct acc gat ttt   1200
Lys Ser Trp Asp Lys Phe Asn Glu Ile Leu Asp Lys Ser Thr Asp Phe
385                 390                 395                 400
 
aat aat aaa ttg ggc atc tat ttt ccg cta ggt gaa att gtt ccg aat   1248
Asn Asn Lys Leu Gly Ile Tyr Phe Pro Leu Gly Glu Ile Val Pro Asn
                405                 410                 415
 
gct gct gcc cag att aaa cgt agt gtt ctt aat tct aaa aat gaa att   1296
Ala Ala Ala Gln Ile Lys Arg Ser Val Leu Asn Ser Lys Asn Glu Ile
            420                 425                 430
 
gtt gat gtt gaa ttg gga gat aaa aac tgg caa ccg gaa gat gac gtt   1344
Val Asp Val Glu Leu Gly Asp Lys Asn Trp Gln Pro Glu Asp Asp Val
        435                 440                 445
 
tct tct ata gta gaa tct cag acc ttg tct tgt cgt ttg cgt acg ggt   1392
Ser Ser Ile Val Glu Ser Gln Thr Leu Ser Cys Arg Leu Arg Thr Gly
    450                 455                 460
 
cct atg ttg tct aaa tct ggt gat tct agc gca agt tct tct gcc tct   1440
Pro Met Leu Ser Lys Ser Gly Asp Ser Ser Ala Ser Ser Ser Ala Ser
465                 470                 475                 480
 
ccg caa cct gag ggt gat gga acg gat ttg cat aaa gtt tat cag gat   1488
Pro Gln Pro Glu Gly Asp Gly Thr Asp Leu His Lys Val Tyr Gln Asp
                485                 490                 495
 
ttg gtt aaa aag ttt ggt gat ttg ttt acc gat ggt aag aaa cag acc   1536
Leu Val Lys Lys Phe Gly Asp Leu Phe Thr Asp Gly Lys Lys Gln Thr
            500                 505                 510
 
ttt gaa tct ttg acc gct cgt cct aat cgt tgt tat tat gtc gga ggt   1584
Phe Glu Ser Leu Thr Ala Arg Pro Asn Arg Cys Tyr Tyr Val Gly Gly
        515                 520                 525
 
gct agt aat aat ggt tct att att aaa atg ggt tct att ctt gca cct   1632
Ala Ser Asn Asn Gly Ser Ile Ile Lys Met Gly Ser Ile Leu Ala Pro
    530                 535                 540
 
gtt aat ggt aat tat aaa gtt gac att cct aat gcg tgt gca ctg gga   1680
Val Asn Gly Asn Tyr Lys Val Asp Ile Pro Asn Ala Cys Ala Leu Gly
545                 550                 555                 560
 
gga gca tat aaa gcc tct tgg tct tat gaa tgt gaa gct aaa aag gaa   1728
Gly Ala Tyr Lys Ala Ser Trp Ser Tyr Glu Cys Glu Ala Lys Lys Glu
                565                 570                 575
 
tgg att ggt tat gat cag tat att aat cgt ttg ttt gaa gtt tct gat   1776
Trp Ile Gly Tyr Asp Gln Tyr Ile Asn Arg Leu Phe Glu Val Ser Asp
            580                 585                 590
 
gaa atg aat ttg ttt gag gtc aag gac aaa tgg ttg gaa tat gct aat   1824
Glu Met Asn Leu Phe Glu Val Lys Asp Lys Trp Leu Glu Tyr Ala Asn
        595                 600                 605
 
ggt gtt ggt atg ctt gcg aaa atg gaa tct gaa ttg aaa cat           1866
Gly Val Gly Met Leu Ala Lys Met Glu Ser Glu Leu Lys His
    610                 615                 620
 


<210> 96
<211> 622
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in Z. mobilis

<400> 96
Met Thr Thr Thr Pro Phe Asp Ala Pro Asp Lys Leu Phe Leu Gly Phe
 1               5                  10                  15      
Asp Leu Ser Thr Gln Gln Leu Lys Ile Ile Val Thr Asp Glu Asn Leu
            20                  25                  30          
Ala Ala Leu Lys Thr Tyr Asn Val Glu Phe Asp Ser Ile Asn Ser Ser
        35                  40                  45              
Val Gln Lys Gly Val Ile Ala Ile Asn Asp Glu Ile Ser Lys Gly Ala
    50                  55                  60                  
Ile Ile Ser Pro Val Tyr Met Trp Leu Asp Ala Leu Asp His Val Phe
65                  70                  75                  80  
Glu Asp Met Lys Lys Asp Gly Phe Pro Phe Asn Lys Val Val Gly Ile
                85                  90                  95      
Ser Gly Ser Cys Gln Gln His Gly Ser Val Tyr Trp Ser Arg Thr Ala
            100                 105                 110         
Glu Lys Val Leu Ser Glu Leu Asp Ala Glu Ser Ser Leu Ser Ser Gln
        115                 120                 125             
Met Arg Ser Ala Phe Thr Phe Lys His Ala Pro Asn Trp Gln Asp His
    130                 135                 140                 
Ser Thr Gly Lys Glu Leu Glu Glu Phe Glu Arg Val Ile Gly Ala Asp
145                 150                 155                 160 
Ala Leu Ala Asp Ile Ser Gly Ser Arg Ala His Tyr Arg Phe Thr Gly
                165                 170                 175     
Leu Gln Ile Arg Lys Leu Ser Thr Arg Phe Lys Pro Glu Lys Tyr Asn
            180                 185                 190         
Arg Thr Ala Arg Ile Ser Leu Val Ser Ser Phe Val Ala Ser Val Leu
        195                 200                 205             
Leu Gly Arg Ile Thr Ser Ile Glu Glu Ala Asp Ala Cys Gly Met Asn
    210                 215                 220                 
Leu Tyr Asp Ile Glu Lys Arg Glu Phe Asn Glu Glu Leu Leu Ala Ile
225                 230                 235                 240 
Ala Ala Gly Val His Pro Glu Leu Asp Gly Val Glu Gln Asp Gly Glu
                245                 250                 255     
Ile Tyr Arg Ala Gly Ile Asn Glu Leu Lys Arg Lys Leu Gly Pro Val
            260                 265                 270         
Lys Pro Ile Thr Tyr Glu Ser Glu Gly Asp Ile Ala Ser Tyr Phe Val
        275                 280                 285             
Thr Arg Tyr Gly Phe Asn Pro Asp Cys Lys Ile Tyr Ser Phe Thr Gly
    290                 295                 300                 
Asp Asn Leu Ala Thr Ile Ile Ser Leu Pro Leu Ala Pro Asn Asp Ala
305                 310                 315                 320 
Leu Ile Ser Leu Gly Thr Ser Thr Thr Val Leu Ile Ile Thr Lys Asn
                325                 330                 335     
Tyr Ala Pro Ser Ser Gln Tyr His Leu Phe Lys His Pro Thr Met Pro
            340                 345                 350         
Asp His Tyr Met Gly Met Ile Cys Tyr Cys Asn Gly Ser Leu Ala Arg
        355                 360                 365             
Glu Lys Val Arg Asp Glu Val Asn Glu Lys Phe Asn Val Glu Asp Lys
    370                 375                 380                 
Lys Ser Trp Asp Lys Phe Asn Glu Ile Leu Asp Lys Ser Thr Asp Phe
385                 390                 395                 400 
Asn Asn Lys Leu Gly Ile Tyr Phe Pro Leu Gly Glu Ile Val Pro Asn
                405                 410                 415     
Ala Ala Ala Gln Ile Lys Arg Ser Val Leu Asn Ser Lys Asn Glu Ile
            420                 425                 430         
Val Asp Val Glu Leu Gly Asp Lys Asn Trp Gln Pro Glu Asp Asp Val
        435                 440                 445             
Ser Ser Ile Val Glu Ser Gln Thr Leu Ser Cys Arg Leu Arg Thr Gly
    450                 455                 460                 
Pro Met Leu Ser Lys Ser Gly Asp Ser Ser Ala Ser Ser Ser Ala Ser
465                 470                 475                 480 
Pro Gln Pro Glu Gly Asp Gly Thr Asp Leu His Lys Val Tyr Gln Asp
                485                 490                 495     
Leu Val Lys Lys Phe Gly Asp Leu Phe Thr Asp Gly Lys Lys Gln Thr
            500                 505                 510         
Phe Glu Ser Leu Thr Ala Arg Pro Asn Arg Cys Tyr Tyr Val Gly Gly
        515                 520                 525             
Ala Ser Asn Asn Gly Ser Ile Ile Lys Met Gly Ser Ile Leu Ala Pro
    530                 535                 540                 
Val Asn Gly Asn Tyr Lys Val Asp Ile Pro Asn Ala Cys Ala Leu Gly
545                 550                 555                 560 
Gly Ala Tyr Lys Ala Ser Trp Ser Tyr Glu Cys Glu Ala Lys Lys Glu
                565                 570                 575     
Trp Ile Gly Tyr Asp Gln Tyr Ile Asn Arg Leu Phe Glu Val Ser Asp
            580                 585                 590         
Glu Met Asn Leu Phe Glu Val Lys Asp Lys Trp Leu Glu Tyr Ala Asn
        595                 600                 605             
Gly Val Gly Met Leu Ala Lys Met Glu Ser Glu Leu Lys His
    610                 615                 620         


<210> 97
<211> 1134
<212> DNA
<213> T. reesei

<220> 
<221> CDS            
<222> (1)...(1134)

<400> 97
atg tcg cct tcc gca gtc gat gac gct ccc aag gcc aca ggg gca gcc   48
Met Ser Pro Ser Ala Val Asp Asp Ala Pro Lys Ala Thr Gly Ala Ala
 1               5                   10                  15
 
atc tca gtc aag ccc aac att ggc gtc ttc aca aat cca aaa cat gac   96
Ile Ser Val Lys Pro Asn Ile Gly Val Phe Thr Asn Pro Lys His Asp
             20                  25                  30
 
ctc tgg att agc gaa gct gaa ccc agc gcc gat gcc gtc aaa tct ggc   144
Leu Trp Ile Ser Glu Ala Glu Pro Ser Ala Asp Ala Val Lys Ser Gly
         35                  40                  45
 
gct gat ctg aag ccc ggc gag gtg acc att gct gtc cgc agc act ggt   192
Ala Asp Leu Lys Pro Gly Glu Val Thr Ile Ala Val Arg Ser Thr Gly
     50                  55                  60
 
atc tgt ggt tca gat gtc cat ttc tgg cac gcc ggc tgc att ggg ccc   240
Ile Cys Gly Ser Asp Val His Phe Trp His Ala Gly Cys Ile Gly Pro
 65                  70                  75                  80
 
atg atc gtc gag ggc gac cac atc ctc ggc cac gag tct gcc ggc gag   288
Met Ile Val Glu Gly Asp His Ile Leu Gly His Glu Ser Ala Gly Glu
                 85                  90                  95
 
gtc atc gcc gtc cac ccg act gtc agt agc ctc caa atc ggc gat cgg   336
Val Ile Ala Val His Pro Thr Val Ser Ser Leu Gln Ile Gly Asp Arg
            100                 105                 110
 
gtt gcc atc gag ccc aac atc atc tgc aac gca tgc gag ccc tgc ctg   384
Val Ala Ile Glu Pro Asn Ile Ile Cys Asn Ala Cys Glu Pro Cys Leu
        115                 120                 125
 
aca ggt cga tac aac ggc tgc gaa aag gtc gag ttc cta tcc acg ccg   432
Thr Gly Arg Tyr Asn Gly Cys Glu Lys Val Glu Phe Leu Ser Thr Pro
    130                 135                 140
 
cca gtg ccc gga ctg ctg cga cgc tac gtc aac cac cca gcc gtt tgg   480
Pro Val Pro Gly Leu Leu Arg Arg Tyr Val Asn His Pro Ala Val Trp
145                 150                 155                 160
 
tgc cac aag att ggc aac atg tcg tgg gag aac ggc gcg ctg ctg gag   528
Cys His Lys Ile Gly Asn Met Ser Trp Glu Asn Gly Ala Leu Leu Glu
                165                 170                 175
 
ccc ctg agc gtg gct ctg gcc ggc atg cag agg gcc aag gtt cag ctc   576
Pro Leu Ser Val Ala Leu Ala Gly Met Gln Arg Ala Lys Val Gln Leu
            180                 185                 190
 
ggt gac ccc gtg ctg gtc tgc ggc gct ggt ccg att gga ttg gtg tca   624
Gly Asp Pro Val Leu Val Cys Gly Ala Gly Pro Ile Gly Leu Val Ser
        195                 200                 205
 
atg ctg tgc gct gct gcc gcc ggt gct tgc ccg ctt gtc atc aca gac   672
Met Leu Cys Ala Ala Ala Ala Gly Ala Cys Pro Leu Val Ile Thr Asp
    210                 215                 220
 
att tca gag agc cgt ctg gcg ttt gca aag gag atc tgc ccc cgc gtc   720
Ile Ser Glu Ser Arg Leu Ala Phe Ala Lys Glu Ile Cys Pro Arg Val
225                 230                 235                 240
 
acc acg cac cgc atc gag att ggc aag tcg gct gag gaa acg gcc aaa   768
Thr Thr His Arg Ile Glu Ile Gly Lys Ser Ala Glu Glu Thr Ala Lys
                245                 250                 255
 
agc atc gtc agc tct ttt ggg ggc gtc gag cca gcc gtg acc ctg gag   816
Ser Ile Val Ser Ser Phe Gly Gly Val Glu Pro Ala Val Thr Leu Glu
            260                 265                 270
 
tgc acc ggt gtg gag agc agc att gca gcg gcc atc tgg gcc agc aag   864
Cys Thr Gly Val Glu Ser Ser Ile Ala Ala Ala Ile Trp Ala Ser Lys
        275                 280                 285
 
ttt gga gga aag gtc ttt gtg atc ggc gtc ggc aag aat gaa atc agc   912
Phe Gly Gly Lys Val Phe Val Ile Gly Val Gly Lys Asn Glu Ile Ser
    290                 295                 300
 
att ccc ttt atg agg gcc agt gta cgc gag gtc gat atc cag ctg cag   960
Ile Pro Phe Met Arg Ala Ser Val Arg Glu Val Asp Ile Gln Leu Gln
305                 310                 315                 320
 
tat cgc tac agc aac acc tgg cct cgt gcc atc cgg ctc atc gag agc   1008
Tyr Arg Tyr Ser Asn Thr Trp Pro Arg Ala Ile Arg Leu Ile Glu Ser
                325                 330                 335
 
ggt gtc atc gat cta tcc aaa ttt gtg acg cat cgc ttc ccg ctg gag   1056
Gly Val Ile Asp Leu Ser Lys Phe Val Thr His Arg Phe Pro Leu Glu
            340                 345                 350
 
gat gcc gtc aag gca ttt gag acg tca gca gat ccc aag agc ggc gcc   1104
Asp Ala Val Lys Ala Phe Glu Thr Ser Ala Asp Pro Lys Ser Gly Ala
        355                 360                 365
 
att aag gtc atg att cag agc ctg gat tga                           1134
Ile Lys Val Met Ile Gln Ser Leu Asp  *
    370                 375
 

<210> 98
<211> 377
<212> PRT
<213> T. reesei

<400> 98
Met Ser Pro Ser Ala Val Asp Asp Ala Pro Lys Ala Thr Gly Ala Ala
 1               5                  10                  15      
Ile Ser Val Lys Pro Asn Ile Gly Val Phe Thr Asn Pro Lys His Asp
            20                  25                  30          
Leu Trp Ile Ser Glu Ala Glu Pro Ser Ala Asp Ala Val Lys Ser Gly
        35                  40                  45              
Ala Asp Leu Lys Pro Gly Glu Val Thr Ile Ala Val Arg Ser Thr Gly
    50                  55                  60                  
Ile Cys Gly Ser Asp Val His Phe Trp His Ala Gly Cys Ile Gly Pro
65                  70                  75                  80  
Met Ile Val Glu Gly Asp His Ile Leu Gly His Glu Ser Ala Gly Glu
                85                  90                  95      
Val Ile Ala Val His Pro Thr Val Ser Ser Leu Gln Ile Gly Asp Arg
            100                 105                 110         
Val Ala Ile Glu Pro Asn Ile Ile Cys Asn Ala Cys Glu Pro Cys Leu
        115                 120                 125             
Thr Gly Arg Tyr Asn Gly Cys Glu Lys Val Glu Phe Leu Ser Thr Pro
    130                 135                 140                 
Pro Val Pro Gly Leu Leu Arg Arg Tyr Val Asn His Pro Ala Val Trp
145                 150                 155                 160 
Cys His Lys Ile Gly Asn Met Ser Trp Glu Asn Gly Ala Leu Leu Glu
                165                 170                 175     
Pro Leu Ser Val Ala Leu Ala Gly Met Gln Arg Ala Lys Val Gln Leu
            180                 185                 190         
Gly Asp Pro Val Leu Val Cys Gly Ala Gly Pro Ile Gly Leu Val Ser
        195                 200                 205             
Met Leu Cys Ala Ala Ala Ala Gly Ala Cys Pro Leu Val Ile Thr Asp
    210                 215                 220                 
Ile Ser Glu Ser Arg Leu Ala Phe Ala Lys Glu Ile Cys Pro Arg Val
225                 230                 235                 240 
Thr Thr His Arg Ile Glu Ile Gly Lys Ser Ala Glu Glu Thr Ala Lys
                245                 250                 255     
Ser Ile Val Ser Ser Phe Gly Gly Val Glu Pro Ala Val Thr Leu Glu
            260                 265                 270         
Cys Thr Gly Val Glu Ser Ser Ile Ala Ala Ala Ile Trp Ala Ser Lys
        275                 280                 285             
Phe Gly Gly Lys Val Phe Val Ile Gly Val Gly Lys Asn Glu Ile Ser
    290                 295                 300                 
Ile Pro Phe Met Arg Ala Ser Val Arg Glu Val Asp Ile Gln Leu Gln
305                 310                 315                 320 
Tyr Arg Tyr Ser Asn Thr Trp Pro Arg Ala Ile Arg Leu Ile Glu Ser
                325                 330                 335     
Gly Val Ile Asp Leu Ser Lys Phe Val Thr His Arg Phe Pro Leu Glu
            340                 345                 350         
Asp Ala Val Lys Ala Phe Glu Thr Ser Ala Asp Pro Lys Ser Gly Ala
        355                 360                 365             
Ile Lys Val Met Ile Gln Ser Leu Asp
    370                 375         


<210> 99
<211> 1131
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in S. cerevisiae

<220> 
<221> CDS            
<222> (1)...(1131)

<400> 99
atg tct cct tct gct gtt gat gat gcc cca aaa gct aca ggt gct gct   48
Met Ser Pro Ser Ala Val Asp Asp Ala Pro Lys Ala Thr Gly Ala Ala
 1               5                   10                  15
 
att tct gtt aaa cca aat ata ggt gtt ttt act aat cca aaa cat gat   96
Ile Ser Val Lys Pro Asn Ile Gly Val Phe Thr Asn Pro Lys His Asp
             20                  25                  30
 
ttg tgg att tct gaa gct gaa cca tct gct gat gct gtt aaa tct gga   144
Leu Trp Ile Ser Glu Ala Glu Pro Ser Ala Asp Ala Val Lys Ser Gly
         35                  40                  45
 
gct gat tta aaa cca ggt gaa gtt act att gct gtt aga tca act gga   192
Ala Asp Leu Lys Pro Gly Glu Val Thr Ile Ala Val Arg Ser Thr Gly
     50                  55                  60
 
att tgt ggt tct gat gtt cat ttt tgg cac gct ggt tgt att ggt cca   240
Ile Cys Gly Ser Asp Val His Phe Trp His Ala Gly Cys Ile Gly Pro
 65                  70                  75                  80
 
atg att gtt gaa ggt gat cat att ttg ggt cat gaa tct gct ggt gaa   288
Met Ile Val Glu Gly Asp His Ile Leu Gly His Glu Ser Ala Gly Glu
                 85                  90                  95
 
gta att gct gtt cat cca act gtt tca tct ttg caa att ggt gat aga   336
Val Ile Ala Val His Pro Thr Val Ser Ser Leu Gln Ile Gly Asp Arg
            100                 105                 110
 
gtg gct att gaa cca aat ata att tgt aat gca tgt gaa cca tgt ttg   384
Val Ala Ile Glu Pro Asn Ile Ile Cys Asn Ala Cys Glu Pro Cys Leu
        115                 120                 125
 
act ggt aga tat aat ggt tgt gaa aag gtt gaa ttt ttg tca act cca   432
Thr Gly Arg Tyr Asn Gly Cys Glu Lys Val Glu Phe Leu Ser Thr Pro
    130                 135                 140
 
cca gtt cca ggt ttg ttg aga agg tat gtt aat cat ccc gct gtt tgg   480
Pro Val Pro Gly Leu Leu Arg Arg Tyr Val Asn His Pro Ala Val Trp
145                 150                 155                 160
 
tgt cat aaa att ggt aat atg tct tgg gaa aat ggt gct ttg ttg gaa   528
Cys His Lys Ile Gly Asn Met Ser Trp Glu Asn Gly Ala Leu Leu Glu
                165                 170                 175
 
cca tta tct gtt gca ttg gct ggt atg caa aga gct aaa gta caa ttg   576
Pro Leu Ser Val Ala Leu Ala Gly Met Gln Arg Ala Lys Val Gln Leu
            180                 185                 190
 
ggt gat cca gtt ttg gtt tgt ggt gct ggt cct att ggt ttg gtt tca   624
Gly Asp Pro Val Leu Val Cys Gly Ala Gly Pro Ile Gly Leu Val Ser
        195                 200                 205
 
atg ttg tgt gct gct gcg gct gga gct tgt cca ttg gtt ata act gac   672
Met Leu Cys Ala Ala Ala Ala Gly Ala Cys Pro Leu Val Ile Thr Asp
    210                 215                 220
 
att tct gaa tct aga ttg gct ttt gct aaa gaa att tgt cct aga gtt   720
Ile Ser Glu Ser Arg Leu Ala Phe Ala Lys Glu Ile Cys Pro Arg Val
225                 230                 235                 240
 
act act cat aga att gaa att ggt aaa tct gct gaa gaa act gct aaa   768
Thr Thr His Arg Ile Glu Ile Gly Lys Ser Ala Glu Glu Thr Ala Lys
                245                 250                 255
 
tct att gta tct tct ttt gga ggt gtt gaa cca gct gtt act cta gaa   816
Ser Ile Val Ser Ser Phe Gly Gly Val Glu Pro Ala Val Thr Leu Glu
            260                 265                 270
 
tgt act ggt gtt gaa tct tct att gct gct gct att tgg gct tct aaa   864
Cys Thr Gly Val Glu Ser Ser Ile Ala Ala Ala Ile Trp Ala Ser Lys
        275                 280                 285
 
ttc ggt ggt aaa gta ttt gta att ggt gtt ggg aaa aat gaa att tct   912
Phe Gly Gly Lys Val Phe Val Ile Gly Val Gly Lys Asn Glu Ile Ser
    290                 295                 300
 
att cca ttt atg aga gct tct gtt aga gaa gtt gat ata caa ttg caa   960
Ile Pro Phe Met Arg Ala Ser Val Arg Glu Val Asp Ile Gln Leu Gln
305                 310                 315                 320
 
tat aga tat tct aat act tgg cct aga gct att aga ttg att gaa tct   1008
Tyr Arg Tyr Ser Asn Thr Trp Pro Arg Ala Ile Arg Leu Ile Glu Ser
                325                 330                 335
 
ggt gta att gat ttg tct aaa ttt gta act cat aga ttt cca ttg gaa   1056
Gly Val Ile Asp Leu Ser Lys Phe Val Thr His Arg Phe Pro Leu Glu
            340                 345                 350
 
gat gct gtt aag gct ttt gaa act tct gct gat cca aaa tct ggt gct   1104
Asp Ala Val Lys Ala Phe Glu Thr Ser Ala Asp Pro Lys Ser Gly Ala
        355                 360                 365
 
att aaa gta atg att cag tct ttg gat                               1131
Ile Lys Val Met Ile Gln Ser Leu Asp
    370                 375
 

<210> 100
<211> 377
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in S. cerevisiae

<400> 100
Met Ser Pro Ser Ala Val Asp Asp Ala Pro Lys Ala Thr Gly Ala Ala
 1               5                  10                  15      
Ile Ser Val Lys Pro Asn Ile Gly Val Phe Thr Asn Pro Lys His Asp
            20                  25                  30          
Leu Trp Ile Ser Glu Ala Glu Pro Ser Ala Asp Ala Val Lys Ser Gly
        35                  40                  45              
Ala Asp Leu Lys Pro Gly Glu Val Thr Ile Ala Val Arg Ser Thr Gly
    50                  55                  60                  
Ile Cys Gly Ser Asp Val His Phe Trp His Ala Gly Cys Ile Gly Pro
65                  70                  75                  80  
Met Ile Val Glu Gly Asp His Ile Leu Gly His Glu Ser Ala Gly Glu
                85                  90                  95      
Val Ile Ala Val His Pro Thr Val Ser Ser Leu Gln Ile Gly Asp Arg
            100                 105                 110         
Val Ala Ile Glu Pro Asn Ile Ile Cys Asn Ala Cys Glu Pro Cys Leu
        115                 120                 125             
Thr Gly Arg Tyr Asn Gly Cys Glu Lys Val Glu Phe Leu Ser Thr Pro
    130                 135                 140                 
Pro Val Pro Gly Leu Leu Arg Arg Tyr Val Asn His Pro Ala Val Trp
145                 150                 155                 160 
Cys His Lys Ile Gly Asn Met Ser Trp Glu Asn Gly Ala Leu Leu Glu
                165                 170                 175     
Pro Leu Ser Val Ala Leu Ala Gly Met Gln Arg Ala Lys Val Gln Leu
            180                 185                 190         
Gly Asp Pro Val Leu Val Cys Gly Ala Gly Pro Ile Gly Leu Val Ser
        195                 200                 205             
Met Leu Cys Ala Ala Ala Ala Gly Ala Cys Pro Leu Val Ile Thr Asp
    210                 215                 220                 
Ile Ser Glu Ser Arg Leu Ala Phe Ala Lys Glu Ile Cys Pro Arg Val
225                 230                 235                 240 
Thr Thr His Arg Ile Glu Ile Gly Lys Ser Ala Glu Glu Thr Ala Lys
                245                 250                 255     
Ser Ile Val Ser Ser Phe Gly Gly Val Glu Pro Ala Val Thr Leu Glu
            260                 265                 270         
Cys Thr Gly Val Glu Ser Ser Ile Ala Ala Ala Ile Trp Ala Ser Lys
        275                 280                 285             
Phe Gly Gly Lys Val Phe Val Ile Gly Val Gly Lys Asn Glu Ile Ser
    290                 295                 300                 
Ile Pro Phe Met Arg Ala Ser Val Arg Glu Val Asp Ile Gln Leu Gln
305                 310                 315                 320 
Tyr Arg Tyr Ser Asn Thr Trp Pro Arg Ala Ile Arg Leu Ile Glu Ser
                325                 330                 335     
Gly Val Ile Asp Leu Ser Lys Phe Val Thr His Arg Phe Pro Leu Glu
            340                 345                 350         
Asp Ala Val Lys Ala Phe Glu Thr Ser Ala Asp Pro Lys Ser Gly Ala
        355                 360                 365             
Ile Lys Val Met Ile Gln Ser Leu Asp
    370                 375         


<210> 101
<211> 1153
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in S. cerevisiae

<220> 
<221> CDS            
<222> (12)...(1142)

<400> 101
tactcaagct t atg tct cct tct gct gtt gat gat gcc cca aaa gct aca  50
             Met Ser Pro Ser Ala Val Asp Asp Ala Pro Lys Ala Thr
              1               5                   10
 
ggt gct gct att tct gtt aaa cca aat ata ggt gtt ttt act aat cca   98
Gly Ala Ala Ile Ser Val Lys Pro Asn Ile Gly Val Phe Thr Asn Pro
     15                  20                  25
 
aaa cat gat ttg tgg att tct gaa gct gaa cca tct gct gat gct gtt   146
Lys His Asp Leu Trp Ile Ser Glu Ala Glu Pro Ser Ala Asp Ala Val
 30                  35                  40                  45
 
aaa tct gga gct gat tta aaa cca ggt gaa gtt act att gct gtt aga   194
Lys Ser Gly Ala Asp Leu Lys Pro Gly Glu Val Thr Ile Ala Val Arg
                 50                  55                  60
 
tca act gga att tgt ggt tct gat gtt cat ttt tgg cac gct ggt tgt   242
Ser Thr Gly Ile Cys Gly Ser Asp Val His Phe Trp His Ala Gly Cys
             65                  70                  75
 
att ggt cca atg att gtt gaa ggt gat cat att ttg ggt cat gaa tct   290
Ile Gly Pro Met Ile Val Glu Gly Asp His Ile Leu Gly His Glu Ser
         80                  85                  90
 
gct ggt gaa gta att gct gtt cat cca act gtt tca tct ttg caa att   338
Ala Gly Glu Val Ile Ala Val His Pro Thr Val Ser Ser Leu Gln Ile
     95                 100                 105
 
ggt gat aga gtg gct att gaa cca aat ata att tgt aat gca tgt gaa   386
Gly Asp Arg Val Ala Ile Glu Pro Asn Ile Ile Cys Asn Ala Cys Glu
110                 115                 120                 125
 
cca tgt ttg act ggt aga tat aat ggt tgt gaa aag gtt gaa ttt ttg   434
Pro Cys Leu Thr Gly Arg Tyr Asn Gly Cys Glu Lys Val Glu Phe Leu
                130                 135                 140
 
tca act cca cca gtt cca ggt ttg ttg aga agg tat gtt aat cat ccc   482
Ser Thr Pro Pro Val Pro Gly Leu Leu Arg Arg Tyr Val Asn His Pro
            145                 150                 155
 
gct gtt tgg tgt cat aaa att ggt aat atg tct tgg gaa aat ggt gct   530
Ala Val Trp Cys His Lys Ile Gly Asn Met Ser Trp Glu Asn Gly Ala
        160                 165                 170
 
ttg ttg gaa cca tta tct gtt gca ttg gct ggt atg caa aga gct aaa   578
Leu Leu Glu Pro Leu Ser Val Ala Leu Ala Gly Met Gln Arg Ala Lys
    175                 180                 185
 
gta caa ttg ggt gat cca gtt ttg gtt tgt ggt gct ggt cct att ggt   626
Val Gln Leu Gly Asp Pro Val Leu Val Cys Gly Ala Gly Pro Ile Gly
190                 195                 200                 205
 
ttg gtt tca atg ttg tgt gct gct gcg gct gga gct tgt cca ttg gtt   674
Leu Val Ser Met Leu Cys Ala Ala Ala Ala Gly Ala Cys Pro Leu Val
                210                 215                 220
 
ata act gac att tct gaa tct aga ttg gct ttt gct aaa gaa att tgt   722
Ile Thr Asp Ile Ser Glu Ser Arg Leu Ala Phe Ala Lys Glu Ile Cys
            225                 230                 235
 
cct aga gtt act act cat aga att gaa att ggt aaa tct gct gaa gaa   770
Pro Arg Val Thr Thr His Arg Ile Glu Ile Gly Lys Ser Ala Glu Glu
        240                 245                 250
 
act gct aaa tct att gta tct tct ttt gga ggt gtt gaa cca gct gtt   818
Thr Ala Lys Ser Ile Val Ser Ser Phe Gly Gly Val Glu Pro Ala Val
    255                 260                 265
 
act cta gaa tgt act ggt gtt gaa tct tct att gct gct gct att tgg   866
Thr Leu Glu Cys Thr Gly Val Glu Ser Ser Ile Ala Ala Ala Ile Trp
270                 275                 280                 285
 
gct tct aaa ttc ggt ggt aaa gta ttt gta att ggt gtt ggg aaa aat   914
Ala Ser Lys Phe Gly Gly Lys Val Phe Val Ile Gly Val Gly Lys Asn
                290                 295                 300
 
gaa att tct att cca ttt atg aga gct tct gtt aga gaa gtt gat ata   962
Glu Ile Ser Ile Pro Phe Met Arg Ala Ser Val Arg Glu Val Asp Ile
            305                 310                 315
 
caa ttg caa tat aga tat tct aat act tgg cct aga gct att aga ttg   1010
Gln Leu Gln Tyr Arg Tyr Ser Asn Thr Trp Pro Arg Ala Ile Arg Leu
        320                 325                 330
 
att gaa tct ggt gta att gat ttg tct aaa ttt gta act cat aga ttt   1058
Ile Glu Ser Gly Val Ile Asp Leu Ser Lys Phe Val Thr His Arg Phe
    335                 340                 345
 
cca ttg gaa gat gct gtt aag gct ttt gaa act tct gct gat cca aaa   1106
Pro Leu Glu Asp Ala Val Lys Ala Phe Glu Thr Ser Ala Asp Pro Lys
350                 355                 360                 365
 
tct ggt gct att aaa gta atg att cag tct ttg gat gaattccgat        1152
Ser Gly Ala Ile Lys Val Met Ile Gln Ser Leu Asp
                370                 375
 
g                                                                 1153

<210> 102
<211> 377
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in S. cerevisiae

<400> 102
Met Ser Pro Ser Ala Val Asp Asp Ala Pro Lys Ala Thr Gly Ala Ala
 1               5                  10                  15      
Ile Ser Val Lys Pro Asn Ile Gly Val Phe Thr Asn Pro Lys His Asp
            20                  25                  30          
Leu Trp Ile Ser Glu Ala Glu Pro Ser Ala Asp Ala Val Lys Ser Gly
        35                  40                  45              
Ala Asp Leu Lys Pro Gly Glu Val Thr Ile Ala Val Arg Ser Thr Gly
    50                  55                  60                  
Ile Cys Gly Ser Asp Val His Phe Trp His Ala Gly Cys Ile Gly Pro
65                  70                  75                  80  
Met Ile Val Glu Gly Asp His Ile Leu Gly His Glu Ser Ala Gly Glu
                85                  90                  95      
Val Ile Ala Val His Pro Thr Val Ser Ser Leu Gln Ile Gly Asp Arg
            100                 105                 110         
Val Ala Ile Glu Pro Asn Ile Ile Cys Asn Ala Cys Glu Pro Cys Leu
        115                 120                 125             
Thr Gly Arg Tyr Asn Gly Cys Glu Lys Val Glu Phe Leu Ser Thr Pro
    130                 135                 140                 
Pro Val Pro Gly Leu Leu Arg Arg Tyr Val Asn His Pro Ala Val Trp
145                 150                 155                 160 
Cys His Lys Ile Gly Asn Met Ser Trp Glu Asn Gly Ala Leu Leu Glu
                165                 170                 175     
Pro Leu Ser Val Ala Leu Ala Gly Met Gln Arg Ala Lys Val Gln Leu
            180                 185                 190         
Gly Asp Pro Val Leu Val Cys Gly Ala Gly Pro Ile Gly Leu Val Ser
        195                 200                 205             
Met Leu Cys Ala Ala Ala Ala Gly Ala Cys Pro Leu Val Ile Thr Asp
    210                 215                 220                 
Ile Ser Glu Ser Arg Leu Ala Phe Ala Lys Glu Ile Cys Pro Arg Val
225                 230                 235                 240 
Thr Thr His Arg Ile Glu Ile Gly Lys Ser Ala Glu Glu Thr Ala Lys
                245                 250                 255     
Ser Ile Val Ser Ser Phe Gly Gly Val Glu Pro Ala Val Thr Leu Glu
            260                 265                 270         
Cys Thr Gly Val Glu Ser Ser Ile Ala Ala Ala Ile Trp Ala Ser Lys
        275                 280                 285             
Phe Gly Gly Lys Val Phe Val Ile Gly Val Gly Lys Asn Glu Ile Ser
    290                 295                 300                 
Ile Pro Phe Met Arg Ala Ser Val Arg Glu Val Asp Ile Gln Leu Gln
305                 310                 315                 320 
Tyr Arg Tyr Ser Asn Thr Trp Pro Arg Ala Ile Arg Leu Ile Glu Ser
                325                 330                 335     
Gly Val Ile Asp Leu Ser Lys Phe Val Thr His Arg Phe Pro Leu Glu
            340                 345                 350         
Asp Ala Val Lys Ala Phe Glu Thr Ser Ala Asp Pro Lys Ser Gly Ala
        355                 360                 365             
Ile Lys Val Met Ile Gln Ser Leu Asp
    370                 375         


<210> 103
<211> 1159
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in S. cerevisiae

<220> 
<221> CDS            
<222> (15)...(1145)

<400> 103
gaatactcca tatg atg tct cct tct gct gtt gat gat gcc cca aaa gct   50
                Met Ser Pro Ser Ala Val Asp Asp Ala Pro Lys Ala
                 1               5                   10
 
aca ggt gct gct att tct gtt aaa cca aat ata ggt gtt ttt act aat   98
Thr Gly Ala Ala Ile Ser Val Lys Pro Asn Ile Gly Val Phe Thr Asn
         15                  20                  25
 
cca aaa cat gat ttg tgg att tct gaa gct gaa cca tct gct gat gct   146
Pro Lys His Asp Leu Trp Ile Ser Glu Ala Glu Pro Ser Ala Asp Ala
     30                  35                  40
 
gtt aaa tct gga gct gat tta aaa cca ggt gaa gtt act att gct gtt   194
Val Lys Ser Gly Ala Asp Leu Lys Pro Gly Glu Val Thr Ile Ala Val
 45                  50                  55                  60
 
aga tca act gga att tgt ggt tct gat gtt cat ttt tgg cac gct ggt   242
Arg Ser Thr Gly Ile Cys Gly Ser Asp Val His Phe Trp His Ala Gly
                 65                  70                  75
 
tgt att ggt cca atg att gtt gaa ggt gat cat att ttg ggt cat gaa   290
Cys Ile Gly Pro Met Ile Val Glu Gly Asp His Ile Leu Gly His Glu
             80                  85                  90
 
tct gct ggt gaa gta att gct gtt cat cca act gtt tca tct ttg caa   338
Ser Ala Gly Glu Val Ile Ala Val His Pro Thr Val Ser Ser Leu Gln
         95                 100                 105
 
att ggt gat aga gtg gct att gaa cca aat ata att tgt aat gca tgt   386
Ile Gly Asp Arg Val Ala Ile Glu Pro Asn Ile Ile Cys Asn Ala Cys
    110                 115                 120
 
gaa cca tgt ttg act ggt aga tat aat ggt tgt gaa aag gtt gaa ttt   434
Glu Pro Cys Leu Thr Gly Arg Tyr Asn Gly Cys Glu Lys Val Glu Phe
125                 130                 135                 140
 
ttg tca act cca cca gtt cca ggt ttg ttg aga agg tat gtt aat cat   482
Leu Ser Thr Pro Pro Val Pro Gly Leu Leu Arg Arg Tyr Val Asn His
                145                 150                 155
 
ccc gct gtt tgg tgt cat aaa att ggt aat atg tct tgg gaa aat ggt   530
Pro Ala Val Trp Cys His Lys Ile Gly Asn Met Ser Trp Glu Asn Gly
            160                 165                 170
 
gct ttg ttg gaa cca tta tct gtt gca ttg gct ggt atg caa aga gct   578
Ala Leu Leu Glu Pro Leu Ser Val Ala Leu Ala Gly Met Gln Arg Ala
        175                 180                 185
 
aaa gta caa ttg ggt gat cca gtt ttg gtt tgt ggt gct ggt cct att   626
Lys Val Gln Leu Gly Asp Pro Val Leu Val Cys Gly Ala Gly Pro Ile
    190                 195                 200
 
ggt ttg gtt tca atg ttg tgt gct gct gcg gct gga gct tgt cca ttg   674
Gly Leu Val Ser Met Leu Cys Ala Ala Ala Ala Gly Ala Cys Pro Leu
205                 210                 215                 220
 
gtt ata act gac att tct gaa tct aga ttg gct ttt gct aaa gaa att   722
Val Ile Thr Asp Ile Ser Glu Ser Arg Leu Ala Phe Ala Lys Glu Ile
                225                 230                 235
 
tgt cct aga gtt act act cat aga att gaa att ggt aaa tct gct gaa   770
Cys Pro Arg Val Thr Thr His Arg Ile Glu Ile Gly Lys Ser Ala Glu
            240                 245                 250
 
gaa act gct aaa tct att gta tct tct ttt gga ggt gtt gaa cca gct   818
Glu Thr Ala Lys Ser Ile Val Ser Ser Phe Gly Gly Val Glu Pro Ala
        255                 260                 265
 
gtt act cta gaa tgt act ggt gtt gaa tct tct att gct gct gct att   866
Val Thr Leu Glu Cys Thr Gly Val Glu Ser Ser Ile Ala Ala Ala Ile
    270                 275                 280
 
tgg gct tct aaa ttc ggt ggt aaa gta ttt gta att ggt gtt ggg aaa   914
Trp Ala Ser Lys Phe Gly Gly Lys Val Phe Val Ile Gly Val Gly Lys
285                 290                 295                 300
 
aat gaa att tct att cca ttt atg aga gct tct gtt aga gaa gtt gat   962
Asn Glu Ile Ser Ile Pro Phe Met Arg Ala Ser Val Arg Glu Val Asp
                305                 310                 315
 
ata caa ttg caa tat aga tat tct aat act tgg cct aga gct att aga   1010
Ile Gln Leu Gln Tyr Arg Tyr Ser Asn Thr Trp Pro Arg Ala Ile Arg
            320                 325                 330
 
ttg att gaa tct ggt gta att gat ttg tct aaa ttt gta act cat aga   1058
Leu Ile Glu Ser Gly Val Ile Asp Leu Ser Lys Phe Val Thr His Arg
        335                 340                 345
 
ttt cca ttg gaa gat gct gtt aag gct ttt gaa act tct gct gat cca   1106
Phe Pro Leu Glu Asp Ala Val Lys Ala Phe Glu Thr Ser Ala Asp Pro
    350                 355                 360
 
aaa tct ggt gct att aaa gta atg att cag tct ttg gat actagtcgat    1155
Lys Ser Gly Ala Ile Lys Val Met Ile Gln Ser Leu Asp
365                 370                 375
 
gcct                                                              1159

<210> 104
<211> 377
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in S. cerevisiae

<400> 104
Met Ser Pro Ser Ala Val Asp Asp Ala Pro Lys Ala Thr Gly Ala Ala
 1               5                  10                  15      
Ile Ser Val Lys Pro Asn Ile Gly Val Phe Thr Asn Pro Lys His Asp
            20                  25                  30          
Leu Trp Ile Ser Glu Ala Glu Pro Ser Ala Asp Ala Val Lys Ser Gly
        35                  40                  45              
Ala Asp Leu Lys Pro Gly Glu Val Thr Ile Ala Val Arg Ser Thr Gly
    50                  55                  60                  
Ile Cys Gly Ser Asp Val His Phe Trp His Ala Gly Cys Ile Gly Pro
65                  70                  75                  80  
Met Ile Val Glu Gly Asp His Ile Leu Gly His Glu Ser Ala Gly Glu
                85                  90                  95      
Val Ile Ala Val His Pro Thr Val Ser Ser Leu Gln Ile Gly Asp Arg
            100                 105                 110         
Val Ala Ile Glu Pro Asn Ile Ile Cys Asn Ala Cys Glu Pro Cys Leu
        115                 120                 125             
Thr Gly Arg Tyr Asn Gly Cys Glu Lys Val Glu Phe Leu Ser Thr Pro
    130                 135                 140                 
Pro Val Pro Gly Leu Leu Arg Arg Tyr Val Asn His Pro Ala Val Trp
145                 150                 155                 160 
Cys His Lys Ile Gly Asn Met Ser Trp Glu Asn Gly Ala Leu Leu Glu
                165                 170                 175     
Pro Leu Ser Val Ala Leu Ala Gly Met Gln Arg Ala Lys Val Gln Leu
            180                 185                 190         
Gly Asp Pro Val Leu Val Cys Gly Ala Gly Pro Ile Gly Leu Val Ser
        195                 200                 205             
Met Leu Cys Ala Ala Ala Ala Gly Ala Cys Pro Leu Val Ile Thr Asp
    210                 215                 220                 
Ile Ser Glu Ser Arg Leu Ala Phe Ala Lys Glu Ile Cys Pro Arg Val
225                 230                 235                 240 
Thr Thr His Arg Ile Glu Ile Gly Lys Ser Ala Glu Glu Thr Ala Lys
                245                 250                 255     
Ser Ile Val Ser Ser Phe Gly Gly Val Glu Pro Ala Val Thr Leu Glu
            260                 265                 270         
Cys Thr Gly Val Glu Ser Ser Ile Ala Ala Ala Ile Trp Ala Ser Lys
        275                 280                 285             
Phe Gly Gly Lys Val Phe Val Ile Gly Val Gly Lys Asn Glu Ile Ser
    290                 295                 300                 
Ile Pro Phe Met Arg Ala Ser Val Arg Glu Val Asp Ile Gln Leu Gln
305                 310                 315                 320 
Tyr Arg Tyr Ser Asn Thr Trp Pro Arg Ala Ile Arg Leu Ile Glu Ser
                325                 330                 335     
Gly Val Ile Asp Leu Ser Lys Phe Val Thr His Arg Phe Pro Leu Glu
            340                 345                 350         
Asp Ala Val Lys Ala Phe Glu Thr Ser Ala Asp Pro Lys Ser Gly Ala
        355                 360                 365             
Ile Lys Val Met Ile Gln Ser Leu Asp
    370                 375         


<210> 105
<211> 1131
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in E. coli

<220> 
<221> CDS            
<222> (1)...(1131)

<400> 105
atg tct ccg tct gct gtt gac gac gcg cca aag gct acc ggt gct gca   48
Met Ser Pro Ser Ala Val Asp Asp Ala Pro Lys Ala Thr Gly Ala Ala
 1               5                   10                  15
 
atc tct gtt aaa ccg aac atc ggc gtt ttc acc aac ccg aaa cac gac   96
Ile Ser Val Lys Pro Asn Ile Gly Val Phe Thr Asn Pro Lys His Asp
             20                  25                  30
 
ctg tgg atc tct gaa gct gag cca tct gcg gac gct gtt aaa tct ggt   144
Leu Trp Ile Ser Glu Ala Glu Pro Ser Ala Asp Ala Val Lys Ser Gly
         35                  40                  45
 
gcg gac ctg aaa ccg ggt gaa gtt acc atc gcg gtt cgt tct acc ggt   192
Ala Asp Leu Lys Pro Gly Glu Val Thr Ile Ala Val Arg Ser Thr Gly
     50                  55                  60
 
att tgc ggt tct gat gtt cac ttt tgg cac gcg ggt tgt atc ggt ccg   240
Ile Cys Gly Ser Asp Val His Phe Trp His Ala Gly Cys Ile Gly Pro
 65                  70                  75                  80
 
atg atc gtt gaa ggc gac cac atc ctg ggt cac gaa tct gct ggt gaa   288
Met Ile Val Glu Gly Asp His Ile Leu Gly His Glu Ser Ala Gly Glu
                 85                  90                  95
 
gtt atc gct gtt cac ccg acc gtt agc tct ctc cag atc ggt gac cgt   336
Val Ile Ala Val His Pro Thr Val Ser Ser Leu Gln Ile Gly Asp Arg
            100                 105                 110
 
gtt gcg atc gaa ccg aac atc atc tgc aac gct tgc gaa cca tgc ctg   384
Val Ala Ile Glu Pro Asn Ile Ile Cys Asn Ala Cys Glu Pro Cys Leu
        115                 120                 125
 
acc ggt cgt tat aac ggc tgc gaa aaa gtt gaa ttt ctg tct acc cca   432
Thr Gly Arg Tyr Asn Gly Cys Glu Lys Val Glu Phe Leu Ser Thr Pro
    130                 135                 140
 
cct gtt ccg ggc ctc ctg cgt cgt tac gtt aat cac ccg gcg gtt tgg   480
Pro Val Pro Gly Leu Leu Arg Arg Tyr Val Asn His Pro Ala Val Trp
145                 150                 155                 160
 
tgc cac aaa atc ggt aac atg tct tgg gaa aat ggt gct ctg ctc gaa   528
Cys His Lys Ile Gly Asn Met Ser Trp Glu Asn Gly Ala Leu Leu Glu
                165                 170                 175
 
ccg ctg tct gtt gct ctg gct ggt atg caa cgt gcg aaa gtt cag ctg   576
Pro Leu Ser Val Ala Leu Ala Gly Met Gln Arg Ala Lys Val Gln Leu
            180                 185                 190
 
ggc gac ccg gtt ctg gtt tgc ggt gct ggc cca atc ggt ctg gtt tcg   624
Gly Asp Pro Val Leu Val Cys Gly Ala Gly Pro Ile Gly Leu Val Ser
        195                 200                 205
 
atg ctg tgt gct gct gct gcg ggt gcg tgt cca ctg gtt atc act gac   672
Met Leu Cys Ala Ala Ala Ala Gly Ala Cys Pro Leu Val Ile Thr Asp
    210                 215                 220
 
atc tct gaa tct cgt ctc gcg ttt gcg aaa gaa atc tgt cca cgt gtg   720
Ile Ser Glu Ser Arg Leu Ala Phe Ala Lys Glu Ile Cys Pro Arg Val
225                 230                 235                 240
 
act acc cac cgt atc gaa atc ggt aaa tct gct gag gaa acc gcg aaa   768
Thr Thr His Arg Ile Glu Ile Gly Lys Ser Ala Glu Glu Thr Ala Lys
                245                 250                 255
 
tct atc gtt agc tct ttc ggt ggc gtt gaa cca gct gtt acc ctc gaa   816
Ser Ile Val Ser Ser Phe Gly Gly Val Glu Pro Ala Val Thr Leu Glu
            260                 265                 270
 
tgt acc ggt gtt gaa tct tct atc gcg gct gct att tgg gcg tct aaa   864
Cys Thr Gly Val Glu Ser Ser Ile Ala Ala Ala Ile Trp Ala Ser Lys
        275                 280                 285
 
ttc ggt ggt aaa gtt ttc gtt atc ggt gtt ggt aaa aac gaa atc tct   912
Phe Gly Gly Lys Val Phe Val Ile Gly Val Gly Lys Asn Glu Ile Ser
    290                 295                 300
 
atc ccg ttc atg cgt gcg tct gtt cgt gaa gtt gac atc cag ctc cag   960
Ile Pro Phe Met Arg Ala Ser Val Arg Glu Val Asp Ile Gln Leu Gln
305                 310                 315                 320
 
tac cgt tac tct aac act tgg ccg cgt gct atc cgt ctg atc gaa tct   1008
Tyr Arg Tyr Ser Asn Thr Trp Pro Arg Ala Ile Arg Leu Ile Glu Ser
                325                 330                 335
 
ggt gtt att gac ctg tct aaa ttc gtt acc cac cgt ttc cca ctc gaa   1056
Gly Val Ile Asp Leu Ser Lys Phe Val Thr His Arg Phe Pro Leu Glu
            340                 345                 350
 
gac gcg gtt aag gct ttc gaa acc tct gcg gac ccg aaa tct ggc gct   1104
Asp Ala Val Lys Ala Phe Glu Thr Ser Ala Asp Pro Lys Ser Gly Ala
        355                 360                 365
 
atc aaa gtt atg atc cag tct ctg gac                               1131
Ile Lys Val Met Ile Gln Ser Leu Asp
    370                 375
 

<210> 106
<211> 377
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in E. coli

<400> 106
Met Ser Pro Ser Ala Val Asp Asp Ala Pro Lys Ala Thr Gly Ala Ala
 1               5                  10                  15      
Ile Ser Val Lys Pro Asn Ile Gly Val Phe Thr Asn Pro Lys His Asp
            20                  25                  30          
Leu Trp Ile Ser Glu Ala Glu Pro Ser Ala Asp Ala Val Lys Ser Gly
        35                  40                  45              
Ala Asp Leu Lys Pro Gly Glu Val Thr Ile Ala Val Arg Ser Thr Gly
    50                  55                  60                  
Ile Cys Gly Ser Asp Val His Phe Trp His Ala Gly Cys Ile Gly Pro
65                  70                  75                  80  
Met Ile Val Glu Gly Asp His Ile Leu Gly His Glu Ser Ala Gly Glu
                85                  90                  95      
Val Ile Ala Val His Pro Thr Val Ser Ser Leu Gln Ile Gly Asp Arg
            100                 105                 110         
Val Ala Ile Glu Pro Asn Ile Ile Cys Asn Ala Cys Glu Pro Cys Leu
        115                 120                 125             
Thr Gly Arg Tyr Asn Gly Cys Glu Lys Val Glu Phe Leu Ser Thr Pro
    130                 135                 140                 
Pro Val Pro Gly Leu Leu Arg Arg Tyr Val Asn His Pro Ala Val Trp
145                 150                 155                 160 
Cys His Lys Ile Gly Asn Met Ser Trp Glu Asn Gly Ala Leu Leu Glu
                165                 170                 175     
Pro Leu Ser Val Ala Leu Ala Gly Met Gln Arg Ala Lys Val Gln Leu
            180                 185                 190         
Gly Asp Pro Val Leu Val Cys Gly Ala Gly Pro Ile Gly Leu Val Ser
        195                 200                 205             
Met Leu Cys Ala Ala Ala Ala Gly Ala Cys Pro Leu Val Ile Thr Asp
    210                 215                 220                 
Ile Ser Glu Ser Arg Leu Ala Phe Ala Lys Glu Ile Cys Pro Arg Val
225                 230                 235                 240 
Thr Thr His Arg Ile Glu Ile Gly Lys Ser Ala Glu Glu Thr Ala Lys
                245                 250                 255     
Ser Ile Val Ser Ser Phe Gly Gly Val Glu Pro Ala Val Thr Leu Glu
            260                 265                 270         
Cys Thr Gly Val Glu Ser Ser Ile Ala Ala Ala Ile Trp Ala Ser Lys
        275                 280                 285             
Phe Gly Gly Lys Val Phe Val Ile Gly Val Gly Lys Asn Glu Ile Ser
    290                 295                 300                 
Ile Pro Phe Met Arg Ala Ser Val Arg Glu Val Asp Ile Gln Leu Gln
305                 310                 315                 320 
Tyr Arg Tyr Ser Asn Thr Trp Pro Arg Ala Ile Arg Leu Ile Glu Ser
                325                 330                 335     
Gly Val Ile Asp Leu Ser Lys Phe Val Thr His Arg Phe Pro Leu Glu
            340                 345                 350         
Asp Ala Val Lys Ala Phe Glu Thr Ser Ala Asp Pro Lys Ser Gly Ala
        355                 360                 365             
Ile Lys Val Met Ile Gln Ser Leu Asp
    370                 375         


<210> 107
<211> 1153
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in E. coli

<220> 
<221> CDS            
<222> (12)...(1142)

<400> 107
tactcaagct t atg tct ccg tct gct gtt gac gac gcg cca aag gct acc  50
             Met Ser Pro Ser Ala Val Asp Asp Ala Pro Lys Ala Thr
              1               5                   10
 
ggt gct gca atc tct gtt aaa ccg aac atc ggc gtt ttc acc aac ccg   98
Gly Ala Ala Ile Ser Val Lys Pro Asn Ile Gly Val Phe Thr Asn Pro
     15                  20                  25
 
aaa cac gac ctg tgg atc tct gaa gct gag cca tct gcg gac gct gtt   146
Lys His Asp Leu Trp Ile Ser Glu Ala Glu Pro Ser Ala Asp Ala Val
 30                  35                  40                  45
 
aaa tct ggt gcg gac ctg aaa ccg ggt gaa gtt acc atc gcg gtt cgt   194
Lys Ser Gly Ala Asp Leu Lys Pro Gly Glu Val Thr Ile Ala Val Arg
                 50                  55                  60
 
tct acc ggt att tgc ggt tct gat gtt cac ttt tgg cac gcg ggt tgt   242
Ser Thr Gly Ile Cys Gly Ser Asp Val His Phe Trp His Ala Gly Cys
             65                  70                  75
 
atc ggt ccg atg atc gtt gaa ggc gac cac atc ctg ggt cac gaa tct   290
Ile Gly Pro Met Ile Val Glu Gly Asp His Ile Leu Gly His Glu Ser
         80                  85                  90
 
gct ggt gaa gtt atc gct gtt cac ccg acc gtt agc tct ctc cag atc   338
Ala Gly Glu Val Ile Ala Val His Pro Thr Val Ser Ser Leu Gln Ile
     95                 100                 105
 
ggt gac cgt gtt gcg atc gaa ccg aac atc atc tgc aac gct tgc gaa   386
Gly Asp Arg Val Ala Ile Glu Pro Asn Ile Ile Cys Asn Ala Cys Glu
110                 115                 120                 125
 
cca tgc ctg acc ggt cgt tat aac ggc tgc gaa aaa gtt gaa ttt ctg   434
Pro Cys Leu Thr Gly Arg Tyr Asn Gly Cys Glu Lys Val Glu Phe Leu
                130                 135                 140
 
tct acc cca cct gtt ccg ggc ctc ctg cgt cgt tac gtt aat cac ccg   482
Ser Thr Pro Pro Val Pro Gly Leu Leu Arg Arg Tyr Val Asn His Pro
            145                 150                 155
 
gcg gtt tgg tgc cac aaa atc ggt aac atg tct tgg gaa aat ggt gct   530
Ala Val Trp Cys His Lys Ile Gly Asn Met Ser Trp Glu Asn Gly Ala
        160                 165                 170
 
ctg ctc gaa ccg ctg tct gtt gct ctg gct ggt atg caa cgt gcg aaa   578
Leu Leu Glu Pro Leu Ser Val Ala Leu Ala Gly Met Gln Arg Ala Lys
    175                 180                 185
 
gtt cag ctg ggc gac ccg gtt ctg gtt tgc ggt gct ggc cca atc ggt   626
Val Gln Leu Gly Asp Pro Val Leu Val Cys Gly Ala Gly Pro Ile Gly
190                 195                 200                 205
 
ctg gtt tcg atg ctg tgt gct gct gct gcg ggt gcg tgt cca ctg gtt   674
Leu Val Ser Met Leu Cys Ala Ala Ala Ala Gly Ala Cys Pro Leu Val
                210                 215                 220
 
atc act gac atc tct gaa tct cgt ctc gcg ttt gcg aaa gaa atc tgt   722
Ile Thr Asp Ile Ser Glu Ser Arg Leu Ala Phe Ala Lys Glu Ile Cys
            225                 230                 235
 
cca cgt gtg act acc cac cgt atc gaa atc ggt aaa tct gct gag gaa   770
Pro Arg Val Thr Thr His Arg Ile Glu Ile Gly Lys Ser Ala Glu Glu
        240                 245                 250
 
acc gcg aaa tct atc gtt agc tct ttc ggt ggc gtt gaa cca gct gtt   818
Thr Ala Lys Ser Ile Val Ser Ser Phe Gly Gly Val Glu Pro Ala Val
    255                 260                 265
 
acc ctc gaa tgt acc ggt gtt gaa tct tct atc gcg gct gct att tgg   866
Thr Leu Glu Cys Thr Gly Val Glu Ser Ser Ile Ala Ala Ala Ile Trp
270                 275                 280                 285
 
gcg tct aaa ttc ggt ggt aaa gtt ttc gtt atc ggt gtt ggt aaa aac   914
Ala Ser Lys Phe Gly Gly Lys Val Phe Val Ile Gly Val Gly Lys Asn
                290                 295                 300
 
gaa atc tct atc ccg ttc atg cgt gcg tct gtt cgt gaa gtt gac atc   962
Glu Ile Ser Ile Pro Phe Met Arg Ala Ser Val Arg Glu Val Asp Ile
            305                 310                 315
 
cag ctc cag tac cgt tac tct aac act tgg ccg cgt gct atc cgt ctg   1010
Gln Leu Gln Tyr Arg Tyr Ser Asn Thr Trp Pro Arg Ala Ile Arg Leu
        320                 325                 330
 
atc gaa tct ggt gtt att gac ctg tct aaa ttc gtt acc cac cgt ttc   1058
Ile Glu Ser Gly Val Ile Asp Leu Ser Lys Phe Val Thr His Arg Phe
    335                 340                 345
 
cca ctc gaa gac gcg gtt aag gct ttc gaa acc tct gcg gac ccg aaa   1106
Pro Leu Glu Asp Ala Val Lys Ala Phe Glu Thr Ser Ala Asp Pro Lys
350                 355                 360                 365
 
tct ggc gct atc aaa gtt atg atc cag tct ctg gac gaattccgat        1152
Ser Gly Ala Ile Lys Val Met Ile Gln Ser Leu Asp
                370                 375
 
g                                                                 1153

<210> 108
<211> 377
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in E. coli

<400> 108
Met Ser Pro Ser Ala Val Asp Asp Ala Pro Lys Ala Thr Gly Ala Ala
 1               5                  10                  15      
Ile Ser Val Lys Pro Asn Ile Gly Val Phe Thr Asn Pro Lys His Asp
            20                  25                  30          
Leu Trp Ile Ser Glu Ala Glu Pro Ser Ala Asp Ala Val Lys Ser Gly
        35                  40                  45              
Ala Asp Leu Lys Pro Gly Glu Val Thr Ile Ala Val Arg Ser Thr Gly
    50                  55                  60                  
Ile Cys Gly Ser Asp Val His Phe Trp His Ala Gly Cys Ile Gly Pro
65                  70                  75                  80  
Met Ile Val Glu Gly Asp His Ile Leu Gly His Glu Ser Ala Gly Glu
                85                  90                  95      
Val Ile Ala Val His Pro Thr Val Ser Ser Leu Gln Ile Gly Asp Arg
            100                 105                 110         
Val Ala Ile Glu Pro Asn Ile Ile Cys Asn Ala Cys Glu Pro Cys Leu
        115                 120                 125             
Thr Gly Arg Tyr Asn Gly Cys Glu Lys Val Glu Phe Leu Ser Thr Pro
    130                 135                 140                 
Pro Val Pro Gly Leu Leu Arg Arg Tyr Val Asn His Pro Ala Val Trp
145                 150                 155                 160 
Cys His Lys Ile Gly Asn Met Ser Trp Glu Asn Gly Ala Leu Leu Glu
                165                 170                 175     
Pro Leu Ser Val Ala Leu Ala Gly Met Gln Arg Ala Lys Val Gln Leu
            180                 185                 190         
Gly Asp Pro Val Leu Val Cys Gly Ala Gly Pro Ile Gly Leu Val Ser
        195                 200                 205             
Met Leu Cys Ala Ala Ala Ala Gly Ala Cys Pro Leu Val Ile Thr Asp
    210                 215                 220                 
Ile Ser Glu Ser Arg Leu Ala Phe Ala Lys Glu Ile Cys Pro Arg Val
225                 230                 235                 240 
Thr Thr His Arg Ile Glu Ile Gly Lys Ser Ala Glu Glu Thr Ala Lys
                245                 250                 255     
Ser Ile Val Ser Ser Phe Gly Gly Val Glu Pro Ala Val Thr Leu Glu
            260                 265                 270         
Cys Thr Gly Val Glu Ser Ser Ile Ala Ala Ala Ile Trp Ala Ser Lys
        275                 280                 285             
Phe Gly Gly Lys Val Phe Val Ile Gly Val Gly Lys Asn Glu Ile Ser
    290                 295                 300                 
Ile Pro Phe Met Arg Ala Ser Val Arg Glu Val Asp Ile Gln Leu Gln
305                 310                 315                 320 
Tyr Arg Tyr Ser Asn Thr Trp Pro Arg Ala Ile Arg Leu Ile Glu Ser
                325                 330                 335     
Gly Val Ile Asp Leu Ser Lys Phe Val Thr His Arg Phe Pro Leu Glu
            340                 345                 350         
Asp Ala Val Lys Ala Phe Glu Thr Ser Ala Asp Pro Lys Ser Gly Ala
        355                 360                 365             
Ile Lys Val Met Ile Gln Ser Leu Asp
    370                 375         


<210> 109
<211> 1159
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in E. coli

<220> 
<221> CDS            
<222> (15)...(1145)

<400> 109
gaatactcca tatg atg tct ccg tct gct gtt gac gac gcg cca aag gct   50
                Met Ser Pro Ser Ala Val Asp Asp Ala Pro Lys Ala
                 1               5                   10
 
acc ggt gct gca atc tct gtt aaa ccg aac atc ggc gtt ttc acc aac   98
Thr Gly Ala Ala Ile Ser Val Lys Pro Asn Ile Gly Val Phe Thr Asn
         15                  20                  25
 
ccg aaa cac gac ctg tgg atc tct gaa gct gag cca tct gcg gac gct   146
Pro Lys His Asp Leu Trp Ile Ser Glu Ala Glu Pro Ser Ala Asp Ala
     30                  35                  40
 
gtt aaa tct ggt gcg gac ctg aaa ccg ggt gaa gtt acc atc gcg gtt   194
Val Lys Ser Gly Ala Asp Leu Lys Pro Gly Glu Val Thr Ile Ala Val
 45                  50                  55                  60
 
cgt tct acc ggt att tgc ggt tct gat gtt cac ttt tgg cac gcg ggt   242
Arg Ser Thr Gly Ile Cys Gly Ser Asp Val His Phe Trp His Ala Gly
                 65                  70                  75
 
tgt atc ggt ccg atg atc gtt gaa ggc gac cac atc ctg ggt cac gaa   290
Cys Ile Gly Pro Met Ile Val Glu Gly Asp His Ile Leu Gly His Glu
             80                  85                  90
 
tct gct ggt gaa gtt atc gct gtt cac ccg acc gtt agc tct ctc cag   338
Ser Ala Gly Glu Val Ile Ala Val His Pro Thr Val Ser Ser Leu Gln
         95                 100                 105
 
atc ggt gac cgt gtt gcg atc gaa ccg aac atc atc tgc aac gct tgc   386
Ile Gly Asp Arg Val Ala Ile Glu Pro Asn Ile Ile Cys Asn Ala Cys
    110                 115                 120
 
gaa cca tgc ctg acc ggt cgt tat aac ggc tgc gaa aaa gtt gaa ttt   434
Glu Pro Cys Leu Thr Gly Arg Tyr Asn Gly Cys Glu Lys Val Glu Phe
125                 130                 135                 140
 
ctg tct acc cca cct gtt ccg ggc ctc ctg cgt cgt tac gtt aat cac   482
Leu Ser Thr Pro Pro Val Pro Gly Leu Leu Arg Arg Tyr Val Asn His
                145                 150                 155
 
ccg gcg gtt tgg tgc cac aaa atc ggt aac atg tct tgg gaa aat ggt   530
Pro Ala Val Trp Cys His Lys Ile Gly Asn Met Ser Trp Glu Asn Gly
            160                 165                 170
 
gct ctg ctc gaa ccg ctg tct gtt gct ctg gct ggt atg caa cgt gcg   578
Ala Leu Leu Glu Pro Leu Ser Val Ala Leu Ala Gly Met Gln Arg Ala
        175                 180                 185
 
aaa gtt cag ctg ggc gac ccg gtt ctg gtt tgc ggt gct ggc cca atc   626
Lys Val Gln Leu Gly Asp Pro Val Leu Val Cys Gly Ala Gly Pro Ile
    190                 195                 200
 
ggt ctg gtt tcg atg ctg tgt gct gct gct gcg ggt gcg tgt cca ctg   674
Gly Leu Val Ser Met Leu Cys Ala Ala Ala Ala Gly Ala Cys Pro Leu
205                 210                 215                 220
 
gtt atc act gac atc tct gaa tct cgt ctc gcg ttt gcg aaa gaa atc   722
Val Ile Thr Asp Ile Ser Glu Ser Arg Leu Ala Phe Ala Lys Glu Ile
                225                 230                 235
 
tgt cca cgt gtg act acc cac cgt atc gaa atc ggt aaa tct gct gag   770
Cys Pro Arg Val Thr Thr His Arg Ile Glu Ile Gly Lys Ser Ala Glu
            240                 245                 250
 
gaa acc gcg aaa tct atc gtt agc tct ttc ggt ggc gtt gaa cca gct   818
Glu Thr Ala Lys Ser Ile Val Ser Ser Phe Gly Gly Val Glu Pro Ala
        255                 260                 265
 
gtt acc ctc gaa tgt acc ggt gtt gaa tct tct atc gcg gct gct att   866
Val Thr Leu Glu Cys Thr Gly Val Glu Ser Ser Ile Ala Ala Ala Ile
    270                 275                 280
 
tgg gcg tct aaa ttc ggt ggt aaa gtt ttc gtt atc ggt gtt ggt aaa   914
Trp Ala Ser Lys Phe Gly Gly Lys Val Phe Val Ile Gly Val Gly Lys
285                 290                 295                 300
 
aac gaa atc tct atc ccg ttc atg cgt gcg tct gtt cgt gaa gtt gac   962
Asn Glu Ile Ser Ile Pro Phe Met Arg Ala Ser Val Arg Glu Val Asp
                305                 310                 315
 
atc cag ctc cag tac cgt tac tct aac act tgg ccg cgt gct atc cgt   1010
Ile Gln Leu Gln Tyr Arg Tyr Ser Asn Thr Trp Pro Arg Ala Ile Arg
            320                 325                 330
 
ctg atc gaa tct ggt gtt att gac ctg tct aaa ttc gtt acc cac cgt   1058
Leu Ile Glu Ser Gly Val Ile Asp Leu Ser Lys Phe Val Thr His Arg
        335                 340                 345
 
ttc cca ctc gaa gac gcg gtt aag gct ttc gaa acc tct gcg gac ccg   1106
Phe Pro Leu Glu Asp Ala Val Lys Ala Phe Glu Thr Ser Ala Asp Pro
    350                 355                 360
 
aaa tct ggc gct atc aaa gtt atg atc cag tct ctg gac actagtcgat    1155
Lys Ser Gly Ala Ile Lys Val Met Ile Gln Ser Leu Asp
365                 370                 375
 
gcct                                                              1159

<210> 110
<211> 377
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in E. coli

<400> 110
Met Ser Pro Ser Ala Val Asp Asp Ala Pro Lys Ala Thr Gly Ala Ala
 1               5                  10                  15      
Ile Ser Val Lys Pro Asn Ile Gly Val Phe Thr Asn Pro Lys His Asp
            20                  25                  30          
Leu Trp Ile Ser Glu Ala Glu Pro Ser Ala Asp Ala Val Lys Ser Gly
        35                  40                  45              
Ala Asp Leu Lys Pro Gly Glu Val Thr Ile Ala Val Arg Ser Thr Gly
    50                  55                  60                  
Ile Cys Gly Ser Asp Val His Phe Trp His Ala Gly Cys Ile Gly Pro
65                  70                  75                  80  
Met Ile Val Glu Gly Asp His Ile Leu Gly His Glu Ser Ala Gly Glu
                85                  90                  95      
Val Ile Ala Val His Pro Thr Val Ser Ser Leu Gln Ile Gly Asp Arg
            100                 105                 110         
Val Ala Ile Glu Pro Asn Ile Ile Cys Asn Ala Cys Glu Pro Cys Leu
        115                 120                 125             
Thr Gly Arg Tyr Asn Gly Cys Glu Lys Val Glu Phe Leu Ser Thr Pro
    130                 135                 140                 
Pro Val Pro Gly Leu Leu Arg Arg Tyr Val Asn His Pro Ala Val Trp
145                 150                 155                 160 
Cys His Lys Ile Gly Asn Met Ser Trp Glu Asn Gly Ala Leu Leu Glu
                165                 170                 175     
Pro Leu Ser Val Ala Leu Ala Gly Met Gln Arg Ala Lys Val Gln Leu
            180                 185                 190         
Gly Asp Pro Val Leu Val Cys Gly Ala Gly Pro Ile Gly Leu Val Ser
        195                 200                 205             
Met Leu Cys Ala Ala Ala Ala Gly Ala Cys Pro Leu Val Ile Thr Asp
    210                 215                 220                 
Ile Ser Glu Ser Arg Leu Ala Phe Ala Lys Glu Ile Cys Pro Arg Val
225                 230                 235                 240 
Thr Thr His Arg Ile Glu Ile Gly Lys Ser Ala Glu Glu Thr Ala Lys
                245                 250                 255     
Ser Ile Val Ser Ser Phe Gly Gly Val Glu Pro Ala Val Thr Leu Glu
            260                 265                 270         
Cys Thr Gly Val Glu Ser Ser Ile Ala Ala Ala Ile Trp Ala Ser Lys
        275                 280                 285             
Phe Gly Gly Lys Val Phe Val Ile Gly Val Gly Lys Asn Glu Ile Ser
    290                 295                 300                 
Ile Pro Phe Met Arg Ala Ser Val Arg Glu Val Asp Ile Gln Leu Gln
305                 310                 315                 320 
Tyr Arg Tyr Ser Asn Thr Trp Pro Arg Ala Ile Arg Leu Ile Glu Ser
                325                 330                 335     
Gly Val Ile Asp Leu Ser Lys Phe Val Thr His Arg Phe Pro Leu Glu
            340                 345                 350         
Asp Ala Val Lys Ala Phe Glu Thr Ser Ala Asp Pro Lys Ser Gly Ala
        355                 360                 365             
Ile Lys Val Met Ile Gln Ser Leu Asp
    370                 375         


<210> 111
<211> 1131
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in P. pastoris

<220> 
<221> CDS            
<222> (1)...(1131)

<400> 111
atg tca cct tct gcc gtg gat gac gct cca aaa gca act ggt gca gct   48
Met Ser Pro Ser Ala Val Asp Asp Ala Pro Lys Ala Thr Gly Ala Ala
 1               5                   10                  15
 
att tct gtt aaa cct aat ata gga gtt ttt act aat cct aaa cat gat   96
Ile Ser Val Lys Pro Asn Ile Gly Val Phe Thr Asn Pro Lys His Asp
             20                  25                  30
 
ttg tgg att tct gag gca gaa cct agt gct gat gca gtt aaa tct gga   144
Leu Trp Ile Ser Glu Ala Glu Pro Ser Ala Asp Ala Val Lys Ser Gly
         35                  40                  45
 
gct gat ttg aag cct ggt gaa gtt act atc gct gtt aga tct act gga   192
Ala Asp Leu Lys Pro Gly Glu Val Thr Ile Ala Val Arg Ser Thr Gly
     50                  55                  60
 
atc tgt gga tct gat gtt cat ttt tgg cac gct gga tgt att gga cca   240
Ile Cys Gly Ser Asp Val His Phe Trp His Ala Gly Cys Ile Gly Pro
 65                  70                  75                  80
 
atg att gtt gaa gga gat cat att ttg gga cat gaa tct gct gga gaa   288
Met Ile Val Glu Gly Asp His Ile Leu Gly His Glu Ser Ala Gly Glu
                 85                  90                  95
 
gtt att gct gtt cat cca act gtt tct tca ttg caa att gga gat aga   336
Val Ile Ala Val His Pro Thr Val Ser Ser Leu Gln Ile Gly Asp Arg
            100                 105                 110
 
gtt gct att gaa cca aat ata att tgt aat gca tgt gaa cct tgt ttg   384
Val Ala Ile Glu Pro Asn Ile Ile Cys Asn Ala Cys Glu Pro Cys Leu
        115                 120                 125
 
act ggt aga tat aat gga tgt gaa aaa gtt gaa ttt ttg tct act cca   432
Thr Gly Arg Tyr Asn Gly Cys Glu Lys Val Glu Phe Leu Ser Thr Pro
    130                 135                 140
 
cca gtt cca gga ttg ttg aga aga tat gtt aat cat cct gct gtt tgg   480
Pro Val Pro Gly Leu Leu Arg Arg Tyr Val Asn His Pro Ala Val Trp
145                 150                 155                 160
 
tgt cat aaa att gga aat atg tct tgg gaa aat gga gct ttg tta gaa   528
Cys His Lys Ile Gly Asn Met Ser Trp Glu Asn Gly Ala Leu Leu Glu
                165                 170                 175
 
cca ttg tct gtt gct ttg gct gga atg caa aga gct aaa gtt caa ttg   576
Pro Leu Ser Val Ala Leu Ala Gly Met Gln Arg Ala Lys Val Gln Leu
            180                 185                 190
 
gga gat cca gtt ttg gtt tgt gga gca gga cca ata gga tta gtt tct   624
Gly Asp Pro Val Leu Val Cys Gly Ala Gly Pro Ile Gly Leu Val Ser
        195                 200                 205
 
atg ttg tgt gca gcc gca gca gga gct tgt cca ttg gtt att act gac   672
Met Leu Cys Ala Ala Ala Ala Gly Ala Cys Pro Leu Val Ile Thr Asp
    210                 215                 220
 
att tct gaa tct aga ttg gct ttt gca aag gaa att tgt cct aga gtt   720
Ile Ser Glu Ser Arg Leu Ala Phe Ala Lys Glu Ile Cys Pro Arg Val
225                 230                 235                 240
 
act act cat aga att gaa att gga aaa tct gct gaa gag act gct aaa   768
Thr Thr His Arg Ile Glu Ile Gly Lys Ser Ala Glu Glu Thr Ala Lys
                245                 250                 255
 
tct att gtt tct tct ttt ggc gga gtg gaa cca gct gtt act tta gaa   816
Ser Ile Val Ser Ser Phe Gly Gly Val Glu Pro Ala Val Thr Leu Glu
            260                 265                 270
 
tgt act gga gtt gaa tct tct att gct gct gct att tgg gct tct aaa   864
Cys Thr Gly Val Glu Ser Ser Ile Ala Ala Ala Ile Trp Ala Ser Lys
        275                 280                 285
 
ttt ggt gga aaa gtt ttt gtt att gga gtt ggt aaa aat gaa att tct   912
Phe Gly Gly Lys Val Phe Val Ile Gly Val Gly Lys Asn Glu Ile Ser
    290                 295                 300
 
att cca ttt atg aga gct tct gtt aga gaa gtt gac att caa ttg caa   960
Ile Pro Phe Met Arg Ala Ser Val Arg Glu Val Asp Ile Gln Leu Gln
305                 310                 315                 320
 
tat aga tat tct aat act tgg cct aga gct att aga ttg att gaa tct   1008
Tyr Arg Tyr Ser Asn Thr Trp Pro Arg Ala Ile Arg Leu Ile Glu Ser
                325                 330                 335
 
gga gtt att gat ttg tct aaa ttt gtt act cat aga ttt cca tta gaa   1056
Gly Val Ile Asp Leu Ser Lys Phe Val Thr His Arg Phe Pro Leu Glu
            340                 345                 350
 
gat gct gtt aag gct ttc gaa act tct gct gat cca aaa tct ggt gct   1104
Asp Ala Val Lys Ala Phe Glu Thr Ser Ala Asp Pro Lys Ser Gly Ala
        355                 360                 365
 
att aaa gtt atg att caa tct tta gat                               1131
Ile Lys Val Met Ile Gln Ser Leu Asp
    370                 375
 

<210> 112
<211> 377
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in P. pastoris

<400> 112
Met Ser Pro Ser Ala Val Asp Asp Ala Pro Lys Ala Thr Gly Ala Ala
 1               5                  10                  15      
Ile Ser Val Lys Pro Asn Ile Gly Val Phe Thr Asn Pro Lys His Asp
            20                  25                  30          
Leu Trp Ile Ser Glu Ala Glu Pro Ser Ala Asp Ala Val Lys Ser Gly
        35                  40                  45              
Ala Asp Leu Lys Pro Gly Glu Val Thr Ile Ala Val Arg Ser Thr Gly
    50                  55                  60                  
Ile Cys Gly Ser Asp Val His Phe Trp His Ala Gly Cys Ile Gly Pro
65                  70                  75                  80  
Met Ile Val Glu Gly Asp His Ile Leu Gly His Glu Ser Ala Gly Glu
                85                  90                  95      
Val Ile Ala Val His Pro Thr Val Ser Ser Leu Gln Ile Gly Asp Arg
            100                 105                 110         
Val Ala Ile Glu Pro Asn Ile Ile Cys Asn Ala Cys Glu Pro Cys Leu
        115                 120                 125             
Thr Gly Arg Tyr Asn Gly Cys Glu Lys Val Glu Phe Leu Ser Thr Pro
    130                 135                 140                 
Pro Val Pro Gly Leu Leu Arg Arg Tyr Val Asn His Pro Ala Val Trp
145                 150                 155                 160 
Cys His Lys Ile Gly Asn Met Ser Trp Glu Asn Gly Ala Leu Leu Glu
                165                 170                 175     
Pro Leu Ser Val Ala Leu Ala Gly Met Gln Arg Ala Lys Val Gln Leu
            180                 185                 190         
Gly Asp Pro Val Leu Val Cys Gly Ala Gly Pro Ile Gly Leu Val Ser
        195                 200                 205             
Met Leu Cys Ala Ala Ala Ala Gly Ala Cys Pro Leu Val Ile Thr Asp
    210                 215                 220                 
Ile Ser Glu Ser Arg Leu Ala Phe Ala Lys Glu Ile Cys Pro Arg Val
225                 230                 235                 240 
Thr Thr His Arg Ile Glu Ile Gly Lys Ser Ala Glu Glu Thr Ala Lys
                245                 250                 255     
Ser Ile Val Ser Ser Phe Gly Gly Val Glu Pro Ala Val Thr Leu Glu
            260                 265                 270         
Cys Thr Gly Val Glu Ser Ser Ile Ala Ala Ala Ile Trp Ala Ser Lys
        275                 280                 285             
Phe Gly Gly Lys Val Phe Val Ile Gly Val Gly Lys Asn Glu Ile Ser
    290                 295                 300                 
Ile Pro Phe Met Arg Ala Ser Val Arg Glu Val Asp Ile Gln Leu Gln
305                 310                 315                 320 
Tyr Arg Tyr Ser Asn Thr Trp Pro Arg Ala Ile Arg Leu Ile Glu Ser
                325                 330                 335     
Gly Val Ile Asp Leu Ser Lys Phe Val Thr His Arg Phe Pro Leu Glu
            340                 345                 350         
Asp Ala Val Lys Ala Phe Glu Thr Ser Ala Asp Pro Lys Ser Gly Ala
        355                 360                 365             
Ile Lys Val Met Ile Gln Ser Leu Asp
    370                 375         


<210> 113
<211> 1153
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in P. pastoris

<220> 
<221> CDS            
<222> (12)...(1142)

<400> 113
tactcaagct t atg tca cct tct gcc gtg gat gac gct cca aaa gca act  50
             Met Ser Pro Ser Ala Val Asp Asp Ala Pro Lys Ala Thr
              1               5                   10
 
ggt gca gct att tct gtt aaa cct aat ata gga gtt ttt act aat cct   98
Gly Ala Ala Ile Ser Val Lys Pro Asn Ile Gly Val Phe Thr Asn Pro
     15                  20                  25
 
aaa cat gat ttg tgg att tct gag gca gaa cct agt gct gat gca gtt   146
Lys His Asp Leu Trp Ile Ser Glu Ala Glu Pro Ser Ala Asp Ala Val
 30                  35                  40                  45
 
aaa tct gga gct gat ttg aag cct ggt gaa gtt act atc gct gtt aga   194
Lys Ser Gly Ala Asp Leu Lys Pro Gly Glu Val Thr Ile Ala Val Arg
                 50                  55                  60
 
tct act gga atc tgt gga tct gat gtt cat ttt tgg cac gct gga tgt   242
Ser Thr Gly Ile Cys Gly Ser Asp Val His Phe Trp His Ala Gly Cys
             65                  70                  75
 
att gga cca atg att gtt gaa gga gat cat att ttg gga cat gaa tct   290
Ile Gly Pro Met Ile Val Glu Gly Asp His Ile Leu Gly His Glu Ser
         80                  85                  90
 
gct gga gaa gtt att gct gtt cat cca act gtt tct tca ttg caa att   338
Ala Gly Glu Val Ile Ala Val His Pro Thr Val Ser Ser Leu Gln Ile
     95                 100                 105
 
gga gat aga gtt gct att gaa cca aat ata att tgt aat gca tgt gaa   386
Gly Asp Arg Val Ala Ile Glu Pro Asn Ile Ile Cys Asn Ala Cys Glu
110                 115                 120                 125
 
cct tgt ttg act ggt aga tat aat gga tgt gaa aaa gtt gaa ttt ttg   434
Pro Cys Leu Thr Gly Arg Tyr Asn Gly Cys Glu Lys Val Glu Phe Leu
                130                 135                 140
 
tct act cca cca gtt cca gga ttg ttg aga aga tat gtt aat cat cct   482
Ser Thr Pro Pro Val Pro Gly Leu Leu Arg Arg Tyr Val Asn His Pro
            145                 150                 155
 
gct gtt tgg tgt cat aaa att gga aat atg tct tgg gaa aat gga gct   530
Ala Val Trp Cys His Lys Ile Gly Asn Met Ser Trp Glu Asn Gly Ala
        160                 165                 170
 
ttg tta gaa cca ttg tct gtt gct ttg gct gga atg caa aga gct aaa   578
Leu Leu Glu Pro Leu Ser Val Ala Leu Ala Gly Met Gln Arg Ala Lys
    175                 180                 185
 
gtt caa ttg gga gat cca gtt ttg gtt tgt gga gca gga cca ata gga   626
Val Gln Leu Gly Asp Pro Val Leu Val Cys Gly Ala Gly Pro Ile Gly
190                 195                 200                 205
 
tta gtt tct atg ttg tgt gca gcc gca gca gga gct tgt cca ttg gtt   674
Leu Val Ser Met Leu Cys Ala Ala Ala Ala Gly Ala Cys Pro Leu Val
                210                 215                 220
 
att act gac att tct gaa tct aga ttg gct ttt gca aag gaa att tgt   722
Ile Thr Asp Ile Ser Glu Ser Arg Leu Ala Phe Ala Lys Glu Ile Cys
            225                 230                 235
 
cct aga gtt act act cat aga att gaa att gga aaa tct gct gaa gag   770
Pro Arg Val Thr Thr His Arg Ile Glu Ile Gly Lys Ser Ala Glu Glu
        240                 245                 250
 
act gct aaa tct att gtt tct tct ttt ggc gga gtg gaa cca gct gtt   818
Thr Ala Lys Ser Ile Val Ser Ser Phe Gly Gly Val Glu Pro Ala Val
    255                 260                 265
 
act tta gaa tgt act gga gtt gaa tct tct att gct gct gct att tgg   866
Thr Leu Glu Cys Thr Gly Val Glu Ser Ser Ile Ala Ala Ala Ile Trp
270                 275                 280                 285
 
gct tct aaa ttt ggt gga aaa gtt ttt gtt att gga gtt ggt aaa aat   914
Ala Ser Lys Phe Gly Gly Lys Val Phe Val Ile Gly Val Gly Lys Asn
                290                 295                 300
 
gaa att tct att cca ttt atg aga gct tct gtt aga gaa gtt gac att   962
Glu Ile Ser Ile Pro Phe Met Arg Ala Ser Val Arg Glu Val Asp Ile
            305                 310                 315
 
caa ttg caa tat aga tat tct aat act tgg cct aga gct att aga ttg   1010
Gln Leu Gln Tyr Arg Tyr Ser Asn Thr Trp Pro Arg Ala Ile Arg Leu
        320                 325                 330
 
att gaa tct gga gtt att gat ttg tct aaa ttt gtt act cat aga ttt   1058
Ile Glu Ser Gly Val Ile Asp Leu Ser Lys Phe Val Thr His Arg Phe
    335                 340                 345
 
cca tta gaa gat gct gtt aag gct ttc gaa act tct gct gat cca aaa   1106
Pro Leu Glu Asp Ala Val Lys Ala Phe Glu Thr Ser Ala Asp Pro Lys
350                 355                 360                 365
 
tct ggt gct att aaa gtt atg att caa tct tta gat gaattccgat        1152
Ser Gly Ala Ile Lys Val Met Ile Gln Ser Leu Asp
                370                 375
 
g                                                                 1153

<210> 114
<211> 377
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in P. pastoris

<400> 114
Met Ser Pro Ser Ala Val Asp Asp Ala Pro Lys Ala Thr Gly Ala Ala
 1               5                  10                  15      
Ile Ser Val Lys Pro Asn Ile Gly Val Phe Thr Asn Pro Lys His Asp
            20                  25                  30          
Leu Trp Ile Ser Glu Ala Glu Pro Ser Ala Asp Ala Val Lys Ser Gly
        35                  40                  45              
Ala Asp Leu Lys Pro Gly Glu Val Thr Ile Ala Val Arg Ser Thr Gly
    50                  55                  60                  
Ile Cys Gly Ser Asp Val His Phe Trp His Ala Gly Cys Ile Gly Pro
65                  70                  75                  80  
Met Ile Val Glu Gly Asp His Ile Leu Gly His Glu Ser Ala Gly Glu
                85                  90                  95      
Val Ile Ala Val His Pro Thr Val Ser Ser Leu Gln Ile Gly Asp Arg
            100                 105                 110         
Val Ala Ile Glu Pro Asn Ile Ile Cys Asn Ala Cys Glu Pro Cys Leu
        115                 120                 125             
Thr Gly Arg Tyr Asn Gly Cys Glu Lys Val Glu Phe Leu Ser Thr Pro
    130                 135                 140                 
Pro Val Pro Gly Leu Leu Arg Arg Tyr Val Asn His Pro Ala Val Trp
145                 150                 155                 160 
Cys His Lys Ile Gly Asn Met Ser Trp Glu Asn Gly Ala Leu Leu Glu
                165                 170                 175     
Pro Leu Ser Val Ala Leu Ala Gly Met Gln Arg Ala Lys Val Gln Leu
            180                 185                 190         
Gly Asp Pro Val Leu Val Cys Gly Ala Gly Pro Ile Gly Leu Val Ser
        195                 200                 205             
Met Leu Cys Ala Ala Ala Ala Gly Ala Cys Pro Leu Val Ile Thr Asp
    210                 215                 220                 
Ile Ser Glu Ser Arg Leu Ala Phe Ala Lys Glu Ile Cys Pro Arg Val
225                 230                 235                 240 
Thr Thr His Arg Ile Glu Ile Gly Lys Ser Ala Glu Glu Thr Ala Lys
                245                 250                 255     
Ser Ile Val Ser Ser Phe Gly Gly Val Glu Pro Ala Val Thr Leu Glu
            260                 265                 270         
Cys Thr Gly Val Glu Ser Ser Ile Ala Ala Ala Ile Trp Ala Ser Lys
        275                 280                 285             
Phe Gly Gly Lys Val Phe Val Ile Gly Val Gly Lys Asn Glu Ile Ser
    290                 295                 300                 
Ile Pro Phe Met Arg Ala Ser Val Arg Glu Val Asp Ile Gln Leu Gln
305                 310                 315                 320 
Tyr Arg Tyr Ser Asn Thr Trp Pro Arg Ala Ile Arg Leu Ile Glu Ser
                325                 330                 335     
Gly Val Ile Asp Leu Ser Lys Phe Val Thr His Arg Phe Pro Leu Glu
            340                 345                 350         
Asp Ala Val Lys Ala Phe Glu Thr Ser Ala Asp Pro Lys Ser Gly Ala
        355                 360                 365             
Ile Lys Val Met Ile Gln Ser Leu Asp
    370                 375         


<210> 115
<211> 1159
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in P. pastoris

<220> 
<221> CDS            
<222> (15)...(1145)

<400> 115
gaatactcca tatg atg tca cct tct gcc gtg gat gac gct cca aaa gca   50
                Met Ser Pro Ser Ala Val Asp Asp Ala Pro Lys Ala
                 1               5                   10
 
act ggt gca gct att tct gtt aaa cct aat ata gga gtt ttt act aat   98
Thr Gly Ala Ala Ile Ser Val Lys Pro Asn Ile Gly Val Phe Thr Asn
         15                  20                  25
 
cct aaa cat gat ttg tgg att tct gag gca gaa cct agt gct gat gca   146
Pro Lys His Asp Leu Trp Ile Ser Glu Ala Glu Pro Ser Ala Asp Ala
     30                  35                  40
 
gtt aaa tct gga gct gat ttg aag cct ggt gaa gtt act atc gct gtt   194
Val Lys Ser Gly Ala Asp Leu Lys Pro Gly Glu Val Thr Ile Ala Val
 45                  50                  55                  60
 
aga tct act gga atc tgt gga tct gat gtt cat ttt tgg cac gct gga   242
Arg Ser Thr Gly Ile Cys Gly Ser Asp Val His Phe Trp His Ala Gly
                 65                  70                  75
 
tgt att gga cca atg att gtt gaa gga gat cat att ttg gga cat gaa   290
Cys Ile Gly Pro Met Ile Val Glu Gly Asp His Ile Leu Gly His Glu
             80                  85                  90
 
tct gct gga gaa gtt att gct gtt cat cca act gtt tct tca ttg caa   338
Ser Ala Gly Glu Val Ile Ala Val His Pro Thr Val Ser Ser Leu Gln
         95                 100                 105
 
att gga gat aga gtt gct att gaa cca aat ata att tgt aat gca tgt   386
Ile Gly Asp Arg Val Ala Ile Glu Pro Asn Ile Ile Cys Asn Ala Cys
    110                 115                 120
 
gaa cct tgt ttg act ggt aga tat aat gga tgt gaa aaa gtt gaa ttt   434
Glu Pro Cys Leu Thr Gly Arg Tyr Asn Gly Cys Glu Lys Val Glu Phe
125                 130                 135                 140
 
ttg tct act cca cca gtt cca gga ttg ttg aga aga tat gtt aat cat   482
Leu Ser Thr Pro Pro Val Pro Gly Leu Leu Arg Arg Tyr Val Asn His
                145                 150                 155
 
cct gct gtt tgg tgt cat aaa att gga aat atg tct tgg gaa aat gga   530
Pro Ala Val Trp Cys His Lys Ile Gly Asn Met Ser Trp Glu Asn Gly
            160                 165                 170
 
gct ttg tta gaa cca ttg tct gtt gct ttg gct gga atg caa aga gct   578
Ala Leu Leu Glu Pro Leu Ser Val Ala Leu Ala Gly Met Gln Arg Ala
        175                 180                 185
 
aaa gtt caa ttg gga gat cca gtt ttg gtt tgt gga gca gga cca ata   626
Lys Val Gln Leu Gly Asp Pro Val Leu Val Cys Gly Ala Gly Pro Ile
    190                 195                 200
 
gga tta gtt tct atg ttg tgt gca gcc gca gca gga gct tgt cca ttg   674
Gly Leu Val Ser Met Leu Cys Ala Ala Ala Ala Gly Ala Cys Pro Leu
205                 210                 215                 220
 
gtt att act gac att tct gaa tct aga ttg gct ttt gca aag gaa att   722
Val Ile Thr Asp Ile Ser Glu Ser Arg Leu Ala Phe Ala Lys Glu Ile
                225                 230                 235
 
tgt cct aga gtt act act cat aga att gaa att gga aaa tct gct gaa   770
Cys Pro Arg Val Thr Thr His Arg Ile Glu Ile Gly Lys Ser Ala Glu
            240                 245                 250
 
gag act gct aaa tct att gtt tct tct ttt ggc gga gtg gaa cca gct   818
Glu Thr Ala Lys Ser Ile Val Ser Ser Phe Gly Gly Val Glu Pro Ala
        255                 260                 265
 
gtt act tta gaa tgt act gga gtt gaa tct tct att gct gct gct att   866
Val Thr Leu Glu Cys Thr Gly Val Glu Ser Ser Ile Ala Ala Ala Ile
    270                 275                 280
 
tgg gct tct aaa ttt ggt gga aaa gtt ttt gtt att gga gtt ggt aaa   914
Trp Ala Ser Lys Phe Gly Gly Lys Val Phe Val Ile Gly Val Gly Lys
285                 290                 295                 300
 
aat gaa att tct att cca ttt atg aga gct tct gtt aga gaa gtt gac   962
Asn Glu Ile Ser Ile Pro Phe Met Arg Ala Ser Val Arg Glu Val Asp
                305                 310                 315
 
att caa ttg caa tat aga tat tct aat act tgg cct aga gct att aga   1010
Ile Gln Leu Gln Tyr Arg Tyr Ser Asn Thr Trp Pro Arg Ala Ile Arg
            320                 325                 330
 
ttg att gaa tct gga gtt att gat ttg tct aaa ttt gtt act cat aga   1058
Leu Ile Glu Ser Gly Val Ile Asp Leu Ser Lys Phe Val Thr His Arg
        335                 340                 345
 
ttt cca tta gaa gat gct gtt aag gct ttc gaa act tct gct gat cca   1106
Phe Pro Leu Glu Asp Ala Val Lys Ala Phe Glu Thr Ser Ala Asp Pro
    350                 355                 360
 
aaa tct ggt gct att aaa gtt atg att caa tct tta gat actagtcgat    1155
Lys Ser Gly Ala Ile Lys Val Met Ile Gln Ser Leu Asp
365                 370                 375
 
gcct                                                              1159

<210> 116
<211> 377
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in P. pastoris

<400> 116
Met Ser Pro Ser Ala Val Asp Asp Ala Pro Lys Ala Thr Gly Ala Ala
 1               5                  10                  15      
Ile Ser Val Lys Pro Asn Ile Gly Val Phe Thr Asn Pro Lys His Asp
            20                  25                  30          
Leu Trp Ile Ser Glu Ala Glu Pro Ser Ala Asp Ala Val Lys Ser Gly
        35                  40                  45              
Ala Asp Leu Lys Pro Gly Glu Val Thr Ile Ala Val Arg Ser Thr Gly
    50                  55                  60                  
Ile Cys Gly Ser Asp Val His Phe Trp His Ala Gly Cys Ile Gly Pro
65                  70                  75                  80  
Met Ile Val Glu Gly Asp His Ile Leu Gly His Glu Ser Ala Gly Glu
                85                  90                  95      
Val Ile Ala Val His Pro Thr Val Ser Ser Leu Gln Ile Gly Asp Arg
            100                 105                 110         
Val Ala Ile Glu Pro Asn Ile Ile Cys Asn Ala Cys Glu Pro Cys Leu
        115                 120                 125             
Thr Gly Arg Tyr Asn Gly Cys Glu Lys Val Glu Phe Leu Ser Thr Pro
    130                 135                 140                 
Pro Val Pro Gly Leu Leu Arg Arg Tyr Val Asn His Pro Ala Val Trp
145                 150                 155                 160 
Cys His Lys Ile Gly Asn Met Ser Trp Glu Asn Gly Ala Leu Leu Glu
                165                 170                 175     
Pro Leu Ser Val Ala Leu Ala Gly Met Gln Arg Ala Lys Val Gln Leu
            180                 185                 190         
Gly Asp Pro Val Leu Val Cys Gly Ala Gly Pro Ile Gly Leu Val Ser
        195                 200                 205             
Met Leu Cys Ala Ala Ala Ala Gly Ala Cys Pro Leu Val Ile Thr Asp
    210                 215                 220                 
Ile Ser Glu Ser Arg Leu Ala Phe Ala Lys Glu Ile Cys Pro Arg Val
225                 230                 235                 240 
Thr Thr His Arg Ile Glu Ile Gly Lys Ser Ala Glu Glu Thr Ala Lys
                245                 250                 255     
Ser Ile Val Ser Ser Phe Gly Gly Val Glu Pro Ala Val Thr Leu Glu
            260                 265                 270         
Cys Thr Gly Val Glu Ser Ser Ile Ala Ala Ala Ile Trp Ala Ser Lys
        275                 280                 285             
Phe Gly Gly Lys Val Phe Val Ile Gly Val Gly Lys Asn Glu Ile Ser
    290                 295                 300                 
Ile Pro Phe Met Arg Ala Ser Val Arg Glu Val Asp Ile Gln Leu Gln
305                 310                 315                 320 
Tyr Arg Tyr Ser Asn Thr Trp Pro Arg Ala Ile Arg Leu Ile Glu Ser
                325                 330                 335     
Gly Val Ile Asp Leu Ser Lys Phe Val Thr His Arg Phe Pro Leu Glu
            340                 345                 350         
Asp Ala Val Lys Ala Phe Glu Thr Ser Ala Asp Pro Lys Ser Gly Ala
        355                 360                 365             
Ile Lys Val Met Ile Gln Ser Leu Asp
    370                 375         


<210> 117
<211> 1131
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in K. lactis

<220> 
<221> CDS            
<222> (1)...(1131)

<400> 117
atg tct cct tct gct gtt gat gat gct cca aaa gct act ggt gct gct   48
Met Ser Pro Ser Ala Val Asp Asp Ala Pro Lys Ala Thr Gly Ala Ala
 1               5                   10                  15
 
att tct gtt aaa cca aat att gga gtt ttc act aat cca aaa cat gat   96
Ile Ser Val Lys Pro Asn Ile Gly Val Phe Thr Asn Pro Lys His Asp
             20                  25                  30
 
ttg tgg att tct gaa gct gaa cca tct gct gat gct gtt aaa tca ggt   144
Leu Trp Ile Ser Glu Ala Glu Pro Ser Ala Asp Ala Val Lys Ser Gly
         35                  40                  45
 
gca gat tta aaa cca ggt gaa gtt act att gct gtt aga tct act gga   192
Ala Asp Leu Lys Pro Gly Glu Val Thr Ile Ala Val Arg Ser Thr Gly
     50                  55                  60
 
att tgt ggt tct gat gtt cac ttc tgg cat gct ggt tgt att ggt cca   240
Ile Cys Gly Ser Asp Val His Phe Trp His Ala Gly Cys Ile Gly Pro
 65                  70                  75                  80
 
atg att gtt gaa ggt gat cat att ttg ggt cat gaa tct gct gga gaa   288
Met Ile Val Glu Gly Asp His Ile Leu Gly His Glu Ser Ala Gly Glu
                 85                  90                  95
 
gtg atc gcc gtg cat cca act gtt tct tca ttg caa att ggt gat aga   336
Val Ile Ala Val His Pro Thr Val Ser Ser Leu Gln Ile Gly Asp Arg
            100                 105                 110
 
gtt gct att gaa cca aat att att tgt aat gct tgt gaa cca tgt ttg   384
Val Ala Ile Glu Pro Asn Ile Ile Cys Asn Ala Cys Glu Pro Cys Leu
        115                 120                 125
 
act ggt aga tat aat ggt tgt gaa aaa gtt gag ttc ttg tct act cca   432
Thr Gly Arg Tyr Asn Gly Cys Glu Lys Val Glu Phe Leu Ser Thr Pro
    130                 135                 140
 
cca gtt cca ggt ttg ttg agg agg tat gtt aat cat cca gct gtc tgg   480
Pro Val Pro Gly Leu Leu Arg Arg Tyr Val Asn His Pro Ala Val Trp
145                 150                 155                 160
 
tgt cat aaa att ggt aat atg tct tgg gaa aat ggt gct ttg ttg gaa   528
Cys His Lys Ile Gly Asn Met Ser Trp Glu Asn Gly Ala Leu Leu Glu
                165                 170                 175
 
cca ttg tct gtt gct ttg gct ggt atg caa aga gct aaa gtt caa ttg   576
Pro Leu Ser Val Ala Leu Ala Gly Met Gln Arg Ala Lys Val Gln Leu
            180                 185                 190
 
ggt gat cca gtt ttg gtt tgt ggt gca ggt cca att ggt ttg gtt tct   624
Gly Asp Pro Val Leu Val Cys Gly Ala Gly Pro Ile Gly Leu Val Ser
        195                 200                 205
 
atg ttg tgt gca gcc gca gca ggt gcg tgt ccg ctt gtt att act gat   672
Met Leu Cys Ala Ala Ala Ala Gly Ala Cys Pro Leu Val Ile Thr Asp
    210                 215                 220
 
ata tct gaa tct agg ttg gct ttc gct aaa gaa att tgt cca agg gtt   720
Ile Ser Glu Ser Arg Leu Ala Phe Ala Lys Glu Ile Cys Pro Arg Val
225                 230                 235                 240
 
act act cat aga att gaa att ggt aag tct gct gaa gaa act gct aaa   768
Thr Thr His Arg Ile Glu Ile Gly Lys Ser Ala Glu Glu Thr Ala Lys
                245                 250                 255
 
tct att gtt tct tct ttc ggt ggt gtt gaa cca gca gta act tta gaa   816
Ser Ile Val Ser Ser Phe Gly Gly Val Glu Pro Ala Val Thr Leu Glu
            260                 265                 270
 
tgt act ggt gtt gag tct tct att gct gct gcc atc tgg gct tct aaa   864
Cys Thr Gly Val Glu Ser Ser Ile Ala Ala Ala Ile Trp Ala Ser Lys
        275                 280                 285
 
ttc gga gga aaa gtt ttc gtt att ggt gtt ggc aaa aat gaa att tct   912
Phe Gly Gly Lys Val Phe Val Ile Gly Val Gly Lys Asn Glu Ile Ser
    290                 295                 300
 
att cca ttc atg aga gct tct gtt aga gaa gtt gat ata cag ttg caa   960
Ile Pro Phe Met Arg Ala Ser Val Arg Glu Val Asp Ile Gln Leu Gln
305                 310                 315                 320
 
tat aga tat tct aat act tgg cca cgt gct att aga ttg att gaa tct   1008
Tyr Arg Tyr Ser Asn Thr Trp Pro Arg Ala Ile Arg Leu Ile Glu Ser
                325                 330                 335
 
ggt gtt att gat ttg tct aag ttc gtc act cat aga ttt cca ttg gaa   1056
Gly Val Ile Asp Leu Ser Lys Phe Val Thr His Arg Phe Pro Leu Glu
            340                 345                 350
 
gat gct gtg aag gct ttt gaa act tct gcc gat cca aaa tct gga gca   1104
Asp Ala Val Lys Ala Phe Glu Thr Ser Ala Asp Pro Lys Ser Gly Ala
        355                 360                 365
 
att aaa gtt atg atc caa tct tta gat                               1131
Ile Lys Val Met Ile Gln Ser Leu Asp
    370                 375
 

<210> 118
<211> 377
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in K. lactis

<400> 118
Met Ser Pro Ser Ala Val Asp Asp Ala Pro Lys Ala Thr Gly Ala Ala
 1               5                  10                  15      
Ile Ser Val Lys Pro Asn Ile Gly Val Phe Thr Asn Pro Lys His Asp
            20                  25                  30          
Leu Trp Ile Ser Glu Ala Glu Pro Ser Ala Asp Ala Val Lys Ser Gly
        35                  40                  45              
Ala Asp Leu Lys Pro Gly Glu Val Thr Ile Ala Val Arg Ser Thr Gly
    50                  55                  60                  
Ile Cys Gly Ser Asp Val His Phe Trp His Ala Gly Cys Ile Gly Pro
65                  70                  75                  80  
Met Ile Val Glu Gly Asp His Ile Leu Gly His Glu Ser Ala Gly Glu
                85                  90                  95      
Val Ile Ala Val His Pro Thr Val Ser Ser Leu Gln Ile Gly Asp Arg
            100                 105                 110         
Val Ala Ile Glu Pro Asn Ile Ile Cys Asn Ala Cys Glu Pro Cys Leu
        115                 120                 125             
Thr Gly Arg Tyr Asn Gly Cys Glu Lys Val Glu Phe Leu Ser Thr Pro
    130                 135                 140                 
Pro Val Pro Gly Leu Leu Arg Arg Tyr Val Asn His Pro Ala Val Trp
145                 150                 155                 160 
Cys His Lys Ile Gly Asn Met Ser Trp Glu Asn Gly Ala Leu Leu Glu
                165                 170                 175     
Pro Leu Ser Val Ala Leu Ala Gly Met Gln Arg Ala Lys Val Gln Leu
            180                 185                 190         
Gly Asp Pro Val Leu Val Cys Gly Ala Gly Pro Ile Gly Leu Val Ser
        195                 200                 205             
Met Leu Cys Ala Ala Ala Ala Gly Ala Cys Pro Leu Val Ile Thr Asp
    210                 215                 220                 
Ile Ser Glu Ser Arg Leu Ala Phe Ala Lys Glu Ile Cys Pro Arg Val
225                 230                 235                 240 
Thr Thr His Arg Ile Glu Ile Gly Lys Ser Ala Glu Glu Thr Ala Lys
                245                 250                 255     
Ser Ile Val Ser Ser Phe Gly Gly Val Glu Pro Ala Val Thr Leu Glu
            260                 265                 270         
Cys Thr Gly Val Glu Ser Ser Ile Ala Ala Ala Ile Trp Ala Ser Lys
        275                 280                 285             
Phe Gly Gly Lys Val Phe Val Ile Gly Val Gly Lys Asn Glu Ile Ser
    290                 295                 300                 
Ile Pro Phe Met Arg Ala Ser Val Arg Glu Val Asp Ile Gln Leu Gln
305                 310                 315                 320 
Tyr Arg Tyr Ser Asn Thr Trp Pro Arg Ala Ile Arg Leu Ile Glu Ser
                325                 330                 335     
Gly Val Ile Asp Leu Ser Lys Phe Val Thr His Arg Phe Pro Leu Glu
            340                 345                 350         
Asp Ala Val Lys Ala Phe Glu Thr Ser Ala Asp Pro Lys Ser Gly Ala
        355                 360                 365             
Ile Lys Val Met Ile Gln Ser Leu Asp
    370                 375         


<210> 119
<211> 1131
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in Z. mobilis

<220> 
<221> CDS            
<222> (1)...(1131)

<400> 119
atg tct ccg tct gcc gtt gat gat gct ccg aaa gcc acc ggc gct gct   48
Met Ser Pro Ser Ala Val Asp Asp Ala Pro Lys Ala Thr Gly Ala Ala
 1               5                   10                  15
 
atc tct gtt aaa ccg aat att ggt gtt ttt acc aac ccg aaa cat gat   96
Ile Ser Val Lys Pro Asn Ile Gly Val Phe Thr Asn Pro Lys His Asp
             20                  25                  30
 
ttg tgg att tct gaa gct gaa ccg agc gcg gac gcc gtt aaa agc ggt   144
Leu Trp Ile Ser Glu Ala Glu Pro Ser Ala Asp Ala Val Lys Ser Gly
         35                  40                  45
 
gct gat ttg aaa ccg ggt gaa gtt acc att gcc gtt cgt tct acc ggt   192
Ala Asp Leu Lys Pro Gly Glu Val Thr Ile Ala Val Arg Ser Thr Gly
     50                  55                  60
 
ata tgt ggt tct gat gtt cat ttt tgg cat gct gga tgt att ggt ccg   240
Ile Cys Gly Ser Asp Val His Phe Trp His Ala Gly Cys Ile Gly Pro
 65                  70                  75                  80
 
atg att gtt gaa ggt gat cat att ttg ggt cat gaa tct gct ggt gaa   288
Met Ile Val Glu Gly Asp His Ile Leu Gly His Glu Ser Ala Gly Glu
                 85                  90                  95
 
gtt atc gcg gtc cat ccg acg gtc tct tct ttg cag att ggt gat cgt   336
Val Ile Ala Val His Pro Thr Val Ser Ser Leu Gln Ile Gly Asp Arg
            100                 105                 110
 
gtt gcc att gaa ccg aat att att tgt aat gct tgt gaa ccg tgt ttg   384
Val Ala Ile Glu Pro Asn Ile Ile Cys Asn Ala Cys Glu Pro Cys Leu
        115                 120                 125
 
acc ggg cgg tat aat ggt tgt gaa aaa gtt gaa ttt ttg tct acc ccg   432
Thr Gly Arg Tyr Asn Gly Cys Glu Lys Val Glu Phe Leu Ser Thr Pro
    130                 135                 140
 
cct gtt ccg ggt ttg ttg cgt cgt tat gtt aat cat ccc gct gtg tgg   480
Pro Val Pro Gly Leu Leu Arg Arg Tyr Val Asn His Pro Ala Val Trp
145                 150                 155                 160
 
tgt cat aaa att ggt aat atg tct tgg gaa aat ggt gct ctt ttg gaa   528
Cys His Lys Ile Gly Asn Met Ser Trp Glu Asn Gly Ala Leu Leu Glu
                165                 170                 175
 
ccg ttg tct gtt gcc ctt gct gga atg cag cgt gct aag gtt cag ttg   576
Pro Leu Ser Val Ala Leu Ala Gly Met Gln Arg Ala Lys Val Gln Leu
            180                 185                 190
 
ggt gat ccg gtt ttg gtt tgt ggt gct ggt cca att ggt ttg gtt tct   624
Gly Asp Pro Val Leu Val Cys Gly Ala Gly Pro Ile Gly Leu Val Ser
        195                 200                 205
 
atg ttg tgt gct gct gcc gct ggg gcg tgt ccg ttg gtt atc acc gat   672
Met Leu Cys Ala Ala Ala Ala Gly Ala Cys Pro Leu Val Ile Thr Asp
    210                 215                 220
 
atc tct gaa tct cgt ttg gcg ttt gcc aaa gaa att tgt ccg aga gtt   720
Ile Ser Glu Ser Arg Leu Ala Phe Ala Lys Glu Ile Cys Pro Arg Val
225                 230                 235                 240
 
acc act cat cgc att gaa att ggt aaa tct gca gag gaa acc gcc aaa   768
Thr Thr His Arg Ile Glu Ile Gly Lys Ser Ala Glu Glu Thr Ala Lys
                245                 250                 255
 
tct att gtt tct tct ttt ggt ggt gtt gaa cct gcg gtc acc ttg gaa   816
Ser Ile Val Ser Ser Phe Gly Gly Val Glu Pro Ala Val Thr Leu Glu
            260                 265                 270
 
tgt acc ggt gtt gaa tct tct att gcc gca gct atc tgg gcc tct aaa   864
Cys Thr Gly Val Glu Ser Ser Ile Ala Ala Ala Ile Trp Ala Ser Lys
        275                 280                 285
 
ttt ggt ggt aaa gtt ttt gtc att ggt gtt ggt aaa aat gaa att tct   912
Phe Gly Gly Lys Val Phe Val Ile Gly Val Gly Lys Asn Glu Ile Ser
    290                 295                 300
 
att ccg ttt atg cgt gca tct gtt cgt gaa gtt gat atc cag ttg cag   960
Ile Pro Phe Met Arg Ala Ser Val Arg Glu Val Asp Ile Gln Leu Gln
305                 310                 315                 320
 
tat cgt tat tct aat acc tgg ccg aga gct atc cgt ttg att gaa tct   1008
Tyr Arg Tyr Ser Asn Thr Trp Pro Arg Ala Ile Arg Leu Ile Glu Ser
                325                 330                 335
 
ggt gtc att gat ttg tct aaa ttt gtt acg cat cgt ttt ccg ctt gaa   1056
Gly Val Ile Asp Leu Ser Lys Phe Val Thr His Arg Phe Pro Leu Glu
            340                 345                 350
 
gat gct gtt aag gcc ttc gaa acc tct gct gat ccg aaa tct ggt gct   1104
Asp Ala Val Lys Ala Phe Glu Thr Ser Ala Asp Pro Lys Ser Gly Ala
        355                 360                 365
 
atc aaa gtc atg att cag tcc ctt gac                               1131
Ile Lys Val Met Ile Gln Ser Leu Asp
    370                 375
 

<210> 120
<211> 377
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in Z. mobilis

<400> 120
Met Ser Pro Ser Ala Val Asp Asp Ala Pro Lys Ala Thr Gly Ala Ala
 1               5                  10                  15      
Ile Ser Val Lys Pro Asn Ile Gly Val Phe Thr Asn Pro Lys His Asp
            20                  25                  30          
Leu Trp Ile Ser Glu Ala Glu Pro Ser Ala Asp Ala Val Lys Ser Gly
        35                  40                  45              
Ala Asp Leu Lys Pro Gly Glu Val Thr Ile Ala Val Arg Ser Thr Gly
    50                  55                  60                  
Ile Cys Gly Ser Asp Val His Phe Trp His Ala Gly Cys Ile Gly Pro
65                  70                  75                  80  
Met Ile Val Glu Gly Asp His Ile Leu Gly His Glu Ser Ala Gly Glu
                85                  90                  95      
Val Ile Ala Val His Pro Thr Val Ser Ser Leu Gln Ile Gly Asp Arg
            100                 105                 110         
Val Ala Ile Glu Pro Asn Ile Ile Cys Asn Ala Cys Glu Pro Cys Leu
        115                 120                 125             
Thr Gly Arg Tyr Asn Gly Cys Glu Lys Val Glu Phe Leu Ser Thr Pro
    130                 135                 140                 
Pro Val Pro Gly Leu Leu Arg Arg Tyr Val Asn His Pro Ala Val Trp
145                 150                 155                 160 
Cys His Lys Ile Gly Asn Met Ser Trp Glu Asn Gly Ala Leu Leu Glu
                165                 170                 175     
Pro Leu Ser Val Ala Leu Ala Gly Met Gln Arg Ala Lys Val Gln Leu
            180                 185                 190         
Gly Asp Pro Val Leu Val Cys Gly Ala Gly Pro Ile Gly Leu Val Ser
        195                 200                 205             
Met Leu Cys Ala Ala Ala Ala Gly Ala Cys Pro Leu Val Ile Thr Asp
    210                 215                 220                 
Ile Ser Glu Ser Arg Leu Ala Phe Ala Lys Glu Ile Cys Pro Arg Val
225                 230                 235                 240 
Thr Thr His Arg Ile Glu Ile Gly Lys Ser Ala Glu Glu Thr Ala Lys
                245                 250                 255     
Ser Ile Val Ser Ser Phe Gly Gly Val Glu Pro Ala Val Thr Leu Glu
            260                 265                 270         
Cys Thr Gly Val Glu Ser Ser Ile Ala Ala Ala Ile Trp Ala Ser Lys
        275                 280                 285             
Phe Gly Gly Lys Val Phe Val Ile Gly Val Gly Lys Asn Glu Ile Ser
    290                 295                 300                 
Ile Pro Phe Met Arg Ala Ser Val Arg Glu Val Asp Ile Gln Leu Gln
305                 310                 315                 320 
Tyr Arg Tyr Ser Asn Thr Trp Pro Arg Ala Ile Arg Leu Ile Glu Ser
                325                 330                 335     
Gly Val Ile Asp Leu Ser Lys Phe Val Thr His Arg Phe Pro Leu Glu
            340                 345                 350         
Asp Ala Val Lys Ala Phe Glu Thr Ser Ala Asp Pro Lys Ser Gly Ala
        355                 360                 365             
Ile Lys Val Met Ile Gln Ser Leu Asp
    370                 375         


<210> 121
<211> 816
<212> DNA
<213> A. monospora

<220> 
<221> CDS            
<222> (1)...(816)

<400> 121
atg act gac tac att cca act ttt aga ttc gat ggc cac tta acc att   48
Met Thr Asp Tyr Ile Pro Thr Phe Arg Phe Asp Gly His Leu Thr Ile
 1               5                   10                  15
 
gtc aca ggt gcc tgt ggt ggt tta gct gaa gct tta atc aag ggt ttg   96
Val Thr Gly Ala Cys Gly Gly Leu Ala Glu Ala Leu Ile Lys Gly Leu
             20                  25                  30
 
ttg gcc tac ggt tct gac att gct ttg ctt gat atc gac caa gaa aag   144
Leu Ala Tyr Gly Ser Asp Ile Ala Leu Leu Asp Ile Asp Gln Glu Lys
         35                  40                  45
 
act gct gcc aaa caa gcc gaa tac cac aaa tac gct act gaa gaa ttg   192
Thr Ala Ala Lys Gln Ala Glu Tyr His Lys Tyr Ala Thr Glu Glu Leu
     50                  55                  60
 
aag ttg aaa gaa gtt cca aag atg ggt tca tat gcc tgt gat att tct   240
Lys Leu Lys Glu Val Pro Lys Met Gly Ser Tyr Ala Cys Asp Ile Ser
 65                  70                  75                  80
 
gat tct gat acc gtt cac aag gtg ttt gct caa gtt gct aag gat ttt   288
Asp Ser Asp Thr Val His Lys Val Phe Ala Gln Val Ala Lys Asp Phe
                 85                  90                  95
 
ggt aag ttg cca ttg cac ttg gtt aac aca gct ggt tac tgt gaa aac   336
Gly Lys Leu Pro Leu His Leu Val Asn Thr Ala Gly Tyr Cys Glu Asn
            100                 105                 110
 
ttc cca tgt gaa gat tac cca gcc aag aac gct gag aag atg gtg aag   384
Phe Pro Cys Glu Asp Tyr Pro Ala Lys Asn Ala Glu Lys Met Val Lys
        115                 120                 125
 
gtt aac ttg ttg ggt tct ttg tat gtt tct caa gcc ttt gct aag cca   432
Val Asn Leu Leu Gly Ser Leu Tyr Val Ser Gln Ala Phe Ala Lys Pro
    130                 135                 140
 
ttg atc aaa gaa ggt atc aag ggt gct tct gtt gtt ttg att ggt tct   480
Leu Ile Lys Glu Gly Ile Lys Gly Ala Ser Val Val Leu Ile Gly Ser
145                 150                 155                 160
 
atg tct ggt gcc att gtc aac gat cct caa aac caa gtt gtc tac aac   528
Met Ser Gly Ala Ile Val Asn Asp Pro Gln Asn Gln Val Val Tyr Asn
                165                 170                 175
 
atg tcc aag gct ggt gtt atc cat ttg gct aag act ttg gct tgt gaa   576
Met Ser Lys Ala Gly Val Ile His Leu Ala Lys Thr Leu Ala Cys Glu
            180                 185                 190
 
tgg gct aag tac aac atc aga gtt aat tct tta aac cca ggt tac atc   624
Trp Ala Lys Tyr Asn Ile Arg Val Asn Ser Leu Asn Pro Gly Tyr Ile
        195                 200                 205
 
tac ggt cct ttg acc aag aat gtt atc aat ggt aac gaa gaa ttg tac   672
Tyr Gly Pro Leu Thr Lys Asn Val Ile Asn Gly Asn Glu Glu Leu Tyr
    210                 215                 220
 
aac aga tgg atc tct ggt atc cca caa caa aga atg tcc gaa cca aag   720
Asn Arg Trp Ile Ser Gly Ile Pro Gln Gln Arg Met Ser Glu Pro Lys
225                 230                 235                 240
 
gaa tac att ggt gct gtt ttg tac ttg ctt tct gaa tct gct gct tca   768
Glu Tyr Ile Gly Ala Val Leu Tyr Leu Leu Ser Glu Ser Ala Ala Ser
                245                 250                 255
 
tac act act ggt gcc agc tta ctg gtt gat ggt ggt ttc act tct tgg   816
Tyr Thr Thr Gly Ala Ser Leu Leu Val Asp Gly Gly Phe Thr Ser Trp
            260                 265                 270
 


<210> 122
<211> 272
<212> PRT
<213> A. monospora

<400> 122
Met Thr Asp Tyr Ile Pro Thr Phe Arg Phe Asp Gly His Leu Thr Ile
 1               5                  10                  15      
Val Thr Gly Ala Cys Gly Gly Leu Ala Glu Ala Leu Ile Lys Gly Leu
            20                  25                  30          
Leu Ala Tyr Gly Ser Asp Ile Ala Leu Leu Asp Ile Asp Gln Glu Lys
        35                  40                  45              
Thr Ala Ala Lys Gln Ala Glu Tyr His Lys Tyr Ala Thr Glu Glu Leu
    50                  55                  60                  
Lys Leu Lys Glu Val Pro Lys Met Gly Ser Tyr Ala Cys Asp Ile Ser
65                  70                  75                  80  
Asp Ser Asp Thr Val His Lys Val Phe Ala Gln Val Ala Lys Asp Phe
                85                  90                  95      
Gly Lys Leu Pro Leu His Leu Val Asn Thr Ala Gly Tyr Cys Glu Asn
            100                 105                 110         
Phe Pro Cys Glu Asp Tyr Pro Ala Lys Asn Ala Glu Lys Met Val Lys
        115                 120                 125             
Val Asn Leu Leu Gly Ser Leu Tyr Val Ser Gln Ala Phe Ala Lys Pro
    130                 135                 140                 
Leu Ile Lys Glu Gly Ile Lys Gly Ala Ser Val Val Leu Ile Gly Ser
145                 150                 155                 160 
Met Ser Gly Ala Ile Val Asn Asp Pro Gln Asn Gln Val Val Tyr Asn
                165                 170                 175     
Met Ser Lys Ala Gly Val Ile His Leu Ala Lys Thr Leu Ala Cys Glu
            180                 185                 190         
Trp Ala Lys Tyr Asn Ile Arg Val Asn Ser Leu Asn Pro Gly Tyr Ile
        195                 200                 205             
Tyr Gly Pro Leu Thr Lys Asn Val Ile Asn Gly Asn Glu Glu Leu Tyr
    210                 215                 220                 
Asn Arg Trp Ile Ser Gly Ile Pro Gln Gln Arg Met Ser Glu Pro Lys
225                 230                 235                 240 
Glu Tyr Ile Gly Ala Val Leu Tyr Leu Leu Ser Glu Ser Ala Ala Ser
                245                 250                 255     
Tyr Thr Thr Gly Ala Ser Leu Leu Val Asp Gly Gly Phe Thr Ser Trp
            260                 265                 270         


<210> 123
<211> 816
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in S. cerevisiae

<220> 
<221> CDS            
<222> (1)...(816)

<400> 123
atg act gat tat att cca act ttt aga ttt gat ggt cat ttg act att   48
Met Thr Asp Tyr Ile Pro Thr Phe Arg Phe Asp Gly His Leu Thr Ile
 1               5                   10                  15
 
gtt aca ggt gca tgt gga ggt ttg gct gaa gct cta att aag ggt ttg   96
Val Thr Gly Ala Cys Gly Gly Leu Ala Glu Ala Leu Ile Lys Gly Leu
             20                  25                  30
 
ttg gct tat ggt tct gat ata gct cta ttg gat ata gat caa gaa aag   144
Leu Ala Tyr Gly Ser Asp Ile Ala Leu Leu Asp Ile Asp Gln Glu Lys
         35                  40                  45
 
act gct gct aaa caa gct gaa tat cat aaa tat gct aca gaa gaa tta   192
Thr Ala Ala Lys Gln Ala Glu Tyr His Lys Tyr Ala Thr Glu Glu Leu
     50                  55                  60
 
aaa tta aaa gaa gtt cca aaa atg ggt tct tat gct tgt gac att tct   240
Lys Leu Lys Glu Val Pro Lys Met Gly Ser Tyr Ala Cys Asp Ile Ser
 65                  70                  75                  80
 
gat tct gat act gtt cat aag gtt ttt gct caa gtt gct aaa gat ttt   288
Asp Ser Asp Thr Val His Lys Val Phe Ala Gln Val Ala Lys Asp Phe
                 85                  90                  95
 
gga aaa ttg cca ttg cat ttg gtt aat acc gct ggt tat tgt gaa aat   336
Gly Lys Leu Pro Leu His Leu Val Asn Thr Ala Gly Tyr Cys Glu Asn
            100                 105                 110
 
ttc cca tgt gaa gat tat cca gct aaa aat gca gag aaa atg gtt aag   384
Phe Pro Cys Glu Asp Tyr Pro Ala Lys Asn Ala Glu Lys Met Val Lys
        115                 120                 125
 
gtt aat ttg ttg ggt tct ttg tat gtt tca caa gca ttt gct aaa cca   432
Val Asn Leu Leu Gly Ser Leu Tyr Val Ser Gln Ala Phe Ala Lys Pro
    130                 135                 140
 
ttg att aaa gaa gga att aaa ggt gct tca gtt gta ctt att ggt tct   480
Leu Ile Lys Glu Gly Ile Lys Gly Ala Ser Val Val Leu Ile Gly Ser
145                 150                 155                 160
 
atg tct gga gct att gtt aat gat cca caa aat caa gtt gtt tat aat   528
Met Ser Gly Ala Ile Val Asn Asp Pro Gln Asn Gln Val Val Tyr Asn
                165                 170                 175
 
atg tct aaa gct ggt gta att cat ttg gca aaa act ctt gct tgt gaa   576
Met Ser Lys Ala Gly Val Ile His Leu Ala Lys Thr Leu Ala Cys Glu
            180                 185                 190
 
tgg gct aaa tat aac att aga gtt aat tct tta aat cca ggt tat att   624
Trp Ala Lys Tyr Asn Ile Arg Val Asn Ser Leu Asn Pro Gly Tyr Ile
        195                 200                 205
 
tat ggt cca ttg act aaa aat gta att aat ggt aat gaa gaa ttg tat   672
Tyr Gly Pro Leu Thr Lys Asn Val Ile Asn Gly Asn Glu Glu Leu Tyr
    210                 215                 220
 
aat aga tgg att tct gga ata cca caa caa aga atg tct gaa cct aaa   720
Asn Arg Trp Ile Ser Gly Ile Pro Gln Gln Arg Met Ser Glu Pro Lys
225                 230                 235                 240
 
gaa tat att ggt gct gtt ttg tat ttg ttg tct gag tct gct gct tct   768
Glu Tyr Ile Gly Ala Val Leu Tyr Leu Leu Ser Glu Ser Ala Ala Ser
                245                 250                 255
 
tat act aca ggt gca tca ttg ttg gtt gat ggt ggt ttt act tct tgg   816
Tyr Thr Thr Gly Ala Ser Leu Leu Val Asp Gly Gly Phe Thr Ser Trp
            260                 265                 270
 


<210> 124
<211> 272
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in S. cerevisiae

<400> 124
Met Thr Asp Tyr Ile Pro Thr Phe Arg Phe Asp Gly His Leu Thr Ile
 1               5                  10                  15      
Val Thr Gly Ala Cys Gly Gly Leu Ala Glu Ala Leu Ile Lys Gly Leu
            20                  25                  30          
Leu Ala Tyr Gly Ser Asp Ile Ala Leu Leu Asp Ile Asp Gln Glu Lys
        35                  40                  45              
Thr Ala Ala Lys Gln Ala Glu Tyr His Lys Tyr Ala Thr Glu Glu Leu
    50                  55                  60                  
Lys Leu Lys Glu Val Pro Lys Met Gly Ser Tyr Ala Cys Asp Ile Ser
65                  70                  75                  80  
Asp Ser Asp Thr Val His Lys Val Phe Ala Gln Val Ala Lys Asp Phe
                85                  90                  95      
Gly Lys Leu Pro Leu His Leu Val Asn Thr Ala Gly Tyr Cys Glu Asn
            100                 105                 110         
Phe Pro Cys Glu Asp Tyr Pro Ala Lys Asn Ala Glu Lys Met Val Lys
        115                 120                 125             
Val Asn Leu Leu Gly Ser Leu Tyr Val Ser Gln Ala Phe Ala Lys Pro
    130                 135                 140                 
Leu Ile Lys Glu Gly Ile Lys Gly Ala Ser Val Val Leu Ile Gly Ser
145                 150                 155                 160 
Met Ser Gly Ala Ile Val Asn Asp Pro Gln Asn Gln Val Val Tyr Asn
                165                 170                 175     
Met Ser Lys Ala Gly Val Ile His Leu Ala Lys Thr Leu Ala Cys Glu
            180                 185                 190         
Trp Ala Lys Tyr Asn Ile Arg Val Asn Ser Leu Asn Pro Gly Tyr Ile
        195                 200                 205             
Tyr Gly Pro Leu Thr Lys Asn Val Ile Asn Gly Asn Glu Glu Leu Tyr
    210                 215                 220                 
Asn Arg Trp Ile Ser Gly Ile Pro Gln Gln Arg Met Ser Glu Pro Lys
225                 230                 235                 240 
Glu Tyr Ile Gly Ala Val Leu Tyr Leu Leu Ser Glu Ser Ala Ala Ser
                245                 250                 255     
Tyr Thr Thr Gly Ala Ser Leu Leu Val Asp Gly Gly Phe Thr Ser Trp
            260                 265                 270         


<210> 125
<211> 838
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in S. cerevisiae

<220> 
<221> CDS            
<222> (12)...(827)

<400> 125
tactcaagct t atg act gat tat att cca act ttt aga ttt gat ggt cat  50
             Met Thr Asp Tyr Ile Pro Thr Phe Arg Phe Asp Gly His
              1               5                   10
 
ttg act att gtt aca ggt gca tgt gga ggt ttg gct gaa gct cta att   98
Leu Thr Ile Val Thr Gly Ala Cys Gly Gly Leu Ala Glu Ala Leu Ile
     15                  20                  25
 
aag ggt ttg ttg gct tat ggt tct gat ata gct cta ttg gat ata gat   146
Lys Gly Leu Leu Ala Tyr Gly Ser Asp Ile Ala Leu Leu Asp Ile Asp
 30                  35                  40                  45
 
caa gaa aag act gct gct aaa caa gct gaa tat cat aaa tat gct aca   194
Gln Glu Lys Thr Ala Ala Lys Gln Ala Glu Tyr His Lys Tyr Ala Thr
                 50                  55                  60
 
gaa gaa tta aaa tta aaa gaa gtt cca aaa atg ggt tct tat gct tgt   242
Glu Glu Leu Lys Leu Lys Glu Val Pro Lys Met Gly Ser Tyr Ala Cys
             65                  70                  75
 
gac att tct gat tct gat act gtt cat aag gtt ttt gct caa gtt gct   290
Asp Ile Ser Asp Ser Asp Thr Val His Lys Val Phe Ala Gln Val Ala
         80                  85                  90
 
aaa gat ttt gga aaa ttg cca ttg cat ttg gtt aat acc gct ggt tat   338
Lys Asp Phe Gly Lys Leu Pro Leu His Leu Val Asn Thr Ala Gly Tyr
     95                 100                 105
 
tgt gaa aat ttc cca tgt gaa gat tat cca gct aaa aat gca gag aaa   386
Cys Glu Asn Phe Pro Cys Glu Asp Tyr Pro Ala Lys Asn Ala Glu Lys
110                 115                 120                 125
 
atg gtt aag gtt aat ttg ttg ggt tct ttg tat gtt tca caa gca ttt   434
Met Val Lys Val Asn Leu Leu Gly Ser Leu Tyr Val Ser Gln Ala Phe
                130                 135                 140
 
gct aaa cca ttg att aaa gaa gga att aaa ggt gct tca gtt gta ctt   482
Ala Lys Pro Leu Ile Lys Glu Gly Ile Lys Gly Ala Ser Val Val Leu
            145                 150                 155
 
att ggt tct atg tct gga gct att gtt aat gat cca caa aat caa gtt   530
Ile Gly Ser Met Ser Gly Ala Ile Val Asn Asp Pro Gln Asn Gln Val
        160                 165                 170
 
gtt tat aat atg tct aaa gct ggt gta att cat ttg gca aaa act ctt   578
Val Tyr Asn Met Ser Lys Ala Gly Val Ile His Leu Ala Lys Thr Leu
    175                 180                 185
 
gct tgt gaa tgg gct aaa tat aac att aga gtt aat tct tta aat cca   626
Ala Cys Glu Trp Ala Lys Tyr Asn Ile Arg Val Asn Ser Leu Asn Pro
190                 195                 200                 205
 
ggt tat att tat ggt cca ttg act aaa aat gta att aat ggt aat gaa   674
Gly Tyr Ile Tyr Gly Pro Leu Thr Lys Asn Val Ile Asn Gly Asn Glu
                210                 215                 220
 
gaa ttg tat aat aga tgg att tct gga ata cca caa caa aga atg tct   722
Glu Leu Tyr Asn Arg Trp Ile Ser Gly Ile Pro Gln Gln Arg Met Ser
            225                 230                 235
 
gaa cct aaa gaa tat att ggt gct gtt ttg tat ttg ttg tct gag tct   770
Glu Pro Lys Glu Tyr Ile Gly Ala Val Leu Tyr Leu Leu Ser Glu Ser
        240                 245                 250
 
gct gct tct tat act aca ggt gca tca ttg ttg gtt gat ggt ggt ttt   818
Ala Ala Ser Tyr Thr Thr Gly Ala Ser Leu Leu Val Asp Gly Gly Phe
    255                 260                 265
 
act tct tgg gaattccgat g                                          838
Thr Ser Trp
270
 

<210> 126
<211> 272
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in S. cerevisiae

<400> 126
Met Thr Asp Tyr Ile Pro Thr Phe Arg Phe Asp Gly His Leu Thr Ile
 1               5                  10                  15      
Val Thr Gly Ala Cys Gly Gly Leu Ala Glu Ala Leu Ile Lys Gly Leu
            20                  25                  30          
Leu Ala Tyr Gly Ser Asp Ile Ala Leu Leu Asp Ile Asp Gln Glu Lys
        35                  40                  45              
Thr Ala Ala Lys Gln Ala Glu Tyr His Lys Tyr Ala Thr Glu Glu Leu
    50                  55                  60                  
Lys Leu Lys Glu Val Pro Lys Met Gly Ser Tyr Ala Cys Asp Ile Ser
65                  70                  75                  80  
Asp Ser Asp Thr Val His Lys Val Phe Ala Gln Val Ala Lys Asp Phe
                85                  90                  95      
Gly Lys Leu Pro Leu His Leu Val Asn Thr Ala Gly Tyr Cys Glu Asn
            100                 105                 110         
Phe Pro Cys Glu Asp Tyr Pro Ala Lys Asn Ala Glu Lys Met Val Lys
        115                 120                 125             
Val Asn Leu Leu Gly Ser Leu Tyr Val Ser Gln Ala Phe Ala Lys Pro
    130                 135                 140                 
Leu Ile Lys Glu Gly Ile Lys Gly Ala Ser Val Val Leu Ile Gly Ser
145                 150                 155                 160 
Met Ser Gly Ala Ile Val Asn Asp Pro Gln Asn Gln Val Val Tyr Asn
                165                 170                 175     
Met Ser Lys Ala Gly Val Ile His Leu Ala Lys Thr Leu Ala Cys Glu
            180                 185                 190         
Trp Ala Lys Tyr Asn Ile Arg Val Asn Ser Leu Asn Pro Gly Tyr Ile
        195                 200                 205             
Tyr Gly Pro Leu Thr Lys Asn Val Ile Asn Gly Asn Glu Glu Leu Tyr
    210                 215                 220                 
Asn Arg Trp Ile Ser Gly Ile Pro Gln Gln Arg Met Ser Glu Pro Lys
225                 230                 235                 240 
Glu Tyr Ile Gly Ala Val Leu Tyr Leu Leu Ser Glu Ser Ala Ala Ser
                245                 250                 255     
Tyr Thr Thr Gly Ala Ser Leu Leu Val Asp Gly Gly Phe Thr Ser Trp
            260                 265                 270         


<210> 127
<211> 844
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in S. cerevisiae

<220> 
<221> CDS            
<222> (15)...(830)

<400> 127
gaatactcca tatg atg act gat tat att cca act ttt aga ttt gat ggt   50
                Met Thr Asp Tyr Ile Pro Thr Phe Arg Phe Asp Gly
                 1               5                   10
 
cat ttg act att gtt aca ggt gca tgt gga ggt ttg gct gaa gct cta   98
His Leu Thr Ile Val Thr Gly Ala Cys Gly Gly Leu Ala Glu Ala Leu
         15                  20                  25
 
att aag ggt ttg ttg gct tat ggt tct gat ata gct cta ttg gat ata   146
Ile Lys Gly Leu Leu Ala Tyr Gly Ser Asp Ile Ala Leu Leu Asp Ile
     30                  35                  40
 
gat caa gaa aag act gct gct aaa caa gct gaa tat cat aaa tat gct   194
Asp Gln Glu Lys Thr Ala Ala Lys Gln Ala Glu Tyr His Lys Tyr Ala
 45                  50                  55                  60
 
aca gaa gaa tta aaa tta aaa gaa gtt cca aaa atg ggt tct tat gct   242
Thr Glu Glu Leu Lys Leu Lys Glu Val Pro Lys Met Gly Ser Tyr Ala
                 65                  70                  75
 
tgt gac att tct gat tct gat act gtt cat aag gtt ttt gct caa gtt   290
Cys Asp Ile Ser Asp Ser Asp Thr Val His Lys Val Phe Ala Gln Val
             80                  85                  90
 
gct aaa gat ttt gga aaa ttg cca ttg cat ttg gtt aat acc gct ggt   338
Ala Lys Asp Phe Gly Lys Leu Pro Leu His Leu Val Asn Thr Ala Gly
         95                 100                 105
 
tat tgt gaa aat ttc cca tgt gaa gat tat cca gct aaa aat gca gag   386
Tyr Cys Glu Asn Phe Pro Cys Glu Asp Tyr Pro Ala Lys Asn Ala Glu
    110                 115                 120
 
aaa atg gtt aag gtt aat ttg ttg ggt tct ttg tat gtt tca caa gca   434
Lys Met Val Lys Val Asn Leu Leu Gly Ser Leu Tyr Val Ser Gln Ala
125                 130                 135                 140
 
ttt gct aaa cca ttg att aaa gaa gga att aaa ggt gct tca gtt gta   482
Phe Ala Lys Pro Leu Ile Lys Glu Gly Ile Lys Gly Ala Ser Val Val
                145                 150                 155
 
ctt att ggt tct atg tct gga gct att gtt aat gat cca caa aat caa   530
Leu Ile Gly Ser Met Ser Gly Ala Ile Val Asn Asp Pro Gln Asn Gln
            160                 165                 170
 
gtt gtt tat aat atg tct aaa gct ggt gta att cat ttg gca aaa act   578
Val Val Tyr Asn Met Ser Lys Ala Gly Val Ile His Leu Ala Lys Thr
        175                 180                 185
 
ctt gct tgt gaa tgg gct aaa tat aac att aga gtt aat tct tta aat   626
Leu Ala Cys Glu Trp Ala Lys Tyr Asn Ile Arg Val Asn Ser Leu Asn
    190                 195                 200
 
cca ggt tat att tat ggt cca ttg act aaa aat gta att aat ggt aat   674
Pro Gly Tyr Ile Tyr Gly Pro Leu Thr Lys Asn Val Ile Asn Gly Asn
205                 210                 215                 220
 
gaa gaa ttg tat aat aga tgg att tct gga ata cca caa caa aga atg   722
Glu Glu Leu Tyr Asn Arg Trp Ile Ser Gly Ile Pro Gln Gln Arg Met
                225                 230                 235
 
tct gaa cct aaa gaa tat att ggt gct gtt ttg tat ttg ttg tct gag   770
Ser Glu Pro Lys Glu Tyr Ile Gly Ala Val Leu Tyr Leu Leu Ser Glu
            240                 245                 250
 
tct gct gct tct tat act aca ggt gca tca ttg ttg gtt gat ggt ggt   818
Ser Ala Ala Ser Tyr Thr Thr Gly Ala Ser Leu Leu Val Asp Gly Gly
        255                 260                 265
 
ttt act tct tgg actagtcgat gcct                                   844
Phe Thr Ser Trp
    270
 

<210> 128
<211> 272
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in S. cerevisiae

<400> 128
Met Thr Asp Tyr Ile Pro Thr Phe Arg Phe Asp Gly His Leu Thr Ile
 1               5                  10                  15      
Val Thr Gly Ala Cys Gly Gly Leu Ala Glu Ala Leu Ile Lys Gly Leu
            20                  25                  30          
Leu Ala Tyr Gly Ser Asp Ile Ala Leu Leu Asp Ile Asp Gln Glu Lys
        35                  40                  45              
Thr Ala Ala Lys Gln Ala Glu Tyr His Lys Tyr Ala Thr Glu Glu Leu
    50                  55                  60                  
Lys Leu Lys Glu Val Pro Lys Met Gly Ser Tyr Ala Cys Asp Ile Ser
65                  70                  75                  80  
Asp Ser Asp Thr Val His Lys Val Phe Ala Gln Val Ala Lys Asp Phe
                85                  90                  95      
Gly Lys Leu Pro Leu His Leu Val Asn Thr Ala Gly Tyr Cys Glu Asn
            100                 105                 110         
Phe Pro Cys Glu Asp Tyr Pro Ala Lys Asn Ala Glu Lys Met Val Lys
        115                 120                 125             
Val Asn Leu Leu Gly Ser Leu Tyr Val Ser Gln Ala Phe Ala Lys Pro
    130                 135                 140                 
Leu Ile Lys Glu Gly Ile Lys Gly Ala Ser Val Val Leu Ile Gly Ser
145                 150                 155                 160 
Met Ser Gly Ala Ile Val Asn Asp Pro Gln Asn Gln Val Val Tyr Asn
                165                 170                 175     
Met Ser Lys Ala Gly Val Ile His Leu Ala Lys Thr Leu Ala Cys Glu
            180                 185                 190         
Trp Ala Lys Tyr Asn Ile Arg Val Asn Ser Leu Asn Pro Gly Tyr Ile
        195                 200                 205             
Tyr Gly Pro Leu Thr Lys Asn Val Ile Asn Gly Asn Glu Glu Leu Tyr
    210                 215                 220                 
Asn Arg Trp Ile Ser Gly Ile Pro Gln Gln Arg Met Ser Glu Pro Lys
225                 230                 235                 240 
Glu Tyr Ile Gly Ala Val Leu Tyr Leu Leu Ser Glu Ser Ala Ala Ser
                245                 250                 255     
Tyr Thr Thr Gly Ala Ser Leu Leu Val Asp Gly Gly Phe Thr Ser Trp
            260                 265                 270         


<210> 129
<211> 816
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in E. coli

<220> 
<221> CDS            
<222> (1)...(816)

<400> 129
atg act gat tat att cca act ttt aga ttt gat ggt cat ttg act att   48
Met Thr Asp Tyr Ile Pro Thr Phe Arg Phe Asp Gly His Leu Thr Ile
 1               5                   10                  15
 
gtt aca ggt gca tgt gga ggt ttg gct gaa gct cta att aag ggt ttg   96
Val Thr Gly Ala Cys Gly Gly Leu Ala Glu Ala Leu Ile Lys Gly Leu
             20                  25                  30
 
ttg gct tat ggt tct gat ata gct cta ttg gat ata gat caa gaa aag   144
Leu Ala Tyr Gly Ser Asp Ile Ala Leu Leu Asp Ile Asp Gln Glu Lys
         35                  40                  45
 
act gct gct aaa caa gct gaa tat cat aaa tat gct aca gaa gaa tta   192
Thr Ala Ala Lys Gln Ala Glu Tyr His Lys Tyr Ala Thr Glu Glu Leu
     50                  55                  60
 
aaa tta aaa gaa gtt cca aaa atg ggt tct tat gct tgt gac att tct   240
Lys Leu Lys Glu Val Pro Lys Met Gly Ser Tyr Ala Cys Asp Ile Ser
 65                  70                  75                  80
 
gat tct gat act gtt cat aag gtt ttt gct caa gtt gct aaa gat ttt   288
Asp Ser Asp Thr Val His Lys Val Phe Ala Gln Val Ala Lys Asp Phe
                 85                  90                  95
 
gga aaa ttg cca ttg cat ttg gtt aat acc gct ggt tat tgt gaa aat   336
Gly Lys Leu Pro Leu His Leu Val Asn Thr Ala Gly Tyr Cys Glu Asn
            100                 105                 110
 
ttc cca tgt gaa gat tat cca gct aaa aat gca gag aaa atg gtt aag   384
Phe Pro Cys Glu Asp Tyr Pro Ala Lys Asn Ala Glu Lys Met Val Lys
        115                 120                 125
 
gtt aat ttg ttg ggt tct ttg tat gtt tca caa gca ttt gct aaa cca   432
Val Asn Leu Leu Gly Ser Leu Tyr Val Ser Gln Ala Phe Ala Lys Pro
    130                 135                 140
 
ttg att aaa gaa gga att aaa ggt gct tca gtt gta ctt att ggt tct   480
Leu Ile Lys Glu Gly Ile Lys Gly Ala Ser Val Val Leu Ile Gly Ser
145                 150                 155                 160
 
atg tct gga gct att gtt aat gat cca caa aat caa gtt gtt tat aat   528
Met Ser Gly Ala Ile Val Asn Asp Pro Gln Asn Gln Val Val Tyr Asn
                165                 170                 175
 
atg tct aaa gct ggt gta att cat ttg gca aaa act ctt gct tgt gaa   576
Met Ser Lys Ala Gly Val Ile His Leu Ala Lys Thr Leu Ala Cys Glu
            180                 185                 190
 
tgg gct aaa tat aac att aga gtt aat tct tta aat cca ggt tat att   624
Trp Ala Lys Tyr Asn Ile Arg Val Asn Ser Leu Asn Pro Gly Tyr Ile
        195                 200                 205
 
tat ggt cca ttg act aaa aat gta att aat ggt aat gaa gaa ttg tat   672
Tyr Gly Pro Leu Thr Lys Asn Val Ile Asn Gly Asn Glu Glu Leu Tyr
    210                 215                 220
 
aat aga tgg att tct gga ata cca caa caa aga atg tct gaa cct aaa   720
Asn Arg Trp Ile Ser Gly Ile Pro Gln Gln Arg Met Ser Glu Pro Lys
225                 230                 235                 240
 
gaa tat att ggt gct gtt ttg tat ttg ttg tct gag tct gct gct tct   768
Glu Tyr Ile Gly Ala Val Leu Tyr Leu Leu Ser Glu Ser Ala Ala Ser
                245                 250                 255
 
tat act aca ggt gca tca ttg ttg gtt gat ggt ggt ttt act tct tgg   816
Tyr Thr Thr Gly Ala Ser Leu Leu Val Asp Gly Gly Phe Thr Ser Trp
            260                 265                 270
 


<210> 130
<211> 272
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in E. coli

<400> 130
Met Thr Asp Tyr Ile Pro Thr Phe Arg Phe Asp Gly His Leu Thr Ile
 1               5                  10                  15      
Val Thr Gly Ala Cys Gly Gly Leu Ala Glu Ala Leu Ile Lys Gly Leu
            20                  25                  30          
Leu Ala Tyr Gly Ser Asp Ile Ala Leu Leu Asp Ile Asp Gln Glu Lys
        35                  40                  45              
Thr Ala Ala Lys Gln Ala Glu Tyr His Lys Tyr Ala Thr Glu Glu Leu
    50                  55                  60                  
Lys Leu Lys Glu Val Pro Lys Met Gly Ser Tyr Ala Cys Asp Ile Ser
65                  70                  75                  80  
Asp Ser Asp Thr Val His Lys Val Phe Ala Gln Val Ala Lys Asp Phe
                85                  90                  95      
Gly Lys Leu Pro Leu His Leu Val Asn Thr Ala Gly Tyr Cys Glu Asn
            100                 105                 110         
Phe Pro Cys Glu Asp Tyr Pro Ala Lys Asn Ala Glu Lys Met Val Lys
        115                 120                 125             
Val Asn Leu Leu Gly Ser Leu Tyr Val Ser Gln Ala Phe Ala Lys Pro
    130                 135                 140                 
Leu Ile Lys Glu Gly Ile Lys Gly Ala Ser Val Val Leu Ile Gly Ser
145                 150                 155                 160 
Met Ser Gly Ala Ile Val Asn Asp Pro Gln Asn Gln Val Val Tyr Asn
                165                 170                 175     
Met Ser Lys Ala Gly Val Ile His Leu Ala Lys Thr Leu Ala Cys Glu
            180                 185                 190         
Trp Ala Lys Tyr Asn Ile Arg Val Asn Ser Leu Asn Pro Gly Tyr Ile
        195                 200                 205             
Tyr Gly Pro Leu Thr Lys Asn Val Ile Asn Gly Asn Glu Glu Leu Tyr
    210                 215                 220                 
Asn Arg Trp Ile Ser Gly Ile Pro Gln Gln Arg Met Ser Glu Pro Lys
225                 230                 235                 240 
Glu Tyr Ile Gly Ala Val Leu Tyr Leu Leu Ser Glu Ser Ala Ala Ser
                245                 250                 255     
Tyr Thr Thr Gly Ala Ser Leu Leu Val Asp Gly Gly Phe Thr Ser Trp
            260                 265                 270         


<210> 131
<211> 838
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in E. coli

<220> 
<221> CDS            
<222> (12)...(827)

<400> 131
tactcaagct t atg act gat tat att cca act ttt aga ttt gat ggt cat  50
             Met Thr Asp Tyr Ile Pro Thr Phe Arg Phe Asp Gly His
              1               5                   10
 
ttg act att gtt aca ggt gca tgt gga ggt ttg gct gaa gct cta att   98
Leu Thr Ile Val Thr Gly Ala Cys Gly Gly Leu Ala Glu Ala Leu Ile
     15                  20                  25
 
aag ggt ttg ttg gct tat ggt tct gat ata gct cta ttg gat ata gat   146
Lys Gly Leu Leu Ala Tyr Gly Ser Asp Ile Ala Leu Leu Asp Ile Asp
 30                  35                  40                  45
 
caa gaa aag act gct gct aaa caa gct gaa tat cat aaa tat gct aca   194
Gln Glu Lys Thr Ala Ala Lys Gln Ala Glu Tyr His Lys Tyr Ala Thr
                 50                  55                  60
 
gaa gaa tta aaa tta aaa gaa gtt cca aaa atg ggt tct tat gct tgt   242
Glu Glu Leu Lys Leu Lys Glu Val Pro Lys Met Gly Ser Tyr Ala Cys
             65                  70                  75
 
gac att tct gat tct gat act gtt cat aag gtt ttt gct caa gtt gct   290
Asp Ile Ser Asp Ser Asp Thr Val His Lys Val Phe Ala Gln Val Ala
         80                  85                  90
 
aaa gat ttt gga aaa ttg cca ttg cat ttg gtt aat acc gct ggt tat   338
Lys Asp Phe Gly Lys Leu Pro Leu His Leu Val Asn Thr Ala Gly Tyr
     95                 100                 105
 
tgt gaa aat ttc cca tgt gaa gat tat cca gct aaa aat gca gag aaa   386
Cys Glu Asn Phe Pro Cys Glu Asp Tyr Pro Ala Lys Asn Ala Glu Lys
110                 115                 120                 125
 
atg gtt aag gtt aat ttg ttg ggt tct ttg tat gtt tca caa gca ttt   434
Met Val Lys Val Asn Leu Leu Gly Ser Leu Tyr Val Ser Gln Ala Phe
                130                 135                 140
 
gct aaa cca ttg att aaa gaa gga att aaa ggt gct tca gtt gta ctt   482
Ala Lys Pro Leu Ile Lys Glu Gly Ile Lys Gly Ala Ser Val Val Leu
            145                 150                 155
 
att ggt tct atg tct gga gct att gtt aat gat cca caa aat caa gtt   530
Ile Gly Ser Met Ser Gly Ala Ile Val Asn Asp Pro Gln Asn Gln Val
        160                 165                 170
 
gtt tat aat atg tct aaa gct ggt gta att cat ttg gca aaa act ctt   578
Val Tyr Asn Met Ser Lys Ala Gly Val Ile His Leu Ala Lys Thr Leu
    175                 180                 185
 
gct tgt gaa tgg gct aaa tat aac att aga gtt aat tct tta aat cca   626
Ala Cys Glu Trp Ala Lys Tyr Asn Ile Arg Val Asn Ser Leu Asn Pro
190                 195                 200                 205
 
ggt tat att tat ggt cca ttg act aaa aat gta att aat ggt aat gaa   674
Gly Tyr Ile Tyr Gly Pro Leu Thr Lys Asn Val Ile Asn Gly Asn Glu
                210                 215                 220
 
gaa ttg tat aat aga tgg att tct gga ata cca caa caa aga atg tct   722
Glu Leu Tyr Asn Arg Trp Ile Ser Gly Ile Pro Gln Gln Arg Met Ser
            225                 230                 235
 
gaa cct aaa gaa tat att ggt gct gtt ttg tat ttg ttg tct gag tct   770
Glu Pro Lys Glu Tyr Ile Gly Ala Val Leu Tyr Leu Leu Ser Glu Ser
        240                 245                 250
 
gct gct tct tat act aca ggt gca tca ttg ttg gtt gat ggt ggt ttt   818
Ala Ala Ser Tyr Thr Thr Gly Ala Ser Leu Leu Val Asp Gly Gly Phe
    255                 260                 265
 
act tct tgg gaattccgat g                                          838
Thr Ser Trp
270
 

<210> 132
<211> 272
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in E. coli

<400> 132
Met Thr Asp Tyr Ile Pro Thr Phe Arg Phe Asp Gly His Leu Thr Ile
 1               5                  10                  15      
Val Thr Gly Ala Cys Gly Gly Leu Ala Glu Ala Leu Ile Lys Gly Leu
            20                  25                  30          
Leu Ala Tyr Gly Ser Asp Ile Ala Leu Leu Asp Ile Asp Gln Glu Lys
        35                  40                  45              
Thr Ala Ala Lys Gln Ala Glu Tyr His Lys Tyr Ala Thr Glu Glu Leu
    50                  55                  60                  
Lys Leu Lys Glu Val Pro Lys Met Gly Ser Tyr Ala Cys Asp Ile Ser
65                  70                  75                  80  
Asp Ser Asp Thr Val His Lys Val Phe Ala Gln Val Ala Lys Asp Phe
                85                  90                  95      
Gly Lys Leu Pro Leu His Leu Val Asn Thr Ala Gly Tyr Cys Glu Asn
            100                 105                 110         
Phe Pro Cys Glu Asp Tyr Pro Ala Lys Asn Ala Glu Lys Met Val Lys
        115                 120                 125             
Val Asn Leu Leu Gly Ser Leu Tyr Val Ser Gln Ala Phe Ala Lys Pro
    130                 135                 140                 
Leu Ile Lys Glu Gly Ile Lys Gly Ala Ser Val Val Leu Ile Gly Ser
145                 150                 155                 160 
Met Ser Gly Ala Ile Val Asn Asp Pro Gln Asn Gln Val Val Tyr Asn
                165                 170                 175     
Met Ser Lys Ala Gly Val Ile His Leu Ala Lys Thr Leu Ala Cys Glu
            180                 185                 190         
Trp Ala Lys Tyr Asn Ile Arg Val Asn Ser Leu Asn Pro Gly Tyr Ile
        195                 200                 205             
Tyr Gly Pro Leu Thr Lys Asn Val Ile Asn Gly Asn Glu Glu Leu Tyr
    210                 215                 220                 
Asn Arg Trp Ile Ser Gly Ile Pro Gln Gln Arg Met Ser Glu Pro Lys
225                 230                 235                 240 
Glu Tyr Ile Gly Ala Val Leu Tyr Leu Leu Ser Glu Ser Ala Ala Ser
                245                 250                 255     
Tyr Thr Thr Gly Ala Ser Leu Leu Val Asp Gly Gly Phe Thr Ser Trp
            260                 265                 270         


<210> 133
<211> 844
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in E. coli

<220> 
<221> CDS            
<222> (15)...(830)

<400> 133
gaatactcca tatg atg act gat tat att cca act ttt aga ttt gat ggt   50
                Met Thr Asp Tyr Ile Pro Thr Phe Arg Phe Asp Gly
                 1               5                   10
 
cat ttg act att gtt aca ggt gca tgt gga ggt ttg gct gaa gct cta   98
His Leu Thr Ile Val Thr Gly Ala Cys Gly Gly Leu Ala Glu Ala Leu
         15                  20                  25
 
att aag ggt ttg ttg gct tat ggt tct gat ata gct cta ttg gat ata   146
Ile Lys Gly Leu Leu Ala Tyr Gly Ser Asp Ile Ala Leu Leu Asp Ile
     30                  35                  40
 
gat caa gaa aag act gct gct aaa caa gct gaa tat cat aaa tat gct   194
Asp Gln Glu Lys Thr Ala Ala Lys Gln Ala Glu Tyr His Lys Tyr Ala
 45                  50                  55                  60
 
aca gaa gaa tta aaa tta aaa gaa gtt cca aaa atg ggt tct tat gct   242
Thr Glu Glu Leu Lys Leu Lys Glu Val Pro Lys Met Gly Ser Tyr Ala
                 65                  70                  75
 
tgt gac att tct gat tct gat act gtt cat aag gtt ttt gct caa gtt   290
Cys Asp Ile Ser Asp Ser Asp Thr Val His Lys Val Phe Ala Gln Val
             80                  85                  90
 
gct aaa gat ttt gga aaa ttg cca ttg cat ttg gtt aat acc gct ggt   338
Ala Lys Asp Phe Gly Lys Leu Pro Leu His Leu Val Asn Thr Ala Gly
         95                 100                 105
 
tat tgt gaa aat ttc cca tgt gaa gat tat cca gct aaa aat gca gag   386
Tyr Cys Glu Asn Phe Pro Cys Glu Asp Tyr Pro Ala Lys Asn Ala Glu
    110                 115                 120
 
aaa atg gtt aag gtt aat ttg ttg ggt tct ttg tat gtt tca caa gca   434
Lys Met Val Lys Val Asn Leu Leu Gly Ser Leu Tyr Val Ser Gln Ala
125                 130                 135                 140
 
ttt gct aaa cca ttg att aaa gaa gga att aaa ggt gct tca gtt gta   482
Phe Ala Lys Pro Leu Ile Lys Glu Gly Ile Lys Gly Ala Ser Val Val
                145                 150                 155
 
ctt att ggt tct atg tct gga gct att gtt aat gat cca caa aat caa   530
Leu Ile Gly Ser Met Ser Gly Ala Ile Val Asn Asp Pro Gln Asn Gln
            160                 165                 170
 
gtt gtt tat aat atg tct aaa gct ggt gta att cat ttg gca aaa act   578
Val Val Tyr Asn Met Ser Lys Ala Gly Val Ile His Leu Ala Lys Thr
        175                 180                 185
 
ctt gct tgt gaa tgg gct aaa tat aac att aga gtt aat tct tta aat   626
Leu Ala Cys Glu Trp Ala Lys Tyr Asn Ile Arg Val Asn Ser Leu Asn
    190                 195                 200
 
cca ggt tat att tat ggt cca ttg act aaa aat gta att aat ggt aat   674
Pro Gly Tyr Ile Tyr Gly Pro Leu Thr Lys Asn Val Ile Asn Gly Asn
205                 210                 215                 220
 
gaa gaa ttg tat aat aga tgg att tct gga ata cca caa caa aga atg   722
Glu Glu Leu Tyr Asn Arg Trp Ile Ser Gly Ile Pro Gln Gln Arg Met
                225                 230                 235
 
tct gaa cct aaa gaa tat att ggt gct gtt ttg tat ttg ttg tct gag   770
Ser Glu Pro Lys Glu Tyr Ile Gly Ala Val Leu Tyr Leu Leu Ser Glu
            240                 245                 250
 
tct gct gct tct tat act aca ggt gca tca ttg ttg gtt gat ggt ggt   818
Ser Ala Ala Ser Tyr Thr Thr Gly Ala Ser Leu Leu Val Asp Gly Gly
        255                 260                 265
 
ttt act tct tgg actagtcgat gcct                                   844
Phe Thr Ser Trp
    270
 

<210> 134
<211> 272
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in E. coli

<400> 134
Met Thr Asp Tyr Ile Pro Thr Phe Arg Phe Asp Gly His Leu Thr Ile
 1               5                  10                  15      
Val Thr Gly Ala Cys Gly Gly Leu Ala Glu Ala Leu Ile Lys Gly Leu
            20                  25                  30          
Leu Ala Tyr Gly Ser Asp Ile Ala Leu Leu Asp Ile Asp Gln Glu Lys
        35                  40                  45              
Thr Ala Ala Lys Gln Ala Glu Tyr His Lys Tyr Ala Thr Glu Glu Leu
    50                  55                  60                  
Lys Leu Lys Glu Val Pro Lys Met Gly Ser Tyr Ala Cys Asp Ile Ser
65                  70                  75                  80  
Asp Ser Asp Thr Val His Lys Val Phe Ala Gln Val Ala Lys Asp Phe
                85                  90                  95      
Gly Lys Leu Pro Leu His Leu Val Asn Thr Ala Gly Tyr Cys Glu Asn
            100                 105                 110         
Phe Pro Cys Glu Asp Tyr Pro Ala Lys Asn Ala Glu Lys Met Val Lys
        115                 120                 125             
Val Asn Leu Leu Gly Ser Leu Tyr Val Ser Gln Ala Phe Ala Lys Pro
    130                 135                 140                 
Leu Ile Lys Glu Gly Ile Lys Gly Ala Ser Val Val Leu Ile Gly Ser
145                 150                 155                 160 
Met Ser Gly Ala Ile Val Asn Asp Pro Gln Asn Gln Val Val Tyr Asn
                165                 170                 175     
Met Ser Lys Ala Gly Val Ile His Leu Ala Lys Thr Leu Ala Cys Glu
            180                 185                 190         
Trp Ala Lys Tyr Asn Ile Arg Val Asn Ser Leu Asn Pro Gly Tyr Ile
        195                 200                 205             
Tyr Gly Pro Leu Thr Lys Asn Val Ile Asn Gly Asn Glu Glu Leu Tyr
    210                 215                 220                 
Asn Arg Trp Ile Ser Gly Ile Pro Gln Gln Arg Met Ser Glu Pro Lys
225                 230                 235                 240 
Glu Tyr Ile Gly Ala Val Leu Tyr Leu Leu Ser Glu Ser Ala Ala Ser
                245                 250                 255     
Tyr Thr Thr Gly Ala Ser Leu Leu Val Asp Gly Gly Phe Thr Ser Trp
            260                 265                 270         


<210> 135
<211> 816
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in P. pastoris

<220> 
<221> CDS            
<222> (1)...(816)

<400> 135
atg act gat tat att cca act ttt agg ttt gat ggt cat ttg act att   48
Met Thr Asp Tyr Ile Pro Thr Phe Arg Phe Asp Gly His Leu Thr Ile
 1               5                   10                  15
 
gtt act gga gct tgt gga gga ttg gct gaa gca ttg att aag gga ttg   96
Val Thr Gly Ala Cys Gly Gly Leu Ala Glu Ala Leu Ile Lys Gly Leu
             20                  25                  30
 
ttg gct tat gga tct gat ata gct ctg ttg gac att gat caa gag aaa   144
Leu Ala Tyr Gly Ser Asp Ile Ala Leu Leu Asp Ile Asp Gln Glu Lys
         35                  40                  45
 
acc gct gct aaa caa gct gaa tat cat aaa tat gct act gaa gaa ttg   192
Thr Ala Ala Lys Gln Ala Glu Tyr His Lys Tyr Ala Thr Glu Glu Leu
     50                  55                  60
 
aag tta aaa gaa gtt cca aaa atg gga tct tat gct tgt gac att tct   240
Lys Leu Lys Glu Val Pro Lys Met Gly Ser Tyr Ala Cys Asp Ile Ser
 65                  70                  75                  80
 
gat tct gat act gtt cat aaa gtt ttc gct caa gtt gct aaa gat ttt   288
Asp Ser Asp Thr Val His Lys Val Phe Ala Gln Val Ala Lys Asp Phe
                 85                  90                  95
 
ggt aaa ttg cca ttg cat ttg gtt aat act gct ggt tat tgt gaa aat   336
Gly Lys Leu Pro Leu His Leu Val Asn Thr Ala Gly Tyr Cys Glu Asn
            100                 105                 110
 
ttt cca tgt gaa gat tat cca gct aaa aat gca gaa aag atg gtt aaa   384
Phe Pro Cys Glu Asp Tyr Pro Ala Lys Asn Ala Glu Lys Met Val Lys
        115                 120                 125
 
gtt aat ttg ttg gga tca ttg tat gtt tct caa gca ttc gct aaa cct   432
Val Asn Leu Leu Gly Ser Leu Tyr Val Ser Gln Ala Phe Ala Lys Pro
    130                 135                 140
 
ttg att aaa gaa gga att aaa gga gct tct gtt gtt ttg att gga tct   480
Leu Ile Lys Glu Gly Ile Lys Gly Ala Ser Val Val Leu Ile Gly Ser
145                 150                 155                 160
 
atg tct gga gct att gtt aat gat cca caa aat caa gtt gtt tat aat   528
Met Ser Gly Ala Ile Val Asn Asp Pro Gln Asn Gln Val Val Tyr Asn
                165                 170                 175
 
atg tct aaa gct gga gtt att cat ttg gca aaa act tta gca tgt gaa   576
Met Ser Lys Ala Gly Val Ile His Leu Ala Lys Thr Leu Ala Cys Glu
            180                 185                 190
 
tgg gct aaa tat aac att aga gtt aat tct tta aat cca gga tat att   624
Trp Ala Lys Tyr Asn Ile Arg Val Asn Ser Leu Asn Pro Gly Tyr Ile
        195                 200                 205
 
tat gga cca ttg act aaa aat gtt att aat gga aat gaa gaa ttg tat   672
Tyr Gly Pro Leu Thr Lys Asn Val Ile Asn Gly Asn Glu Glu Leu Tyr
    210                 215                 220
 
aat aga tgg att tct gga ata cca caa caa aga atg tct gaa cca aaa   720
Asn Arg Trp Ile Ser Gly Ile Pro Gln Gln Arg Met Ser Glu Pro Lys
225                 230                 235                 240
 
gaa tac atc gga gct gtt ttg tat ttg ttg tct gaa tct gct gct tct   768
Glu Tyr Ile Gly Ala Val Leu Tyr Leu Leu Ser Glu Ser Ala Ala Ser
                245                 250                 255
 
tat act act gga gct tca ttg ttg gtt gat gga gga ttt act tct tgg   816
Tyr Thr Thr Gly Ala Ser Leu Leu Val Asp Gly Gly Phe Thr Ser Trp
            260                 265                 270
 


<210> 136
<211> 272
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in P. pastoris

<400> 136
Met Thr Asp Tyr Ile Pro Thr Phe Arg Phe Asp Gly His Leu Thr Ile
 1               5                  10                  15      
Val Thr Gly Ala Cys Gly Gly Leu Ala Glu Ala Leu Ile Lys Gly Leu
            20                  25                  30          
Leu Ala Tyr Gly Ser Asp Ile Ala Leu Leu Asp Ile Asp Gln Glu Lys
        35                  40                  45              
Thr Ala Ala Lys Gln Ala Glu Tyr His Lys Tyr Ala Thr Glu Glu Leu
    50                  55                  60                  
Lys Leu Lys Glu Val Pro Lys Met Gly Ser Tyr Ala Cys Asp Ile Ser
65                  70                  75                  80  
Asp Ser Asp Thr Val His Lys Val Phe Ala Gln Val Ala Lys Asp Phe
                85                  90                  95      
Gly Lys Leu Pro Leu His Leu Val Asn Thr Ala Gly Tyr Cys Glu Asn
            100                 105                 110         
Phe Pro Cys Glu Asp Tyr Pro Ala Lys Asn Ala Glu Lys Met Val Lys
        115                 120                 125             
Val Asn Leu Leu Gly Ser Leu Tyr Val Ser Gln Ala Phe Ala Lys Pro
    130                 135                 140                 
Leu Ile Lys Glu Gly Ile Lys Gly Ala Ser Val Val Leu Ile Gly Ser
145                 150                 155                 160 
Met Ser Gly Ala Ile Val Asn Asp Pro Gln Asn Gln Val Val Tyr Asn
                165                 170                 175     
Met Ser Lys Ala Gly Val Ile His Leu Ala Lys Thr Leu Ala Cys Glu
            180                 185                 190         
Trp Ala Lys Tyr Asn Ile Arg Val Asn Ser Leu Asn Pro Gly Tyr Ile
        195                 200                 205             
Tyr Gly Pro Leu Thr Lys Asn Val Ile Asn Gly Asn Glu Glu Leu Tyr
    210                 215                 220                 
Asn Arg Trp Ile Ser Gly Ile Pro Gln Gln Arg Met Ser Glu Pro Lys
225                 230                 235                 240 
Glu Tyr Ile Gly Ala Val Leu Tyr Leu Leu Ser Glu Ser Ala Ala Ser
                245                 250                 255     
Tyr Thr Thr Gly Ala Ser Leu Leu Val Asp Gly Gly Phe Thr Ser Trp
            260                 265                 270         


<210> 137
<211> 838
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in P. pastoris

<220> 
<221> CDS            
<222> (12)...(827)

<400> 137
tactcaagct t atg act gat tat att cca act ttt agg ttt gat ggt cat  50
             Met Thr Asp Tyr Ile Pro Thr Phe Arg Phe Asp Gly His
              1               5                   10
 
ttg act att gtt act gga gct tgt gga gga ttg gct gaa gca ttg att   98
Leu Thr Ile Val Thr Gly Ala Cys Gly Gly Leu Ala Glu Ala Leu Ile
     15                  20                  25
 
aag gga ttg ttg gct tat gga tct gat ata gct ctg ttg gac att gat   146
Lys Gly Leu Leu Ala Tyr Gly Ser Asp Ile Ala Leu Leu Asp Ile Asp
 30                  35                  40                  45
 
caa gag aaa acc gct gct aaa caa gct gaa tat cat aaa tat gct act   194
Gln Glu Lys Thr Ala Ala Lys Gln Ala Glu Tyr His Lys Tyr Ala Thr
                 50                  55                  60
 
gaa gaa ttg aag tta aaa gaa gtt cca aaa atg gga tct tat gct tgt   242
Glu Glu Leu Lys Leu Lys Glu Val Pro Lys Met Gly Ser Tyr Ala Cys
             65                  70                  75
 
gac att tct gat tct gat act gtt cat aaa gtt ttc gct caa gtt gct   290
Asp Ile Ser Asp Ser Asp Thr Val His Lys Val Phe Ala Gln Val Ala
         80                  85                  90
 
aaa gat ttt ggt aaa ttg cca ttg cat ttg gtt aat act gct ggt tat   338
Lys Asp Phe Gly Lys Leu Pro Leu His Leu Val Asn Thr Ala Gly Tyr
     95                 100                 105
 
tgt gaa aat ttt cca tgt gaa gat tat cca gct aaa aat gca gaa aag   386
Cys Glu Asn Phe Pro Cys Glu Asp Tyr Pro Ala Lys Asn Ala Glu Lys
110                 115                 120                 125
 
atg gtt aaa gtt aat ttg ttg gga tca ttg tat gtt tct caa gca ttc   434
Met Val Lys Val Asn Leu Leu Gly Ser Leu Tyr Val Ser Gln Ala Phe
                130                 135                 140
 
gct aaa cct ttg att aaa gaa gga att aaa gga gct tct gtt gtt ttg   482
Ala Lys Pro Leu Ile Lys Glu Gly Ile Lys Gly Ala Ser Val Val Leu
            145                 150                 155
 
att gga tct atg tct gga gct att gtt aat gat cca caa aat caa gtt   530
Ile Gly Ser Met Ser Gly Ala Ile Val Asn Asp Pro Gln Asn Gln Val
        160                 165                 170
 
gtt tat aat atg tct aaa gct gga gtt att cat ttg gca aaa act tta   578
Val Tyr Asn Met Ser Lys Ala Gly Val Ile His Leu Ala Lys Thr Leu
    175                 180                 185
 
gca tgt gaa tgg gct aaa tat aac att aga gtt aat tct tta aat cca   626
Ala Cys Glu Trp Ala Lys Tyr Asn Ile Arg Val Asn Ser Leu Asn Pro
190                 195                 200                 205
 
gga tat att tat gga cca ttg act aaa aat gtt att aat gga aat gaa   674
Gly Tyr Ile Tyr Gly Pro Leu Thr Lys Asn Val Ile Asn Gly Asn Glu
                210                 215                 220
 
gaa ttg tat aat aga tgg att tct gga ata cca caa caa aga atg tct   722
Glu Leu Tyr Asn Arg Trp Ile Ser Gly Ile Pro Gln Gln Arg Met Ser
            225                 230                 235
 
gaa cca aaa gaa tac atc gga gct gtt ttg tat ttg ttg tct gaa tct   770
Glu Pro Lys Glu Tyr Ile Gly Ala Val Leu Tyr Leu Leu Ser Glu Ser
        240                 245                 250
 
gct gct tct tat act act gga gct tca ttg ttg gtt gat gga gga ttt   818
Ala Ala Ser Tyr Thr Thr Gly Ala Ser Leu Leu Val Asp Gly Gly Phe
    255                 260                 265
 
act tct tgg gaattccgat g                                          838
Thr Ser Trp
270
 

<210> 138
<211> 272
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in P. pastoris

<400> 138
Met Thr Asp Tyr Ile Pro Thr Phe Arg Phe Asp Gly His Leu Thr Ile
 1               5                  10                  15      
Val Thr Gly Ala Cys Gly Gly Leu Ala Glu Ala Leu Ile Lys Gly Leu
            20                  25                  30          
Leu Ala Tyr Gly Ser Asp Ile Ala Leu Leu Asp Ile Asp Gln Glu Lys
        35                  40                  45              
Thr Ala Ala Lys Gln Ala Glu Tyr His Lys Tyr Ala Thr Glu Glu Leu
    50                  55                  60                  
Lys Leu Lys Glu Val Pro Lys Met Gly Ser Tyr Ala Cys Asp Ile Ser
65                  70                  75                  80  
Asp Ser Asp Thr Val His Lys Val Phe Ala Gln Val Ala Lys Asp Phe
                85                  90                  95      
Gly Lys Leu Pro Leu His Leu Val Asn Thr Ala Gly Tyr Cys Glu Asn
            100                 105                 110         
Phe Pro Cys Glu Asp Tyr Pro Ala Lys Asn Ala Glu Lys Met Val Lys
        115                 120                 125             
Val Asn Leu Leu Gly Ser Leu Tyr Val Ser Gln Ala Phe Ala Lys Pro
    130                 135                 140                 
Leu Ile Lys Glu Gly Ile Lys Gly Ala Ser Val Val Leu Ile Gly Ser
145                 150                 155                 160 
Met Ser Gly Ala Ile Val Asn Asp Pro Gln Asn Gln Val Val Tyr Asn
                165                 170                 175     
Met Ser Lys Ala Gly Val Ile His Leu Ala Lys Thr Leu Ala Cys Glu
            180                 185                 190         
Trp Ala Lys Tyr Asn Ile Arg Val Asn Ser Leu Asn Pro Gly Tyr Ile
        195                 200                 205             
Tyr Gly Pro Leu Thr Lys Asn Val Ile Asn Gly Asn Glu Glu Leu Tyr
    210                 215                 220                 
Asn Arg Trp Ile Ser Gly Ile Pro Gln Gln Arg Met Ser Glu Pro Lys
225                 230                 235                 240 
Glu Tyr Ile Gly Ala Val Leu Tyr Leu Leu Ser Glu Ser Ala Ala Ser
                245                 250                 255     
Tyr Thr Thr Gly Ala Ser Leu Leu Val Asp Gly Gly Phe Thr Ser Trp
            260                 265                 270         


<210> 139
<211> 844
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in P. pastoris

<220> 
<221> CDS            
<222> (15)...(830)

<400> 139
gaatactcca tatg atg act gat tat att cca act ttt agg ttt gat ggt   50
                Met Thr Asp Tyr Ile Pro Thr Phe Arg Phe Asp Gly
                 1               5                   10
 
cat ttg act att gtt act gga gct tgt gga gga ttg gct gaa gca ttg   98
His Leu Thr Ile Val Thr Gly Ala Cys Gly Gly Leu Ala Glu Ala Leu
         15                  20                  25
 
att aag gga ttg ttg gct tat gga tct gat ata gct ctg ttg gac att   146
Ile Lys Gly Leu Leu Ala Tyr Gly Ser Asp Ile Ala Leu Leu Asp Ile
     30                  35                  40
 
gat caa gag aaa acc gct gct aaa caa gct gaa tat cat aaa tat gct   194
Asp Gln Glu Lys Thr Ala Ala Lys Gln Ala Glu Tyr His Lys Tyr Ala
 45                  50                  55                  60
 
act gaa gaa ttg aag tta aaa gaa gtt cca aaa atg gga tct tat gct   242
Thr Glu Glu Leu Lys Leu Lys Glu Val Pro Lys Met Gly Ser Tyr Ala
                 65                  70                  75
 
tgt gac att tct gat tct gat act gtt cat aaa gtt ttc gct caa gtt   290
Cys Asp Ile Ser Asp Ser Asp Thr Val His Lys Val Phe Ala Gln Val
             80                  85                  90
 
gct aaa gat ttt ggt aaa ttg cca ttg cat ttg gtt aat act gct ggt   338
Ala Lys Asp Phe Gly Lys Leu Pro Leu His Leu Val Asn Thr Ala Gly
         95                 100                 105
 
tat tgt gaa aat ttt cca tgt gaa gat tat cca gct aaa aat gca gaa   386
Tyr Cys Glu Asn Phe Pro Cys Glu Asp Tyr Pro Ala Lys Asn Ala Glu
    110                 115                 120
 
aag atg gtt aaa gtt aat ttg ttg gga tca ttg tat gtt tct caa gca   434
Lys Met Val Lys Val Asn Leu Leu Gly Ser Leu Tyr Val Ser Gln Ala
125                 130                 135                 140
 
ttc gct aaa cct ttg att aaa gaa gga att aaa gga gct tct gtt gtt   482
Phe Ala Lys Pro Leu Ile Lys Glu Gly Ile Lys Gly Ala Ser Val Val
                145                 150                 155
 
ttg att gga tct atg tct gga gct att gtt aat gat cca caa aat caa   530
Leu Ile Gly Ser Met Ser Gly Ala Ile Val Asn Asp Pro Gln Asn Gln
            160                 165                 170
 
gtt gtt tat aat atg tct aaa gct gga gtt att cat ttg gca aaa act   578
Val Val Tyr Asn Met Ser Lys Ala Gly Val Ile His Leu Ala Lys Thr
        175                 180                 185
 
tta gca tgt gaa tgg gct aaa tat aac att aga gtt aat tct tta aat   626
Leu Ala Cys Glu Trp Ala Lys Tyr Asn Ile Arg Val Asn Ser Leu Asn
    190                 195                 200
 
cca gga tat att tat gga cca ttg act aaa aat gtt att aat gga aat   674
Pro Gly Tyr Ile Tyr Gly Pro Leu Thr Lys Asn Val Ile Asn Gly Asn
205                 210                 215                 220
 
gaa gaa ttg tat aat aga tgg att tct gga ata cca caa caa aga atg   722
Glu Glu Leu Tyr Asn Arg Trp Ile Ser Gly Ile Pro Gln Gln Arg Met
                225                 230                 235
 
tct gaa cca aaa gaa tac atc gga gct gtt ttg tat ttg ttg tct gaa   770
Ser Glu Pro Lys Glu Tyr Ile Gly Ala Val Leu Tyr Leu Leu Ser Glu
            240                 245                 250
 
tct gct gct tct tat act act gga gct tca ttg ttg gtt gat gga gga   818
Ser Ala Ala Ser Tyr Thr Thr Gly Ala Ser Leu Leu Val Asp Gly Gly
        255                 260                 265
 
ttt act tct tgg actagtcgat gcct                                   844
Phe Thr Ser Trp
    270
 

<210> 140
<211> 272
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in P. pastoris

<400> 140
Met Thr Asp Tyr Ile Pro Thr Phe Arg Phe Asp Gly His Leu Thr Ile
 1               5                  10                  15      
Val Thr Gly Ala Cys Gly Gly Leu Ala Glu Ala Leu Ile Lys Gly Leu
            20                  25                  30          
Leu Ala Tyr Gly Ser Asp Ile Ala Leu Leu Asp Ile Asp Gln Glu Lys
        35                  40                  45              
Thr Ala Ala Lys Gln Ala Glu Tyr His Lys Tyr Ala Thr Glu Glu Leu
    50                  55                  60                  
Lys Leu Lys Glu Val Pro Lys Met Gly Ser Tyr Ala Cys Asp Ile Ser
65                  70                  75                  80  
Asp Ser Asp Thr Val His Lys Val Phe Ala Gln Val Ala Lys Asp Phe
                85                  90                  95      
Gly Lys Leu Pro Leu His Leu Val Asn Thr Ala Gly Tyr Cys Glu Asn
            100                 105                 110         
Phe Pro Cys Glu Asp Tyr Pro Ala Lys Asn Ala Glu Lys Met Val Lys
        115                 120                 125             
Val Asn Leu Leu Gly Ser Leu Tyr Val Ser Gln Ala Phe Ala Lys Pro
    130                 135                 140                 
Leu Ile Lys Glu Gly Ile Lys Gly Ala Ser Val Val Leu Ile Gly Ser
145                 150                 155                 160 
Met Ser Gly Ala Ile Val Asn Asp Pro Gln Asn Gln Val Val Tyr Asn
                165                 170                 175     
Met Ser Lys Ala Gly Val Ile His Leu Ala Lys Thr Leu Ala Cys Glu
            180                 185                 190         
Trp Ala Lys Tyr Asn Ile Arg Val Asn Ser Leu Asn Pro Gly Tyr Ile
        195                 200                 205             
Tyr Gly Pro Leu Thr Lys Asn Val Ile Asn Gly Asn Glu Glu Leu Tyr
    210                 215                 220                 
Asn Arg Trp Ile Ser Gly Ile Pro Gln Gln Arg Met Ser Glu Pro Lys
225                 230                 235                 240 
Glu Tyr Ile Gly Ala Val Leu Tyr Leu Leu Ser Glu Ser Ala Ala Ser
                245                 250                 255     
Tyr Thr Thr Gly Ala Ser Leu Leu Val Asp Gly Gly Phe Thr Ser Trp
            260                 265                 270         


<210> 141
<211> 816
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in K. lactis

<220> 
<221> CDS            
<222> (1)...(816)

<400> 141
atg act gat tat att cca act ttc aga ttc gat ggt cat ttg act att   48
Met Thr Asp Tyr Ile Pro Thr Phe Arg Phe Asp Gly His Leu Thr Ile
 1               5                   10                  15
 
gtt act ggt gct tgt ggt ggt ttg gct gag gct tta att aaa ggt ttg   96
Val Thr Gly Ala Cys Gly Gly Leu Ala Glu Ala Leu Ile Lys Gly Leu
             20                  25                  30
 
ttg gct tat ggt tct gac att gct ttg ttg gac att gat caa gaa aag   144
Leu Ala Tyr Gly Ser Asp Ile Ala Leu Leu Asp Ile Asp Gln Glu Lys
         35                  40                  45
 
act gct gct aaa caa gct gaa tat cat aaa tat gct act gaa gaa tta   192
Thr Ala Ala Lys Gln Ala Glu Tyr His Lys Tyr Ala Thr Glu Glu Leu
     50                  55                  60
 
aag tta aag gaa gtt cca aaa atg ggt tct tat gcc tgt gac att tct   240
Lys Leu Lys Glu Val Pro Lys Met Gly Ser Tyr Ala Cys Asp Ile Ser
 65                  70                  75                  80
 
gat tct gat act gtt cat aaa gtt ttc gct caa gtt gct aaa gat ttc   288
Asp Ser Asp Thr Val His Lys Val Phe Ala Gln Val Ala Lys Asp Phe
                 85                  90                  95
 
ggt aag ttg cca ttg cat ttg gtt aat act gct ggt tat tgt gaa aat   336
Gly Lys Leu Pro Leu His Leu Val Asn Thr Ala Gly Tyr Cys Glu Asn
            100                 105                 110
 
ttc cct tgt gaa gat tat cca gct aaa aat gct gag aag atg gtt aaa   384
Phe Pro Cys Glu Asp Tyr Pro Ala Lys Asn Ala Glu Lys Met Val Lys
        115                 120                 125
 
gtt aat ttg ttg ggt agt ttg tat gtt tct cag gct ttc gct aaa cca   432
Val Asn Leu Leu Gly Ser Leu Tyr Val Ser Gln Ala Phe Ala Lys Pro
    130                 135                 140
 
ttg att aaa gaa gga att aaa ggt gct agc gta gtt cta att ggt tct   480
Leu Ile Lys Glu Gly Ile Lys Gly Ala Ser Val Val Leu Ile Gly Ser
145                 150                 155                 160
 
atg tct gga gca att gtt aat gat cca caa aat caa gtt gtt tat aat   528
Met Ser Gly Ala Ile Val Asn Asp Pro Gln Asn Gln Val Val Tyr Asn
                165                 170                 175
 
atg tct aaa gct ggt gtt att cat ttg gct aaa act tta gca tgt gaa   576
Met Ser Lys Ala Gly Val Ile His Leu Ala Lys Thr Leu Ala Cys Glu
            180                 185                 190
 
tgg gct aaa tat aat att aga gtt aat tct tta aat cca ggt tat att   624
Trp Ala Lys Tyr Asn Ile Arg Val Asn Ser Leu Asn Pro Gly Tyr Ile
        195                 200                 205
 
tat ggt cca ttg act aaa aat gtt att aat ggt aat gaa gaa ctc tat   672
Tyr Gly Pro Leu Thr Lys Asn Val Ile Asn Gly Asn Glu Glu Leu Tyr
    210                 215                 220
 
aat aga tgg att tct ggc att cca caa caa aga atg agc gag cct aag   720
Asn Arg Trp Ile Ser Gly Ile Pro Gln Gln Arg Met Ser Glu Pro Lys
225                 230                 235                 240
 
gaa tat att gga gcc gtt ttg tat tta ttg tct gaa tct gcc gca tct   768
Glu Tyr Ile Gly Ala Val Leu Tyr Leu Leu Ser Glu Ser Ala Ala Ser
                245                 250                 255
 
tat act act gga gcg tct tta tta gtt gac gga ggt ttc act tct tgg   816
Tyr Thr Thr Gly Ala Ser Leu Leu Val Asp Gly Gly Phe Thr Ser Trp
            260                 265                 270
 


<210> 142
<211> 272
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in K. lactis

<400> 142
Met Thr Asp Tyr Ile Pro Thr Phe Arg Phe Asp Gly His Leu Thr Ile
 1               5                  10                  15      
Val Thr Gly Ala Cys Gly Gly Leu Ala Glu Ala Leu Ile Lys Gly Leu
            20                  25                  30          
Leu Ala Tyr Gly Ser Asp Ile Ala Leu Leu Asp Ile Asp Gln Glu Lys
        35                  40                  45              
Thr Ala Ala Lys Gln Ala Glu Tyr His Lys Tyr Ala Thr Glu Glu Leu
    50                  55                  60                  
Lys Leu Lys Glu Val Pro Lys Met Gly Ser Tyr Ala Cys Asp Ile Ser
65                  70                  75                  80  
Asp Ser Asp Thr Val His Lys Val Phe Ala Gln Val Ala Lys Asp Phe
                85                  90                  95      
Gly Lys Leu Pro Leu His Leu Val Asn Thr Ala Gly Tyr Cys Glu Asn
            100                 105                 110         
Phe Pro Cys Glu Asp Tyr Pro Ala Lys Asn Ala Glu Lys Met Val Lys
        115                 120                 125             
Val Asn Leu Leu Gly Ser Leu Tyr Val Ser Gln Ala Phe Ala Lys Pro
    130                 135                 140                 
Leu Ile Lys Glu Gly Ile Lys Gly Ala Ser Val Val Leu Ile Gly Ser
145                 150                 155                 160 
Met Ser Gly Ala Ile Val Asn Asp Pro Gln Asn Gln Val Val Tyr Asn
                165                 170                 175     
Met Ser Lys Ala Gly Val Ile His Leu Ala Lys Thr Leu Ala Cys Glu
            180                 185                 190         
Trp Ala Lys Tyr Asn Ile Arg Val Asn Ser Leu Asn Pro Gly Tyr Ile
        195                 200                 205             
Tyr Gly Pro Leu Thr Lys Asn Val Ile Asn Gly Asn Glu Glu Leu Tyr
    210                 215                 220                 
Asn Arg Trp Ile Ser Gly Ile Pro Gln Gln Arg Met Ser Glu Pro Lys
225                 230                 235                 240 
Glu Tyr Ile Gly Ala Val Leu Tyr Leu Leu Ser Glu Ser Ala Ala Ser
                245                 250                 255     
Tyr Thr Thr Gly Ala Ser Leu Leu Val Asp Gly Gly Phe Thr Ser Trp
            260                 265                 270         


<210> 143
<211> 816
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in Z. mobilis

<220> 
<221> CDS            
<222> (1)...(816)

<400> 143
atg acc gat tat att ccg acc ttt cgt ttt gat ggt cat ttg acg att   48
Met Thr Asp Tyr Ile Pro Thr Phe Arg Phe Asp Gly His Leu Thr Ile
 1               5                   10                  15
 
gtt acc ggt gct tgt ggt ggt ttg gcc gaa gct ctt att aaa ggt ttg   96
Val Thr Gly Ala Cys Gly Gly Leu Ala Glu Ala Leu Ile Lys Gly Leu
             20                  25                  30
 
ttg gct tat ggt tct gat atc gct ctt ttg gac att gat cag gag aaa   144
Leu Ala Tyr Gly Ser Asp Ile Ala Leu Leu Asp Ile Asp Gln Glu Lys
         35                  40                  45
 
acc gcc gcc aaa cag gcc gag tat cat aaa tat gcc acc gaa gaa ttg   192
Thr Ala Ala Lys Gln Ala Glu Tyr His Lys Tyr Ala Thr Glu Glu Leu
     50                  55                  60
 
aaa ttg aaa gaa gtt ccg aaa atg ggt tct tat gca tgt gat atc tct   240
Lys Leu Lys Glu Val Pro Lys Met Gly Ser Tyr Ala Cys Asp Ile Ser
 65                  70                  75                  80
 
gat tct gat acc gtt cat aaa gtt ttt gcc cag gtt gcc aaa gat ttt   288
Asp Ser Asp Thr Val His Lys Val Phe Ala Gln Val Ala Lys Asp Phe
                 85                  90                  95
 
ggt aaa ttg ccg ttg cat ttg gtt aat acc gct ggt tat tgt gaa aat   336
Gly Lys Leu Pro Leu His Leu Val Asn Thr Ala Gly Tyr Cys Glu Asn
            100                 105                 110
 
ttt ccg tgt gaa gat tat ccg gct aag aat gcg gaa aag atg gtt aaa   384
Phe Pro Cys Glu Asp Tyr Pro Ala Lys Asn Ala Glu Lys Met Val Lys
        115                 120                 125
 
gtt aat ttg ttg ggt tct ttg tat gtt tct cag gct ttc gct aag ccg   432
Val Asn Leu Leu Gly Ser Leu Tyr Val Ser Gln Ala Phe Ala Lys Pro
    130                 135                 140
 
tta att aaa gaa ggg att aaa ggt gcc tct gtt gtt ttg att ggt tct   480
Leu Ile Lys Glu Gly Ile Lys Gly Ala Ser Val Val Leu Ile Gly Ser
145                 150                 155                 160
 
atg tct ggt gcc att gtt aat gat ccg cag aat cag gtt gtt tat aat   528
Met Ser Gly Ala Ile Val Asn Asp Pro Gln Asn Gln Val Val Tyr Asn
                165                 170                 175
 
atg tct aaa gct ggt gtc att cat ttg gct aag acc ttg gct tgt gaa   576
Met Ser Lys Ala Gly Val Ile His Leu Ala Lys Thr Leu Ala Cys Glu
            180                 185                 190
 
tgg gcc aaa tat aat att cgt gtt aat tct ttg aat ccg ggt tat att   624
Trp Ala Lys Tyr Asn Ile Arg Val Asn Ser Leu Asn Pro Gly Tyr Ile
        195                 200                 205
 
tat ggt ccg ttg acc aaa aat gtc att aat ggt aat gaa gaa ttg tat   672
Tyr Gly Pro Leu Thr Lys Asn Val Ile Asn Gly Asn Glu Glu Leu Tyr
    210                 215                 220
 
aat cgt tgg att tct ggc atc ccg cag cag aga atg tct gaa ccg aaa   720
Asn Arg Trp Ile Ser Gly Ile Pro Gln Gln Arg Met Ser Glu Pro Lys
225                 230                 235                 240
 
gaa tat att ggt gcc gtc ttg tat ttg ttg tct gaa tct gcc gca tct   768
Glu Tyr Ile Gly Ala Val Leu Tyr Leu Leu Ser Glu Ser Ala Ala Ser
                245                 250                 255
 
tat acc acc ggg gcc tct ttg ttg gtt gat ggt ggc ttt acc tct tgg   816
Tyr Thr Thr Gly Ala Ser Leu Leu Val Asp Gly Gly Phe Thr Ser Trp
            260                 265                 270
 


<210> 144
<211> 272
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in Z. mobilis

<400> 144
Met Thr Asp Tyr Ile Pro Thr Phe Arg Phe Asp Gly His Leu Thr Ile
 1               5                  10                  15      
Val Thr Gly Ala Cys Gly Gly Leu Ala Glu Ala Leu Ile Lys Gly Leu
            20                  25                  30          
Leu Ala Tyr Gly Ser Asp Ile Ala Leu Leu Asp Ile Asp Gln Glu Lys
        35                  40                  45              
Thr Ala Ala Lys Gln Ala Glu Tyr His Lys Tyr Ala Thr Glu Glu Leu
    50                  55                  60                  
Lys Leu Lys Glu Val Pro Lys Met Gly Ser Tyr Ala Cys Asp Ile Ser
65                  70                  75                  80  
Asp Ser Asp Thr Val His Lys Val Phe Ala Gln Val Ala Lys Asp Phe
                85                  90                  95      
Gly Lys Leu Pro Leu His Leu Val Asn Thr Ala Gly Tyr Cys Glu Asn
            100                 105                 110         
Phe Pro Cys Glu Asp Tyr Pro Ala Lys Asn Ala Glu Lys Met Val Lys
        115                 120                 125             
Val Asn Leu Leu Gly Ser Leu Tyr Val Ser Gln Ala Phe Ala Lys Pro
    130                 135                 140                 
Leu Ile Lys Glu Gly Ile Lys Gly Ala Ser Val Val Leu Ile Gly Ser
145                 150                 155                 160 
Met Ser Gly Ala Ile Val Asn Asp Pro Gln Asn Gln Val Val Tyr Asn
                165                 170                 175     
Met Ser Lys Ala Gly Val Ile His Leu Ala Lys Thr Leu Ala Cys Glu
            180                 185                 190         
Trp Ala Lys Tyr Asn Ile Arg Val Asn Ser Leu Asn Pro Gly Tyr Ile
        195                 200                 205             
Tyr Gly Pro Leu Thr Lys Asn Val Ile Asn Gly Asn Glu Glu Leu Tyr
    210                 215                 220                 
Asn Arg Trp Ile Ser Gly Ile Pro Gln Gln Arg Met Ser Glu Pro Lys
225                 230                 235                 240 
Glu Tyr Ile Gly Ala Val Leu Tyr Leu Leu Ser Glu Ser Ala Ala Ser
                245                 250                 255     
Tyr Thr Thr Gly Ala Ser Leu Leu Val Asp Gly Gly Phe Thr Ser Trp
            260                 265                 270         


<210> 145
<211> 801
<212> DNA
<213> T. reesei

<220> 
<221> CDS            
<222> (1)...(801)

<400> 145
atg cct cag cct gtc ccc acc gcc aac aga ctc ctt gat ctc ttc agc   48
Met Pro Gln Pro Val Pro Thr Ala Asn Arg Leu Leu Asp Leu Phe Ser
 1               5                   10                  15
 
ttg aag ggc aag gtc gtc gtc gtc acc ggc gct tcc ggc cct cga ggc   96
Leu Lys Gly Lys Val Val Val Val Thr Gly Ala Ser Gly Pro Arg Gly
             20                  25                  30
 
atg gga atc gaa gct gcc cgt ggc tgc gcc gag atg ggc gct gac ctc   144
Met Gly Ile Glu Ala Ala Arg Gly Cys Ala Glu Met Gly Ala Asp Leu
         35                  40                  45
 
gcc atc acc tac tcg tct cgc aag gag ggc gcg gag aag aac gcc gag   192
Ala Ile Thr Tyr Ser Ser Arg Lys Glu Gly Ala Glu Lys Asn Ala Glu
     50                  55                  60
 
gaa ttg acc aag gaa tac ggc gtc aaa gtc aag gtg tac aag gtc aac   240
Glu Leu Thr Lys Glu Tyr Gly Val Lys Val Lys Val Tyr Lys Val Asn
 65                  70                  75                  80
 
cag agc gac tac aac gat gtt gag cgc ttt gtg aac cag gtc gtg tct   288
Gln Ser Asp Tyr Asn Asp Val Glu Arg Phe Val Asn Gln Val Val Ser
                 85                  90                  95
 
gac ttt ggc aag atc gat gcc ttt att gcc aac gcc gga gcc aca gct   336
Asp Phe Gly Lys Ile Asp Ala Phe Ile Ala Asn Ala Gly Ala Thr Ala
            100                 105                 110
 
aat agc gga gtt gtt gac ggc agc gcc agc gat tgg gac cat gtc atc   384
Asn Ser Gly Val Val Asp Gly Ser Ala Ser Asp Trp Asp His Val Ile
        115                 120                 125
 
cag gtc gac ctg agc ggc acc gca tac tgc gca aag gct gtt ggc gcg   432
Gln Val Asp Leu Ser Gly Thr Ala Tyr Cys Ala Lys Ala Val Gly Ala
    130                 135                 140
 
cac ttc aag aag cag ggc cac ggc tcc ctt gtc atc aca gct tca atg   480
His Phe Lys Lys Gln Gly His Gly Ser Leu Val Ile Thr Ala Ser Met
145                 150                 155                 160
 
tcc ggc cac gtc gca aac tat ccc cag gaa cag acc tca tac aac gtc   528
Ser Gly His Val Ala Asn Tyr Pro Gln Glu Gln Thr Ser Tyr Asn Val
                165                 170                 175
 
gcc aag gcc ggt tgc atc cat ctg gcg cgg tct ctg gcc aac gag tgg   576
Ala Lys Ala Gly Cys Ile His Leu Ala Arg Ser Leu Ala Asn Glu Trp
            180                 185                 190
 
cgt gat ttt gcc cgc gtc aac agc att tcg ccc ggt tat atc gat acc   624
Arg Asp Phe Ala Arg Val Asn Ser Ile Ser Pro Gly Tyr Ile Asp Thr
        195                 200                 205
 
ggc ctg tcc gac ttc atc gac gag aag acg caa gag ctg tgg agg agc   672
Gly Leu Ser Asp Phe Ile Asp Glu Lys Thr Gln Glu Leu Trp Arg Ser
    210                 215                 220
 
atg atc ccc atg gga cga aac ggc gat gcc aag gag ctc aag ggc gcg   720
Met Ile Pro Met Gly Arg Asn Gly Asp Ala Lys Glu Leu Lys Gly Ala
225                 230                 235                 240
 
tat gta tat ctg gtc agc gac gct agc tcg tac acg acg gga gcc gat   768
Tyr Val Tyr Leu Val Ser Asp Ala Ser Ser Tyr Thr Thr Gly Ala Asp
                245                 250                 255
 
att gtg att gac gga ggt tac act aca cga taa                       801
Ile Val Ile Asp Gly Gly Tyr Thr Thr Arg  *
            260                 265
 

<210> 146
<211> 266
<212> PRT
<213> T. reesei

<400> 146
Met Pro Gln Pro Val Pro Thr Ala Asn Arg Leu Leu Asp Leu Phe Ser
 1               5                  10                  15      
Leu Lys Gly Lys Val Val Val Val Thr Gly Ala Ser Gly Pro Arg Gly
            20                  25                  30          
Met Gly Ile Glu Ala Ala Arg Gly Cys Ala Glu Met Gly Ala Asp Leu
        35                  40                  45              
Ala Ile Thr Tyr Ser Ser Arg Lys Glu Gly Ala Glu Lys Asn Ala Glu
    50                  55                  60                  
Glu Leu Thr Lys Glu Tyr Gly Val Lys Val Lys Val Tyr Lys Val Asn
65                  70                  75                  80  
Gln Ser Asp Tyr Asn Asp Val Glu Arg Phe Val Asn Gln Val Val Ser
                85                  90                  95      
Asp Phe Gly Lys Ile Asp Ala Phe Ile Ala Asn Ala Gly Ala Thr Ala
            100                 105                 110         
Asn Ser Gly Val Val Asp Gly Ser Ala Ser Asp Trp Asp His Val Ile
        115                 120                 125             
Gln Val Asp Leu Ser Gly Thr Ala Tyr Cys Ala Lys Ala Val Gly Ala
    130                 135                 140                 
His Phe Lys Lys Gln Gly His Gly Ser Leu Val Ile Thr Ala Ser Met
145                 150                 155                 160 
Ser Gly His Val Ala Asn Tyr Pro Gln Glu Gln Thr Ser Tyr Asn Val
                165                 170                 175     
Ala Lys Ala Gly Cys Ile His Leu Ala Arg Ser Leu Ala Asn Glu Trp
            180                 185                 190         
Arg Asp Phe Ala Arg Val Asn Ser Ile Ser Pro Gly Tyr Ile Asp Thr
        195                 200                 205             
Gly Leu Ser Asp Phe Ile Asp Glu Lys Thr Gln Glu Leu Trp Arg Ser
    210                 215                 220                 
Met Ile Pro Met Gly Arg Asn Gly Asp Ala Lys Glu Leu Lys Gly Ala
225                 230                 235                 240 
Tyr Val Tyr Leu Val Ser Asp Ala Ser Ser Tyr Thr Thr Gly Ala Asp
                245                 250                 255     
Ile Val Ile Asp Gly Gly Tyr Thr Thr Arg
            260                 265     


<210> 147
<211> 798
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in S. cerevisiae

<220> 
<221> CDS            
<222> (1)...(798)

<400> 147
atg cca caa cct gtt cca act gct aat aga ttg tta gat ttg ttt tct   48
Met Pro Gln Pro Val Pro Thr Ala Asn Arg Leu Leu Asp Leu Phe Ser
 1               5                   10                  15
 
tta aaa ggt aaa gta gtt gtt gtt act ggt gct tct ggt cct aga ggt   96
Leu Lys Gly Lys Val Val Val Val Thr Gly Ala Ser Gly Pro Arg Gly
             20                  25                  30
 
atg gga att gaa gct gct aga gga tgt gct gaa atg gga gca gat tta   144
Met Gly Ile Glu Ala Ala Arg Gly Cys Ala Glu Met Gly Ala Asp Leu
         35                  40                  45
 
gct att act tat tct tct aga aag gaa gga gct gag aaa aat gct gag   192
Ala Ile Thr Tyr Ser Ser Arg Lys Glu Gly Ala Glu Lys Asn Ala Glu
     50                  55                  60
 
gaa ttg act aaa gaa tat ggt gtt aaa gta aaa gta tat aag gtt aat   240
Glu Leu Thr Lys Glu Tyr Gly Val Lys Val Lys Val Tyr Lys Val Asn
 65                  70                  75                  80
 
caa tct gat tat aat gat gtt gaa aga ttt gta aat caa gtt gtt tca   288
Gln Ser Asp Tyr Asn Asp Val Glu Arg Phe Val Asn Gln Val Val Ser
                 85                  90                  95
 
gat ttc ggt aaa att gat gct ttt att gct aac gct gga gct acc gct   336
Asp Phe Gly Lys Ile Asp Ala Phe Ile Ala Asn Ala Gly Ala Thr Ala
            100                 105                 110
 
aat tct ggt gtt gtt gat ggt tct gct tca gat tgg gat cat gtt ata   384
Asn Ser Gly Val Val Asp Gly Ser Ala Ser Asp Trp Asp His Val Ile
        115                 120                 125
 
caa gtt gat ttg tct gga act gct tat tgt gca aag gct gta ggt gct   432
Gln Val Asp Leu Ser Gly Thr Ala Tyr Cys Ala Lys Ala Val Gly Ala
    130                 135                 140
 
cat ttt aaa aag caa ggt cat ggt tct ttg gtt ata aca gct tct atg   480
His Phe Lys Lys Gln Gly His Gly Ser Leu Val Ile Thr Ala Ser Met
145                 150                 155                 160
 
tct ggt cat gtt gct aat tat cca caa gaa caa act tca tat aat gtt   528
Ser Gly His Val Ala Asn Tyr Pro Gln Glu Gln Thr Ser Tyr Asn Val
                165                 170                 175
 
gca aaa gct ggt tgt att cat ttg gct aga tct ttg gct aat gaa tgg   576
Ala Lys Ala Gly Cys Ile His Leu Ala Arg Ser Leu Ala Asn Glu Trp
            180                 185                 190
 
aga gat ttt gct aga gtt aat tct att tca cca ggt tat ata gat acc   624
Arg Asp Phe Ala Arg Val Asn Ser Ile Ser Pro Gly Tyr Ile Asp Thr
        195                 200                 205
 
ggt ttg tct gat ttt att gat gaa aag act caa gaa ttg tgg aga tct   672
Gly Leu Ser Asp Phe Ile Asp Glu Lys Thr Gln Glu Leu Trp Arg Ser
    210                 215                 220
 
atg att cca atg ggt aga aat ggt gat gct aaa gaa tta aaa ggt gct   720
Met Ile Pro Met Gly Arg Asn Gly Asp Ala Lys Glu Leu Lys Gly Ala
225                 230                 235                 240
 
tat gtt tat ttg gtt tca gat gct tct tct tat act act ggt gct gat   768
Tyr Val Tyr Leu Val Ser Asp Ala Ser Ser Tyr Thr Thr Gly Ala Asp
                245                 250                 255
 
ata gta att gat ggt ggt tat act act aga                           798
Ile Val Ile Asp Gly Gly Tyr Thr Thr Arg
            260                 265
 

<210> 148
<211> 266
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in S. cerevisiae

<400> 148
Met Pro Gln Pro Val Pro Thr Ala Asn Arg Leu Leu Asp Leu Phe Ser
 1               5                  10                  15      
Leu Lys Gly Lys Val Val Val Val Thr Gly Ala Ser Gly Pro Arg Gly
            20                  25                  30          
Met Gly Ile Glu Ala Ala Arg Gly Cys Ala Glu Met Gly Ala Asp Leu
        35                  40                  45              
Ala Ile Thr Tyr Ser Ser Arg Lys Glu Gly Ala Glu Lys Asn Ala Glu
    50                  55                  60                  
Glu Leu Thr Lys Glu Tyr Gly Val Lys Val Lys Val Tyr Lys Val Asn
65                  70                  75                  80  
Gln Ser Asp Tyr Asn Asp Val Glu Arg Phe Val Asn Gln Val Val Ser
                85                  90                  95      
Asp Phe Gly Lys Ile Asp Ala Phe Ile Ala Asn Ala Gly Ala Thr Ala
            100                 105                 110         
Asn Ser Gly Val Val Asp Gly Ser Ala Ser Asp Trp Asp His Val Ile
        115                 120                 125             
Gln Val Asp Leu Ser Gly Thr Ala Tyr Cys Ala Lys Ala Val Gly Ala
    130                 135                 140                 
His Phe Lys Lys Gln Gly His Gly Ser Leu Val Ile Thr Ala Ser Met
145                 150                 155                 160 
Ser Gly His Val Ala Asn Tyr Pro Gln Glu Gln Thr Ser Tyr Asn Val
                165                 170                 175     
Ala Lys Ala Gly Cys Ile His Leu Ala Arg Ser Leu Ala Asn Glu Trp
            180                 185                 190         
Arg Asp Phe Ala Arg Val Asn Ser Ile Ser Pro Gly Tyr Ile Asp Thr
        195                 200                 205             
Gly Leu Ser Asp Phe Ile Asp Glu Lys Thr Gln Glu Leu Trp Arg Ser
    210                 215                 220                 
Met Ile Pro Met Gly Arg Asn Gly Asp Ala Lys Glu Leu Lys Gly Ala
225                 230                 235                 240 
Tyr Val Tyr Leu Val Ser Asp Ala Ser Ser Tyr Thr Thr Gly Ala Asp
                245                 250                 255     
Ile Val Ile Asp Gly Gly Tyr Thr Thr Arg
            260                 265     


<210> 149
<211> 820
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in S. cerevisiae

<220> 
<221> CDS            
<222> (12)...(809)

<400> 149
tactcaagct t atg cca caa cct gtt cca act gct aat aga ttg tta gat  50
             Met Pro Gln Pro Val Pro Thr Ala Asn Arg Leu Leu Asp
              1               5                   10
 
ttg ttt tct tta aaa ggt aaa gta gtt gtt gtt act ggt gct tct ggt   98
Leu Phe Ser Leu Lys Gly Lys Val Val Val Val Thr Gly Ala Ser Gly
     15                  20                  25
 
cct aga ggt atg gga att gaa gct gct aga gga tgt gct gaa atg gga   146
Pro Arg Gly Met Gly Ile Glu Ala Ala Arg Gly Cys Ala Glu Met Gly
 30                  35                  40                  45
 
gca gat tta gct att act tat tct tct aga aag gaa gga gct gag aaa   194
Ala Asp Leu Ala Ile Thr Tyr Ser Ser Arg Lys Glu Gly Ala Glu Lys
                 50                  55                  60
 
aat gct gag gaa ttg act aaa gaa tat ggt gtt aaa gta aaa gta tat   242
Asn Ala Glu Glu Leu Thr Lys Glu Tyr Gly Val Lys Val Lys Val Tyr
             65                  70                  75
 
aag gtt aat caa tct gat tat aat gat gtt gaa aga ttt gta aat caa   290
Lys Val Asn Gln Ser Asp Tyr Asn Asp Val Glu Arg Phe Val Asn Gln
         80                  85                  90
 
gtt gtt tca gat ttc ggt aaa att gat gct ttt att gct aac gct gga   338
Val Val Ser Asp Phe Gly Lys Ile Asp Ala Phe Ile Ala Asn Ala Gly
     95                 100                 105
 
gct acc gct aat tct ggt gtt gtt gat ggt tct gct tca gat tgg gat   386
Ala Thr Ala Asn Ser Gly Val Val Asp Gly Ser Ala Ser Asp Trp Asp
110                 115                 120                 125
 
cat gtt ata caa gtt gat ttg tct gga act gct tat tgt gca aag gct   434
His Val Ile Gln Val Asp Leu Ser Gly Thr Ala Tyr Cys Ala Lys Ala
                130                 135                 140
 
gta ggt gct cat ttt aaa aag caa ggt cat ggt tct ttg gtt ata aca   482
Val Gly Ala His Phe Lys Lys Gln Gly His Gly Ser Leu Val Ile Thr
            145                 150                 155
 
gct tct atg tct ggt cat gtt gct aat tat cca caa gaa caa act tca   530
Ala Ser Met Ser Gly His Val Ala Asn Tyr Pro Gln Glu Gln Thr Ser
        160                 165                 170
 
tat aat gtt gca aaa gct ggt tgt att cat ttg gct aga tct ttg gct   578
Tyr Asn Val Ala Lys Ala Gly Cys Ile His Leu Ala Arg Ser Leu Ala
    175                 180                 185
 
aat gaa tgg aga gat ttt gct aga gtt aat tct att tca cca ggt tat   626
Asn Glu Trp Arg Asp Phe Ala Arg Val Asn Ser Ile Ser Pro Gly Tyr
190                 195                 200                 205
 
ata gat acc ggt ttg tct gat ttt att gat gaa aag act caa gaa ttg   674
Ile Asp Thr Gly Leu Ser Asp Phe Ile Asp Glu Lys Thr Gln Glu Leu
                210                 215                 220
 
tgg aga tct atg att cca atg ggt aga aat ggt gat gct aaa gaa tta   722
Trp Arg Ser Met Ile Pro Met Gly Arg Asn Gly Asp Ala Lys Glu Leu
            225                 230                 235
 
aaa ggt gct tat gtt tat ttg gtt tca gat gct tct tct tat act act   770
Lys Gly Ala Tyr Val Tyr Leu Val Ser Asp Ala Ser Ser Tyr Thr Thr
        240                 245                 250
 
ggt gct gat ata gta att gat ggt ggt tat act act aga gaattccgat    819
Gly Ala Asp Ile Val Ile Asp Gly Gly Tyr Thr Thr Arg
    255                 260                 265
 
g                                                                 820

<210> 150
<211> 266
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in S. cerevisiae

<400> 150
Met Pro Gln Pro Val Pro Thr Ala Asn Arg Leu Leu Asp Leu Phe Ser
 1               5                  10                  15      
Leu Lys Gly Lys Val Val Val Val Thr Gly Ala Ser Gly Pro Arg Gly
            20                  25                  30          
Met Gly Ile Glu Ala Ala Arg Gly Cys Ala Glu Met Gly Ala Asp Leu
        35                  40                  45              
Ala Ile Thr Tyr Ser Ser Arg Lys Glu Gly Ala Glu Lys Asn Ala Glu
    50                  55                  60                  
Glu Leu Thr Lys Glu Tyr Gly Val Lys Val Lys Val Tyr Lys Val Asn
65                  70                  75                  80  
Gln Ser Asp Tyr Asn Asp Val Glu Arg Phe Val Asn Gln Val Val Ser
                85                  90                  95      
Asp Phe Gly Lys Ile Asp Ala Phe Ile Ala Asn Ala Gly Ala Thr Ala
            100                 105                 110         
Asn Ser Gly Val Val Asp Gly Ser Ala Ser Asp Trp Asp His Val Ile
        115                 120                 125             
Gln Val Asp Leu Ser Gly Thr Ala Tyr Cys Ala Lys Ala Val Gly Ala
    130                 135                 140                 
His Phe Lys Lys Gln Gly His Gly Ser Leu Val Ile Thr Ala Ser Met
145                 150                 155                 160 
Ser Gly His Val Ala Asn Tyr Pro Gln Glu Gln Thr Ser Tyr Asn Val
                165                 170                 175     
Ala Lys Ala Gly Cys Ile His Leu Ala Arg Ser Leu Ala Asn Glu Trp
            180                 185                 190         
Arg Asp Phe Ala Arg Val Asn Ser Ile Ser Pro Gly Tyr Ile Asp Thr
        195                 200                 205             
Gly Leu Ser Asp Phe Ile Asp Glu Lys Thr Gln Glu Leu Trp Arg Ser
    210                 215                 220                 
Met Ile Pro Met Gly Arg Asn Gly Asp Ala Lys Glu Leu Lys Gly Ala
225                 230                 235                 240 
Tyr Val Tyr Leu Val Ser Asp Ala Ser Ser Tyr Thr Thr Gly Ala Asp
                245                 250                 255     
Ile Val Ile Asp Gly Gly Tyr Thr Thr Arg
            260                 265     


<210> 151
<211> 826
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in S. cerevisiae

<220> 
<221> CDS            
<222> (15)...(812)

<400> 151
gaatactcca tatg atg cca caa cct gtt cca act gct aat aga ttg tta   50
                Met Pro Gln Pro Val Pro Thr Ala Asn Arg Leu Leu
                 1               5                   10
 
gat ttg ttt tct tta aaa ggt aaa gta gtt gtt gtt act ggt gct tct   98
Asp Leu Phe Ser Leu Lys Gly Lys Val Val Val Val Thr Gly Ala Ser
         15                  20                  25
 
ggt cct aga ggt atg gga att gaa gct gct aga gga tgt gct gaa atg   146
Gly Pro Arg Gly Met Gly Ile Glu Ala Ala Arg Gly Cys Ala Glu Met
     30                  35                  40
 
gga gca gat tta gct att act tat tct tct aga aag gaa gga gct gag   194
Gly Ala Asp Leu Ala Ile Thr Tyr Ser Ser Arg Lys Glu Gly Ala Glu
 45                  50                  55                  60
 
aaa aat gct gag gaa ttg act aaa gaa tat ggt gtt aaa gta aaa gta   242
Lys Asn Ala Glu Glu Leu Thr Lys Glu Tyr Gly Val Lys Val Lys Val
                 65                  70                  75
 
tat aag gtt aat caa tct gat tat aat gat gtt gaa aga ttt gta aat   290
Tyr Lys Val Asn Gln Ser Asp Tyr Asn Asp Val Glu Arg Phe Val Asn
             80                  85                  90
 
caa gtt gtt tca gat ttc ggt aaa att gat gct ttt att gct aac gct   338
Gln Val Val Ser Asp Phe Gly Lys Ile Asp Ala Phe Ile Ala Asn Ala
         95                 100                 105
 
gga gct acc gct aat tct ggt gtt gtt gat ggt tct gct tca gat tgg   386
Gly Ala Thr Ala Asn Ser Gly Val Val Asp Gly Ser Ala Ser Asp Trp
    110                 115                 120
 
gat cat gtt ata caa gtt gat ttg tct gga act gct tat tgt gca aag   434
Asp His Val Ile Gln Val Asp Leu Ser Gly Thr Ala Tyr Cys Ala Lys
125                 130                 135                 140
 
gct gta ggt gct cat ttt aaa aag caa ggt cat ggt tct ttg gtt ata   482
Ala Val Gly Ala His Phe Lys Lys Gln Gly His Gly Ser Leu Val Ile
                145                 150                 155
 
aca gct tct atg tct ggt cat gtt gct aat tat cca caa gaa caa act   530
Thr Ala Ser Met Ser Gly His Val Ala Asn Tyr Pro Gln Glu Gln Thr
            160                 165                 170
 
tca tat aat gtt gca aaa gct ggt tgt att cat ttg gct aga tct ttg   578
Ser Tyr Asn Val Ala Lys Ala Gly Cys Ile His Leu Ala Arg Ser Leu
        175                 180                 185
 
gct aat gaa tgg aga gat ttt gct aga gtt aat tct att tca cca ggt   626
Ala Asn Glu Trp Arg Asp Phe Ala Arg Val Asn Ser Ile Ser Pro Gly
    190                 195                 200
 
tat ata gat acc ggt ttg tct gat ttt att gat gaa aag act caa gaa   674
Tyr Ile Asp Thr Gly Leu Ser Asp Phe Ile Asp Glu Lys Thr Gln Glu
205                 210                 215                 220
 
ttg tgg aga tct atg att cca atg ggt aga aat ggt gat gct aaa gaa   722
Leu Trp Arg Ser Met Ile Pro Met Gly Arg Asn Gly Asp Ala Lys Glu
                225                 230                 235
 
tta aaa ggt gct tat gtt tat ttg gtt tca gat gct tct tct tat act   770
Leu Lys Gly Ala Tyr Val Tyr Leu Val Ser Asp Ala Ser Ser Tyr Thr
            240                 245                 250
 
act ggt gct gat ata gta att gat ggt ggt tat act act aga           812
Thr Gly Ala Asp Ile Val Ile Asp Gly Gly Tyr Thr Thr Arg
        255                 260                 265
 
actagtcgat gcct                                                   826

<210> 152
<211> 266
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in S. cerevisiae

<400> 152
Met Pro Gln Pro Val Pro Thr Ala Asn Arg Leu Leu Asp Leu Phe Ser
 1               5                  10                  15      
Leu Lys Gly Lys Val Val Val Val Thr Gly Ala Ser Gly Pro Arg Gly
            20                  25                  30          
Met Gly Ile Glu Ala Ala Arg Gly Cys Ala Glu Met Gly Ala Asp Leu
        35                  40                  45              
Ala Ile Thr Tyr Ser Ser Arg Lys Glu Gly Ala Glu Lys Asn Ala Glu
    50                  55                  60                  
Glu Leu Thr Lys Glu Tyr Gly Val Lys Val Lys Val Tyr Lys Val Asn
65                  70                  75                  80  
Gln Ser Asp Tyr Asn Asp Val Glu Arg Phe Val Asn Gln Val Val Ser
                85                  90                  95      
Asp Phe Gly Lys Ile Asp Ala Phe Ile Ala Asn Ala Gly Ala Thr Ala
            100                 105                 110         
Asn Ser Gly Val Val Asp Gly Ser Ala Ser Asp Trp Asp His Val Ile
        115                 120                 125             
Gln Val Asp Leu Ser Gly Thr Ala Tyr Cys Ala Lys Ala Val Gly Ala
    130                 135                 140                 
His Phe Lys Lys Gln Gly His Gly Ser Leu Val Ile Thr Ala Ser Met
145                 150                 155                 160 
Ser Gly His Val Ala Asn Tyr Pro Gln Glu Gln Thr Ser Tyr Asn Val
                165                 170                 175     
Ala Lys Ala Gly Cys Ile His Leu Ala Arg Ser Leu Ala Asn Glu Trp
            180                 185                 190         
Arg Asp Phe Ala Arg Val Asn Ser Ile Ser Pro Gly Tyr Ile Asp Thr
        195                 200                 205             
Gly Leu Ser Asp Phe Ile Asp Glu Lys Thr Gln Glu Leu Trp Arg Ser
    210                 215                 220                 
Met Ile Pro Met Gly Arg Asn Gly Asp Ala Lys Glu Leu Lys Gly Ala
225                 230                 235                 240 
Tyr Val Tyr Leu Val Ser Asp Ala Ser Ser Tyr Thr Thr Gly Ala Asp
                245                 250                 255     
Ile Val Ile Asp Gly Gly Tyr Thr Thr Arg
            260                 265     


<210> 153
<211> 798
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in E. coli

<220> 
<221> CDS            
<222> (1)...(798)

<400> 153
atg cca caa cct gtt cca act gct aat aga ttg tta gat ttg ttt tct   48
Met Pro Gln Pro Val Pro Thr Ala Asn Arg Leu Leu Asp Leu Phe Ser
 1               5                   10                  15
 
tta aaa ggt aaa gta gtt gtt gtt act ggt gct tct ggt cct aga ggt   96
Leu Lys Gly Lys Val Val Val Val Thr Gly Ala Ser Gly Pro Arg Gly
             20                  25                  30
 
atg gga att gaa gct gct aga gga tgt gct gaa atg gga gca gat tta   144
Met Gly Ile Glu Ala Ala Arg Gly Cys Ala Glu Met Gly Ala Asp Leu
         35                  40                  45
 
gct att act tat tct tct aga aag gaa gga gct gag aaa aat gct gag   192
Ala Ile Thr Tyr Ser Ser Arg Lys Glu Gly Ala Glu Lys Asn Ala Glu
     50                  55                  60
 
gaa ttg act aaa gaa tat ggt gtt aaa gta aaa gta tat aag gtt aat   240
Glu Leu Thr Lys Glu Tyr Gly Val Lys Val Lys Val Tyr Lys Val Asn
 65                  70                  75                  80
 
caa tct gat tat aat gat gtt gaa aga ttt gta aat caa gtt gtt tca   288
Gln Ser Asp Tyr Asn Asp Val Glu Arg Phe Val Asn Gln Val Val Ser
                 85                  90                  95
 
gat ttc ggt aaa att gat gct ttt att gct aac gct gga gct acc gct   336
Asp Phe Gly Lys Ile Asp Ala Phe Ile Ala Asn Ala Gly Ala Thr Ala
            100                 105                 110
 
aat tct ggt gtt gtt gat ggt tct gct tca gat tgg gat cat gtt ata   384
Asn Ser Gly Val Val Asp Gly Ser Ala Ser Asp Trp Asp His Val Ile
        115                 120                 125
 
caa gtt gat ttg tct gga act gct tat tgt gca aag gct gta ggt gct   432
Gln Val Asp Leu Ser Gly Thr Ala Tyr Cys Ala Lys Ala Val Gly Ala
    130                 135                 140
 
cat ttt aaa aag caa ggt cat ggt tct ttg gtt ata aca gct tct atg   480
His Phe Lys Lys Gln Gly His Gly Ser Leu Val Ile Thr Ala Ser Met
145                 150                 155                 160
 
tct ggt cat gtt gct aat tat cca caa gaa caa act tca tat aat gtt   528
Ser Gly His Val Ala Asn Tyr Pro Gln Glu Gln Thr Ser Tyr Asn Val
                165                 170                 175
 
gca aaa gct ggt tgt att cat ttg gct aga tct ttg gct aat gaa tgg   576
Ala Lys Ala Gly Cys Ile His Leu Ala Arg Ser Leu Ala Asn Glu Trp
            180                 185                 190
 
aga gat ttt gct aga gtt aat tct att tca cca ggt tat ata gat acc   624
Arg Asp Phe Ala Arg Val Asn Ser Ile Ser Pro Gly Tyr Ile Asp Thr
        195                 200                 205
 
ggt ttg tct gat ttt att gat gaa aag act caa gaa ttg tgg aga tct   672
Gly Leu Ser Asp Phe Ile Asp Glu Lys Thr Gln Glu Leu Trp Arg Ser
    210                 215                 220
 
atg att cca atg ggt aga aat ggt gat gct aaa gaa tta aaa ggt gct   720
Met Ile Pro Met Gly Arg Asn Gly Asp Ala Lys Glu Leu Lys Gly Ala
225                 230                 235                 240
 
tat gtt tat ttg gtt tca gat gct tct tct tat act act ggt gct gat   768
Tyr Val Tyr Leu Val Ser Asp Ala Ser Ser Tyr Thr Thr Gly Ala Asp
                245                 250                 255
 
ata gta att gat ggt ggt tat act act aga                           798
Ile Val Ile Asp Gly Gly Tyr Thr Thr Arg
            260                 265
 

<210> 154
<211> 266
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in E. coli

<400> 154
Met Pro Gln Pro Val Pro Thr Ala Asn Arg Leu Leu Asp Leu Phe Ser
 1               5                  10                  15      
Leu Lys Gly Lys Val Val Val Val Thr Gly Ala Ser Gly Pro Arg Gly
            20                  25                  30          
Met Gly Ile Glu Ala Ala Arg Gly Cys Ala Glu Met Gly Ala Asp Leu
        35                  40                  45              
Ala Ile Thr Tyr Ser Ser Arg Lys Glu Gly Ala Glu Lys Asn Ala Glu
    50                  55                  60                  
Glu Leu Thr Lys Glu Tyr Gly Val Lys Val Lys Val Tyr Lys Val Asn
65                  70                  75                  80  
Gln Ser Asp Tyr Asn Asp Val Glu Arg Phe Val Asn Gln Val Val Ser
                85                  90                  95      
Asp Phe Gly Lys Ile Asp Ala Phe Ile Ala Asn Ala Gly Ala Thr Ala
            100                 105                 110         
Asn Ser Gly Val Val Asp Gly Ser Ala Ser Asp Trp Asp His Val Ile
        115                 120                 125             
Gln Val Asp Leu Ser Gly Thr Ala Tyr Cys Ala Lys Ala Val Gly Ala
    130                 135                 140                 
His Phe Lys Lys Gln Gly His Gly Ser Leu Val Ile Thr Ala Ser Met
145                 150                 155                 160 
Ser Gly His Val Ala Asn Tyr Pro Gln Glu Gln Thr Ser Tyr Asn Val
                165                 170                 175     
Ala Lys Ala Gly Cys Ile His Leu Ala Arg Ser Leu Ala Asn Glu Trp
            180                 185                 190         
Arg Asp Phe Ala Arg Val Asn Ser Ile Ser Pro Gly Tyr Ile Asp Thr
        195                 200                 205             
Gly Leu Ser Asp Phe Ile Asp Glu Lys Thr Gln Glu Leu Trp Arg Ser
    210                 215                 220                 
Met Ile Pro Met Gly Arg Asn Gly Asp Ala Lys Glu Leu Lys Gly Ala
225                 230                 235                 240 
Tyr Val Tyr Leu Val Ser Asp Ala Ser Ser Tyr Thr Thr Gly Ala Asp
                245                 250                 255     
Ile Val Ile Asp Gly Gly Tyr Thr Thr Arg
            260                 265     


<210> 155
<211> 820
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in E. coli

<220> 
<221> CDS            
<222> (12)...(809)

<400> 155
tactcaagct t atg cca caa cct gtt cca act gct aat aga ttg tta gat  50
             Met Pro Gln Pro Val Pro Thr Ala Asn Arg Leu Leu Asp
              1               5                   10
 
ttg ttt tct tta aaa ggt aaa gta gtt gtt gtt act ggt gct tct ggt   98
Leu Phe Ser Leu Lys Gly Lys Val Val Val Val Thr Gly Ala Ser Gly
     15                  20                  25
 
cct aga ggt atg gga att gaa gct gct aga gga tgt gct gaa atg gga   146
Pro Arg Gly Met Gly Ile Glu Ala Ala Arg Gly Cys Ala Glu Met Gly
 30                  35                  40                  45
 
gca gat tta gct att act tat tct tct aga aag gaa gga gct gag aaa   194
Ala Asp Leu Ala Ile Thr Tyr Ser Ser Arg Lys Glu Gly Ala Glu Lys
                 50                  55                  60
 
aat gct gag gaa ttg act aaa gaa tat ggt gtt aaa gta aaa gta tat   242
Asn Ala Glu Glu Leu Thr Lys Glu Tyr Gly Val Lys Val Lys Val Tyr
             65                  70                  75
 
aag gtt aat caa tct gat tat aat gat gtt gaa aga ttt gta aat caa   290
Lys Val Asn Gln Ser Asp Tyr Asn Asp Val Glu Arg Phe Val Asn Gln
         80                  85                  90
 
gtt gtt tca gat ttc ggt aaa att gat gct ttt att gct aac gct gga   338
Val Val Ser Asp Phe Gly Lys Ile Asp Ala Phe Ile Ala Asn Ala Gly
     95                 100                 105
 
gct acc gct aat tct ggt gtt gtt gat ggt tct gct tca gat tgg gat   386
Ala Thr Ala Asn Ser Gly Val Val Asp Gly Ser Ala Ser Asp Trp Asp
110                 115                 120                 125
 
cat gtt ata caa gtt gat ttg tct gga act gct tat tgt gca aag gct   434
His Val Ile Gln Val Asp Leu Ser Gly Thr Ala Tyr Cys Ala Lys Ala
                130                 135                 140
 
gta ggt gct cat ttt aaa aag caa ggt cat ggt tct ttg gtt ata aca   482
Val Gly Ala His Phe Lys Lys Gln Gly His Gly Ser Leu Val Ile Thr
            145                 150                 155
 
gct tct atg tct ggt cat gtt gct aat tat cca caa gaa caa act tca   530
Ala Ser Met Ser Gly His Val Ala Asn Tyr Pro Gln Glu Gln Thr Ser
        160                 165                 170
 
tat aat gtt gca aaa gct ggt tgt att cat ttg gct aga tct ttg gct   578
Tyr Asn Val Ala Lys Ala Gly Cys Ile His Leu Ala Arg Ser Leu Ala
    175                 180                 185
 
aat gaa tgg aga gat ttt gct aga gtt aat tct att tca cca ggt tat   626
Asn Glu Trp Arg Asp Phe Ala Arg Val Asn Ser Ile Ser Pro Gly Tyr
190                 195                 200                 205
 
ata gat acc ggt ttg tct gat ttt att gat gaa aag act caa gaa ttg   674
Ile Asp Thr Gly Leu Ser Asp Phe Ile Asp Glu Lys Thr Gln Glu Leu
                210                 215                 220
 
tgg aga tct atg att cca atg ggt aga aat ggt gat gct aaa gaa tta   722
Trp Arg Ser Met Ile Pro Met Gly Arg Asn Gly Asp Ala Lys Glu Leu
            225                 230                 235
 
aaa ggt gct tat gtt tat ttg gtt tca gat gct tct tct tat act act   770
Lys Gly Ala Tyr Val Tyr Leu Val Ser Asp Ala Ser Ser Tyr Thr Thr
        240                 245                 250
 
ggt gct gat ata gta att gat ggt ggt tat act act aga gaattccgat    819
Gly Ala Asp Ile Val Ile Asp Gly Gly Tyr Thr Thr Arg
    255                 260                 265
 
g                                                                 820

<210> 156
<211> 266
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in E. coli

<400> 156
Met Pro Gln Pro Val Pro Thr Ala Asn Arg Leu Leu Asp Leu Phe Ser
 1               5                  10                  15      
Leu Lys Gly Lys Val Val Val Val Thr Gly Ala Ser Gly Pro Arg Gly
            20                  25                  30          
Met Gly Ile Glu Ala Ala Arg Gly Cys Ala Glu Met Gly Ala Asp Leu
        35                  40                  45              
Ala Ile Thr Tyr Ser Ser Arg Lys Glu Gly Ala Glu Lys Asn Ala Glu
    50                  55                  60                  
Glu Leu Thr Lys Glu Tyr Gly Val Lys Val Lys Val Tyr Lys Val Asn
65                  70                  75                  80  
Gln Ser Asp Tyr Asn Asp Val Glu Arg Phe Val Asn Gln Val Val Ser
                85                  90                  95      
Asp Phe Gly Lys Ile Asp Ala Phe Ile Ala Asn Ala Gly Ala Thr Ala
            100                 105                 110         
Asn Ser Gly Val Val Asp Gly Ser Ala Ser Asp Trp Asp His Val Ile
        115                 120                 125             
Gln Val Asp Leu Ser Gly Thr Ala Tyr Cys Ala Lys Ala Val Gly Ala
    130                 135                 140                 
His Phe Lys Lys Gln Gly His Gly Ser Leu Val Ile Thr Ala Ser Met
145                 150                 155                 160 
Ser Gly His Val Ala Asn Tyr Pro Gln Glu Gln Thr Ser Tyr Asn Val
                165                 170                 175     
Ala Lys Ala Gly Cys Ile His Leu Ala Arg Ser Leu Ala Asn Glu Trp
            180                 185                 190         
Arg Asp Phe Ala Arg Val Asn Ser Ile Ser Pro Gly Tyr Ile Asp Thr
        195                 200                 205             
Gly Leu Ser Asp Phe Ile Asp Glu Lys Thr Gln Glu Leu Trp Arg Ser
    210                 215                 220                 
Met Ile Pro Met Gly Arg Asn Gly Asp Ala Lys Glu Leu Lys Gly Ala
225                 230                 235                 240 
Tyr Val Tyr Leu Val Ser Asp Ala Ser Ser Tyr Thr Thr Gly Ala Asp
                245                 250                 255     
Ile Val Ile Asp Gly Gly Tyr Thr Thr Arg
            260                 265     


<210> 157
<211> 826
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in E. coli

<220> 
<221> CDS            
<222> (15)...(812)

<400> 157
gaatactcca tatg atg cca caa cct gtt cca act gct aat aga ttg tta   50
                Met Pro Gln Pro Val Pro Thr Ala Asn Arg Leu Leu
                 1               5                   10
 
gat ttg ttt tct tta aaa ggt aaa gta gtt gtt gtt act ggt gct tct   98
Asp Leu Phe Ser Leu Lys Gly Lys Val Val Val Val Thr Gly Ala Ser
         15                  20                  25
 
ggt cct aga ggt atg gga att gaa gct gct aga gga tgt gct gaa atg   146
Gly Pro Arg Gly Met Gly Ile Glu Ala Ala Arg Gly Cys Ala Glu Met
     30                  35                  40
 
gga gca gat tta gct att act tat tct tct aga aag gaa gga gct gag   194
Gly Ala Asp Leu Ala Ile Thr Tyr Ser Ser Arg Lys Glu Gly Ala Glu
 45                  50                  55                  60
 
aaa aat gct gag gaa ttg act aaa gaa tat ggt gtt aaa gta aaa gta   242
Lys Asn Ala Glu Glu Leu Thr Lys Glu Tyr Gly Val Lys Val Lys Val
                 65                  70                  75
 
tat aag gtt aat caa tct gat tat aat gat gtt gaa aga ttt gta aat   290
Tyr Lys Val Asn Gln Ser Asp Tyr Asn Asp Val Glu Arg Phe Val Asn
             80                  85                  90
 
caa gtt gtt tca gat ttc ggt aaa att gat gct ttt att gct aac gct   338
Gln Val Val Ser Asp Phe Gly Lys Ile Asp Ala Phe Ile Ala Asn Ala
         95                 100                 105
 
gga gct acc gct aat tct ggt gtt gtt gat ggt tct gct tca gat tgg   386
Gly Ala Thr Ala Asn Ser Gly Val Val Asp Gly Ser Ala Ser Asp Trp
    110                 115                 120
 
gat cat gtt ata caa gtt gat ttg tct gga act gct tat tgt gca aag   434
Asp His Val Ile Gln Val Asp Leu Ser Gly Thr Ala Tyr Cys Ala Lys
125                 130                 135                 140
 
gct gta ggt gct cat ttt aaa aag caa ggt cat ggt tct ttg gtt ata   482
Ala Val Gly Ala His Phe Lys Lys Gln Gly His Gly Ser Leu Val Ile
                145                 150                 155
 
aca gct tct atg tct ggt cat gtt gct aat tat cca caa gaa caa act   530
Thr Ala Ser Met Ser Gly His Val Ala Asn Tyr Pro Gln Glu Gln Thr
            160                 165                 170
 
tca tat aat gtt gca aaa gct ggt tgt att cat ttg gct aga tct ttg   578
Ser Tyr Asn Val Ala Lys Ala Gly Cys Ile His Leu Ala Arg Ser Leu
        175                 180                 185
 
gct aat gaa tgg aga gat ttt gct aga gtt aat tct att tca cca ggt   626
Ala Asn Glu Trp Arg Asp Phe Ala Arg Val Asn Ser Ile Ser Pro Gly
    190                 195                 200
 
tat ata gat acc ggt ttg tct gat ttt att gat gaa aag act caa gaa   674
Tyr Ile Asp Thr Gly Leu Ser Asp Phe Ile Asp Glu Lys Thr Gln Glu
205                 210                 215                 220
 
ttg tgg aga tct atg att cca atg ggt aga aat ggt gat gct aaa gaa   722
Leu Trp Arg Ser Met Ile Pro Met Gly Arg Asn Gly Asp Ala Lys Glu
                225                 230                 235
 
tta aaa ggt gct tat gtt tat ttg gtt tca gat gct tct tct tat act   770
Leu Lys Gly Ala Tyr Val Tyr Leu Val Ser Asp Ala Ser Ser Tyr Thr
            240                 245                 250
 
act ggt gct gat ata gta att gat ggt ggt tat act act aga           812
Thr Gly Ala Asp Ile Val Ile Asp Gly Gly Tyr Thr Thr Arg
        255                 260                 265
 
actagtcgat gcct                                                   826

<210> 158
<211> 266
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in E. coli

<400> 158
Met Pro Gln Pro Val Pro Thr Ala Asn Arg Leu Leu Asp Leu Phe Ser
 1               5                  10                  15      
Leu Lys Gly Lys Val Val Val Val Thr Gly Ala Ser Gly Pro Arg Gly
            20                  25                  30          
Met Gly Ile Glu Ala Ala Arg Gly Cys Ala Glu Met Gly Ala Asp Leu
        35                  40                  45              
Ala Ile Thr Tyr Ser Ser Arg Lys Glu Gly Ala Glu Lys Asn Ala Glu
    50                  55                  60                  
Glu Leu Thr Lys Glu Tyr Gly Val Lys Val Lys Val Tyr Lys Val Asn
65                  70                  75                  80  
Gln Ser Asp Tyr Asn Asp Val Glu Arg Phe Val Asn Gln Val Val Ser
                85                  90                  95      
Asp Phe Gly Lys Ile Asp Ala Phe Ile Ala Asn Ala Gly Ala Thr Ala
            100                 105                 110         
Asn Ser Gly Val Val Asp Gly Ser Ala Ser Asp Trp Asp His Val Ile
        115                 120                 125             
Gln Val Asp Leu Ser Gly Thr Ala Tyr Cys Ala Lys Ala Val Gly Ala
    130                 135                 140                 
His Phe Lys Lys Gln Gly His Gly Ser Leu Val Ile Thr Ala Ser Met
145                 150                 155                 160 
Ser Gly His Val Ala Asn Tyr Pro Gln Glu Gln Thr Ser Tyr Asn Val
                165                 170                 175     
Ala Lys Ala Gly Cys Ile His Leu Ala Arg Ser Leu Ala Asn Glu Trp
            180                 185                 190         
Arg Asp Phe Ala Arg Val Asn Ser Ile Ser Pro Gly Tyr Ile Asp Thr
        195                 200                 205             
Gly Leu Ser Asp Phe Ile Asp Glu Lys Thr Gln Glu Leu Trp Arg Ser
    210                 215                 220                 
Met Ile Pro Met Gly Arg Asn Gly Asp Ala Lys Glu Leu Lys Gly Ala
225                 230                 235                 240 
Tyr Val Tyr Leu Val Ser Asp Ala Ser Ser Tyr Thr Thr Gly Ala Asp
                245                 250                 255     
Ile Val Ile Asp Gly Gly Tyr Thr Thr Arg
            260                 265     


<210> 159
<211> 798
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in P. pastoris

<220> 
<221> CDS            
<222> (1)...(798)

<400> 159
atg cca caa cca gtt cca aca gct aat aga ttg tta gat ttg ttt tct   48
Met Pro Gln Pro Val Pro Thr Ala Asn Arg Leu Leu Asp Leu Phe Ser
 1               5                   10                  15
 
tta aaa gga aaa gtg gtt gtt gtt act gga gct tct gga cct aga gga   96
Leu Lys Gly Lys Val Val Val Val Thr Gly Ala Ser Gly Pro Arg Gly
             20                  25                  30
 
atg gga att gag gct gct aga gga tgt gct gaa atg ggc gct gat tta   144
Met Gly Ile Glu Ala Ala Arg Gly Cys Ala Glu Met Gly Ala Asp Leu
         35                  40                  45
 
gct att act tat tct tct aga aag gaa gga gct gag aaa aat gca gaa   192
Ala Ile Thr Tyr Ser Ser Arg Lys Glu Gly Ala Glu Lys Asn Ala Glu
     50                  55                  60
 
gaa ttg act aaa gaa tat gga gtt aaa gtt aaa gtt tat aaa gtt aat   240
Glu Leu Thr Lys Glu Tyr Gly Val Lys Val Lys Val Tyr Lys Val Asn
 65                  70                  75                  80
 
caa tct gat tat aat gat gtt gaa aga ttt gtt aat caa gtt gtt tct   288
Gln Ser Asp Tyr Asn Asp Val Glu Arg Phe Val Asn Gln Val Val Ser
                 85                  90                  95
 
gat ttt ggt aaa att gat gct ttt att gct aac gct ggt gct act gct   336
Asp Phe Gly Lys Ile Asp Ala Phe Ile Ala Asn Ala Gly Ala Thr Ala
            100                 105                 110
 
aat tct ggt gtt gtt gat gga tct gct tct gat tgg gat cat gtt att   384
Asn Ser Gly Val Val Asp Gly Ser Ala Ser Asp Trp Asp His Val Ile
        115                 120                 125
 
caa gtt gat ttg tca gga aca gca tat tgt gca aaa gca gtg gga gcc   432
Gln Val Asp Leu Ser Gly Thr Ala Tyr Cys Ala Lys Ala Val Gly Ala
    130                 135                 140
 
cat ttt aaa aag caa gga cat gga tct tta gtt att act gca tct atg   480
His Phe Lys Lys Gln Gly His Gly Ser Leu Val Ile Thr Ala Ser Met
145                 150                 155                 160
 
tct gga cac gtt gct aat tat cca caa gaa caa aca tct tat aat gtt   528
Ser Gly His Val Ala Asn Tyr Pro Gln Glu Gln Thr Ser Tyr Asn Val
                165                 170                 175
 
gct aaa gct gga tgt att cat ttg gct aga tct tta gct aat gaa tgg   576
Ala Lys Ala Gly Cys Ile His Leu Ala Arg Ser Leu Ala Asn Glu Trp
            180                 185                 190
 
aga gat ttc gct aga gtt aat tct att tca cct ggt tat att gat act   624
Arg Asp Phe Ala Arg Val Asn Ser Ile Ser Pro Gly Tyr Ile Asp Thr
        195                 200                 205
 
gga ttg tct gat ttt att gat gaa aag act caa gaa ttg tgg aga tct   672
Gly Leu Ser Asp Phe Ile Asp Glu Lys Thr Gln Glu Leu Trp Arg Ser
    210                 215                 220
 
atg att cca atg ggt aga aat gga gat gct aaa gaa tta aaa gga gct   720
Met Ile Pro Met Gly Arg Asn Gly Asp Ala Lys Glu Leu Lys Gly Ala
225                 230                 235                 240
 
tat gtt tat ttg gtt tct gat gct tct tct tat act act gga gct gat   768
Tyr Val Tyr Leu Val Ser Asp Ala Ser Ser Tyr Thr Thr Gly Ala Asp
                245                 250                 255
 
ata gtt att gat gga gga tat act act aga                           798
Ile Val Ile Asp Gly Gly Tyr Thr Thr Arg
            260                 265
 

<210> 160
<211> 266
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in P. pastoris

<400> 160
Met Pro Gln Pro Val Pro Thr Ala Asn Arg Leu Leu Asp Leu Phe Ser
 1               5                  10                  15      
Leu Lys Gly Lys Val Val Val Val Thr Gly Ala Ser Gly Pro Arg Gly
            20                  25                  30          
Met Gly Ile Glu Ala Ala Arg Gly Cys Ala Glu Met Gly Ala Asp Leu
        35                  40                  45              
Ala Ile Thr Tyr Ser Ser Arg Lys Glu Gly Ala Glu Lys Asn Ala Glu
    50                  55                  60                  
Glu Leu Thr Lys Glu Tyr Gly Val Lys Val Lys Val Tyr Lys Val Asn
65                  70                  75                  80  
Gln Ser Asp Tyr Asn Asp Val Glu Arg Phe Val Asn Gln Val Val Ser
                85                  90                  95      
Asp Phe Gly Lys Ile Asp Ala Phe Ile Ala Asn Ala Gly Ala Thr Ala
            100                 105                 110         
Asn Ser Gly Val Val Asp Gly Ser Ala Ser Asp Trp Asp His Val Ile
        115                 120                 125             
Gln Val Asp Leu Ser Gly Thr Ala Tyr Cys Ala Lys Ala Val Gly Ala
    130                 135                 140                 
His Phe Lys Lys Gln Gly His Gly Ser Leu Val Ile Thr Ala Ser Met
145                 150                 155                 160 
Ser Gly His Val Ala Asn Tyr Pro Gln Glu Gln Thr Ser Tyr Asn Val
                165                 170                 175     
Ala Lys Ala Gly Cys Ile His Leu Ala Arg Ser Leu Ala Asn Glu Trp
            180                 185                 190         
Arg Asp Phe Ala Arg Val Asn Ser Ile Ser Pro Gly Tyr Ile Asp Thr
        195                 200                 205             
Gly Leu Ser Asp Phe Ile Asp Glu Lys Thr Gln Glu Leu Trp Arg Ser
    210                 215                 220                 
Met Ile Pro Met Gly Arg Asn Gly Asp Ala Lys Glu Leu Lys Gly Ala
225                 230                 235                 240 
Tyr Val Tyr Leu Val Ser Asp Ala Ser Ser Tyr Thr Thr Gly Ala Asp
                245                 250                 255     
Ile Val Ile Asp Gly Gly Tyr Thr Thr Arg
            260                 265     


<210> 161
<211> 826
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in P. pastoris

<220> 
<221> CDS            
<222> (15)...(812)

<400> 161
gaatactcca tatg atg cca caa cca gtt cca aca gct aat aga ttg tta   50
                Met Pro Gln Pro Val Pro Thr Ala Asn Arg Leu Leu
                 1               5                   10
 
gat ttg ttt tct tta aaa gga aaa gtg gtt gtt gtt act gga gct tct   98
Asp Leu Phe Ser Leu Lys Gly Lys Val Val Val Val Thr Gly Ala Ser
         15                  20                  25
 
gga cct aga gga atg gga att gag gct gct aga gga tgt gct gaa atg   146
Gly Pro Arg Gly Met Gly Ile Glu Ala Ala Arg Gly Cys Ala Glu Met
     30                  35                  40
 
ggc gct gat tta gct att act tat tct tct aga aag gaa gga gct gag   194
Gly Ala Asp Leu Ala Ile Thr Tyr Ser Ser Arg Lys Glu Gly Ala Glu
 45                  50                  55                  60
 
aaa aat gca gaa gaa ttg act aaa gaa tat gga gtt aaa gtt aaa gtt   242
Lys Asn Ala Glu Glu Leu Thr Lys Glu Tyr Gly Val Lys Val Lys Val
                 65                  70                  75
 
tat aaa gtt aat caa tct gat tat aat gat gtt gaa aga ttt gtt aat   290
Tyr Lys Val Asn Gln Ser Asp Tyr Asn Asp Val Glu Arg Phe Val Asn
             80                  85                  90
 
caa gtt gtt tct gat ttt ggt aaa att gat gct ttt att gct aac gct   338
Gln Val Val Ser Asp Phe Gly Lys Ile Asp Ala Phe Ile Ala Asn Ala
         95                 100                 105
 
ggt gct act gct aat tct ggt gtt gtt gat gga tct gct tct gat tgg   386
Gly Ala Thr Ala Asn Ser Gly Val Val Asp Gly Ser Ala Ser Asp Trp
    110                 115                 120
 
gat cat gtt att caa gtt gat ttg tca gga aca gca tat tgt gca aaa   434
Asp His Val Ile Gln Val Asp Leu Ser Gly Thr Ala Tyr Cys Ala Lys
125                 130                 135                 140
 
gca gtg gga gcc cat ttt aaa aag caa gga cat gga tct tta gtt att   482
Ala Val Gly Ala His Phe Lys Lys Gln Gly His Gly Ser Leu Val Ile
                145                 150                 155
 
act gca tct atg tct gga cac gtt gct aat tat cca caa gaa caa aca   530
Thr Ala Ser Met Ser Gly His Val Ala Asn Tyr Pro Gln Glu Gln Thr
            160                 165                 170
 
tct tat aat gtt gct aaa gct gga tgt att cat ttg gct aga tct tta   578
Ser Tyr Asn Val Ala Lys Ala Gly Cys Ile His Leu Ala Arg Ser Leu
        175                 180                 185
 
gct aat gaa tgg aga gat ttc gct aga gtt aat tct att tca cct ggt   626
Ala Asn Glu Trp Arg Asp Phe Ala Arg Val Asn Ser Ile Ser Pro Gly
    190                 195                 200
 
tat att gat act gga ttg tct gat ttt att gat gaa aag act caa gaa   674
Tyr Ile Asp Thr Gly Leu Ser Asp Phe Ile Asp Glu Lys Thr Gln Glu
205                 210                 215                 220
 
ttg tgg aga tct atg att cca atg ggt aga aat gga gat gct aaa gaa   722
Leu Trp Arg Ser Met Ile Pro Met Gly Arg Asn Gly Asp Ala Lys Glu
                225                 230                 235
 
tta aaa gga gct tat gtt tat ttg gtt tct gat gct tct tct tat act   770
Leu Lys Gly Ala Tyr Val Tyr Leu Val Ser Asp Ala Ser Ser Tyr Thr
            240                 245                 250
 
act gga gct gat ata gtt att gat gga gga tat act act aga           812
Thr Gly Ala Asp Ile Val Ile Asp Gly Gly Tyr Thr Thr Arg
        255                 260                 265
 
actagtcgat gcct                                                   826

<210> 162
<211> 266
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in P. pastoris

<400> 162
Met Pro Gln Pro Val Pro Thr Ala Asn Arg Leu Leu Asp Leu Phe Ser
 1               5                  10                  15      
Leu Lys Gly Lys Val Val Val Val Thr Gly Ala Ser Gly Pro Arg Gly
            20                  25                  30          
Met Gly Ile Glu Ala Ala Arg Gly Cys Ala Glu Met Gly Ala Asp Leu
        35                  40                  45              
Ala Ile Thr Tyr Ser Ser Arg Lys Glu Gly Ala Glu Lys Asn Ala Glu
    50                  55                  60                  
Glu Leu Thr Lys Glu Tyr Gly Val Lys Val Lys Val Tyr Lys Val Asn
65                  70                  75                  80  
Gln Ser Asp Tyr Asn Asp Val Glu Arg Phe Val Asn Gln Val Val Ser
                85                  90                  95      
Asp Phe Gly Lys Ile Asp Ala Phe Ile Ala Asn Ala Gly Ala Thr Ala
            100                 105                 110         
Asn Ser Gly Val Val Asp Gly Ser Ala Ser Asp Trp Asp His Val Ile
        115                 120                 125             
Gln Val Asp Leu Ser Gly Thr Ala Tyr Cys Ala Lys Ala Val Gly Ala
    130                 135                 140                 
His Phe Lys Lys Gln Gly His Gly Ser Leu Val Ile Thr Ala Ser Met
145                 150                 155                 160 
Ser Gly His Val Ala Asn Tyr Pro Gln Glu Gln Thr Ser Tyr Asn Val
                165                 170                 175     
Ala Lys Ala Gly Cys Ile His Leu Ala Arg Ser Leu Ala Asn Glu Trp
            180                 185                 190         
Arg Asp Phe Ala Arg Val Asn Ser Ile Ser Pro Gly Tyr Ile Asp Thr
        195                 200                 205             
Gly Leu Ser Asp Phe Ile Asp Glu Lys Thr Gln Glu Leu Trp Arg Ser
    210                 215                 220                 
Met Ile Pro Met Gly Arg Asn Gly Asp Ala Lys Glu Leu Lys Gly Ala
225                 230                 235                 240 
Tyr Val Tyr Leu Val Ser Asp Ala Ser Ser Tyr Thr Thr Gly Ala Asp
                245                 250                 255     
Ile Val Ile Asp Gly Gly Tyr Thr Thr Arg
            260                 265     


<210> 163
<211> 820
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in P. pastoris

<220> 
<221> CDS            
<222> (12)...(809)

<400> 163
tactcaagct t atg cca caa cca gtt cca aca gct aat aga ttg tta gat  50
             Met Pro Gln Pro Val Pro Thr Ala Asn Arg Leu Leu Asp
              1               5                   10
 
ttg ttt tct tta aaa gga aaa gtg gtt gtt gtt act gga gct tct gga   98
Leu Phe Ser Leu Lys Gly Lys Val Val Val Val Thr Gly Ala Ser Gly
     15                  20                  25
 
cct aga gga atg gga att gag gct gct aga gga tgt gct gaa atg ggc   146
Pro Arg Gly Met Gly Ile Glu Ala Ala Arg Gly Cys Ala Glu Met Gly
 30                  35                  40                  45
 
gct gat tta gct att act tat tct tct aga aag gaa gga gct gag aaa   194
Ala Asp Leu Ala Ile Thr Tyr Ser Ser Arg Lys Glu Gly Ala Glu Lys
                 50                  55                  60
 
aat gca gaa gaa ttg act aaa gaa tat gga gtt aaa gtt aaa gtt tat   242
Asn Ala Glu Glu Leu Thr Lys Glu Tyr Gly Val Lys Val Lys Val Tyr
             65                  70                  75
 
aaa gtt aat caa tct gat tat aat gat gtt gaa aga ttt gtt aat caa   290
Lys Val Asn Gln Ser Asp Tyr Asn Asp Val Glu Arg Phe Val Asn Gln
         80                  85                  90
 
gtt gtt tct gat ttt ggt aaa att gat gct ttt att gct aac gct ggt   338
Val Val Ser Asp Phe Gly Lys Ile Asp Ala Phe Ile Ala Asn Ala Gly
     95                 100                 105
 
gct act gct aat tct ggt gtt gtt gat gga tct gct tct gat tgg gat   386
Ala Thr Ala Asn Ser Gly Val Val Asp Gly Ser Ala Ser Asp Trp Asp
110                 115                 120                 125
 
cat gtt att caa gtt gat ttg tca gga aca gca tat tgt gca aaa gca   434
His Val Ile Gln Val Asp Leu Ser Gly Thr Ala Tyr Cys Ala Lys Ala
                130                 135                 140
 
gtg gga gcc cat ttt aaa aag caa gga cat gga tct tta gtt att act   482
Val Gly Ala His Phe Lys Lys Gln Gly His Gly Ser Leu Val Ile Thr
            145                 150                 155
 
gca tct atg tct gga cac gtt gct aat tat cca caa gaa caa aca tct   530
Ala Ser Met Ser Gly His Val Ala Asn Tyr Pro Gln Glu Gln Thr Ser
        160                 165                 170
 
tat aat gtt gct aaa gct gga tgt att cat ttg gct aga tct tta gct   578
Tyr Asn Val Ala Lys Ala Gly Cys Ile His Leu Ala Arg Ser Leu Ala
    175                 180                 185
 
aat gaa tgg aga gat ttc gct aga gtt aat tct att tca cct ggt tat   626
Asn Glu Trp Arg Asp Phe Ala Arg Val Asn Ser Ile Ser Pro Gly Tyr
190                 195                 200                 205
 
att gat act gga ttg tct gat ttt att gat gaa aag act caa gaa ttg   674
Ile Asp Thr Gly Leu Ser Asp Phe Ile Asp Glu Lys Thr Gln Glu Leu
                210                 215                 220
 
tgg aga tct atg att cca atg ggt aga aat gga gat gct aaa gaa tta   722
Trp Arg Ser Met Ile Pro Met Gly Arg Asn Gly Asp Ala Lys Glu Leu
            225                 230                 235
 
aaa gga gct tat gtt tat ttg gtt tct gat gct tct tct tat act act   770
Lys Gly Ala Tyr Val Tyr Leu Val Ser Asp Ala Ser Ser Tyr Thr Thr
        240                 245                 250
 
gga gct gat ata gtt att gat gga gga tat act act aga gaattccgat    819
Gly Ala Asp Ile Val Ile Asp Gly Gly Tyr Thr Thr Arg
    255                 260                 265
 
g                                                                 820

<210> 164
<211> 266
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in P. pastoris

<400> 164
Met Pro Gln Pro Val Pro Thr Ala Asn Arg Leu Leu Asp Leu Phe Ser
 1               5                  10                  15      
Leu Lys Gly Lys Val Val Val Val Thr Gly Ala Ser Gly Pro Arg Gly
            20                  25                  30          
Met Gly Ile Glu Ala Ala Arg Gly Cys Ala Glu Met Gly Ala Asp Leu
        35                  40                  45              
Ala Ile Thr Tyr Ser Ser Arg Lys Glu Gly Ala Glu Lys Asn Ala Glu
    50                  55                  60                  
Glu Leu Thr Lys Glu Tyr Gly Val Lys Val Lys Val Tyr Lys Val Asn
65                  70                  75                  80  
Gln Ser Asp Tyr Asn Asp Val Glu Arg Phe Val Asn Gln Val Val Ser
                85                  90                  95      
Asp Phe Gly Lys Ile Asp Ala Phe Ile Ala Asn Ala Gly Ala Thr Ala
            100                 105                 110         
Asn Ser Gly Val Val Asp Gly Ser Ala Ser Asp Trp Asp His Val Ile
        115                 120                 125             
Gln Val Asp Leu Ser Gly Thr Ala Tyr Cys Ala Lys Ala Val Gly Ala
    130                 135                 140                 
His Phe Lys Lys Gln Gly His Gly Ser Leu Val Ile Thr Ala Ser Met
145                 150                 155                 160 
Ser Gly His Val Ala Asn Tyr Pro Gln Glu Gln Thr Ser Tyr Asn Val
                165                 170                 175     
Ala Lys Ala Gly Cys Ile His Leu Ala Arg Ser Leu Ala Asn Glu Trp
            180                 185                 190         
Arg Asp Phe Ala Arg Val Asn Ser Ile Ser Pro Gly Tyr Ile Asp Thr
        195                 200                 205             
Gly Leu Ser Asp Phe Ile Asp Glu Lys Thr Gln Glu Leu Trp Arg Ser
    210                 215                 220                 
Met Ile Pro Met Gly Arg Asn Gly Asp Ala Lys Glu Leu Lys Gly Ala
225                 230                 235                 240 
Tyr Val Tyr Leu Val Ser Asp Ala Ser Ser Tyr Thr Thr Gly Ala Asp
                245                 250                 255     
Ile Val Ile Asp Gly Gly Tyr Thr Thr Arg
            260                 265     


<210> 165
<211> 798
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in K. lactis

<220> 
<221> CDS            
<222> (1)...(798)

<400> 165
atg cca caa cca gtt cca act gct aat aga ttg ttg gat ttg ttc tct   48
Met Pro Gln Pro Val Pro Thr Ala Asn Arg Leu Leu Asp Leu Phe Ser
 1               5                   10                  15
 
tta aag gga aaa gtt gtt gtt gtt act ggt gct tct ggt cct aga ggt   96
Leu Lys Gly Lys Val Val Val Val Thr Gly Ala Ser Gly Pro Arg Gly
             20                  25                  30
 
atg gga att gaa gct gct aga ggt tgt gct gaa atg ggt gct gat ttg   144
Met Gly Ile Glu Ala Ala Arg Gly Cys Ala Glu Met Gly Ala Asp Leu
         35                  40                  45
 
gct att act tat tct tct agg aag gaa ggt gca gaa aag aat gcc gaa   192
Ala Ile Thr Tyr Ser Ser Arg Lys Glu Gly Ala Glu Lys Asn Ala Glu
     50                  55                  60
 
gaa ttg act aaa gaa tat ggt gtt aaa gtt aaa gtt tat aaa gtt aat   240
Glu Leu Thr Lys Glu Tyr Gly Val Lys Val Lys Val Tyr Lys Val Asn
 65                  70                  75                  80
 
caa tct gat tat aat gat gtt gaa aga ttc gtt aat caa gtt gtt tct   288
Gln Ser Asp Tyr Asn Asp Val Glu Arg Phe Val Asn Gln Val Val Ser
                 85                  90                  95
 
gat ttc gga aaa att gat gct ttc att gct aat gct ggc gca act gca   336
Asp Phe Gly Lys Ile Asp Ala Phe Ile Ala Asn Ala Gly Ala Thr Ala
            100                 105                 110
 
aac tct ggt gtt gtt gac gga tct gct agt gat tgg gat cat gtt att   384
Asn Ser Gly Val Val Asp Gly Ser Ala Ser Asp Trp Asp His Val Ile
        115                 120                 125
 
cag gtt gat ttg tct ggt aca gct tat tgt gct aaa gcc gtt ggt gca   432
Gln Val Asp Leu Ser Gly Thr Ala Tyr Cys Ala Lys Ala Val Gly Ala
    130                 135                 140
 
cat ttt aaa aag caa ggt cat ggt tca ttg gtt att act gct tct atg   480
His Phe Lys Lys Gln Gly His Gly Ser Leu Val Ile Thr Ala Ser Met
145                 150                 155                 160
 
tca gga cat gtt gct aat tat cca caa gaa caa act tct tat aat gtt   528
Ser Gly His Val Ala Asn Tyr Pro Gln Glu Gln Thr Ser Tyr Asn Val
                165                 170                 175
 
gcc aaa gcg gga tgt att cat ttg gct aga tct tta gct aat gaa tgg   576
Ala Lys Ala Gly Cys Ile His Leu Ala Arg Ser Leu Ala Asn Glu Trp
            180                 185                 190
 
aga gat ttc gct aga gtt aat tct att tca cca ggt tat att gat act   624
Arg Asp Phe Ala Arg Val Asn Ser Ile Ser Pro Gly Tyr Ile Asp Thr
        195                 200                 205
 
ggt ttg tct gat ttc att gat gag aag act caa gaa ttg tgg aga tct   672
Gly Leu Ser Asp Phe Ile Asp Glu Lys Thr Gln Glu Leu Trp Arg Ser
    210                 215                 220
 
atg att cca atg ggt aga aat ggt gat gct aaa gaa tta aag gga gca   720
Met Ile Pro Met Gly Arg Asn Gly Asp Ala Lys Glu Leu Lys Gly Ala
225                 230                 235                 240
 
tac gtt tat tta gtt tct gat gct agc tct tat act act ggg gca gac   768
Tyr Val Tyr Leu Val Ser Asp Ala Ser Ser Tyr Thr Thr Gly Ala Asp
                245                 250                 255
 
att gtt att gat ggt ggt tat act act aga                           798
Ile Val Ile Asp Gly Gly Tyr Thr Thr Arg
            260                 265
 

<210> 166
<211> 266
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in K. lactis

<400> 166
Met Pro Gln Pro Val Pro Thr Ala Asn Arg Leu Leu Asp Leu Phe Ser
 1               5                  10                  15      
Leu Lys Gly Lys Val Val Val Val Thr Gly Ala Ser Gly Pro Arg Gly
            20                  25                  30          
Met Gly Ile Glu Ala Ala Arg Gly Cys Ala Glu Met Gly Ala Asp Leu
        35                  40                  45              
Ala Ile Thr Tyr Ser Ser Arg Lys Glu Gly Ala Glu Lys Asn Ala Glu
    50                  55                  60                  
Glu Leu Thr Lys Glu Tyr Gly Val Lys Val Lys Val Tyr Lys Val Asn
65                  70                  75                  80  
Gln Ser Asp Tyr Asn Asp Val Glu Arg Phe Val Asn Gln Val Val Ser
                85                  90                  95      
Asp Phe Gly Lys Ile Asp Ala Phe Ile Ala Asn Ala Gly Ala Thr Ala
            100                 105                 110         
Asn Ser Gly Val Val Asp Gly Ser Ala Ser Asp Trp Asp His Val Ile
        115                 120                 125             
Gln Val Asp Leu Ser Gly Thr Ala Tyr Cys Ala Lys Ala Val Gly Ala
    130                 135                 140                 
His Phe Lys Lys Gln Gly His Gly Ser Leu Val Ile Thr Ala Ser Met
145                 150                 155                 160 
Ser Gly His Val Ala Asn Tyr Pro Gln Glu Gln Thr Ser Tyr Asn Val
                165                 170                 175     
Ala Lys Ala Gly Cys Ile His Leu Ala Arg Ser Leu Ala Asn Glu Trp
            180                 185                 190         
Arg Asp Phe Ala Arg Val Asn Ser Ile Ser Pro Gly Tyr Ile Asp Thr
        195                 200                 205             
Gly Leu Ser Asp Phe Ile Asp Glu Lys Thr Gln Glu Leu Trp Arg Ser
    210                 215                 220                 
Met Ile Pro Met Gly Arg Asn Gly Asp Ala Lys Glu Leu Lys Gly Ala
225                 230                 235                 240 
Tyr Val Tyr Leu Val Ser Asp Ala Ser Ser Tyr Thr Thr Gly Ala Asp
                245                 250                 255     
Ile Val Ile Asp Gly Gly Tyr Thr Thr Arg
            260                 265     


<210> 167
<211> 798
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in Z. mobilis

<220> 
<221> CDS            
<222> (1)...(798)

<400> 167
atg ccg cag ccg gtt ccg aca gct aat cgt ttg ttg gat ttg ttt tct   48
Met Pro Gln Pro Val Pro Thr Ala Asn Arg Leu Leu Asp Leu Phe Ser
 1               5                   10                  15
 
ttg aaa ggt aaa gtt gtt gtt gtt acc ggt gcc tct ggt ccg cgt ggc   96
Leu Lys Gly Lys Val Val Val Val Thr Gly Ala Ser Gly Pro Arg Gly
             20                  25                  30
 
atg ggc att gag gct gcc aga ggt tgt gcc gaa atg ggt gcc gat ttg   144
Met Gly Ile Glu Ala Ala Arg Gly Cys Ala Glu Met Gly Ala Asp Leu
         35                  40                  45
 
gcc att acg tat tct tct cgt aaa gaa ggt gcg gag aaa aat gcc gaa   192
Ala Ile Thr Tyr Ser Ser Arg Lys Glu Gly Ala Glu Lys Asn Ala Glu
     50                  55                  60
 
gaa ttg acc aaa gaa tat ggt gtt aaa gtt aaa gtt tat aaa gtt aat   240
Glu Leu Thr Lys Glu Tyr Gly Val Lys Val Lys Val Tyr Lys Val Asn
 65                  70                  75                  80
 
cag tct gat tat aat gat gtt gaa cgt ttt gtt aat cag gtt gtt tct   288
Gln Ser Asp Tyr Asn Asp Val Glu Arg Phe Val Asn Gln Val Val Ser
                 85                  90                  95
 
gat ttt ggt aaa att gat gct ttc att gct aat gct gga gcg acg gca   336
Asp Phe Gly Lys Ile Asp Ala Phe Ile Ala Asn Ala Gly Ala Thr Ala
            100                 105                 110
 
aat agc ggt gtt gtt gat ggt tct gct agt gac tgg gat cat gtc att   384
Asn Ser Gly Val Val Asp Gly Ser Ala Ser Asp Trp Asp His Val Ile
        115                 120                 125
 
cag gtc gac ttg tct gga acc gct tat tgt gcc aaa gcc gtt ggt gca   432
Gln Val Asp Leu Ser Gly Thr Ala Tyr Cys Ala Lys Ala Val Gly Ala
    130                 135                 140
 
cat ttt aaa aag cag ggt cat ggt tct ttg gtg att acc gcc tct atg   480
His Phe Lys Lys Gln Gly His Gly Ser Leu Val Ile Thr Ala Ser Met
145                 150                 155                 160
 
tct ggt cat gtt gct aat tat ccg caa gaa cag acc tct tat aat gtt   528
Ser Gly His Val Ala Asn Tyr Pro Gln Glu Gln Thr Ser Tyr Asn Val
                165                 170                 175
 
gct aag gcc ggg tgt att cat ttg gct cgc tct ttg gct aat gaa tgg   576
Ala Lys Ala Gly Cys Ile His Leu Ala Arg Ser Leu Ala Asn Glu Trp
            180                 185                 190
 
cgt gat ttt gct cgt gtt aat tct att tct ccg gga tat att gat acc   624
Arg Asp Phe Ala Arg Val Asn Ser Ile Ser Pro Gly Tyr Ile Asp Thr
        195                 200                 205
 
ggt ttg tct gat ttt att gat gag aaa acc cag gaa ttg tgg cgt tct   672
Gly Leu Ser Asp Phe Ile Asp Glu Lys Thr Gln Glu Leu Trp Arg Ser
    210                 215                 220
 
atg att ccg atg ggt cgt aac ggt gat gct aaa gaa ttg aaa ggt gct   720
Met Ile Pro Met Gly Arg Asn Gly Asp Ala Lys Glu Leu Lys Gly Ala
225                 230                 235                 240
 
tat gtt tat ttg gtt tct gat gct tct tct tat acc acg ggc gca gac   768
Tyr Val Tyr Leu Val Ser Asp Ala Ser Ser Tyr Thr Thr Gly Ala Asp
                245                 250                 255
 
att gtt atc gat gga ggg tat acc acc aga                           798
Ile Val Ile Asp Gly Gly Tyr Thr Thr Arg
            260                 265
 

<210> 168
<211> 266
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in Z. mobilis

<400> 168
Met Pro Gln Pro Val Pro Thr Ala Asn Arg Leu Leu Asp Leu Phe Ser
 1               5                  10                  15      
Leu Lys Gly Lys Val Val Val Val Thr Gly Ala Ser Gly Pro Arg Gly
            20                  25                  30          
Met Gly Ile Glu Ala Ala Arg Gly Cys Ala Glu Met Gly Ala Asp Leu
        35                  40                  45              
Ala Ile Thr Tyr Ser Ser Arg Lys Glu Gly Ala Glu Lys Asn Ala Glu
    50                  55                  60                  
Glu Leu Thr Lys Glu Tyr Gly Val Lys Val Lys Val Tyr Lys Val Asn
65                  70                  75                  80  
Gln Ser Asp Tyr Asn Asp Val Glu Arg Phe Val Asn Gln Val Val Ser
                85                  90                  95      
Asp Phe Gly Lys Ile Asp Ala Phe Ile Ala Asn Ala Gly Ala Thr Ala
            100                 105                 110         
Asn Ser Gly Val Val Asp Gly Ser Ala Ser Asp Trp Asp His Val Ile
        115                 120                 125             
Gln Val Asp Leu Ser Gly Thr Ala Tyr Cys Ala Lys Ala Val Gly Ala
    130                 135                 140                 
His Phe Lys Lys Gln Gly His Gly Ser Leu Val Ile Thr Ala Ser Met
145                 150                 155                 160 
Ser Gly His Val Ala Asn Tyr Pro Gln Glu Gln Thr Ser Tyr Asn Val
                165                 170                 175     
Ala Lys Ala Gly Cys Ile His Leu Ala Arg Ser Leu Ala Asn Glu Trp
            180                 185                 190         
Arg Asp Phe Ala Arg Val Asn Ser Ile Ser Pro Gly Tyr Ile Asp Thr
        195                 200                 205             
Gly Leu Ser Asp Phe Ile Asp Glu Lys Thr Gln Glu Leu Trp Arg Ser
    210                 215                 220                 
Met Ile Pro Met Gly Arg Asn Gly Asp Ala Lys Glu Leu Lys Gly Ala
225                 230                 235                 240 
Tyr Val Tyr Leu Val Ser Asp Ala Ser Ser Tyr Thr Thr Gly Ala Asp
                245                 250                 255     
Ile Val Ile Asp Gly Gly Tyr Thr Thr Arg
            260                 265     


<210> 169
<211> 1323
<212> DNA
<213> E. coli

<220> 
<221> CDS            
<222> (1)...(1323)

<400> 169
atg caa gcc tat ttt gac cag ctc gat cgc gtt cgt tat gaa ggc tca   48
Met Gln Ala Tyr Phe Asp Gln Leu Asp Arg Val Arg Tyr Glu Gly Ser
 1               5                   10                  15
 
aaa tcc tca aac ccg tta gca ttc cgt cac tac aat ccc gac gaa ctg   96
Lys Ser Ser Asn Pro Leu Ala Phe Arg His Tyr Asn Pro Asp Glu Leu
             20                  25                  30
 
gtg ttg ggt aag cgt atg gaa gag cac ttg cgt ttt gcc gcc tgc tac   144
Val Leu Gly Lys Arg Met Glu Glu His Leu Arg Phe Ala Ala Cys Tyr
         35                  40                  45
 
tgg cac acc ttc tgc tgg aac ggg gcg gat atg ttt ggt gtg ggg gcg   192
Trp His Thr Phe Cys Trp Asn Gly Ala Asp Met Phe Gly Val Gly Ala
     50                  55                  60
 
ttt aat cgt ccg tgg cag cag cct ggt gag gca ctg gcg ttg gcg aag   240
Phe Asn Arg Pro Trp Gln Gln Pro Gly Glu Ala Leu Ala Leu Ala Lys
 65                  70                  75                  80
 
cgt aaa gca gat gtc gca ttt gag ttt ttc cac aag tta cat gtg cca   288
Arg Lys Ala Asp Val Ala Phe Glu Phe Phe His Lys Leu His Val Pro
                 85                  90                  95
 
ttt tat tgc ttc cac gat gtg gat gtt tcc cct gag ggc gcg tcg tta   336
Phe Tyr Cys Phe His Asp Val Asp Val Ser Pro Glu Gly Ala Ser Leu
            100                 105                 110
 
aaa gag tac atc aat aat ttt gcg caa atg gtt gat gtc ctg gca ggc   384
Lys Glu Tyr Ile Asn Asn Phe Ala Gln Met Val Asp Val Leu Ala Gly
        115                 120                 125
 
aag caa gaa gag agc ggc gtg aag ctg ctg tgg gga acg gcc aac tgc   432
Lys Gln Glu Glu Ser Gly Val Lys Leu Leu Trp Gly Thr Ala Asn Cys
    130                 135                 140
 
ttt aca aac cct cgc tac ggc gcg ggt gcg gcg acg aac cca gat cct   480
Phe Thr Asn Pro Arg Tyr Gly Ala Gly Ala Ala Thr Asn Pro Asp Pro
145                 150                 155                 160
 
gaa gtc ttc agc tgg gcg gca acg caa gtt gtt aca gcg atg gaa gca   528
Glu Val Phe Ser Trp Ala Ala Thr Gln Val Val Thr Ala Met Glu Ala
                165                 170                 175
 
acc cat aaa ttg ggc ggt gaa aac tat gtc ctg tgg ggc ggt cgt gaa   576
Thr His Lys Leu Gly Gly Glu Asn Tyr Val Leu Trp Gly Gly Arg Glu
            180                 185                 190
 
ggt tac gaa acg ctg tta aat acc gac ttg cgt cag gag cgt gaa caa   624
Gly Tyr Glu Thr Leu Leu Asn Thr Asp Leu Arg Gln Glu Arg Glu Gln
        195                 200                 205
 
ctg ggc cgc ttt atg cag atg gtg gtt gag cat aaa cat aaa atc ggt   672
Leu Gly Arg Phe Met Gln Met Val Val Glu His Lys His Lys Ile Gly
    210                 215                 220
 
ttc cag ggc acg ttg ctt atc gaa ccg aaa ccg caa gaa ccg acc aaa   720
Phe Gln Gly Thr Leu Leu Ile Glu Pro Lys Pro Gln Glu Pro Thr Lys
225                 230                 235                 240
 
cat caa tat gat tac gat gcc gcg acg gtc tat ggc ttc ctg aaa cag   768
His Gln Tyr Asp Tyr Asp Ala Ala Thr Val Tyr Gly Phe Leu Lys Gln
                245                 250                 255
 
ttt ggt ctg gaa aaa gag att aaa ctg aac att gaa gct aac cac gcg   816
Phe Gly Leu Glu Lys Glu Ile Lys Leu Asn Ile Glu Ala Asn His Ala
            260                 265                 270
 
acg ctg gca ggt cac tct ttc cat cat gaa ata gcc acc gcc att gcg   864
Thr Leu Ala Gly His Ser Phe His His Glu Ile Ala Thr Ala Ile Ala
        275                 280                 285
 
ctt ggc ctg ttc ggt tct gtc gac gcc aac cgt ggc gat gcg caa ctg   912
Leu Gly Leu Phe Gly Ser Val Asp Ala Asn Arg Gly Asp Ala Gln Leu
    290                 295                 300
 
ggc tgg gac acc gac cag ttc ccg aac agt gtg gaa gag aat gcg ctg   960
Gly Trp Asp Thr Asp Gln Phe Pro Asn Ser Val Glu Glu Asn Ala Leu
305                 310                 315                 320
 
gtg atg tat gaa att ctc aaa gca ggc ggt ttc acc acc ggt ggt ctg   1008
Val Met Tyr Glu Ile Leu Lys Ala Gly Gly Phe Thr Thr Gly Gly Leu
                325                 330                 335
 
aac ttc gat gcc aaa gta cgt cgt caa agt act gat aaa tat gat ctg   1056
Asn Phe Asp Ala Lys Val Arg Arg Gln Ser Thr Asp Lys Tyr Asp Leu
            340                 345                 350
 
ttt tac ggt cat atc ggc gcg atg gat acg atg gca ctg gcg ctg aaa   1104
Phe Tyr Gly His Ile Gly Ala Met Asp Thr Met Ala Leu Ala Leu Lys
        355                 360                 365
 
att gca gcg cgc atg att gaa gat ggc gag ctg gat aaa cgc atc gcg   1152
Ile Ala Ala Arg Met Ile Glu Asp Gly Glu Leu Asp Lys Arg Ile Ala
    370                 375                 380
 
cag cgt tat tcc ggc tgg aat agc gaa ttg ggc cag caa atc ctg aaa   1200
Gln Arg Tyr Ser Gly Trp Asn Ser Glu Leu Gly Gln Gln Ile Leu Lys
385                 390                 395                 400
 
ggc caa atg tca ctg gca gat tta gcc aaa tat gct cag gaa cat cat   1248
Gly Gln Met Ser Leu Ala Asp Leu Ala Lys Tyr Ala Gln Glu His His
                405                 410                 415
 
ttg tct ccg gtg cat cag agt ggt cgc cag gaa caa ctg gaa aat ctg   1296
Leu Ser Pro Val His Gln Ser Gly Arg Gln Glu Gln Leu Glu Asn Leu
            420                 425                 430
 
gta aac cat tat ctg ttc gac aaa taa                               1323
Val Asn His Tyr Leu Phe Asp Lys  *
        435                 440
 

<210> 170
<211> 440
<212> PRT
<213> E. coli

<400> 170
Met Gln Ala Tyr Phe Asp Gln Leu Asp Arg Val Arg Tyr Glu Gly Ser
 1               5                  10                  15      
Lys Ser Ser Asn Pro Leu Ala Phe Arg His Tyr Asn Pro Asp Glu Leu
            20                  25                  30          
Val Leu Gly Lys Arg Met Glu Glu His Leu Arg Phe Ala Ala Cys Tyr
        35                  40                  45              
Trp His Thr Phe Cys Trp Asn Gly Ala Asp Met Phe Gly Val Gly Ala
    50                  55                  60                  
Phe Asn Arg Pro Trp Gln Gln Pro Gly Glu Ala Leu Ala Leu Ala Lys
65                  70                  75                  80  
Arg Lys Ala Asp Val Ala Phe Glu Phe Phe His Lys Leu His Val Pro
                85                  90                  95      
Phe Tyr Cys Phe His Asp Val Asp Val Ser Pro Glu Gly Ala Ser Leu
            100                 105                 110         
Lys Glu Tyr Ile Asn Asn Phe Ala Gln Met Val Asp Val Leu Ala Gly
        115                 120                 125             
Lys Gln Glu Glu Ser Gly Val Lys Leu Leu Trp Gly Thr Ala Asn Cys
    130                 135                 140                 
Phe Thr Asn Pro Arg Tyr Gly Ala Gly Ala Ala Thr Asn Pro Asp Pro
145                 150                 155                 160 
Glu Val Phe Ser Trp Ala Ala Thr Gln Val Val Thr Ala Met Glu Ala
                165                 170                 175     
Thr His Lys Leu Gly Gly Glu Asn Tyr Val Leu Trp Gly Gly Arg Glu
            180                 185                 190         
Gly Tyr Glu Thr Leu Leu Asn Thr Asp Leu Arg Gln Glu Arg Glu Gln
        195                 200                 205             
Leu Gly Arg Phe Met Gln Met Val Val Glu His Lys His Lys Ile Gly
    210                 215                 220                 
Phe Gln Gly Thr Leu Leu Ile Glu Pro Lys Pro Gln Glu Pro Thr Lys
225                 230                 235                 240 
His Gln Tyr Asp Tyr Asp Ala Ala Thr Val Tyr Gly Phe Leu Lys Gln
                245                 250                 255     
Phe Gly Leu Glu Lys Glu Ile Lys Leu Asn Ile Glu Ala Asn His Ala
            260                 265                 270         
Thr Leu Ala Gly His Ser Phe His His Glu Ile Ala Thr Ala Ile Ala
        275                 280                 285             
Leu Gly Leu Phe Gly Ser Val Asp Ala Asn Arg Gly Asp Ala Gln Leu
    290                 295                 300                 
Gly Trp Asp Thr Asp Gln Phe Pro Asn Ser Val Glu Glu Asn Ala Leu
305                 310                 315                 320 
Val Met Tyr Glu Ile Leu Lys Ala Gly Gly Phe Thr Thr Gly Gly Leu
                325                 330                 335     
Asn Phe Asp Ala Lys Val Arg Arg Gln Ser Thr Asp Lys Tyr Asp Leu
            340                 345                 350         
Phe Tyr Gly His Ile Gly Ala Met Asp Thr Met Ala Leu Ala Leu Lys
        355                 360                 365             
Ile Ala Ala Arg Met Ile Glu Asp Gly Glu Leu Asp Lys Arg Ile Ala
    370                 375                 380                 
Gln Arg Tyr Ser Gly Trp Asn Ser Glu Leu Gly Gln Gln Ile Leu Lys
385                 390                 395                 400 
Gly Gln Met Ser Leu Ala Asp Leu Ala Lys Tyr Ala Gln Glu His His
                405                 410                 415     
Leu Ser Pro Val His Gln Ser Gly Arg Gln Glu Gln Leu Glu Asn Leu
            420                 425                 430         
Val Asn His Tyr Leu Phe Asp Lys
        435                 440 


<210> 171
<211> 1320
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in S. cerevisiae

<220> 
<221> CDS            
<222> (1)...(1320)

<400> 171
atg caa gca tat ttt gat caa ttg gat aga gtt aga tat gaa ggt tct   48
Met Gln Ala Tyr Phe Asp Gln Leu Asp Arg Val Arg Tyr Glu Gly Ser
 1               5                   10                  15
 
aaa tct tct aat cca ttg gct ttt aga cat tat aat cca gat gaa ttg   96
Lys Ser Ser Asn Pro Leu Ala Phe Arg His Tyr Asn Pro Asp Glu Leu
             20                  25                  30
 
gtt ttg ggt aag aga atg gag gaa cat ttg aga ttt gct gct tgt tat   144
Val Leu Gly Lys Arg Met Glu Glu His Leu Arg Phe Ala Ala Cys Tyr
         35                  40                  45
 
tgg cat act ttt tgt tgg aat ggt gct gat atg ttt ggc gta gga gct   192
Trp His Thr Phe Cys Trp Asn Gly Ala Asp Met Phe Gly Val Gly Ala
     50                  55                  60
 
ttt aat aga cca tgg cag caa cca ggt gag gct ttg gct cta gca aaa   240
Phe Asn Arg Pro Trp Gln Gln Pro Gly Glu Ala Leu Ala Leu Ala Lys
 65                  70                  75                  80
 
aga aag gct gat gtt gct ttt gag ttc ttt cat aaa ttg cat gtt cca   288
Arg Lys Ala Asp Val Ala Phe Glu Phe Phe His Lys Leu His Val Pro
                 85                  90                  95
 
ttt tat tgt ttt cat gat gtt gat gta tca cca gaa gga gca tct tta   336
Phe Tyr Cys Phe His Asp Val Asp Val Ser Pro Glu Gly Ala Ser Leu
            100                 105                 110
 
aaa gaa tat att aat aat ttt gct caa atg gtt gat gtt tta gct gga   384
Lys Glu Tyr Ile Asn Asn Phe Ala Gln Met Val Asp Val Leu Ala Gly
        115                 120                 125
 
aaa cag gaa gaa tct ggt gtt aaa ttg tta tgg ggt act gct aat tgt   432
Lys Gln Glu Glu Ser Gly Val Lys Leu Leu Trp Gly Thr Ala Asn Cys
    130                 135                 140
 
ttt act aat cct aga tat ggt gca gga gcc gct aca aat cca gat cca   480
Phe Thr Asn Pro Arg Tyr Gly Ala Gly Ala Ala Thr Asn Pro Asp Pro
145                 150                 155                 160
 
gaa gtt ttt agt tgg gct gct aca caa gta gtt act gct atg gaa gct   528
Glu Val Phe Ser Trp Ala Ala Thr Gln Val Val Thr Ala Met Glu Ala
                165                 170                 175
 
acc cat aaa tta ggt ggt gaa aat tat gtt ttg tgg ggt ggt aga gaa   576
Thr His Lys Leu Gly Gly Glu Asn Tyr Val Leu Trp Gly Gly Arg Glu
            180                 185                 190
 
ggt tat gaa aca ttg tta aat act gat ttg aga caa gaa aga gaa caa   624
Gly Tyr Glu Thr Leu Leu Asn Thr Asp Leu Arg Gln Glu Arg Glu Gln
        195                 200                 205
 
ttg ggt aga ttt atg caa atg gtt gtt gaa cat aaa cat aaa att ggt   672
Leu Gly Arg Phe Met Gln Met Val Val Glu His Lys His Lys Ile Gly
    210                 215                 220
 
ttt caa ggt aca ttg ttg att gaa cca aaa cca caa gaa cca act aaa   720
Phe Gln Gly Thr Leu Leu Ile Glu Pro Lys Pro Gln Glu Pro Thr Lys
225                 230                 235                 240
 
cat caa tat gat tat gat gct gct aca gtt tat ggt ttt cta aaa caa   768
His Gln Tyr Asp Tyr Asp Ala Ala Thr Val Tyr Gly Phe Leu Lys Gln
                245                 250                 255
 
ttt gga tta gaa aaa gaa att aaa tta aac att gaa gct aat cat gct   816
Phe Gly Leu Glu Lys Glu Ile Lys Leu Asn Ile Glu Ala Asn His Ala
            260                 265                 270
 
aca ttg gct ggt cat tct ttt cat cat gaa att gca act gct ata gct   864
Thr Leu Ala Gly His Ser Phe His His Glu Ile Ala Thr Ala Ile Ala
        275                 280                 285
 
tta ggt ttg ttc ggt tct gtt gat gct aat aga ggt gat gct caa ttg   912
Leu Gly Leu Phe Gly Ser Val Asp Ala Asn Arg Gly Asp Ala Gln Leu
    290                 295                 300
 
ggt tgg gat act gat caa ttt cca aat tct gtt gaa gaa aat gct ttg   960
Gly Trp Asp Thr Asp Gln Phe Pro Asn Ser Val Glu Glu Asn Ala Leu
305                 310                 315                 320
 
gtt atg tat gaa att tta aaa gct ggt ggt ttt act act ggt ggt tta   1008
Val Met Tyr Glu Ile Leu Lys Ala Gly Gly Phe Thr Thr Gly Gly Leu
                325                 330                 335
 
aat ttt gat gct aaa gta agg aga caa tct aca gat aaa tat gat ttg   1056
Asn Phe Asp Ala Lys Val Arg Arg Gln Ser Thr Asp Lys Tyr Asp Leu
            340                 345                 350
 
ttt tat ggt cat att ggt gct atg gat act atg gca ttg gca tta aaa   1104
Phe Tyr Gly His Ile Gly Ala Met Asp Thr Met Ala Leu Ala Leu Lys
        355                 360                 365
 
att gct gct aga atg att gaa gat ggt gaa ttg gat aaa aga att gct   1152
Ile Ala Ala Arg Met Ile Glu Asp Gly Glu Leu Asp Lys Arg Ile Ala
    370                 375                 380
 
caa aga tat tct ggt tgg aat agt gag ttg ggt caa caa att tta aag   1200
Gln Arg Tyr Ser Gly Trp Asn Ser Glu Leu Gly Gln Gln Ile Leu Lys
385                 390                 395                 400
 
ggt caa atg tct ttg gct gat ttg gct aaa tat gct caa gaa cat cat   1248
Gly Gln Met Ser Leu Ala Asp Leu Ala Lys Tyr Ala Gln Glu His His
                405                 410                 415
 
ttg tca cca gtt cat caa tca ggt aga caa gaa caa ttg gaa aat ttg   1296
Leu Ser Pro Val His Gln Ser Gly Arg Gln Glu Gln Leu Glu Asn Leu
            420                 425                 430
 
gtt aat cat tat ttg ttc gat aaa                                   1320
Val Asn His Tyr Leu Phe Asp Lys
        435                 440
 

<210> 172
<211> 440
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in S. cerevisiae

<400> 172
Met Gln Ala Tyr Phe Asp Gln Leu Asp Arg Val Arg Tyr Glu Gly Ser
 1               5                  10                  15      
Lys Ser Ser Asn Pro Leu Ala Phe Arg His Tyr Asn Pro Asp Glu Leu
            20                  25                  30          
Val Leu Gly Lys Arg Met Glu Glu His Leu Arg Phe Ala Ala Cys Tyr
        35                  40                  45              
Trp His Thr Phe Cys Trp Asn Gly Ala Asp Met Phe Gly Val Gly Ala
    50                  55                  60                  
Phe Asn Arg Pro Trp Gln Gln Pro Gly Glu Ala Leu Ala Leu Ala Lys
65                  70                  75                  80  
Arg Lys Ala Asp Val Ala Phe Glu Phe Phe His Lys Leu His Val Pro
                85                  90                  95      
Phe Tyr Cys Phe His Asp Val Asp Val Ser Pro Glu Gly Ala Ser Leu
            100                 105                 110         
Lys Glu Tyr Ile Asn Asn Phe Ala Gln Met Val Asp Val Leu Ala Gly
        115                 120                 125             
Lys Gln Glu Glu Ser Gly Val Lys Leu Leu Trp Gly Thr Ala Asn Cys
    130                 135                 140                 
Phe Thr Asn Pro Arg Tyr Gly Ala Gly Ala Ala Thr Asn Pro Asp Pro
145                 150                 155                 160 
Glu Val Phe Ser Trp Ala Ala Thr Gln Val Val Thr Ala Met Glu Ala
                165                 170                 175     
Thr His Lys Leu Gly Gly Glu Asn Tyr Val Leu Trp Gly Gly Arg Glu
            180                 185                 190         
Gly Tyr Glu Thr Leu Leu Asn Thr Asp Leu Arg Gln Glu Arg Glu Gln
        195                 200                 205             
Leu Gly Arg Phe Met Gln Met Val Val Glu His Lys His Lys Ile Gly
    210                 215                 220                 
Phe Gln Gly Thr Leu Leu Ile Glu Pro Lys Pro Gln Glu Pro Thr Lys
225                 230                 235                 240 
His Gln Tyr Asp Tyr Asp Ala Ala Thr Val Tyr Gly Phe Leu Lys Gln
                245                 250                 255     
Phe Gly Leu Glu Lys Glu Ile Lys Leu Asn Ile Glu Ala Asn His Ala
            260                 265                 270         
Thr Leu Ala Gly His Ser Phe His His Glu Ile Ala Thr Ala Ile Ala
        275                 280                 285             
Leu Gly Leu Phe Gly Ser Val Asp Ala Asn Arg Gly Asp Ala Gln Leu
    290                 295                 300                 
Gly Trp Asp Thr Asp Gln Phe Pro Asn Ser Val Glu Glu Asn Ala Leu
305                 310                 315                 320 
Val Met Tyr Glu Ile Leu Lys Ala Gly Gly Phe Thr Thr Gly Gly Leu
                325                 330                 335     
Asn Phe Asp Ala Lys Val Arg Arg Gln Ser Thr Asp Lys Tyr Asp Leu
            340                 345                 350         
Phe Tyr Gly His Ile Gly Ala Met Asp Thr Met Ala Leu Ala Leu Lys
        355                 360                 365             
Ile Ala Ala Arg Met Ile Glu Asp Gly Glu Leu Asp Lys Arg Ile Ala
    370                 375                 380                 
Gln Arg Tyr Ser Gly Trp Asn Ser Glu Leu Gly Gln Gln Ile Leu Lys
385                 390                 395                 400 
Gly Gln Met Ser Leu Ala Asp Leu Ala Lys Tyr Ala Gln Glu His His
                405                 410                 415     
Leu Ser Pro Val His Gln Ser Gly Arg Gln Glu Gln Leu Glu Asn Leu
            420                 425                 430         
Val Asn His Tyr Leu Phe Asp Lys
        435                 440 


<210> 173
<211> 1342
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in S. cerevisiae

<220> 
<221> CDS            
<222> (12)...(1331)

<400> 173
tactcaagct t atg caa gca tat ttt gat caa ttg gat aga gtt aga tat  50
             Met Gln Ala Tyr Phe Asp Gln Leu Asp Arg Val Arg Tyr
              1               5                   10
 
gaa ggt tct aaa tct tct aat cca ttg gct ttt aga cat tat aat cca   98
Glu Gly Ser Lys Ser Ser Asn Pro Leu Ala Phe Arg His Tyr Asn Pro
     15                  20                  25
 
gat gaa ttg gtt ttg ggt aag aga atg gag gaa cat ttg aga ttt gct   146
Asp Glu Leu Val Leu Gly Lys Arg Met Glu Glu His Leu Arg Phe Ala
 30                  35                  40                  45
 
gct tgt tat tgg cat act ttt tgt tgg aat ggt gct gat atg ttt ggc   194
Ala Cys Tyr Trp His Thr Phe Cys Trp Asn Gly Ala Asp Met Phe Gly
                 50                  55                  60
 
gta gga gct ttt aat aga cca tgg cag caa cca ggt gag gct ttg gct   242
Val Gly Ala Phe Asn Arg Pro Trp Gln Gln Pro Gly Glu Ala Leu Ala
             65                  70                  75
 
cta gca aaa aga aag gct gat gtt gct ttt gag ttc ttt cat aaa ttg   290
Leu Ala Lys Arg Lys Ala Asp Val Ala Phe Glu Phe Phe His Lys Leu
         80                  85                  90
 
cat gtt cca ttt tat tgt ttt cat gat gtt gat gta tca cca gaa gga   338
His Val Pro Phe Tyr Cys Phe His Asp Val Asp Val Ser Pro Glu Gly
     95                 100                 105
 
gca tct tta aaa gaa tat att aat aat ttt gct caa atg gtt gat gtt   386
Ala Ser Leu Lys Glu Tyr Ile Asn Asn Phe Ala Gln Met Val Asp Val
110                 115                 120                 125
 
tta gct gga aaa cag gaa gaa tct ggt gtt aaa ttg tta tgg ggt act   434
Leu Ala Gly Lys Gln Glu Glu Ser Gly Val Lys Leu Leu Trp Gly Thr
                130                 135                 140
 
gct aat tgt ttt act aat cct aga tat ggt gca gga gcc gct aca aat   482
Ala Asn Cys Phe Thr Asn Pro Arg Tyr Gly Ala Gly Ala Ala Thr Asn
            145                 150                 155
 
cca gat cca gaa gtt ttt agt tgg gct gct aca caa gta gtt act gct   530
Pro Asp Pro Glu Val Phe Ser Trp Ala Ala Thr Gln Val Val Thr Ala
        160                 165                 170
 
atg gaa gct acc cat aaa tta ggt ggt gaa aat tat gtt ttg tgg ggt   578
Met Glu Ala Thr His Lys Leu Gly Gly Glu Asn Tyr Val Leu Trp Gly
    175                 180                 185
 
ggt aga gaa ggt tat gaa aca ttg tta aat act gat ttg aga caa gaa   626
Gly Arg Glu Gly Tyr Glu Thr Leu Leu Asn Thr Asp Leu Arg Gln Glu
190                 195                 200                 205
 
aga gaa caa ttg ggt aga ttt atg caa atg gtt gtt gaa cat aaa cat   674
Arg Glu Gln Leu Gly Arg Phe Met Gln Met Val Val Glu His Lys His
                210                 215                 220
 
aaa att ggt ttt caa ggt aca ttg ttg att gaa cca aaa cca caa gaa   722
Lys Ile Gly Phe Gln Gly Thr Leu Leu Ile Glu Pro Lys Pro Gln Glu
            225                 230                 235
 
cca act aaa cat caa tat gat tat gat gct gct aca gtt tat ggt ttt   770
Pro Thr Lys His Gln Tyr Asp Tyr Asp Ala Ala Thr Val Tyr Gly Phe
        240                 245                 250
 
cta aaa caa ttt gga tta gaa aaa gaa att aaa tta aac att gaa gct   818
Leu Lys Gln Phe Gly Leu Glu Lys Glu Ile Lys Leu Asn Ile Glu Ala
    255                 260                 265
 
aat cat gct aca ttg gct ggt cat tct ttt cat cat gaa att gca act   866
Asn His Ala Thr Leu Ala Gly His Ser Phe His His Glu Ile Ala Thr
270                 275                 280                 285
 
gct ata gct tta ggt ttg ttc ggt tct gtt gat gct aat aga ggt gat   914
Ala Ile Ala Leu Gly Leu Phe Gly Ser Val Asp Ala Asn Arg Gly Asp
                290                 295                 300
 
gct caa ttg ggt tgg gat act gat caa ttt cca aat tct gtt gaa gaa   962
Ala Gln Leu Gly Trp Asp Thr Asp Gln Phe Pro Asn Ser Val Glu Glu
            305                 310                 315
 
aat gct ttg gtt atg tat gaa att tta aaa gct ggt ggt ttt act act   1010
Asn Ala Leu Val Met Tyr Glu Ile Leu Lys Ala Gly Gly Phe Thr Thr
        320                 325                 330
 
ggt ggt tta aat ttt gat gct aaa gta agg aga caa tct aca gat aaa   1058
Gly Gly Leu Asn Phe Asp Ala Lys Val Arg Arg Gln Ser Thr Asp Lys
    335                 340                 345
 
tat gat ttg ttt tat ggt cat att ggt gct atg gat act atg gca ttg   1106
Tyr Asp Leu Phe Tyr Gly His Ile Gly Ala Met Asp Thr Met Ala Leu
350                 355                 360                 365
 
gca tta aaa att gct gct aga atg att gaa gat ggt gaa ttg gat aaa   1154
Ala Leu Lys Ile Ala Ala Arg Met Ile Glu Asp Gly Glu Leu Asp Lys
                370                 375                 380
 
aga att gct caa aga tat tct ggt tgg aat agt gag ttg ggt caa caa   1202
Arg Ile Ala Gln Arg Tyr Ser Gly Trp Asn Ser Glu Leu Gly Gln Gln
            385                 390                 395
 
att tta aag ggt caa atg tct ttg gct gat ttg gct aaa tat gct caa   1250
Ile Leu Lys Gly Gln Met Ser Leu Ala Asp Leu Ala Lys Tyr Ala Gln
        400                 405                 410
 
gaa cat cat ttg tca cca gtt cat caa tca ggt aga caa gaa caa ttg   1298
Glu His His Leu Ser Pro Val His Gln Ser Gly Arg Gln Glu Gln Leu
    415                 420                 425
 
gaa aat ttg gtt aat cat tat ttg ttc gat aaa gaattccgat g          1342
Glu Asn Leu Val Asn His Tyr Leu Phe Asp Lys
430                 435                 440
 

<210> 174
<211> 440
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in S. cerevisiae

<400> 174
Met Gln Ala Tyr Phe Asp Gln Leu Asp Arg Val Arg Tyr Glu Gly Ser
 1               5                  10                  15      
Lys Ser Ser Asn Pro Leu Ala Phe Arg His Tyr Asn Pro Asp Glu Leu
            20                  25                  30          
Val Leu Gly Lys Arg Met Glu Glu His Leu Arg Phe Ala Ala Cys Tyr
        35                  40                  45              
Trp His Thr Phe Cys Trp Asn Gly Ala Asp Met Phe Gly Val Gly Ala
    50                  55                  60                  
Phe Asn Arg Pro Trp Gln Gln Pro Gly Glu Ala Leu Ala Leu Ala Lys
65                  70                  75                  80  
Arg Lys Ala Asp Val Ala Phe Glu Phe Phe His Lys Leu His Val Pro
                85                  90                  95      
Phe Tyr Cys Phe His Asp Val Asp Val Ser Pro Glu Gly Ala Ser Leu
            100                 105                 110         
Lys Glu Tyr Ile Asn Asn Phe Ala Gln Met Val Asp Val Leu Ala Gly
        115                 120                 125             
Lys Gln Glu Glu Ser Gly Val Lys Leu Leu Trp Gly Thr Ala Asn Cys
    130                 135                 140                 
Phe Thr Asn Pro Arg Tyr Gly Ala Gly Ala Ala Thr Asn Pro Asp Pro
145                 150                 155                 160 
Glu Val Phe Ser Trp Ala Ala Thr Gln Val Val Thr Ala Met Glu Ala
                165                 170                 175     
Thr His Lys Leu Gly Gly Glu Asn Tyr Val Leu Trp Gly Gly Arg Glu
            180                 185                 190         
Gly Tyr Glu Thr Leu Leu Asn Thr Asp Leu Arg Gln Glu Arg Glu Gln
        195                 200                 205             
Leu Gly Arg Phe Met Gln Met Val Val Glu His Lys His Lys Ile Gly
    210                 215                 220                 
Phe Gln Gly Thr Leu Leu Ile Glu Pro Lys Pro Gln Glu Pro Thr Lys
225                 230                 235                 240 
His Gln Tyr Asp Tyr Asp Ala Ala Thr Val Tyr Gly Phe Leu Lys Gln
                245                 250                 255     
Phe Gly Leu Glu Lys Glu Ile Lys Leu Asn Ile Glu Ala Asn His Ala
            260                 265                 270         
Thr Leu Ala Gly His Ser Phe His His Glu Ile Ala Thr Ala Ile Ala
        275                 280                 285             
Leu Gly Leu Phe Gly Ser Val Asp Ala Asn Arg Gly Asp Ala Gln Leu
    290                 295                 300                 
Gly Trp Asp Thr Asp Gln Phe Pro Asn Ser Val Glu Glu Asn Ala Leu
305                 310                 315                 320 
Val Met Tyr Glu Ile Leu Lys Ala Gly Gly Phe Thr Thr Gly Gly Leu
                325                 330                 335     
Asn Phe Asp Ala Lys Val Arg Arg Gln Ser Thr Asp Lys Tyr Asp Leu
            340                 345                 350         
Phe Tyr Gly His Ile Gly Ala Met Asp Thr Met Ala Leu Ala Leu Lys
        355                 360                 365             
Ile Ala Ala Arg Met Ile Glu Asp Gly Glu Leu Asp Lys Arg Ile Ala
    370                 375                 380                 
Gln Arg Tyr Ser Gly Trp Asn Ser Glu Leu Gly Gln Gln Ile Leu Lys
385                 390                 395                 400 
Gly Gln Met Ser Leu Ala Asp Leu Ala Lys Tyr Ala Gln Glu His His
                405                 410                 415     
Leu Ser Pro Val His Gln Ser Gly Arg Gln Glu Gln Leu Glu Asn Leu
            420                 425                 430         
Val Asn His Tyr Leu Phe Asp Lys
        435                 440 


<210> 175
<211> 1348
<212> DNA
<213> Artificial Sequence

<220> 
<223>  sequence modified for expression in S. cerevisiae

<220> 
<221> CDS            
<222> (15)...(1334)

<400> 175
gaatactcca tatg atg caa gca tat ttt gat caa ttg gat aga gtt aga   50
                Met Gln Ala Tyr Phe Asp Gln Leu Asp Arg Val Arg
                 1               5                   10
 
tat gaa ggt tct aaa tct tct aat cca ttg gct ttt aga cat tat aat   98
Tyr Glu Gly Ser Lys Ser Ser Asn Pro Leu Ala Phe Arg His Tyr Asn
         15                  20                  25
 
cca gat gaa ttg gtt ttg ggt aag aga atg gag gaa cat ttg aga ttt   146
Pro Asp Glu Leu Val Leu Gly Lys Arg Met Glu Glu His Leu Arg Phe
     30                  35                  40
 
gct gct tgt tat tgg cat act ttt tgt tgg aat ggt gct gat atg ttt   194
Ala Ala Cys Tyr Trp His Thr Phe Cys Trp Asn Gly Ala Asp Met Phe
 45                  50                  55                  60
 
ggc gta gga gct ttt aat aga cca tgg cag caa cca ggt gag gct ttg   242
Gly Val Gly Ala Phe Asn Arg Pro Trp Gln Gln Pro Gly Glu Ala Leu
                 65                  70                  75
 
gct cta gca aaa aga aag gct gat gtt gct ttt gag ttc ttt cat aaa   290
Ala Leu Ala Lys Arg Lys Ala Asp Val Ala Phe Glu Phe Phe His Lys
             80                  85                  90
 
ttg cat gtt cca ttt tat tgt ttt cat gat gtt gat gta tca cca gaa   338
Leu His Val Pro Phe Tyr Cys Phe His Asp Val Asp Val Ser Pro Glu
         95                 100                 105
 
gga gca tct tta aaa gaa tat att aat aat ttt gct caa atg gtt gat   386
Gly Ala Ser Leu Lys Glu Tyr Ile Asn Asn Phe Ala Gln Met Val Asp
    110                 115                 120
 
gtt tta gct gga aaa cag gaa gaa tct ggt gtt aaa ttg tta tgg ggt   434
Val Leu Ala Gly Lys Gln Glu Glu Ser Gly Val Lys Leu Leu Trp Gly
125                 130                 135                 140
 
act gct aat tgt ttt act aat cct aga tat ggt gca gga gcc gct aca   482
Thr Ala Asn Cys Phe Thr Asn Pro Arg Tyr Gly Ala Gly Ala Ala Thr
                145                 150                 155
 
aat cca gat cca gaa gtt ttt agt tgg gct gct aca caa gta gtt act   530
Asn Pro Asp Pro Glu Val Phe Ser Trp Ala Ala Thr Gln Val Val Thr
            160                 165                 170
 
gct atg gaa gct acc cat aaa tta ggt ggt gaa aat tat gtt ttg tgg   578
Ala Met Glu Ala Thr His Lys Leu Gly Gly Glu Asn Tyr Val Leu Trp
        175                 180                 185
 
ggt ggt aga gaa ggt tat gaa aca ttg tta aat act gat ttg aga caa   626
Gly Gly Arg Glu Gly Tyr Glu Thr Leu Leu Asn Thr Asp Leu Arg Gln
    190                 195                 200
 
gaa aga gaa caa ttg ggt aga ttt atg caa atg gtt gtt gaa cat aaa   674
Glu Arg Glu Gln Leu Gly Arg Phe Met Gln Met Val Val Glu His Lys
205                 210                 215                 220
 
cat aaa att ggt ttt caa ggt aca ttg ttg att gaa cca aaa cca caa   722
His Lys Ile Gly Phe Gln Gly Thr Leu Leu Ile Glu Pro Lys Pro Gln
                225                 230                 235
 
gaa cca act aaa cat caa tat gat tat gat gct gct aca gtt tat ggt   770
Glu Pro Thr Lys His Gln Tyr Asp Tyr Asp Ala Ala Thr Val Tyr Gly
            240                 245                 250
 
ttt cta aaa caa ttt gga tta gaa aaa gaa att aaa tta aac att gaa   818
Phe Leu Lys Gln Phe Gly Leu Glu Lys Glu Ile Lys Leu Asn Ile Glu
        255                 260                 265
 
gct aat cat gct aca ttg gct ggt cat tct ttt cat cat gaa att gca   866
Ala Asn His Ala Thr Leu Ala Gly His Ser Phe His His Glu Ile Ala
    270                 275                 280
 
act gct ata gct tta ggt ttg ttc ggt tct gtt gat gct aat aga ggt   914
Thr Ala Ile Ala Leu Gly Leu Phe Gly Ser Val Asp Ala Asn Arg Gly
285                 290                 295                 300
 
gat gct caa ttg ggt tgg gat act gat caa ttt cca aat tct gtt gaa   962
Asp Ala Gln Leu Gly Trp Asp Thr Asp Gln Phe Pro Asn Ser Val Glu
                305                 310                 315
 
gaa aat gct ttg gtt atg tat gaa att tta aaa gct ggt ggt ttt act   1010
Glu Asn Ala Leu Val Met Tyr Glu Ile Leu Lys Ala Gly Gly Phe Thr
            320                 325                 330
 
act ggt ggt tta aat ttt gat gct aaa gta agg aga caa tct aca gat   1058
Thr Gly Gly Leu Asn Phe Asp Ala Lys Val Arg Arg Gln Ser Thr Asp
        335                 340                 345
 
aaa tat gat ttg ttt tat ggt cat att ggt gct atg gat act atg gca   1106
Lys Tyr Asp Leu Phe Tyr Gly His Ile Gly Ala Met Asp Thr Met Ala
    350                 355                 360
 
ttg gca tta aaa att gct gct aga atg att gaa gat ggt gaa ttg gat   1154
Leu Ala Leu Lys Ile Ala Ala Arg Met Ile Glu Asp Gly Glu Leu Asp
365                 370                 375                 380
 
aaa aga att gct caa aga tat tct ggt tgg aat agt gag ttg ggt caa   1202
Lys Arg Ile Ala Gln Arg Tyr Ser Gly Trp Asn Ser Glu Leu Gly Gln
                385                 390                 395
 
caa att tta aag ggt caa atg tct ttg gct gat ttg gct aaa tat gct   1250
Gln Ile Leu Lys Gly Gln Met Ser Leu Ala Asp Leu Ala Lys Tyr Ala
            400                 405                 410
 
caa gaa cat cat ttg tca cca gtt cat caa tca ggt aga caa gaa caa   1298
Gln Glu His His Leu Ser Pro Val His Gln Ser Gly Arg Gln Glu Gln
        415                 420                 425
 
ttg gaa aat ttg gtt aat cat tat ttg ttc gat aaa actagtcgat        1344
Leu Glu Asn Leu Val Asn His Tyr Leu Phe Asp Lys
    430                 435                 440
 
gcct                                                              1348

<210> 176
<211> 440
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in S. cerevisiae

<400> 176
Met Gln Ala Tyr Phe Asp Gln Leu Asp Arg Val Arg Tyr Glu Gly Ser
 1               5                  10                  15      
Lys Ser Ser Asn Pro Leu Ala Phe Arg His Tyr Asn Pro Asp Glu Leu
            20                  25                  30          
Val Leu Gly Lys Arg Met Glu Glu His Leu Arg Phe Ala Ala Cys Tyr
        35                  40                  45              
Trp His Thr Phe Cys Trp Asn Gly Ala Asp Met Phe Gly Val Gly Ala
    50                  55                  60                  
Phe Asn Arg Pro Trp Gln Gln Pro Gly Glu Ala Leu Ala Leu Ala Lys
65                  70                  75                  80  
Arg Lys Ala Asp Val Ala Phe Glu Phe Phe His Lys Leu His Val Pro
                85                  90                  95      
Phe Tyr Cys Phe His Asp Val Asp Val Ser Pro Glu Gly Ala Ser Leu
            100                 105                 110         
Lys Glu Tyr Ile Asn Asn Phe Ala Gln Met Val Asp Val Leu Ala Gly
        115                 120                 125             
Lys Gln Glu Glu Ser Gly Val Lys Leu Leu Trp Gly Thr Ala Asn Cys
    130                 135                 140                 
Phe Thr Asn Pro Arg Tyr Gly Ala Gly Ala Ala Thr Asn Pro Asp Pro
145                 150                 155                 160 
Glu Val Phe Ser Trp Ala Ala Thr Gln Val Val Thr Ala Met Glu Ala
                165                 170                 175     
Thr His Lys Leu Gly Gly Glu Asn Tyr Val Leu Trp Gly Gly Arg Glu
            180                 185                 190         
Gly Tyr Glu Thr Leu Leu Asn Thr Asp Leu Arg Gln Glu Arg Glu Gln
        195                 200                 205             
Leu Gly Arg Phe Met Gln Met Val Val Glu His Lys His Lys Ile Gly
    210                 215                 220                 
Phe Gln Gly Thr Leu Leu Ile Glu Pro Lys Pro Gln Glu Pro Thr Lys
225                 230                 235                 240 
His Gln Tyr Asp Tyr Asp Ala Ala Thr Val Tyr Gly Phe Leu Lys Gln
                245                 250                 255     
Phe Gly Leu Glu Lys Glu Ile Lys Leu Asn Ile Glu Ala Asn His Ala
            260                 265                 270         
Thr Leu Ala Gly His Ser Phe His His Glu Ile Ala Thr Ala Ile Ala
        275                 280                 285             
Leu Gly Leu Phe Gly Ser Val Asp Ala Asn Arg Gly Asp Ala Gln Leu
    290                 295                 300                 
Gly Trp Asp Thr Asp Gln Phe Pro Asn Ser Val Glu Glu Asn Ala Leu
305                 310                 315                 320 
Val Met Tyr Glu Ile Leu Lys Ala Gly Gly Phe Thr Thr Gly Gly Leu
                325                 330                 335     
Asn Phe Asp Ala Lys Val Arg Arg Gln Ser Thr Asp Lys Tyr Asp Leu
            340                 345                 350         
Phe Tyr Gly His Ile Gly Ala Met Asp Thr Met Ala Leu Ala Leu Lys
        355                 360                 365             
Ile Ala Ala Arg Met Ile Glu Asp Gly Glu Leu Asp Lys Arg Ile Ala
    370                 375                 380                 
Gln Arg Tyr Ser Gly Trp Asn Ser Glu Leu Gly Gln Gln Ile Leu Lys
385                 390                 395                 400 
Gly Gln Met Ser Leu Ala Asp Leu Ala Lys Tyr Ala Gln Glu His His
                405                 410                 415     
Leu Ser Pro Val His Gln Ser Gly Arg Gln Glu Gln Leu Glu Asn Leu
            420                 425                 430         
Val Asn His Tyr Leu Phe Asp Lys
        435                 440 


<210> 177
<211> 1320
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in E. coli

<220> 
<221> CDS            
<222> (1)...(1320)

<400> 177
atg caa gca tat ttt gat caa ttg gat aga gtt aga tat gaa ggt tct   48
Met Gln Ala Tyr Phe Asp Gln Leu Asp Arg Val Arg Tyr Glu Gly Ser
 1               5                   10                  15
 
aaa tct tct aat cca ttg gct ttt aga cat tat aat cca gat gaa ttg   96
Lys Ser Ser Asn Pro Leu Ala Phe Arg His Tyr Asn Pro Asp Glu Leu
             20                  25                  30
 
gtt ttg ggt aag aga atg gag gaa cat ttg aga ttt gct gct tgt tat   144
Val Leu Gly Lys Arg Met Glu Glu His Leu Arg Phe Ala Ala Cys Tyr
         35                  40                  45
 
tgg cat act ttt tgt tgg aat ggt gct gat atg ttt ggc gta gga gct   192
Trp His Thr Phe Cys Trp Asn Gly Ala Asp Met Phe Gly Val Gly Ala
     50                  55                  60
 
ttt aat aga cca tgg cag caa cca ggt gag gct ttg gct cta gca aaa   240
Phe Asn Arg Pro Trp Gln Gln Pro Gly Glu Ala Leu Ala Leu Ala Lys
 65                  70                  75                  80
 
aga aag gct gat gtt gct ttt gag ttc ttt cat aaa ttg cat gtt cca   288
Arg Lys Ala Asp Val Ala Phe Glu Phe Phe His Lys Leu His Val Pro
                 85                  90                  95
 
ttt tat tgt ttt cat gat gtt gat gta tca cca gaa gga gca tct tta   336
Phe Tyr Cys Phe His Asp Val Asp Val Ser Pro Glu Gly Ala Ser Leu
            100                 105                 110
 
aaa gaa tat att aat aat ttt gct caa atg gtt gat gtt tta gct gga   384
Lys Glu Tyr Ile Asn Asn Phe Ala Gln Met Val Asp Val Leu Ala Gly
        115                 120                 125
 
aaa cag gaa gaa tct ggt gtt aaa ttg tta tgg ggt act gct aat tgt   432
Lys Gln Glu Glu Ser Gly Val Lys Leu Leu Trp Gly Thr Ala Asn Cys
    130                 135                 140
 
ttt act aat cct aga tat ggt gca gga gcc gct aca aat cca gat cca   480
Phe Thr Asn Pro Arg Tyr Gly Ala Gly Ala Ala Thr Asn Pro Asp Pro
145                 150                 155                 160
 
gaa gtt ttt agt tgg gct gct aca caa gta gtt act gct atg gaa gct   528
Glu Val Phe Ser Trp Ala Ala Thr Gln Val Val Thr Ala Met Glu Ala
                165                 170                 175
 
acc cat aaa tta ggt ggt gaa aat tat gtt ttg tgg ggt ggt aga gaa   576
Thr His Lys Leu Gly Gly Glu Asn Tyr Val Leu Trp Gly Gly Arg Glu
            180                 185                 190
 
ggt tat gaa aca ttg tta aat act gat ttg aga caa gaa aga gaa caa   624
Gly Tyr Glu Thr Leu Leu Asn Thr Asp Leu Arg Gln Glu Arg Glu Gln
        195                 200                 205
 
ttg ggt aga ttt atg caa atg gtt gtt gaa cat aaa cat aaa att ggt   672
Leu Gly Arg Phe Met Gln Met Val Val Glu His Lys His Lys Ile Gly
    210                 215                 220
 
ttt caa ggt aca ttg ttg att gaa cca aaa cca caa gaa cca act aaa   720
Phe Gln Gly Thr Leu Leu Ile Glu Pro Lys Pro Gln Glu Pro Thr Lys
225                 230                 235                 240
 
cat caa tat gat tat gat gct gct aca gtt tat ggt ttt cta aaa caa   768
His Gln Tyr Asp Tyr Asp Ala Ala Thr Val Tyr Gly Phe Leu Lys Gln
                245                 250                 255
 
ttt gga tta gaa aaa gaa att aaa tta aac att gaa gct aat cat gct   816
Phe Gly Leu Glu Lys Glu Ile Lys Leu Asn Ile Glu Ala Asn His Ala
            260                 265                 270
 
aca ttg gct ggt cat tct ttt cat cat gaa att gca act gct ata gct   864
Thr Leu Ala Gly His Ser Phe His His Glu Ile Ala Thr Ala Ile Ala
        275                 280                 285
 
tta ggt ttg ttc ggt tct gtt gat gct aat aga ggt gat gct caa ttg   912
Leu Gly Leu Phe Gly Ser Val Asp Ala Asn Arg Gly Asp Ala Gln Leu
    290                 295                 300
 
ggt tgg gat act gat caa ttt cca aat tct gtt gaa gaa aat gct ttg   960
Gly Trp Asp Thr Asp Gln Phe Pro Asn Ser Val Glu Glu Asn Ala Leu
305                 310                 315                 320
 
gtt atg tat gaa att tta aaa gct ggt ggt ttt act act ggt ggt tta   1008
Val Met Tyr Glu Ile Leu Lys Ala Gly Gly Phe Thr Thr Gly Gly Leu
                325                 330                 335
 
aat ttt gat gct aaa gta agg aga caa tct aca gat aaa tat gat ttg   1056
Asn Phe Asp Ala Lys Val Arg Arg Gln Ser Thr Asp Lys Tyr Asp Leu
            340                 345                 350
 
ttt tat ggt cat att ggt gct atg gat act atg gca ttg gca tta aaa   1104
Phe Tyr Gly His Ile Gly Ala Met Asp Thr Met Ala Leu Ala Leu Lys
        355                 360                 365
 
att gct gct aga atg att gaa gat ggt gaa ttg gat aaa aga att gct   1152
Ile Ala Ala Arg Met Ile Glu Asp Gly Glu Leu Asp Lys Arg Ile Ala
    370                 375                 380
 
caa aga tat tct ggt tgg aat agt gag ttg ggt caa caa att tta aag   1200
Gln Arg Tyr Ser Gly Trp Asn Ser Glu Leu Gly Gln Gln Ile Leu Lys
385                 390                 395                 400
 
ggt caa atg tct ttg gct gat ttg gct aaa tat gct caa gaa cat cat   1248
Gly Gln Met Ser Leu Ala Asp Leu Ala Lys Tyr Ala Gln Glu His His
                405                 410                 415
 
ttg tca cca gtt cat caa tca ggt aga caa gaa caa ttg gaa aat ttg   1296
Leu Ser Pro Val His Gln Ser Gly Arg Gln Glu Gln Leu Glu Asn Leu
            420                 425                 430
 
gtt aat cat tat ttg ttc gat aaa                                   1320
Val Asn His Tyr Leu Phe Asp Lys
        435                 440
 

<210> 178
<211> 440
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in E. coli

<400> 178
Met Gln Ala Tyr Phe Asp Gln Leu Asp Arg Val Arg Tyr Glu Gly Ser
 1               5                  10                  15      
Lys Ser Ser Asn Pro Leu Ala Phe Arg His Tyr Asn Pro Asp Glu Leu
            20                  25                  30          
Val Leu Gly Lys Arg Met Glu Glu His Leu Arg Phe Ala Ala Cys Tyr
        35                  40                  45              
Trp His Thr Phe Cys Trp Asn Gly Ala Asp Met Phe Gly Val Gly Ala
    50                  55                  60                  
Phe Asn Arg Pro Trp Gln Gln Pro Gly Glu Ala Leu Ala Leu Ala Lys
65                  70                  75                  80  
Arg Lys Ala Asp Val Ala Phe Glu Phe Phe His Lys Leu His Val Pro
                85                  90                  95      
Phe Tyr Cys Phe His Asp Val Asp Val Ser Pro Glu Gly Ala Ser Leu
            100                 105                 110         
Lys Glu Tyr Ile Asn Asn Phe Ala Gln Met Val Asp Val Leu Ala Gly
        115                 120                 125             
Lys Gln Glu Glu Ser Gly Val Lys Leu Leu Trp Gly Thr Ala Asn Cys
    130                 135                 140                 
Phe Thr Asn Pro Arg Tyr Gly Ala Gly Ala Ala Thr Asn Pro Asp Pro
145                 150                 155                 160 
Glu Val Phe Ser Trp Ala Ala Thr Gln Val Val Thr Ala Met Glu Ala
                165                 170                 175     
Thr His Lys Leu Gly Gly Glu Asn Tyr Val Leu Trp Gly Gly Arg Glu
            180                 185                 190         
Gly Tyr Glu Thr Leu Leu Asn Thr Asp Leu Arg Gln Glu Arg Glu Gln
        195                 200                 205             
Leu Gly Arg Phe Met Gln Met Val Val Glu His Lys His Lys Ile Gly
    210                 215                 220                 
Phe Gln Gly Thr Leu Leu Ile Glu Pro Lys Pro Gln Glu Pro Thr Lys
225                 230                 235                 240 
His Gln Tyr Asp Tyr Asp Ala Ala Thr Val Tyr Gly Phe Leu Lys Gln
                245                 250                 255     
Phe Gly Leu Glu Lys Glu Ile Lys Leu Asn Ile Glu Ala Asn His Ala
            260                 265                 270         
Thr Leu Ala Gly His Ser Phe His His Glu Ile Ala Thr Ala Ile Ala
        275                 280                 285             
Leu Gly Leu Phe Gly Ser Val Asp Ala Asn Arg Gly Asp Ala Gln Leu
    290                 295                 300                 
Gly Trp Asp Thr Asp Gln Phe Pro Asn Ser Val Glu Glu Asn Ala Leu
305                 310                 315                 320 
Val Met Tyr Glu Ile Leu Lys Ala Gly Gly Phe Thr Thr Gly Gly Leu
                325                 330                 335     
Asn Phe Asp Ala Lys Val Arg Arg Gln Ser Thr Asp Lys Tyr Asp Leu
            340                 345                 350         
Phe Tyr Gly His Ile Gly Ala Met Asp Thr Met Ala Leu Ala Leu Lys
        355                 360                 365             
Ile Ala Ala Arg Met Ile Glu Asp Gly Glu Leu Asp Lys Arg Ile Ala
    370                 375                 380                 
Gln Arg Tyr Ser Gly Trp Asn Ser Glu Leu Gly Gln Gln Ile Leu Lys
385                 390                 395                 400 
Gly Gln Met Ser Leu Ala Asp Leu Ala Lys Tyr Ala Gln Glu His His
                405                 410                 415     
Leu Ser Pro Val His Gln Ser Gly Arg Gln Glu Gln Leu Glu Asn Leu
            420                 425                 430         
Val Asn His Tyr Leu Phe Asp Lys
        435                 440 


<210> 179
<211> 1342
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in E. coli

<220> 
<221> CDS            
<222> (12)...(1331)

<400> 179
tactcaagct t atg caa gca tat ttt gat caa ttg gat aga gtt aga tat  50
             Met Gln Ala Tyr Phe Asp Gln Leu Asp Arg Val Arg Tyr
              1               5                   10
 
gaa ggt tct aaa tct tct aat cca ttg gct ttt aga cat tat aat cca   98
Glu Gly Ser Lys Ser Ser Asn Pro Leu Ala Phe Arg His Tyr Asn Pro
     15                  20                  25
 
gat gaa ttg gtt ttg ggt aag aga atg gag gaa cat ttg aga ttt gct   146
Asp Glu Leu Val Leu Gly Lys Arg Met Glu Glu His Leu Arg Phe Ala
 30                  35                  40                  45
 
gct tgt tat tgg cat act ttt tgt tgg aat ggt gct gat atg ttt ggc   194
Ala Cys Tyr Trp His Thr Phe Cys Trp Asn Gly Ala Asp Met Phe Gly
                 50                  55                  60
 
gta gga gct ttt aat aga cca tgg cag caa cca ggt gag gct ttg gct   242
Val Gly Ala Phe Asn Arg Pro Trp Gln Gln Pro Gly Glu Ala Leu Ala
             65                  70                  75
 
cta gca aaa aga aag gct gat gtt gct ttt gag ttc ttt cat aaa ttg   290
Leu Ala Lys Arg Lys Ala Asp Val Ala Phe Glu Phe Phe His Lys Leu
         80                  85                  90
 
cat gtt cca ttt tat tgt ttt cat gat gtt gat gta tca cca gaa gga   338
His Val Pro Phe Tyr Cys Phe His Asp Val Asp Val Ser Pro Glu Gly
     95                 100                 105
 
gca tct tta aaa gaa tat att aat aat ttt gct caa atg gtt gat gtt   386
Ala Ser Leu Lys Glu Tyr Ile Asn Asn Phe Ala Gln Met Val Asp Val
110                 115                 120                 125
 
tta gct gga aaa cag gaa gaa tct ggt gtt aaa ttg tta tgg ggt act   434
Leu Ala Gly Lys Gln Glu Glu Ser Gly Val Lys Leu Leu Trp Gly Thr
                130                 135                 140
 
gct aat tgt ttt act aat cct aga tat ggt gca gga gcc gct aca aat   482
Ala Asn Cys Phe Thr Asn Pro Arg Tyr Gly Ala Gly Ala Ala Thr Asn
            145                 150                 155
 
cca gat cca gaa gtt ttt agt tgg gct gct aca caa gta gtt act gct   530
Pro Asp Pro Glu Val Phe Ser Trp Ala Ala Thr Gln Val Val Thr Ala
        160                 165                 170
 
atg gaa gct acc cat aaa tta ggt ggt gaa aat tat gtt ttg tgg ggt   578
Met Glu Ala Thr His Lys Leu Gly Gly Glu Asn Tyr Val Leu Trp Gly
    175                 180                 185
 
ggt aga gaa ggt tat gaa aca ttg tta aat act gat ttg aga caa gaa   626
Gly Arg Glu Gly Tyr Glu Thr Leu Leu Asn Thr Asp Leu Arg Gln Glu
190                 195                 200                 205
 
aga gaa caa ttg ggt aga ttt atg caa atg gtt gtt gaa cat aaa cat   674
Arg Glu Gln Leu Gly Arg Phe Met Gln Met Val Val Glu His Lys His
                210                 215                 220
 
aaa att ggt ttt caa ggt aca ttg ttg att gaa cca aaa cca caa gaa   722
Lys Ile Gly Phe Gln Gly Thr Leu Leu Ile Glu Pro Lys Pro Gln Glu
            225                 230                 235
 
cca act aaa cat caa tat gat tat gat gct gct aca gtt tat ggt ttt   770
Pro Thr Lys His Gln Tyr Asp Tyr Asp Ala Ala Thr Val Tyr Gly Phe
        240                 245                 250
 
cta aaa caa ttt gga tta gaa aaa gaa att aaa tta aac att gaa gct   818
Leu Lys Gln Phe Gly Leu Glu Lys Glu Ile Lys Leu Asn Ile Glu Ala
    255                 260                 265
 
aat cat gct aca ttg gct ggt cat tct ttt cat cat gaa att gca act   866
Asn His Ala Thr Leu Ala Gly His Ser Phe His His Glu Ile Ala Thr
270                 275                 280                 285
 
gct ata gct tta ggt ttg ttc ggt tct gtt gat gct aat aga ggt gat   914
Ala Ile Ala Leu Gly Leu Phe Gly Ser Val Asp Ala Asn Arg Gly Asp
                290                 295                 300
 
gct caa ttg ggt tgg gat act gat caa ttt cca aat tct gtt gaa gaa   962
Ala Gln Leu Gly Trp Asp Thr Asp Gln Phe Pro Asn Ser Val Glu Glu
            305                 310                 315
 
aat gct ttg gtt atg tat gaa att tta aaa gct ggt ggt ttt act act   1010
Asn Ala Leu Val Met Tyr Glu Ile Leu Lys Ala Gly Gly Phe Thr Thr
        320                 325                 330
 
ggt ggt tta aat ttt gat gct aaa gta agg aga caa tct aca gat aaa   1058
Gly Gly Leu Asn Phe Asp Ala Lys Val Arg Arg Gln Ser Thr Asp Lys
    335                 340                 345
 
tat gat ttg ttt tat ggt cat att ggt gct atg gat act atg gca ttg   1106
Tyr Asp Leu Phe Tyr Gly His Ile Gly Ala Met Asp Thr Met Ala Leu
350                 355                 360                 365
 
gca tta aaa att gct gct aga atg att gaa gat ggt gaa ttg gat aaa   1154
Ala Leu Lys Ile Ala Ala Arg Met Ile Glu Asp Gly Glu Leu Asp Lys
                370                 375                 380
 
aga att gct caa aga tat tct ggt tgg aat agt gag ttg ggt caa caa   1202
Arg Ile Ala Gln Arg Tyr Ser Gly Trp Asn Ser Glu Leu Gly Gln Gln
            385                 390                 395
 
att tta aag ggt caa atg tct ttg gct gat ttg gct aaa tat gct caa   1250
Ile Leu Lys Gly Gln Met Ser Leu Ala Asp Leu Ala Lys Tyr Ala Gln
        400                 405                 410
 
gaa cat cat ttg tca cca gtt cat caa tca ggt aga caa gaa caa ttg   1298
Glu His His Leu Ser Pro Val His Gln Ser Gly Arg Gln Glu Gln Leu
    415                 420                 425
 
gaa aat ttg gtt aat cat tat ttg ttc gat aaa gaattccgat g          1342
Glu Asn Leu Val Asn His Tyr Leu Phe Asp Lys
430                 435                 440
 

<210> 180
<211> 440
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in E. coli

<400> 180
Met Gln Ala Tyr Phe Asp Gln Leu Asp Arg Val Arg Tyr Glu Gly Ser
 1               5                  10                  15      
Lys Ser Ser Asn Pro Leu Ala Phe Arg His Tyr Asn Pro Asp Glu Leu
            20                  25                  30          
Val Leu Gly Lys Arg Met Glu Glu His Leu Arg Phe Ala Ala Cys Tyr
        35                  40                  45              
Trp His Thr Phe Cys Trp Asn Gly Ala Asp Met Phe Gly Val Gly Ala
    50                  55                  60                  
Phe Asn Arg Pro Trp Gln Gln Pro Gly Glu Ala Leu Ala Leu Ala Lys
65                  70                  75                  80  
Arg Lys Ala Asp Val Ala Phe Glu Phe Phe His Lys Leu His Val Pro
                85                  90                  95      
Phe Tyr Cys Phe His Asp Val Asp Val Ser Pro Glu Gly Ala Ser Leu
            100                 105                 110         
Lys Glu Tyr Ile Asn Asn Phe Ala Gln Met Val Asp Val Leu Ala Gly
        115                 120                 125             
Lys Gln Glu Glu Ser Gly Val Lys Leu Leu Trp Gly Thr Ala Asn Cys
    130                 135                 140                 
Phe Thr Asn Pro Arg Tyr Gly Ala Gly Ala Ala Thr Asn Pro Asp Pro
145                 150                 155                 160 
Glu Val Phe Ser Trp Ala Ala Thr Gln Val Val Thr Ala Met Glu Ala
                165                 170                 175     
Thr His Lys Leu Gly Gly Glu Asn Tyr Val Leu Trp Gly Gly Arg Glu
            180                 185                 190         
Gly Tyr Glu Thr Leu Leu Asn Thr Asp Leu Arg Gln Glu Arg Glu Gln
        195                 200                 205             
Leu Gly Arg Phe Met Gln Met Val Val Glu His Lys His Lys Ile Gly
    210                 215                 220                 
Phe Gln Gly Thr Leu Leu Ile Glu Pro Lys Pro Gln Glu Pro Thr Lys
225                 230                 235                 240 
His Gln Tyr Asp Tyr Asp Ala Ala Thr Val Tyr Gly Phe Leu Lys Gln
                245                 250                 255     
Phe Gly Leu Glu Lys Glu Ile Lys Leu Asn Ile Glu Ala Asn His Ala
            260                 265                 270         
Thr Leu Ala Gly His Ser Phe His His Glu Ile Ala Thr Ala Ile Ala
        275                 280                 285             
Leu Gly Leu Phe Gly Ser Val Asp Ala Asn Arg Gly Asp Ala Gln Leu
    290                 295                 300                 
Gly Trp Asp Thr Asp Gln Phe Pro Asn Ser Val Glu Glu Asn Ala Leu
305                 310                 315                 320 
Val Met Tyr Glu Ile Leu Lys Ala Gly Gly Phe Thr Thr Gly Gly Leu
                325                 330                 335     
Asn Phe Asp Ala Lys Val Arg Arg Gln Ser Thr Asp Lys Tyr Asp Leu
            340                 345                 350         
Phe Tyr Gly His Ile Gly Ala Met Asp Thr Met Ala Leu Ala Leu Lys
        355                 360                 365             
Ile Ala Ala Arg Met Ile Glu Asp Gly Glu Leu Asp Lys Arg Ile Ala
    370                 375                 380                 
Gln Arg Tyr Ser Gly Trp Asn Ser Glu Leu Gly Gln Gln Ile Leu Lys
385                 390                 395                 400 
Gly Gln Met Ser Leu Ala Asp Leu Ala Lys Tyr Ala Gln Glu His His
                405                 410                 415     
Leu Ser Pro Val His Gln Ser Gly Arg Gln Glu Gln Leu Glu Asn Leu
            420                 425                 430         
Val Asn His Tyr Leu Phe Asp Lys
        435                 440 


<210> 181
<211> 1348
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in E. coli

<220> 
<221> CDS            
<222> (15)...(1334)

<400> 181
gaatactcca tatg atg caa gca tat ttt gat caa ttg gat aga gtt aga   50
                Met Gln Ala Tyr Phe Asp Gln Leu Asp Arg Val Arg
                 1               5                   10
 
tat gaa ggt tct aaa tct tct aat cca ttg gct ttt aga cat tat aat   98
Tyr Glu Gly Ser Lys Ser Ser Asn Pro Leu Ala Phe Arg His Tyr Asn
         15                  20                  25
 
cca gat gaa ttg gtt ttg ggt aag aga atg gag gaa cat ttg aga ttt   146
Pro Asp Glu Leu Val Leu Gly Lys Arg Met Glu Glu His Leu Arg Phe
     30                  35                  40
 
gct gct tgt tat tgg cat act ttt tgt tgg aat ggt gct gat atg ttt   194
Ala Ala Cys Tyr Trp His Thr Phe Cys Trp Asn Gly Ala Asp Met Phe
 45                  50                  55                  60
 
ggc gta gga gct ttt aat aga cca tgg cag caa cca ggt gag gct ttg   242
Gly Val Gly Ala Phe Asn Arg Pro Trp Gln Gln Pro Gly Glu Ala Leu
                 65                  70                  75
 
gct cta gca aaa aga aag gct gat gtt gct ttt gag ttc ttt cat aaa   290
Ala Leu Ala Lys Arg Lys Ala Asp Val Ala Phe Glu Phe Phe His Lys
             80                  85                  90
 
ttg cat gtt cca ttt tat tgt ttt cat gat gtt gat gta tca cca gaa   338
Leu His Val Pro Phe Tyr Cys Phe His Asp Val Asp Val Ser Pro Glu
         95                 100                 105
 
gga gca tct tta aaa gaa tat att aat aat ttt gct caa atg gtt gat   386
Gly Ala Ser Leu Lys Glu Tyr Ile Asn Asn Phe Ala Gln Met Val Asp
    110                 115                 120
 
gtt tta gct gga aaa cag gaa gaa tct ggt gtt aaa ttg tta tgg ggt   434
Val Leu Ala Gly Lys Gln Glu Glu Ser Gly Val Lys Leu Leu Trp Gly
125                 130                 135                 140
 
act gct aat tgt ttt act aat cct aga tat ggt gca gga gcc gct aca   482
Thr Ala Asn Cys Phe Thr Asn Pro Arg Tyr Gly Ala Gly Ala Ala Thr
                145                 150                 155
 
aat cca gat cca gaa gtt ttt agt tgg gct gct aca caa gta gtt act   530
Asn Pro Asp Pro Glu Val Phe Ser Trp Ala Ala Thr Gln Val Val Thr
            160                 165                 170
 
gct atg gaa gct acc cat aaa tta ggt ggt gaa aat tat gtt ttg tgg   578
Ala Met Glu Ala Thr His Lys Leu Gly Gly Glu Asn Tyr Val Leu Trp
        175                 180                 185
 
ggt ggt aga gaa ggt tat gaa aca ttg tta aat act gat ttg aga caa   626
Gly Gly Arg Glu Gly Tyr Glu Thr Leu Leu Asn Thr Asp Leu Arg Gln
    190                 195                 200
 
gaa aga gaa caa ttg ggt aga ttt atg caa atg gtt gtt gaa cat aaa   674
Glu Arg Glu Gln Leu Gly Arg Phe Met Gln Met Val Val Glu His Lys
205                 210                 215                 220
 
cat aaa att ggt ttt caa ggt aca ttg ttg att gaa cca aaa cca caa   722
His Lys Ile Gly Phe Gln Gly Thr Leu Leu Ile Glu Pro Lys Pro Gln
                225                 230                 235
 
gaa cca act aaa cat caa tat gat tat gat gct gct aca gtt tat ggt   770
Glu Pro Thr Lys His Gln Tyr Asp Tyr Asp Ala Ala Thr Val Tyr Gly
            240                 245                 250
 
ttt cta aaa caa ttt gga tta gaa aaa gaa att aaa tta aac att gaa   818
Phe Leu Lys Gln Phe Gly Leu Glu Lys Glu Ile Lys Leu Asn Ile Glu
        255                 260                 265
 
gct aat cat gct aca ttg gct ggt cat tct ttt cat cat gaa att gca   866
Ala Asn His Ala Thr Leu Ala Gly His Ser Phe His His Glu Ile Ala
    270                 275                 280
 
act gct ata gct tta ggt ttg ttc ggt tct gtt gat gct aat aga ggt   914
Thr Ala Ile Ala Leu Gly Leu Phe Gly Ser Val Asp Ala Asn Arg Gly
285                 290                 295                 300
 
gat gct caa ttg ggt tgg gat act gat caa ttt cca aat tct gtt gaa   962
Asp Ala Gln Leu Gly Trp Asp Thr Asp Gln Phe Pro Asn Ser Val Glu
                305                 310                 315
 
gaa aat gct ttg gtt atg tat gaa att tta aaa gct ggt ggt ttt act   1010
Glu Asn Ala Leu Val Met Tyr Glu Ile Leu Lys Ala Gly Gly Phe Thr
            320                 325                 330
 
act ggt ggt tta aat ttt gat gct aaa gta agg aga caa tct aca gat   1058
Thr Gly Gly Leu Asn Phe Asp Ala Lys Val Arg Arg Gln Ser Thr Asp
        335                 340                 345
 
aaa tat gat ttg ttt tat ggt cat att ggt gct atg gat act atg gca   1106
Lys Tyr Asp Leu Phe Tyr Gly His Ile Gly Ala Met Asp Thr Met Ala
    350                 355                 360
 
ttg gca tta aaa att gct gct aga atg att gaa gat ggt gaa ttg gat   1154
Leu Ala Leu Lys Ile Ala Ala Arg Met Ile Glu Asp Gly Glu Leu Asp
365                 370                 375                 380
 
aaa aga att gct caa aga tat tct ggt tgg aat agt gag ttg ggt caa   1202
Lys Arg Ile Ala Gln Arg Tyr Ser Gly Trp Asn Ser Glu Leu Gly Gln
                385                 390                 395
 
caa att tta aag ggt caa atg tct ttg gct gat ttg gct aaa tat gct   1250
Gln Ile Leu Lys Gly Gln Met Ser Leu Ala Asp Leu Ala Lys Tyr Ala
            400                 405                 410
 
caa gaa cat cat ttg tca cca gtt cat caa tca ggt aga caa gaa caa   1298
Gln Glu His His Leu Ser Pro Val His Gln Ser Gly Arg Gln Glu Gln
        415                 420                 425
 
ttg gaa aat ttg gtt aat cat tat ttg ttc gat aaa actagtcgat        1344
Leu Glu Asn Leu Val Asn His Tyr Leu Phe Asp Lys
    430                 435                 440
 
gcct                                                              1348

<210> 182
<211> 440
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in E. coli

<400> 182
Met Gln Ala Tyr Phe Asp Gln Leu Asp Arg Val Arg Tyr Glu Gly Ser
 1               5                  10                  15      
Lys Ser Ser Asn Pro Leu Ala Phe Arg His Tyr Asn Pro Asp Glu Leu
            20                  25                  30          
Val Leu Gly Lys Arg Met Glu Glu His Leu Arg Phe Ala Ala Cys Tyr
        35                  40                  45              
Trp His Thr Phe Cys Trp Asn Gly Ala Asp Met Phe Gly Val Gly Ala
    50                  55                  60                  
Phe Asn Arg Pro Trp Gln Gln Pro Gly Glu Ala Leu Ala Leu Ala Lys
65                  70                  75                  80  
Arg Lys Ala Asp Val Ala Phe Glu Phe Phe His Lys Leu His Val Pro
                85                  90                  95      
Phe Tyr Cys Phe His Asp Val Asp Val Ser Pro Glu Gly Ala Ser Leu
            100                 105                 110         
Lys Glu Tyr Ile Asn Asn Phe Ala Gln Met Val Asp Val Leu Ala Gly
        115                 120                 125             
Lys Gln Glu Glu Ser Gly Val Lys Leu Leu Trp Gly Thr Ala Asn Cys
    130                 135                 140                 
Phe Thr Asn Pro Arg Tyr Gly Ala Gly Ala Ala Thr Asn Pro Asp Pro
145                 150                 155                 160 
Glu Val Phe Ser Trp Ala Ala Thr Gln Val Val Thr Ala Met Glu Ala
                165                 170                 175     
Thr His Lys Leu Gly Gly Glu Asn Tyr Val Leu Trp Gly Gly Arg Glu
            180                 185                 190         
Gly Tyr Glu Thr Leu Leu Asn Thr Asp Leu Arg Gln Glu Arg Glu Gln
        195                 200                 205             
Leu Gly Arg Phe Met Gln Met Val Val Glu His Lys His Lys Ile Gly
    210                 215                 220                 
Phe Gln Gly Thr Leu Leu Ile Glu Pro Lys Pro Gln Glu Pro Thr Lys
225                 230                 235                 240 
His Gln Tyr Asp Tyr Asp Ala Ala Thr Val Tyr Gly Phe Leu Lys Gln
                245                 250                 255     
Phe Gly Leu Glu Lys Glu Ile Lys Leu Asn Ile Glu Ala Asn His Ala
            260                 265                 270         
Thr Leu Ala Gly His Ser Phe His His Glu Ile Ala Thr Ala Ile Ala
        275                 280                 285             
Leu Gly Leu Phe Gly Ser Val Asp Ala Asn Arg Gly Asp Ala Gln Leu
    290                 295                 300                 
Gly Trp Asp Thr Asp Gln Phe Pro Asn Ser Val Glu Glu Asn Ala Leu
305                 310                 315                 320 
Val Met Tyr Glu Ile Leu Lys Ala Gly Gly Phe Thr Thr Gly Gly Leu
                325                 330                 335     
Asn Phe Asp Ala Lys Val Arg Arg Gln Ser Thr Asp Lys Tyr Asp Leu
            340                 345                 350         
Phe Tyr Gly His Ile Gly Ala Met Asp Thr Met Ala Leu Ala Leu Lys
        355                 360                 365             
Ile Ala Ala Arg Met Ile Glu Asp Gly Glu Leu Asp Lys Arg Ile Ala
    370                 375                 380                 
Gln Arg Tyr Ser Gly Trp Asn Ser Glu Leu Gly Gln Gln Ile Leu Lys
385                 390                 395                 400 
Gly Gln Met Ser Leu Ala Asp Leu Ala Lys Tyr Ala Gln Glu His His
                405                 410                 415     
Leu Ser Pro Val His Gln Ser Gly Arg Gln Glu Gln Leu Glu Asn Leu
            420                 425                 430         
Val Asn His Tyr Leu Phe Asp Lys
        435                 440 


<210> 183
<211> 1320
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in P. pastoris

<220> 
<221> CDS            
<222> (1)...(1320)

<400> 183
atg cag gct tat ttt gat caa ttg gat aga gtt aga tat gaa gga tct   48
Met Gln Ala Tyr Phe Asp Gln Leu Asp Arg Val Arg Tyr Glu Gly Ser
 1               5                   10                  15
 
aaa tct tct aat cca ttg gct ttt aga cat tat aat cca gat gaa ttg   96
Lys Ser Ser Asn Pro Leu Ala Phe Arg His Tyr Asn Pro Asp Glu Leu
             20                  25                  30
 
gtt ttg gga aaa aga atg gaa gaa cat ttg aga ttt gca gct tgt tat   144
Val Leu Gly Lys Arg Met Glu Glu His Leu Arg Phe Ala Ala Cys Tyr
         35                  40                  45
 
tgg cat act ttt tgt tgg aat gga gct gat atg ttt ggt gtg gga gct   192
Trp His Thr Phe Cys Trp Asn Gly Ala Asp Met Phe Gly Val Gly Ala
     50                  55                  60
 
ttt aat aga cca tgg caa caa cca gga gag gct ctt gct tta gct aag   240
Phe Asn Arg Pro Trp Gln Gln Pro Gly Glu Ala Leu Ala Leu Ala Lys
 65                  70                  75                  80
 
aga aag gcc gat gtt gca ttc gag ttc ttt cat aaa ttg cat gtt cca   288
Arg Lys Ala Asp Val Ala Phe Glu Phe Phe His Lys Leu His Val Pro
                 85                  90                  95
 
ttt tat tgt ttt cat gat gtg gat gtt tct cca gaa ggt gca tct tta   336
Phe Tyr Cys Phe His Asp Val Asp Val Ser Pro Glu Gly Ala Ser Leu
            100                 105                 110
 
aaa gaa tat att aat aat ttc gct caa atg gtt gat gtt ttg gct gga   384
Lys Glu Tyr Ile Asn Asn Phe Ala Gln Met Val Asp Val Leu Ala Gly
        115                 120                 125
 
aaa caa gaa gaa tct gga gtt aaa tta tta tgg ggc act gct aat tgt   432
Lys Gln Glu Glu Ser Gly Val Lys Leu Leu Trp Gly Thr Ala Asn Cys
    130                 135                 140
 
ttt act aat cct aga tac ggt gct gga gct gca act aat cct gat cct   480
Phe Thr Asn Pro Arg Tyr Gly Ala Gly Ala Ala Thr Asn Pro Asp Pro
145                 150                 155                 160
 
gaa gtt ttc tct tgg gct gct act caa gtt gtt act gct atg gaa gct   528
Glu Val Phe Ser Trp Ala Ala Thr Gln Val Val Thr Ala Met Glu Ala
                165                 170                 175
 
aca cat aaa tta gga gga gaa aat tat gtt ttg tgg gga ggt aga gaa   576
Thr His Lys Leu Gly Gly Glu Asn Tyr Val Leu Trp Gly Gly Arg Glu
            180                 185                 190
 
gga tat gaa aca ttg tta aat act gat ttg aga caa gaa aga gaa caa   624
Gly Tyr Glu Thr Leu Leu Asn Thr Asp Leu Arg Gln Glu Arg Glu Gln
        195                 200                 205
 
ttg ggt aga ttt atg caa atg gtt gtt gaa cat aaa cat aaa att gga   672
Leu Gly Arg Phe Met Gln Met Val Val Glu His Lys His Lys Ile Gly
    210                 215                 220
 
ttt caa gga aca ttg ttg att gaa cca aag cca caa gaa cca act aaa   720
Phe Gln Gly Thr Leu Leu Ile Glu Pro Lys Pro Gln Glu Pro Thr Lys
225                 230                 235                 240
 
cat caa tat gat tat gat gct gct act gtt tat gga ttt tta aaa caa   768
His Gln Tyr Asp Tyr Asp Ala Ala Thr Val Tyr Gly Phe Leu Lys Gln
                245                 250                 255
 
ttt ggt tta gaa aaa gaa att aaa tta aac att gaa gct aat cat gct   816
Phe Gly Leu Glu Lys Glu Ile Lys Leu Asn Ile Glu Ala Asn His Ala
            260                 265                 270
 
aca ttg gct gga cat tct ttt cat cat gaa atc gct act gct att gct   864
Thr Leu Ala Gly His Ser Phe His His Glu Ile Ala Thr Ala Ile Ala
        275                 280                 285
 
tta gga ttg ttt ggt tct gtt gat gct aat aga gga gat gct caa ttg   912
Leu Gly Leu Phe Gly Ser Val Asp Ala Asn Arg Gly Asp Ala Gln Leu
    290                 295                 300
 
gga tgg gat act gat caa ttt cca aat tct gtt gaa gaa aat gca ttg   960
Gly Trp Asp Thr Asp Gln Phe Pro Asn Ser Val Glu Glu Asn Ala Leu
305                 310                 315                 320
 
gtt atg tat gaa att ttg aag gct gga gga ttt act act gga gga tta   1008
Val Met Tyr Glu Ile Leu Lys Ala Gly Gly Phe Thr Thr Gly Gly Leu
                325                 330                 335
 
aat ttt gat gct aaa gtt aga aga caa tct act gat aaa tat gat ttg   1056
Asn Phe Asp Ala Lys Val Arg Arg Gln Ser Thr Asp Lys Tyr Asp Leu
            340                 345                 350
 
ttt tat gga cat att gga gct atg gat act atg gct ttg gct tta aaa   1104
Phe Tyr Gly His Ile Gly Ala Met Asp Thr Met Ala Leu Ala Leu Lys
        355                 360                 365
 
att gct gct aga atg att gaa gat gga gaa ttg gat aaa aga att gct   1152
Ile Ala Ala Arg Met Ile Glu Asp Gly Glu Leu Asp Lys Arg Ile Ala
    370                 375                 380
 
caa aga tat tct gga tgg aat agt gag ttg gga cag caa att tta aaa   1200
Gln Arg Tyr Ser Gly Trp Asn Ser Glu Leu Gly Gln Gln Ile Leu Lys
385                 390                 395                 400
 
gga caa atg tct tta gca gat ttg gca aag tac gct caa gaa cat cat   1248
Gly Gln Met Ser Leu Ala Asp Leu Ala Lys Tyr Ala Gln Glu His His
                405                 410                 415
 
ttg tct cca gtt cat caa tca ggt aga caa gaa caa tta gaa aat ttg   1296
Leu Ser Pro Val His Gln Ser Gly Arg Gln Glu Gln Leu Glu Asn Leu
            420                 425                 430
 
gtt aat cat tat tta ttt gat aaa                                   1320
Val Asn His Tyr Leu Phe Asp Lys
        435                 440
 

<210> 184
<211> 440
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in P. pastoris

<400> 184
Met Gln Ala Tyr Phe Asp Gln Leu Asp Arg Val Arg Tyr Glu Gly Ser
 1               5                  10                  15      
Lys Ser Ser Asn Pro Leu Ala Phe Arg His Tyr Asn Pro Asp Glu Leu
            20                  25                  30          
Val Leu Gly Lys Arg Met Glu Glu His Leu Arg Phe Ala Ala Cys Tyr
        35                  40                  45              
Trp His Thr Phe Cys Trp Asn Gly Ala Asp Met Phe Gly Val Gly Ala
    50                  55                  60                  
Phe Asn Arg Pro Trp Gln Gln Pro Gly Glu Ala Leu Ala Leu Ala Lys
65                  70                  75                  80  
Arg Lys Ala Asp Val Ala Phe Glu Phe Phe His Lys Leu His Val Pro
                85                  90                  95      
Phe Tyr Cys Phe His Asp Val Asp Val Ser Pro Glu Gly Ala Ser Leu
            100                 105                 110         
Lys Glu Tyr Ile Asn Asn Phe Ala Gln Met Val Asp Val Leu Ala Gly
        115                 120                 125             
Lys Gln Glu Glu Ser Gly Val Lys Leu Leu Trp Gly Thr Ala Asn Cys
    130                 135                 140                 
Phe Thr Asn Pro Arg Tyr Gly Ala Gly Ala Ala Thr Asn Pro Asp Pro
145                 150                 155                 160 
Glu Val Phe Ser Trp Ala Ala Thr Gln Val Val Thr Ala Met Glu Ala
                165                 170                 175     
Thr His Lys Leu Gly Gly Glu Asn Tyr Val Leu Trp Gly Gly Arg Glu
            180                 185                 190         
Gly Tyr Glu Thr Leu Leu Asn Thr Asp Leu Arg Gln Glu Arg Glu Gln
        195                 200                 205             
Leu Gly Arg Phe Met Gln Met Val Val Glu His Lys His Lys Ile Gly
    210                 215                 220                 
Phe Gln Gly Thr Leu Leu Ile Glu Pro Lys Pro Gln Glu Pro Thr Lys
225                 230                 235                 240 
His Gln Tyr Asp Tyr Asp Ala Ala Thr Val Tyr Gly Phe Leu Lys Gln
                245                 250                 255     
Phe Gly Leu Glu Lys Glu Ile Lys Leu Asn Ile Glu Ala Asn His Ala
            260                 265                 270         
Thr Leu Ala Gly His Ser Phe His His Glu Ile Ala Thr Ala Ile Ala
        275                 280                 285             
Leu Gly Leu Phe Gly Ser Val Asp Ala Asn Arg Gly Asp Ala Gln Leu
    290                 295                 300                 
Gly Trp Asp Thr Asp Gln Phe Pro Asn Ser Val Glu Glu Asn Ala Leu
305                 310                 315                 320 
Val Met Tyr Glu Ile Leu Lys Ala Gly Gly Phe Thr Thr Gly Gly Leu
                325                 330                 335     
Asn Phe Asp Ala Lys Val Arg Arg Gln Ser Thr Asp Lys Tyr Asp Leu
            340                 345                 350         
Phe Tyr Gly His Ile Gly Ala Met Asp Thr Met Ala Leu Ala Leu Lys
        355                 360                 365             
Ile Ala Ala Arg Met Ile Glu Asp Gly Glu Leu Asp Lys Arg Ile Ala
    370                 375                 380                 
Gln Arg Tyr Ser Gly Trp Asn Ser Glu Leu Gly Gln Gln Ile Leu Lys
385                 390                 395                 400 
Gly Gln Met Ser Leu Ala Asp Leu Ala Lys Tyr Ala Gln Glu His His
                405                 410                 415     
Leu Ser Pro Val His Gln Ser Gly Arg Gln Glu Gln Leu Glu Asn Leu
            420                 425                 430         
Val Asn His Tyr Leu Phe Asp Lys
        435                 440 


<210> 185
<211> 1342
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in P. pastoris

<220> 
<221> CDS            
<222> (12)...(1331)

<400> 185
tactcaagct t atg cag gct tat ttt gat caa ttg gat aga gtt aga tat  50
             Met Gln Ala Tyr Phe Asp Gln Leu Asp Arg Val Arg Tyr
              1               5                   10
 
gaa gga tct aaa tct tct aat cca ttg gct ttt aga cat tat aat cca   98
Glu Gly Ser Lys Ser Ser Asn Pro Leu Ala Phe Arg His Tyr Asn Pro
     15                  20                  25
 
gat gaa ttg gtt ttg gga aaa aga atg gaa gaa cat ttg aga ttt gca   146
Asp Glu Leu Val Leu Gly Lys Arg Met Glu Glu His Leu Arg Phe Ala
 30                  35                  40                  45
 
gct tgt tat tgg cat act ttt tgt tgg aat gga gct gat atg ttt ggt   194
Ala Cys Tyr Trp His Thr Phe Cys Trp Asn Gly Ala Asp Met Phe Gly
                 50                  55                  60
 
gtg gga gct ttt aat aga cca tgg caa caa cca gga gag gct ctt gct   242
Val Gly Ala Phe Asn Arg Pro Trp Gln Gln Pro Gly Glu Ala Leu Ala
             65                  70                  75
 
tta gct aag aga aag gcc gat gtt gca ttc gag ttc ttt cat aaa ttg   290
Leu Ala Lys Arg Lys Ala Asp Val Ala Phe Glu Phe Phe His Lys Leu
         80                  85                  90
 
cat gtt cca ttt tat tgt ttt cat gat gtg gat gtt tct cca gaa ggt   338
His Val Pro Phe Tyr Cys Phe His Asp Val Asp Val Ser Pro Glu Gly
     95                 100                 105
 
gca tct tta aaa gaa tat att aat aat ttc gct caa atg gtt gat gtt   386
Ala Ser Leu Lys Glu Tyr Ile Asn Asn Phe Ala Gln Met Val Asp Val
110                 115                 120                 125
 
ttg gct gga aaa caa gaa gaa tct gga gtt aaa tta tta tgg ggc act   434
Leu Ala Gly Lys Gln Glu Glu Ser Gly Val Lys Leu Leu Trp Gly Thr
                130                 135                 140
 
gct aat tgt ttt act aat cct aga tac ggt gct gga gct gca act aat   482
Ala Asn Cys Phe Thr Asn Pro Arg Tyr Gly Ala Gly Ala Ala Thr Asn
            145                 150                 155
 
cct gat cct gaa gtt ttc tct tgg gct gct act caa gtt gtt act gct   530
Pro Asp Pro Glu Val Phe Ser Trp Ala Ala Thr Gln Val Val Thr Ala
        160                 165                 170
 
atg gaa gct aca cat aaa tta gga gga gaa aat tat gtt ttg tgg gga   578
Met Glu Ala Thr His Lys Leu Gly Gly Glu Asn Tyr Val Leu Trp Gly
    175                 180                 185
 
ggt aga gaa gga tat gaa aca ttg tta aat act gat ttg aga caa gaa   626
Gly Arg Glu Gly Tyr Glu Thr Leu Leu Asn Thr Asp Leu Arg Gln Glu
190                 195                 200                 205
 
aga gaa caa ttg ggt aga ttt atg caa atg gtt gtt gaa cat aaa cat   674
Arg Glu Gln Leu Gly Arg Phe Met Gln Met Val Val Glu His Lys His
                210                 215                 220
 
aaa att gga ttt caa gga aca ttg ttg att gaa cca aag cca caa gaa   722
Lys Ile Gly Phe Gln Gly Thr Leu Leu Ile Glu Pro Lys Pro Gln Glu
            225                 230                 235
 
cca act aaa cat caa tat gat tat gat gct gct act gtt tat gga ttt   770
Pro Thr Lys His Gln Tyr Asp Tyr Asp Ala Ala Thr Val Tyr Gly Phe
        240                 245                 250
 
tta aaa caa ttt ggt tta gaa aaa gaa att aaa tta aac att gaa gct   818
Leu Lys Gln Phe Gly Leu Glu Lys Glu Ile Lys Leu Asn Ile Glu Ala
    255                 260                 265
 
aat cat gct aca ttg gct gga cat tct ttt cat cat gaa atc gct act   866
Asn His Ala Thr Leu Ala Gly His Ser Phe His His Glu Ile Ala Thr
270                 275                 280                 285
 
gct att gct tta gga ttg ttt ggt tct gtt gat gct aat aga gga gat   914
Ala Ile Ala Leu Gly Leu Phe Gly Ser Val Asp Ala Asn Arg Gly Asp
                290                 295                 300
 
gct caa ttg gga tgg gat act gat caa ttt cca aat tct gtt gaa gaa   962
Ala Gln Leu Gly Trp Asp Thr Asp Gln Phe Pro Asn Ser Val Glu Glu
            305                 310                 315
 
aat gca ttg gtt atg tat gaa att ttg aag gct gga gga ttt act act   1010
Asn Ala Leu Val Met Tyr Glu Ile Leu Lys Ala Gly Gly Phe Thr Thr
        320                 325                 330
 
gga gga tta aat ttt gat gct aaa gtt aga aga caa tct act gat aaa   1058
Gly Gly Leu Asn Phe Asp Ala Lys Val Arg Arg Gln Ser Thr Asp Lys
    335                 340                 345
 
tat gat ttg ttt tat gga cat att gga gct atg gat act atg gct ttg   1106
Tyr Asp Leu Phe Tyr Gly His Ile Gly Ala Met Asp Thr Met Ala Leu
350                 355                 360                 365
 
gct tta aaa att gct gct aga atg att gaa gat gga gaa ttg gat aaa   1154
Ala Leu Lys Ile Ala Ala Arg Met Ile Glu Asp Gly Glu Leu Asp Lys
                370                 375                 380
 
aga att gct caa aga tat tct gga tgg aat agt gag ttg gga cag caa   1202
Arg Ile Ala Gln Arg Tyr Ser Gly Trp Asn Ser Glu Leu Gly Gln Gln
            385                 390                 395
 
att tta aaa gga caa atg tct tta gca gat ttg gca aag tac gct caa   1250
Ile Leu Lys Gly Gln Met Ser Leu Ala Asp Leu Ala Lys Tyr Ala Gln
        400                 405                 410
 
gaa cat cat ttg tct cca gtt cat caa tca ggt aga caa gaa caa tta   1298
Glu His His Leu Ser Pro Val His Gln Ser Gly Arg Gln Glu Gln Leu
    415                 420                 425
 
gaa aat ttg gtt aat cat tat tta ttt gat aaa gaattccgat g          1342
Glu Asn Leu Val Asn His Tyr Leu Phe Asp Lys
430                 435                 440
 

<210> 186
<211> 440
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in P. pastoris

<400> 186
Met Gln Ala Tyr Phe Asp Gln Leu Asp Arg Val Arg Tyr Glu Gly Ser
 1               5                  10                  15      
Lys Ser Ser Asn Pro Leu Ala Phe Arg His Tyr Asn Pro Asp Glu Leu
            20                  25                  30          
Val Leu Gly Lys Arg Met Glu Glu His Leu Arg Phe Ala Ala Cys Tyr
        35                  40                  45              
Trp His Thr Phe Cys Trp Asn Gly Ala Asp Met Phe Gly Val Gly Ala
    50                  55                  60                  
Phe Asn Arg Pro Trp Gln Gln Pro Gly Glu Ala Leu Ala Leu Ala Lys
65                  70                  75                  80  
Arg Lys Ala Asp Val Ala Phe Glu Phe Phe His Lys Leu His Val Pro
                85                  90                  95      
Phe Tyr Cys Phe His Asp Val Asp Val Ser Pro Glu Gly Ala Ser Leu
            100                 105                 110         
Lys Glu Tyr Ile Asn Asn Phe Ala Gln Met Val Asp Val Leu Ala Gly
        115                 120                 125             
Lys Gln Glu Glu Ser Gly Val Lys Leu Leu Trp Gly Thr Ala Asn Cys
    130                 135                 140                 
Phe Thr Asn Pro Arg Tyr Gly Ala Gly Ala Ala Thr Asn Pro Asp Pro
145                 150                 155                 160 
Glu Val Phe Ser Trp Ala Ala Thr Gln Val Val Thr Ala Met Glu Ala
                165                 170                 175     
Thr His Lys Leu Gly Gly Glu Asn Tyr Val Leu Trp Gly Gly Arg Glu
            180                 185                 190         
Gly Tyr Glu Thr Leu Leu Asn Thr Asp Leu Arg Gln Glu Arg Glu Gln
        195                 200                 205             
Leu Gly Arg Phe Met Gln Met Val Val Glu His Lys His Lys Ile Gly
    210                 215                 220                 
Phe Gln Gly Thr Leu Leu Ile Glu Pro Lys Pro Gln Glu Pro Thr Lys
225                 230                 235                 240 
His Gln Tyr Asp Tyr Asp Ala Ala Thr Val Tyr Gly Phe Leu Lys Gln
                245                 250                 255     
Phe Gly Leu Glu Lys Glu Ile Lys Leu Asn Ile Glu Ala Asn His Ala
            260                 265                 270         
Thr Leu Ala Gly His Ser Phe His His Glu Ile Ala Thr Ala Ile Ala
        275                 280                 285             
Leu Gly Leu Phe Gly Ser Val Asp Ala Asn Arg Gly Asp Ala Gln Leu
    290                 295                 300                 
Gly Trp Asp Thr Asp Gln Phe Pro Asn Ser Val Glu Glu Asn Ala Leu
305                 310                 315                 320 
Val Met Tyr Glu Ile Leu Lys Ala Gly Gly Phe Thr Thr Gly Gly Leu
                325                 330                 335     
Asn Phe Asp Ala Lys Val Arg Arg Gln Ser Thr Asp Lys Tyr Asp Leu
            340                 345                 350         
Phe Tyr Gly His Ile Gly Ala Met Asp Thr Met Ala Leu Ala Leu Lys
        355                 360                 365             
Ile Ala Ala Arg Met Ile Glu Asp Gly Glu Leu Asp Lys Arg Ile Ala
    370                 375                 380                 
Gln Arg Tyr Ser Gly Trp Asn Ser Glu Leu Gly Gln Gln Ile Leu Lys
385                 390                 395                 400 
Gly Gln Met Ser Leu Ala Asp Leu Ala Lys Tyr Ala Gln Glu His His
                405                 410                 415     
Leu Ser Pro Val His Gln Ser Gly Arg Gln Glu Gln Leu Glu Asn Leu
            420                 425                 430         
Val Asn His Tyr Leu Phe Asp Lys
        435                 440 


<210> 187
<211> 1348
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in P. pastoris

<220> 
<221> CDS            
<222> (15)...(1334)

<400> 187
gaatactcca tatg atg cag gct tat ttt gat caa ttg gat aga gtt aga   50
                Met Gln Ala Tyr Phe Asp Gln Leu Asp Arg Val Arg
                 1               5                   10
 
tat gaa gga tct aaa tct tct aat cca ttg gct ttt aga cat tat aat   98
Tyr Glu Gly Ser Lys Ser Ser Asn Pro Leu Ala Phe Arg His Tyr Asn
         15                  20                  25
 
cca gat gaa ttg gtt ttg gga aaa aga atg gaa gaa cat ttg aga ttt   146
Pro Asp Glu Leu Val Leu Gly Lys Arg Met Glu Glu His Leu Arg Phe
     30                  35                  40
 
gca gct tgt tat tgg cat act ttt tgt tgg aat gga gct gat atg ttt   194
Ala Ala Cys Tyr Trp His Thr Phe Cys Trp Asn Gly Ala Asp Met Phe
 45                  50                  55                  60
 
ggt gtg gga gct ttt aat aga cca tgg caa caa cca gga gag gct ctt   242
Gly Val Gly Ala Phe Asn Arg Pro Trp Gln Gln Pro Gly Glu Ala Leu
                 65                  70                  75
 
gct tta gct aag aga aag gcc gat gtt gca ttc gag ttc ttt cat aaa   290
Ala Leu Ala Lys Arg Lys Ala Asp Val Ala Phe Glu Phe Phe His Lys
             80                  85                  90
 
ttg cat gtt cca ttt tat tgt ttt cat gat gtg gat gtt tct cca gaa   338
Leu His Val Pro Phe Tyr Cys Phe His Asp Val Asp Val Ser Pro Glu
         95                 100                 105
 
ggt gca tct tta aaa gaa tat att aat aat ttc gct caa atg gtt gat   386
Gly Ala Ser Leu Lys Glu Tyr Ile Asn Asn Phe Ala Gln Met Val Asp
    110                 115                 120
 
gtt ttg gct gga aaa caa gaa gaa tct gga gtt aaa tta tta tgg ggc   434
Val Leu Ala Gly Lys Gln Glu Glu Ser Gly Val Lys Leu Leu Trp Gly
125                 130                 135                 140
 
act gct aat tgt ttt act aat cct aga tac ggt gct gga gct gca act   482
Thr Ala Asn Cys Phe Thr Asn Pro Arg Tyr Gly Ala Gly Ala Ala Thr
                145                 150                 155
 
aat cct gat cct gaa gtt ttc tct tgg gct gct act caa gtt gtt act   530
Asn Pro Asp Pro Glu Val Phe Ser Trp Ala Ala Thr Gln Val Val Thr
            160                 165                 170
 
gct atg gaa gct aca cat aaa tta gga gga gaa aat tat gtt ttg tgg   578
Ala Met Glu Ala Thr His Lys Leu Gly Gly Glu Asn Tyr Val Leu Trp
        175                 180                 185
 
gga ggt aga gaa gga tat gaa aca ttg tta aat act gat ttg aga caa   626
Gly Gly Arg Glu Gly Tyr Glu Thr Leu Leu Asn Thr Asp Leu Arg Gln
    190                 195                 200
 
gaa aga gaa caa ttg ggt aga ttt atg caa atg gtt gtt gaa cat aaa   674
Glu Arg Glu Gln Leu Gly Arg Phe Met Gln Met Val Val Glu His Lys
205                 210                 215                 220
 
cat aaa att gga ttt caa gga aca ttg ttg att gaa cca aag cca caa   722
His Lys Ile Gly Phe Gln Gly Thr Leu Leu Ile Glu Pro Lys Pro Gln
                225                 230                 235
 
gaa cca act aaa cat caa tat gat tat gat gct gct act gtt tat gga   770
Glu Pro Thr Lys His Gln Tyr Asp Tyr Asp Ala Ala Thr Val Tyr Gly
            240                 245                 250
 
ttt tta aaa caa ttt ggt tta gaa aaa gaa att aaa tta aac att gaa   818
Phe Leu Lys Gln Phe Gly Leu Glu Lys Glu Ile Lys Leu Asn Ile Glu
        255                 260                 265
 
gct aat cat gct aca ttg gct gga cat tct ttt cat cat gaa atc gct   866
Ala Asn His Ala Thr Leu Ala Gly His Ser Phe His His Glu Ile Ala
    270                 275                 280
 
act gct att gct tta gga ttg ttt ggt tct gtt gat gct aat aga gga   914
Thr Ala Ile Ala Leu Gly Leu Phe Gly Ser Val Asp Ala Asn Arg Gly
285                 290                 295                 300
 
gat gct caa ttg gga tgg gat act gat caa ttt cca aat tct gtt gaa   962
Asp Ala Gln Leu Gly Trp Asp Thr Asp Gln Phe Pro Asn Ser Val Glu
                305                 310                 315
 
gaa aat gca ttg gtt atg tat gaa att ttg aag gct gga gga ttt act   1010
Glu Asn Ala Leu Val Met Tyr Glu Ile Leu Lys Ala Gly Gly Phe Thr
            320                 325                 330
 
act gga gga tta aat ttt gat gct aaa gtt aga aga caa tct act gat   1058
Thr Gly Gly Leu Asn Phe Asp Ala Lys Val Arg Arg Gln Ser Thr Asp
        335                 340                 345
 
aaa tat gat ttg ttt tat gga cat att gga gct atg gat act atg gct   1106
Lys Tyr Asp Leu Phe Tyr Gly His Ile Gly Ala Met Asp Thr Met Ala
    350                 355                 360
 
ttg gct tta aaa att gct gct aga atg att gaa gat gga gaa ttg gat   1154
Leu Ala Leu Lys Ile Ala Ala Arg Met Ile Glu Asp Gly Glu Leu Asp
365                 370                 375                 380
 
aaa aga att gct caa aga tat tct gga tgg aat agt gag ttg gga cag   1202
Lys Arg Ile Ala Gln Arg Tyr Ser Gly Trp Asn Ser Glu Leu Gly Gln
                385                 390                 395
 
caa att tta aaa gga caa atg tct tta gca gat ttg gca aag tac gct   1250
Gln Ile Leu Lys Gly Gln Met Ser Leu Ala Asp Leu Ala Lys Tyr Ala
            400                 405                 410
 
caa gaa cat cat ttg tct cca gtt cat caa tca ggt aga caa gaa caa   1298
Gln Glu His His Leu Ser Pro Val His Gln Ser Gly Arg Gln Glu Gln
        415                 420                 425
 
tta gaa aat ttg gtt aat cat tat tta ttt gat aaa actagtcgat        1344
Leu Glu Asn Leu Val Asn His Tyr Leu Phe Asp Lys
    430                 435                 440
 
gcct                                                              1348

<210> 188
<211> 440
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in P. pastoris

<400> 188
Met Gln Ala Tyr Phe Asp Gln Leu Asp Arg Val Arg Tyr Glu Gly Ser
 1               5                  10                  15      
Lys Ser Ser Asn Pro Leu Ala Phe Arg His Tyr Asn Pro Asp Glu Leu
            20                  25                  30          
Val Leu Gly Lys Arg Met Glu Glu His Leu Arg Phe Ala Ala Cys Tyr
        35                  40                  45              
Trp His Thr Phe Cys Trp Asn Gly Ala Asp Met Phe Gly Val Gly Ala
    50                  55                  60                  
Phe Asn Arg Pro Trp Gln Gln Pro Gly Glu Ala Leu Ala Leu Ala Lys
65                  70                  75                  80  
Arg Lys Ala Asp Val Ala Phe Glu Phe Phe His Lys Leu His Val Pro
                85                  90                  95      
Phe Tyr Cys Phe His Asp Val Asp Val Ser Pro Glu Gly Ala Ser Leu
            100                 105                 110         
Lys Glu Tyr Ile Asn Asn Phe Ala Gln Met Val Asp Val Leu Ala Gly
        115                 120                 125             
Lys Gln Glu Glu Ser Gly Val Lys Leu Leu Trp Gly Thr Ala Asn Cys
    130                 135                 140                 
Phe Thr Asn Pro Arg Tyr Gly Ala Gly Ala Ala Thr Asn Pro Asp Pro
145                 150                 155                 160 
Glu Val Phe Ser Trp Ala Ala Thr Gln Val Val Thr Ala Met Glu Ala
                165                 170                 175     
Thr His Lys Leu Gly Gly Glu Asn Tyr Val Leu Trp Gly Gly Arg Glu
            180                 185                 190         
Gly Tyr Glu Thr Leu Leu Asn Thr Asp Leu Arg Gln Glu Arg Glu Gln
        195                 200                 205             
Leu Gly Arg Phe Met Gln Met Val Val Glu His Lys His Lys Ile Gly
    210                 215                 220                 
Phe Gln Gly Thr Leu Leu Ile Glu Pro Lys Pro Gln Glu Pro Thr Lys
225                 230                 235                 240 
His Gln Tyr Asp Tyr Asp Ala Ala Thr Val Tyr Gly Phe Leu Lys Gln
                245                 250                 255     
Phe Gly Leu Glu Lys Glu Ile Lys Leu Asn Ile Glu Ala Asn His Ala
            260                 265                 270         
Thr Leu Ala Gly His Ser Phe His His Glu Ile Ala Thr Ala Ile Ala
        275                 280                 285             
Leu Gly Leu Phe Gly Ser Val Asp Ala Asn Arg Gly Asp Ala Gln Leu
    290                 295                 300                 
Gly Trp Asp Thr Asp Gln Phe Pro Asn Ser Val Glu Glu Asn Ala Leu
305                 310                 315                 320 
Val Met Tyr Glu Ile Leu Lys Ala Gly Gly Phe Thr Thr Gly Gly Leu
                325                 330                 335     
Asn Phe Asp Ala Lys Val Arg Arg Gln Ser Thr Asp Lys Tyr Asp Leu
            340                 345                 350         
Phe Tyr Gly His Ile Gly Ala Met Asp Thr Met Ala Leu Ala Leu Lys
        355                 360                 365             
Ile Ala Ala Arg Met Ile Glu Asp Gly Glu Leu Asp Lys Arg Ile Ala
    370                 375                 380                 
Gln Arg Tyr Ser Gly Trp Asn Ser Glu Leu Gly Gln Gln Ile Leu Lys
385                 390                 395                 400 
Gly Gln Met Ser Leu Ala Asp Leu Ala Lys Tyr Ala Gln Glu His His
                405                 410                 415     
Leu Ser Pro Val His Gln Ser Gly Arg Gln Glu Gln Leu Glu Asn Leu
            420                 425                 430         
Val Asn His Tyr Leu Phe Asp Lys
        435                 440 


<210> 189
<211> 1320
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in K. lactis

<220> 
<221> CDS            
<222> (1)...(1320)

<400> 189
atg cag gct tat ttt gat caa ttg gat aga gtt aga tat gaa ggt agt   48
Met Gln Ala Tyr Phe Asp Gln Leu Asp Arg Val Arg Tyr Glu Gly Ser
 1               5                   10                  15
 
aaa tct tct aat cca ttg gct ttc aga cat tat aat cca gat gaa ttg   96
Lys Ser Ser Asn Pro Leu Ala Phe Arg His Tyr Asn Pro Asp Glu Leu
             20                  25                  30
 
gtt ttg gga aaa aga atg gaa gaa cat ttg aga ttc gct gct tgt tat   144
Val Leu Gly Lys Arg Met Glu Glu His Leu Arg Phe Ala Ala Cys Tyr
         35                  40                  45
 
tgg cat act ttc tgt tgg aat ggt gct gat atg ttc ggt gtt ggt gca   192
Trp His Thr Phe Cys Trp Asn Gly Ala Asp Met Phe Gly Val Gly Ala
     50                  55                  60
 
ttc aat aga cca tgg caa caa cca ggc gaa gca tta gca ctc gct aaa   240
Phe Asn Arg Pro Trp Gln Gln Pro Gly Glu Ala Leu Ala Leu Ala Lys
 65                  70                  75                  80
 
aga aaa gct gat gtt gct ttc gaa ttt ttc cac aaa ttg cat gtt cca   288
Arg Lys Ala Asp Val Ala Phe Glu Phe Phe His Lys Leu His Val Pro
                 85                  90                  95
 
ttc tat tgt ttc cac gat gtt gat gtt tct cct gaa ggt gct agt tta   336
Phe Tyr Cys Phe His Asp Val Asp Val Ser Pro Glu Gly Ala Ser Leu
            100                 105                 110
 
aaa gaa tat att aat aat ttc gct caa atg gta gat gta cta gct ggt   384
Lys Glu Tyr Ile Asn Asn Phe Ala Gln Met Val Asp Val Leu Ala Gly
        115                 120                 125
 
aag caa gaa gaa tct ggt gtt aaa ttg ttg tgg gga act gct aat tgt   432
Lys Gln Glu Glu Ser Gly Val Lys Leu Leu Trp Gly Thr Ala Asn Cys
    130                 135                 140
 
ttc act aat cca agg tat ggc gca gga gcc gct act aat cca gat cca   480
Phe Thr Asn Pro Arg Tyr Gly Ala Gly Ala Ala Thr Asn Pro Asp Pro
145                 150                 155                 160
 
gaa gtt ttc tct tgg gct gct aca caa gtt gtt act gct atg gaa gct   528
Glu Val Phe Ser Trp Ala Ala Thr Gln Val Val Thr Ala Met Glu Ala
                165                 170                 175
 
act cat aaa ttg ggt ggt gaa aat tat gtt ctc tgg gga gga agg gaa   576
Thr His Lys Leu Gly Gly Glu Asn Tyr Val Leu Trp Gly Gly Arg Glu
            180                 185                 190
 
ggt tat gag act tta tta aat act gat ttg aga caa gaa aga gaa caa   624
Gly Tyr Glu Thr Leu Leu Asn Thr Asp Leu Arg Gln Glu Arg Glu Gln
        195                 200                 205
 
ttg ggt aga ttc atg caa atg gtg gtc gaa cat aaa cat aaa att ggt   672
Leu Gly Arg Phe Met Gln Met Val Val Glu His Lys His Lys Ile Gly
    210                 215                 220
 
ttc cag ggt aca ttg ttg att gaa cca aag cca caa gaa cca act aaa   720
Phe Gln Gly Thr Leu Leu Ile Glu Pro Lys Pro Gln Glu Pro Thr Lys
225                 230                 235                 240
 
cat caa tat gat tat gat gct gca aca gtt tat ggt ttc tta aaa caa   768
His Gln Tyr Asp Tyr Asp Ala Ala Thr Val Tyr Gly Phe Leu Lys Gln
                245                 250                 255
 
ttc ggt ttg gaa aag gag att aaa tta aat att gaa gct aat cac gct   816
Phe Gly Leu Glu Lys Glu Ile Lys Leu Asn Ile Glu Ala Asn His Ala
            260                 265                 270
 
acc tta gct ggg cat tct ttc cac cac gaa atc gct aca gct att gct   864
Thr Leu Ala Gly His Ser Phe His His Glu Ile Ala Thr Ala Ile Ala
        275                 280                 285
 
ctt ggt ttg ttt gga tct gtt gac gca aat aga ggt gat gct caa cta   912
Leu Gly Leu Phe Gly Ser Val Asp Ala Asn Arg Gly Asp Ala Gln Leu
    290                 295                 300
 
gga tgg gat act gat caa ttt cca aat tct gtt gaa gaa aat gct tta   960
Gly Trp Asp Thr Asp Gln Phe Pro Asn Ser Val Glu Glu Asn Ala Leu
305                 310                 315                 320
 
gtt atg tat gaa att tta aaa gct gga ggt ttc act act ggt gga tta   1008
Val Met Tyr Glu Ile Leu Lys Ala Gly Gly Phe Thr Thr Gly Gly Leu
                325                 330                 335
 
aat ttc gat gct aaa gtt agg aga caa tct act gat aag tat gat ttg   1056
Asn Phe Asp Ala Lys Val Arg Arg Gln Ser Thr Asp Lys Tyr Asp Leu
            340                 345                 350
 
ttc tat ggt cat att gga gca atg gat act atg gct cta gct cta aaa   1104
Phe Tyr Gly His Ile Gly Ala Met Asp Thr Met Ala Leu Ala Leu Lys
        355                 360                 365
 
att gct gcg aga atg att gaa gat ggt gaa ttg gac aaa aga att gct   1152
Ile Ala Ala Arg Met Ile Glu Asp Gly Glu Leu Asp Lys Arg Ile Ala
    370                 375                 380
 
caa aga tat tct ggt tgg aac tct gaa ttg ggt cag caa att cta aaa   1200
Gln Arg Tyr Ser Gly Trp Asn Ser Glu Leu Gly Gln Gln Ile Leu Lys
385                 390                 395                 400
 
ggt caa atg tca ctt gcc gat ttg gct aaa tat gct caa gaa cac cac   1248
Gly Gln Met Ser Leu Ala Asp Leu Ala Lys Tyr Ala Gln Glu His His
                405                 410                 415
 
tta tca ccg gtt cat caa tct ggt aga cag gaa caa tta gaa aat ttg   1296
Leu Ser Pro Val His Gln Ser Gly Arg Gln Glu Gln Leu Glu Asn Leu
            420                 425                 430
 
gtt aat cat tat tta ttc gac aaa                                   1320
Val Asn His Tyr Leu Phe Asp Lys
        435                 440
 

<210> 190
<211> 440
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in K. lactis

<400> 190
Met Gln Ala Tyr Phe Asp Gln Leu Asp Arg Val Arg Tyr Glu Gly Ser
 1               5                  10                  15      
Lys Ser Ser Asn Pro Leu Ala Phe Arg His Tyr Asn Pro Asp Glu Leu
            20                  25                  30          
Val Leu Gly Lys Arg Met Glu Glu His Leu Arg Phe Ala Ala Cys Tyr
        35                  40                  45              
Trp His Thr Phe Cys Trp Asn Gly Ala Asp Met Phe Gly Val Gly Ala
    50                  55                  60                  
Phe Asn Arg Pro Trp Gln Gln Pro Gly Glu Ala Leu Ala Leu Ala Lys
65                  70                  75                  80  
Arg Lys Ala Asp Val Ala Phe Glu Phe Phe His Lys Leu His Val Pro
                85                  90                  95      
Phe Tyr Cys Phe His Asp Val Asp Val Ser Pro Glu Gly Ala Ser Leu
            100                 105                 110         
Lys Glu Tyr Ile Asn Asn Phe Ala Gln Met Val Asp Val Leu Ala Gly
        115                 120                 125             
Lys Gln Glu Glu Ser Gly Val Lys Leu Leu Trp Gly Thr Ala Asn Cys
    130                 135                 140                 
Phe Thr Asn Pro Arg Tyr Gly Ala Gly Ala Ala Thr Asn Pro Asp Pro
145                 150                 155                 160 
Glu Val Phe Ser Trp Ala Ala Thr Gln Val Val Thr Ala Met Glu Ala
                165                 170                 175     
Thr His Lys Leu Gly Gly Glu Asn Tyr Val Leu Trp Gly Gly Arg Glu
            180                 185                 190         
Gly Tyr Glu Thr Leu Leu Asn Thr Asp Leu Arg Gln Glu Arg Glu Gln
        195                 200                 205             
Leu Gly Arg Phe Met Gln Met Val Val Glu His Lys His Lys Ile Gly
    210                 215                 220                 
Phe Gln Gly Thr Leu Leu Ile Glu Pro Lys Pro Gln Glu Pro Thr Lys
225                 230                 235                 240 
His Gln Tyr Asp Tyr Asp Ala Ala Thr Val Tyr Gly Phe Leu Lys Gln
                245                 250                 255     
Phe Gly Leu Glu Lys Glu Ile Lys Leu Asn Ile Glu Ala Asn His Ala
            260                 265                 270         
Thr Leu Ala Gly His Ser Phe His His Glu Ile Ala Thr Ala Ile Ala
        275                 280                 285             
Leu Gly Leu Phe Gly Ser Val Asp Ala Asn Arg Gly Asp Ala Gln Leu
    290                 295                 300                 
Gly Trp Asp Thr Asp Gln Phe Pro Asn Ser Val Glu Glu Asn Ala Leu
305                 310                 315                 320 
Val Met Tyr Glu Ile Leu Lys Ala Gly Gly Phe Thr Thr Gly Gly Leu
                325                 330                 335     
Asn Phe Asp Ala Lys Val Arg Arg Gln Ser Thr Asp Lys Tyr Asp Leu
            340                 345                 350         
Phe Tyr Gly His Ile Gly Ala Met Asp Thr Met Ala Leu Ala Leu Lys
        355                 360                 365             
Ile Ala Ala Arg Met Ile Glu Asp Gly Glu Leu Asp Lys Arg Ile Ala
    370                 375                 380                 
Gln Arg Tyr Ser Gly Trp Asn Ser Glu Leu Gly Gln Gln Ile Leu Lys
385                 390                 395                 400 
Gly Gln Met Ser Leu Ala Asp Leu Ala Lys Tyr Ala Gln Glu His His
                405                 410                 415     
Leu Ser Pro Val His Gln Ser Gly Arg Gln Glu Gln Leu Glu Asn Leu
            420                 425                 430         
Val Asn His Tyr Leu Phe Asp Lys
        435                 440 


<210> 191
<211> 1320
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in Z. mobilis

<220> 
<221> CDS            
<222> (1)...(1320)

<400> 191
atg cag gct tat ttt gat cag ttg gat cgt gtt cgt tat gaa ggt tct   48
Met Gln Ala Tyr Phe Asp Gln Leu Asp Arg Val Arg Tyr Glu Gly Ser
 1               5                   10                  15
 
aaa tct tct aat ccg ttg gcg ttt cgt cat tat aat ccg gat gaa ttg   96
Lys Ser Ser Asn Pro Leu Ala Phe Arg His Tyr Asn Pro Asp Glu Leu
             20                  25                  30
 
gtt ttg ggt aaa cgt atg gaa gaa cat ttg cgt ttt gcc gct tgt tat   144
Val Leu Gly Lys Arg Met Glu Glu His Leu Arg Phe Ala Ala Cys Tyr
         35                  40                  45
 
tgg cat acc ttt tgt tgg aat ggt gcc gat atg ttt ggt gtt ggt gct   192
Trp His Thr Phe Cys Trp Asn Gly Ala Asp Met Phe Gly Val Gly Ala
     50                  55                  60
 
ttc aat cgt ccg tgg cag caa cct gga gag gcg ttg gcc ctt gct aaa   240
Phe Asn Arg Pro Trp Gln Gln Pro Gly Glu Ala Leu Ala Leu Ala Lys
 65                  70                  75                  80
 
cgt aaa gcc gat gtt gcc ttc gaa ttt ttc cat aaa ttg cat gtt ccg   288
Arg Lys Ala Asp Val Ala Phe Glu Phe Phe His Lys Leu His Val Pro
                 85                  90                  95
 
ttt tat tgt ttt cat gat gtt gat gtt tct ccg gaa ggt gcc tct ttg   336
Phe Tyr Cys Phe His Asp Val Asp Val Ser Pro Glu Gly Ala Ser Leu
            100                 105                 110
 
aag gag tat att aat aat ttt gcc cag atg gtt gat gtt ttg gct ggt   384
Lys Glu Tyr Ile Asn Asn Phe Ala Gln Met Val Asp Val Leu Ala Gly
        115                 120                 125
 
aaa cag gaa gaa tct ggt gtt aaa ttg ttg tgg ggc acc gct aat tgt   432
Lys Gln Glu Glu Ser Gly Val Lys Leu Leu Trp Gly Thr Ala Asn Cys
    130                 135                 140
 
ttt acg aat ccg cgt tat gga gct ggc gct gcg act aac ccc gat cca   480
Phe Thr Asn Pro Arg Tyr Gly Ala Gly Ala Ala Thr Asn Pro Asp Pro
145                 150                 155                 160
 
gaa gtc ttt tct tgg gcc gcc aca caa gtt gtt acc gcc atg gaa gct   528
Glu Val Phe Ser Trp Ala Ala Thr Gln Val Val Thr Ala Met Glu Ala
                165                 170                 175
 
acg cat aaa ttg gga gga gaa aat tat gtt ctg tgg ggt ggt cgt gaa   576
Thr His Lys Leu Gly Gly Glu Asn Tyr Val Leu Trp Gly Gly Arg Glu
            180                 185                 190
 
ggt tat gaa acc ttg ttg aat acc gat ttg cgt cag gaa cgt gaa cag   624
Gly Tyr Glu Thr Leu Leu Asn Thr Asp Leu Arg Gln Glu Arg Glu Gln
        195                 200                 205
 
ttg ggt aga ttt atg cag atg gtc gtt gaa cat aaa cat aaa att ggt   672
Leu Gly Arg Phe Met Gln Met Val Val Glu His Lys His Lys Ile Gly
    210                 215                 220
 
ttt cag ggc aca ctc ttg att gaa ccg aaa ccg cag gaa ccg acc aag   720
Phe Gln Gly Thr Leu Leu Ile Glu Pro Lys Pro Gln Glu Pro Thr Lys
225                 230                 235                 240
 
cat cag tat gat tat gac gcc gca act gtt tat ggt ttt ctt aaa cag   768
His Gln Tyr Asp Tyr Asp Ala Ala Thr Val Tyr Gly Phe Leu Lys Gln
                245                 250                 255
 
ttt ggt ttg gaa aaa gaa att aaa ttg aat att gag gcc aac cat gct   816
Phe Gly Leu Glu Lys Glu Ile Lys Leu Asn Ile Glu Ala Asn His Ala
            260                 265                 270
 
acc ctg gct ggc cat agt ttt cat cat gag att gcc act gct atc gcc   864
Thr Leu Ala Gly His Ser Phe His His Glu Ile Ala Thr Ala Ile Ala
        275                 280                 285
 
ctt ggt ttg ttt ggt tct gtt gat gct aat cgc ggg gat gct cag tta   912
Leu Gly Leu Phe Gly Ser Val Asp Ala Asn Arg Gly Asp Ala Gln Leu
    290                 295                 300
 
ggg tgg gat acc gat cag ttt ccg aat agc gtt gaa gaa aat gcg tta   960
Gly Trp Asp Thr Asp Gln Phe Pro Asn Ser Val Glu Glu Asn Ala Leu
305                 310                 315                 320
 
gtt atg tat gaa att ttg aaa gct ggt ggt ttt acc acg gga ggc ttg   1008
Val Met Tyr Glu Ile Leu Lys Ala Gly Gly Phe Thr Thr Gly Gly Leu
                325                 330                 335
 
aat ttt gat gct aaa gtt cgt cgt cag tct acc gat aaa tat gat ttg   1056
Asn Phe Asp Ala Lys Val Arg Arg Gln Ser Thr Asp Lys Tyr Asp Leu
            340                 345                 350
 
ttt tat ggt cat att ggt gca atg gat acg atg gct cta gcg ctt aaa   1104
Phe Tyr Gly His Ile Gly Ala Met Asp Thr Met Ala Leu Ala Leu Lys
        355                 360                 365
 
att gct gct cgc atg ata gag gat ggt gaa ttg gat aaa cgt att gcc   1152
Ile Ala Ala Arg Met Ile Glu Asp Gly Glu Leu Asp Lys Arg Ile Ala
    370                 375                 380
 
caa cgg tat tct ggt tgg aat agc gaa ttg ggt caa cag att ttg aaa   1200
Gln Arg Tyr Ser Gly Trp Asn Ser Glu Leu Gly Gln Gln Ile Leu Lys
385                 390                 395                 400
 
ggt cag atg tct ttg gcc gat ttg gct aag tat gca caa gaa cat cat   1248
Gly Gln Met Ser Leu Ala Asp Leu Ala Lys Tyr Ala Gln Glu His His
                405                 410                 415
 
ttg tct ccg gtt cat cag tct ggt cgt caa gag caa ctt gaa aat ttg   1296
Leu Ser Pro Val His Gln Ser Gly Arg Gln Glu Gln Leu Glu Asn Leu
            420                 425                 430
 
gtt aat cat tat ttg ttt gat aaa                                   1320
Val Asn His Tyr Leu Phe Asp Lys
        435                 440
 

<210> 192
<211> 440
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in Z. mobilis

<400> 192
Met Gln Ala Tyr Phe Asp Gln Leu Asp Arg Val Arg Tyr Glu Gly Ser
 1               5                  10                  15      
Lys Ser Ser Asn Pro Leu Ala Phe Arg His Tyr Asn Pro Asp Glu Leu
            20                  25                  30          
Val Leu Gly Lys Arg Met Glu Glu His Leu Arg Phe Ala Ala Cys Tyr
        35                  40                  45              
Trp His Thr Phe Cys Trp Asn Gly Ala Asp Met Phe Gly Val Gly Ala
    50                  55                  60                  
Phe Asn Arg Pro Trp Gln Gln Pro Gly Glu Ala Leu Ala Leu Ala Lys
65                  70                  75                  80  
Arg Lys Ala Asp Val Ala Phe Glu Phe Phe His Lys Leu His Val Pro
                85                  90                  95      
Phe Tyr Cys Phe His Asp Val Asp Val Ser Pro Glu Gly Ala Ser Leu
            100                 105                 110         
Lys Glu Tyr Ile Asn Asn Phe Ala Gln Met Val Asp Val Leu Ala Gly
        115                 120                 125             
Lys Gln Glu Glu Ser Gly Val Lys Leu Leu Trp Gly Thr Ala Asn Cys
    130                 135                 140                 
Phe Thr Asn Pro Arg Tyr Gly Ala Gly Ala Ala Thr Asn Pro Asp Pro
145                 150                 155                 160 
Glu Val Phe Ser Trp Ala Ala Thr Gln Val Val Thr Ala Met Glu Ala
                165                 170                 175     
Thr His Lys Leu Gly Gly Glu Asn Tyr Val Leu Trp Gly Gly Arg Glu
            180                 185                 190         
Gly Tyr Glu Thr Leu Leu Asn Thr Asp Leu Arg Gln Glu Arg Glu Gln
        195                 200                 205             
Leu Gly Arg Phe Met Gln Met Val Val Glu His Lys His Lys Ile Gly
    210                 215                 220                 
Phe Gln Gly Thr Leu Leu Ile Glu Pro Lys Pro Gln Glu Pro Thr Lys
225                 230                 235                 240 
His Gln Tyr Asp Tyr Asp Ala Ala Thr Val Tyr Gly Phe Leu Lys Gln
                245                 250                 255     
Phe Gly Leu Glu Lys Glu Ile Lys Leu Asn Ile Glu Ala Asn His Ala
            260                 265                 270         
Thr Leu Ala Gly His Ser Phe His His Glu Ile Ala Thr Ala Ile Ala
        275                 280                 285             
Leu Gly Leu Phe Gly Ser Val Asp Ala Asn Arg Gly Asp Ala Gln Leu
    290                 295                 300                 
Gly Trp Asp Thr Asp Gln Phe Pro Asn Ser Val Glu Glu Asn Ala Leu
305                 310                 315                 320 
Val Met Tyr Glu Ile Leu Lys Ala Gly Gly Phe Thr Thr Gly Gly Leu
                325                 330                 335     
Asn Phe Asp Ala Lys Val Arg Arg Gln Ser Thr Asp Lys Tyr Asp Leu
            340                 345                 350         
Phe Tyr Gly His Ile Gly Ala Met Asp Thr Met Ala Leu Ala Leu Lys
        355                 360                 365             
Ile Ala Ala Arg Met Ile Glu Asp Gly Glu Leu Asp Lys Arg Ile Ala
    370                 375                 380                 
Gln Arg Tyr Ser Gly Trp Asn Ser Glu Leu Gly Gln Gln Ile Leu Lys
385                 390                 395                 400 
Gly Gln Met Ser Leu Ala Asp Leu Ala Lys Tyr Ala Gln Glu His His
                405                 410                 415     
Leu Ser Pro Val His Gln Ser Gly Arg Gln Glu Gln Leu Glu Asn Leu
            420                 425                 430         
Val Asn His Tyr Leu Phe Asp Lys
        435                 440 


<210> 193
<211> 1503
<212> DNA
<213> E. coli

<220> 
<221> CDS            
<222> (1)...(1503)

<400> 193
atg acg att ttt gat aat tat gaa gtg tgg ttt gtc att ggc agc cag   48
Met Thr Ile Phe Asp Asn Tyr Glu Val Trp Phe Val Ile Gly Ser Gln
 1               5                   10                  15
 
cat ctg tat ggc ccg gaa acc ctg cgt cag gtc acc caa cat gcc gag   96
His Leu Tyr Gly Pro Glu Thr Leu Arg Gln Val Thr Gln His Ala Glu
             20                  25                  30
 
cac gtt gtt aat gcg ctg aat acg gaa gcg aaa ctg ccc tgc aaa ctg   144
His Val Val Asn Ala Leu Asn Thr Glu Ala Lys Leu Pro Cys Lys Leu
         35                  40                  45
 
gtg ttg aaa ccg ctg ggc acc acg ccg gat gaa atc acc gct att tgc   192
Val Leu Lys Pro Leu Gly Thr Thr Pro Asp Glu Ile Thr Ala Ile Cys
     50                  55                  60
 
cgc gac gcg aat tac gac gat ccg tgc gct ggt ctg gtg gtg tgg ctg   240
Arg Asp Ala Asn Tyr Asp Asp Pro Cys Ala Gly Leu Val Val Trp Leu
 65                  70                  75                  80
 
cac acc ttc tcc ccg gcc aaa atg tgg atc aac ggc ctg acc atg ctc   288
His Thr Phe Ser Pro Ala Lys Met Trp Ile Asn Gly Leu Thr Met Leu
                 85                  90                  95
 
aac aaa ccg ttg ctg caa ttc cac acc cag ttc aac gcg gcg ctg ccg   336
Asn Lys Pro Leu Leu Gln Phe His Thr Gln Phe Asn Ala Ala Leu Pro
            100                 105                 110
 
tgg gac agt atc gat atg gac ttt atg aac ctg aac cag act gca cat   384
Trp Asp Ser Ile Asp Met Asp Phe Met Asn Leu Asn Gln Thr Ala His
        115                 120                 125
 
ggc ggt cgc gag ttc ggc ttc att ggc gcg cgt atg cgt cag caa cat   432
Gly Gly Arg Glu Phe Gly Phe Ile Gly Ala Arg Met Arg Gln Gln His
    130                 135                 140
 
gcc gtc gtt acc ggt cac tgg cag gat aaa caa gcc cat gag cgt atc   480
Ala Val Val Thr Gly His Trp Gln Asp Lys Gln Ala His Glu Arg Ile
145                 150                 155                 160
 
ggc tcc tgg atg cgt cag gcg gtt tct aaa cag gat acc cgt cat ctg   528
Gly Ser Trp Met Arg Gln Ala Val Ser Lys Gln Asp Thr Arg His Leu
                165                 170                 175
 
aaa gtc tgc cgt ttt ggc gat aac atg cgt gaa gtg gcg gtc acc gat   576
Lys Val Cys Arg Phe Gly Asp Asn Met Arg Glu Val Ala Val Thr Asp
            180                 185                 190
 
ggt gat aaa gtt gcc gca cag atc aag ttc ggt ttc tcc gtc aat acc   624
Gly Asp Lys Val Ala Ala Gln Ile Lys Phe Gly Phe Ser Val Asn Thr
        195                 200                 205
 
tgg gcg gtt ggc gat ctg gtg cag gtg gtg aac tcc atc agc gac ggc   672
Trp Ala Val Gly Asp Leu Val Gln Val Val Asn Ser Ile Ser Asp Gly
    210                 215                 220
 
gat gtt aac gcg ctg gtc gat gag tac gaa agc tgc tac acc atg acg   720
Asp Val Asn Ala Leu Val Asp Glu Tyr Glu Ser Cys Tyr Thr Met Thr
225                 230                 235                 240
 
cct gca aca caa atc cac ggc gaa aaa cga cag aac gtg ctg gaa gcg   768
Pro Ala Thr Gln Ile His Gly Glu Lys Arg Gln Asn Val Leu Glu Ala
                245                 250                 255
 
gcg cgt att gag ctg ggg atg aag cgt ttc ctg gaa caa ggt ggc ttc   816
Ala Arg Ile Glu Leu Gly Met Lys Arg Phe Leu Glu Gln Gly Gly Phe
            260                 265                 270
 
cac gcg ttc acc acc acc ttt gaa gat ttg cac ggt ctg aaa cag ctt   864
His Ala Phe Thr Thr Thr Phe Glu Asp Leu His Gly Leu Lys Gln Leu
        275                 280                 285
 
cca ggt ctg gcc gta cag cgt ctg atg cag cag ggt tac ggc ttt gcg   912
Pro Gly Leu Ala Val Gln Arg Leu Met Gln Gln Gly Tyr Gly Phe Ala
    290                 295                 300
 
ggc gaa ggc gac tgg aaa acc gcc gcc ctg ctt cgc atc atg aag gtg   960
Gly Glu Gly Asp Trp Lys Thr Ala Ala Leu Leu Arg Ile Met Lys Val
305                 310                 315                 320
 
atg tca acc ggt ctg cag ggc ggc acc tcc ttt atg gag gac tac acc   1008
Met Ser Thr Gly Leu Gln Gly Gly Thr Ser Phe Met Glu Asp Tyr Thr
                325                 330                 335
 
tat cac ttc gag aaa ggt aat gac ttg gtg ctc ggc tcc cat atg ctg   1056
Tyr His Phe Glu Lys Gly Asn Asp Leu Val Leu Gly Ser His Met Leu
            340                 345                 350
 
gaa gtc tgc ccg tcg att gcc gta gaa gag aaa ccg atc ctc gac gtt   1104
Glu Val Cys Pro Ser Ile Ala Val Glu Glu Lys Pro Ile Leu Asp Val
        355                 360                 365
 
cag cat ctc ggt att ggt ggt aag gac gat cct gcc cga ctg atc ttc   1152
Gln His Leu Gly Ile Gly Gly Lys Asp Asp Pro Ala Arg Leu Ile Phe
    370                 375                 380
 
aat acc caa acc ggt cca gcg att gtc gcc agc ctg att gat ctc ggc   1200
Asn Thr Gln Thr Gly Pro Ala Ile Val Ala Ser Leu Ile Asp Leu Gly
385                 390                 395                 400
 
gat cgt tac cgt ctg ctg gtt aac tgt atc gac acg gtg aaa aca ccg   1248
Asp Arg Tyr Arg Leu Leu Val Asn Cys Ile Asp Thr Val Lys Thr Pro
                405                 410                 415
 
cac tcc ctg ccg aaa ctg ccg gtg gcg aat gcg ctg tgg aaa gcg caa   1296
His Ser Leu Pro Lys Leu Pro Val Ala Asn Ala Leu Trp Lys Ala Gln
            420                 425                 430
 
ccg gat ctg cca act gct tcc gaa gcg tgg atc ctc gct ggt ggc gcg   1344
Pro Asp Leu Pro Thr Ala Ser Glu Ala Trp Ile Leu Ala Gly Gly Ala
        435                 440                 445
 
cac cat acc gtc ttc agc cat gcg ctg aac ctc aac gat atg cgc cag   1392
His His Thr Val Phe Ser His Ala Leu Asn Leu Asn Asp Met Arg Gln
    450                 455                 460
 
ttc gcc gag atg cac gac att gaa atc acg gtg att gat aac gat acc   1440
Phe Ala Glu Met His Asp Ile Glu Ile Thr Val Ile Asp Asn Asp Thr
465                 470                 475                 480
 
cgc ctg cca gcg ttt aaa gac gcg ctg cgc tgg aac gaa gtg tat tac   1488
Arg Leu Pro Ala Phe Lys Asp Ala Leu Arg Trp Asn Glu Val Tyr Tyr
                485                 490                 495
 
gga ttt cgt cgc taa                                               1503
Gly Phe Arg Arg  *
            500
 

<210> 194
<211> 500
<212> PRT
<213> E. coli

<400> 194
Met Thr Ile Phe Asp Asn Tyr Glu Val Trp Phe Val Ile Gly Ser Gln
 1               5                  10                  15      
His Leu Tyr Gly Pro Glu Thr Leu Arg Gln Val Thr Gln His Ala Glu
            20                  25                  30          
His Val Val Asn Ala Leu Asn Thr Glu Ala Lys Leu Pro Cys Lys Leu
        35                  40                  45              
Val Leu Lys Pro Leu Gly Thr Thr Pro Asp Glu Ile Thr Ala Ile Cys
    50                  55                  60                  
Arg Asp Ala Asn Tyr Asp Asp Pro Cys Ala Gly Leu Val Val Trp Leu
65                  70                  75                  80  
His Thr Phe Ser Pro Ala Lys Met Trp Ile Asn Gly Leu Thr Met Leu
                85                  90                  95      
Asn Lys Pro Leu Leu Gln Phe His Thr Gln Phe Asn Ala Ala Leu Pro
            100                 105                 110         
Trp Asp Ser Ile Asp Met Asp Phe Met Asn Leu Asn Gln Thr Ala His
        115                 120                 125             
Gly Gly Arg Glu Phe Gly Phe Ile Gly Ala Arg Met Arg Gln Gln His
    130                 135                 140                 
Ala Val Val Thr Gly His Trp Gln Asp Lys Gln Ala His Glu Arg Ile
145                 150                 155                 160 
Gly Ser Trp Met Arg Gln Ala Val Ser Lys Gln Asp Thr Arg His Leu
                165                 170                 175     
Lys Val Cys Arg Phe Gly Asp Asn Met Arg Glu Val Ala Val Thr Asp
            180                 185                 190         
Gly Asp Lys Val Ala Ala Gln Ile Lys Phe Gly Phe Ser Val Asn Thr
        195                 200                 205             
Trp Ala Val Gly Asp Leu Val Gln Val Val Asn Ser Ile Ser Asp Gly
    210                 215                 220                 
Asp Val Asn Ala Leu Val Asp Glu Tyr Glu Ser Cys Tyr Thr Met Thr
225                 230                 235                 240 
Pro Ala Thr Gln Ile His Gly Glu Lys Arg Gln Asn Val Leu Glu Ala
                245                 250                 255     
Ala Arg Ile Glu Leu Gly Met Lys Arg Phe Leu Glu Gln Gly Gly Phe
            260                 265                 270         
His Ala Phe Thr Thr Thr Phe Glu Asp Leu His Gly Leu Lys Gln Leu
        275                 280                 285             
Pro Gly Leu Ala Val Gln Arg Leu Met Gln Gln Gly Tyr Gly Phe Ala
    290                 295                 300                 
Gly Glu Gly Asp Trp Lys Thr Ala Ala Leu Leu Arg Ile Met Lys Val
305                 310                 315                 320 
Met Ser Thr Gly Leu Gln Gly Gly Thr Ser Phe Met Glu Asp Tyr Thr
                325                 330                 335     
Tyr His Phe Glu Lys Gly Asn Asp Leu Val Leu Gly Ser His Met Leu
            340                 345                 350         
Glu Val Cys Pro Ser Ile Ala Val Glu Glu Lys Pro Ile Leu Asp Val
        355                 360                 365             
Gln His Leu Gly Ile Gly Gly Lys Asp Asp Pro Ala Arg Leu Ile Phe
    370                 375                 380                 
Asn Thr Gln Thr Gly Pro Ala Ile Val Ala Ser Leu Ile Asp Leu Gly
385                 390                 395                 400 
Asp Arg Tyr Arg Leu Leu Val Asn Cys Ile Asp Thr Val Lys Thr Pro
                405                 410                 415     
His Ser Leu Pro Lys Leu Pro Val Ala Asn Ala Leu Trp Lys Ala Gln
            420                 425                 430         
Pro Asp Leu Pro Thr Ala Ser Glu Ala Trp Ile Leu Ala Gly Gly Ala
        435                 440                 445             
His His Thr Val Phe Ser His Ala Leu Asn Leu Asn Asp Met Arg Gln
    450                 455                 460                 
Phe Ala Glu Met His Asp Ile Glu Ile Thr Val Ile Asp Asn Asp Thr
465                 470                 475                 480 
Arg Leu Pro Ala Phe Lys Asp Ala Leu Arg Trp Asn Glu Val Tyr Tyr
                485                 490                 495     
Gly Phe Arg Arg
            500 


<210> 195
<211> 1500
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in S. cerevisiae

<220> 
<221> CDS            
<222> (1)...(1500)

<400> 195
atg act att ttt gat aat tat gaa gtt tgg ttt gta att ggt tca caa   48
Met Thr Ile Phe Asp Asn Tyr Glu Val Trp Phe Val Ile Gly Ser Gln
 1               5                   10                  15
 
cat ttg tat ggt cca gaa act cta aga caa gtt act caa cat gct gaa   96
His Leu Tyr Gly Pro Glu Thr Leu Arg Gln Val Thr Gln His Ala Glu
             20                  25                  30
 
cac gta gtt aat gct tta aat act gaa gct aaa ttg cca tgt aaa tta   144
His Val Val Asn Ala Leu Asn Thr Glu Ala Lys Leu Pro Cys Lys Leu
         35                  40                  45
 
gtt tta aaa cca ttg ggt act act cca gat gaa att act gct att tgt   192
Val Leu Lys Pro Leu Gly Thr Thr Pro Asp Glu Ile Thr Ala Ile Cys
     50                  55                  60
 
aga gat gct aat tat gat gat cca tgt gct ggt tta gtt gtt tgg ttg   240
Arg Asp Ala Asn Tyr Asp Asp Pro Cys Ala Gly Leu Val Val Trp Leu
 65                  70                  75                  80
 
cat act ttt tca cca gct aaa atg tgg att aat gga ttg act atg tta   288
His Thr Phe Ser Pro Ala Lys Met Trp Ile Asn Gly Leu Thr Met Leu
                 85                  90                  95
 
aat aaa cca ttg ttg caa ttt cat act caa ttt aat gct gct ttg cca   336
Asn Lys Pro Leu Leu Gln Phe His Thr Gln Phe Asn Ala Ala Leu Pro
            100                 105                 110
 
tgg gat tct att gat atg gat ttt atg aat tta aat caa act gct cat   384
Trp Asp Ser Ile Asp Met Asp Phe Met Asn Leu Asn Gln Thr Ala His
        115                 120                 125
 
ggt ggt aga gag ttc ggt ttt att gga gct aga atg aga caa caa cac   432
Gly Gly Arg Glu Phe Gly Phe Ile Gly Ala Arg Met Arg Gln Gln His
    130                 135                 140
 
gct gta gtt act ggt cat tgg caa gat aaa caa gct cat gaa aga att   480
Ala Val Val Thr Gly His Trp Gln Asp Lys Gln Ala His Glu Arg Ile
145                 150                 155                 160
 
ggt tca tgg atg agg caa gca gtt tca aaa caa gat act aga cat tta   528
Gly Ser Trp Met Arg Gln Ala Val Ser Lys Gln Asp Thr Arg His Leu
                165                 170                 175
 
aag gtt tgt aga ttt gga gat aat atg aga gaa gta gct gtt act gac   576
Lys Val Cys Arg Phe Gly Asp Asn Met Arg Glu Val Ala Val Thr Asp
            180                 185                 190
 
ggt gat aaa gta gcc gct caa ata aaa ttc ggt ttt tct gtt aat act   624
Gly Asp Lys Val Ala Ala Gln Ile Lys Phe Gly Phe Ser Val Asn Thr
        195                 200                 205
 
tgg gct gtt ggt gat ttg gtt caa gtt gtt aat tct att tca gat ggt   672
Trp Ala Val Gly Asp Leu Val Gln Val Val Asn Ser Ile Ser Asp Gly
    210                 215                 220
 
gat gtt aat gct ttg gtt gat gaa tat gaa tct tgt tat act atg act   720
Asp Val Asn Ala Leu Val Asp Glu Tyr Glu Ser Cys Tyr Thr Met Thr
225                 230                 235                 240
 
cca gca act caa att cat ggt gag aaa aga caa aat gtt ttg gaa gct   768
Pro Ala Thr Gln Ile His Gly Glu Lys Arg Gln Asn Val Leu Glu Ala
                245                 250                 255
 
gct aga att gaa ttg gga atg aaa aga ttt tta gag caa ggt ggt ttt   816
Ala Arg Ile Glu Leu Gly Met Lys Arg Phe Leu Glu Gln Gly Gly Phe
            260                 265                 270
 
cat gct ttt act act act ttt gaa gat ttg cat ggt tta aaa caa ttg   864
His Ala Phe Thr Thr Thr Phe Glu Asp Leu His Gly Leu Lys Gln Leu
        275                 280                 285
 
cca ggt tta gct gtt caa aga tta atg caa caa ggt tat ggt ttc gct   912
Pro Gly Leu Ala Val Gln Arg Leu Met Gln Gln Gly Tyr Gly Phe Ala
    290                 295                 300
 
ggt gag ggt gat tgg aaa act gct gct ttg ttg aga att atg aaa gta   960
Gly Glu Gly Asp Trp Lys Thr Ala Ala Leu Leu Arg Ile Met Lys Val
305                 310                 315                 320
 
atg tca act ggt ttg caa ggt ggt act tct ttt atg gaa gat tat act   1008
Met Ser Thr Gly Leu Gln Gly Gly Thr Ser Phe Met Glu Asp Tyr Thr
                325                 330                 335
 
tat cat ttt gaa aaa ggt aat gat ttg gtt ttg ggt tct cac atg ttg   1056
Tyr His Phe Glu Lys Gly Asn Asp Leu Val Leu Gly Ser His Met Leu
            340                 345                 350
 
gaa gtt tgt cca tct att gct gtt gaa gaa aaa cca att ttg gat gtt   1104
Glu Val Cys Pro Ser Ile Ala Val Glu Glu Lys Pro Ile Leu Asp Val
        355                 360                 365
 
caa cat ttg gga att ggt ggt aaa gat gat cca gct aga ttg att ttt   1152
Gln His Leu Gly Ile Gly Gly Lys Asp Asp Pro Ala Arg Leu Ile Phe
    370                 375                 380
 
aat act caa act ggt cca gct att gtt gct tct ttg att gat ttg ggt   1200
Asn Thr Gln Thr Gly Pro Ala Ile Val Ala Ser Leu Ile Asp Leu Gly
385                 390                 395                 400
 
gat aga tat aga ttg ttg gtt aat tgt att gat act gtt aaa act cca   1248
Asp Arg Tyr Arg Leu Leu Val Asn Cys Ile Asp Thr Val Lys Thr Pro
                405                 410                 415
 
cat tct ttg cca aaa ttg cca gtt gct aat gca ttg tgg aaa gct caa   1296
His Ser Leu Pro Lys Leu Pro Val Ala Asn Ala Leu Trp Lys Ala Gln
            420                 425                 430
 
cca gat ttg cca act gct tct gag gct tgg att ttg gct ggt ggt gct   1344
Pro Asp Leu Pro Thr Ala Ser Glu Ala Trp Ile Leu Ala Gly Gly Ala
        435                 440                 445
 
cat cac act gtt ttt agt cat gct tta aat tta aat gat atg aga caa   1392
His His Thr Val Phe Ser His Ala Leu Asn Leu Asn Asp Met Arg Gln
    450                 455                 460
 
ttt gct gaa atg cat gac att gaa att act gta att gat aat gat act   1440
Phe Ala Glu Met His Asp Ile Glu Ile Thr Val Ile Asp Asn Asp Thr
465                 470                 475                 480
 
agg ttg cca gct ttt aaa gat gct ttg aga tgg aat gaa gtt tat tat   1488
Arg Leu Pro Ala Phe Lys Asp Ala Leu Arg Trp Asn Glu Val Tyr Tyr
                485                 490                 495
 
ggt ttt agg aga                                                   1500
Gly Phe Arg Arg
            500
 

<210> 196
<211> 500
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in S. cerevisiae

<400> 196
Met Thr Ile Phe Asp Asn Tyr Glu Val Trp Phe Val Ile Gly Ser Gln
 1               5                  10                  15      
His Leu Tyr Gly Pro Glu Thr Leu Arg Gln Val Thr Gln His Ala Glu
            20                  25                  30          
His Val Val Asn Ala Leu Asn Thr Glu Ala Lys Leu Pro Cys Lys Leu
        35                  40                  45              
Val Leu Lys Pro Leu Gly Thr Thr Pro Asp Glu Ile Thr Ala Ile Cys
    50                  55                  60                  
Arg Asp Ala Asn Tyr Asp Asp Pro Cys Ala Gly Leu Val Val Trp Leu
65                  70                  75                  80  
His Thr Phe Ser Pro Ala Lys Met Trp Ile Asn Gly Leu Thr Met Leu
                85                  90                  95      
Asn Lys Pro Leu Leu Gln Phe His Thr Gln Phe Asn Ala Ala Leu Pro
            100                 105                 110         
Trp Asp Ser Ile Asp Met Asp Phe Met Asn Leu Asn Gln Thr Ala His
        115                 120                 125             
Gly Gly Arg Glu Phe Gly Phe Ile Gly Ala Arg Met Arg Gln Gln His
    130                 135                 140                 
Ala Val Val Thr Gly His Trp Gln Asp Lys Gln Ala His Glu Arg Ile
145                 150                 155                 160 
Gly Ser Trp Met Arg Gln Ala Val Ser Lys Gln Asp Thr Arg His Leu
                165                 170                 175     
Lys Val Cys Arg Phe Gly Asp Asn Met Arg Glu Val Ala Val Thr Asp
            180                 185                 190         
Gly Asp Lys Val Ala Ala Gln Ile Lys Phe Gly Phe Ser Val Asn Thr
        195                 200                 205             
Trp Ala Val Gly Asp Leu Val Gln Val Val Asn Ser Ile Ser Asp Gly
    210                 215                 220                 
Asp Val Asn Ala Leu Val Asp Glu Tyr Glu Ser Cys Tyr Thr Met Thr
225                 230                 235                 240 
Pro Ala Thr Gln Ile His Gly Glu Lys Arg Gln Asn Val Leu Glu Ala
                245                 250                 255     
Ala Arg Ile Glu Leu Gly Met Lys Arg Phe Leu Glu Gln Gly Gly Phe
            260                 265                 270         
His Ala Phe Thr Thr Thr Phe Glu Asp Leu His Gly Leu Lys Gln Leu
        275                 280                 285             
Pro Gly Leu Ala Val Gln Arg Leu Met Gln Gln Gly Tyr Gly Phe Ala
    290                 295                 300                 
Gly Glu Gly Asp Trp Lys Thr Ala Ala Leu Leu Arg Ile Met Lys Val
305                 310                 315                 320 
Met Ser Thr Gly Leu Gln Gly Gly Thr Ser Phe Met Glu Asp Tyr Thr
                325                 330                 335     
Tyr His Phe Glu Lys Gly Asn Asp Leu Val Leu Gly Ser His Met Leu
            340                 345                 350         
Glu Val Cys Pro Ser Ile Ala Val Glu Glu Lys Pro Ile Leu Asp Val
        355                 360                 365             
Gln His Leu Gly Ile Gly Gly Lys Asp Asp Pro Ala Arg Leu Ile Phe
    370                 375                 380                 
Asn Thr Gln Thr Gly Pro Ala Ile Val Ala Ser Leu Ile Asp Leu Gly
385                 390                 395                 400 
Asp Arg Tyr Arg Leu Leu Val Asn Cys Ile Asp Thr Val Lys Thr Pro
                405                 410                 415     
His Ser Leu Pro Lys Leu Pro Val Ala Asn Ala Leu Trp Lys Ala Gln
            420                 425                 430         
Pro Asp Leu Pro Thr Ala Ser Glu Ala Trp Ile Leu Ala Gly Gly Ala
        435                 440                 445             
His His Thr Val Phe Ser His Ala Leu Asn Leu Asn Asp Met Arg Gln
    450                 455                 460                 
Phe Ala Glu Met His Asp Ile Glu Ile Thr Val Ile Asp Asn Asp Thr
465                 470                 475                 480 
Arg Leu Pro Ala Phe Lys Asp Ala Leu Arg Trp Asn Glu Val Tyr Tyr
                485                 490                 495     
Gly Phe Arg Arg
            500 


<210> 197
<211> 1522
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in S. cerevisiae

<220> 
<221> CDS            
<222> (12)...(1511)

<400> 197
tactcaagct t atg act att ttt gat aat tat gaa gtt tgg ttt gta att  50
             Met Thr Ile Phe Asp Asn Tyr Glu Val Trp Phe Val Ile
              1               5                   10
 
ggt tca caa cat ttg tat ggt cca gaa act cta aga caa gtt act caa   98
Gly Ser Gln His Leu Tyr Gly Pro Glu Thr Leu Arg Gln Val Thr Gln
     15                  20                  25
 
cat gct gaa cac gta gtt aat gct tta aat act gaa gct aaa ttg cca   146
His Ala Glu His Val Val Asn Ala Leu Asn Thr Glu Ala Lys Leu Pro
 30                  35                  40                  45
 
tgt aaa tta gtt tta aaa cca ttg ggt act act cca gat gaa att act   194
Cys Lys Leu Val Leu Lys Pro Leu Gly Thr Thr Pro Asp Glu Ile Thr
                 50                  55                  60
 
gct att tgt aga gat gct aat tat gat gat cca tgt gct ggt tta gtt   242
Ala Ile Cys Arg Asp Ala Asn Tyr Asp Asp Pro Cys Ala Gly Leu Val
             65                  70                  75
 
gtt tgg ttg cat act ttt tca cca gct aaa atg tgg att aat gga ttg   290
Val Trp Leu His Thr Phe Ser Pro Ala Lys Met Trp Ile Asn Gly Leu
         80                  85                  90
 
act atg tta aat aaa cca ttg ttg caa ttt cat act caa ttt aat gct   338
Thr Met Leu Asn Lys Pro Leu Leu Gln Phe His Thr Gln Phe Asn Ala
     95                 100                 105
 
gct ttg cca tgg gat tct att gat atg gat ttt atg aat tta aat caa   386
Ala Leu Pro Trp Asp Ser Ile Asp Met Asp Phe Met Asn Leu Asn Gln
110                 115                 120                 125
 
act gct cat ggt ggt aga gag ttc ggt ttt att gga gct aga atg aga   434
Thr Ala His Gly Gly Arg Glu Phe Gly Phe Ile Gly Ala Arg Met Arg
                130                 135                 140
 
caa caa cac gct gta gtt act ggt cat tgg caa gat aaa caa gct cat   482
Gln Gln His Ala Val Val Thr Gly His Trp Gln Asp Lys Gln Ala His
            145                 150                 155
 
gaa aga att ggt tca tgg atg agg caa gca gtt tca aaa caa gat act   530
Glu Arg Ile Gly Ser Trp Met Arg Gln Ala Val Ser Lys Gln Asp Thr
        160                 165                 170
 
aga cat tta aag gtt tgt aga ttt gga gat aat atg aga gaa gta gct   578
Arg His Leu Lys Val Cys Arg Phe Gly Asp Asn Met Arg Glu Val Ala
    175                 180                 185
 
gtt act gac ggt gat aaa gta gcc gct caa ata aaa ttc ggt ttt tct   626
Val Thr Asp Gly Asp Lys Val Ala Ala Gln Ile Lys Phe Gly Phe Ser
190                 195                 200                 205
 
gtt aat act tgg gct gtt ggt gat ttg gtt caa gtt gtt aat tct att   674
Val Asn Thr Trp Ala Val Gly Asp Leu Val Gln Val Val Asn Ser Ile
                210                 215                 220
 
tca gat ggt gat gtt aat gct ttg gtt gat gaa tat gaa tct tgt tat   722
Ser Asp Gly Asp Val Asn Ala Leu Val Asp Glu Tyr Glu Ser Cys Tyr
            225                 230                 235
 
act atg act cca gca act caa att cat ggt gag aaa aga caa aat gtt   770
Thr Met Thr Pro Ala Thr Gln Ile His Gly Glu Lys Arg Gln Asn Val
        240                 245                 250
 
ttg gaa gct gct aga att gaa ttg gga atg aaa aga ttt tta gag caa   818
Leu Glu Ala Ala Arg Ile Glu Leu Gly Met Lys Arg Phe Leu Glu Gln
    255                 260                 265
 
ggt ggt ttt cat gct ttt act act act ttt gaa gat ttg cat ggt tta   866
Gly Gly Phe His Ala Phe Thr Thr Thr Phe Glu Asp Leu His Gly Leu
270                 275                 280                 285
 
aaa caa ttg cca ggt tta gct gtt caa aga tta atg caa caa ggt tat   914
Lys Gln Leu Pro Gly Leu Ala Val Gln Arg Leu Met Gln Gln Gly Tyr
                290                 295                 300
 
ggt ttc gct ggt gag ggt gat tgg aaa act gct gct ttg ttg aga att   962
Gly Phe Ala Gly Glu Gly Asp Trp Lys Thr Ala Ala Leu Leu Arg Ile
            305                 310                 315
 
atg aaa gta atg tca act ggt ttg caa ggt ggt act tct ttt atg gaa   1010
Met Lys Val Met Ser Thr Gly Leu Gln Gly Gly Thr Ser Phe Met Glu
        320                 325                 330
 
gat tat act tat cat ttt gaa aaa ggt aat gat ttg gtt ttg ggt tct   1058
Asp Tyr Thr Tyr His Phe Glu Lys Gly Asn Asp Leu Val Leu Gly Ser
    335                 340                 345
 
cac atg ttg gaa gtt tgt cca tct att gct gtt gaa gaa aaa cca att   1106
His Met Leu Glu Val Cys Pro Ser Ile Ala Val Glu Glu Lys Pro Ile
350                 355                 360                 365
 
ttg gat gtt caa cat ttg gga att ggt ggt aaa gat gat cca gct aga   1154
Leu Asp Val Gln His Leu Gly Ile Gly Gly Lys Asp Asp Pro Ala Arg
                370                 375                 380
 
ttg att ttt aat act caa act ggt cca gct att gtt gct tct ttg att   1202
Leu Ile Phe Asn Thr Gln Thr Gly Pro Ala Ile Val Ala Ser Leu Ile
            385                 390                 395
 
gat ttg ggt gat aga tat aga ttg ttg gtt aat tgt att gat act gtt   1250
Asp Leu Gly Asp Arg Tyr Arg Leu Leu Val Asn Cys Ile Asp Thr Val
        400                 405                 410
 
aaa act cca cat tct ttg cca aaa ttg cca gtt gct aat gca ttg tgg   1298
Lys Thr Pro His Ser Leu Pro Lys Leu Pro Val Ala Asn Ala Leu Trp
    415                 420                 425
 
aaa gct caa cca gat ttg cca act gct tct gag gct tgg att ttg gct   1346
Lys Ala Gln Pro Asp Leu Pro Thr Ala Ser Glu Ala Trp Ile Leu Ala
430                 435                 440                 445
 
ggt ggt gct cat cac act gtt ttt agt cat gct tta aat tta aat gat   1394
Gly Gly Ala His His Thr Val Phe Ser His Ala Leu Asn Leu Asn Asp
                450                 455                 460
 
atg aga caa ttt gct gaa atg cat gac att gaa att act gta att gat   1442
Met Arg Gln Phe Ala Glu Met His Asp Ile Glu Ile Thr Val Ile Asp
            465                 470                 475
 
aat gat act agg ttg cca gct ttt aaa gat gct ttg aga tgg aat gaa   1490
Asn Asp Thr Arg Leu Pro Ala Phe Lys Asp Ala Leu Arg Trp Asn Glu
        480                 485                 490
 
gtt tat tat ggt ttt agg aga gaattccgat g                          1522
Val Tyr Tyr Gly Phe Arg Arg
    495                 500
 

<210> 198
<211> 500
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in S. cerevisiae

<400> 198
Met Thr Ile Phe Asp Asn Tyr Glu Val Trp Phe Val Ile Gly Ser Gln
 1               5                  10                  15      
His Leu Tyr Gly Pro Glu Thr Leu Arg Gln Val Thr Gln His Ala Glu
            20                  25                  30          
His Val Val Asn Ala Leu Asn Thr Glu Ala Lys Leu Pro Cys Lys Leu
        35                  40                  45              
Val Leu Lys Pro Leu Gly Thr Thr Pro Asp Glu Ile Thr Ala Ile Cys
    50                  55                  60                  
Arg Asp Ala Asn Tyr Asp Asp Pro Cys Ala Gly Leu Val Val Trp Leu
65                  70                  75                  80  
His Thr Phe Ser Pro Ala Lys Met Trp Ile Asn Gly Leu Thr Met Leu
                85                  90                  95      
Asn Lys Pro Leu Leu Gln Phe His Thr Gln Phe Asn Ala Ala Leu Pro
            100                 105                 110         
Trp Asp Ser Ile Asp Met Asp Phe Met Asn Leu Asn Gln Thr Ala His
        115                 120                 125             
Gly Gly Arg Glu Phe Gly Phe Ile Gly Ala Arg Met Arg Gln Gln His
    130                 135                 140                 
Ala Val Val Thr Gly His Trp Gln Asp Lys Gln Ala His Glu Arg Ile
145                 150                 155                 160 
Gly Ser Trp Met Arg Gln Ala Val Ser Lys Gln Asp Thr Arg His Leu
                165                 170                 175     
Lys Val Cys Arg Phe Gly Asp Asn Met Arg Glu Val Ala Val Thr Asp
            180                 185                 190         
Gly Asp Lys Val Ala Ala Gln Ile Lys Phe Gly Phe Ser Val Asn Thr
        195                 200                 205             
Trp Ala Val Gly Asp Leu Val Gln Val Val Asn Ser Ile Ser Asp Gly
    210                 215                 220                 
Asp Val Asn Ala Leu Val Asp Glu Tyr Glu Ser Cys Tyr Thr Met Thr
225                 230                 235                 240 
Pro Ala Thr Gln Ile His Gly Glu Lys Arg Gln Asn Val Leu Glu Ala
                245                 250                 255     
Ala Arg Ile Glu Leu Gly Met Lys Arg Phe Leu Glu Gln Gly Gly Phe
            260                 265                 270         
His Ala Phe Thr Thr Thr Phe Glu Asp Leu His Gly Leu Lys Gln Leu
        275                 280                 285             
Pro Gly Leu Ala Val Gln Arg Leu Met Gln Gln Gly Tyr Gly Phe Ala
    290                 295                 300                 
Gly Glu Gly Asp Trp Lys Thr Ala Ala Leu Leu Arg Ile Met Lys Val
305                 310                 315                 320 
Met Ser Thr Gly Leu Gln Gly Gly Thr Ser Phe Met Glu Asp Tyr Thr
                325                 330                 335     
Tyr His Phe Glu Lys Gly Asn Asp Leu Val Leu Gly Ser His Met Leu
            340                 345                 350         
Glu Val Cys Pro Ser Ile Ala Val Glu Glu Lys Pro Ile Leu Asp Val
        355                 360                 365             
Gln His Leu Gly Ile Gly Gly Lys Asp Asp Pro Ala Arg Leu Ile Phe
    370                 375                 380                 
Asn Thr Gln Thr Gly Pro Ala Ile Val Ala Ser Leu Ile Asp Leu Gly
385                 390                 395                 400 
Asp Arg Tyr Arg Leu Leu Val Asn Cys Ile Asp Thr Val Lys Thr Pro
                405                 410                 415     
His Ser Leu Pro Lys Leu Pro Val Ala Asn Ala Leu Trp Lys Ala Gln
            420                 425                 430         
Pro Asp Leu Pro Thr Ala Ser Glu Ala Trp Ile Leu Ala Gly Gly Ala
        435                 440                 445             
His His Thr Val Phe Ser His Ala Leu Asn Leu Asn Asp Met Arg Gln
    450                 455                 460                 
Phe Ala Glu Met His Asp Ile Glu Ile Thr Val Ile Asp Asn Asp Thr
465                 470                 475                 480 
Arg Leu Pro Ala Phe Lys Asp Ala Leu Arg Trp Asn Glu Val Tyr Tyr
                485                 490                 495     
Gly Phe Arg Arg
            500 


<210> 199
<211> 1528
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in S. cerevisiae

<220> 
<221> CDS            
<222> (15)...(1514)

<400> 199
gaatactcca tatg atg act att ttt gat aat tat gaa gtt tgg ttt gta   50
                Met Thr Ile Phe Asp Asn Tyr Glu Val Trp Phe Val
                 1               5                   10
 
att ggt tca caa cat ttg tat ggt cca gaa act cta aga caa gtt act   98
Ile Gly Ser Gln His Leu Tyr Gly Pro Glu Thr Leu Arg Gln Val Thr
         15                  20                  25
 
caa cat gct gaa cac gta gtt aat gct tta aat act gaa gct aaa ttg   146
Gln His Ala Glu His Val Val Asn Ala Leu Asn Thr Glu Ala Lys Leu
     30                  35                  40
 
cca tgt aaa tta gtt tta aaa cca ttg ggt act act cca gat gaa att   194
Pro Cys Lys Leu Val Leu Lys Pro Leu Gly Thr Thr Pro Asp Glu Ile
 45                  50                  55                  60
 
act gct att tgt aga gat gct aat tat gat gat cca tgt gct ggt tta   242
Thr Ala Ile Cys Arg Asp Ala Asn Tyr Asp Asp Pro Cys Ala Gly Leu
                 65                  70                  75
 
gtt gtt tgg ttg cat act ttt tca cca gct aaa atg tgg att aat gga   290
Val Val Trp Leu His Thr Phe Ser Pro Ala Lys Met Trp Ile Asn Gly
             80                  85                  90
 
ttg act atg tta aat aaa cca ttg ttg caa ttt cat act caa ttt aat   338
Leu Thr Met Leu Asn Lys Pro Leu Leu Gln Phe His Thr Gln Phe Asn
         95                 100                 105
 
gct gct ttg cca tgg gat tct att gat atg gat ttt atg aat tta aat   386
Ala Ala Leu Pro Trp Asp Ser Ile Asp Met Asp Phe Met Asn Leu Asn
    110                 115                 120
 
caa act gct cat ggt ggt aga gag ttc ggt ttt att gga gct aga atg   434
Gln Thr Ala His Gly Gly Arg Glu Phe Gly Phe Ile Gly Ala Arg Met
125                 130                 135                 140
 
aga caa caa cac gct gta gtt act ggt cat tgg caa gat aaa caa gct   482
Arg Gln Gln His Ala Val Val Thr Gly His Trp Gln Asp Lys Gln Ala
                145                 150                 155
 
cat gaa aga att ggt tca tgg atg agg caa gca gtt tca aaa caa gat   530
His Glu Arg Ile Gly Ser Trp Met Arg Gln Ala Val Ser Lys Gln Asp
            160                 165                 170
 
act aga cat tta aag gtt tgt aga ttt gga gat aat atg aga gaa gta   578
Thr Arg His Leu Lys Val Cys Arg Phe Gly Asp Asn Met Arg Glu Val
        175                 180                 185
 
gct gtt act gac ggt gat aaa gta gcc gct caa ata aaa ttc ggt ttt   626
Ala Val Thr Asp Gly Asp Lys Val Ala Ala Gln Ile Lys Phe Gly Phe
    190                 195                 200
 
tct gtt aat act tgg gct gtt ggt gat ttg gtt caa gtt gtt aat tct   674
Ser Val Asn Thr Trp Ala Val Gly Asp Leu Val Gln Val Val Asn Ser
205                 210                 215                 220
 
att tca gat ggt gat gtt aat gct ttg gtt gat gaa tat gaa tct tgt   722
Ile Ser Asp Gly Asp Val Asn Ala Leu Val Asp Glu Tyr Glu Ser Cys
                225                 230                 235
 
tat act atg act cca gca act caa att cat ggt gag aaa aga caa aat   770
Tyr Thr Met Thr Pro Ala Thr Gln Ile His Gly Glu Lys Arg Gln Asn
            240                 245                 250
 
gtt ttg gaa gct gct aga att gaa ttg gga atg aaa aga ttt tta gag   818
Val Leu Glu Ala Ala Arg Ile Glu Leu Gly Met Lys Arg Phe Leu Glu
        255                 260                 265
 
caa ggt ggt ttt cat gct ttt act act act ttt gaa gat ttg cat ggt   866
Gln Gly Gly Phe His Ala Phe Thr Thr Thr Phe Glu Asp Leu His Gly
    270                 275                 280
 
tta aaa caa ttg cca ggt tta gct gtt caa aga tta atg caa caa ggt   914
Leu Lys Gln Leu Pro Gly Leu Ala Val Gln Arg Leu Met Gln Gln Gly
285                 290                 295                 300
 
tat ggt ttc gct ggt gag ggt gat tgg aaa act gct gct ttg ttg aga   962
Tyr Gly Phe Ala Gly Glu Gly Asp Trp Lys Thr Ala Ala Leu Leu Arg
                305                 310                 315
 
att atg aaa gta atg tca act ggt ttg caa ggt ggt act tct ttt atg   1010
Ile Met Lys Val Met Ser Thr Gly Leu Gln Gly Gly Thr Ser Phe Met
            320                 325                 330
 
gaa gat tat act tat cat ttt gaa aaa ggt aat gat ttg gtt ttg ggt   1058
Glu Asp Tyr Thr Tyr His Phe Glu Lys Gly Asn Asp Leu Val Leu Gly
        335                 340                 345
 
tct cac atg ttg gaa gtt tgt cca tct att gct gtt gaa gaa aaa cca   1106
Ser His Met Leu Glu Val Cys Pro Ser Ile Ala Val Glu Glu Lys Pro
    350                 355                 360
 
att ttg gat gtt caa cat ttg gga att ggt ggt aaa gat gat cca gct   1154
Ile Leu Asp Val Gln His Leu Gly Ile Gly Gly Lys Asp Asp Pro Ala
365                 370                 375                 380
 
aga ttg att ttt aat act caa act ggt cca gct att gtt gct tct ttg   1202
Arg Leu Ile Phe Asn Thr Gln Thr Gly Pro Ala Ile Val Ala Ser Leu
                385                 390                 395
 
att gat ttg ggt gat aga tat aga ttg ttg gtt aat tgt att gat act   1250
Ile Asp Leu Gly Asp Arg Tyr Arg Leu Leu Val Asn Cys Ile Asp Thr
            400                 405                 410
 
gtt aaa act cca cat tct ttg cca aaa ttg cca gtt gct aat gca ttg   1298
Val Lys Thr Pro His Ser Leu Pro Lys Leu Pro Val Ala Asn Ala Leu
        415                 420                 425
 
tgg aaa gct caa cca gat ttg cca act gct tct gag gct tgg att ttg   1346
Trp Lys Ala Gln Pro Asp Leu Pro Thr Ala Ser Glu Ala Trp Ile Leu
    430                 435                 440
 
gct ggt ggt gct cat cac act gtt ttt agt cat gct tta aat tta aat   1394
Ala Gly Gly Ala His His Thr Val Phe Ser His Ala Leu Asn Leu Asn
445                 450                 455                 460
 
gat atg aga caa ttt gct gaa atg cat gac att gaa att act gta att   1442
Asp Met Arg Gln Phe Ala Glu Met His Asp Ile Glu Ile Thr Val Ile
                465                 470                 475
 
gat aat gat act agg ttg cca gct ttt aaa gat gct ttg aga tgg aat   1490
Asp Asn Asp Thr Arg Leu Pro Ala Phe Lys Asp Ala Leu Arg Trp Asn
            480                 485                 490
 
gaa gtt tat tat ggt ttt agg aga actagtcgat gcct                   1528
Glu Val Tyr Tyr Gly Phe Arg Arg
        495                 500
 

<210> 200
<211> 500
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in S. cerevisiae

<400> 200
Met Thr Ile Phe Asp Asn Tyr Glu Val Trp Phe Val Ile Gly Ser Gln
 1               5                  10                  15      
His Leu Tyr Gly Pro Glu Thr Leu Arg Gln Val Thr Gln His Ala Glu
            20                  25                  30          
His Val Val Asn Ala Leu Asn Thr Glu Ala Lys Leu Pro Cys Lys Leu
        35                  40                  45              
Val Leu Lys Pro Leu Gly Thr Thr Pro Asp Glu Ile Thr Ala Ile Cys
    50                  55                  60                  
Arg Asp Ala Asn Tyr Asp Asp Pro Cys Ala Gly Leu Val Val Trp Leu
65                  70                  75                  80  
His Thr Phe Ser Pro Ala Lys Met Trp Ile Asn Gly Leu Thr Met Leu
                85                  90                  95      
Asn Lys Pro Leu Leu Gln Phe His Thr Gln Phe Asn Ala Ala Leu Pro
            100                 105                 110         
Trp Asp Ser Ile Asp Met Asp Phe Met Asn Leu Asn Gln Thr Ala His
        115                 120                 125             
Gly Gly Arg Glu Phe Gly Phe Ile Gly Ala Arg Met Arg Gln Gln His
    130                 135                 140                 
Ala Val Val Thr Gly His Trp Gln Asp Lys Gln Ala His Glu Arg Ile
145                 150                 155                 160 
Gly Ser Trp Met Arg Gln Ala Val Ser Lys Gln Asp Thr Arg His Leu
                165                 170                 175     
Lys Val Cys Arg Phe Gly Asp Asn Met Arg Glu Val Ala Val Thr Asp
            180                 185                 190         
Gly Asp Lys Val Ala Ala Gln Ile Lys Phe Gly Phe Ser Val Asn Thr
        195                 200                 205             
Trp Ala Val Gly Asp Leu Val Gln Val Val Asn Ser Ile Ser Asp Gly
    210                 215                 220                 
Asp Val Asn Ala Leu Val Asp Glu Tyr Glu Ser Cys Tyr Thr Met Thr
225                 230                 235                 240 
Pro Ala Thr Gln Ile His Gly Glu Lys Arg Gln Asn Val Leu Glu Ala
                245                 250                 255     
Ala Arg Ile Glu Leu Gly Met Lys Arg Phe Leu Glu Gln Gly Gly Phe
            260                 265                 270         
His Ala Phe Thr Thr Thr Phe Glu Asp Leu His Gly Leu Lys Gln Leu
        275                 280                 285             
Pro Gly Leu Ala Val Gln Arg Leu Met Gln Gln Gly Tyr Gly Phe Ala
    290                 295                 300                 
Gly Glu Gly Asp Trp Lys Thr Ala Ala Leu Leu Arg Ile Met Lys Val
305                 310                 315                 320 
Met Ser Thr Gly Leu Gln Gly Gly Thr Ser Phe Met Glu Asp Tyr Thr
                325                 330                 335     
Tyr His Phe Glu Lys Gly Asn Asp Leu Val Leu Gly Ser His Met Leu
            340                 345                 350         
Glu Val Cys Pro Ser Ile Ala Val Glu Glu Lys Pro Ile Leu Asp Val
        355                 360                 365             
Gln His Leu Gly Ile Gly Gly Lys Asp Asp Pro Ala Arg Leu Ile Phe
    370                 375                 380                 
Asn Thr Gln Thr Gly Pro Ala Ile Val Ala Ser Leu Ile Asp Leu Gly
385                 390                 395                 400 
Asp Arg Tyr Arg Leu Leu Val Asn Cys Ile Asp Thr Val Lys Thr Pro
                405                 410                 415     
His Ser Leu Pro Lys Leu Pro Val Ala Asn Ala Leu Trp Lys Ala Gln
            420                 425                 430         
Pro Asp Leu Pro Thr Ala Ser Glu Ala Trp Ile Leu Ala Gly Gly Ala
        435                 440                 445             
His His Thr Val Phe Ser His Ala Leu Asn Leu Asn Asp Met Arg Gln
    450                 455                 460                 
Phe Ala Glu Met His Asp Ile Glu Ile Thr Val Ile Asp Asn Asp Thr
465                 470                 475                 480 
Arg Leu Pro Ala Phe Lys Asp Ala Leu Arg Trp Asn Glu Val Tyr Tyr
                485                 490                 495     
Gly Phe Arg Arg
            500 


<210> 201
<211> 1500
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in E. coli

<220> 
<221> CDS            
<222> (1)...(1500)

<400> 201
atg act att ttt gat aat tat gaa gtt tgg ttt gta att ggt tca caa   48
Met Thr Ile Phe Asp Asn Tyr Glu Val Trp Phe Val Ile Gly Ser Gln
 1               5                   10                  15
 
cat ttg tat ggt cca gaa act cta aga caa gtt act caa cat gct gaa   96
His Leu Tyr Gly Pro Glu Thr Leu Arg Gln Val Thr Gln His Ala Glu
             20                  25                  30
 
cac gta gtt aat gct tta aat act gaa gct aaa ttg cca tgt aaa tta   144
His Val Val Asn Ala Leu Asn Thr Glu Ala Lys Leu Pro Cys Lys Leu
         35                  40                  45
 
gtt tta aaa cca ttg ggt act act cca gat gaa att act gct att tgt   192
Val Leu Lys Pro Leu Gly Thr Thr Pro Asp Glu Ile Thr Ala Ile Cys
     50                  55                  60
 
aga gat gct aat tat gat gat cca tgt gct ggt tta gtt gtt tgg ttg   240
Arg Asp Ala Asn Tyr Asp Asp Pro Cys Ala Gly Leu Val Val Trp Leu
 65                  70                  75                  80
 
cat act ttt tca cca gct aaa atg tgg att aat gga ttg act atg tta   288
His Thr Phe Ser Pro Ala Lys Met Trp Ile Asn Gly Leu Thr Met Leu
                 85                  90                  95
 
aat aaa cca ttg ttg caa ttt cat act caa ttt aat gct gct ttg cca   336
Asn Lys Pro Leu Leu Gln Phe His Thr Gln Phe Asn Ala Ala Leu Pro
            100                 105                 110
 
tgg gat tct att gat atg gat ttt atg aat tta aat caa act gct cat   384
Trp Asp Ser Ile Asp Met Asp Phe Met Asn Leu Asn Gln Thr Ala His
        115                 120                 125
 
ggt ggt aga gag ttc ggt ttt att gga gct aga atg aga caa caa cac   432
Gly Gly Arg Glu Phe Gly Phe Ile Gly Ala Arg Met Arg Gln Gln His
    130                 135                 140
 
gct gta gtt act ggt cat tgg caa gat aaa caa gct cat gaa aga att   480
Ala Val Val Thr Gly His Trp Gln Asp Lys Gln Ala His Glu Arg Ile
145                 150                 155                 160
 
ggt tca tgg atg agg caa gca gtt tca aaa caa gat act aga cat tta   528
Gly Ser Trp Met Arg Gln Ala Val Ser Lys Gln Asp Thr Arg His Leu
                165                 170                 175
 
aag gtt tgt aga ttt gga gat aat atg aga gaa gta gct gtt act gac   576
Lys Val Cys Arg Phe Gly Asp Asn Met Arg Glu Val Ala Val Thr Asp
            180                 185                 190
 
ggt gat aaa gta gcc gct caa ata aaa ttc ggt ttt tct gtt aat act   624
Gly Asp Lys Val Ala Ala Gln Ile Lys Phe Gly Phe Ser Val Asn Thr
        195                 200                 205
 
tgg gct gtt ggt gat ttg gtt caa gtt gtt aat tct att tca gat ggt   672
Trp Ala Val Gly Asp Leu Val Gln Val Val Asn Ser Ile Ser Asp Gly
    210                 215                 220
 
gat gtt aat gct ttg gtt gat gaa tat gaa tct tgt tat act atg act   720
Asp Val Asn Ala Leu Val Asp Glu Tyr Glu Ser Cys Tyr Thr Met Thr
225                 230                 235                 240
 
cca gca act caa att cat ggt gag aaa aga caa aat gtt ttg gaa gct   768
Pro Ala Thr Gln Ile His Gly Glu Lys Arg Gln Asn Val Leu Glu Ala
                245                 250                 255
 
gct aga att gaa ttg gga atg aaa aga ttt tta gag caa ggt ggt ttt   816
Ala Arg Ile Glu Leu Gly Met Lys Arg Phe Leu Glu Gln Gly Gly Phe
            260                 265                 270
 
cat gct ttt act act act ttt gaa gat ttg cat ggt tta aaa caa ttg   864
His Ala Phe Thr Thr Thr Phe Glu Asp Leu His Gly Leu Lys Gln Leu
        275                 280                 285
 
cca ggt tta gct gtt caa aga tta atg caa caa ggt tat ggt ttc gct   912
Pro Gly Leu Ala Val Gln Arg Leu Met Gln Gln Gly Tyr Gly Phe Ala
    290                 295                 300
 
ggt gag ggt gat tgg aaa act gct gct ttg ttg aga att atg aaa gta   960
Gly Glu Gly Asp Trp Lys Thr Ala Ala Leu Leu Arg Ile Met Lys Val
305                 310                 315                 320
 
atg tca act ggt ttg caa ggt ggt act tct ttt atg gaa gat tat act   1008
Met Ser Thr Gly Leu Gln Gly Gly Thr Ser Phe Met Glu Asp Tyr Thr
                325                 330                 335
 
tat cat ttt gaa aaa ggt aat gat ttg gtt ttg ggt tct cac atg ttg   1056
Tyr His Phe Glu Lys Gly Asn Asp Leu Val Leu Gly Ser His Met Leu
            340                 345                 350
 
gaa gtt tgt cca tct att gct gtt gaa gaa aaa cca att ttg gat gtt   1104
Glu Val Cys Pro Ser Ile Ala Val Glu Glu Lys Pro Ile Leu Asp Val
        355                 360                 365
 
caa cat ttg gga att ggt ggt aaa gat gat cca gct aga ttg att ttt   1152
Gln His Leu Gly Ile Gly Gly Lys Asp Asp Pro Ala Arg Leu Ile Phe
    370                 375                 380
 
aat act caa act ggt cca gct att gtt gct tct ttg att gat ttg ggt   1200
Asn Thr Gln Thr Gly Pro Ala Ile Val Ala Ser Leu Ile Asp Leu Gly
385                 390                 395                 400
 
gat aga tat aga ttg ttg gtt aat tgt att gat act gtt aaa act cca   1248
Asp Arg Tyr Arg Leu Leu Val Asn Cys Ile Asp Thr Val Lys Thr Pro
                405                 410                 415
 
cat tct ttg cca aaa ttg cca gtt gct aat gca ttg tgg aaa gct caa   1296
His Ser Leu Pro Lys Leu Pro Val Ala Asn Ala Leu Trp Lys Ala Gln
            420                 425                 430
 
cca gat ttg cca act gct tct gag gct tgg att ttg gct ggt ggt gct   1344
Pro Asp Leu Pro Thr Ala Ser Glu Ala Trp Ile Leu Ala Gly Gly Ala
        435                 440                 445
 
cat cac act gtt ttt agt cat gct tta aat tta aat gat atg aga caa   1392
His His Thr Val Phe Ser His Ala Leu Asn Leu Asn Asp Met Arg Gln
    450                 455                 460
 
ttt gct gaa atg cat gac att gaa att act gta att gat aat gat act   1440
Phe Ala Glu Met His Asp Ile Glu Ile Thr Val Ile Asp Asn Asp Thr
465                 470                 475                 480
 
agg ttg cca gct ttt aaa gat gct ttg aga tgg aat gaa gtt tat tat   1488
Arg Leu Pro Ala Phe Lys Asp Ala Leu Arg Trp Asn Glu Val Tyr Tyr
                485                 490                 495
 
ggt ttt agg aga                                                   1500
Gly Phe Arg Arg
            500
 

<210> 202
<211> 500
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in E. coli

<400> 202
Met Thr Ile Phe Asp Asn Tyr Glu Val Trp Phe Val Ile Gly Ser Gln
 1               5                  10                  15      
His Leu Tyr Gly Pro Glu Thr Leu Arg Gln Val Thr Gln His Ala Glu
            20                  25                  30          
His Val Val Asn Ala Leu Asn Thr Glu Ala Lys Leu Pro Cys Lys Leu
        35                  40                  45              
Val Leu Lys Pro Leu Gly Thr Thr Pro Asp Glu Ile Thr Ala Ile Cys
    50                  55                  60                  
Arg Asp Ala Asn Tyr Asp Asp Pro Cys Ala Gly Leu Val Val Trp Leu
65                  70                  75                  80  
His Thr Phe Ser Pro Ala Lys Met Trp Ile Asn Gly Leu Thr Met Leu
                85                  90                  95      
Asn Lys Pro Leu Leu Gln Phe His Thr Gln Phe Asn Ala Ala Leu Pro
            100                 105                 110         
Trp Asp Ser Ile Asp Met Asp Phe Met Asn Leu Asn Gln Thr Ala His
        115                 120                 125             
Gly Gly Arg Glu Phe Gly Phe Ile Gly Ala Arg Met Arg Gln Gln His
    130                 135                 140                 
Ala Val Val Thr Gly His Trp Gln Asp Lys Gln Ala His Glu Arg Ile
145                 150                 155                 160 
Gly Ser Trp Met Arg Gln Ala Val Ser Lys Gln Asp Thr Arg His Leu
                165                 170                 175     
Lys Val Cys Arg Phe Gly Asp Asn Met Arg Glu Val Ala Val Thr Asp
            180                 185                 190         
Gly Asp Lys Val Ala Ala Gln Ile Lys Phe Gly Phe Ser Val Asn Thr
        195                 200                 205             
Trp Ala Val Gly Asp Leu Val Gln Val Val Asn Ser Ile Ser Asp Gly
    210                 215                 220                 
Asp Val Asn Ala Leu Val Asp Glu Tyr Glu Ser Cys Tyr Thr Met Thr
225                 230                 235                 240 
Pro Ala Thr Gln Ile His Gly Glu Lys Arg Gln Asn Val Leu Glu Ala
                245                 250                 255     
Ala Arg Ile Glu Leu Gly Met Lys Arg Phe Leu Glu Gln Gly Gly Phe
            260                 265                 270         
His Ala Phe Thr Thr Thr Phe Glu Asp Leu His Gly Leu Lys Gln Leu
        275                 280                 285             
Pro Gly Leu Ala Val Gln Arg Leu Met Gln Gln Gly Tyr Gly Phe Ala
    290                 295                 300                 
Gly Glu Gly Asp Trp Lys Thr Ala Ala Leu Leu Arg Ile Met Lys Val
305                 310                 315                 320 
Met Ser Thr Gly Leu Gln Gly Gly Thr Ser Phe Met Glu Asp Tyr Thr
                325                 330                 335     
Tyr His Phe Glu Lys Gly Asn Asp Leu Val Leu Gly Ser His Met Leu
            340                 345                 350         
Glu Val Cys Pro Ser Ile Ala Val Glu Glu Lys Pro Ile Leu Asp Val
        355                 360                 365             
Gln His Leu Gly Ile Gly Gly Lys Asp Asp Pro Ala Arg Leu Ile Phe
    370                 375                 380                 
Asn Thr Gln Thr Gly Pro Ala Ile Val Ala Ser Leu Ile Asp Leu Gly
385                 390                 395                 400 
Asp Arg Tyr Arg Leu Leu Val Asn Cys Ile Asp Thr Val Lys Thr Pro
                405                 410                 415     
His Ser Leu Pro Lys Leu Pro Val Ala Asn Ala Leu Trp Lys Ala Gln
            420                 425                 430         
Pro Asp Leu Pro Thr Ala Ser Glu Ala Trp Ile Leu Ala Gly Gly Ala
        435                 440                 445             
His His Thr Val Phe Ser His Ala Leu Asn Leu Asn Asp Met Arg Gln
    450                 455                 460                 
Phe Ala Glu Met His Asp Ile Glu Ile Thr Val Ile Asp Asn Asp Thr
465                 470                 475                 480 
Arg Leu Pro Ala Phe Lys Asp Ala Leu Arg Trp Asn Glu Val Tyr Tyr
                485                 490                 495     
Gly Phe Arg Arg
            500 


<210> 203
<211> 1522
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in E. coli

<220> 
<221> CDS            
<222> (12)...(1511)

<400> 203
tactcaagct t atg act att ttt gat aat tat gaa gtt tgg ttt gta att  50
             Met Thr Ile Phe Asp Asn Tyr Glu Val Trp Phe Val Ile
              1               5                   10
 
ggt tca caa cat ttg tat ggt cca gaa act cta aga caa gtt act caa   98
Gly Ser Gln His Leu Tyr Gly Pro Glu Thr Leu Arg Gln Val Thr Gln
     15                  20                  25
 
cat gct gaa cac gta gtt aat gct tta aat act gaa gct aaa ttg cca   146
His Ala Glu His Val Val Asn Ala Leu Asn Thr Glu Ala Lys Leu Pro
 30                  35                  40                  45
 
tgt aaa tta gtt tta aaa cca ttg ggt act act cca gat gaa att act   194
Cys Lys Leu Val Leu Lys Pro Leu Gly Thr Thr Pro Asp Glu Ile Thr
                 50                  55                  60
 
gct att tgt aga gat gct aat tat gat gat cca tgt gct ggt tta gtt   242
Ala Ile Cys Arg Asp Ala Asn Tyr Asp Asp Pro Cys Ala Gly Leu Val
             65                  70                  75
 
gtt tgg ttg cat act ttt tca cca gct aaa atg tgg att aat gga ttg   290
Val Trp Leu His Thr Phe Ser Pro Ala Lys Met Trp Ile Asn Gly Leu
         80                  85                  90
 
act atg tta aat aaa cca ttg ttg caa ttt cat act caa ttt aat gct   338
Thr Met Leu Asn Lys Pro Leu Leu Gln Phe His Thr Gln Phe Asn Ala
     95                 100                 105
 
gct ttg cca tgg gat tct att gat atg gat ttt atg aat tta aat caa   386
Ala Leu Pro Trp Asp Ser Ile Asp Met Asp Phe Met Asn Leu Asn Gln
110                 115                 120                 125
 
act gct cat ggt ggt aga gag ttc ggt ttt att gga gct aga atg aga   434
Thr Ala His Gly Gly Arg Glu Phe Gly Phe Ile Gly Ala Arg Met Arg
                130                 135                 140
 
caa caa cac gct gta gtt act ggt cat tgg caa gat aaa caa gct cat   482
Gln Gln His Ala Val Val Thr Gly His Trp Gln Asp Lys Gln Ala His
            145                 150                 155
 
gaa aga att ggt tca tgg atg agg caa gca gtt tca aaa caa gat act   530
Glu Arg Ile Gly Ser Trp Met Arg Gln Ala Val Ser Lys Gln Asp Thr
        160                 165                 170
 
aga cat tta aag gtt tgt aga ttt gga gat aat atg aga gaa gta gct   578
Arg His Leu Lys Val Cys Arg Phe Gly Asp Asn Met Arg Glu Val Ala
    175                 180                 185
 
gtt act gac ggt gat aaa gta gcc gct caa ata aaa ttc ggt ttt tct   626
Val Thr Asp Gly Asp Lys Val Ala Ala Gln Ile Lys Phe Gly Phe Ser
190                 195                 200                 205
 
gtt aat act tgg gct gtt ggt gat ttg gtt caa gtt gtt aat tct att   674
Val Asn Thr Trp Ala Val Gly Asp Leu Val Gln Val Val Asn Ser Ile
                210                 215                 220
 
tca gat ggt gat gtt aat gct ttg gtt gat gaa tat gaa tct tgt tat   722
Ser Asp Gly Asp Val Asn Ala Leu Val Asp Glu Tyr Glu Ser Cys Tyr
            225                 230                 235
 
act atg act cca gca act caa att cat ggt gag aaa aga caa aat gtt   770
Thr Met Thr Pro Ala Thr Gln Ile His Gly Glu Lys Arg Gln Asn Val
        240                 245                 250
 
ttg gaa gct gct aga att gaa ttg gga atg aaa aga ttt tta gag caa   818
Leu Glu Ala Ala Arg Ile Glu Leu Gly Met Lys Arg Phe Leu Glu Gln
    255                 260                 265
 
ggt ggt ttt cat gct ttt act act act ttt gaa gat ttg cat ggt tta   866
Gly Gly Phe His Ala Phe Thr Thr Thr Phe Glu Asp Leu His Gly Leu
270                 275                 280                 285
 
aaa caa ttg cca ggt tta gct gtt caa aga tta atg caa caa ggt tat   914
Lys Gln Leu Pro Gly Leu Ala Val Gln Arg Leu Met Gln Gln Gly Tyr
                290                 295                 300
 
ggt ttc gct ggt gag ggt gat tgg aaa act gct gct ttg ttg aga att   962
Gly Phe Ala Gly Glu Gly Asp Trp Lys Thr Ala Ala Leu Leu Arg Ile
            305                 310                 315
 
atg aaa gta atg tca act ggt ttg caa ggt ggt act tct ttt atg gaa   1010
Met Lys Val Met Ser Thr Gly Leu Gln Gly Gly Thr Ser Phe Met Glu
        320                 325                 330
 
gat tat act tat cat ttt gaa aaa ggt aat gat ttg gtt ttg ggt tct   1058
Asp Tyr Thr Tyr His Phe Glu Lys Gly Asn Asp Leu Val Leu Gly Ser
    335                 340                 345
 
cac atg ttg gaa gtt tgt cca tct att gct gtt gaa gaa aaa cca att   1106
His Met Leu Glu Val Cys Pro Ser Ile Ala Val Glu Glu Lys Pro Ile
350                 355                 360                 365
 
ttg gat gtt caa cat ttg gga att ggt ggt aaa gat gat cca gct aga   1154
Leu Asp Val Gln His Leu Gly Ile Gly Gly Lys Asp Asp Pro Ala Arg
                370                 375                 380
 
ttg att ttt aat act caa act ggt cca gct att gtt gct tct ttg att   1202
Leu Ile Phe Asn Thr Gln Thr Gly Pro Ala Ile Val Ala Ser Leu Ile
            385                 390                 395
 
gat ttg ggt gat aga tat aga ttg ttg gtt aat tgt att gat act gtt   1250
Asp Leu Gly Asp Arg Tyr Arg Leu Leu Val Asn Cys Ile Asp Thr Val
        400                 405                 410
 
aaa act cca cat tct ttg cca aaa ttg cca gtt gct aat gca ttg tgg   1298
Lys Thr Pro His Ser Leu Pro Lys Leu Pro Val Ala Asn Ala Leu Trp
    415                 420                 425
 
aaa gct caa cca gat ttg cca act gct tct gag gct tgg att ttg gct   1346
Lys Ala Gln Pro Asp Leu Pro Thr Ala Ser Glu Ala Trp Ile Leu Ala
430                 435                 440                 445
 
ggt ggt gct cat cac act gtt ttt agt cat gct tta aat tta aat gat   1394
Gly Gly Ala His His Thr Val Phe Ser His Ala Leu Asn Leu Asn Asp
                450                 455                 460
 
atg aga caa ttt gct gaa atg cat gac att gaa att act gta att gat   1442
Met Arg Gln Phe Ala Glu Met His Asp Ile Glu Ile Thr Val Ile Asp
            465                 470                 475
 
aat gat act agg ttg cca gct ttt aaa gat gct ttg aga tgg aat gaa   1490
Asn Asp Thr Arg Leu Pro Ala Phe Lys Asp Ala Leu Arg Trp Asn Glu
        480                 485                 490
 
gtt tat tat ggt ttt agg aga gaattccgat g                          1522
Val Tyr Tyr Gly Phe Arg Arg
    495                 500
 

<210> 204
<211> 500
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in E. coli

<400> 204
Met Thr Ile Phe Asp Asn Tyr Glu Val Trp Phe Val Ile Gly Ser Gln
 1               5                  10                  15      
His Leu Tyr Gly Pro Glu Thr Leu Arg Gln Val Thr Gln His Ala Glu
            20                  25                  30          
His Val Val Asn Ala Leu Asn Thr Glu Ala Lys Leu Pro Cys Lys Leu
        35                  40                  45              
Val Leu Lys Pro Leu Gly Thr Thr Pro Asp Glu Ile Thr Ala Ile Cys
    50                  55                  60                  
Arg Asp Ala Asn Tyr Asp Asp Pro Cys Ala Gly Leu Val Val Trp Leu
65                  70                  75                  80  
His Thr Phe Ser Pro Ala Lys Met Trp Ile Asn Gly Leu Thr Met Leu
                85                  90                  95      
Asn Lys Pro Leu Leu Gln Phe His Thr Gln Phe Asn Ala Ala Leu Pro
            100                 105                 110         
Trp Asp Ser Ile Asp Met Asp Phe Met Asn Leu Asn Gln Thr Ala His
        115                 120                 125             
Gly Gly Arg Glu Phe Gly Phe Ile Gly Ala Arg Met Arg Gln Gln His
    130                 135                 140                 
Ala Val Val Thr Gly His Trp Gln Asp Lys Gln Ala His Glu Arg Ile
145                 150                 155                 160 
Gly Ser Trp Met Arg Gln Ala Val Ser Lys Gln Asp Thr Arg His Leu
                165                 170                 175     
Lys Val Cys Arg Phe Gly Asp Asn Met Arg Glu Val Ala Val Thr Asp
            180                 185                 190         
Gly Asp Lys Val Ala Ala Gln Ile Lys Phe Gly Phe Ser Val Asn Thr
        195                 200                 205             
Trp Ala Val Gly Asp Leu Val Gln Val Val Asn Ser Ile Ser Asp Gly
    210                 215                 220                 
Asp Val Asn Ala Leu Val Asp Glu Tyr Glu Ser Cys Tyr Thr Met Thr
225                 230                 235                 240 
Pro Ala Thr Gln Ile His Gly Glu Lys Arg Gln Asn Val Leu Glu Ala
                245                 250                 255     
Ala Arg Ile Glu Leu Gly Met Lys Arg Phe Leu Glu Gln Gly Gly Phe
            260                 265                 270         
His Ala Phe Thr Thr Thr Phe Glu Asp Leu His Gly Leu Lys Gln Leu
        275                 280                 285             
Pro Gly Leu Ala Val Gln Arg Leu Met Gln Gln Gly Tyr Gly Phe Ala
    290                 295                 300                 
Gly Glu Gly Asp Trp Lys Thr Ala Ala Leu Leu Arg Ile Met Lys Val
305                 310                 315                 320 
Met Ser Thr Gly Leu Gln Gly Gly Thr Ser Phe Met Glu Asp Tyr Thr
                325                 330                 335     
Tyr His Phe Glu Lys Gly Asn Asp Leu Val Leu Gly Ser His Met Leu
            340                 345                 350         
Glu Val Cys Pro Ser Ile Ala Val Glu Glu Lys Pro Ile Leu Asp Val
        355                 360                 365             
Gln His Leu Gly Ile Gly Gly Lys Asp Asp Pro Ala Arg Leu Ile Phe
    370                 375                 380                 
Asn Thr Gln Thr Gly Pro Ala Ile Val Ala Ser Leu Ile Asp Leu Gly
385                 390                 395                 400 
Asp Arg Tyr Arg Leu Leu Val Asn Cys Ile Asp Thr Val Lys Thr Pro
                405                 410                 415     
His Ser Leu Pro Lys Leu Pro Val Ala Asn Ala Leu Trp Lys Ala Gln
            420                 425                 430         
Pro Asp Leu Pro Thr Ala Ser Glu Ala Trp Ile Leu Ala Gly Gly Ala
        435                 440                 445             
His His Thr Val Phe Ser His Ala Leu Asn Leu Asn Asp Met Arg Gln
    450                 455                 460                 
Phe Ala Glu Met His Asp Ile Glu Ile Thr Val Ile Asp Asn Asp Thr
465                 470                 475                 480 
Arg Leu Pro Ala Phe Lys Asp Ala Leu Arg Trp Asn Glu Val Tyr Tyr
                485                 490                 495     
Gly Phe Arg Arg
            500 


<210> 205
<211> 1528
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in E. coli

<220> 
<221> CDS            
<222> (15)...(1514)

<400> 205
gaatactcca tatg atg act att ttt gat aat tat gaa gtt tgg ttt gta   50
                Met Thr Ile Phe Asp Asn Tyr Glu Val Trp Phe Val
                 1               5                   10
 
att ggt tca caa cat ttg tat ggt cca gaa act cta aga caa gtt act   98
Ile Gly Ser Gln His Leu Tyr Gly Pro Glu Thr Leu Arg Gln Val Thr
         15                  20                  25
 
caa cat gct gaa cac gta gtt aat gct tta aat act gaa gct aaa ttg   146
Gln His Ala Glu His Val Val Asn Ala Leu Asn Thr Glu Ala Lys Leu
     30                  35                  40
 
cca tgt aaa tta gtt tta aaa cca ttg ggt act act cca gat gaa att   194
Pro Cys Lys Leu Val Leu Lys Pro Leu Gly Thr Thr Pro Asp Glu Ile
 45                  50                  55                  60
 
act gct att tgt aga gat gct aat tat gat gat cca tgt gct ggt tta   242
Thr Ala Ile Cys Arg Asp Ala Asn Tyr Asp Asp Pro Cys Ala Gly Leu
                 65                  70                  75
 
gtt gtt tgg ttg cat act ttt tca cca gct aaa atg tgg att aat gga   290
Val Val Trp Leu His Thr Phe Ser Pro Ala Lys Met Trp Ile Asn Gly
             80                  85                  90
 
ttg act atg tta aat aaa cca ttg ttg caa ttt cat act caa ttt aat   338
Leu Thr Met Leu Asn Lys Pro Leu Leu Gln Phe His Thr Gln Phe Asn
         95                 100                 105
 
gct gct ttg cca tgg gat tct att gat atg gat ttt atg aat tta aat   386
Ala Ala Leu Pro Trp Asp Ser Ile Asp Met Asp Phe Met Asn Leu Asn
    110                 115                 120
 
caa act gct cat ggt ggt aga gag ttc ggt ttt att gga gct aga atg   434
Gln Thr Ala His Gly Gly Arg Glu Phe Gly Phe Ile Gly Ala Arg Met
125                 130                 135                 140
 
aga caa caa cac gct gta gtt act ggt cat tgg caa gat aaa caa gct   482
Arg Gln Gln His Ala Val Val Thr Gly His Trp Gln Asp Lys Gln Ala
                145                 150                 155
 
cat gaa aga att ggt tca tgg atg agg caa gca gtt tca aaa caa gat   530
His Glu Arg Ile Gly Ser Trp Met Arg Gln Ala Val Ser Lys Gln Asp
            160                 165                 170
 
act aga cat tta aag gtt tgt aga ttt gga gat aat atg aga gaa gta   578
Thr Arg His Leu Lys Val Cys Arg Phe Gly Asp Asn Met Arg Glu Val
        175                 180                 185
 
gct gtt act gac ggt gat aaa gta gcc gct caa ata aaa ttc ggt ttt   626
Ala Val Thr Asp Gly Asp Lys Val Ala Ala Gln Ile Lys Phe Gly Phe
    190                 195                 200
 
tct gtt aat act tgg gct gtt ggt gat ttg gtt caa gtt gtt aat tct   674
Ser Val Asn Thr Trp Ala Val Gly Asp Leu Val Gln Val Val Asn Ser
205                 210                 215                 220
 
att tca gat ggt gat gtt aat gct ttg gtt gat gaa tat gaa tct tgt   722
Ile Ser Asp Gly Asp Val Asn Ala Leu Val Asp Glu Tyr Glu Ser Cys
                225                 230                 235
 
tat act atg act cca gca act caa att cat ggt gag aaa aga caa aat   770
Tyr Thr Met Thr Pro Ala Thr Gln Ile His Gly Glu Lys Arg Gln Asn
            240                 245                 250
 
gtt ttg gaa gct gct aga att gaa ttg gga atg aaa aga ttt tta gag   818
Val Leu Glu Ala Ala Arg Ile Glu Leu Gly Met Lys Arg Phe Leu Glu
        255                 260                 265
 
caa ggt ggt ttt cat gct ttt act act act ttt gaa gat ttg cat ggt   866
Gln Gly Gly Phe His Ala Phe Thr Thr Thr Phe Glu Asp Leu His Gly
    270                 275                 280
 
tta aaa caa ttg cca ggt tta gct gtt caa aga tta atg caa caa ggt   914
Leu Lys Gln Leu Pro Gly Leu Ala Val Gln Arg Leu Met Gln Gln Gly
285                 290                 295                 300
 
tat ggt ttc gct ggt gag ggt gat tgg aaa act gct gct ttg ttg aga   962
Tyr Gly Phe Ala Gly Glu Gly Asp Trp Lys Thr Ala Ala Leu Leu Arg
                305                 310                 315
 
att atg aaa gta atg tca act ggt ttg caa ggt ggt act tct ttt atg   1010
Ile Met Lys Val Met Ser Thr Gly Leu Gln Gly Gly Thr Ser Phe Met
            320                 325                 330
 
gaa gat tat act tat cat ttt gaa aaa ggt aat gat ttg gtt ttg ggt   1058
Glu Asp Tyr Thr Tyr His Phe Glu Lys Gly Asn Asp Leu Val Leu Gly
        335                 340                 345
 
tct cac atg ttg gaa gtt tgt cca tct att gct gtt gaa gaa aaa cca   1106
Ser His Met Leu Glu Val Cys Pro Ser Ile Ala Val Glu Glu Lys Pro
    350                 355                 360
 
att ttg gat gtt caa cat ttg gga att ggt ggt aaa gat gat cca gct   1154
Ile Leu Asp Val Gln His Leu Gly Ile Gly Gly Lys Asp Asp Pro Ala
365                 370                 375                 380
 
aga ttg att ttt aat act caa act ggt cca gct att gtt gct tct ttg   1202
Arg Leu Ile Phe Asn Thr Gln Thr Gly Pro Ala Ile Val Ala Ser Leu
                385                 390                 395
 
att gat ttg ggt gat aga tat aga ttg ttg gtt aat tgt att gat act   1250
Ile Asp Leu Gly Asp Arg Tyr Arg Leu Leu Val Asn Cys Ile Asp Thr
            400                 405                 410
 
gtt aaa act cca cat tct ttg cca aaa ttg cca gtt gct aat gca ttg   1298
Val Lys Thr Pro His Ser Leu Pro Lys Leu Pro Val Ala Asn Ala Leu
        415                 420                 425
 
tgg aaa gct caa cca gat ttg cca act gct tct gag gct tgg att ttg   1346
Trp Lys Ala Gln Pro Asp Leu Pro Thr Ala Ser Glu Ala Trp Ile Leu
    430                 435                 440
 
gct ggt ggt gct cat cac act gtt ttt agt cat gct tta aat tta aat   1394
Ala Gly Gly Ala His His Thr Val Phe Ser His Ala Leu Asn Leu Asn
445                 450                 455                 460
 
gat atg aga caa ttt gct gaa atg cat gac att gaa att act gta att   1442
Asp Met Arg Gln Phe Ala Glu Met His Asp Ile Glu Ile Thr Val Ile
                465                 470                 475
 
gat aat gat act agg ttg cca gct ttt aaa gat gct ttg aga tgg aat   1490
Asp Asn Asp Thr Arg Leu Pro Ala Phe Lys Asp Ala Leu Arg Trp Asn
            480                 485                 490
 
gaa gtt tat tat ggt ttt agg aga actagtcgat gcct                   1528
Glu Val Tyr Tyr Gly Phe Arg Arg
        495                 500
 

<210> 206
<211> 500
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in E. coli

<400> 206
Met Thr Ile Phe Asp Asn Tyr Glu Val Trp Phe Val Ile Gly Ser Gln
 1               5                  10                  15      
His Leu Tyr Gly Pro Glu Thr Leu Arg Gln Val Thr Gln His Ala Glu
            20                  25                  30          
His Val Val Asn Ala Leu Asn Thr Glu Ala Lys Leu Pro Cys Lys Leu
        35                  40                  45              
Val Leu Lys Pro Leu Gly Thr Thr Pro Asp Glu Ile Thr Ala Ile Cys
    50                  55                  60                  
Arg Asp Ala Asn Tyr Asp Asp Pro Cys Ala Gly Leu Val Val Trp Leu
65                  70                  75                  80  
His Thr Phe Ser Pro Ala Lys Met Trp Ile Asn Gly Leu Thr Met Leu
                85                  90                  95      
Asn Lys Pro Leu Leu Gln Phe His Thr Gln Phe Asn Ala Ala Leu Pro
            100                 105                 110         
Trp Asp Ser Ile Asp Met Asp Phe Met Asn Leu Asn Gln Thr Ala His
        115                 120                 125             
Gly Gly Arg Glu Phe Gly Phe Ile Gly Ala Arg Met Arg Gln Gln His
    130                 135                 140                 
Ala Val Val Thr Gly His Trp Gln Asp Lys Gln Ala His Glu Arg Ile
145                 150                 155                 160 
Gly Ser Trp Met Arg Gln Ala Val Ser Lys Gln Asp Thr Arg His Leu
                165                 170                 175     
Lys Val Cys Arg Phe Gly Asp Asn Met Arg Glu Val Ala Val Thr Asp
            180                 185                 190         
Gly Asp Lys Val Ala Ala Gln Ile Lys Phe Gly Phe Ser Val Asn Thr
        195                 200                 205             
Trp Ala Val Gly Asp Leu Val Gln Val Val Asn Ser Ile Ser Asp Gly
    210                 215                 220                 
Asp Val Asn Ala Leu Val Asp Glu Tyr Glu Ser Cys Tyr Thr Met Thr
225                 230                 235                 240 
Pro Ala Thr Gln Ile His Gly Glu Lys Arg Gln Asn Val Leu Glu Ala
                245                 250                 255     
Ala Arg Ile Glu Leu Gly Met Lys Arg Phe Leu Glu Gln Gly Gly Phe
            260                 265                 270         
His Ala Phe Thr Thr Thr Phe Glu Asp Leu His Gly Leu Lys Gln Leu
        275                 280                 285             
Pro Gly Leu Ala Val Gln Arg Leu Met Gln Gln Gly Tyr Gly Phe Ala
    290                 295                 300                 
Gly Glu Gly Asp Trp Lys Thr Ala Ala Leu Leu Arg Ile Met Lys Val
305                 310                 315                 320 
Met Ser Thr Gly Leu Gln Gly Gly Thr Ser Phe Met Glu Asp Tyr Thr
                325                 330                 335     
Tyr His Phe Glu Lys Gly Asn Asp Leu Val Leu Gly Ser His Met Leu
            340                 345                 350         
Glu Val Cys Pro Ser Ile Ala Val Glu Glu Lys Pro Ile Leu Asp Val
        355                 360                 365             
Gln His Leu Gly Ile Gly Gly Lys Asp Asp Pro Ala Arg Leu Ile Phe
    370                 375                 380                 
Asn Thr Gln Thr Gly Pro Ala Ile Val Ala Ser Leu Ile Asp Leu Gly
385                 390                 395                 400 
Asp Arg Tyr Arg Leu Leu Val Asn Cys Ile Asp Thr Val Lys Thr Pro
                405                 410                 415     
His Ser Leu Pro Lys Leu Pro Val Ala Asn Ala Leu Trp Lys Ala Gln
            420                 425                 430         
Pro Asp Leu Pro Thr Ala Ser Glu Ala Trp Ile Leu Ala Gly Gly Ala
        435                 440                 445             
His His Thr Val Phe Ser His Ala Leu Asn Leu Asn Asp Met Arg Gln
    450                 455                 460                 
Phe Ala Glu Met His Asp Ile Glu Ile Thr Val Ile Asp Asn Asp Thr
465                 470                 475                 480 
Arg Leu Pro Ala Phe Lys Asp Ala Leu Arg Trp Asn Glu Val Tyr Tyr
                485                 490                 495     
Gly Phe Arg Arg
            500 


<210> 207
<211> 1500
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in P. pastoris

<220> 
<221> CDS            
<222> (1)...(1500)

<400> 207
atg act att ttt gat aat tat gaa gtt tgg ttt gtt att gga tct caa   48
Met Thr Ile Phe Asp Asn Tyr Glu Val Trp Phe Val Ile Gly Ser Gln
 1               5                   10                  15
 
cat ttg tat gga cca gaa act tta aga caa gtt act caa cat gct gaa   96
His Leu Tyr Gly Pro Glu Thr Leu Arg Gln Val Thr Gln His Ala Glu
             20                  25                  30
 
cac gtg gtt aac gct tta aat act gaa gct aaa ttg cca tgt aaa ttg   144
His Val Val Asn Ala Leu Asn Thr Glu Ala Lys Leu Pro Cys Lys Leu
         35                  40                  45
 
gtt ttg aag cca ttg ggt act act cca gat gaa att act gct att tgt   192
Val Leu Lys Pro Leu Gly Thr Thr Pro Asp Glu Ile Thr Ala Ile Cys
     50                  55                  60
 
aga gat gct aat tat gat gac cca tgt gct gga ttg gtt gtt tgg ttg   240
Arg Asp Ala Asn Tyr Asp Asp Pro Cys Ala Gly Leu Val Val Trp Leu
 65                  70                  75                  80
 
cat act ttt tct cca gct aaa atg tgg att aat gga ttg act atg tta   288
His Thr Phe Ser Pro Ala Lys Met Trp Ile Asn Gly Leu Thr Met Leu
                 85                  90                  95
 
aat aaa cct ttg ttg caa ttt cat act caa ttt aac gct gct ttg cca   336
Asn Lys Pro Leu Leu Gln Phe His Thr Gln Phe Asn Ala Ala Leu Pro
            100                 105                 110
 
tgg gat tct att gat atg gat ttt atg aat tta aat caa act gct cat   384
Trp Asp Ser Ile Asp Met Asp Phe Met Asn Leu Asn Gln Thr Ala His
        115                 120                 125
 
gga ggt aga gaa ttt ggt ttt atc gga gca aga atg aga caa caa cat   432
Gly Gly Arg Glu Phe Gly Phe Ile Gly Ala Arg Met Arg Gln Gln His
    130                 135                 140
 
gct gtg gtt act gga cat tgg caa gat aaa caa gct cat gaa aga att   480
Ala Val Val Thr Gly His Trp Gln Asp Lys Gln Ala His Glu Arg Ile
145                 150                 155                 160
 
gga tct tgg atg aga cag gca gtt tct aaa caa gat act aga cat tta   528
Gly Ser Trp Met Arg Gln Ala Val Ser Lys Gln Asp Thr Arg His Leu
                165                 170                 175
 
aaa gtt tgt aga ttt ggt gat aat atg aga gaa gtt gca gtt aca gat   576
Lys Val Cys Arg Phe Gly Asp Asn Met Arg Glu Val Ala Val Thr Asp
            180                 185                 190
 
gga gat aaa gtg gct gca caa att aaa ttc gga ttt tct gtt aat act   624
Gly Asp Lys Val Ala Ala Gln Ile Lys Phe Gly Phe Ser Val Asn Thr
        195                 200                 205
 
tgg gct gtt gga gat ttg gtt caa gtt gtt aat tct att tct gat gga   672
Trp Ala Val Gly Asp Leu Val Gln Val Val Asn Ser Ile Ser Asp Gly
    210                 215                 220
 
gac gtt aat gca ttg gtt gat gaa tat gaa tct tgt tat act atg act   720
Asp Val Asn Ala Leu Val Asp Glu Tyr Glu Ser Cys Tyr Thr Met Thr
225                 230                 235                 240
 
cca gca act caa att cat gga gaa aag aga caa aat gtt tta gaa gct   768
Pro Ala Thr Gln Ile His Gly Glu Lys Arg Gln Asn Val Leu Glu Ala
                245                 250                 255
 
gct aga att gaa ttg gga atg aaa aga ttt tta gaa caa gga gga ttt   816
Ala Arg Ile Glu Leu Gly Met Lys Arg Phe Leu Glu Gln Gly Gly Phe
            260                 265                 270
 
cat gct ttt act act act ttt gag gat ttg cat gga tta aaa caa ttg   864
His Ala Phe Thr Thr Thr Phe Glu Asp Leu His Gly Leu Lys Gln Leu
        275                 280                 285
 
cca gga tta gct gtt caa aga ttg atg caa caa gga tat gga ttc gct   912
Pro Gly Leu Ala Val Gln Arg Leu Met Gln Gln Gly Tyr Gly Phe Ala
    290                 295                 300
 
ggt gaa gga gat tgg aaa act gct gct ttg ttg aga att atg aaa gtt   960
Gly Glu Gly Asp Trp Lys Thr Ala Ala Leu Leu Arg Ile Met Lys Val
305                 310                 315                 320
 
atg tct act gga ttg caa gga gga aca tct ttt atg gaa gat tat act   1008
Met Ser Thr Gly Leu Gln Gly Gly Thr Ser Phe Met Glu Asp Tyr Thr
                325                 330                 335
 
tat cat ttt gag aaa gga aat gat ttg gtt ttg gga tct cac atg tta   1056
Tyr His Phe Glu Lys Gly Asn Asp Leu Val Leu Gly Ser His Met Leu
            340                 345                 350
 
gaa gtt tgt cca tct att gct gtt gaa gaa aag cca att ttg gat gtt   1104
Glu Val Cys Pro Ser Ile Ala Val Glu Glu Lys Pro Ile Leu Asp Val
        355                 360                 365
 
caa cat ttg gga att gga gga aaa gat gat cca gct aga ttg att ttt   1152
Gln His Leu Gly Ile Gly Gly Lys Asp Asp Pro Ala Arg Leu Ile Phe
    370                 375                 380
 
aat act caa act gga cca gct att gtt gct tca ttg att gat ttg gga   1200
Asn Thr Gln Thr Gly Pro Ala Ile Val Ala Ser Leu Ile Asp Leu Gly
385                 390                 395                 400
 
gat aga tat aga ttg ttg gtt aat tgt att gat act gtt aaa act cca   1248
Asp Arg Tyr Arg Leu Leu Val Asn Cys Ile Asp Thr Val Lys Thr Pro
                405                 410                 415
 
cat tca ttg cca aaa tta cct gtt gct aat gca ttg tgg aaa gct caa   1296
His Ser Leu Pro Lys Leu Pro Val Ala Asn Ala Leu Trp Lys Ala Gln
            420                 425                 430
 
cca gat ttg cca act gca tct gaa gcc tgg att cta gct gga ggt gct   1344
Pro Asp Leu Pro Thr Ala Ser Glu Ala Trp Ile Leu Ala Gly Gly Ala
        435                 440                 445
 
cat cat act gtt ttt agt cat gct tta aat tta aat gat atg aga caa   1392
His His Thr Val Phe Ser His Ala Leu Asn Leu Asn Asp Met Arg Gln
    450                 455                 460
 
ttc gct gaa atg cat gac att gaa att act gtt att gat aat gat act   1440
Phe Ala Glu Met His Asp Ile Glu Ile Thr Val Ile Asp Asn Asp Thr
465                 470                 475                 480
 
aga ttg cca gct ttt aaa gat gct ttg aga tgg aat gaa gtt tat tat   1488
Arg Leu Pro Ala Phe Lys Asp Ala Leu Arg Trp Asn Glu Val Tyr Tyr
                485                 490                 495
 
gga ttt aga aga                                                   1500
Gly Phe Arg Arg
            500
 

<210> 208
<211> 500
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in P. pastoris

<400> 208
Met Thr Ile Phe Asp Asn Tyr Glu Val Trp Phe Val Ile Gly Ser Gln
 1               5                  10                  15      
His Leu Tyr Gly Pro Glu Thr Leu Arg Gln Val Thr Gln His Ala Glu
            20                  25                  30          
His Val Val Asn Ala Leu Asn Thr Glu Ala Lys Leu Pro Cys Lys Leu
        35                  40                  45              
Val Leu Lys Pro Leu Gly Thr Thr Pro Asp Glu Ile Thr Ala Ile Cys
    50                  55                  60                  
Arg Asp Ala Asn Tyr Asp Asp Pro Cys Ala Gly Leu Val Val Trp Leu
65                  70                  75                  80  
His Thr Phe Ser Pro Ala Lys Met Trp Ile Asn Gly Leu Thr Met Leu
                85                  90                  95      
Asn Lys Pro Leu Leu Gln Phe His Thr Gln Phe Asn Ala Ala Leu Pro
            100                 105                 110         
Trp Asp Ser Ile Asp Met Asp Phe Met Asn Leu Asn Gln Thr Ala His
        115                 120                 125             
Gly Gly Arg Glu Phe Gly Phe Ile Gly Ala Arg Met Arg Gln Gln His
    130                 135                 140                 
Ala Val Val Thr Gly His Trp Gln Asp Lys Gln Ala His Glu Arg Ile
145                 150                 155                 160 
Gly Ser Trp Met Arg Gln Ala Val Ser Lys Gln Asp Thr Arg His Leu
                165                 170                 175     
Lys Val Cys Arg Phe Gly Asp Asn Met Arg Glu Val Ala Val Thr Asp
            180                 185                 190         
Gly Asp Lys Val Ala Ala Gln Ile Lys Phe Gly Phe Ser Val Asn Thr
        195                 200                 205             
Trp Ala Val Gly Asp Leu Val Gln Val Val Asn Ser Ile Ser Asp Gly
    210                 215                 220                 
Asp Val Asn Ala Leu Val Asp Glu Tyr Glu Ser Cys Tyr Thr Met Thr
225                 230                 235                 240 
Pro Ala Thr Gln Ile His Gly Glu Lys Arg Gln Asn Val Leu Glu Ala
                245                 250                 255     
Ala Arg Ile Glu Leu Gly Met Lys Arg Phe Leu Glu Gln Gly Gly Phe
            260                 265                 270         
His Ala Phe Thr Thr Thr Phe Glu Asp Leu His Gly Leu Lys Gln Leu
        275                 280                 285             
Pro Gly Leu Ala Val Gln Arg Leu Met Gln Gln Gly Tyr Gly Phe Ala
    290                 295                 300                 
Gly Glu Gly Asp Trp Lys Thr Ala Ala Leu Leu Arg Ile Met Lys Val
305                 310                 315                 320 
Met Ser Thr Gly Leu Gln Gly Gly Thr Ser Phe Met Glu Asp Tyr Thr
                325                 330                 335     
Tyr His Phe Glu Lys Gly Asn Asp Leu Val Leu Gly Ser His Met Leu
            340                 345                 350         
Glu Val Cys Pro Ser Ile Ala Val Glu Glu Lys Pro Ile Leu Asp Val
        355                 360                 365             
Gln His Leu Gly Ile Gly Gly Lys Asp Asp Pro Ala Arg Leu Ile Phe
    370                 375                 380                 
Asn Thr Gln Thr Gly Pro Ala Ile Val Ala Ser Leu Ile Asp Leu Gly
385                 390                 395                 400 
Asp Arg Tyr Arg Leu Leu Val Asn Cys Ile Asp Thr Val Lys Thr Pro
                405                 410                 415     
His Ser Leu Pro Lys Leu Pro Val Ala Asn Ala Leu Trp Lys Ala Gln
            420                 425                 430         
Pro Asp Leu Pro Thr Ala Ser Glu Ala Trp Ile Leu Ala Gly Gly Ala
        435                 440                 445             
His His Thr Val Phe Ser His Ala Leu Asn Leu Asn Asp Met Arg Gln
    450                 455                 460                 
Phe Ala Glu Met His Asp Ile Glu Ile Thr Val Ile Asp Asn Asp Thr
465                 470                 475                 480 
Arg Leu Pro Ala Phe Lys Asp Ala Leu Arg Trp Asn Glu Val Tyr Tyr
                485                 490                 495     
Gly Phe Arg Arg
            500 


<210> 209
<211> 1522
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in P. pastoris

<220> 
<221> CDS            
<222> (12)...(1511)

<400> 209
tactcaagct t atg act att ttt gat aat tat gaa gtt tgg ttt gtt att  50
             Met Thr Ile Phe Asp Asn Tyr Glu Val Trp Phe Val Ile
              1               5                   10
 
gga tct caa cat ttg tat gga cca gaa act tta aga caa gtt act caa   98
Gly Ser Gln His Leu Tyr Gly Pro Glu Thr Leu Arg Gln Val Thr Gln
     15                  20                  25
 
cat gct gaa cac gtg gtt aac gct tta aat act gaa gct aaa ttg cca   146
His Ala Glu His Val Val Asn Ala Leu Asn Thr Glu Ala Lys Leu Pro
 30                  35                  40                  45
 
tgt aaa ttg gtt ttg aag cca ttg ggt act act cca gat gaa att act   194
Cys Lys Leu Val Leu Lys Pro Leu Gly Thr Thr Pro Asp Glu Ile Thr
                 50                  55                  60
 
gct att tgt aga gat gct aat tat gat gac cca tgt gct gga ttg gtt   242
Ala Ile Cys Arg Asp Ala Asn Tyr Asp Asp Pro Cys Ala Gly Leu Val
             65                  70                  75
 
gtt tgg ttg cat act ttt tct cca gct aaa atg tgg att aat gga ttg   290
Val Trp Leu His Thr Phe Ser Pro Ala Lys Met Trp Ile Asn Gly Leu
         80                  85                  90
 
act atg tta aat aaa cct ttg ttg caa ttt cat act caa ttt aac gct   338
Thr Met Leu Asn Lys Pro Leu Leu Gln Phe His Thr Gln Phe Asn Ala
     95                 100                 105
 
gct ttg cca tgg gat tct att gat atg gat ttt atg aat tta aat caa   386
Ala Leu Pro Trp Asp Ser Ile Asp Met Asp Phe Met Asn Leu Asn Gln
110                 115                 120                 125
 
act gct cat gga ggt aga gaa ttt ggt ttt atc gga gca aga atg aga   434
Thr Ala His Gly Gly Arg Glu Phe Gly Phe Ile Gly Ala Arg Met Arg
                130                 135                 140
 
caa caa cat gct gtg gtt act gga cat tgg caa gat aaa caa gct cat   482
Gln Gln His Ala Val Val Thr Gly His Trp Gln Asp Lys Gln Ala His
            145                 150                 155
 
gaa aga att gga tct tgg atg aga cag gca gtt tct aaa caa gat act   530
Glu Arg Ile Gly Ser Trp Met Arg Gln Ala Val Ser Lys Gln Asp Thr
        160                 165                 170
 
aga cat tta aaa gtt tgt aga ttt ggt gat aat atg aga gaa gtt gca   578
Arg His Leu Lys Val Cys Arg Phe Gly Asp Asn Met Arg Glu Val Ala
    175                 180                 185
 
gtt aca gat gga gat aaa gtg gct gca caa att aaa ttc gga ttt tct   626
Val Thr Asp Gly Asp Lys Val Ala Ala Gln Ile Lys Phe Gly Phe Ser
190                 195                 200                 205
 
gtt aat act tgg gct gtt gga gat ttg gtt caa gtt gtt aat tct att   674
Val Asn Thr Trp Ala Val Gly Asp Leu Val Gln Val Val Asn Ser Ile
                210                 215                 220
 
tct gat gga gac gtt aat gca ttg gtt gat gaa tat gaa tct tgt tat   722
Ser Asp Gly Asp Val Asn Ala Leu Val Asp Glu Tyr Glu Ser Cys Tyr
            225                 230                 235
 
act atg act cca gca act caa att cat gga gaa aag aga caa aat gtt   770
Thr Met Thr Pro Ala Thr Gln Ile His Gly Glu Lys Arg Gln Asn Val
        240                 245                 250
 
tta gaa gct gct aga att gaa ttg gga atg aaa aga ttt tta gaa caa   818
Leu Glu Ala Ala Arg Ile Glu Leu Gly Met Lys Arg Phe Leu Glu Gln
    255                 260                 265
 
gga gga ttt cat gct ttt act act act ttt gag gat ttg cat gga tta   866
Gly Gly Phe His Ala Phe Thr Thr Thr Phe Glu Asp Leu His Gly Leu
270                 275                 280                 285
 
aaa caa ttg cca gga tta gct gtt caa aga ttg atg caa caa gga tat   914
Lys Gln Leu Pro Gly Leu Ala Val Gln Arg Leu Met Gln Gln Gly Tyr
                290                 295                 300
 
gga ttc gct ggt gaa gga gat tgg aaa act gct gct ttg ttg aga att   962
Gly Phe Ala Gly Glu Gly Asp Trp Lys Thr Ala Ala Leu Leu Arg Ile
            305                 310                 315
 
atg aaa gtt atg tct act gga ttg caa gga gga aca tct ttt atg gaa   1010
Met Lys Val Met Ser Thr Gly Leu Gln Gly Gly Thr Ser Phe Met Glu
        320                 325                 330
 
gat tat act tat cat ttt gag aaa gga aat gat ttg gtt ttg gga tct   1058
Asp Tyr Thr Tyr His Phe Glu Lys Gly Asn Asp Leu Val Leu Gly Ser
    335                 340                 345
 
cac atg tta gaa gtt tgt cca tct att gct gtt gaa gaa aag cca att   1106
His Met Leu Glu Val Cys Pro Ser Ile Ala Val Glu Glu Lys Pro Ile
350                 355                 360                 365
 
ttg gat gtt caa cat ttg gga att gga gga aaa gat gat cca gct aga   1154
Leu Asp Val Gln His Leu Gly Ile Gly Gly Lys Asp Asp Pro Ala Arg
                370                 375                 380
 
ttg att ttt aat act caa act gga cca gct att gtt gct tca ttg att   1202
Leu Ile Phe Asn Thr Gln Thr Gly Pro Ala Ile Val Ala Ser Leu Ile
            385                 390                 395
 
gat ttg gga gat aga tat aga ttg ttg gtt aat tgt att gat act gtt   1250
Asp Leu Gly Asp Arg Tyr Arg Leu Leu Val Asn Cys Ile Asp Thr Val
        400                 405                 410
 
aaa act cca cat tca ttg cca aaa tta cct gtt gct aat gca ttg tgg   1298
Lys Thr Pro His Ser Leu Pro Lys Leu Pro Val Ala Asn Ala Leu Trp
    415                 420                 425
 
aaa gct caa cca gat ttg cca act gca tct gaa gcc tgg att cta gct   1346
Lys Ala Gln Pro Asp Leu Pro Thr Ala Ser Glu Ala Trp Ile Leu Ala
430                 435                 440                 445
 
gga ggt gct cat cat act gtt ttt agt cat gct tta aat tta aat gat   1394
Gly Gly Ala His His Thr Val Phe Ser His Ala Leu Asn Leu Asn Asp
                450                 455                 460
 
atg aga caa ttc gct gaa atg cat gac att gaa att act gtt att gat   1442
Met Arg Gln Phe Ala Glu Met His Asp Ile Glu Ile Thr Val Ile Asp
            465                 470                 475
 
aat gat act aga ttg cca gct ttt aaa gat gct ttg aga tgg aat gaa   1490
Asn Asp Thr Arg Leu Pro Ala Phe Lys Asp Ala Leu Arg Trp Asn Glu
        480                 485                 490
 
gtt tat tat gga ttt aga aga gaattccgat g                          1522
Val Tyr Tyr Gly Phe Arg Arg
    495                 500
 

<210> 210
<211> 500
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in P. pastoris

<400> 210
Met Thr Ile Phe Asp Asn Tyr Glu Val Trp Phe Val Ile Gly Ser Gln
 1               5                  10                  15      
His Leu Tyr Gly Pro Glu Thr Leu Arg Gln Val Thr Gln His Ala Glu
            20                  25                  30          
His Val Val Asn Ala Leu Asn Thr Glu Ala Lys Leu Pro Cys Lys Leu
        35                  40                  45              
Val Leu Lys Pro Leu Gly Thr Thr Pro Asp Glu Ile Thr Ala Ile Cys
    50                  55                  60                  
Arg Asp Ala Asn Tyr Asp Asp Pro Cys Ala Gly Leu Val Val Trp Leu
65                  70                  75                  80  
His Thr Phe Ser Pro Ala Lys Met Trp Ile Asn Gly Leu Thr Met Leu
                85                  90                  95      
Asn Lys Pro Leu Leu Gln Phe His Thr Gln Phe Asn Ala Ala Leu Pro
            100                 105                 110         
Trp Asp Ser Ile Asp Met Asp Phe Met Asn Leu Asn Gln Thr Ala His
        115                 120                 125             
Gly Gly Arg Glu Phe Gly Phe Ile Gly Ala Arg Met Arg Gln Gln His
    130                 135                 140                 
Ala Val Val Thr Gly His Trp Gln Asp Lys Gln Ala His Glu Arg Ile
145                 150                 155                 160 
Gly Ser Trp Met Arg Gln Ala Val Ser Lys Gln Asp Thr Arg His Leu
                165                 170                 175     
Lys Val Cys Arg Phe Gly Asp Asn Met Arg Glu Val Ala Val Thr Asp
            180                 185                 190         
Gly Asp Lys Val Ala Ala Gln Ile Lys Phe Gly Phe Ser Val Asn Thr
        195                 200                 205             
Trp Ala Val Gly Asp Leu Val Gln Val Val Asn Ser Ile Ser Asp Gly
    210                 215                 220                 
Asp Val Asn Ala Leu Val Asp Glu Tyr Glu Ser Cys Tyr Thr Met Thr
225                 230                 235                 240 
Pro Ala Thr Gln Ile His Gly Glu Lys Arg Gln Asn Val Leu Glu Ala
                245                 250                 255     
Ala Arg Ile Glu Leu Gly Met Lys Arg Phe Leu Glu Gln Gly Gly Phe
            260                 265                 270         
His Ala Phe Thr Thr Thr Phe Glu Asp Leu His Gly Leu Lys Gln Leu
        275                 280                 285             
Pro Gly Leu Ala Val Gln Arg Leu Met Gln Gln Gly Tyr Gly Phe Ala
    290                 295                 300                 
Gly Glu Gly Asp Trp Lys Thr Ala Ala Leu Leu Arg Ile Met Lys Val
305                 310                 315                 320 
Met Ser Thr Gly Leu Gln Gly Gly Thr Ser Phe Met Glu Asp Tyr Thr
                325                 330                 335     
Tyr His Phe Glu Lys Gly Asn Asp Leu Val Leu Gly Ser His Met Leu
            340                 345                 350         
Glu Val Cys Pro Ser Ile Ala Val Glu Glu Lys Pro Ile Leu Asp Val
        355                 360                 365             
Gln His Leu Gly Ile Gly Gly Lys Asp Asp Pro Ala Arg Leu Ile Phe
    370                 375                 380                 
Asn Thr Gln Thr Gly Pro Ala Ile Val Ala Ser Leu Ile Asp Leu Gly
385                 390                 395                 400 
Asp Arg Tyr Arg Leu Leu Val Asn Cys Ile Asp Thr Val Lys Thr Pro
                405                 410                 415     
His Ser Leu Pro Lys Leu Pro Val Ala Asn Ala Leu Trp Lys Ala Gln
            420                 425                 430         
Pro Asp Leu Pro Thr Ala Ser Glu Ala Trp Ile Leu Ala Gly Gly Ala
        435                 440                 445             
His His Thr Val Phe Ser His Ala Leu Asn Leu Asn Asp Met Arg Gln
    450                 455                 460                 
Phe Ala Glu Met His Asp Ile Glu Ile Thr Val Ile Asp Asn Asp Thr
465                 470                 475                 480 
Arg Leu Pro Ala Phe Lys Asp Ala Leu Arg Trp Asn Glu Val Tyr Tyr
                485                 490                 495     
Gly Phe Arg Arg
            500 


<210> 211
<211> 1528
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in P. pastoris

<220> 
<221> CDS            
<222> (15)...(1514)

<400> 211
gaatactcca tatg atg act att ttt gat aat tat gaa gtt tgg ttt gtt   50
                Met Thr Ile Phe Asp Asn Tyr Glu Val Trp Phe Val
                 1               5                   10
 
att gga tct caa cat ttg tat gga cca gaa act tta aga caa gtt act   98
Ile Gly Ser Gln His Leu Tyr Gly Pro Glu Thr Leu Arg Gln Val Thr
         15                  20                  25
 
caa cat gct gaa cac gtg gtt aac gct tta aat act gaa gct aaa ttg   146
Gln His Ala Glu His Val Val Asn Ala Leu Asn Thr Glu Ala Lys Leu
     30                  35                  40
 
cca tgt aaa ttg gtt ttg aag cca ttg ggt act act cca gat gaa att   194
Pro Cys Lys Leu Val Leu Lys Pro Leu Gly Thr Thr Pro Asp Glu Ile
 45                  50                  55                  60
 
act gct att tgt aga gat gct aat tat gat gac cca tgt gct gga ttg   242
Thr Ala Ile Cys Arg Asp Ala Asn Tyr Asp Asp Pro Cys Ala Gly Leu
                 65                  70                  75
 
gtt gtt tgg ttg cat act ttt tct cca gct aaa atg tgg att aat gga   290
Val Val Trp Leu His Thr Phe Ser Pro Ala Lys Met Trp Ile Asn Gly
             80                  85                  90
 
ttg act atg tta aat aaa cct ttg ttg caa ttt cat act caa ttt aac   338
Leu Thr Met Leu Asn Lys Pro Leu Leu Gln Phe His Thr Gln Phe Asn
         95                 100                 105
 
gct gct ttg cca tgg gat tct att gat atg gat ttt atg aat tta aat   386
Ala Ala Leu Pro Trp Asp Ser Ile Asp Met Asp Phe Met Asn Leu Asn
    110                 115                 120
 
caa act gct cat gga ggt aga gaa ttt ggt ttt atc gga gca aga atg   434
Gln Thr Ala His Gly Gly Arg Glu Phe Gly Phe Ile Gly Ala Arg Met
125                 130                 135                 140
 
aga caa caa cat gct gtg gtt act gga cat tgg caa gat aaa caa gct   482
Arg Gln Gln His Ala Val Val Thr Gly His Trp Gln Asp Lys Gln Ala
                145                 150                 155
 
cat gaa aga att gga tct tgg atg aga cag gca gtt tct aaa caa gat   530
His Glu Arg Ile Gly Ser Trp Met Arg Gln Ala Val Ser Lys Gln Asp
            160                 165                 170
 
act aga cat tta aaa gtt tgt aga ttt ggt gat aat atg aga gaa gtt   578
Thr Arg His Leu Lys Val Cys Arg Phe Gly Asp Asn Met Arg Glu Val
        175                 180                 185
 
gca gtt aca gat gga gat aaa gtg gct gca caa att aaa ttc gga ttt   626
Ala Val Thr Asp Gly Asp Lys Val Ala Ala Gln Ile Lys Phe Gly Phe
    190                 195                 200
 
tct gtt aat act tgg gct gtt gga gat ttg gtt caa gtt gtt aat tct   674
Ser Val Asn Thr Trp Ala Val Gly Asp Leu Val Gln Val Val Asn Ser
205                 210                 215                 220
 
att tct gat gga gac gtt aat gca ttg gtt gat gaa tat gaa tct tgt   722
Ile Ser Asp Gly Asp Val Asn Ala Leu Val Asp Glu Tyr Glu Ser Cys
                225                 230                 235
 
tat act atg act cca gca act caa att cat gga gaa aag aga caa aat   770
Tyr Thr Met Thr Pro Ala Thr Gln Ile His Gly Glu Lys Arg Gln Asn
            240                 245                 250
 
gtt tta gaa gct gct aga att gaa ttg gga atg aaa aga ttt tta gaa   818
Val Leu Glu Ala Ala Arg Ile Glu Leu Gly Met Lys Arg Phe Leu Glu
        255                 260                 265
 
caa gga gga ttt cat gct ttt act act act ttt gag gat ttg cat gga   866
Gln Gly Gly Phe His Ala Phe Thr Thr Thr Phe Glu Asp Leu His Gly
    270                 275                 280
 
tta aaa caa ttg cca gga tta gct gtt caa aga ttg atg caa caa gga   914
Leu Lys Gln Leu Pro Gly Leu Ala Val Gln Arg Leu Met Gln Gln Gly
285                 290                 295                 300
 
tat gga ttc gct ggt gaa gga gat tgg aaa act gct gct ttg ttg aga   962
Tyr Gly Phe Ala Gly Glu Gly Asp Trp Lys Thr Ala Ala Leu Leu Arg
                305                 310                 315
 
att atg aaa gtt atg tct act gga ttg caa gga gga aca tct ttt atg   1010
Ile Met Lys Val Met Ser Thr Gly Leu Gln Gly Gly Thr Ser Phe Met
            320                 325                 330
 
gaa gat tat act tat cat ttt gag aaa gga aat gat ttg gtt ttg gga   1058
Glu Asp Tyr Thr Tyr His Phe Glu Lys Gly Asn Asp Leu Val Leu Gly
        335                 340                 345
 
tct cac atg tta gaa gtt tgt cca tct att gct gtt gaa gaa aag cca   1106
Ser His Met Leu Glu Val Cys Pro Ser Ile Ala Val Glu Glu Lys Pro
    350                 355                 360
 
att ttg gat gtt caa cat ttg gga att gga gga aaa gat gat cca gct   1154
Ile Leu Asp Val Gln His Leu Gly Ile Gly Gly Lys Asp Asp Pro Ala
365                 370                 375                 380
 
aga ttg att ttt aat act caa act gga cca gct att gtt gct tca ttg   1202
Arg Leu Ile Phe Asn Thr Gln Thr Gly Pro Ala Ile Val Ala Ser Leu
                385                 390                 395
 
att gat ttg gga gat aga tat aga ttg ttg gtt aat tgt att gat act   1250
Ile Asp Leu Gly Asp Arg Tyr Arg Leu Leu Val Asn Cys Ile Asp Thr
            400                 405                 410
 
gtt aaa act cca cat tca ttg cca aaa tta cct gtt gct aat gca ttg   1298
Val Lys Thr Pro His Ser Leu Pro Lys Leu Pro Val Ala Asn Ala Leu
        415                 420                 425
 
tgg aaa gct caa cca gat ttg cca act gca tct gaa gcc tgg att cta   1346
Trp Lys Ala Gln Pro Asp Leu Pro Thr Ala Ser Glu Ala Trp Ile Leu
    430                 435                 440
 
gct gga ggt gct cat cat act gtt ttt agt cat gct tta aat tta aat   1394
Ala Gly Gly Ala His His Thr Val Phe Ser His Ala Leu Asn Leu Asn
445                 450                 455                 460
 
gat atg aga caa ttc gct gaa atg cat gac att gaa att act gtt att   1442
Asp Met Arg Gln Phe Ala Glu Met His Asp Ile Glu Ile Thr Val Ile
                465                 470                 475
 
gat aat gat act aga ttg cca gct ttt aaa gat gct ttg aga tgg aat   1490
Asp Asn Asp Thr Arg Leu Pro Ala Phe Lys Asp Ala Leu Arg Trp Asn
            480                 485                 490
 
gaa gtt tat tat gga ttt aga aga actagtcgat gcct                   1528
Glu Val Tyr Tyr Gly Phe Arg Arg
        495                 500
 

<210> 212
<211> 500
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in P. pastoris

<400> 212
Met Thr Ile Phe Asp Asn Tyr Glu Val Trp Phe Val Ile Gly Ser Gln
 1               5                  10                  15      
His Leu Tyr Gly Pro Glu Thr Leu Arg Gln Val Thr Gln His Ala Glu
            20                  25                  30          
His Val Val Asn Ala Leu Asn Thr Glu Ala Lys Leu Pro Cys Lys Leu
        35                  40                  45              
Val Leu Lys Pro Leu Gly Thr Thr Pro Asp Glu Ile Thr Ala Ile Cys
    50                  55                  60                  
Arg Asp Ala Asn Tyr Asp Asp Pro Cys Ala Gly Leu Val Val Trp Leu
65                  70                  75                  80  
His Thr Phe Ser Pro Ala Lys Met Trp Ile Asn Gly Leu Thr Met Leu
                85                  90                  95      
Asn Lys Pro Leu Leu Gln Phe His Thr Gln Phe Asn Ala Ala Leu Pro
            100                 105                 110         
Trp Asp Ser Ile Asp Met Asp Phe Met Asn Leu Asn Gln Thr Ala His
        115                 120                 125             
Gly Gly Arg Glu Phe Gly Phe Ile Gly Ala Arg Met Arg Gln Gln His
    130                 135                 140                 
Ala Val Val Thr Gly His Trp Gln Asp Lys Gln Ala His Glu Arg Ile
145                 150                 155                 160 
Gly Ser Trp Met Arg Gln Ala Val Ser Lys Gln Asp Thr Arg His Leu
                165                 170                 175     
Lys Val Cys Arg Phe Gly Asp Asn Met Arg Glu Val Ala Val Thr Asp
            180                 185                 190         
Gly Asp Lys Val Ala Ala Gln Ile Lys Phe Gly Phe Ser Val Asn Thr
        195                 200                 205             
Trp Ala Val Gly Asp Leu Val Gln Val Val Asn Ser Ile Ser Asp Gly
    210                 215                 220                 
Asp Val Asn Ala Leu Val Asp Glu Tyr Glu Ser Cys Tyr Thr Met Thr
225                 230                 235                 240 
Pro Ala Thr Gln Ile His Gly Glu Lys Arg Gln Asn Val Leu Glu Ala
                245                 250                 255     
Ala Arg Ile Glu Leu Gly Met Lys Arg Phe Leu Glu Gln Gly Gly Phe
            260                 265                 270         
His Ala Phe Thr Thr Thr Phe Glu Asp Leu His Gly Leu Lys Gln Leu
        275                 280                 285             
Pro Gly Leu Ala Val Gln Arg Leu Met Gln Gln Gly Tyr Gly Phe Ala
    290                 295                 300                 
Gly Glu Gly Asp Trp Lys Thr Ala Ala Leu Leu Arg Ile Met Lys Val
305                 310                 315                 320 
Met Ser Thr Gly Leu Gln Gly Gly Thr Ser Phe Met Glu Asp Tyr Thr
                325                 330                 335     
Tyr His Phe Glu Lys Gly Asn Asp Leu Val Leu Gly Ser His Met Leu
            340                 345                 350         
Glu Val Cys Pro Ser Ile Ala Val Glu Glu Lys Pro Ile Leu Asp Val
        355                 360                 365             
Gln His Leu Gly Ile Gly Gly Lys Asp Asp Pro Ala Arg Leu Ile Phe
    370                 375                 380                 
Asn Thr Gln Thr Gly Pro Ala Ile Val Ala Ser Leu Ile Asp Leu Gly
385                 390                 395                 400 
Asp Arg Tyr Arg Leu Leu Val Asn Cys Ile Asp Thr Val Lys Thr Pro
                405                 410                 415     
His Ser Leu Pro Lys Leu Pro Val Ala Asn Ala Leu Trp Lys Ala Gln
            420                 425                 430         
Pro Asp Leu Pro Thr Ala Ser Glu Ala Trp Ile Leu Ala Gly Gly Ala
        435                 440                 445             
His His Thr Val Phe Ser His Ala Leu Asn Leu Asn Asp Met Arg Gln
    450                 455                 460                 
Phe Ala Glu Met His Asp Ile Glu Ile Thr Val Ile Asp Asn Asp Thr
465                 470                 475                 480 
Arg Leu Pro Ala Phe Lys Asp Ala Leu Arg Trp Asn Glu Val Tyr Tyr
                485                 490                 495     
Gly Phe Arg Arg
            500 


<210> 213
<211> 1500
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in K. lactis

<220> 
<221> CDS            
<222> (1)...(1500)

<400> 213
atg act att ttc gat aat tat gaa gtt tgg ttc gtt att ggt tct caa   48
Met Thr Ile Phe Asp Asn Tyr Glu Val Trp Phe Val Ile Gly Ser Gln
 1               5                   10                  15
 
cat ttg tat ggt cca gaa act tta aga caa gtt act caa cat gct gaa   96
His Leu Tyr Gly Pro Glu Thr Leu Arg Gln Val Thr Gln His Ala Glu
             20                  25                  30
 
cac gtc gtt aat gct tta aat act gaa gcg aaa ttg cca tgt aaa ttg   144
His Val Val Asn Ala Leu Asn Thr Glu Ala Lys Leu Pro Cys Lys Leu
         35                  40                  45
 
gtt tta aag cca ttg gga act act cca gat gaa att act gct att tgt   192
Val Leu Lys Pro Leu Gly Thr Thr Pro Asp Glu Ile Thr Ala Ile Cys
     50                  55                  60
 
aga gat gct aat tat gat gat cca tgt gct ggt ttg gtt gtt tgg tta   240
Arg Asp Ala Asn Tyr Asp Asp Pro Cys Ala Gly Leu Val Val Trp Leu
 65                  70                  75                  80
 
cat act ttc tct cct gct aaa atg tgg att aat ggt ttg act atg tta   288
His Thr Phe Ser Pro Ala Lys Met Trp Ile Asn Gly Leu Thr Met Leu
                 85                  90                  95
 
aac aaa cca ttg ttg caa ttt cat act caa ttc aat gct gct ttg cca   336
Asn Lys Pro Leu Leu Gln Phe His Thr Gln Phe Asn Ala Ala Leu Pro
            100                 105                 110
 
tgg gat tct att gat atg gat ttc atg aat tta aac caa act gct cac   384
Trp Asp Ser Ile Asp Met Asp Phe Met Asn Leu Asn Gln Thr Ala His
        115                 120                 125
 
ggt ggt aga gag ttc ggt ttc att ggt gct aga atg aga caa caa cat   432
Gly Gly Arg Glu Phe Gly Phe Ile Gly Ala Arg Met Arg Gln Gln His
    130                 135                 140
 
gca gtg gtt act ggt cat tgg caa gat aag caa gct cat gaa aga att   480
Ala Val Val Thr Gly His Trp Gln Asp Lys Gln Ala His Glu Arg Ile
145                 150                 155                 160
 
ggt tct tgg atg aga caa gct gtt tct aaa caa gat act aga cat tta   528
Gly Ser Trp Met Arg Gln Ala Val Ser Lys Gln Asp Thr Arg His Leu
                165                 170                 175
 
aaa gtt tgt aga ttc ggt gat aat atg aga gaa gtt gct gtt act gat   576
Lys Val Cys Arg Phe Gly Asp Asn Met Arg Glu Val Ala Val Thr Asp
            180                 185                 190
 
ggt gat aag gtt gct gct caa att aaa ttc ggt ttc tct gtt aat act   624
Gly Asp Lys Val Ala Ala Gln Ile Lys Phe Gly Phe Ser Val Asn Thr
        195                 200                 205
 
tgg gct gtt ggt gat ttg gtt caa gtt gtt aat tct att tct gat ggg   672
Trp Ala Val Gly Asp Leu Val Gln Val Val Asn Ser Ile Ser Asp Gly
    210                 215                 220
 
gat gtg aat gct ttg gtc gac gaa tac gaa tct tgt tat act atg act   720
Asp Val Asn Ala Leu Val Asp Glu Tyr Glu Ser Cys Tyr Thr Met Thr
225                 230                 235                 240
 
cca gct act caa att cat ggt gag aag aga caa aat gtt ttg gaa gct   768
Pro Ala Thr Gln Ile His Gly Glu Lys Arg Gln Asn Val Leu Glu Ala
                245                 250                 255
 
gct aga att gaa ttg ggc atg aag aga ttc ttg gaa caa ggt ggt ttc   816
Ala Arg Ile Glu Leu Gly Met Lys Arg Phe Leu Glu Gln Gly Gly Phe
            260                 265                 270
 
cac gct ttc act act act ttc gaa gat ttg cat ggt tta aaa caa ttg   864
His Ala Phe Thr Thr Thr Phe Glu Asp Leu His Gly Leu Lys Gln Leu
        275                 280                 285
 
cca ggt ttg gct gtg caa aga ttg atg caa caa ggt tat ggt ttc gct   912
Pro Gly Leu Ala Val Gln Arg Leu Met Gln Gln Gly Tyr Gly Phe Ala
    290                 295                 300
 
ggt gaa ggt gat tgg aaa act gct gcc tta ctg aga att atg aaa gtt   960
Gly Glu Gly Asp Trp Lys Thr Ala Ala Leu Leu Arg Ile Met Lys Val
305                 310                 315                 320
 
atg tct act ggt ttg caa gga ggc aca tct ttc atg gaa gat tat act   1008
Met Ser Thr Gly Leu Gln Gly Gly Thr Ser Phe Met Glu Asp Tyr Thr
                325                 330                 335
 
tat cac ttc gaa aaa ggt aat gat ttg gtg ttg ggt tct cac atg ttg   1056
Tyr His Phe Glu Lys Gly Asn Asp Leu Val Leu Gly Ser His Met Leu
            340                 345                 350
 
gaa gtt tgt cca tct att gct gtt gaa gaa aaa cca att ttg gat gtt   1104
Glu Val Cys Pro Ser Ile Ala Val Glu Glu Lys Pro Ile Leu Asp Val
        355                 360                 365
 
caa cat ttg gga att ggt gga aaa gat gat cca gct aga ttg att ttc   1152
Gln His Leu Gly Ile Gly Gly Lys Asp Asp Pro Ala Arg Leu Ile Phe
    370                 375                 380
 
aat act caa act ggt ccg gct att gtg gct tct tta att gat ttg ggt   1200
Asn Thr Gln Thr Gly Pro Ala Ile Val Ala Ser Leu Ile Asp Leu Gly
385                 390                 395                 400
 
gat aga tat aga ttg ttg gtt aat tgt att gat act gtt aaa act cca   1248
Asp Arg Tyr Arg Leu Leu Val Asn Cys Ile Asp Thr Val Lys Thr Pro
                405                 410                 415
 
cat tct tta cca aaa ttg cct gtt gct aat gct ttg tgg aaa gct caa   1296
His Ser Leu Pro Lys Leu Pro Val Ala Asn Ala Leu Trp Lys Ala Gln
            420                 425                 430
 
cca gat ttg cca act gct tct gag gct tgg att ttg gct ggc ggg gct   1344
Pro Asp Leu Pro Thr Ala Ser Glu Ala Trp Ile Leu Ala Gly Gly Ala
        435                 440                 445
 
cat cat act gtt ttc tct cac gca ctg aat tta aac gat atg aga caa   1392
His His Thr Val Phe Ser His Ala Leu Asn Leu Asn Asp Met Arg Gln
    450                 455                 460
 
ttc gct gaa atg cat gac atc gaa att act gtt att gat aat gat act   1440
Phe Ala Glu Met His Asp Ile Glu Ile Thr Val Ile Asp Asn Asp Thr
465                 470                 475                 480
 
aga tta cct gcg ttc aag gac gcg ctt aga tgg aat gaa gtt tat tat   1488
Arg Leu Pro Ala Phe Lys Asp Ala Leu Arg Trp Asn Glu Val Tyr Tyr
                485                 490                 495
 
ggt ttc agg agg                                                   1500
Gly Phe Arg Arg
            500
 

<210> 214
<211> 500
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in K. lactis

<400> 214
Met Thr Ile Phe Asp Asn Tyr Glu Val Trp Phe Val Ile Gly Ser Gln
 1               5                  10                  15      
His Leu Tyr Gly Pro Glu Thr Leu Arg Gln Val Thr Gln His Ala Glu
            20                  25                  30          
His Val Val Asn Ala Leu Asn Thr Glu Ala Lys Leu Pro Cys Lys Leu
        35                  40                  45              
Val Leu Lys Pro Leu Gly Thr Thr Pro Asp Glu Ile Thr Ala Ile Cys
    50                  55                  60                  
Arg Asp Ala Asn Tyr Asp Asp Pro Cys Ala Gly Leu Val Val Trp Leu
65                  70                  75                  80  
His Thr Phe Ser Pro Ala Lys Met Trp Ile Asn Gly Leu Thr Met Leu
                85                  90                  95      
Asn Lys Pro Leu Leu Gln Phe His Thr Gln Phe Asn Ala Ala Leu Pro
            100                 105                 110         
Trp Asp Ser Ile Asp Met Asp Phe Met Asn Leu Asn Gln Thr Ala His
        115                 120                 125             
Gly Gly Arg Glu Phe Gly Phe Ile Gly Ala Arg Met Arg Gln Gln His
    130                 135                 140                 
Ala Val Val Thr Gly His Trp Gln Asp Lys Gln Ala His Glu Arg Ile
145                 150                 155                 160 
Gly Ser Trp Met Arg Gln Ala Val Ser Lys Gln Asp Thr Arg His Leu
                165                 170                 175     
Lys Val Cys Arg Phe Gly Asp Asn Met Arg Glu Val Ala Val Thr Asp
            180                 185                 190         
Gly Asp Lys Val Ala Ala Gln Ile Lys Phe Gly Phe Ser Val Asn Thr
        195                 200                 205             
Trp Ala Val Gly Asp Leu Val Gln Val Val Asn Ser Ile Ser Asp Gly
    210                 215                 220                 
Asp Val Asn Ala Leu Val Asp Glu Tyr Glu Ser Cys Tyr Thr Met Thr
225                 230                 235                 240 
Pro Ala Thr Gln Ile His Gly Glu Lys Arg Gln Asn Val Leu Glu Ala
                245                 250                 255     
Ala Arg Ile Glu Leu Gly Met Lys Arg Phe Leu Glu Gln Gly Gly Phe
            260                 265                 270         
His Ala Phe Thr Thr Thr Phe Glu Asp Leu His Gly Leu Lys Gln Leu
        275                 280                 285             
Pro Gly Leu Ala Val Gln Arg Leu Met Gln Gln Gly Tyr Gly Phe Ala
    290                 295                 300                 
Gly Glu Gly Asp Trp Lys Thr Ala Ala Leu Leu Arg Ile Met Lys Val
305                 310                 315                 320 
Met Ser Thr Gly Leu Gln Gly Gly Thr Ser Phe Met Glu Asp Tyr Thr
                325                 330                 335     
Tyr His Phe Glu Lys Gly Asn Asp Leu Val Leu Gly Ser His Met Leu
            340                 345                 350         
Glu Val Cys Pro Ser Ile Ala Val Glu Glu Lys Pro Ile Leu Asp Val
        355                 360                 365             
Gln His Leu Gly Ile Gly Gly Lys Asp Asp Pro Ala Arg Leu Ile Phe
    370                 375                 380                 
Asn Thr Gln Thr Gly Pro Ala Ile Val Ala Ser Leu Ile Asp Leu Gly
385                 390                 395                 400 
Asp Arg Tyr Arg Leu Leu Val Asn Cys Ile Asp Thr Val Lys Thr Pro
                405                 410                 415     
His Ser Leu Pro Lys Leu Pro Val Ala Asn Ala Leu Trp Lys Ala Gln
            420                 425                 430         
Pro Asp Leu Pro Thr Ala Ser Glu Ala Trp Ile Leu Ala Gly Gly Ala
        435                 440                 445             
His His Thr Val Phe Ser His Ala Leu Asn Leu Asn Asp Met Arg Gln
    450                 455                 460                 
Phe Ala Glu Met His Asp Ile Glu Ile Thr Val Ile Asp Asn Asp Thr
465                 470                 475                 480 
Arg Leu Pro Ala Phe Lys Asp Ala Leu Arg Trp Asn Glu Val Tyr Tyr
                485                 490                 495     
Gly Phe Arg Arg
            500 


<210> 215
<211> 1500
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in Z. mobilis

<220> 
<221> CDS            
<222> (1)...(1500)

<400> 215
atg acc att ttt gat aat tat gaa gtc tgg ttc gtg ata ggt tct cag   48
Met Thr Ile Phe Asp Asn Tyr Glu Val Trp Phe Val Ile Gly Ser Gln
 1               5                   10                  15
 
cat ttg tat ggt ccg gaa acc ttg cgt cag gtt acc cag cat gcc gaa   96
His Leu Tyr Gly Pro Glu Thr Leu Arg Gln Val Thr Gln His Ala Glu
             20                  25                  30
 
cat gtt gtt aat gcg ttg aat acc gag gcc aaa ttg ccg tgt aaa ttg   144
His Val Val Asn Ala Leu Asn Thr Glu Ala Lys Leu Pro Cys Lys Leu
         35                  40                  45
 
gtt ttg aaa ccg ttg ggt acg acc ccg gat gaa att acc gcc att tgt   192
Val Leu Lys Pro Leu Gly Thr Thr Pro Asp Glu Ile Thr Ala Ile Cys
     50                  55                  60
 
cgc gat gct aac tat gat gat ccg tgt gct ggt tta gtc gtc tgg tta   240
Arg Asp Ala Asn Tyr Asp Asp Pro Cys Ala Gly Leu Val Val Trp Leu
 65                  70                  75                  80
 
cat acc ttt tct ccg gcc aaa atg tgg att aat ggt ttg acc atg ttg   288
His Thr Phe Ser Pro Ala Lys Met Trp Ile Asn Gly Leu Thr Met Leu
                 85                  90                  95
 
aat aaa ccg tta ttg cag ttt cat acc cag ttt aat gct gct ctt ccg   336
Asn Lys Pro Leu Leu Gln Phe His Thr Gln Phe Asn Ala Ala Leu Pro
            100                 105                 110
 
tgg gac tcc att gat atg gat ttt atg aat ttg aat cag acc gca cat   384
Trp Asp Ser Ile Asp Met Asp Phe Met Asn Leu Asn Gln Thr Ala His
        115                 120                 125
 
ggt ggt aga gaa ttt ggt ttt att ggt gct aga atg cgt caa caa cat   432
Gly Gly Arg Glu Phe Gly Phe Ile Gly Ala Arg Met Arg Gln Gln His
    130                 135                 140
 
gca gta gta aca ggt cat tgg cag gat aaa cag gcc cat gaa cgt att   480
Ala Val Val Thr Gly His Trp Gln Asp Lys Gln Ala His Glu Arg Ile
145                 150                 155                 160
 
ggt tct tgg atg cga caa gcc gtt tct aaa cag gat acc cgc cac ctc   528
Gly Ser Trp Met Arg Gln Ala Val Ser Lys Gln Asp Thr Arg His Leu
                165                 170                 175
 
aaa gtt tgt aga ttc ggc gat aat atg aga gaa gtt gct gtt acc gat   576
Lys Val Cys Arg Phe Gly Asp Asn Met Arg Glu Val Ala Val Thr Asp
            180                 185                 190
 
ggt gat aaa gtt gca gcc cag att aaa ttt ggt ttt tct gtt aat acc   624
Gly Asp Lys Val Ala Ala Gln Ile Lys Phe Gly Phe Ser Val Asn Thr
        195                 200                 205
 
tgg gcc gtc gga gac ttg gtt cag gtt gtg aac tct att tct gat ggt   672
Trp Ala Val Gly Asp Leu Val Gln Val Val Asn Ser Ile Ser Asp Gly
    210                 215                 220
 
gac gtt aat gcc ctt gtt gat gaa tac gaa tct tgt tat acc atg acg   720
Asp Val Asn Ala Leu Val Asp Glu Tyr Glu Ser Cys Tyr Thr Met Thr
225                 230                 235                 240
 
ccc gca aca cag att cat ggc gag aaa cgt cag aat gtt ttg gaa gct   768
Pro Ala Thr Gln Ile His Gly Glu Lys Arg Gln Asn Val Leu Glu Ala
                245                 250                 255
 
gct cgt att gaa ttg ggt atg aag cgg ttc ctt gaa cag ggt ggt ttt   816
Ala Arg Ile Glu Leu Gly Met Lys Arg Phe Leu Glu Gln Gly Gly Phe
            260                 265                 270
 
cat gcc ttc acc acc act ttc gaa gat ttg cat ggt ttg aaa cag ttg   864
His Ala Phe Thr Thr Thr Phe Glu Asp Leu His Gly Leu Lys Gln Leu
        275                 280                 285
 
cca ggt ttg gct gtc cag cgt ctt atg cag cag ggt tat ggt ttt gct   912
Pro Gly Leu Ala Val Gln Arg Leu Met Gln Gln Gly Tyr Gly Phe Ala
    290                 295                 300
 
ggt gag ggt gac tgg aaa aca gcc gca ctg ttg cgc att atg aaa gtt   960
Gly Glu Gly Asp Trp Lys Thr Ala Ala Leu Leu Arg Ile Met Lys Val
305                 310                 315                 320
 
atg tct acc ggt ttg caa gga ggg act agc ttc atg gag gac tat acg   1008
Met Ser Thr Gly Leu Gln Gly Gly Thr Ser Phe Met Glu Asp Tyr Thr
                325                 330                 335
 
tac cac ttt gaa aaa ggt aat gat ttg gtt ttg ggt tct cac atg ctt   1056
Tyr His Phe Glu Lys Gly Asn Asp Leu Val Leu Gly Ser His Met Leu
            340                 345                 350
 
gaa gtt tgt ccg tct att gca gtc gaa gaa aaa ccg att ttg gat gtt   1104
Glu Val Cys Pro Ser Ile Ala Val Glu Glu Lys Pro Ile Leu Asp Val
        355                 360                 365
 
caa cat ttg ggc ata ggt ggt aaa gat gat cct gct cgc ttg att ttt   1152
Gln His Leu Gly Ile Gly Gly Lys Asp Asp Pro Ala Arg Leu Ile Phe
    370                 375                 380
 
aat acc cag acc ggg cca gcc ata gtt gcc tct ttg att gat ttg ggt   1200
Asn Thr Gln Thr Gly Pro Ala Ile Val Ala Ser Leu Ile Asp Leu Gly
385                 390                 395                 400
 
gat cgt tat cgc ctt tta gtc aac tgc att gat acc gtt aaa acc cct   1248
Asp Arg Tyr Arg Leu Leu Val Asn Cys Ile Asp Thr Val Lys Thr Pro
                405                 410                 415
 
cac agt ttg cct aaa ttg cca gtt gct aat gct ctt tgg aaa gcc caa   1296
His Ser Leu Pro Lys Leu Pro Val Ala Asn Ala Leu Trp Lys Ala Gln
            420                 425                 430
 
ccc gat ttg ccg acc gcg tct gaa gcg tgg att ctt gca ggt ggt gct   1344
Pro Asp Leu Pro Thr Ala Ser Glu Ala Trp Ile Leu Ala Gly Gly Ala
        435                 440                 445
 
cac cat acg gtc ttt tct cat gca ttg aac ttg aat gat atg cgc caa   1392
His His Thr Val Phe Ser His Ala Leu Asn Leu Asn Asp Met Arg Gln
    450                 455                 460
 
ttc gca gag atg cat gac atc gag atc acg gtg ata gat aat gat acg   1440
Phe Ala Glu Met His Asp Ile Glu Ile Thr Val Ile Asp Asn Asp Thr
465                 470                 475                 480
 
cgt ttg cct gcc ttc aaa gat gct ctt cgt tgg aat gaa gtt tat tat   1488
Arg Leu Pro Ala Phe Lys Asp Ala Leu Arg Trp Asn Glu Val Tyr Tyr
                485                 490                 495
 
ggt ttt cgt cgt                                                   1500
Gly Phe Arg Arg
            500
 

<210> 216
<211> 500
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in Z. mobilis

<400> 216
Met Thr Ile Phe Asp Asn Tyr Glu Val Trp Phe Val Ile Gly Ser Gln
 1               5                  10                  15      
His Leu Tyr Gly Pro Glu Thr Leu Arg Gln Val Thr Gln His Ala Glu
            20                  25                  30          
His Val Val Asn Ala Leu Asn Thr Glu Ala Lys Leu Pro Cys Lys Leu
        35                  40                  45              
Val Leu Lys Pro Leu Gly Thr Thr Pro Asp Glu Ile Thr Ala Ile Cys
    50                  55                  60                  
Arg Asp Ala Asn Tyr Asp Asp Pro Cys Ala Gly Leu Val Val Trp Leu
65                  70                  75                  80  
His Thr Phe Ser Pro Ala Lys Met Trp Ile Asn Gly Leu Thr Met Leu
                85                  90                  95      
Asn Lys Pro Leu Leu Gln Phe His Thr Gln Phe Asn Ala Ala Leu Pro
            100                 105                 110         
Trp Asp Ser Ile Asp Met Asp Phe Met Asn Leu Asn Gln Thr Ala His
        115                 120                 125             
Gly Gly Arg Glu Phe Gly Phe Ile Gly Ala Arg Met Arg Gln Gln His
    130                 135                 140                 
Ala Val Val Thr Gly His Trp Gln Asp Lys Gln Ala His Glu Arg Ile
145                 150                 155                 160 
Gly Ser Trp Met Arg Gln Ala Val Ser Lys Gln Asp Thr Arg His Leu
                165                 170                 175     
Lys Val Cys Arg Phe Gly Asp Asn Met Arg Glu Val Ala Val Thr Asp
            180                 185                 190         
Gly Asp Lys Val Ala Ala Gln Ile Lys Phe Gly Phe Ser Val Asn Thr
        195                 200                 205             
Trp Ala Val Gly Asp Leu Val Gln Val Val Asn Ser Ile Ser Asp Gly
    210                 215                 220                 
Asp Val Asn Ala Leu Val Asp Glu Tyr Glu Ser Cys Tyr Thr Met Thr
225                 230                 235                 240 
Pro Ala Thr Gln Ile His Gly Glu Lys Arg Gln Asn Val Leu Glu Ala
                245                 250                 255     
Ala Arg Ile Glu Leu Gly Met Lys Arg Phe Leu Glu Gln Gly Gly Phe
            260                 265                 270         
His Ala Phe Thr Thr Thr Phe Glu Asp Leu His Gly Leu Lys Gln Leu
        275                 280                 285             
Pro Gly Leu Ala Val Gln Arg Leu Met Gln Gln Gly Tyr Gly Phe Ala
    290                 295                 300                 
Gly Glu Gly Asp Trp Lys Thr Ala Ala Leu Leu Arg Ile Met Lys Val
305                 310                 315                 320 
Met Ser Thr Gly Leu Gln Gly Gly Thr Ser Phe Met Glu Asp Tyr Thr
                325                 330                 335     
Tyr His Phe Glu Lys Gly Asn Asp Leu Val Leu Gly Ser His Met Leu
            340                 345                 350         
Glu Val Cys Pro Ser Ile Ala Val Glu Glu Lys Pro Ile Leu Asp Val
        355                 360                 365             
Gln His Leu Gly Ile Gly Gly Lys Asp Asp Pro Ala Arg Leu Ile Phe
    370                 375                 380                 
Asn Thr Gln Thr Gly Pro Ala Ile Val Ala Ser Leu Ile Asp Leu Gly
385                 390                 395                 400 
Asp Arg Tyr Arg Leu Leu Val Asn Cys Ile Asp Thr Val Lys Thr Pro
                405                 410                 415     
His Ser Leu Pro Lys Leu Pro Val Ala Asn Ala Leu Trp Lys Ala Gln
            420                 425                 430         
Pro Asp Leu Pro Thr Ala Ser Glu Ala Trp Ile Leu Ala Gly Gly Ala
        435                 440                 445             
His His Thr Val Phe Ser His Ala Leu Asn Leu Asn Asp Met Arg Gln
    450                 455                 460                 
Phe Ala Glu Met His Asp Ile Glu Ile Thr Val Ile Asp Asn Asp Thr
465                 470                 475                 480 
Arg Leu Pro Ala Phe Lys Asp Ala Leu Arg Trp Asn Glu Val Tyr Tyr
                485                 490                 495     
Gly Phe Arg Arg
            500 


<210> 217
<211> 1701
<212> DNA
<213> E. coli

<220> 
<221> CDS            
<222> (1)...(1701)

<400> 217
atg gcg att gca att ggc ctc gat ttt ggc agt gat tct gtg cga gct   48
Met Ala Ile Ala Ile Gly Leu Asp Phe Gly Ser Asp Ser Val Arg Ala
 1               5                   10                  15
 
ttg gcg gtg gac tgc gcc agc ggt gaa gag atc gcc acc agc gta gag   96
Leu Ala Val Asp Cys Ala Ser Gly Glu Glu Ile Ala Thr Ser Val Glu
             20                  25                  30
 
tgg tat ccc cgt tgg caa aaa ggg caa ttt tgt gat gcc ccg aat aac   144
Trp Tyr Pro Arg Trp Gln Lys Gly Gln Phe Cys Asp Ala Pro Asn Asn
         35                  40                  45
 
cag ttc cgt cat cat ccg cgt gac tac att gag tca atg gaa gcg gca   192
Gln Phe Arg His His Pro Arg Asp Tyr Ile Glu Ser Met Glu Ala Ala
     50                  55                  60
 
ctg aaa acc gtg ctt gca gag ctt agc gtc gaa cag cgc gca gct gtg   240
Leu Lys Thr Val Leu Ala Glu Leu Ser Val Glu Gln Arg Ala Ala Val
 65                  70                  75                  80
 
gtc ggg att ggc gtt gac agt acc ggc tcg acg ccc gca ccg att gat   288
Val Gly Ile Gly Val Asp Ser Thr Gly Ser Thr Pro Ala Pro Ile Asp
                 85                  90                  95
 
gcc gac ggt aac gtg ctg gcg ctg cgc ccg gag ttt gcc gaa aac ccg   336
Ala Asp Gly Asn Val Leu Ala Leu Arg Pro Glu Phe Ala Glu Asn Pro
            100                 105                 110
 
aac gcg atg ttc gta ttg tgg aaa gac cac act gcg gtt gaa aga agc   384
Asn Ala Met Phe Val Leu Trp Lys Asp His Thr Ala Val Glu Arg Ser
        115                 120                 125
 
gaa gag att acc cgt ttg tgc cac gcg ccg ggc aat gtt gac tac tcc   432
Glu Glu Ile Thr Arg Leu Cys His Ala Pro Gly Asn Val Asp Tyr Ser
    130                 135                 140
 
cgc tat att ggc ggt att tat tcc agc gaa tgg ttc tgg gca aaa atc   480
Arg Tyr Ile Gly Gly Ile Tyr Ser Ser Glu Trp Phe Trp Ala Lys Ile
145                 150                 155                 160
 
ctg cat gtg act cgc cag gac agc gcc gtg gcg caa tct gcc gca tcg   528
Leu His Val Thr Arg Gln Asp Ser Ala Val Ala Gln Ser Ala Ala Ser
                165                 170                 175
 
tgg att gag ctg tgc gac tgg gtg cca gct ctg ctt tcc ggt acc acc   576
Trp Ile Glu Leu Cys Asp Trp Val Pro Ala Leu Leu Ser Gly Thr Thr
            180                 185                 190
 
cgc ccg cag gat att cgt cgc gga cgt tgc agc gcc ggg cat aaa tct   624
Arg Pro Gln Asp Ile Arg Arg Gly Arg Cys Ser Ala Gly His Lys Ser
        195                 200                 205
 
ctg tgg cac gaa agc tgg ggc ggc ttg ccg cca gcc agt ttc ttt gat   672
Leu Trp His Glu Ser Trp Gly Gly Leu Pro Pro Ala Ser Phe Phe Asp
    210                 215                 220
 
gag ctg gac ccg atc ctc aat cgc cat ttg cct tcc ccg ctg ttc act   720
Glu Leu Asp Pro Ile Leu Asn Arg His Leu Pro Ser Pro Leu Phe Thr
225                 230                 235                 240
 
gac acc tgg act gcc gat att ccg gtg ggc acc tta tgc ccg gaa tgg   768
Asp Thr Trp Thr Ala Asp Ile Pro Val Gly Thr Leu Cys Pro Glu Trp
                245                 250                 255
 
gcg cag cgt ctc ggc ctg cct gaa agc gtg gtg att tcc ggc ggc gcg   816
Ala Gln Arg Leu Gly Leu Pro Glu Ser Val Val Ile Ser Gly Gly Ala
            260                 265                 270
 
ttt gac tgc cat atg ggc gca gtt ggc gca ggc gca cag cct aac gca   864
Phe Asp Cys His Met Gly Ala Val Gly Ala Gly Ala Gln Pro Asn Ala
        275                 280                 285
 
ctg gta aaa gtt atc ggt act tcc acc tgc gac att ctg att gcc gac   912
Leu Val Lys Val Ile Gly Thr Ser Thr Cys Asp Ile Leu Ile Ala Asp
    290                 295                 300
 
aaa cag agc gtt ggc gag cgg gca gtt aaa ggt att tgc ggt cag gtt   960
Lys Gln Ser Val Gly Glu Arg Ala Val Lys Gly Ile Cys Gly Gln Val
305                 310                 315                 320
 
gat ggc agc gtg gtg cct gga ttt atc ggt ctg gaa gca ggc caa tcg   1008
Asp Gly Ser Val Val Pro Gly Phe Ile Gly Leu Glu Ala Gly Gln Ser
                325                 330                 335
 
gcg ttt ggt gat atc tac gcc tgg ttc ggt cgc gta ctc agc tgg ccg   1056
Ala Phe Gly Asp Ile Tyr Ala Trp Phe Gly Arg Val Leu Ser Trp Pro
            340                 345                 350
 
ctg gaa cag ctt gcc gcc cag cat ccg gaa ctg aaa gcg caa atc aac   1104
Leu Glu Gln Leu Ala Ala Gln His Pro Glu Leu Lys Ala Gln Ile Asn
        355                 360                 365
 
gcc agc cag aaa caa ctg ctt ccg gcg ctg acc gaa gca tgg gcc aaa   1152
Ala Ser Gln Lys Gln Leu Leu Pro Ala Leu Thr Glu Ala Trp Ala Lys
    370                 375                 380
 
aat ccg tct ctg gat cac ctg ccg gtg gtg ctc gac tgg ttt aac ggt   1200
Asn Pro Ser Leu Asp His Leu Pro Val Val Leu Asp Trp Phe Asn Gly
385                 390                 395                 400
 
cgt cgc tcg cca aac gct aac caa cgc ctg aaa ggg gtg att acc gat   1248
Arg Arg Ser Pro Asn Ala Asn Gln Arg Leu Lys Gly Val Ile Thr Asp
                405                 410                 415
 
ctt aac ctc gct acc gac gct ccg ctg ctg ttc ggc ggt ttg att gct   1296
Leu Asn Leu Ala Thr Asp Ala Pro Leu Leu Phe Gly Gly Leu Ile Ala
            420                 425                 430
 
gcc acc gcc ttt ggc gca cgc gca atc atg gag tgc ttt acc gat cag   1344
Ala Thr Ala Phe Gly Ala Arg Ala Ile Met Glu Cys Phe Thr Asp Gln
        435                 440                 445
 
ggg atc gcc gtc aat aac gtg atg gcg ctg ggc ggc atc gcg cgg aaa   1392
Gly Ile Ala Val Asn Asn Val Met Ala Leu Gly Gly Ile Ala Arg Lys
    450                 455                 460
 
aac caa gtc att atg cag gcc tgc tgc gac gtg ctg aat cgc ccg ctg   1440
Asn Gln Val Ile Met Gln Ala Cys Cys Asp Val Leu Asn Arg Pro Leu
465                 470                 475                 480
 
caa att gtt gcc tct gac cag tgc tgt gcg ctc ggt gcg gcg att ttt   1488
Gln Ile Val Ala Ser Asp Gln Cys Cys Ala Leu Gly Ala Ala Ile Phe
                485                 490                 495
 
gct gcc gtc gcc gcg aaa gtg cac gca gac atc cca tca gcc cag caa   1536
Ala Ala Val Ala Ala Lys Val His Ala Asp Ile Pro Ser Ala Gln Gln
            500                 505                 510
 
aaa atg gcc agt gcg gta gag aaa acc ctg caa ccg cgc agc gaa cag   1584
Lys Met Ala Ser Ala Val Glu Lys Thr Leu Gln Pro Arg Ser Glu Gln
        515                 520                 525
 
gca caa cgc ttt gaa cag ctt tat cgc cgc tat cag caa tgg gcg atg   1632
Ala Gln Arg Phe Glu Gln Leu Tyr Arg Arg Tyr Gln Gln Trp Ala Met
    530                 535                 540
 
agc gcc gaa caa cac tat ctt cca act tcc gcc ccg gca cag gct gcc   1680
Ser Ala Glu Gln His Tyr Leu Pro Thr Ser Ala Pro Ala Gln Ala Ala
545                 550                 555                 560
 
cag gcc gtt gcg act cta taa                                       1701
Gln Ala Val Ala Thr Leu  *
                565
 

<210> 218
<211> 566
<212> PRT
<213> E. coli

<400> 218
Met Ala Ile Ala Ile Gly Leu Asp Phe Gly Ser Asp Ser Val Arg Ala
 1               5                  10                  15      
Leu Ala Val Asp Cys Ala Ser Gly Glu Glu Ile Ala Thr Ser Val Glu
            20                  25                  30          
Trp Tyr Pro Arg Trp Gln Lys Gly Gln Phe Cys Asp Ala Pro Asn Asn
        35                  40                  45              
Gln Phe Arg His His Pro Arg Asp Tyr Ile Glu Ser Met Glu Ala Ala
    50                  55                  60                  
Leu Lys Thr Val Leu Ala Glu Leu Ser Val Glu Gln Arg Ala Ala Val
65                  70                  75                  80  
Val Gly Ile Gly Val Asp Ser Thr Gly Ser Thr Pro Ala Pro Ile Asp
                85                  90                  95      
Ala Asp Gly Asn Val Leu Ala Leu Arg Pro Glu Phe Ala Glu Asn Pro
            100                 105                 110         
Asn Ala Met Phe Val Leu Trp Lys Asp His Thr Ala Val Glu Arg Ser
        115                 120                 125             
Glu Glu Ile Thr Arg Leu Cys His Ala Pro Gly Asn Val Asp Tyr Ser
    130                 135                 140                 
Arg Tyr Ile Gly Gly Ile Tyr Ser Ser Glu Trp Phe Trp Ala Lys Ile
145                 150                 155                 160 
Leu His Val Thr Arg Gln Asp Ser Ala Val Ala Gln Ser Ala Ala Ser
                165                 170                 175     
Trp Ile Glu Leu Cys Asp Trp Val Pro Ala Leu Leu Ser Gly Thr Thr
            180                 185                 190         
Arg Pro Gln Asp Ile Arg Arg Gly Arg Cys Ser Ala Gly His Lys Ser
        195                 200                 205             
Leu Trp His Glu Ser Trp Gly Gly Leu Pro Pro Ala Ser Phe Phe Asp
    210                 215                 220                 
Glu Leu Asp Pro Ile Leu Asn Arg His Leu Pro Ser Pro Leu Phe Thr
225                 230                 235                 240 
Asp Thr Trp Thr Ala Asp Ile Pro Val Gly Thr Leu Cys Pro Glu Trp
                245                 250                 255     
Ala Gln Arg Leu Gly Leu Pro Glu Ser Val Val Ile Ser Gly Gly Ala
            260                 265                 270         
Phe Asp Cys His Met Gly Ala Val Gly Ala Gly Ala Gln Pro Asn Ala
        275                 280                 285             
Leu Val Lys Val Ile Gly Thr Ser Thr Cys Asp Ile Leu Ile Ala Asp
    290                 295                 300                 
Lys Gln Ser Val Gly Glu Arg Ala Val Lys Gly Ile Cys Gly Gln Val
305                 310                 315                 320 
Asp Gly Ser Val Val Pro Gly Phe Ile Gly Leu Glu Ala Gly Gln Ser
                325                 330                 335     
Ala Phe Gly Asp Ile Tyr Ala Trp Phe Gly Arg Val Leu Ser Trp Pro
            340                 345                 350         
Leu Glu Gln Leu Ala Ala Gln His Pro Glu Leu Lys Ala Gln Ile Asn
        355                 360                 365             
Ala Ser Gln Lys Gln Leu Leu Pro Ala Leu Thr Glu Ala Trp Ala Lys
    370                 375                 380                 
Asn Pro Ser Leu Asp His Leu Pro Val Val Leu Asp Trp Phe Asn Gly
385                 390                 395                 400 
Arg Arg Ser Pro Asn Ala Asn Gln Arg Leu Lys Gly Val Ile Thr Asp
                405                 410                 415     
Leu Asn Leu Ala Thr Asp Ala Pro Leu Leu Phe Gly Gly Leu Ile Ala
            420                 425                 430         
Ala Thr Ala Phe Gly Ala Arg Ala Ile Met Glu Cys Phe Thr Asp Gln
        435                 440                 445             
Gly Ile Ala Val Asn Asn Val Met Ala Leu Gly Gly Ile Ala Arg Lys
    450                 455                 460                 
Asn Gln Val Ile Met Gln Ala Cys Cys Asp Val Leu Asn Arg Pro Leu
465                 470                 475                 480 
Gln Ile Val Ala Ser Asp Gln Cys Cys Ala Leu Gly Ala Ala Ile Phe
                485                 490                 495     
Ala Ala Val Ala Ala Lys Val His Ala Asp Ile Pro Ser Ala Gln Gln
            500                 505                 510         
Lys Met Ala Ser Ala Val Glu Lys Thr Leu Gln Pro Arg Ser Glu Gln
        515                 520                 525             
Ala Gln Arg Phe Glu Gln Leu Tyr Arg Arg Tyr Gln Gln Trp Ala Met
    530                 535                 540                 
Ser Ala Glu Gln His Tyr Leu Pro Thr Ser Ala Pro Ala Gln Ala Ala
545                 550                 555                 560 
Gln Ala Val Ala Thr Leu
                565     


<210> 219
<211> 1698
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in S. cerevisiae

<220> 
<221> CDS            
<222> (1)...(1698)

<400> 219
atg gct att gct att gga ttg gac ttt ggt tct gat tct gtt aga gct   48
Met Ala Ile Ala Ile Gly Leu Asp Phe Gly Ser Asp Ser Val Arg Ala
 1               5                   10                  15
 
ttg gct gtt gat tgt gct tct gga gaa gaa att gct act tct gtt gaa   96
Leu Ala Val Asp Cys Ala Ser Gly Glu Glu Ile Ala Thr Ser Val Glu
             20                  25                  30
 
tgg tat cct aga tgg caa aaa gga caa ttt tgt gat gct cca aat aat   144
Trp Tyr Pro Arg Trp Gln Lys Gly Gln Phe Cys Asp Ala Pro Asn Asn
         35                  40                  45
 
caa ttt aga cat cat cct aga gat tat att gaa tct atg gaa gct gct   192
Gln Phe Arg His His Pro Arg Asp Tyr Ile Glu Ser Met Glu Ala Ala
     50                  55                  60
 
tta aaa act gtt ttg gct gaa ttg tct gtt gaa caa aga gct gcc gtt   240
Leu Lys Thr Val Leu Ala Glu Leu Ser Val Glu Gln Arg Ala Ala Val
 65                  70                  75                  80
 
gtt gga att gga gtt gat tct act gga tct act cct gct cca att gat   288
Val Gly Ile Gly Val Asp Ser Thr Gly Ser Thr Pro Ala Pro Ile Asp
                 85                  90                  95
 
gct gat gga aat gtg ttg gct ttg aga cca gaa ttt gca gaa aat cct   336
Ala Asp Gly Asn Val Leu Ala Leu Arg Pro Glu Phe Ala Glu Asn Pro
            100                 105                 110
 
aac gct atg ttt gtt ttg tgg aaa gat cat act gct gtt gaa aga tct   384
Asn Ala Met Phe Val Leu Trp Lys Asp His Thr Ala Val Glu Arg Ser
        115                 120                 125
 
gaa gaa att act aga ttg tgt cat gct cca gga aat gtt gat tat tct   432
Glu Glu Ile Thr Arg Leu Cys His Ala Pro Gly Asn Val Asp Tyr Ser
    130                 135                 140
 
aga tat att gga gga att tat tct tct gaa tgg ttt tgg gct aaa att   480
Arg Tyr Ile Gly Gly Ile Tyr Ser Ser Glu Trp Phe Trp Ala Lys Ile
145                 150                 155                 160
 
ttg cat gtt act aga caa gat tct gct gtg gct caa tct gct gct tct   528
Leu His Val Thr Arg Gln Asp Ser Ala Val Ala Gln Ser Ala Ala Ser
                165                 170                 175
 
tgg att gaa ttg tgt gat tgg gtt cca gct tta ttg agt gga aca act   576
Trp Ile Glu Leu Cys Asp Trp Val Pro Ala Leu Leu Ser Gly Thr Thr
            180                 185                 190
 
aga cca caa gac att aga aga ggt aga tgt tct gct ggg cat aaa tca   624
Arg Pro Gln Asp Ile Arg Arg Gly Arg Cys Ser Ala Gly His Lys Ser
        195                 200                 205
 
ttg tgg cat gaa tct tgg ggt ggt ttg cct cct gct tca ttc ttt gat   672
Leu Trp His Glu Ser Trp Gly Gly Leu Pro Pro Ala Ser Phe Phe Asp
    210                 215                 220
 
gaa ttg gac cca att tta aat aga cat ttg cca tct cca ttg ttt act   720
Glu Leu Asp Pro Ile Leu Asn Arg His Leu Pro Ser Pro Leu Phe Thr
225                 230                 235                 240
 
gat act tgg act gct gat ata cca gtt ggt act tta tgt cca gaa tgg   768
Asp Thr Trp Thr Ala Asp Ile Pro Val Gly Thr Leu Cys Pro Glu Trp
                245                 250                 255
 
gct caa aga ttg gga ttg cca gaa tct gtt gtt att tca gga gga gct   816
Ala Gln Arg Leu Gly Leu Pro Glu Ser Val Val Ile Ser Gly Gly Ala
            260                 265                 270
 
ttt gat tgt cac atg gga gct gtt ggt gct ggc gct caa cct aat gca   864
Phe Asp Cys His Met Gly Ala Val Gly Ala Gly Ala Gln Pro Asn Ala
        275                 280                 285
 
ttg gtt aaa gtt att gga aca tct act tgt gac att ttg att gct gat   912
Leu Val Lys Val Ile Gly Thr Ser Thr Cys Asp Ile Leu Ile Ala Asp
    290                 295                 300
 
aaa caa tct gtt gga gaa aga gct gtt aaa gga att tgt gga caa gtt   960
Lys Gln Ser Val Gly Glu Arg Ala Val Lys Gly Ile Cys Gly Gln Val
305                 310                 315                 320
 
gat gga tct gtt gtt cca gga ttt att gga tta gaa gct gga caa tct   1008
Asp Gly Ser Val Val Pro Gly Phe Ile Gly Leu Glu Ala Gly Gln Ser
                325                 330                 335
 
gct ttt ggt gac att tat gct tgg ttt ggt aga gtt ttg tct tgg cca   1056
Ala Phe Gly Asp Ile Tyr Ala Trp Phe Gly Arg Val Leu Ser Trp Pro
            340                 345                 350
 
tta gaa caa ctc gct gct caa cat cca gaa tta aaa gct caa att aac   1104
Leu Glu Gln Leu Ala Ala Gln His Pro Glu Leu Lys Ala Gln Ile Asn
        355                 360                 365
 
gct tct caa aaa caa ttg ttg cca gct ttg act gaa gca tgg gct aaa   1152
Ala Ser Gln Lys Gln Leu Leu Pro Ala Leu Thr Glu Ala Trp Ala Lys
    370                 375                 380
 
aat cca tct tta gat cat ttg cca gtt gtt ttg gat tgg ttt aat ggt   1200
Asn Pro Ser Leu Asp His Leu Pro Val Val Leu Asp Trp Phe Asn Gly
385                 390                 395                 400
 
aga aga tct cca aat gca aat caa aga tta aaa gga gtt att act gat   1248
Arg Arg Ser Pro Asn Ala Asn Gln Arg Leu Lys Gly Val Ile Thr Asp
                405                 410                 415
 
tta aat ttg gct act gat gct cca ttg ttg ttt ggt gga ttg att gct   1296
Leu Asn Leu Ala Thr Asp Ala Pro Leu Leu Phe Gly Gly Leu Ile Ala
            420                 425                 430
 
gct act gct ttt ggt gct aga gct att atg gaa tgt ttt act gat cag   1344
Ala Thr Ala Phe Gly Ala Arg Ala Ile Met Glu Cys Phe Thr Asp Gln
        435                 440                 445
 
gga att gct gtt aat aat gtt atg gct ttg gga gga att gca agg aaa   1392
Gly Ile Ala Val Asn Asn Val Met Ala Leu Gly Gly Ile Ala Arg Lys
    450                 455                 460
 
aat caa gtt att atg cag gct tgt tgt gac gtt tta aat aga cca ttg   1440
Asn Gln Val Ile Met Gln Ala Cys Cys Asp Val Leu Asn Arg Pro Leu
465                 470                 475                 480
 
caa att gta gct tct gat caa tgt tgt gct tta gga gct gct att ttc   1488
Gln Ile Val Ala Ser Asp Gln Cys Cys Ala Leu Gly Ala Ala Ile Phe
                485                 490                 495
 
gct gcc gta gct gca aaa gtt cat gcc gat ata cca tct gct caa cag   1536
Ala Ala Val Ala Ala Lys Val His Ala Asp Ile Pro Ser Ala Gln Gln
            500                 505                 510
 
aaa atg gct tcg gct gta gaa aag aca ttg caa cct aga tct gaa caa   1584
Lys Met Ala Ser Ala Val Glu Lys Thr Leu Gln Pro Arg Ser Glu Gln
        515                 520                 525
 
gca caa aga ttt gag caa ttg tat aga aga tat caa caa tgg gct atg   1632
Ala Gln Arg Phe Glu Gln Leu Tyr Arg Arg Tyr Gln Gln Trp Ala Met
    530                 535                 540
 
agt gct gaa caa cat tat ttg cca act tct gca cct gct cag gct gca   1680
Ser Ala Glu Gln His Tyr Leu Pro Thr Ser Ala Pro Ala Gln Ala Ala
545                 550                 555                 560
 
caa gct gta gct act tta                                           1698
Gln Ala Val Ala Thr Leu
                565
 

<210> 220
<211> 566
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in S. cerevisiae

<400> 220
Met Ala Ile Ala Ile Gly Leu Asp Phe Gly Ser Asp Ser Val Arg Ala
 1               5                  10                  15      
Leu Ala Val Asp Cys Ala Ser Gly Glu Glu Ile Ala Thr Ser Val Glu
            20                  25                  30          
Trp Tyr Pro Arg Trp Gln Lys Gly Gln Phe Cys Asp Ala Pro Asn Asn
        35                  40                  45              
Gln Phe Arg His His Pro Arg Asp Tyr Ile Glu Ser Met Glu Ala Ala
    50                  55                  60                  
Leu Lys Thr Val Leu Ala Glu Leu Ser Val Glu Gln Arg Ala Ala Val
65                  70                  75                  80  
Val Gly Ile Gly Val Asp Ser Thr Gly Ser Thr Pro Ala Pro Ile Asp
                85                  90                  95      
Ala Asp Gly Asn Val Leu Ala Leu Arg Pro Glu Phe Ala Glu Asn Pro
            100                 105                 110         
Asn Ala Met Phe Val Leu Trp Lys Asp His Thr Ala Val Glu Arg Ser
        115                 120                 125             
Glu Glu Ile Thr Arg Leu Cys His Ala Pro Gly Asn Val Asp Tyr Ser
    130                 135                 140                 
Arg Tyr Ile Gly Gly Ile Tyr Ser Ser Glu Trp Phe Trp Ala Lys Ile
145                 150                 155                 160 
Leu His Val Thr Arg Gln Asp Ser Ala Val Ala Gln Ser Ala Ala Ser
                165                 170                 175     
Trp Ile Glu Leu Cys Asp Trp Val Pro Ala Leu Leu Ser Gly Thr Thr
            180                 185                 190         
Arg Pro Gln Asp Ile Arg Arg Gly Arg Cys Ser Ala Gly His Lys Ser
        195                 200                 205             
Leu Trp His Glu Ser Trp Gly Gly Leu Pro Pro Ala Ser Phe Phe Asp
    210                 215                 220                 
Glu Leu Asp Pro Ile Leu Asn Arg His Leu Pro Ser Pro Leu Phe Thr
225                 230                 235                 240 
Asp Thr Trp Thr Ala Asp Ile Pro Val Gly Thr Leu Cys Pro Glu Trp
                245                 250                 255     
Ala Gln Arg Leu Gly Leu Pro Glu Ser Val Val Ile Ser Gly Gly Ala
            260                 265                 270         
Phe Asp Cys His Met Gly Ala Val Gly Ala Gly Ala Gln Pro Asn Ala
        275                 280                 285             
Leu Val Lys Val Ile Gly Thr Ser Thr Cys Asp Ile Leu Ile Ala Asp
    290                 295                 300                 
Lys Gln Ser Val Gly Glu Arg Ala Val Lys Gly Ile Cys Gly Gln Val
305                 310                 315                 320 
Asp Gly Ser Val Val Pro Gly Phe Ile Gly Leu Glu Ala Gly Gln Ser
                325                 330                 335     
Ala Phe Gly Asp Ile Tyr Ala Trp Phe Gly Arg Val Leu Ser Trp Pro
            340                 345                 350         
Leu Glu Gln Leu Ala Ala Gln His Pro Glu Leu Lys Ala Gln Ile Asn
        355                 360                 365             
Ala Ser Gln Lys Gln Leu Leu Pro Ala Leu Thr Glu Ala Trp Ala Lys
    370                 375                 380                 
Asn Pro Ser Leu Asp His Leu Pro Val Val Leu Asp Trp Phe Asn Gly
385                 390                 395                 400 
Arg Arg Ser Pro Asn Ala Asn Gln Arg Leu Lys Gly Val Ile Thr Asp
                405                 410                 415     
Leu Asn Leu Ala Thr Asp Ala Pro Leu Leu Phe Gly Gly Leu Ile Ala
            420                 425                 430         
Ala Thr Ala Phe Gly Ala Arg Ala Ile Met Glu Cys Phe Thr Asp Gln
        435                 440                 445             
Gly Ile Ala Val Asn Asn Val Met Ala Leu Gly Gly Ile Ala Arg Lys
    450                 455                 460                 
Asn Gln Val Ile Met Gln Ala Cys Cys Asp Val Leu Asn Arg Pro Leu
465                 470                 475                 480 
Gln Ile Val Ala Ser Asp Gln Cys Cys Ala Leu Gly Ala Ala Ile Phe
                485                 490                 495     
Ala Ala Val Ala Ala Lys Val His Ala Asp Ile Pro Ser Ala Gln Gln
            500                 505                 510         
Lys Met Ala Ser Ala Val Glu Lys Thr Leu Gln Pro Arg Ser Glu Gln
        515                 520                 525             
Ala Gln Arg Phe Glu Gln Leu Tyr Arg Arg Tyr Gln Gln Trp Ala Met
    530                 535                 540                 
Ser Ala Glu Gln His Tyr Leu Pro Thr Ser Ala Pro Ala Gln Ala Ala
545                 550                 555                 560 
Gln Ala Val Ala Thr Leu
                565     


<210> 221
<211> 1726
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in S. cerevisiae

<220> 
<221> CDS            
<222> (15)...(1712)

<400> 221
gaatactcca tatg atg gct att gct att gga ttg gac ttt ggt tct gat   50
                Met Ala Ile Ala Ile Gly Leu Asp Phe Gly Ser Asp
                 1               5                   10
 
tct gtt aga gct ttg gct gtt gat tgt gct tct gga gaa gaa att gct   98
Ser Val Arg Ala Leu Ala Val Asp Cys Ala Ser Gly Glu Glu Ile Ala
         15                  20                  25
 
act tct gtt gaa tgg tat cct aga tgg caa aaa gga caa ttt tgt gat   146
Thr Ser Val Glu Trp Tyr Pro Arg Trp Gln Lys Gly Gln Phe Cys Asp
     30                  35                  40
 
gct cca aat aat caa ttt aga cat cat cct aga gat tat att gaa tct   194
Ala Pro Asn Asn Gln Phe Arg His His Pro Arg Asp Tyr Ile Glu Ser
 45                  50                  55                  60
 
atg gaa gct gct tta aaa act gtt ttg gct gaa ttg tct gtt gaa caa   242
Met Glu Ala Ala Leu Lys Thr Val Leu Ala Glu Leu Ser Val Glu Gln
                 65                  70                  75
 
aga gct gcc gtt gtt gga att gga gtt gat tct act gga tct act cct   290
Arg Ala Ala Val Val Gly Ile Gly Val Asp Ser Thr Gly Ser Thr Pro
             80                  85                  90
 
gct cca att gat gct gat gga aat gtg ttg gct ttg aga cca gaa ttt   338
Ala Pro Ile Asp Ala Asp Gly Asn Val Leu Ala Leu Arg Pro Glu Phe
         95                 100                 105
 
gca gaa aat cct aac gct atg ttt gtt ttg tgg aaa gat cat act gct   386
Ala Glu Asn Pro Asn Ala Met Phe Val Leu Trp Lys Asp His Thr Ala
    110                 115                 120
 
gtt gaa aga tct gaa gaa att act aga ttg tgt cat gct cca gga aat   434
Val Glu Arg Ser Glu Glu Ile Thr Arg Leu Cys His Ala Pro Gly Asn
125                 130                 135                 140
 
gtt gat tat tct aga tat att gga gga att tat tct tct gaa tgg ttt   482
Val Asp Tyr Ser Arg Tyr Ile Gly Gly Ile Tyr Ser Ser Glu Trp Phe
                145                 150                 155
 
tgg gct aaa att ttg cat gtt act aga caa gat tct gct gtg gct caa   530
Trp Ala Lys Ile Leu His Val Thr Arg Gln Asp Ser Ala Val Ala Gln
            160                 165                 170
 
tct gct gct tct tgg att gaa ttg tgt gat tgg gtt cca gct tta ttg   578
Ser Ala Ala Ser Trp Ile Glu Leu Cys Asp Trp Val Pro Ala Leu Leu
        175                 180                 185
 
agt gga aca act aga cca caa gac att aga aga ggt aga tgt tct gct   626
Ser Gly Thr Thr Arg Pro Gln Asp Ile Arg Arg Gly Arg Cys Ser Ala
    190                 195                 200
 
ggg cat aaa tca ttg tgg cat gaa tct tgg ggt ggt ttg cct cct gct   674
Gly His Lys Ser Leu Trp His Glu Ser Trp Gly Gly Leu Pro Pro Ala
205                 210                 215                 220
 
tca ttc ttt gat gaa ttg gac cca att tta aat aga cat ttg cca tct   722
Ser Phe Phe Asp Glu Leu Asp Pro Ile Leu Asn Arg His Leu Pro Ser
                225                 230                 235
 
cca ttg ttt act gat act tgg act gct gat ata cca gtt ggt act tta   770
Pro Leu Phe Thr Asp Thr Trp Thr Ala Asp Ile Pro Val Gly Thr Leu
            240                 245                 250
 
tgt cca gaa tgg gct caa aga ttg gga ttg cca gaa tct gtt gtt att   818
Cys Pro Glu Trp Ala Gln Arg Leu Gly Leu Pro Glu Ser Val Val Ile
        255                 260                 265
 
tca gga gga gct ttt gat tgt cac atg gga gct gtt ggt gct ggc gct   866
Ser Gly Gly Ala Phe Asp Cys His Met Gly Ala Val Gly Ala Gly Ala
    270                 275                 280
 
caa cct aat gca ttg gtt aaa gtt att gga aca tct act tgt gac att   914
Gln Pro Asn Ala Leu Val Lys Val Ile Gly Thr Ser Thr Cys Asp Ile
285                 290                 295                 300
 
ttg att gct gat aaa caa tct gtt gga gaa aga gct gtt aaa gga att   962
Leu Ile Ala Asp Lys Gln Ser Val Gly Glu Arg Ala Val Lys Gly Ile
                305                 310                 315
 
tgt gga caa gtt gat gga tct gtt gtt cca gga ttt att gga tta gaa   1010
Cys Gly Gln Val Asp Gly Ser Val Val Pro Gly Phe Ile Gly Leu Glu
            320                 325                 330
 
gct gga caa tct gct ttt ggt gac att tat gct tgg ttt ggt aga gtt   1058
Ala Gly Gln Ser Ala Phe Gly Asp Ile Tyr Ala Trp Phe Gly Arg Val
        335                 340                 345
 
ttg tct tgg cca tta gaa caa ctc gct gct caa cat cca gaa tta aaa   1106
Leu Ser Trp Pro Leu Glu Gln Leu Ala Ala Gln His Pro Glu Leu Lys
    350                 355                 360
 
gct caa att aac gct tct caa aaa caa ttg ttg cca gct ttg act gaa   1154
Ala Gln Ile Asn Ala Ser Gln Lys Gln Leu Leu Pro Ala Leu Thr Glu
365                 370                 375                 380
 
gca tgg gct aaa aat cca tct tta gat cat ttg cca gtt gtt ttg gat   1202
Ala Trp Ala Lys Asn Pro Ser Leu Asp His Leu Pro Val Val Leu Asp
                385                 390                 395
 
tgg ttt aat ggt aga aga tct cca aat gca aat caa aga tta aaa gga   1250
Trp Phe Asn Gly Arg Arg Ser Pro Asn Ala Asn Gln Arg Leu Lys Gly
            400                 405                 410
 
gtt att act gat tta aat ttg gct act gat gct cca ttg ttg ttt ggt   1298
Val Ile Thr Asp Leu Asn Leu Ala Thr Asp Ala Pro Leu Leu Phe Gly
        415                 420                 425
 
gga ttg att gct gct act gct ttt ggt gct aga gct att atg gaa tgt   1346
Gly Leu Ile Ala Ala Thr Ala Phe Gly Ala Arg Ala Ile Met Glu Cys
    430                 435                 440
 
ttt act gat cag gga att gct gtt aat aat gtt atg gct ttg gga gga   1394
Phe Thr Asp Gln Gly Ile Ala Val Asn Asn Val Met Ala Leu Gly Gly
445                 450                 455                 460
 
att gca agg aaa aat caa gtt att atg cag gct tgt tgt gac gtt tta   1442
Ile Ala Arg Lys Asn Gln Val Ile Met Gln Ala Cys Cys Asp Val Leu
                465                 470                 475
 
aat aga cca ttg caa att gta gct tct gat caa tgt tgt gct tta gga   1490
Asn Arg Pro Leu Gln Ile Val Ala Ser Asp Gln Cys Cys Ala Leu Gly
            480                 485                 490
 
gct gct att ttc gct gcc gta gct gca aaa gtt cat gcc gat ata cca   1538
Ala Ala Ile Phe Ala Ala Val Ala Ala Lys Val His Ala Asp Ile Pro
        495                 500                 505
 
tct gct caa cag aaa atg gct tcg gct gta gaa aag aca ttg caa cct   1586
Ser Ala Gln Gln Lys Met Ala Ser Ala Val Glu Lys Thr Leu Gln Pro
    510                 515                 520
 
aga tct gaa caa gca caa aga ttt gag caa ttg tat aga aga tat caa   1634
Arg Ser Glu Gln Ala Gln Arg Phe Glu Gln Leu Tyr Arg Arg Tyr Gln
525                 530                 535                 540
 
caa tgg gct atg agt gct gaa caa cat tat ttg cca act tct gca cct   1682
Gln Trp Ala Met Ser Ala Glu Gln His Tyr Leu Pro Thr Ser Ala Pro
                545                 550                 555
 
gct cag gct gca caa gct gta gct act tta actagtcgat gcct           1726
Ala Gln Ala Ala Gln Ala Val Ala Thr Leu
            560                 565
 

<210> 222
<211> 566
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in S. cerevisiae

<400> 222
Met Ala Ile Ala Ile Gly Leu Asp Phe Gly Ser Asp Ser Val Arg Ala
 1               5                  10                  15      
Leu Ala Val Asp Cys Ala Ser Gly Glu Glu Ile Ala Thr Ser Val Glu
            20                  25                  30          
Trp Tyr Pro Arg Trp Gln Lys Gly Gln Phe Cys Asp Ala Pro Asn Asn
        35                  40                  45              
Gln Phe Arg His His Pro Arg Asp Tyr Ile Glu Ser Met Glu Ala Ala
    50                  55                  60                  
Leu Lys Thr Val Leu Ala Glu Leu Ser Val Glu Gln Arg Ala Ala Val
65                  70                  75                  80  
Val Gly Ile Gly Val Asp Ser Thr Gly Ser Thr Pro Ala Pro Ile Asp
                85                  90                  95      
Ala Asp Gly Asn Val Leu Ala Leu Arg Pro Glu Phe Ala Glu Asn Pro
            100                 105                 110         
Asn Ala Met Phe Val Leu Trp Lys Asp His Thr Ala Val Glu Arg Ser
        115                 120                 125             
Glu Glu Ile Thr Arg Leu Cys His Ala Pro Gly Asn Val Asp Tyr Ser
    130                 135                 140                 
Arg Tyr Ile Gly Gly Ile Tyr Ser Ser Glu Trp Phe Trp Ala Lys Ile
145                 150                 155                 160 
Leu His Val Thr Arg Gln Asp Ser Ala Val Ala Gln Ser Ala Ala Ser
                165                 170                 175     
Trp Ile Glu Leu Cys Asp Trp Val Pro Ala Leu Leu Ser Gly Thr Thr
            180                 185                 190         
Arg Pro Gln Asp Ile Arg Arg Gly Arg Cys Ser Ala Gly His Lys Ser
        195                 200                 205             
Leu Trp His Glu Ser Trp Gly Gly Leu Pro Pro Ala Ser Phe Phe Asp
    210                 215                 220                 
Glu Leu Asp Pro Ile Leu Asn Arg His Leu Pro Ser Pro Leu Phe Thr
225                 230                 235                 240 
Asp Thr Trp Thr Ala Asp Ile Pro Val Gly Thr Leu Cys Pro Glu Trp
                245                 250                 255     
Ala Gln Arg Leu Gly Leu Pro Glu Ser Val Val Ile Ser Gly Gly Ala
            260                 265                 270         
Phe Asp Cys His Met Gly Ala Val Gly Ala Gly Ala Gln Pro Asn Ala
        275                 280                 285             
Leu Val Lys Val Ile Gly Thr Ser Thr Cys Asp Ile Leu Ile Ala Asp
    290                 295                 300                 
Lys Gln Ser Val Gly Glu Arg Ala Val Lys Gly Ile Cys Gly Gln Val
305                 310                 315                 320 
Asp Gly Ser Val Val Pro Gly Phe Ile Gly Leu Glu Ala Gly Gln Ser
                325                 330                 335     
Ala Phe Gly Asp Ile Tyr Ala Trp Phe Gly Arg Val Leu Ser Trp Pro
            340                 345                 350         
Leu Glu Gln Leu Ala Ala Gln His Pro Glu Leu Lys Ala Gln Ile Asn
        355                 360                 365             
Ala Ser Gln Lys Gln Leu Leu Pro Ala Leu Thr Glu Ala Trp Ala Lys
    370                 375                 380                 
Asn Pro Ser Leu Asp His Leu Pro Val Val Leu Asp Trp Phe Asn Gly
385                 390                 395                 400 
Arg Arg Ser Pro Asn Ala Asn Gln Arg Leu Lys Gly Val Ile Thr Asp
                405                 410                 415     
Leu Asn Leu Ala Thr Asp Ala Pro Leu Leu Phe Gly Gly Leu Ile Ala
            420                 425                 430         
Ala Thr Ala Phe Gly Ala Arg Ala Ile Met Glu Cys Phe Thr Asp Gln
        435                 440                 445             
Gly Ile Ala Val Asn Asn Val Met Ala Leu Gly Gly Ile Ala Arg Lys
    450                 455                 460                 
Asn Gln Val Ile Met Gln Ala Cys Cys Asp Val Leu Asn Arg Pro Leu
465                 470                 475                 480 
Gln Ile Val Ala Ser Asp Gln Cys Cys Ala Leu Gly Ala Ala Ile Phe
                485                 490                 495     
Ala Ala Val Ala Ala Lys Val His Ala Asp Ile Pro Ser Ala Gln Gln
            500                 505                 510         
Lys Met Ala Ser Ala Val Glu Lys Thr Leu Gln Pro Arg Ser Glu Gln
        515                 520                 525             
Ala Gln Arg Phe Glu Gln Leu Tyr Arg Arg Tyr Gln Gln Trp Ala Met
    530                 535                 540                 
Ser Ala Glu Gln His Tyr Leu Pro Thr Ser Ala Pro Ala Gln Ala Ala
545                 550                 555                 560 
Gln Ala Val Ala Thr Leu
                565     


<210> 223
<211> 1720
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in S. cerevisiae

<220> 
<221> CDS            
<222> (12)...(1709)

<400> 223
tactcaagct t atg gct att gct att gga ttg gac ttt ggt tct gat tct  50
             Met Ala Ile Ala Ile Gly Leu Asp Phe Gly Ser Asp Ser
              1               5                   10
 
gtt aga gct ttg gct gtt gat tgt gct tct gga gaa gaa att gct act   98
Val Arg Ala Leu Ala Val Asp Cys Ala Ser Gly Glu Glu Ile Ala Thr
     15                  20                  25
 
tct gtt gaa tgg tat cct aga tgg caa aaa gga caa ttt tgt gat gct   146
Ser Val Glu Trp Tyr Pro Arg Trp Gln Lys Gly Gln Phe Cys Asp Ala
 30                  35                  40                  45
 
cca aat aat caa ttt aga cat cat cct aga gat tat att gaa tct atg   194
Pro Asn Asn Gln Phe Arg His His Pro Arg Asp Tyr Ile Glu Ser Met
                 50                  55                  60
 
gaa gct gct tta aaa act gtt ttg gct gaa ttg tct gtt gaa caa aga   242
Glu Ala Ala Leu Lys Thr Val Leu Ala Glu Leu Ser Val Glu Gln Arg
             65                  70                  75
 
gct gcc gtt gtt gga att gga gtt gat tct act gga tct act cct gct   290
Ala Ala Val Val Gly Ile Gly Val Asp Ser Thr Gly Ser Thr Pro Ala
         80                  85                  90
 
cca att gat gct gat gga aat gtg ttg gct ttg aga cca gaa ttt gca   338
Pro Ile Asp Ala Asp Gly Asn Val Leu Ala Leu Arg Pro Glu Phe Ala
     95                 100                 105
 
gaa aat cct aac gct atg ttt gtt ttg tgg aaa gat cat act gct gtt   386
Glu Asn Pro Asn Ala Met Phe Val Leu Trp Lys Asp His Thr Ala Val
110                 115                 120                 125
 
gaa aga tct gaa gaa att act aga ttg tgt cat gct cca gga aat gtt   434
Glu Arg Ser Glu Glu Ile Thr Arg Leu Cys His Ala Pro Gly Asn Val
                130                 135                 140
 
gat tat tct aga tat att gga gga att tat tct tct gaa tgg ttt tgg   482
Asp Tyr Ser Arg Tyr Ile Gly Gly Ile Tyr Ser Ser Glu Trp Phe Trp
            145                 150                 155
 
gct aaa att ttg cat gtt act aga caa gat tct gct gtg gct caa tct   530
Ala Lys Ile Leu His Val Thr Arg Gln Asp Ser Ala Val Ala Gln Ser
        160                 165                 170
 
gct gct tct tgg att gaa ttg tgt gat tgg gtt cca gct tta ttg agt   578
Ala Ala Ser Trp Ile Glu Leu Cys Asp Trp Val Pro Ala Leu Leu Ser
    175                 180                 185
 
gga aca act aga cca caa gac att aga aga ggt aga tgt tct gct ggg   626
Gly Thr Thr Arg Pro Gln Asp Ile Arg Arg Gly Arg Cys Ser Ala Gly
190                 195                 200                 205
 
cat aaa tca ttg tgg cat gaa tct tgg ggt ggt ttg cct cct gct tca   674
His Lys Ser Leu Trp His Glu Ser Trp Gly Gly Leu Pro Pro Ala Ser
                210                 215                 220
 
ttc ttt gat gaa ttg gac cca att tta aat aga cat ttg cca tct cca   722
Phe Phe Asp Glu Leu Asp Pro Ile Leu Asn Arg His Leu Pro Ser Pro
            225                 230                 235
 
ttg ttt act gat act tgg act gct gat ata cca gtt ggt act tta tgt   770
Leu Phe Thr Asp Thr Trp Thr Ala Asp Ile Pro Val Gly Thr Leu Cys
        240                 245                 250
 
cca gaa tgg gct caa aga ttg gga ttg cca gaa tct gtt gtt att tca   818
Pro Glu Trp Ala Gln Arg Leu Gly Leu Pro Glu Ser Val Val Ile Ser
    255                 260                 265
 
gga gga gct ttt gat tgt cac atg gga gct gtt ggt gct ggc gct caa   866
Gly Gly Ala Phe Asp Cys His Met Gly Ala Val Gly Ala Gly Ala Gln
270                 275                 280                 285
 
cct aat gca ttg gtt aaa gtt att gga aca tct act tgt gac att ttg   914
Pro Asn Ala Leu Val Lys Val Ile Gly Thr Ser Thr Cys Asp Ile Leu
                290                 295                 300
 
att gct gat aaa caa tct gtt gga gaa aga gct gtt aaa gga att tgt   962
Ile Ala Asp Lys Gln Ser Val Gly Glu Arg Ala Val Lys Gly Ile Cys
            305                 310                 315
 
gga caa gtt gat gga tct gtt gtt cca gga ttt att gga tta gaa gct   1010
Gly Gln Val Asp Gly Ser Val Val Pro Gly Phe Ile Gly Leu Glu Ala
        320                 325                 330
 
gga caa tct gct ttt ggt gac att tat gct tgg ttt ggt aga gtt ttg   1058
Gly Gln Ser Ala Phe Gly Asp Ile Tyr Ala Trp Phe Gly Arg Val Leu
    335                 340                 345
 
tct tgg cca tta gaa caa ctc gct gct caa cat cca gaa tta aaa gct   1106
Ser Trp Pro Leu Glu Gln Leu Ala Ala Gln His Pro Glu Leu Lys Ala
350                 355                 360                 365
 
caa att aac gct tct caa aaa caa ttg ttg cca gct ttg act gaa gca   1154
Gln Ile Asn Ala Ser Gln Lys Gln Leu Leu Pro Ala Leu Thr Glu Ala
                370                 375                 380
 
tgg gct aaa aat cca tct tta gat cat ttg cca gtt gtt ttg gat tgg   1202
Trp Ala Lys Asn Pro Ser Leu Asp His Leu Pro Val Val Leu Asp Trp
            385                 390                 395
 
ttt aat ggt aga aga tct cca aat gca aat caa aga tta aaa gga gtt   1250
Phe Asn Gly Arg Arg Ser Pro Asn Ala Asn Gln Arg Leu Lys Gly Val
        400                 405                 410
 
att act gat tta aat ttg gct act gat gct cca ttg ttg ttt ggt gga   1298
Ile Thr Asp Leu Asn Leu Ala Thr Asp Ala Pro Leu Leu Phe Gly Gly
    415                 420                 425
 
ttg att gct gct act gct ttt ggt gct aga gct att atg gaa tgt ttt   1346
Leu Ile Ala Ala Thr Ala Phe Gly Ala Arg Ala Ile Met Glu Cys Phe
430                 435                 440                 445
 
act gat cag gga att gct gtt aat aat gtt atg gct ttg gga gga att   1394
Thr Asp Gln Gly Ile Ala Val Asn Asn Val Met Ala Leu Gly Gly Ile
                450                 455                 460
 
gca agg aaa aat caa gtt att atg cag gct tgt tgt gac gtt tta aat   1442
Ala Arg Lys Asn Gln Val Ile Met Gln Ala Cys Cys Asp Val Leu Asn
            465                 470                 475
 
aga cca ttg caa att gta gct tct gat caa tgt tgt gct tta gga gct   1490
Arg Pro Leu Gln Ile Val Ala Ser Asp Gln Cys Cys Ala Leu Gly Ala
        480                 485                 490
 
gct att ttc gct gcc gta gct gca aaa gtt cat gcc gat ata cca tct   1538
Ala Ile Phe Ala Ala Val Ala Ala Lys Val His Ala Asp Ile Pro Ser
    495                 500                 505
 
gct caa cag aaa atg gct tcg gct gta gaa aag aca ttg caa cct aga   1586
Ala Gln Gln Lys Met Ala Ser Ala Val Glu Lys Thr Leu Gln Pro Arg
510                 515                 520                 525
 
tct gaa caa gca caa aga ttt gag caa ttg tat aga aga tat caa caa   1634
Ser Glu Gln Ala Gln Arg Phe Glu Gln Leu Tyr Arg Arg Tyr Gln Gln
                530                 535                 540
 
tgg gct atg agt gct gaa caa cat tat ttg cca act tct gca cct gct   1682
Trp Ala Met Ser Ala Glu Gln His Tyr Leu Pro Thr Ser Ala Pro Ala
            545                 550                 555
 
cag gct gca caa gct gta gct act tta gaattccgat g                  1720
Gln Ala Ala Gln Ala Val Ala Thr Leu
        560                 565
 

<210> 224
<211> 566
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in S. cerevisiae

<400> 224
Met Ala Ile Ala Ile Gly Leu Asp Phe Gly Ser Asp Ser Val Arg Ala
 1               5                  10                  15      
Leu Ala Val Asp Cys Ala Ser Gly Glu Glu Ile Ala Thr Ser Val Glu
            20                  25                  30          
Trp Tyr Pro Arg Trp Gln Lys Gly Gln Phe Cys Asp Ala Pro Asn Asn
        35                  40                  45              
Gln Phe Arg His His Pro Arg Asp Tyr Ile Glu Ser Met Glu Ala Ala
    50                  55                  60                  
Leu Lys Thr Val Leu Ala Glu Leu Ser Val Glu Gln Arg Ala Ala Val
65                  70                  75                  80  
Val Gly Ile Gly Val Asp Ser Thr Gly Ser Thr Pro Ala Pro Ile Asp
                85                  90                  95      
Ala Asp Gly Asn Val Leu Ala Leu Arg Pro Glu Phe Ala Glu Asn Pro
            100                 105                 110         
Asn Ala Met Phe Val Leu Trp Lys Asp His Thr Ala Val Glu Arg Ser
        115                 120                 125             
Glu Glu Ile Thr Arg Leu Cys His Ala Pro Gly Asn Val Asp Tyr Ser
    130                 135                 140                 
Arg Tyr Ile Gly Gly Ile Tyr Ser Ser Glu Trp Phe Trp Ala Lys Ile
145                 150                 155                 160 
Leu His Val Thr Arg Gln Asp Ser Ala Val Ala Gln Ser Ala Ala Ser
                165                 170                 175     
Trp Ile Glu Leu Cys Asp Trp Val Pro Ala Leu Leu Ser Gly Thr Thr
            180                 185                 190         
Arg Pro Gln Asp Ile Arg Arg Gly Arg Cys Ser Ala Gly His Lys Ser
        195                 200                 205             
Leu Trp His Glu Ser Trp Gly Gly Leu Pro Pro Ala Ser Phe Phe Asp
    210                 215                 220                 
Glu Leu Asp Pro Ile Leu Asn Arg His Leu Pro Ser Pro Leu Phe Thr
225                 230                 235                 240 
Asp Thr Trp Thr Ala Asp Ile Pro Val Gly Thr Leu Cys Pro Glu Trp
                245                 250                 255     
Ala Gln Arg Leu Gly Leu Pro Glu Ser Val Val Ile Ser Gly Gly Ala
            260                 265                 270         
Phe Asp Cys His Met Gly Ala Val Gly Ala Gly Ala Gln Pro Asn Ala
        275                 280                 285             
Leu Val Lys Val Ile Gly Thr Ser Thr Cys Asp Ile Leu Ile Ala Asp
    290                 295                 300                 
Lys Gln Ser Val Gly Glu Arg Ala Val Lys Gly Ile Cys Gly Gln Val
305                 310                 315                 320 
Asp Gly Ser Val Val Pro Gly Phe Ile Gly Leu Glu Ala Gly Gln Ser
                325                 330                 335     
Ala Phe Gly Asp Ile Tyr Ala Trp Phe Gly Arg Val Leu Ser Trp Pro
            340                 345                 350         
Leu Glu Gln Leu Ala Ala Gln His Pro Glu Leu Lys Ala Gln Ile Asn
        355                 360                 365             
Ala Ser Gln Lys Gln Leu Leu Pro Ala Leu Thr Glu Ala Trp Ala Lys
    370                 375                 380                 
Asn Pro Ser Leu Asp His Leu Pro Val Val Leu Asp Trp Phe Asn Gly
385                 390                 395                 400 
Arg Arg Ser Pro Asn Ala Asn Gln Arg Leu Lys Gly Val Ile Thr Asp
                405                 410                 415     
Leu Asn Leu Ala Thr Asp Ala Pro Leu Leu Phe Gly Gly Leu Ile Ala
            420                 425                 430         
Ala Thr Ala Phe Gly Ala Arg Ala Ile Met Glu Cys Phe Thr Asp Gln
        435                 440                 445             
Gly Ile Ala Val Asn Asn Val Met Ala Leu Gly Gly Ile Ala Arg Lys
    450                 455                 460                 
Asn Gln Val Ile Met Gln Ala Cys Cys Asp Val Leu Asn Arg Pro Leu
465                 470                 475                 480 
Gln Ile Val Ala Ser Asp Gln Cys Cys Ala Leu Gly Ala Ala Ile Phe
                485                 490                 495     
Ala Ala Val Ala Ala Lys Val His Ala Asp Ile Pro Ser Ala Gln Gln
            500                 505                 510         
Lys Met Ala Ser Ala Val Glu Lys Thr Leu Gln Pro Arg Ser Glu Gln
        515                 520                 525             
Ala Gln Arg Phe Glu Gln Leu Tyr Arg Arg Tyr Gln Gln Trp Ala Met
    530                 535                 540                 
Ser Ala Glu Gln His Tyr Leu Pro Thr Ser Ala Pro Ala Gln Ala Ala
545                 550                 555                 560 
Gln Ala Val Ala Thr Leu
                565     


<210> 225
<211> 1698
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in E. coli

<220> 
<221> CDS            
<222> (1)...(1698)

<400> 225
atg gct atc gcg atc ggt ctg gac ttc ggt tct gac tct gtt cgt gct   48
Met Ala Ile Ala Ile Gly Leu Asp Phe Gly Ser Asp Ser Val Arg Ala
 1               5                   10                  15
 
ctg gct gtt gac tgc gcg tct ggt gaa gaa att gcg acc tct gtt gaa   96
Leu Ala Val Asp Cys Ala Ser Gly Glu Glu Ile Ala Thr Ser Val Glu
             20                  25                  30
 
tgg tat ccg cgt tgg cag aaa ggt cag ttt tgc gac gct ccg aac aac   144
Trp Tyr Pro Arg Trp Gln Lys Gly Gln Phe Cys Asp Ala Pro Asn Asn
         35                  40                  45
 
cag ttt cgt cac cac ccg cgt gac tac atc gaa tct atg gaa gct gct   192
Gln Phe Arg His His Pro Arg Asp Tyr Ile Glu Ser Met Glu Ala Ala
     50                  55                  60
 
ctg aaa acc gtg ctg gct gag ctg tct gtt gaa cag cgt gcg gcg gtt   240
Leu Lys Thr Val Leu Ala Glu Leu Ser Val Glu Gln Arg Ala Ala Val
 65                  70                  75                  80
 
gtt ggt atc ggt gtt gac tct acc ggt tct acc ccg gct ccg atc gat   288
Val Gly Ile Gly Val Asp Ser Thr Gly Ser Thr Pro Ala Pro Ile Asp
                 85                  90                  95
 
gcg gac ggt aat gtt ctg gct ctg cgt cca gaa ttt gcg gaa aac cca   336
Ala Asp Gly Asn Val Leu Ala Leu Arg Pro Glu Phe Ala Glu Asn Pro
            100                 105                 110
 
aac gct atg ttc gtt ctg tgg aaa gat cac acc gct gtt gaa cgt tct   384
Asn Ala Met Phe Val Leu Trp Lys Asp His Thr Ala Val Glu Arg Ser
        115                 120                 125
 
gaa gaa atc acc cgt ctg tgc cac gct ccg ggc aat gtt gac tac tct   432
Glu Glu Ile Thr Arg Leu Cys His Ala Pro Gly Asn Val Asp Tyr Ser
    130                 135                 140
 
cgt tac atc ggt ggt atc tac tct tct gaa tgg ttt tgg gcg aaa atc   480
Arg Tyr Ile Gly Gly Ile Tyr Ser Ser Glu Trp Phe Trp Ala Lys Ile
145                 150                 155                 160
 
ctg cat gtt acc cgt caa gat tct gcg gtt gct cag tct gct gct tct   528
Leu His Val Thr Arg Gln Asp Ser Ala Val Ala Gln Ser Ala Ala Ser
                165                 170                 175
 
tgg atc gaa ctg tgc gat tgg gtt ccg gct ctg ctg tct ggt act acc   576
Trp Ile Glu Leu Cys Asp Trp Val Pro Ala Leu Leu Ser Gly Thr Thr
            180                 185                 190
 
cgt ccg caa gac atc cgt cgt ggt cgt tgc tct gcg ggt cac aaa tct   624
Arg Pro Gln Asp Ile Arg Arg Gly Arg Cys Ser Ala Gly His Lys Ser
        195                 200                 205
 
ctc tgg cat gaa tcc tgg ggt ggt ttg cct ccg gcg tcc ttc ttc gac   672
Leu Trp His Glu Ser Trp Gly Gly Leu Pro Pro Ala Ser Phe Phe Asp
    210                 215                 220
 
gaa ctg gac ccg atc ctg aac cgt cac ctg ccg tct ccg ctg ttc acc   720
Glu Leu Asp Pro Ile Leu Asn Arg His Leu Pro Ser Pro Leu Phe Thr
225                 230                 235                 240
 
gac act tgg act gcg gac atc ccg gtt ggc acc ctc tgt cca gag tgg   768
Asp Thr Trp Thr Ala Asp Ile Pro Val Gly Thr Leu Cys Pro Glu Trp
                245                 250                 255
 
gca cag cgc ctg ggt ctc ccg gag tct gtt gtt atc agc ggt ggt gct   816
Ala Gln Arg Leu Gly Leu Pro Glu Ser Val Val Ile Ser Gly Gly Ala
            260                 265                 270
 
ttt gac tgc cac atg ggt gcg gtt ggt gca ggt gct cag cca aat gcg   864
Phe Asp Cys His Met Gly Ala Val Gly Ala Gly Ala Gln Pro Asn Ala
        275                 280                 285
 
ctc gtt aaa gtt atc ggt act tct acc tgc gac atc ctg atc gcg gac   912
Leu Val Lys Val Ile Gly Thr Ser Thr Cys Asp Ile Leu Ile Ala Asp
    290                 295                 300
 
aaa cag tct gtt ggt gag cgt gcg gtt aaa ggt atc tgc ggt cag gtt   960
Lys Gln Ser Val Gly Glu Arg Ala Val Lys Gly Ile Cys Gly Gln Val
305                 310                 315                 320
 
gac ggt tct gtt gtt ccg ggt ttc att ggt ctg gag gct ggt cag tct   1008
Asp Gly Ser Val Val Pro Gly Phe Ile Gly Leu Glu Ala Gly Gln Ser
                325                 330                 335
 
gct ttc ggt gac atc tac gcg tgg ttc ggt cgt gtt ctg tct tgg ccg   1056
Ala Phe Gly Asp Ile Tyr Ala Trp Phe Gly Arg Val Leu Ser Trp Pro
            340                 345                 350
 
ctc gaa cag ctc gca gcg cag cat ccg gaa ctg aaa gct cag atc aac   1104
Leu Glu Gln Leu Ala Ala Gln His Pro Glu Leu Lys Ala Gln Ile Asn
        355                 360                 365
 
gcg tct cag aaa cag ctg ctg cct gcg ctc acc gag gcg tgg gct aaa   1152
Ala Ser Gln Lys Gln Leu Leu Pro Ala Leu Thr Glu Ala Trp Ala Lys
    370                 375                 380
 
aac ccg tct ctg gac cac ctg ccg gtt gtt ctg gat tgg ttc aat ggt   1200
Asn Pro Ser Leu Asp His Leu Pro Val Val Leu Asp Trp Phe Asn Gly
385                 390                 395                 400
 
cgt cgt tct ccg aat gcg aac cag cgt ctg aaa ggt gtt atc acc gac   1248
Arg Arg Ser Pro Asn Ala Asn Gln Arg Leu Lys Gly Val Ile Thr Asp
                405                 410                 415
 
ctg aac ctg gct act gac gct ccg ctc ctg ttc ggt ggt ctc atc gcg   1296
Leu Asn Leu Ala Thr Asp Ala Pro Leu Leu Phe Gly Gly Leu Ile Ala
            420                 425                 430
 
gct act gca ttc ggc gct cgt gct atc atg gaa tgc ttt acc gac caa   1344
Ala Thr Ala Phe Gly Ala Arg Ala Ile Met Glu Cys Phe Thr Asp Gln
        435                 440                 445
 
ggc atc gcg gtt aac aac gtt atg gct ctg ggt ggt att gcg cgt aaa   1392
Gly Ile Ala Val Asn Asn Val Met Ala Leu Gly Gly Ile Ala Arg Lys
    450                 455                 460
 
aac cag gtt atc atg caa gcg tgc tgc gac gtt ctg aac cgc ccg ctc   1440
Asn Gln Val Ile Met Gln Ala Cys Cys Asp Val Leu Asn Arg Pro Leu
465                 470                 475                 480
 
cag att gtt gcg tct gac cag tgt tgt gcg ttg ggt gct gct att ttt   1488
Gln Ile Val Ala Ser Asp Gln Cys Cys Ala Leu Gly Ala Ala Ile Phe
                485                 490                 495
 
gcg gct gtt gca gct aag gtt cac gct gat att ccg agc gca cag cag   1536
Ala Ala Val Ala Ala Lys Val His Ala Asp Ile Pro Ser Ala Gln Gln
            500                 505                 510
 
aaa atg gct tct gcg gtt gaa aag acc ctc cag cca cgt tct gaa caa   1584
Lys Met Ala Ser Ala Val Glu Lys Thr Leu Gln Pro Arg Ser Glu Gln
        515                 520                 525
 
gcg cag cgt ttc gaa cag ctg tac cgt cgt tac cag cag tgg gct atg   1632
Ala Gln Arg Phe Glu Gln Leu Tyr Arg Arg Tyr Gln Gln Trp Ala Met
    530                 535                 540
 
tct gcg gaa cag cac tac ctc ccg act agc gct cct gct caa gcg gcc   1680
Ser Ala Glu Gln His Tyr Leu Pro Thr Ser Ala Pro Ala Gln Ala Ala
545                 550                 555                 560
 
caa gca gtt gcg acc ctg                                           1698
Gln Ala Val Ala Thr Leu
                565
 

<210> 226
<211> 566
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in E. coli

<400> 226
Met Ala Ile Ala Ile Gly Leu Asp Phe Gly Ser Asp Ser Val Arg Ala
 1               5                  10                  15      
Leu Ala Val Asp Cys Ala Ser Gly Glu Glu Ile Ala Thr Ser Val Glu
            20                  25                  30          
Trp Tyr Pro Arg Trp Gln Lys Gly Gln Phe Cys Asp Ala Pro Asn Asn
        35                  40                  45              
Gln Phe Arg His His Pro Arg Asp Tyr Ile Glu Ser Met Glu Ala Ala
    50                  55                  60                  
Leu Lys Thr Val Leu Ala Glu Leu Ser Val Glu Gln Arg Ala Ala Val
65                  70                  75                  80  
Val Gly Ile Gly Val Asp Ser Thr Gly Ser Thr Pro Ala Pro Ile Asp
                85                  90                  95      
Ala Asp Gly Asn Val Leu Ala Leu Arg Pro Glu Phe Ala Glu Asn Pro
            100                 105                 110         
Asn Ala Met Phe Val Leu Trp Lys Asp His Thr Ala Val Glu Arg Ser
        115                 120                 125             
Glu Glu Ile Thr Arg Leu Cys His Ala Pro Gly Asn Val Asp Tyr Ser
    130                 135                 140                 
Arg Tyr Ile Gly Gly Ile Tyr Ser Ser Glu Trp Phe Trp Ala Lys Ile
145                 150                 155                 160 
Leu His Val Thr Arg Gln Asp Ser Ala Val Ala Gln Ser Ala Ala Ser
                165                 170                 175     
Trp Ile Glu Leu Cys Asp Trp Val Pro Ala Leu Leu Ser Gly Thr Thr
            180                 185                 190         
Arg Pro Gln Asp Ile Arg Arg Gly Arg Cys Ser Ala Gly His Lys Ser
        195                 200                 205             
Leu Trp His Glu Ser Trp Gly Gly Leu Pro Pro Ala Ser Phe Phe Asp
    210                 215                 220                 
Glu Leu Asp Pro Ile Leu Asn Arg His Leu Pro Ser Pro Leu Phe Thr
225                 230                 235                 240 
Asp Thr Trp Thr Ala Asp Ile Pro Val Gly Thr Leu Cys Pro Glu Trp
                245                 250                 255     
Ala Gln Arg Leu Gly Leu Pro Glu Ser Val Val Ile Ser Gly Gly Ala
            260                 265                 270         
Phe Asp Cys His Met Gly Ala Val Gly Ala Gly Ala Gln Pro Asn Ala
        275                 280                 285             
Leu Val Lys Val Ile Gly Thr Ser Thr Cys Asp Ile Leu Ile Ala Asp
    290                 295                 300                 
Lys Gln Ser Val Gly Glu Arg Ala Val Lys Gly Ile Cys Gly Gln Val
305                 310                 315                 320 
Asp Gly Ser Val Val Pro Gly Phe Ile Gly Leu Glu Ala Gly Gln Ser
                325                 330                 335     
Ala Phe Gly Asp Ile Tyr Ala Trp Phe Gly Arg Val Leu Ser Trp Pro
            340                 345                 350         
Leu Glu Gln Leu Ala Ala Gln His Pro Glu Leu Lys Ala Gln Ile Asn
        355                 360                 365             
Ala Ser Gln Lys Gln Leu Leu Pro Ala Leu Thr Glu Ala Trp Ala Lys
    370                 375                 380                 
Asn Pro Ser Leu Asp His Leu Pro Val Val Leu Asp Trp Phe Asn Gly
385                 390                 395                 400 
Arg Arg Ser Pro Asn Ala Asn Gln Arg Leu Lys Gly Val Ile Thr Asp
                405                 410                 415     
Leu Asn Leu Ala Thr Asp Ala Pro Leu Leu Phe Gly Gly Leu Ile Ala
            420                 425                 430         
Ala Thr Ala Phe Gly Ala Arg Ala Ile Met Glu Cys Phe Thr Asp Gln
        435                 440                 445             
Gly Ile Ala Val Asn Asn Val Met Ala Leu Gly Gly Ile Ala Arg Lys
    450                 455                 460                 
Asn Gln Val Ile Met Gln Ala Cys Cys Asp Val Leu Asn Arg Pro Leu
465                 470                 475                 480 
Gln Ile Val Ala Ser Asp Gln Cys Cys Ala Leu Gly Ala Ala Ile Phe
                485                 490                 495     
Ala Ala Val Ala Ala Lys Val His Ala Asp Ile Pro Ser Ala Gln Gln
            500                 505                 510         
Lys Met Ala Ser Ala Val Glu Lys Thr Leu Gln Pro Arg Ser Glu Gln
        515                 520                 525             
Ala Gln Arg Phe Glu Gln Leu Tyr Arg Arg Tyr Gln Gln Trp Ala Met
    530                 535                 540                 
Ser Ala Glu Gln His Tyr Leu Pro Thr Ser Ala Pro Ala Gln Ala Ala
545                 550                 555                 560 
Gln Ala Val Ala Thr Leu
                565     


<210> 227
<211> 1720
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in E. coli

<220> 
<221> CDS            
<222> (12)...(1709)

<400> 227
tactcaagct t atg gct atc gcg atc ggt ctg gac ttc ggt tct gac tct  50
             Met Ala Ile Ala Ile Gly Leu Asp Phe Gly Ser Asp Ser
              1               5                   10
 
gtt cgt gct ctg gct gtt gac tgc gcg tct ggt gaa gaa att gcg acc   98
Val Arg Ala Leu Ala Val Asp Cys Ala Ser Gly Glu Glu Ile Ala Thr
     15                  20                  25
 
tct gtt gaa tgg tat ccg cgt tgg cag aaa ggt cag ttt tgc gac gct   146
Ser Val Glu Trp Tyr Pro Arg Trp Gln Lys Gly Gln Phe Cys Asp Ala
 30                  35                  40                  45
 
ccg aac aac cag ttt cgt cac cac ccg cgt gac tac atc gaa tct atg   194
Pro Asn Asn Gln Phe Arg His His Pro Arg Asp Tyr Ile Glu Ser Met
                 50                  55                  60
 
gaa gct gct ctg aaa acc gtg ctg gct gag ctg tct gtt gaa cag cgt   242
Glu Ala Ala Leu Lys Thr Val Leu Ala Glu Leu Ser Val Glu Gln Arg
             65                  70                  75
 
gcg gcg gtt gtt ggt atc ggt gtt gac tct acc ggt tct acc ccg gct   290
Ala Ala Val Val Gly Ile Gly Val Asp Ser Thr Gly Ser Thr Pro Ala
         80                  85                  90
 
ccg atc gat gcg gac ggt aat gtt ctg gct ctg cgt cca gaa ttt gcg   338
Pro Ile Asp Ala Asp Gly Asn Val Leu Ala Leu Arg Pro Glu Phe Ala
     95                 100                 105
 
gaa aac cca aac gct atg ttc gtt ctg tgg aaa gat cac acc gct gtt   386
Glu Asn Pro Asn Ala Met Phe Val Leu Trp Lys Asp His Thr Ala Val
110                 115                 120                 125
 
gaa cgt tct gaa gaa atc acc cgt ctg tgc cac gct ccg ggc aat gtt   434
Glu Arg Ser Glu Glu Ile Thr Arg Leu Cys His Ala Pro Gly Asn Val
                130                 135                 140
 
gac tac tct cgt tac atc ggt ggt atc tac tct tct gaa tgg ttt tgg   482
Asp Tyr Ser Arg Tyr Ile Gly Gly Ile Tyr Ser Ser Glu Trp Phe Trp
            145                 150                 155
 
gcg aaa atc ctg cat gtt acc cgt caa gat tct gcg gtt gct cag tct   530
Ala Lys Ile Leu His Val Thr Arg Gln Asp Ser Ala Val Ala Gln Ser
        160                 165                 170
 
gct gct tct tgg atc gaa ctg tgc gat tgg gtt ccg gct ctg ctg tct   578
Ala Ala Ser Trp Ile Glu Leu Cys Asp Trp Val Pro Ala Leu Leu Ser
    175                 180                 185
 
ggt act acc cgt ccg caa gac atc cgt cgt ggt cgt tgc tct gcg ggt   626
Gly Thr Thr Arg Pro Gln Asp Ile Arg Arg Gly Arg Cys Ser Ala Gly
190                 195                 200                 205
 
cac aaa tct ctc tgg cat gaa tcc tgg ggt ggt ttg cct ccg gcg tcc   674
His Lys Ser Leu Trp His Glu Ser Trp Gly Gly Leu Pro Pro Ala Ser
                210                 215                 220
 
ttc ttc gac gaa ctg gac ccg atc ctg aac cgt cac ctg ccg tct ccg   722
Phe Phe Asp Glu Leu Asp Pro Ile Leu Asn Arg His Leu Pro Ser Pro
            225                 230                 235
 
ctg ttc acc gac act tgg act gcg gac atc ccg gtt ggc acc ctc tgt   770
Leu Phe Thr Asp Thr Trp Thr Ala Asp Ile Pro Val Gly Thr Leu Cys
        240                 245                 250
 
cca gag tgg gca cag cgc ctg ggt ctc ccg gag tct gtt gtt atc agc   818
Pro Glu Trp Ala Gln Arg Leu Gly Leu Pro Glu Ser Val Val Ile Ser
    255                 260                 265
 
ggt ggt gct ttt gac tgc cac atg ggt gcg gtt ggt gca ggt gct cag   866
Gly Gly Ala Phe Asp Cys His Met Gly Ala Val Gly Ala Gly Ala Gln
270                 275                 280                 285
 
cca aat gcg ctc gtt aaa gtt atc ggt act tct acc tgc gac atc ctg   914
Pro Asn Ala Leu Val Lys Val Ile Gly Thr Ser Thr Cys Asp Ile Leu
                290                 295                 300
 
atc gcg gac aaa cag tct gtt ggt gag cgt gcg gtt aaa ggt atc tgc   962
Ile Ala Asp Lys Gln Ser Val Gly Glu Arg Ala Val Lys Gly Ile Cys
            305                 310                 315
 
ggt cag gtt gac ggt tct gtt gtt ccg ggt ttc att ggt ctg gag gct   1010
Gly Gln Val Asp Gly Ser Val Val Pro Gly Phe Ile Gly Leu Glu Ala
        320                 325                 330
 
ggt cag tct gct ttc ggt gac atc tac gcg tgg ttc ggt cgt gtt ctg   1058
Gly Gln Ser Ala Phe Gly Asp Ile Tyr Ala Trp Phe Gly Arg Val Leu
    335                 340                 345
 
tct tgg ccg ctc gaa cag ctc gca gcg cag cat ccg gaa ctg aaa gct   1106
Ser Trp Pro Leu Glu Gln Leu Ala Ala Gln His Pro Glu Leu Lys Ala
350                 355                 360                 365
 
cag atc aac gcg tct cag aaa cag ctg ctg cct gcg ctc acc gag gcg   1154
Gln Ile Asn Ala Ser Gln Lys Gln Leu Leu Pro Ala Leu Thr Glu Ala
                370                 375                 380
 
tgg gct aaa aac ccg tct ctg gac cac ctg ccg gtt gtt ctg gat tgg   1202
Trp Ala Lys Asn Pro Ser Leu Asp His Leu Pro Val Val Leu Asp Trp
            385                 390                 395
 
ttc aat ggt cgt cgt tct ccg aat gcg aac cag cgt ctg aaa ggt gtt   1250
Phe Asn Gly Arg Arg Ser Pro Asn Ala Asn Gln Arg Leu Lys Gly Val
        400                 405                 410
 
atc acc gac ctg aac ctg gct act gac gct ccg ctc ctg ttc ggt ggt   1298
Ile Thr Asp Leu Asn Leu Ala Thr Asp Ala Pro Leu Leu Phe Gly Gly
    415                 420                 425
 
ctc atc gcg gct act gca ttc ggc gct cgt gct atc atg gaa tgc ttt   1346
Leu Ile Ala Ala Thr Ala Phe Gly Ala Arg Ala Ile Met Glu Cys Phe
430                 435                 440                 445
 
acc gac caa ggc atc gcg gtt aac aac gtt atg gct ctg ggt ggt att   1394
Thr Asp Gln Gly Ile Ala Val Asn Asn Val Met Ala Leu Gly Gly Ile
                450                 455                 460
 
gcg cgt aaa aac cag gtt atc atg caa gcg tgc tgc gac gtt ctg aac   1442
Ala Arg Lys Asn Gln Val Ile Met Gln Ala Cys Cys Asp Val Leu Asn
            465                 470                 475
 
cgc ccg ctc cag att gtt gcg tct gac cag tgt tgt gcg ttg ggt gct   1490
Arg Pro Leu Gln Ile Val Ala Ser Asp Gln Cys Cys Ala Leu Gly Ala
        480                 485                 490
 
gct att ttt gcg gct gtt gca gct aag gtt cac gct gat att ccg agc   1538
Ala Ile Phe Ala Ala Val Ala Ala Lys Val His Ala Asp Ile Pro Ser
    495                 500                 505
 
gca cag cag aaa atg gct tct gcg gtt gaa aag acc ctc cag cca cgt   1586
Ala Gln Gln Lys Met Ala Ser Ala Val Glu Lys Thr Leu Gln Pro Arg
510                 515                 520                 525
 
tct gaa caa gcg cag cgt ttc gaa cag ctg tac cgt cgt tac cag cag   1634
Ser Glu Gln Ala Gln Arg Phe Glu Gln Leu Tyr Arg Arg Tyr Gln Gln
                530                 535                 540
 
tgg gct atg tct gcg gaa cag cac tac ctc ccg act agc gct cct gct   1682
Trp Ala Met Ser Ala Glu Gln His Tyr Leu Pro Thr Ser Ala Pro Ala
            545                 550                 555
 
caa gcg gcc caa gca gtt gcg acc ctg gaattccgat g                  1720
Gln Ala Ala Gln Ala Val Ala Thr Leu
        560                 565
 

<210> 228
<211> 566
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in E. coli

<400> 228
Met Ala Ile Ala Ile Gly Leu Asp Phe Gly Ser Asp Ser Val Arg Ala
 1               5                  10                  15      
Leu Ala Val Asp Cys Ala Ser Gly Glu Glu Ile Ala Thr Ser Val Glu
            20                  25                  30          
Trp Tyr Pro Arg Trp Gln Lys Gly Gln Phe Cys Asp Ala Pro Asn Asn
        35                  40                  45              
Gln Phe Arg His His Pro Arg Asp Tyr Ile Glu Ser Met Glu Ala Ala
    50                  55                  60                  
Leu Lys Thr Val Leu Ala Glu Leu Ser Val Glu Gln Arg Ala Ala Val
65                  70                  75                  80  
Val Gly Ile Gly Val Asp Ser Thr Gly Ser Thr Pro Ala Pro Ile Asp
                85                  90                  95      
Ala Asp Gly Asn Val Leu Ala Leu Arg Pro Glu Phe Ala Glu Asn Pro
            100                 105                 110         
Asn Ala Met Phe Val Leu Trp Lys Asp His Thr Ala Val Glu Arg Ser
        115                 120                 125             
Glu Glu Ile Thr Arg Leu Cys His Ala Pro Gly Asn Val Asp Tyr Ser
    130                 135                 140                 
Arg Tyr Ile Gly Gly Ile Tyr Ser Ser Glu Trp Phe Trp Ala Lys Ile
145                 150                 155                 160 
Leu His Val Thr Arg Gln Asp Ser Ala Val Ala Gln Ser Ala Ala Ser
                165                 170                 175     
Trp Ile Glu Leu Cys Asp Trp Val Pro Ala Leu Leu Ser Gly Thr Thr
            180                 185                 190         
Arg Pro Gln Asp Ile Arg Arg Gly Arg Cys Ser Ala Gly His Lys Ser
        195                 200                 205             
Leu Trp His Glu Ser Trp Gly Gly Leu Pro Pro Ala Ser Phe Phe Asp
    210                 215                 220                 
Glu Leu Asp Pro Ile Leu Asn Arg His Leu Pro Ser Pro Leu Phe Thr
225                 230                 235                 240 
Asp Thr Trp Thr Ala Asp Ile Pro Val Gly Thr Leu Cys Pro Glu Trp
                245                 250                 255     
Ala Gln Arg Leu Gly Leu Pro Glu Ser Val Val Ile Ser Gly Gly Ala
            260                 265                 270         
Phe Asp Cys His Met Gly Ala Val Gly Ala Gly Ala Gln Pro Asn Ala
        275                 280                 285             
Leu Val Lys Val Ile Gly Thr Ser Thr Cys Asp Ile Leu Ile Ala Asp
    290                 295                 300                 
Lys Gln Ser Val Gly Glu Arg Ala Val Lys Gly Ile Cys Gly Gln Val
305                 310                 315                 320 
Asp Gly Ser Val Val Pro Gly Phe Ile Gly Leu Glu Ala Gly Gln Ser
                325                 330                 335     
Ala Phe Gly Asp Ile Tyr Ala Trp Phe Gly Arg Val Leu Ser Trp Pro
            340                 345                 350         
Leu Glu Gln Leu Ala Ala Gln His Pro Glu Leu Lys Ala Gln Ile Asn
        355                 360                 365             
Ala Ser Gln Lys Gln Leu Leu Pro Ala Leu Thr Glu Ala Trp Ala Lys
    370                 375                 380                 
Asn Pro Ser Leu Asp His Leu Pro Val Val Leu Asp Trp Phe Asn Gly
385                 390                 395                 400 
Arg Arg Ser Pro Asn Ala Asn Gln Arg Leu Lys Gly Val Ile Thr Asp
                405                 410                 415     
Leu Asn Leu Ala Thr Asp Ala Pro Leu Leu Phe Gly Gly Leu Ile Ala
            420                 425                 430         
Ala Thr Ala Phe Gly Ala Arg Ala Ile Met Glu Cys Phe Thr Asp Gln
        435                 440                 445             
Gly Ile Ala Val Asn Asn Val Met Ala Leu Gly Gly Ile Ala Arg Lys
    450                 455                 460                 
Asn Gln Val Ile Met Gln Ala Cys Cys Asp Val Leu Asn Arg Pro Leu
465                 470                 475                 480 
Gln Ile Val Ala Ser Asp Gln Cys Cys Ala Leu Gly Ala Ala Ile Phe
                485                 490                 495     
Ala Ala Val Ala Ala Lys Val His Ala Asp Ile Pro Ser Ala Gln Gln
            500                 505                 510         
Lys Met Ala Ser Ala Val Glu Lys Thr Leu Gln Pro Arg Ser Glu Gln
        515                 520                 525             
Ala Gln Arg Phe Glu Gln Leu Tyr Arg Arg Tyr Gln Gln Trp Ala Met
    530                 535                 540                 
Ser Ala Glu Gln His Tyr Leu Pro Thr Ser Ala Pro Ala Gln Ala Ala
545                 550                 555                 560 
Gln Ala Val Ala Thr Leu
                565     


<210> 229
<211> 1726
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in E. coli

<220> 
<221> CDS            
<222> (15)...(1712)

<400> 229
gaatactcca tatg atg gct atc gcg atc ggt ctg gac ttc ggt tct gac   50
                Met Ala Ile Ala Ile Gly Leu Asp Phe Gly Ser Asp
                 1               5                   10
 
tct gtt cgt gct ctg gct gtt gac tgc gcg tct ggt gaa gaa att gcg   98
Ser Val Arg Ala Leu Ala Val Asp Cys Ala Ser Gly Glu Glu Ile Ala
         15                  20                  25
 
acc tct gtt gaa tgg tat ccg cgt tgg cag aaa ggt cag ttt tgc gac   146
Thr Ser Val Glu Trp Tyr Pro Arg Trp Gln Lys Gly Gln Phe Cys Asp
     30                  35                  40
 
gct ccg aac aac cag ttt cgt cac cac ccg cgt gac tac atc gaa tct   194
Ala Pro Asn Asn Gln Phe Arg His His Pro Arg Asp Tyr Ile Glu Ser
 45                  50                  55                  60
 
atg gaa gct gct ctg aaa acc gtg ctg gct gag ctg tct gtt gaa cag   242
Met Glu Ala Ala Leu Lys Thr Val Leu Ala Glu Leu Ser Val Glu Gln
                 65                  70                  75
 
cgt gcg gcg gtt gtt ggt atc ggt gtt gac tct acc ggt tct acc ccg   290
Arg Ala Ala Val Val Gly Ile Gly Val Asp Ser Thr Gly Ser Thr Pro
             80                  85                  90
 
gct ccg atc gat gcg gac ggt aat gtt ctg gct ctg cgt cca gaa ttt   338
Ala Pro Ile Asp Ala Asp Gly Asn Val Leu Ala Leu Arg Pro Glu Phe
         95                 100                 105
 
gcg gaa aac cca aac gct atg ttc gtt ctg tgg aaa gat cac acc gct   386
Ala Glu Asn Pro Asn Ala Met Phe Val Leu Trp Lys Asp His Thr Ala
    110                 115                 120
 
gtt gaa cgt tct gaa gaa atc acc cgt ctg tgc cac gct ccg ggc aat   434
Val Glu Arg Ser Glu Glu Ile Thr Arg Leu Cys His Ala Pro Gly Asn
125                 130                 135                 140
 
gtt gac tac tct cgt tac atc ggt ggt atc tac tct tct gaa tgg ttt   482
Val Asp Tyr Ser Arg Tyr Ile Gly Gly Ile Tyr Ser Ser Glu Trp Phe
                145                 150                 155
 
tgg gcg aaa atc ctg cat gtt acc cgt caa gat tct gcg gtt gct cag   530
Trp Ala Lys Ile Leu His Val Thr Arg Gln Asp Ser Ala Val Ala Gln
            160                 165                 170
 
tct gct gct tct tgg atc gaa ctg tgc gat tgg gtt ccg gct ctg ctg   578
Ser Ala Ala Ser Trp Ile Glu Leu Cys Asp Trp Val Pro Ala Leu Leu
        175                 180                 185
 
tct ggt act acc cgt ccg caa gac atc cgt cgt ggt cgt tgc tct gcg   626
Ser Gly Thr Thr Arg Pro Gln Asp Ile Arg Arg Gly Arg Cys Ser Ala
    190                 195                 200
 
ggt cac aaa tct ctc tgg cat gaa tcc tgg ggt ggt ttg cct ccg gcg   674
Gly His Lys Ser Leu Trp His Glu Ser Trp Gly Gly Leu Pro Pro Ala
205                 210                 215                 220
 
tcc ttc ttc gac gaa ctg gac ccg atc ctg aac cgt cac ctg ccg tct   722
Ser Phe Phe Asp Glu Leu Asp Pro Ile Leu Asn Arg His Leu Pro Ser
                225                 230                 235
 
ccg ctg ttc acc gac act tgg act gcg gac atc ccg gtt ggc acc ctc   770
Pro Leu Phe Thr Asp Thr Trp Thr Ala Asp Ile Pro Val Gly Thr Leu
            240                 245                 250
 
tgt cca gag tgg gca cag cgc ctg ggt ctc ccg gag tct gtt gtt atc   818
Cys Pro Glu Trp Ala Gln Arg Leu Gly Leu Pro Glu Ser Val Val Ile
        255                 260                 265
 
agc ggt ggt gct ttt gac tgc cac atg ggt gcg gtt ggt gca ggt gct   866
Ser Gly Gly Ala Phe Asp Cys His Met Gly Ala Val Gly Ala Gly Ala
    270                 275                 280
 
cag cca aat gcg ctc gtt aaa gtt atc ggt act tct acc tgc gac atc   914
Gln Pro Asn Ala Leu Val Lys Val Ile Gly Thr Ser Thr Cys Asp Ile
285                 290                 295                 300
 
ctg atc gcg gac aaa cag tct gtt ggt gag cgt gcg gtt aaa ggt atc   962
Leu Ile Ala Asp Lys Gln Ser Val Gly Glu Arg Ala Val Lys Gly Ile
                305                 310                 315
 
tgc ggt cag gtt gac ggt tct gtt gtt ccg ggt ttc att ggt ctg gag   1010
Cys Gly Gln Val Asp Gly Ser Val Val Pro Gly Phe Ile Gly Leu Glu
            320                 325                 330
 
gct ggt cag tct gct ttc ggt gac atc tac gcg tgg ttc ggt cgt gtt   1058
Ala Gly Gln Ser Ala Phe Gly Asp Ile Tyr Ala Trp Phe Gly Arg Val
        335                 340                 345
 
ctg tct tgg ccg ctc gaa cag ctc gca gcg cag cat ccg gaa ctg aaa   1106
Leu Ser Trp Pro Leu Glu Gln Leu Ala Ala Gln His Pro Glu Leu Lys
    350                 355                 360
 
gct cag atc aac gcg tct cag aaa cag ctg ctg cct gcg ctc acc gag   1154
Ala Gln Ile Asn Ala Ser Gln Lys Gln Leu Leu Pro Ala Leu Thr Glu
365                 370                 375                 380
 
gcg tgg gct aaa aac ccg tct ctg gac cac ctg ccg gtt gtt ctg gat   1202
Ala Trp Ala Lys Asn Pro Ser Leu Asp His Leu Pro Val Val Leu Asp
                385                 390                 395
 
tgg ttc aat ggt cgt cgt tct ccg aat gcg aac cag cgt ctg aaa ggt   1250
Trp Phe Asn Gly Arg Arg Ser Pro Asn Ala Asn Gln Arg Leu Lys Gly
            400                 405                 410
 
gtt atc acc gac ctg aac ctg gct act gac gct ccg ctc ctg ttc ggt   1298
Val Ile Thr Asp Leu Asn Leu Ala Thr Asp Ala Pro Leu Leu Phe Gly
        415                 420                 425
 
ggt ctc atc gcg gct act gca ttc ggc gct cgt gct atc atg gaa tgc   1346
Gly Leu Ile Ala Ala Thr Ala Phe Gly Ala Arg Ala Ile Met Glu Cys
    430                 435                 440
 
ttt acc gac caa ggc atc gcg gtt aac aac gtt atg gct ctg ggt ggt   1394
Phe Thr Asp Gln Gly Ile Ala Val Asn Asn Val Met Ala Leu Gly Gly
445                 450                 455                 460
 
att gcg cgt aaa aac cag gtt atc atg caa gcg tgc tgc gac gtt ctg   1442
Ile Ala Arg Lys Asn Gln Val Ile Met Gln Ala Cys Cys Asp Val Leu
                465                 470                 475
 
aac cgc ccg ctc cag att gtt gcg tct gac cag tgt tgt gcg ttg ggt   1490
Asn Arg Pro Leu Gln Ile Val Ala Ser Asp Gln Cys Cys Ala Leu Gly
            480                 485                 490
 
gct gct att ttt gcg gct gtt gca gct aag gtt cac gct gat att ccg   1538
Ala Ala Ile Phe Ala Ala Val Ala Ala Lys Val His Ala Asp Ile Pro
        495                 500                 505
 
agc gca cag cag aaa atg gct tct gcg gtt gaa aag acc ctc cag cca   1586
Ser Ala Gln Gln Lys Met Ala Ser Ala Val Glu Lys Thr Leu Gln Pro
    510                 515                 520
 
cgt tct gaa caa gcg cag cgt ttc gaa cag ctg tac cgt cgt tac cag   1634
Arg Ser Glu Gln Ala Gln Arg Phe Glu Gln Leu Tyr Arg Arg Tyr Gln
525                 530                 535                 540
 
cag tgg gct atg tct gcg gaa cag cac tac ctc ccg act agc gct cct   1682
Gln Trp Ala Met Ser Ala Glu Gln His Tyr Leu Pro Thr Ser Ala Pro
                545                 550                 555
 
gct caa gcg gcc caa gca gtt gcg acc ctg actagtcgat gcct           1726
Ala Gln Ala Ala Gln Ala Val Ala Thr Leu
            560                 565
 

<210> 230
<211> 566
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in E. coli

<400> 230
Met Ala Ile Ala Ile Gly Leu Asp Phe Gly Ser Asp Ser Val Arg Ala
 1               5                  10                  15      
Leu Ala Val Asp Cys Ala Ser Gly Glu Glu Ile Ala Thr Ser Val Glu
            20                  25                  30          
Trp Tyr Pro Arg Trp Gln Lys Gly Gln Phe Cys Asp Ala Pro Asn Asn
        35                  40                  45              
Gln Phe Arg His His Pro Arg Asp Tyr Ile Glu Ser Met Glu Ala Ala
    50                  55                  60                  
Leu Lys Thr Val Leu Ala Glu Leu Ser Val Glu Gln Arg Ala Ala Val
65                  70                  75                  80  
Val Gly Ile Gly Val Asp Ser Thr Gly Ser Thr Pro Ala Pro Ile Asp
                85                  90                  95      
Ala Asp Gly Asn Val Leu Ala Leu Arg Pro Glu Phe Ala Glu Asn Pro
            100                 105                 110         
Asn Ala Met Phe Val Leu Trp Lys Asp His Thr Ala Val Glu Arg Ser
        115                 120                 125             
Glu Glu Ile Thr Arg Leu Cys His Ala Pro Gly Asn Val Asp Tyr Ser
    130                 135                 140                 
Arg Tyr Ile Gly Gly Ile Tyr Ser Ser Glu Trp Phe Trp Ala Lys Ile
145                 150                 155                 160 
Leu His Val Thr Arg Gln Asp Ser Ala Val Ala Gln Ser Ala Ala Ser
                165                 170                 175     
Trp Ile Glu Leu Cys Asp Trp Val Pro Ala Leu Leu Ser Gly Thr Thr
            180                 185                 190         
Arg Pro Gln Asp Ile Arg Arg Gly Arg Cys Ser Ala Gly His Lys Ser
        195                 200                 205             
Leu Trp His Glu Ser Trp Gly Gly Leu Pro Pro Ala Ser Phe Phe Asp
    210                 215                 220                 
Glu Leu Asp Pro Ile Leu Asn Arg His Leu Pro Ser Pro Leu Phe Thr
225                 230                 235                 240 
Asp Thr Trp Thr Ala Asp Ile Pro Val Gly Thr Leu Cys Pro Glu Trp
                245                 250                 255     
Ala Gln Arg Leu Gly Leu Pro Glu Ser Val Val Ile Ser Gly Gly Ala
            260                 265                 270         
Phe Asp Cys His Met Gly Ala Val Gly Ala Gly Ala Gln Pro Asn Ala
        275                 280                 285             
Leu Val Lys Val Ile Gly Thr Ser Thr Cys Asp Ile Leu Ile Ala Asp
    290                 295                 300                 
Lys Gln Ser Val Gly Glu Arg Ala Val Lys Gly Ile Cys Gly Gln Val
305                 310                 315                 320 
Asp Gly Ser Val Val Pro Gly Phe Ile Gly Leu Glu Ala Gly Gln Ser
                325                 330                 335     
Ala Phe Gly Asp Ile Tyr Ala Trp Phe Gly Arg Val Leu Ser Trp Pro
            340                 345                 350         
Leu Glu Gln Leu Ala Ala Gln His Pro Glu Leu Lys Ala Gln Ile Asn
        355                 360                 365             
Ala Ser Gln Lys Gln Leu Leu Pro Ala Leu Thr Glu Ala Trp Ala Lys
    370                 375                 380                 
Asn Pro Ser Leu Asp His Leu Pro Val Val Leu Asp Trp Phe Asn Gly
385                 390                 395                 400 
Arg Arg Ser Pro Asn Ala Asn Gln Arg Leu Lys Gly Val Ile Thr Asp
                405                 410                 415     
Leu Asn Leu Ala Thr Asp Ala Pro Leu Leu Phe Gly Gly Leu Ile Ala
            420                 425                 430         
Ala Thr Ala Phe Gly Ala Arg Ala Ile Met Glu Cys Phe Thr Asp Gln
        435                 440                 445             
Gly Ile Ala Val Asn Asn Val Met Ala Leu Gly Gly Ile Ala Arg Lys
    450                 455                 460                 
Asn Gln Val Ile Met Gln Ala Cys Cys Asp Val Leu Asn Arg Pro Leu
465                 470                 475                 480 
Gln Ile Val Ala Ser Asp Gln Cys Cys Ala Leu Gly Ala Ala Ile Phe
                485                 490                 495     
Ala Ala Val Ala Ala Lys Val His Ala Asp Ile Pro Ser Ala Gln Gln
            500                 505                 510         
Lys Met Ala Ser Ala Val Glu Lys Thr Leu Gln Pro Arg Ser Glu Gln
        515                 520                 525             
Ala Gln Arg Phe Glu Gln Leu Tyr Arg Arg Tyr Gln Gln Trp Ala Met
    530                 535                 540                 
Ser Ala Glu Gln His Tyr Leu Pro Thr Ser Ala Pro Ala Gln Ala Ala
545                 550                 555                 560 
Gln Ala Val Ala Thr Leu
                565     


<210> 231
<211> 1698
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in P. pastoris

<220> 
<221> CDS            
<222> (1)...(1698)

<400> 231
atg gct att gct att gga ttg gac ttt ggt tct gat tct gtt aga gct   48
Met Ala Ile Ala Ile Gly Leu Asp Phe Gly Ser Asp Ser Val Arg Ala
 1               5                   10                  15
 
ttg gct gtt gat tgt gct tct gga gaa gaa att gct act tct gtt gaa   96
Leu Ala Val Asp Cys Ala Ser Gly Glu Glu Ile Ala Thr Ser Val Glu
             20                  25                  30
 
tgg tat cct aga tgg caa aaa gga caa ttt tgt gat gct cca aat aat   144
Trp Tyr Pro Arg Trp Gln Lys Gly Gln Phe Cys Asp Ala Pro Asn Asn
         35                  40                  45
 
caa ttt aga cat cat cct aga gat tat att gaa tct atg gaa gct gct   192
Gln Phe Arg His His Pro Arg Asp Tyr Ile Glu Ser Met Glu Ala Ala
     50                  55                  60
 
tta aaa act gtt ttg gct gaa ttg tct gtt gaa caa aga gct gcc gtt   240
Leu Lys Thr Val Leu Ala Glu Leu Ser Val Glu Gln Arg Ala Ala Val
 65                  70                  75                  80
 
gtt gga att gga gtt gat tct act gga tct act cct gct cca att gat   288
Val Gly Ile Gly Val Asp Ser Thr Gly Ser Thr Pro Ala Pro Ile Asp
                 85                  90                  95
 
gct gat gga aat gtg ttg gct ttg aga cca gaa ttt gca gaa aat cct   336
Ala Asp Gly Asn Val Leu Ala Leu Arg Pro Glu Phe Ala Glu Asn Pro
            100                 105                 110
 
aac gct atg ttt gtt ttg tgg aaa gat cat act gct gtt gaa aga tct   384
Asn Ala Met Phe Val Leu Trp Lys Asp His Thr Ala Val Glu Arg Ser
        115                 120                 125
 
gaa gaa att act aga ttg tgt cat gct cca gga aat gtt gat tat tct   432
Glu Glu Ile Thr Arg Leu Cys His Ala Pro Gly Asn Val Asp Tyr Ser
    130                 135                 140
 
aga tat att gga gga att tat tct tct gaa tgg ttt tgg gct aaa att   480
Arg Tyr Ile Gly Gly Ile Tyr Ser Ser Glu Trp Phe Trp Ala Lys Ile
145                 150                 155                 160
 
ttg cat gtt act aga caa gat tct gct gtg gct caa tct gct gct tct   528
Leu His Val Thr Arg Gln Asp Ser Ala Val Ala Gln Ser Ala Ala Ser
                165                 170                 175
 
tgg att gaa ttg tgt gat tgg gtt cca gct tta ttg agt gga aca act   576
Trp Ile Glu Leu Cys Asp Trp Val Pro Ala Leu Leu Ser Gly Thr Thr
            180                 185                 190
 
aga cca caa gac att aga aga ggt aga tgt tct gct ggg cat aaa tca   624
Arg Pro Gln Asp Ile Arg Arg Gly Arg Cys Ser Ala Gly His Lys Ser
        195                 200                 205
 
ttg tgg cat gaa tct tgg ggt ggt ttg cct cct gct tca ttc ttt gat   672
Leu Trp His Glu Ser Trp Gly Gly Leu Pro Pro Ala Ser Phe Phe Asp
    210                 215                 220
 
gaa ttg gac cca att tta aat aga cat ttg cca tct cca ttg ttt act   720
Glu Leu Asp Pro Ile Leu Asn Arg His Leu Pro Ser Pro Leu Phe Thr
225                 230                 235                 240
 
gat act tgg act gct gat ata cca gtt ggt act tta tgt cca gaa tgg   768
Asp Thr Trp Thr Ala Asp Ile Pro Val Gly Thr Leu Cys Pro Glu Trp
                245                 250                 255
 
gct caa aga ttg gga ttg cca gaa tct gtt gtt att tca gga gga gct   816
Ala Gln Arg Leu Gly Leu Pro Glu Ser Val Val Ile Ser Gly Gly Ala
            260                 265                 270
 
ttt gat tgt cac atg gga gct gtt ggt gct ggc gct caa cct aat gca   864
Phe Asp Cys His Met Gly Ala Val Gly Ala Gly Ala Gln Pro Asn Ala
        275                 280                 285
 
ttg gtt aaa gtt att gga aca tct act tgt gac att ttg att gct gat   912
Leu Val Lys Val Ile Gly Thr Ser Thr Cys Asp Ile Leu Ile Ala Asp
    290                 295                 300
 
aaa caa tct gtt gga gaa aga gct gtt aaa gga att tgt gga caa gtt   960
Lys Gln Ser Val Gly Glu Arg Ala Val Lys Gly Ile Cys Gly Gln Val
305                 310                 315                 320
 
gat gga tct gtt gtt cca gga ttt att gga tta gaa gct gga caa tct   1008
Asp Gly Ser Val Val Pro Gly Phe Ile Gly Leu Glu Ala Gly Gln Ser
                325                 330                 335
 
gct ttt ggt gac att tat gct tgg ttt ggt aga gtt ttg tct tgg cca   1056
Ala Phe Gly Asp Ile Tyr Ala Trp Phe Gly Arg Val Leu Ser Trp Pro
            340                 345                 350
 
tta gaa caa ctc gct gct caa cat cca gaa tta aaa gct caa att aac   1104
Leu Glu Gln Leu Ala Ala Gln His Pro Glu Leu Lys Ala Gln Ile Asn
        355                 360                 365
 
gct tct caa aaa caa ttg ttg cca gct ttg act gaa gca tgg gct aaa   1152
Ala Ser Gln Lys Gln Leu Leu Pro Ala Leu Thr Glu Ala Trp Ala Lys
    370                 375                 380
 
aat cca tct tta gat cat ttg cca gtt gtt ttg gat tgg ttt aat ggt   1200
Asn Pro Ser Leu Asp His Leu Pro Val Val Leu Asp Trp Phe Asn Gly
385                 390                 395                 400
 
aga aga tct cca aat gca aat caa aga tta aaa gga gtt att act gat   1248
Arg Arg Ser Pro Asn Ala Asn Gln Arg Leu Lys Gly Val Ile Thr Asp
                405                 410                 415
 
tta aat ttg gct act gat gct cca ttg ttg ttt ggt gga ttg att gct   1296
Leu Asn Leu Ala Thr Asp Ala Pro Leu Leu Phe Gly Gly Leu Ile Ala
            420                 425                 430
 
gct act gct ttt ggt gct aga gct att atg gaa tgt ttt act gat cag   1344
Ala Thr Ala Phe Gly Ala Arg Ala Ile Met Glu Cys Phe Thr Asp Gln
        435                 440                 445
 
gga att gct gtt aat aat gtt atg gct ttg gga gga att gca agg aaa   1392
Gly Ile Ala Val Asn Asn Val Met Ala Leu Gly Gly Ile Ala Arg Lys
    450                 455                 460
 
aat caa gtt att atg cag gct tgt tgt gac gtt tta aat aga cca ttg   1440
Asn Gln Val Ile Met Gln Ala Cys Cys Asp Val Leu Asn Arg Pro Leu
465                 470                 475                 480
 
caa att gta gct tct gat caa tgt tgt gct tta gga gct gct att ttc   1488
Gln Ile Val Ala Ser Asp Gln Cys Cys Ala Leu Gly Ala Ala Ile Phe
                485                 490                 495
 
gct gcc gta gct gca aaa gtt cat gcc gat ata cca tct gct caa cag   1536
Ala Ala Val Ala Ala Lys Val His Ala Asp Ile Pro Ser Ala Gln Gln
            500                 505                 510
 
aaa atg gct tcg gct gta gaa aag aca ttg caa cct aga tct gaa caa   1584
Lys Met Ala Ser Ala Val Glu Lys Thr Leu Gln Pro Arg Ser Glu Gln
        515                 520                 525
 
gca caa aga ttt gag caa ttg tat aga aga tat caa caa tgg gct atg   1632
Ala Gln Arg Phe Glu Gln Leu Tyr Arg Arg Tyr Gln Gln Trp Ala Met
    530                 535                 540
 
agt gct gaa caa cat tat ttg cca act tct gca cct gct cag gct gca   1680
Ser Ala Glu Gln His Tyr Leu Pro Thr Ser Ala Pro Ala Gln Ala Ala
545                 550                 555                 560
 
caa gct gta gct act tta                                           1698
Gln Ala Val Ala Thr Leu
                565
 

<210> 232
<211> 566
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in P. pastoris

<400> 232
Met Ala Ile Ala Ile Gly Leu Asp Phe Gly Ser Asp Ser Val Arg Ala
 1               5                  10                  15      
Leu Ala Val Asp Cys Ala Ser Gly Glu Glu Ile Ala Thr Ser Val Glu
            20                  25                  30          
Trp Tyr Pro Arg Trp Gln Lys Gly Gln Phe Cys Asp Ala Pro Asn Asn
        35                  40                  45              
Gln Phe Arg His His Pro Arg Asp Tyr Ile Glu Ser Met Glu Ala Ala
    50                  55                  60                  
Leu Lys Thr Val Leu Ala Glu Leu Ser Val Glu Gln Arg Ala Ala Val
65                  70                  75                  80  
Val Gly Ile Gly Val Asp Ser Thr Gly Ser Thr Pro Ala Pro Ile Asp
                85                  90                  95      
Ala Asp Gly Asn Val Leu Ala Leu Arg Pro Glu Phe Ala Glu Asn Pro
            100                 105                 110         
Asn Ala Met Phe Val Leu Trp Lys Asp His Thr Ala Val Glu Arg Ser
        115                 120                 125             
Glu Glu Ile Thr Arg Leu Cys His Ala Pro Gly Asn Val Asp Tyr Ser
    130                 135                 140                 
Arg Tyr Ile Gly Gly Ile Tyr Ser Ser Glu Trp Phe Trp Ala Lys Ile
145                 150                 155                 160 
Leu His Val Thr Arg Gln Asp Ser Ala Val Ala Gln Ser Ala Ala Ser
                165                 170                 175     
Trp Ile Glu Leu Cys Asp Trp Val Pro Ala Leu Leu Ser Gly Thr Thr
            180                 185                 190         
Arg Pro Gln Asp Ile Arg Arg Gly Arg Cys Ser Ala Gly His Lys Ser
        195                 200                 205             
Leu Trp His Glu Ser Trp Gly Gly Leu Pro Pro Ala Ser Phe Phe Asp
    210                 215                 220                 
Glu Leu Asp Pro Ile Leu Asn Arg His Leu Pro Ser Pro Leu Phe Thr
225                 230                 235                 240 
Asp Thr Trp Thr Ala Asp Ile Pro Val Gly Thr Leu Cys Pro Glu Trp
                245                 250                 255     
Ala Gln Arg Leu Gly Leu Pro Glu Ser Val Val Ile Ser Gly Gly Ala
            260                 265                 270         
Phe Asp Cys His Met Gly Ala Val Gly Ala Gly Ala Gln Pro Asn Ala
        275                 280                 285             
Leu Val Lys Val Ile Gly Thr Ser Thr Cys Asp Ile Leu Ile Ala Asp
    290                 295                 300                 
Lys Gln Ser Val Gly Glu Arg Ala Val Lys Gly Ile Cys Gly Gln Val
305                 310                 315                 320 
Asp Gly Ser Val Val Pro Gly Phe Ile Gly Leu Glu Ala Gly Gln Ser
                325                 330                 335     
Ala Phe Gly Asp Ile Tyr Ala Trp Phe Gly Arg Val Leu Ser Trp Pro
            340                 345                 350         
Leu Glu Gln Leu Ala Ala Gln His Pro Glu Leu Lys Ala Gln Ile Asn
        355                 360                 365             
Ala Ser Gln Lys Gln Leu Leu Pro Ala Leu Thr Glu Ala Trp Ala Lys
    370                 375                 380                 
Asn Pro Ser Leu Asp His Leu Pro Val Val Leu Asp Trp Phe Asn Gly
385                 390                 395                 400 
Arg Arg Ser Pro Asn Ala Asn Gln Arg Leu Lys Gly Val Ile Thr Asp
                405                 410                 415     
Leu Asn Leu Ala Thr Asp Ala Pro Leu Leu Phe Gly Gly Leu Ile Ala
            420                 425                 430         
Ala Thr Ala Phe Gly Ala Arg Ala Ile Met Glu Cys Phe Thr Asp Gln
        435                 440                 445             
Gly Ile Ala Val Asn Asn Val Met Ala Leu Gly Gly Ile Ala Arg Lys
    450                 455                 460                 
Asn Gln Val Ile Met Gln Ala Cys Cys Asp Val Leu Asn Arg Pro Leu
465                 470                 475                 480 
Gln Ile Val Ala Ser Asp Gln Cys Cys Ala Leu Gly Ala Ala Ile Phe
                485                 490                 495     
Ala Ala Val Ala Ala Lys Val His Ala Asp Ile Pro Ser Ala Gln Gln
            500                 505                 510         
Lys Met Ala Ser Ala Val Glu Lys Thr Leu Gln Pro Arg Ser Glu Gln
        515                 520                 525             
Ala Gln Arg Phe Glu Gln Leu Tyr Arg Arg Tyr Gln Gln Trp Ala Met
    530                 535                 540                 
Ser Ala Glu Gln His Tyr Leu Pro Thr Ser Ala Pro Ala Gln Ala Ala
545                 550                 555                 560 
Gln Ala Val Ala Thr Leu
                565     


<210> 233
<211> 1726
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in P. pastoris

<220> 
<221> CDS            
<222> (15)...(1712)

<400> 233
gaatactcca tatg atg gct att gct att gga ttg gac ttt ggt tct gat   50
                Met Ala Ile Ala Ile Gly Leu Asp Phe Gly Ser Asp
                 1               5                   10
 
tct gtt aga gct ttg gct gtt gat tgt gct tct gga gaa gaa att gct   98
Ser Val Arg Ala Leu Ala Val Asp Cys Ala Ser Gly Glu Glu Ile Ala
         15                  20                  25
 
act tct gtt gaa tgg tat cct aga tgg caa aaa gga caa ttt tgt gat   146
Thr Ser Val Glu Trp Tyr Pro Arg Trp Gln Lys Gly Gln Phe Cys Asp
     30                  35                  40
 
gct cca aat aat caa ttt aga cat cat cct aga gat tat att gaa tct   194
Ala Pro Asn Asn Gln Phe Arg His His Pro Arg Asp Tyr Ile Glu Ser
 45                  50                  55                  60
 
atg gaa gct gct tta aaa act gtt ttg gct gaa ttg tct gtt gaa caa   242
Met Glu Ala Ala Leu Lys Thr Val Leu Ala Glu Leu Ser Val Glu Gln
                 65                  70                  75
 
aga gct gcc gtt gtt gga att gga gtt gat tct act gga tct act cct   290
Arg Ala Ala Val Val Gly Ile Gly Val Asp Ser Thr Gly Ser Thr Pro
             80                  85                  90
 
gct cca att gat gct gat gga aat gtg ttg gct ttg aga cca gaa ttt   338
Ala Pro Ile Asp Ala Asp Gly Asn Val Leu Ala Leu Arg Pro Glu Phe
         95                 100                 105
 
gca gaa aat cct aac gct atg ttt gtt ttg tgg aaa gat cat act gct   386
Ala Glu Asn Pro Asn Ala Met Phe Val Leu Trp Lys Asp His Thr Ala
    110                 115                 120
 
gtt gaa aga tct gaa gaa att act aga ttg tgt cat gct cca gga aat   434
Val Glu Arg Ser Glu Glu Ile Thr Arg Leu Cys His Ala Pro Gly Asn
125                 130                 135                 140
 
gtt gat tat tct aga tat att gga gga att tat tct tct gaa tgg ttt   482
Val Asp Tyr Ser Arg Tyr Ile Gly Gly Ile Tyr Ser Ser Glu Trp Phe
                145                 150                 155
 
tgg gct aaa att ttg cat gtt act aga caa gat tct gct gtg gct caa   530
Trp Ala Lys Ile Leu His Val Thr Arg Gln Asp Ser Ala Val Ala Gln
            160                 165                 170
 
tct gct gct tct tgg att gaa ttg tgt gat tgg gtt cca gct tta ttg   578
Ser Ala Ala Ser Trp Ile Glu Leu Cys Asp Trp Val Pro Ala Leu Leu
        175                 180                 185
 
agt gga aca act aga cca caa gac att aga aga ggt aga tgt tct gct   626
Ser Gly Thr Thr Arg Pro Gln Asp Ile Arg Arg Gly Arg Cys Ser Ala
    190                 195                 200
 
ggg cat aaa tca ttg tgg cat gaa tct tgg ggt ggt ttg cct cct gct   674
Gly His Lys Ser Leu Trp His Glu Ser Trp Gly Gly Leu Pro Pro Ala
205                 210                 215                 220
 
tca ttc ttt gat gaa ttg gac cca att tta aat aga cat ttg cca tct   722
Ser Phe Phe Asp Glu Leu Asp Pro Ile Leu Asn Arg His Leu Pro Ser
                225                 230                 235
 
cca ttg ttt act gat act tgg act gct gat ata cca gtt ggt act tta   770
Pro Leu Phe Thr Asp Thr Trp Thr Ala Asp Ile Pro Val Gly Thr Leu
            240                 245                 250
 
tgt cca gaa tgg gct caa aga ttg gga ttg cca gaa tct gtt gtt att   818
Cys Pro Glu Trp Ala Gln Arg Leu Gly Leu Pro Glu Ser Val Val Ile
        255                 260                 265
 
tca gga gga gct ttt gat tgt cac atg gga gct gtt ggt gct ggc gct   866
Ser Gly Gly Ala Phe Asp Cys His Met Gly Ala Val Gly Ala Gly Ala
    270                 275                 280
 
caa cct aat gca ttg gtt aaa gtt att gga aca tct act tgt gac att   914
Gln Pro Asn Ala Leu Val Lys Val Ile Gly Thr Ser Thr Cys Asp Ile
285                 290                 295                 300
 
ttg att gct gat aaa caa tct gtt gga gaa aga gct gtt aaa gga att   962
Leu Ile Ala Asp Lys Gln Ser Val Gly Glu Arg Ala Val Lys Gly Ile
                305                 310                 315
 
tgt gga caa gtt gat gga tct gtt gtt cca gga ttt att gga tta gaa   1010
Cys Gly Gln Val Asp Gly Ser Val Val Pro Gly Phe Ile Gly Leu Glu
            320                 325                 330
 
gct gga caa tct gct ttt ggt gac att tat gct tgg ttt ggt aga gtt   1058
Ala Gly Gln Ser Ala Phe Gly Asp Ile Tyr Ala Trp Phe Gly Arg Val
        335                 340                 345
 
ttg tct tgg cca tta gaa caa ctc gct gct caa cat cca gaa tta aaa   1106
Leu Ser Trp Pro Leu Glu Gln Leu Ala Ala Gln His Pro Glu Leu Lys
    350                 355                 360
 
gct caa att aac gct tct caa aaa caa ttg ttg cca gct ttg act gaa   1154
Ala Gln Ile Asn Ala Ser Gln Lys Gln Leu Leu Pro Ala Leu Thr Glu
365                 370                 375                 380
 
gca tgg gct aaa aat cca tct tta gat cat ttg cca gtt gtt ttg gat   1202
Ala Trp Ala Lys Asn Pro Ser Leu Asp His Leu Pro Val Val Leu Asp
                385                 390                 395
 
tgg ttt aat ggt aga aga tct cca aat gca aat caa aga tta aaa gga   1250
Trp Phe Asn Gly Arg Arg Ser Pro Asn Ala Asn Gln Arg Leu Lys Gly
            400                 405                 410
 
gtt att act gat tta aat ttg gct act gat gct cca ttg ttg ttt ggt   1298
Val Ile Thr Asp Leu Asn Leu Ala Thr Asp Ala Pro Leu Leu Phe Gly
        415                 420                 425
 
gga ttg att gct gct act gct ttt ggt gct aga gct att atg gaa tgt   1346
Gly Leu Ile Ala Ala Thr Ala Phe Gly Ala Arg Ala Ile Met Glu Cys
    430                 435                 440
 
ttt act gat cag gga att gct gtt aat aat gtt atg gct ttg gga gga   1394
Phe Thr Asp Gln Gly Ile Ala Val Asn Asn Val Met Ala Leu Gly Gly
445                 450                 455                 460
 
att gca agg aaa aat caa gtt att atg cag gct tgt tgt gac gtt tta   1442
Ile Ala Arg Lys Asn Gln Val Ile Met Gln Ala Cys Cys Asp Val Leu
                465                 470                 475
 
aat aga cca ttg caa att gta gct tct gat caa tgt tgt gct tta gga   1490
Asn Arg Pro Leu Gln Ile Val Ala Ser Asp Gln Cys Cys Ala Leu Gly
            480                 485                 490
 
gct gct att ttc gct gcc gta gct gca aaa gtt cat gcc gat ata cca   1538
Ala Ala Ile Phe Ala Ala Val Ala Ala Lys Val His Ala Asp Ile Pro
        495                 500                 505
 
tct gct caa cag aaa atg gct tcg gct gta gaa aag aca ttg caa cct   1586
Ser Ala Gln Gln Lys Met Ala Ser Ala Val Glu Lys Thr Leu Gln Pro
    510                 515                 520
 
aga tct gaa caa gca caa aga ttt gag caa ttg tat aga aga tat caa   1634
Arg Ser Glu Gln Ala Gln Arg Phe Glu Gln Leu Tyr Arg Arg Tyr Gln
525                 530                 535                 540
 
caa tgg gct atg agt gct gaa caa cat tat ttg cca act tct gca cct   1682
Gln Trp Ala Met Ser Ala Glu Gln His Tyr Leu Pro Thr Ser Ala Pro
                545                 550                 555
 
gct cag gct gca caa gct gta gct act tta actagtcgat gcct           1726
Ala Gln Ala Ala Gln Ala Val Ala Thr Leu
            560                 565
 

<210> 234
<211> 566
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in P. pastoris

<400> 234
Met Ala Ile Ala Ile Gly Leu Asp Phe Gly Ser Asp Ser Val Arg Ala
 1               5                  10                  15      
Leu Ala Val Asp Cys Ala Ser Gly Glu Glu Ile Ala Thr Ser Val Glu
            20                  25                  30          
Trp Tyr Pro Arg Trp Gln Lys Gly Gln Phe Cys Asp Ala Pro Asn Asn
        35                  40                  45              
Gln Phe Arg His His Pro Arg Asp Tyr Ile Glu Ser Met Glu Ala Ala
    50                  55                  60                  
Leu Lys Thr Val Leu Ala Glu Leu Ser Val Glu Gln Arg Ala Ala Val
65                  70                  75                  80  
Val Gly Ile Gly Val Asp Ser Thr Gly Ser Thr Pro Ala Pro Ile Asp
                85                  90                  95      
Ala Asp Gly Asn Val Leu Ala Leu Arg Pro Glu Phe Ala Glu Asn Pro
            100                 105                 110         
Asn Ala Met Phe Val Leu Trp Lys Asp His Thr Ala Val Glu Arg Ser
        115                 120                 125             
Glu Glu Ile Thr Arg Leu Cys His Ala Pro Gly Asn Val Asp Tyr Ser
    130                 135                 140                 
Arg Tyr Ile Gly Gly Ile Tyr Ser Ser Glu Trp Phe Trp Ala Lys Ile
145                 150                 155                 160 
Leu His Val Thr Arg Gln Asp Ser Ala Val Ala Gln Ser Ala Ala Ser
                165                 170                 175     
Trp Ile Glu Leu Cys Asp Trp Val Pro Ala Leu Leu Ser Gly Thr Thr
            180                 185                 190         
Arg Pro Gln Asp Ile Arg Arg Gly Arg Cys Ser Ala Gly His Lys Ser
        195                 200                 205             
Leu Trp His Glu Ser Trp Gly Gly Leu Pro Pro Ala Ser Phe Phe Asp
    210                 215                 220                 
Glu Leu Asp Pro Ile Leu Asn Arg His Leu Pro Ser Pro Leu Phe Thr
225                 230                 235                 240 
Asp Thr Trp Thr Ala Asp Ile Pro Val Gly Thr Leu Cys Pro Glu Trp
                245                 250                 255     
Ala Gln Arg Leu Gly Leu Pro Glu Ser Val Val Ile Ser Gly Gly Ala
            260                 265                 270         
Phe Asp Cys His Met Gly Ala Val Gly Ala Gly Ala Gln Pro Asn Ala
        275                 280                 285             
Leu Val Lys Val Ile Gly Thr Ser Thr Cys Asp Ile Leu Ile Ala Asp
    290                 295                 300                 
Lys Gln Ser Val Gly Glu Arg Ala Val Lys Gly Ile Cys Gly Gln Val
305                 310                 315                 320 
Asp Gly Ser Val Val Pro Gly Phe Ile Gly Leu Glu Ala Gly Gln Ser
                325                 330                 335     
Ala Phe Gly Asp Ile Tyr Ala Trp Phe Gly Arg Val Leu Ser Trp Pro
            340                 345                 350         
Leu Glu Gln Leu Ala Ala Gln His Pro Glu Leu Lys Ala Gln Ile Asn
        355                 360                 365             
Ala Ser Gln Lys Gln Leu Leu Pro Ala Leu Thr Glu Ala Trp Ala Lys
    370                 375                 380                 
Asn Pro Ser Leu Asp His Leu Pro Val Val Leu Asp Trp Phe Asn Gly
385                 390                 395                 400 
Arg Arg Ser Pro Asn Ala Asn Gln Arg Leu Lys Gly Val Ile Thr Asp
                405                 410                 415     
Leu Asn Leu Ala Thr Asp Ala Pro Leu Leu Phe Gly Gly Leu Ile Ala
            420                 425                 430         
Ala Thr Ala Phe Gly Ala Arg Ala Ile Met Glu Cys Phe Thr Asp Gln
        435                 440                 445             
Gly Ile Ala Val Asn Asn Val Met Ala Leu Gly Gly Ile Ala Arg Lys
    450                 455                 460                 
Asn Gln Val Ile Met Gln Ala Cys Cys Asp Val Leu Asn Arg Pro Leu
465                 470                 475                 480 
Gln Ile Val Ala Ser Asp Gln Cys Cys Ala Leu Gly Ala Ala Ile Phe
                485                 490                 495     
Ala Ala Val Ala Ala Lys Val His Ala Asp Ile Pro Ser Ala Gln Gln
            500                 505                 510         
Lys Met Ala Ser Ala Val Glu Lys Thr Leu Gln Pro Arg Ser Glu Gln
        515                 520                 525             
Ala Gln Arg Phe Glu Gln Leu Tyr Arg Arg Tyr Gln Gln Trp Ala Met
    530                 535                 540                 
Ser Ala Glu Gln His Tyr Leu Pro Thr Ser Ala Pro Ala Gln Ala Ala
545                 550                 555                 560 
Gln Ala Val Ala Thr Leu
                565     


<210> 235
<211> 1720
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in P. pastoris

<220> 
<221> CDS            
<222> (12)...(1709)

<400> 235
tactcaagct t atg gct att gct att gga ttg gac ttt ggt tct gat tct  50
             Met Ala Ile Ala Ile Gly Leu Asp Phe Gly Ser Asp Ser
              1               5                   10
 
gtt aga gct ttg gct gtt gat tgt gct tct gga gaa gaa att gct act   98
Val Arg Ala Leu Ala Val Asp Cys Ala Ser Gly Glu Glu Ile Ala Thr
     15                  20                  25
 
tct gtt gaa tgg tat cct aga tgg caa aaa gga caa ttt tgt gat gct   146
Ser Val Glu Trp Tyr Pro Arg Trp Gln Lys Gly Gln Phe Cys Asp Ala
 30                  35                  40                  45
 
cca aat aat caa ttt aga cat cat cct aga gat tat att gaa tct atg   194
Pro Asn Asn Gln Phe Arg His His Pro Arg Asp Tyr Ile Glu Ser Met
                 50                  55                  60
 
gaa gct gct tta aaa act gtt ttg gct gaa ttg tct gtt gaa caa aga   242
Glu Ala Ala Leu Lys Thr Val Leu Ala Glu Leu Ser Val Glu Gln Arg
             65                  70                  75
 
gct gcc gtt gtt gga att gga gtt gat tct act gga tct act cct gct   290
Ala Ala Val Val Gly Ile Gly Val Asp Ser Thr Gly Ser Thr Pro Ala
         80                  85                  90
 
cca att gat gct gat gga aat gtg ttg gct ttg aga cca gaa ttt gca   338
Pro Ile Asp Ala Asp Gly Asn Val Leu Ala Leu Arg Pro Glu Phe Ala
     95                 100                 105
 
gaa aat cct aac gct atg ttt gtt ttg tgg aaa gat cat act gct gtt   386
Glu Asn Pro Asn Ala Met Phe Val Leu Trp Lys Asp His Thr Ala Val
110                 115                 120                 125
 
gaa aga tct gaa gaa att act aga ttg tgt cat gct cca gga aat gtt   434
Glu Arg Ser Glu Glu Ile Thr Arg Leu Cys His Ala Pro Gly Asn Val
                130                 135                 140
 
gat tat tct aga tat att gga gga att tat tct tct gaa tgg ttt tgg   482
Asp Tyr Ser Arg Tyr Ile Gly Gly Ile Tyr Ser Ser Glu Trp Phe Trp
            145                 150                 155
 
gct aaa att ttg cat gtt act aga caa gat tct gct gtg gct caa tct   530
Ala Lys Ile Leu His Val Thr Arg Gln Asp Ser Ala Val Ala Gln Ser
        160                 165                 170
 
gct gct tct tgg att gaa ttg tgt gat tgg gtt cca gct tta ttg agt   578
Ala Ala Ser Trp Ile Glu Leu Cys Asp Trp Val Pro Ala Leu Leu Ser
    175                 180                 185
 
gga aca act aga cca caa gac att aga aga ggt aga tgt tct gct ggg   626
Gly Thr Thr Arg Pro Gln Asp Ile Arg Arg Gly Arg Cys Ser Ala Gly
190                 195                 200                 205
 
cat aaa tca ttg tgg cat gaa tct tgg ggt ggt ttg cct cct gct tca   674
His Lys Ser Leu Trp His Glu Ser Trp Gly Gly Leu Pro Pro Ala Ser
                210                 215                 220
 
ttc ttt gat gaa ttg gac cca att tta aat aga cat ttg cca tct cca   722
Phe Phe Asp Glu Leu Asp Pro Ile Leu Asn Arg His Leu Pro Ser Pro
            225                 230                 235
 
ttg ttt act gat act tgg act gct gat ata cca gtt ggt act tta tgt   770
Leu Phe Thr Asp Thr Trp Thr Ala Asp Ile Pro Val Gly Thr Leu Cys
        240                 245                 250
 
cca gaa tgg gct caa aga ttg gga ttg cca gaa tct gtt gtt att tca   818
Pro Glu Trp Ala Gln Arg Leu Gly Leu Pro Glu Ser Val Val Ile Ser
    255                 260                 265
 
gga gga gct ttt gat tgt cac atg gga gct gtt ggt gct ggc gct caa   866
Gly Gly Ala Phe Asp Cys His Met Gly Ala Val Gly Ala Gly Ala Gln
270                 275                 280                 285
 
cct aat gca ttg gtt aaa gtt att gga aca tct act tgt gac att ttg   914
Pro Asn Ala Leu Val Lys Val Ile Gly Thr Ser Thr Cys Asp Ile Leu
                290                 295                 300
 
att gct gat aaa caa tct gtt gga gaa aga gct gtt aaa gga att tgt   962
Ile Ala Asp Lys Gln Ser Val Gly Glu Arg Ala Val Lys Gly Ile Cys
            305                 310                 315
 
gga caa gtt gat gga tct gtt gtt cca gga ttt att gga tta gaa gct   1010
Gly Gln Val Asp Gly Ser Val Val Pro Gly Phe Ile Gly Leu Glu Ala
        320                 325                 330
 
gga caa tct gct ttt ggt gac att tat gct tgg ttt ggt aga gtt ttg   1058
Gly Gln Ser Ala Phe Gly Asp Ile Tyr Ala Trp Phe Gly Arg Val Leu
    335                 340                 345
 
tct tgg cca tta gaa caa ctc gct gct caa cat cca gaa tta aaa gct   1106
Ser Trp Pro Leu Glu Gln Leu Ala Ala Gln His Pro Glu Leu Lys Ala
350                 355                 360                 365
 
caa att aac gct tct caa aaa caa ttg ttg cca gct ttg act gaa gca   1154
Gln Ile Asn Ala Ser Gln Lys Gln Leu Leu Pro Ala Leu Thr Glu Ala
                370                 375                 380
 
tgg gct aaa aat cca tct tta gat cat ttg cca gtt gtt ttg gat tgg   1202
Trp Ala Lys Asn Pro Ser Leu Asp His Leu Pro Val Val Leu Asp Trp
            385                 390                 395
 
ttt aat ggt aga aga tct cca aat gca aat caa aga tta aaa gga gtt   1250
Phe Asn Gly Arg Arg Ser Pro Asn Ala Asn Gln Arg Leu Lys Gly Val
        400                 405                 410
 
att act gat tta aat ttg gct act gat gct cca ttg ttg ttt ggt gga   1298
Ile Thr Asp Leu Asn Leu Ala Thr Asp Ala Pro Leu Leu Phe Gly Gly
    415                 420                 425
 
ttg att gct gct act gct ttt ggt gct aga gct att atg gaa tgt ttt   1346
Leu Ile Ala Ala Thr Ala Phe Gly Ala Arg Ala Ile Met Glu Cys Phe
430                 435                 440                 445
 
act gat cag gga att gct gtt aat aat gtt atg gct ttg gga gga att   1394
Thr Asp Gln Gly Ile Ala Val Asn Asn Val Met Ala Leu Gly Gly Ile
                450                 455                 460
 
gca agg aaa aat caa gtt att atg cag gct tgt tgt gac gtt tta aat   1442
Ala Arg Lys Asn Gln Val Ile Met Gln Ala Cys Cys Asp Val Leu Asn
            465                 470                 475
 
aga cca ttg caa att gta gct tct gat caa tgt tgt gct tta gga gct   1490
Arg Pro Leu Gln Ile Val Ala Ser Asp Gln Cys Cys Ala Leu Gly Ala
        480                 485                 490
 
gct att ttc gct gcc gta gct gca aaa gtt cat gcc gat ata cca tct   1538
Ala Ile Phe Ala Ala Val Ala Ala Lys Val His Ala Asp Ile Pro Ser
    495                 500                 505
 
gct caa cag aaa atg gct tcg gct gta gaa aag aca ttg caa cct aga   1586
Ala Gln Gln Lys Met Ala Ser Ala Val Glu Lys Thr Leu Gln Pro Arg
510                 515                 520                 525
 
tct gaa caa gca caa aga ttt gag caa ttg tat aga aga tat caa caa   1634
Ser Glu Gln Ala Gln Arg Phe Glu Gln Leu Tyr Arg Arg Tyr Gln Gln
                530                 535                 540
 
tgg gct atg agt gct gaa caa cat tat ttg cca act tct gca cct gct   1682
Trp Ala Met Ser Ala Glu Gln His Tyr Leu Pro Thr Ser Ala Pro Ala
            545                 550                 555
 
cag gct gca caa gct gta gct act tta gaattccgat g                  1720
Gln Ala Ala Gln Ala Val Ala Thr Leu
        560                 565
 

<210> 236
<211> 566
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in P. pastoris

<400> 236
Met Ala Ile Ala Ile Gly Leu Asp Phe Gly Ser Asp Ser Val Arg Ala
 1               5                  10                  15      
Leu Ala Val Asp Cys Ala Ser Gly Glu Glu Ile Ala Thr Ser Val Glu
            20                  25                  30          
Trp Tyr Pro Arg Trp Gln Lys Gly Gln Phe Cys Asp Ala Pro Asn Asn
        35                  40                  45              
Gln Phe Arg His His Pro Arg Asp Tyr Ile Glu Ser Met Glu Ala Ala
    50                  55                  60                  
Leu Lys Thr Val Leu Ala Glu Leu Ser Val Glu Gln Arg Ala Ala Val
65                  70                  75                  80  
Val Gly Ile Gly Val Asp Ser Thr Gly Ser Thr Pro Ala Pro Ile Asp
                85                  90                  95      
Ala Asp Gly Asn Val Leu Ala Leu Arg Pro Glu Phe Ala Glu Asn Pro
            100                 105                 110         
Asn Ala Met Phe Val Leu Trp Lys Asp His Thr Ala Val Glu Arg Ser
        115                 120                 125             
Glu Glu Ile Thr Arg Leu Cys His Ala Pro Gly Asn Val Asp Tyr Ser
    130                 135                 140                 
Arg Tyr Ile Gly Gly Ile Tyr Ser Ser Glu Trp Phe Trp Ala Lys Ile
145                 150                 155                 160 
Leu His Val Thr Arg Gln Asp Ser Ala Val Ala Gln Ser Ala Ala Ser
                165                 170                 175     
Trp Ile Glu Leu Cys Asp Trp Val Pro Ala Leu Leu Ser Gly Thr Thr
            180                 185                 190         
Arg Pro Gln Asp Ile Arg Arg Gly Arg Cys Ser Ala Gly His Lys Ser
        195                 200                 205             
Leu Trp His Glu Ser Trp Gly Gly Leu Pro Pro Ala Ser Phe Phe Asp
    210                 215                 220                 
Glu Leu Asp Pro Ile Leu Asn Arg His Leu Pro Ser Pro Leu Phe Thr
225                 230                 235                 240 
Asp Thr Trp Thr Ala Asp Ile Pro Val Gly Thr Leu Cys Pro Glu Trp
                245                 250                 255     
Ala Gln Arg Leu Gly Leu Pro Glu Ser Val Val Ile Ser Gly Gly Ala
            260                 265                 270         
Phe Asp Cys His Met Gly Ala Val Gly Ala Gly Ala Gln Pro Asn Ala
        275                 280                 285             
Leu Val Lys Val Ile Gly Thr Ser Thr Cys Asp Ile Leu Ile Ala Asp
    290                 295                 300                 
Lys Gln Ser Val Gly Glu Arg Ala Val Lys Gly Ile Cys Gly Gln Val
305                 310                 315                 320 
Asp Gly Ser Val Val Pro Gly Phe Ile Gly Leu Glu Ala Gly Gln Ser
                325                 330                 335     
Ala Phe Gly Asp Ile Tyr Ala Trp Phe Gly Arg Val Leu Ser Trp Pro
            340                 345                 350         
Leu Glu Gln Leu Ala Ala Gln His Pro Glu Leu Lys Ala Gln Ile Asn
        355                 360                 365             
Ala Ser Gln Lys Gln Leu Leu Pro Ala Leu Thr Glu Ala Trp Ala Lys
    370                 375                 380                 
Asn Pro Ser Leu Asp His Leu Pro Val Val Leu Asp Trp Phe Asn Gly
385                 390                 395                 400 
Arg Arg Ser Pro Asn Ala Asn Gln Arg Leu Lys Gly Val Ile Thr Asp
                405                 410                 415     
Leu Asn Leu Ala Thr Asp Ala Pro Leu Leu Phe Gly Gly Leu Ile Ala
            420                 425                 430         
Ala Thr Ala Phe Gly Ala Arg Ala Ile Met Glu Cys Phe Thr Asp Gln
        435                 440                 445             
Gly Ile Ala Val Asn Asn Val Met Ala Leu Gly Gly Ile Ala Arg Lys
    450                 455                 460                 
Asn Gln Val Ile Met Gln Ala Cys Cys Asp Val Leu Asn Arg Pro Leu
465                 470                 475                 480 
Gln Ile Val Ala Ser Asp Gln Cys Cys Ala Leu Gly Ala Ala Ile Phe
                485                 490                 495     
Ala Ala Val Ala Ala Lys Val His Ala Asp Ile Pro Ser Ala Gln Gln
            500                 505                 510         
Lys Met Ala Ser Ala Val Glu Lys Thr Leu Gln Pro Arg Ser Glu Gln
        515                 520                 525             
Ala Gln Arg Phe Glu Gln Leu Tyr Arg Arg Tyr Gln Gln Trp Ala Met
    530                 535                 540                 
Ser Ala Glu Gln His Tyr Leu Pro Thr Ser Ala Pro Ala Gln Ala Ala
545                 550                 555                 560 
Gln Ala Val Ala Thr Leu
                565     


<210> 237
<211> 1698
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in K. lactis

<220> 
<221> CDS            
<222> (1)...(1698)

<400> 237
atg gct att gct att ggt ttg gat ttc ggt tct gat tct gtt aga gct   48
Met Ala Ile Ala Ile Gly Leu Asp Phe Gly Ser Asp Ser Val Arg Ala
 1               5                   10                  15
 
ttg gct gtt gat tgt gct tct ggt gaa gaa att gct act tct gtt gaa   96
Leu Ala Val Asp Cys Ala Ser Gly Glu Glu Ile Ala Thr Ser Val Glu
             20                  25                  30
 
tgg tat cca agg tgg caa aaa ggt caa ttc tgt gat gct cca aat aat   144
Trp Tyr Pro Arg Trp Gln Lys Gly Gln Phe Cys Asp Ala Pro Asn Asn
         35                  40                  45
 
caa ttc aga cat cat cct aga gat tat att gaa tct atg gaa gct gct   192
Gln Phe Arg His His Pro Arg Asp Tyr Ile Glu Ser Met Glu Ala Ala
     50                  55                  60
 
tta aaa act gtt ttg gca gaa ttg tct gtt gaa caa aga gct gct gta   240
Leu Lys Thr Val Leu Ala Glu Leu Ser Val Glu Gln Arg Ala Ala Val
 65                  70                  75                  80
 
gtt ggt ata ggt gtt gat tct act ggt tct act cca gct cca att gat   288
Val Gly Ile Gly Val Asp Ser Thr Gly Ser Thr Pro Ala Pro Ile Asp
                 85                  90                  95
 
gct gat ggt aat gtt tta gcg ctt aga cca gag ttc gct gaa aat cca   336
Ala Asp Gly Asn Val Leu Ala Leu Arg Pro Glu Phe Ala Glu Asn Pro
            100                 105                 110
 
aat gct atg ttc gtt ttg tgg aaa gat cat act gct gtt gaa aga tct   384
Asn Ala Met Phe Val Leu Trp Lys Asp His Thr Ala Val Glu Arg Ser
        115                 120                 125
 
gaa gaa att act aga ttg tgt cat gct cca ggt aat gtt gat tat agc   432
Glu Glu Ile Thr Arg Leu Cys His Ala Pro Gly Asn Val Asp Tyr Ser
    130                 135                 140
 
aga tat att ggt ggt ata tat tct tct gaa tgg ttc tgg gct aaa att   480
Arg Tyr Ile Gly Gly Ile Tyr Ser Ser Glu Trp Phe Trp Ala Lys Ile
145                 150                 155                 160
 
ttg cat gtt act aga caa gat tct gca gtt gct caa tct gct gct tct   528
Leu His Val Thr Arg Gln Asp Ser Ala Val Ala Gln Ser Ala Ala Ser
                165                 170                 175
 
tgg att gaa ttg tgt gat tgg gtt cca gct ttg ttg tct gga act act   576
Trp Ile Glu Leu Cys Asp Trp Val Pro Ala Leu Leu Ser Gly Thr Thr
            180                 185                 190
 
aga cca caa gac att agg agg ggt aga tgt tct gct ggt cat aaa tct   624
Arg Pro Gln Asp Ile Arg Arg Gly Arg Cys Ser Ala Gly His Lys Ser
        195                 200                 205
 
tta tgg cat gaa tct tgg ggt ggt ttg cct cca gcg tct ttc ttc gat   672
Leu Trp His Glu Ser Trp Gly Gly Leu Pro Pro Ala Ser Phe Phe Asp
    210                 215                 220
 
gaa ttg gat cct ata tta aac aga cat ttg cca tct cct ttg ttc act   720
Glu Leu Asp Pro Ile Leu Asn Arg His Leu Pro Ser Pro Leu Phe Thr
225                 230                 235                 240
 
gat act tgg act gca gac atc cca gtt ggt aca tta tgt cca gaa tgg   768
Asp Thr Trp Thr Ala Asp Ile Pro Val Gly Thr Leu Cys Pro Glu Trp
                245                 250                 255
 
gct caa aga ttg ggt cta cca gaa tct gtt gtt att tct ggt ggt gct   816
Ala Gln Arg Leu Gly Leu Pro Glu Ser Val Val Ile Ser Gly Gly Ala
            260                 265                 270
 
ttc gat tgt cac atg ggt gct gta gga gca ggt gca cag cct aat gct   864
Phe Asp Cys His Met Gly Ala Val Gly Ala Gly Ala Gln Pro Asn Ala
        275                 280                 285
 
ttg gtt aaa gtt att gga act tct act tgt gac att ttg atc gct gat   912
Leu Val Lys Val Ile Gly Thr Ser Thr Cys Asp Ile Leu Ile Ala Asp
    290                 295                 300
 
aag caa tca gtt ggt gaa aga gcc gtt aaa gga att tgt ggt caa gtt   960
Lys Gln Ser Val Gly Glu Arg Ala Val Lys Gly Ile Cys Gly Gln Val
305                 310                 315                 320
 
gat ggt agt gtt gtt cca ggt ttc att ggt ctc gaa gct gga caa tct   1008
Asp Gly Ser Val Val Pro Gly Phe Ile Gly Leu Glu Ala Gly Gln Ser
                325                 330                 335
 
gcc ttc ggt gac att tat gct tgg ttc ggt aga gtt ttg tct tgg cca   1056
Ala Phe Gly Asp Ile Tyr Ala Trp Phe Gly Arg Val Leu Ser Trp Pro
            340                 345                 350
 
ttg gaa caa ttg gct gct caa cat cca gaa tta aag gct cag att aat   1104
Leu Glu Gln Leu Ala Ala Gln His Pro Glu Leu Lys Ala Gln Ile Asn
        355                 360                 365
 
gct tct caa aaa caa ttg ttg cca gcc ttg act gag gca tgg gct aag   1152
Ala Ser Gln Lys Gln Leu Leu Pro Ala Leu Thr Glu Ala Trp Ala Lys
    370                 375                 380
 
aat cca tct tta gat cat cta cct gtt gtt ttg gat tgg ttc aat ggt   1200
Asn Pro Ser Leu Asp His Leu Pro Val Val Leu Asp Trp Phe Asn Gly
385                 390                 395                 400
 
agg aga tca cca aat gca aat caa aga tta aag ggt gtt att act gat   1248
Arg Arg Ser Pro Asn Ala Asn Gln Arg Leu Lys Gly Val Ile Thr Asp
                405                 410                 415
 
tta aat ttg gct act gat gca cct ttg ttg ttc ggt ggt ctt att gct   1296
Leu Asn Leu Ala Thr Asp Ala Pro Leu Leu Phe Gly Gly Leu Ile Ala
            420                 425                 430
 
gct act gct ttt ggg gct cgt gct att atg gaa tgt ttc act gat caa   1344
Ala Thr Ala Phe Gly Ala Arg Ala Ile Met Glu Cys Phe Thr Asp Gln
        435                 440                 445
 
gga att gct gtt aat aat gtt atg gct ttg gga gga atc gct agg aag   1392
Gly Ile Ala Val Asn Asn Val Met Ala Leu Gly Gly Ile Ala Arg Lys
    450                 455                 460
 
aat caa gtt att atg cag gct tgt tgt gat gtt tta aat aga cca ttg   1440
Asn Gln Val Ile Met Gln Ala Cys Cys Asp Val Leu Asn Arg Pro Leu
465                 470                 475                 480
 
caa att gtt gct tct gat caa tgt tgt gct ctg gga gcg gct att ttc   1488
Gln Ile Val Ala Ser Asp Gln Cys Cys Ala Leu Gly Ala Ala Ile Phe
                485                 490                 495
 
gct gcg gta gct gcc aaa gtt cat gct gac att ccg tct gct cag caa   1536
Ala Ala Val Ala Ala Lys Val His Ala Asp Ile Pro Ser Ala Gln Gln
            500                 505                 510
 
aag atg gct tct gct gtc gag aag aca ttg caa cct aga tct gaa caa   1584
Lys Met Ala Ser Ala Val Glu Lys Thr Leu Gln Pro Arg Ser Glu Gln
        515                 520                 525
 
gct caa cgt ttc gaa caa ttg tat agg aga tat caa caa tgg gcc atg   1632
Ala Gln Arg Phe Glu Gln Leu Tyr Arg Arg Tyr Gln Gln Trp Ala Met
    530                 535                 540
 
tca gct gaa cag cat tac ttg cca act tct gct ccg gcc cag gcg gca   1680
Ser Ala Glu Gln His Tyr Leu Pro Thr Ser Ala Pro Ala Gln Ala Ala
545                 550                 555                 560
 
caa gct gtt gca act tta                                           1698
Gln Ala Val Ala Thr Leu
                565
 

<210> 238
<211> 566
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in K. lactis

<400> 238
Met Ala Ile Ala Ile Gly Leu Asp Phe Gly Ser Asp Ser Val Arg Ala
 1               5                  10                  15      
Leu Ala Val Asp Cys Ala Ser Gly Glu Glu Ile Ala Thr Ser Val Glu
            20                  25                  30          
Trp Tyr Pro Arg Trp Gln Lys Gly Gln Phe Cys Asp Ala Pro Asn Asn
        35                  40                  45              
Gln Phe Arg His His Pro Arg Asp Tyr Ile Glu Ser Met Glu Ala Ala
    50                  55                  60                  
Leu Lys Thr Val Leu Ala Glu Leu Ser Val Glu Gln Arg Ala Ala Val
65                  70                  75                  80  
Val Gly Ile Gly Val Asp Ser Thr Gly Ser Thr Pro Ala Pro Ile Asp
                85                  90                  95      
Ala Asp Gly Asn Val Leu Ala Leu Arg Pro Glu Phe Ala Glu Asn Pro
            100                 105                 110         
Asn Ala Met Phe Val Leu Trp Lys Asp His Thr Ala Val Glu Arg Ser
        115                 120                 125             
Glu Glu Ile Thr Arg Leu Cys His Ala Pro Gly Asn Val Asp Tyr Ser
    130                 135                 140                 
Arg Tyr Ile Gly Gly Ile Tyr Ser Ser Glu Trp Phe Trp Ala Lys Ile
145                 150                 155                 160 
Leu His Val Thr Arg Gln Asp Ser Ala Val Ala Gln Ser Ala Ala Ser
                165                 170                 175     
Trp Ile Glu Leu Cys Asp Trp Val Pro Ala Leu Leu Ser Gly Thr Thr
            180                 185                 190         
Arg Pro Gln Asp Ile Arg Arg Gly Arg Cys Ser Ala Gly His Lys Ser
        195                 200                 205             
Leu Trp His Glu Ser Trp Gly Gly Leu Pro Pro Ala Ser Phe Phe Asp
    210                 215                 220                 
Glu Leu Asp Pro Ile Leu Asn Arg His Leu Pro Ser Pro Leu Phe Thr
225                 230                 235                 240 
Asp Thr Trp Thr Ala Asp Ile Pro Val Gly Thr Leu Cys Pro Glu Trp
                245                 250                 255     
Ala Gln Arg Leu Gly Leu Pro Glu Ser Val Val Ile Ser Gly Gly Ala
            260                 265                 270         
Phe Asp Cys His Met Gly Ala Val Gly Ala Gly Ala Gln Pro Asn Ala
        275                 280                 285             
Leu Val Lys Val Ile Gly Thr Ser Thr Cys Asp Ile Leu Ile Ala Asp
    290                 295                 300                 
Lys Gln Ser Val Gly Glu Arg Ala Val Lys Gly Ile Cys Gly Gln Val
305                 310                 315                 320 
Asp Gly Ser Val Val Pro Gly Phe Ile Gly Leu Glu Ala Gly Gln Ser
                325                 330                 335     
Ala Phe Gly Asp Ile Tyr Ala Trp Phe Gly Arg Val Leu Ser Trp Pro
            340                 345                 350         
Leu Glu Gln Leu Ala Ala Gln His Pro Glu Leu Lys Ala Gln Ile Asn
        355                 360                 365             
Ala Ser Gln Lys Gln Leu Leu Pro Ala Leu Thr Glu Ala Trp Ala Lys
    370                 375                 380                 
Asn Pro Ser Leu Asp His Leu Pro Val Val Leu Asp Trp Phe Asn Gly
385                 390                 395                 400 
Arg Arg Ser Pro Asn Ala Asn Gln Arg Leu Lys Gly Val Ile Thr Asp
                405                 410                 415     
Leu Asn Leu Ala Thr Asp Ala Pro Leu Leu Phe Gly Gly Leu Ile Ala
            420                 425                 430         
Ala Thr Ala Phe Gly Ala Arg Ala Ile Met Glu Cys Phe Thr Asp Gln
        435                 440                 445             
Gly Ile Ala Val Asn Asn Val Met Ala Leu Gly Gly Ile Ala Arg Lys
    450                 455                 460                 
Asn Gln Val Ile Met Gln Ala Cys Cys Asp Val Leu Asn Arg Pro Leu
465                 470                 475                 480 
Gln Ile Val Ala Ser Asp Gln Cys Cys Ala Leu Gly Ala Ala Ile Phe
                485                 490                 495     
Ala Ala Val Ala Ala Lys Val His Ala Asp Ile Pro Ser Ala Gln Gln
            500                 505                 510         
Lys Met Ala Ser Ala Val Glu Lys Thr Leu Gln Pro Arg Ser Glu Gln
        515                 520                 525             
Ala Gln Arg Phe Glu Gln Leu Tyr Arg Arg Tyr Gln Gln Trp Ala Met
    530                 535                 540                 
Ser Ala Glu Gln His Tyr Leu Pro Thr Ser Ala Pro Ala Gln Ala Ala
545                 550                 555                 560 
Gln Ala Val Ala Thr Leu
                565     


<210> 239
<211> 1698
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in Z. mobilis

<220> 
<221> CDS            
<222> (1)...(1698)

<400> 239
atg gcc att gca att ggt ttg gat ttt ggt tct gat tct gtt cgt gcc   48
Met Ala Ile Ala Ile Gly Leu Asp Phe Gly Ser Asp Ser Val Arg Ala
 1               5                   10                  15
 
ctt gcc gtt gat tgt gcc tct ggt gaa gaa att gcc acc tct gtt gaa   96
Leu Ala Val Asp Cys Ala Ser Gly Glu Glu Ile Ala Thr Ser Val Glu
             20                  25                  30
 
tgg tat ccg cgt tgg cag aaa ggt cag ttt tgt gat gct ccg aat aat   144
Trp Tyr Pro Arg Trp Gln Lys Gly Gln Phe Cys Asp Ala Pro Asn Asn
         35                  40                  45
 
cag ttt cgt cat cat ccg aga gat tat att gaa tct atg gaa gct gcc   192
Gln Phe Arg His His Pro Arg Asp Tyr Ile Glu Ser Met Glu Ala Ala
     50                  55                  60
 
ctt aaa acc gtt ttg gcc gaa ttg tct gtt gaa cag cgt gct gcg gta   240
Leu Lys Thr Val Leu Ala Glu Leu Ser Val Glu Gln Arg Ala Ala Val
 65                  70                  75                  80
 
gtt ggt ata ggt gtt gat tct acc ggt tct acc ccg gcc ccg att gac   288
Val Gly Ile Gly Val Asp Ser Thr Gly Ser Thr Pro Ala Pro Ile Asp
                 85                  90                  95
 
gcc gat ggt aat gtt ttg gcc ctt cgt ccg gaa ttt gcc gaa aat ccg   336
Ala Asp Gly Asn Val Leu Ala Leu Arg Pro Glu Phe Ala Glu Asn Pro
            100                 105                 110
 
aat gcc atg ttt gtt ttg tgg aaa gat cat acc gcc gtt gaa cgt tct   384
Asn Ala Met Phe Val Leu Trp Lys Asp His Thr Ala Val Glu Arg Ser
        115                 120                 125
 
gaa gaa att acc cgc ttg tgt cat gcc ccg ggt aat gtt gat tat tct   432
Glu Glu Ile Thr Arg Leu Cys His Ala Pro Gly Asn Val Asp Tyr Ser
    130                 135                 140
 
cgt tat att ggt ggc atc tat tct tct gaa tgg ttt tgg gct aag att   480
Arg Tyr Ile Gly Gly Ile Tyr Ser Ser Glu Trp Phe Trp Ala Lys Ile
145                 150                 155                 160
 
ttg cat gtt acc cgc cag gat tct gcc gtt gcc cag tct gcc gcc tca   528
Leu His Val Thr Arg Gln Asp Ser Ala Val Ala Gln Ser Ala Ala Ser
                165                 170                 175
 
tgg att gaa ttg tgt gat tgg gtt ccg gct ctt ttg tct ggc acc acc   576
Trp Ile Glu Leu Cys Asp Trp Val Pro Ala Leu Leu Ser Gly Thr Thr
            180                 185                 190
 
cga ccg cag gat atc cgt cgt ggt cgt tgt tct gct ggt cat aaa tct   624
Arg Pro Gln Asp Ile Arg Arg Gly Arg Cys Ser Ala Gly His Lys Ser
        195                 200                 205
 
ttg tgg cat gaa tct tgg ggt ggt ttg cca cca gcc agc ttt ttc gat   672
Leu Trp His Glu Ser Trp Gly Gly Leu Pro Pro Ala Ser Phe Phe Asp
    210                 215                 220
 
gaa ttg gat ccg att ttg aat cgt cat ttg ccg tct ccg ttg ttt acc   720
Glu Leu Asp Pro Ile Leu Asn Arg His Leu Pro Ser Pro Leu Phe Thr
225                 230                 235                 240
 
gat acc tgg acc gct gac att ccg gtt ggc acc ttg tgt ccg gag tgg   768
Asp Thr Trp Thr Ala Asp Ile Pro Val Gly Thr Leu Cys Pro Glu Trp
                245                 250                 255
 
gca cag cgt ttg ggt ttg ccg gaa tct gtt gtc att tct gga ggc gct   816
Ala Gln Arg Leu Gly Leu Pro Glu Ser Val Val Ile Ser Gly Gly Ala
            260                 265                 270
 
ttc gat tgt cac atg ggt gcc gtt ggt gct ggt gca cag cca aat gcc   864
Phe Asp Cys His Met Gly Ala Val Gly Ala Gly Ala Gln Pro Asn Ala
        275                 280                 285
 
ctt gtt aaa gtc att gga acc tct acc tgt gac att ttg att gcc gat   912
Leu Val Lys Val Ile Gly Thr Ser Thr Cys Asp Ile Leu Ile Ala Asp
    290                 295                 300
 
aaa cag tct gtt ggt gaa cgt gcc gtg aaa ggt ata tgt ggt cag gtt   960
Lys Gln Ser Val Gly Glu Arg Ala Val Lys Gly Ile Cys Gly Gln Val
305                 310                 315                 320
 
gat ggt tct gtt gtt ccg ggt ttt att ggt ttg gaa gct gga caa tct   1008
Asp Gly Ser Val Val Pro Gly Phe Ile Gly Leu Glu Ala Gly Gln Ser
                325                 330                 335
 
gct ttc ggt gac att tat gcc tgg ttt ggt cgt gtt ttg tct tgg ccg   1056
Ala Phe Gly Asp Ile Tyr Ala Trp Phe Gly Arg Val Leu Ser Trp Pro
            340                 345                 350
 
tta gaa cag ttg gcc gct cag cat ccg gaa ttg aaa gcc cag att aat   1104
Leu Glu Gln Leu Ala Ala Gln His Pro Glu Leu Lys Ala Gln Ile Asn
        355                 360                 365
 
gcc tct cag aaa cag ttg ttg cct gct ctt acc gag gcc tgg gct aaa   1152
Ala Ser Gln Lys Gln Leu Leu Pro Ala Leu Thr Glu Ala Trp Ala Lys
    370                 375                 380
 
aat ccg tct ttg gat cat ttg cct gtt gtt ttg gat tgg ttt aat ggt   1200
Asn Pro Ser Leu Asp His Leu Pro Val Val Leu Asp Trp Phe Asn Gly
385                 390                 395                 400
 
cgt cgt tct ccg aat gca aac cag cgt ctt aaa ggt gtt atc acc gat   1248
Arg Arg Ser Pro Asn Ala Asn Gln Arg Leu Lys Gly Val Ile Thr Asp
                405                 410                 415
 
ttg aat ttg gcc acc gac gcc ccg ttg ttg ttt ggt ggt ttg att gca   1296
Leu Asn Leu Ala Thr Asp Ala Pro Leu Leu Phe Gly Gly Leu Ile Ala
            420                 425                 430
 
gct acc gcc ttc ggt gct cgg gcg atc atg gaa tgt ttt acc gat cag   1344
Ala Thr Ala Phe Gly Ala Arg Ala Ile Met Glu Cys Phe Thr Asp Gln
        435                 440                 445
 
ggc att gcc gtt aat aat gtt atg gcg ttg ggt ggt ata gca cgt aaa   1392
Gly Ile Ala Val Asn Asn Val Met Ala Leu Gly Gly Ile Ala Arg Lys
    450                 455                 460
 
aat cag gtc att atg cag gct tgt tgt gat gtt ttg aat cgt ccg ttg   1440
Asn Gln Val Ile Met Gln Ala Cys Cys Asp Val Leu Asn Arg Pro Leu
465                 470                 475                 480
 
cag att gtt gcc tct gat cag tgt tgt gcg ctt gga gct gct atc ttt   1488
Gln Ile Val Ala Ser Asp Gln Cys Cys Ala Leu Gly Ala Ala Ile Phe
                485                 490                 495
 
gcc gca gtt gcc gca aaa gtt cat gct gat atc ccg tct gcc caa cag   1536
Ala Ala Val Ala Ala Lys Val His Ala Asp Ile Pro Ser Ala Gln Gln
            500                 505                 510
 
aaa atg gcc tct gct gtc gag aaa acc ttg cag ccg cgc tct gaa cag   1584
Lys Met Ala Ser Ala Val Glu Lys Thr Leu Gln Pro Arg Ser Glu Gln
        515                 520                 525
 
gcc cag aga ttt gaa cag ttg tat cgt cgt tat cag caa tgg gct atg   1632
Ala Gln Arg Phe Glu Gln Leu Tyr Arg Arg Tyr Gln Gln Trp Ala Met
    530                 535                 540
 
tct gcg gaa cag cat tat ttg ccg acc tct gct ccc gct cag gca gcg   1680
Ser Ala Glu Gln His Tyr Leu Pro Thr Ser Ala Pro Ala Gln Ala Ala
545                 550                 555                 560
 
cag gca gtt gcg acc ttg                                           1698
Gln Ala Val Ala Thr Leu
                565
 

<210> 240
<211> 566
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in Z. mobilis

<400> 240
Met Ala Ile Ala Ile Gly Leu Asp Phe Gly Ser Asp Ser Val Arg Ala
 1               5                  10                  15      
Leu Ala Val Asp Cys Ala Ser Gly Glu Glu Ile Ala Thr Ser Val Glu
            20                  25                  30          
Trp Tyr Pro Arg Trp Gln Lys Gly Gln Phe Cys Asp Ala Pro Asn Asn
        35                  40                  45              
Gln Phe Arg His His Pro Arg Asp Tyr Ile Glu Ser Met Glu Ala Ala
    50                  55                  60                  
Leu Lys Thr Val Leu Ala Glu Leu Ser Val Glu Gln Arg Ala Ala Val
65                  70                  75                  80  
Val Gly Ile Gly Val Asp Ser Thr Gly Ser Thr Pro Ala Pro Ile Asp
                85                  90                  95      
Ala Asp Gly Asn Val Leu Ala Leu Arg Pro Glu Phe Ala Glu Asn Pro
            100                 105                 110         
Asn Ala Met Phe Val Leu Trp Lys Asp His Thr Ala Val Glu Arg Ser
        115                 120                 125             
Glu Glu Ile Thr Arg Leu Cys His Ala Pro Gly Asn Val Asp Tyr Ser
    130                 135                 140                 
Arg Tyr Ile Gly Gly Ile Tyr Ser Ser Glu Trp Phe Trp Ala Lys Ile
145                 150                 155                 160 
Leu His Val Thr Arg Gln Asp Ser Ala Val Ala Gln Ser Ala Ala Ser
                165                 170                 175     
Trp Ile Glu Leu Cys Asp Trp Val Pro Ala Leu Leu Ser Gly Thr Thr
            180                 185                 190         
Arg Pro Gln Asp Ile Arg Arg Gly Arg Cys Ser Ala Gly His Lys Ser
        195                 200                 205             
Leu Trp His Glu Ser Trp Gly Gly Leu Pro Pro Ala Ser Phe Phe Asp
    210                 215                 220                 
Glu Leu Asp Pro Ile Leu Asn Arg His Leu Pro Ser Pro Leu Phe Thr
225                 230                 235                 240 
Asp Thr Trp Thr Ala Asp Ile Pro Val Gly Thr Leu Cys Pro Glu Trp
                245                 250                 255     
Ala Gln Arg Leu Gly Leu Pro Glu Ser Val Val Ile Ser Gly Gly Ala
            260                 265                 270         
Phe Asp Cys His Met Gly Ala Val Gly Ala Gly Ala Gln Pro Asn Ala
        275                 280                 285             
Leu Val Lys Val Ile Gly Thr Ser Thr Cys Asp Ile Leu Ile Ala Asp
    290                 295                 300                 
Lys Gln Ser Val Gly Glu Arg Ala Val Lys Gly Ile Cys Gly Gln Val
305                 310                 315                 320 
Asp Gly Ser Val Val Pro Gly Phe Ile Gly Leu Glu Ala Gly Gln Ser
                325                 330                 335     
Ala Phe Gly Asp Ile Tyr Ala Trp Phe Gly Arg Val Leu Ser Trp Pro
            340                 345                 350         
Leu Glu Gln Leu Ala Ala Gln His Pro Glu Leu Lys Ala Gln Ile Asn
        355                 360                 365             
Ala Ser Gln Lys Gln Leu Leu Pro Ala Leu Thr Glu Ala Trp Ala Lys
    370                 375                 380                 
Asn Pro Ser Leu Asp His Leu Pro Val Val Leu Asp Trp Phe Asn Gly
385                 390                 395                 400 
Arg Arg Ser Pro Asn Ala Asn Gln Arg Leu Lys Gly Val Ile Thr Asp
                405                 410                 415     
Leu Asn Leu Ala Thr Asp Ala Pro Leu Leu Phe Gly Gly Leu Ile Ala
            420                 425                 430         
Ala Thr Ala Phe Gly Ala Arg Ala Ile Met Glu Cys Phe Thr Asp Gln
        435                 440                 445             
Gly Ile Ala Val Asn Asn Val Met Ala Leu Gly Gly Ile Ala Arg Lys
    450                 455                 460                 
Asn Gln Val Ile Met Gln Ala Cys Cys Asp Val Leu Asn Arg Pro Leu
465                 470                 475                 480 
Gln Ile Val Ala Ser Asp Gln Cys Cys Ala Leu Gly Ala Ala Ile Phe
                485                 490                 495     
Ala Ala Val Ala Ala Lys Val His Ala Asp Ile Pro Ser Ala Gln Gln
            500                 505                 510         
Lys Met Ala Ser Ala Val Glu Lys Thr Leu Gln Pro Arg Ser Glu Gln
        515                 520                 525             
Ala Gln Arg Phe Glu Gln Leu Tyr Arg Arg Tyr Gln Gln Trp Ala Met
    530                 535                 540                 
Ser Ala Glu Gln His Tyr Leu Pro Thr Ser Ala Pro Ala Gln Ala Ala
545                 550                 555                 560 
Gln Ala Val Ala Thr Leu
                565     


<210> 241
<211> 696
<212> DNA
<213> E. coli

<220> 
<221> CDS            
<222> (1)...(696)

<400> 241
atg tta gaa gat ctc aaa cgc cag gta tta gag gcc aac ctg gcg ctg   48
Met Leu Glu Asp Leu Lys Arg Gln Val Leu Glu Ala Asn Leu Ala Leu
 1               5                   10                  15
 
cca aaa cat aac ctg gtc acg ctc aca tgg ggc aac gtc agc gcc gtt   96
Pro Lys His Asn Leu Val Thr Leu Thr Trp Gly Asn Val Ser Ala Val
             20                  25                  30
 
gat cgc gag cgc ggc gtc ttt gtg atc aaa cct tcc ggc gtc gat tac   144
Asp Arg Glu Arg Gly Val Phe Val Ile Lys Pro Ser Gly Val Asp Tyr
         35                  40                  45
 
agc atc atg acc gct gac gat atg gtc gtg gtt agc atc gaa acc ggt   192
Ser Ile Met Thr Ala Asp Asp Met Val Val Val Ser Ile Glu Thr Gly
     50                  55                  60
 
gaa gtg gtt gaa ggt gcg aaa aag ccc tcc tcc gat acg cca act cac   240
Glu Val Val Glu Gly Ala Lys Lys Pro Ser Ser Asp Thr Pro Thr His
 65                  70                  75                  80
 
cga ctg ctc tat cag gca ttc ccg tcc att ggc ggc att gtg cac aca   288
Arg Leu Leu Tyr Gln Ala Phe Pro Ser Ile Gly Gly Ile Val His Thr
                 85                  90                  95
 
cac tcg cgc cac gcc act atc tgg gcg cag gcg ggc cag tcg att cca   336
His Ser Arg His Ala Thr Ile Trp Ala Gln Ala Gly Gln Ser Ile Pro
            100                 105                 110
 
gca acc ggc acc acc cac gcc gac tat ttc tac ggc acc att ccc tgc   384
Ala Thr Gly Thr Thr His Ala Asp Tyr Phe Tyr Gly Thr Ile Pro Cys
        115                 120                 125
 
acc cgc aaa atg acc gac gca gaa atc aac ggt gaa tat gag tgg gaa   432
Thr Arg Lys Met Thr Asp Ala Glu Ile Asn Gly Glu Tyr Glu Trp Glu
    130                 135                 140
 
acc ggt aac gtc atc gta gaa acc ttc gaa aaa cag ggt atc gat gca   480
Thr Gly Asn Val Ile Val Glu Thr Phe Glu Lys Gln Gly Ile Asp Ala
145                 150                 155                 160
 
gcg caa atg ccc ggc gtc ctg gtc cat tct cac ggc cca ttt gca tgg   528
Ala Gln Met Pro Gly Val Leu Val His Ser His Gly Pro Phe Ala Trp
                165                 170                 175
 
ggc aaa aat gcc gaa gat gcg gtg cat aac gcc atc gtg ctg gaa gag   576
Gly Lys Asn Ala Glu Asp Ala Val His Asn Ala Ile Val Leu Glu Glu
            180                 185                 190
 
gtc gct tat atg ggg ata ttc tgc cgt cag tta gcg ccg cag tta ccg   624
Val Ala Tyr Met Gly Ile Phe Cys Arg Gln Leu Ala Pro Gln Leu Pro
        195                 200                 205
 
gat atg cag caa acg ctg ctg aat aaa cac tat ctg cgt aag cat ggc   672
Asp Met Gln Gln Thr Leu Leu Asn Lys His Tyr Leu Arg Lys His Gly
    210                 215                 220
 
gcg aag gca tat tac ggg cag taa                                   696
Ala Lys Ala Tyr Tyr Gly Gln  *
225                 230
 

<210> 242
<211> 231
<212> PRT
<213> E. coli

<400> 242
Met Leu Glu Asp Leu Lys Arg Gln Val Leu Glu Ala Asn Leu Ala Leu
 1               5                  10                  15      
Pro Lys His Asn Leu Val Thr Leu Thr Trp Gly Asn Val Ser Ala Val
            20                  25                  30          
Asp Arg Glu Arg Gly Val Phe Val Ile Lys Pro Ser Gly Val Asp Tyr
        35                  40                  45              
Ser Ile Met Thr Ala Asp Asp Met Val Val Val Ser Ile Glu Thr Gly
    50                  55                  60                  
Glu Val Val Glu Gly Ala Lys Lys Pro Ser Ser Asp Thr Pro Thr His
65                  70                  75                  80  
Arg Leu Leu Tyr Gln Ala Phe Pro Ser Ile Gly Gly Ile Val His Thr
                85                  90                  95      
His Ser Arg His Ala Thr Ile Trp Ala Gln Ala Gly Gln Ser Ile Pro
            100                 105                 110         
Ala Thr Gly Thr Thr His Ala Asp Tyr Phe Tyr Gly Thr Ile Pro Cys
        115                 120                 125             
Thr Arg Lys Met Thr Asp Ala Glu Ile Asn Gly Glu Tyr Glu Trp Glu
    130                 135                 140                 
Thr Gly Asn Val Ile Val Glu Thr Phe Glu Lys Gln Gly Ile Asp Ala
145                 150                 155                 160 
Ala Gln Met Pro Gly Val Leu Val His Ser His Gly Pro Phe Ala Trp
                165                 170                 175     
Gly Lys Asn Ala Glu Asp Ala Val His Asn Ala Ile Val Leu Glu Glu
            180                 185                 190         
Val Ala Tyr Met Gly Ile Phe Cys Arg Gln Leu Ala Pro Gln Leu Pro
        195                 200                 205             
Asp Met Gln Gln Thr Leu Leu Asn Lys His Tyr Leu Arg Lys His Gly
    210                 215                 220                 
Ala Lys Ala Tyr Tyr Gly Gln
225                 230     


<210> 243
<211> 693
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in S. cerevisiae

<220> 
<221> CDS            
<222> (1)...(693)

<400> 243
atg ttg gaa gat tta aaa aga caa gtt ttg gaa gca aat ttg gcg ttg   48
Met Leu Glu Asp Leu Lys Arg Gln Val Leu Glu Ala Asn Leu Ala Leu
 1               5                   10                  15
 
cct aaa cat aat ttg gtt aca ttg act tgg ggt aat gtt tca gct gtt   96
Pro Lys His Asn Leu Val Thr Leu Thr Trp Gly Asn Val Ser Ala Val
             20                  25                  30
 
gat aga gaa aga ggt gtt ttt gta att aaa cca tct ggt gtt gat tat   144
Asp Arg Glu Arg Gly Val Phe Val Ile Lys Pro Ser Gly Val Asp Tyr
         35                  40                  45
 
agt att atg act gct gat gat atg gtt gtt gtt tcc att gaa act gga   192
Ser Ile Met Thr Ala Asp Asp Met Val Val Val Ser Ile Glu Thr Gly
     50                  55                  60
 
gaa gtt gtt gaa ggt gct aaa aag cca tct tct gat act cca act cat   240
Glu Val Val Glu Gly Ala Lys Lys Pro Ser Ser Asp Thr Pro Thr His
 65                  70                  75                  80
 
aga ttg ttg tat caa gca ttt cca tct att ggt gga att gtt cat act   288
Arg Leu Leu Tyr Gln Ala Phe Pro Ser Ile Gly Gly Ile Val His Thr
                 85                  90                  95
 
cat tct aga cat gct aca att tgg gct caa gct ggt caa tct att cct   336
His Ser Arg His Ala Thr Ile Trp Ala Gln Ala Gly Gln Ser Ile Pro
            100                 105                 110
 
gca act ggt act act cat gct gat tat ttt tat ggt act att cca tgt   384
Ala Thr Gly Thr Thr His Ala Asp Tyr Phe Tyr Gly Thr Ile Pro Cys
        115                 120                 125
 
act aga aaa atg act gat gct gaa att aat ggt gaa tat gaa tgg gaa   432
Thr Arg Lys Met Thr Asp Ala Glu Ile Asn Gly Glu Tyr Glu Trp Glu
    130                 135                 140
 
act ggt aat gta att gtt gaa act ttt gaa aaa caa gga att gat gct   480
Thr Gly Asn Val Ile Val Glu Thr Phe Glu Lys Gln Gly Ile Asp Ala
145                 150                 155                 160
 
gct caa atg cca ggt gtt ttg gtt cat tct cat ggt cct ttt gct tgg   528
Ala Gln Met Pro Gly Val Leu Val His Ser His Gly Pro Phe Ala Trp
                165                 170                 175
 
ggt aaa aat gct gaa gat gct gtt cat aat gct att gtt ttg gaa gaa   576
Gly Lys Asn Ala Glu Asp Ala Val His Asn Ala Ile Val Leu Glu Glu
            180                 185                 190
 
gtt gct tat atg gga att ttc tgt aga caa ttg gct cca caa ttg cca   624
Val Ala Tyr Met Gly Ile Phe Cys Arg Gln Leu Ala Pro Gln Leu Pro
        195                 200                 205
 
gat atg caa caa aca ttg tta aat aaa cat tat ttg aga aaa cat ggt   672
Asp Met Gln Gln Thr Leu Leu Asn Lys His Tyr Leu Arg Lys His Gly
    210                 215                 220
 
gct aaa gca tat tat ggt caa                                       693
Ala Lys Ala Tyr Tyr Gly Gln
225                 230
 

<210> 244
<211> 231
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in S. cerevisiae

<400> 244
Met Leu Glu Asp Leu Lys Arg Gln Val Leu Glu Ala Asn Leu Ala Leu
 1               5                  10                  15      
Pro Lys His Asn Leu Val Thr Leu Thr Trp Gly Asn Val Ser Ala Val
            20                  25                  30          
Asp Arg Glu Arg Gly Val Phe Val Ile Lys Pro Ser Gly Val Asp Tyr
        35                  40                  45              
Ser Ile Met Thr Ala Asp Asp Met Val Val Val Ser Ile Glu Thr Gly
    50                  55                  60                  
Glu Val Val Glu Gly Ala Lys Lys Pro Ser Ser Asp Thr Pro Thr His
65                  70                  75                  80  
Arg Leu Leu Tyr Gln Ala Phe Pro Ser Ile Gly Gly Ile Val His Thr
                85                  90                  95      
His Ser Arg His Ala Thr Ile Trp Ala Gln Ala Gly Gln Ser Ile Pro
            100                 105                 110         
Ala Thr Gly Thr Thr His Ala Asp Tyr Phe Tyr Gly Thr Ile Pro Cys
        115                 120                 125             
Thr Arg Lys Met Thr Asp Ala Glu Ile Asn Gly Glu Tyr Glu Trp Glu
    130                 135                 140                 
Thr Gly Asn Val Ile Val Glu Thr Phe Glu Lys Gln Gly Ile Asp Ala
145                 150                 155                 160 
Ala Gln Met Pro Gly Val Leu Val His Ser His Gly Pro Phe Ala Trp
                165                 170                 175     
Gly Lys Asn Ala Glu Asp Ala Val His Asn Ala Ile Val Leu Glu Glu
            180                 185                 190         
Val Ala Tyr Met Gly Ile Phe Cys Arg Gln Leu Ala Pro Gln Leu Pro
        195                 200                 205             
Asp Met Gln Gln Thr Leu Leu Asn Lys His Tyr Leu Arg Lys His Gly
    210                 215                 220                 
Ala Lys Ala Tyr Tyr Gly Gln
225                 230     


<210> 245
<211> 715
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in S. cerevisiae

<220> 
<221> CDS            
<222> (12)...(704)

<400> 245
tactcaagct t atg ttg gaa gat tta aaa aga caa gtt ttg gaa gca aat  50
             Met Leu Glu Asp Leu Lys Arg Gln Val Leu Glu Ala Asn
              1               5                   10
 
ttg gcg ttg cct aaa cat aat ttg gtt aca ttg act tgg ggt aat gtt   98
Leu Ala Leu Pro Lys His Asn Leu Val Thr Leu Thr Trp Gly Asn Val
     15                  20                  25
 
tca gct gtt gat aga gaa aga ggt gtt ttt gta att aaa cca tct ggt   146
Ser Ala Val Asp Arg Glu Arg Gly Val Phe Val Ile Lys Pro Ser Gly
 30                  35                  40                  45
 
gtt gat tat agt att atg act gct gat gat atg gtt gtt gtt tcc att   194
Val Asp Tyr Ser Ile Met Thr Ala Asp Asp Met Val Val Val Ser Ile
                 50                  55                  60
 
gaa act gga gaa gtt gtt gaa ggt gct aaa aag cca tct tct gat act   242
Glu Thr Gly Glu Val Val Glu Gly Ala Lys Lys Pro Ser Ser Asp Thr
             65                  70                  75
 
cca act cat aga ttg ttg tat caa gca ttt cca tct att ggt gga att   290
Pro Thr His Arg Leu Leu Tyr Gln Ala Phe Pro Ser Ile Gly Gly Ile
         80                  85                  90
 
gtt cat act cat tct aga cat gct aca att tgg gct caa gct ggt caa   338
Val His Thr His Ser Arg His Ala Thr Ile Trp Ala Gln Ala Gly Gln
     95                 100                 105
 
tct att cct gca act ggt act act cat gct gat tat ttt tat ggt act   386
Ser Ile Pro Ala Thr Gly Thr Thr His Ala Asp Tyr Phe Tyr Gly Thr
110                 115                 120                 125
 
att cca tgt act aga aaa atg act gat gct gaa att aat ggt gaa tat   434
Ile Pro Cys Thr Arg Lys Met Thr Asp Ala Glu Ile Asn Gly Glu Tyr
                130                 135                 140
 
gaa tgg gaa act ggt aat gta att gtt gaa act ttt gaa aaa caa gga   482
Glu Trp Glu Thr Gly Asn Val Ile Val Glu Thr Phe Glu Lys Gln Gly
            145                 150                 155
 
att gat gct gct caa atg cca ggt gtt ttg gtt cat tct cat ggt cct   530
Ile Asp Ala Ala Gln Met Pro Gly Val Leu Val His Ser His Gly Pro
        160                 165                 170
 
ttt gct tgg ggt aaa aat gct gaa gat gct gtt cat aat gct att gtt   578
Phe Ala Trp Gly Lys Asn Ala Glu Asp Ala Val His Asn Ala Ile Val
    175                 180                 185
 
ttg gaa gaa gtt gct tat atg gga att ttc tgt aga caa ttg gct cca   626
Leu Glu Glu Val Ala Tyr Met Gly Ile Phe Cys Arg Gln Leu Ala Pro
190                 195                 200                 205
 
caa ttg cca gat atg caa caa aca ttg tta aat aaa cat tat ttg aga   674
Gln Leu Pro Asp Met Gln Gln Thr Leu Leu Asn Lys His Tyr Leu Arg
                210                 215                 220
 
aaa cat ggt gct aaa gca tat tat ggt caa gaattccgat g              715
Lys His Gly Ala Lys Ala Tyr Tyr Gly Gln
            225                 230
 

<210> 246
<211> 231
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in S. cerevisiae

<400> 246
Met Leu Glu Asp Leu Lys Arg Gln Val Leu Glu Ala Asn Leu Ala Leu
 1               5                  10                  15      
Pro Lys His Asn Leu Val Thr Leu Thr Trp Gly Asn Val Ser Ala Val
            20                  25                  30          
Asp Arg Glu Arg Gly Val Phe Val Ile Lys Pro Ser Gly Val Asp Tyr
        35                  40                  45              
Ser Ile Met Thr Ala Asp Asp Met Val Val Val Ser Ile Glu Thr Gly
    50                  55                  60                  
Glu Val Val Glu Gly Ala Lys Lys Pro Ser Ser Asp Thr Pro Thr His
65                  70                  75                  80  
Arg Leu Leu Tyr Gln Ala Phe Pro Ser Ile Gly Gly Ile Val His Thr
                85                  90                  95      
His Ser Arg His Ala Thr Ile Trp Ala Gln Ala Gly Gln Ser Ile Pro
            100                 105                 110         
Ala Thr Gly Thr Thr His Ala Asp Tyr Phe Tyr Gly Thr Ile Pro Cys
        115                 120                 125             
Thr Arg Lys Met Thr Asp Ala Glu Ile Asn Gly Glu Tyr Glu Trp Glu
    130                 135                 140                 
Thr Gly Asn Val Ile Val Glu Thr Phe Glu Lys Gln Gly Ile Asp Ala
145                 150                 155                 160 
Ala Gln Met Pro Gly Val Leu Val His Ser His Gly Pro Phe Ala Trp
                165                 170                 175     
Gly Lys Asn Ala Glu Asp Ala Val His Asn Ala Ile Val Leu Glu Glu
            180                 185                 190         
Val Ala Tyr Met Gly Ile Phe Cys Arg Gln Leu Ala Pro Gln Leu Pro
        195                 200                 205             
Asp Met Gln Gln Thr Leu Leu Asn Lys His Tyr Leu Arg Lys His Gly
    210                 215                 220                 
Ala Lys Ala Tyr Tyr Gly Gln
225                 230     


<210> 247
<211> 721
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in S. cerevisiae

<220> 
<221> CDS            
<222> (15)...(707)

<400> 247
gaatactcca tatg atg ttg gaa gat tta aaa aga caa gtt ttg gaa gca   50
                Met Leu Glu Asp Leu Lys Arg Gln Val Leu Glu Ala
                 1               5                   10
 
aat ttg gcg ttg cct aaa cat aat ttg gtt aca ttg act tgg ggt aat   98
Asn Leu Ala Leu Pro Lys His Asn Leu Val Thr Leu Thr Trp Gly Asn
         15                  20                  25
 
gtt tca gct gtt gat aga gaa aga ggt gtt ttt gta att aaa cca tct   146
Val Ser Ala Val Asp Arg Glu Arg Gly Val Phe Val Ile Lys Pro Ser
     30                  35                  40
 
ggt gtt gat tat agt att atg act gct gat gat atg gtt gtt gtt tcc   194
Gly Val Asp Tyr Ser Ile Met Thr Ala Asp Asp Met Val Val Val Ser
 45                  50                  55                  60
 
att gaa act gga gaa gtt gtt gaa ggt gct aaa aag cca tct tct gat   242
Ile Glu Thr Gly Glu Val Val Glu Gly Ala Lys Lys Pro Ser Ser Asp
                 65                  70                  75
 
act cca act cat aga ttg ttg tat caa gca ttt cca tct att ggt gga   290
Thr Pro Thr His Arg Leu Leu Tyr Gln Ala Phe Pro Ser Ile Gly Gly
             80                  85                  90
 
att gtt cat act cat tct aga cat gct aca att tgg gct caa gct ggt   338
Ile Val His Thr His Ser Arg His Ala Thr Ile Trp Ala Gln Ala Gly
         95                 100                 105
 
caa tct att cct gca act ggt act act cat gct gat tat ttt tat ggt   386
Gln Ser Ile Pro Ala Thr Gly Thr Thr His Ala Asp Tyr Phe Tyr Gly
    110                 115                 120
 
act att cca tgt act aga aaa atg act gat gct gaa att aat ggt gaa   434
Thr Ile Pro Cys Thr Arg Lys Met Thr Asp Ala Glu Ile Asn Gly Glu
125                 130                 135                 140
 
tat gaa tgg gaa act ggt aat gta att gtt gaa act ttt gaa aaa caa   482
Tyr Glu Trp Glu Thr Gly Asn Val Ile Val Glu Thr Phe Glu Lys Gln
                145                 150                 155
 
gga att gat gct gct caa atg cca ggt gtt ttg gtt cat tct cat ggt   530
Gly Ile Asp Ala Ala Gln Met Pro Gly Val Leu Val His Ser His Gly
            160                 165                 170
 
cct ttt gct tgg ggt aaa aat gct gaa gat gct gtt cat aat gct att   578
Pro Phe Ala Trp Gly Lys Asn Ala Glu Asp Ala Val His Asn Ala Ile
        175                 180                 185
 
gtt ttg gaa gaa gtt gct tat atg gga att ttc tgt aga caa ttg gct   626
Val Leu Glu Glu Val Ala Tyr Met Gly Ile Phe Cys Arg Gln Leu Ala
    190                 195                 200
 
cca caa ttg cca gat atg caa caa aca ttg tta aat aaa cat tat ttg   674
Pro Gln Leu Pro Asp Met Gln Gln Thr Leu Leu Asn Lys His Tyr Leu
205                 210                 215                 220
 
aga aaa cat ggt gct aaa gca tat tat ggt caa actagtcgat gcct       721
Arg Lys His Gly Ala Lys Ala Tyr Tyr Gly Gln
                225                 230
 

<210> 248
<211> 231
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in S. cerevisiae

<400> 248
Met Leu Glu Asp Leu Lys Arg Gln Val Leu Glu Ala Asn Leu Ala Leu
 1               5                  10                  15      
Pro Lys His Asn Leu Val Thr Leu Thr Trp Gly Asn Val Ser Ala Val
            20                  25                  30          
Asp Arg Glu Arg Gly Val Phe Val Ile Lys Pro Ser Gly Val Asp Tyr
        35                  40                  45              
Ser Ile Met Thr Ala Asp Asp Met Val Val Val Ser Ile Glu Thr Gly
    50                  55                  60                  
Glu Val Val Glu Gly Ala Lys Lys Pro Ser Ser Asp Thr Pro Thr His
65                  70                  75                  80  
Arg Leu Leu Tyr Gln Ala Phe Pro Ser Ile Gly Gly Ile Val His Thr
                85                  90                  95      
His Ser Arg His Ala Thr Ile Trp Ala Gln Ala Gly Gln Ser Ile Pro
            100                 105                 110         
Ala Thr Gly Thr Thr His Ala Asp Tyr Phe Tyr Gly Thr Ile Pro Cys
        115                 120                 125             
Thr Arg Lys Met Thr Asp Ala Glu Ile Asn Gly Glu Tyr Glu Trp Glu
    130                 135                 140                 
Thr Gly Asn Val Ile Val Glu Thr Phe Glu Lys Gln Gly Ile Asp Ala
145                 150                 155                 160 
Ala Gln Met Pro Gly Val Leu Val His Ser His Gly Pro Phe Ala Trp
                165                 170                 175     
Gly Lys Asn Ala Glu Asp Ala Val His Asn Ala Ile Val Leu Glu Glu
            180                 185                 190         
Val Ala Tyr Met Gly Ile Phe Cys Arg Gln Leu Ala Pro Gln Leu Pro
        195                 200                 205             
Asp Met Gln Gln Thr Leu Leu Asn Lys His Tyr Leu Arg Lys His Gly
    210                 215                 220                 
Ala Lys Ala Tyr Tyr Gly Gln
225                 230     


<210> 249
<211> 693
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in E. coli

<220> 
<221> CDS            
<222> (1)...(693)

<400> 249
atg ttg gaa gat tta aaa aga caa gtt ttg gaa gca aat ttg gcg ttg   48
Met Leu Glu Asp Leu Lys Arg Gln Val Leu Glu Ala Asn Leu Ala Leu
 1               5                   10                  15
 
cct aaa cat aat ttg gtt aca ttg act tgg ggt aat gtt tca gct gtt   96
Pro Lys His Asn Leu Val Thr Leu Thr Trp Gly Asn Val Ser Ala Val
             20                  25                  30
 
gat aga gaa aga ggt gtt ttt gta att aaa cca tct ggt gtt gat tat   144
Asp Arg Glu Arg Gly Val Phe Val Ile Lys Pro Ser Gly Val Asp Tyr
         35                  40                  45
 
agt att atg act gct gat gat atg gtt gtt gtt tcc att gaa act gga   192
Ser Ile Met Thr Ala Asp Asp Met Val Val Val Ser Ile Glu Thr Gly
     50                  55                  60
 
gaa gtt gtt gaa ggt gct aaa aag cca tct tct gat act cca act cat   240
Glu Val Val Glu Gly Ala Lys Lys Pro Ser Ser Asp Thr Pro Thr His
 65                  70                  75                  80
 
aga ttg ttg tat caa gca ttt cca tct att ggt gga att gtt cat act   288
Arg Leu Leu Tyr Gln Ala Phe Pro Ser Ile Gly Gly Ile Val His Thr
                 85                  90                  95
 
cat tct aga cat gct aca att tgg gct caa gct ggt caa tct att cct   336
His Ser Arg His Ala Thr Ile Trp Ala Gln Ala Gly Gln Ser Ile Pro
            100                 105                 110
 
gca act ggt act act cat gct gat tat ttt tat ggt act att cca tgt   384
Ala Thr Gly Thr Thr His Ala Asp Tyr Phe Tyr Gly Thr Ile Pro Cys
        115                 120                 125
 
act aga aaa atg act gat gct gaa att aat ggt gaa tat gaa tgg gaa   432
Thr Arg Lys Met Thr Asp Ala Glu Ile Asn Gly Glu Tyr Glu Trp Glu
    130                 135                 140
 
act ggt aat gta att gtt gaa act ttt gaa aaa caa gga att gat gct   480
Thr Gly Asn Val Ile Val Glu Thr Phe Glu Lys Gln Gly Ile Asp Ala
145                 150                 155                 160
 
gct caa atg cca ggt gtt ttg gtt cat tct cat ggt cct ttt gct tgg   528
Ala Gln Met Pro Gly Val Leu Val His Ser His Gly Pro Phe Ala Trp
                165                 170                 175
 
ggt aaa aat gct gaa gat gct gtt cat aat gct att gtt ttg gaa gaa   576
Gly Lys Asn Ala Glu Asp Ala Val His Asn Ala Ile Val Leu Glu Glu
            180                 185                 190
 
gtt gct tat atg gga att ttc tgt aga caa ttg gct cca caa ttg cca   624
Val Ala Tyr Met Gly Ile Phe Cys Arg Gln Leu Ala Pro Gln Leu Pro
        195                 200                 205
 
gat atg caa caa aca ttg tta aat aaa cat tat ttg aga aaa cat ggt   672
Asp Met Gln Gln Thr Leu Leu Asn Lys His Tyr Leu Arg Lys His Gly
    210                 215                 220
 
gct aaa gca tat tat ggt caa                                       693
Ala Lys Ala Tyr Tyr Gly Gln
225                 230
 

<210> 250
<211> 231
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in E. coli

<400> 250
Met Leu Glu Asp Leu Lys Arg Gln Val Leu Glu Ala Asn Leu Ala Leu
 1               5                  10                  15      
Pro Lys His Asn Leu Val Thr Leu Thr Trp Gly Asn Val Ser Ala Val
            20                  25                  30          
Asp Arg Glu Arg Gly Val Phe Val Ile Lys Pro Ser Gly Val Asp Tyr
        35                  40                  45              
Ser Ile Met Thr Ala Asp Asp Met Val Val Val Ser Ile Glu Thr Gly
    50                  55                  60                  
Glu Val Val Glu Gly Ala Lys Lys Pro Ser Ser Asp Thr Pro Thr His
65                  70                  75                  80  
Arg Leu Leu Tyr Gln Ala Phe Pro Ser Ile Gly Gly Ile Val His Thr
                85                  90                  95      
His Ser Arg His Ala Thr Ile Trp Ala Gln Ala Gly Gln Ser Ile Pro
            100                 105                 110         
Ala Thr Gly Thr Thr His Ala Asp Tyr Phe Tyr Gly Thr Ile Pro Cys
        115                 120                 125             
Thr Arg Lys Met Thr Asp Ala Glu Ile Asn Gly Glu Tyr Glu Trp Glu
    130                 135                 140                 
Thr Gly Asn Val Ile Val Glu Thr Phe Glu Lys Gln Gly Ile Asp Ala
145                 150                 155                 160 
Ala Gln Met Pro Gly Val Leu Val His Ser His Gly Pro Phe Ala Trp
                165                 170                 175     
Gly Lys Asn Ala Glu Asp Ala Val His Asn Ala Ile Val Leu Glu Glu
            180                 185                 190         
Val Ala Tyr Met Gly Ile Phe Cys Arg Gln Leu Ala Pro Gln Leu Pro
        195                 200                 205             
Asp Met Gln Gln Thr Leu Leu Asn Lys His Tyr Leu Arg Lys His Gly
    210                 215                 220                 
Ala Lys Ala Tyr Tyr Gly Gln
225                 230     


<210> 251
<211> 715
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in E. coli

<220> 
<221> CDS            
<222> (12)...(704)

<400> 251
tactcaagct t atg ttg gaa gat tta aaa aga caa gtt ttg gaa gca aat  50
             Met Leu Glu Asp Leu Lys Arg Gln Val Leu Glu Ala Asn
              1               5                   10
 
ttg gcg ttg cct aaa cat aat ttg gtt aca ttg act tgg ggt aat gtt   98
Leu Ala Leu Pro Lys His Asn Leu Val Thr Leu Thr Trp Gly Asn Val
     15                  20                  25
 
tca gct gtt gat aga gaa aga ggt gtt ttt gta att aaa cca tct ggt   146
Ser Ala Val Asp Arg Glu Arg Gly Val Phe Val Ile Lys Pro Ser Gly
 30                  35                  40                  45
 
gtt gat tat agt att atg act gct gat gat atg gtt gtt gtt tcc att   194
Val Asp Tyr Ser Ile Met Thr Ala Asp Asp Met Val Val Val Ser Ile
                 50                  55                  60
 
gaa act gga gaa gtt gtt gaa ggt gct aaa aag cca tct tct gat act   242
Glu Thr Gly Glu Val Val Glu Gly Ala Lys Lys Pro Ser Ser Asp Thr
             65                  70                  75
 
cca act cat aga ttg ttg tat caa gca ttt cca tct att ggt gga att   290
Pro Thr His Arg Leu Leu Tyr Gln Ala Phe Pro Ser Ile Gly Gly Ile
         80                  85                  90
 
gtt cat act cat tct aga cat gct aca att tgg gct caa gct ggt caa   338
Val His Thr His Ser Arg His Ala Thr Ile Trp Ala Gln Ala Gly Gln
     95                 100                 105
 
tct att cct gca act ggt act act cat gct gat tat ttt tat ggt act   386
Ser Ile Pro Ala Thr Gly Thr Thr His Ala Asp Tyr Phe Tyr Gly Thr
110                 115                 120                 125
 
att cca tgt act aga aaa atg act gat gct gaa att aat ggt gaa tat   434
Ile Pro Cys Thr Arg Lys Met Thr Asp Ala Glu Ile Asn Gly Glu Tyr
                130                 135                 140
 
gaa tgg gaa act ggt aat gta att gtt gaa act ttt gaa aaa caa gga   482
Glu Trp Glu Thr Gly Asn Val Ile Val Glu Thr Phe Glu Lys Gln Gly
            145                 150                 155
 
att gat gct gct caa atg cca ggt gtt ttg gtt cat tct cat ggt cct   530
Ile Asp Ala Ala Gln Met Pro Gly Val Leu Val His Ser His Gly Pro
        160                 165                 170
 
ttt gct tgg ggt aaa aat gct gaa gat gct gtt cat aat gct att gtt   578
Phe Ala Trp Gly Lys Asn Ala Glu Asp Ala Val His Asn Ala Ile Val
    175                 180                 185
 
ttg gaa gaa gtt gct tat atg gga att ttc tgt aga caa ttg gct cca   626
Leu Glu Glu Val Ala Tyr Met Gly Ile Phe Cys Arg Gln Leu Ala Pro
190                 195                 200                 205
 
caa ttg cca gat atg caa caa aca ttg tta aat aaa cat tat ttg aga   674
Gln Leu Pro Asp Met Gln Gln Thr Leu Leu Asn Lys His Tyr Leu Arg
                210                 215                 220
 
aaa cat ggt gct aaa gca tat tat ggt caa gaattccgat g              715
Lys His Gly Ala Lys Ala Tyr Tyr Gly Gln
            225                 230
 

<210> 252
<211> 231
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in E. coli

<400> 252
Met Leu Glu Asp Leu Lys Arg Gln Val Leu Glu Ala Asn Leu Ala Leu
 1               5                  10                  15      
Pro Lys His Asn Leu Val Thr Leu Thr Trp Gly Asn Val Ser Ala Val
            20                  25                  30          
Asp Arg Glu Arg Gly Val Phe Val Ile Lys Pro Ser Gly Val Asp Tyr
        35                  40                  45              
Ser Ile Met Thr Ala Asp Asp Met Val Val Val Ser Ile Glu Thr Gly
    50                  55                  60                  
Glu Val Val Glu Gly Ala Lys Lys Pro Ser Ser Asp Thr Pro Thr His
65                  70                  75                  80  
Arg Leu Leu Tyr Gln Ala Phe Pro Ser Ile Gly Gly Ile Val His Thr
                85                  90                  95      
His Ser Arg His Ala Thr Ile Trp Ala Gln Ala Gly Gln Ser Ile Pro
            100                 105                 110         
Ala Thr Gly Thr Thr His Ala Asp Tyr Phe Tyr Gly Thr Ile Pro Cys
        115                 120                 125             
Thr Arg Lys Met Thr Asp Ala Glu Ile Asn Gly Glu Tyr Glu Trp Glu
    130                 135                 140                 
Thr Gly Asn Val Ile Val Glu Thr Phe Glu Lys Gln Gly Ile Asp Ala
145                 150                 155                 160 
Ala Gln Met Pro Gly Val Leu Val His Ser His Gly Pro Phe Ala Trp
                165                 170                 175     
Gly Lys Asn Ala Glu Asp Ala Val His Asn Ala Ile Val Leu Glu Glu
            180                 185                 190         
Val Ala Tyr Met Gly Ile Phe Cys Arg Gln Leu Ala Pro Gln Leu Pro
        195                 200                 205             
Asp Met Gln Gln Thr Leu Leu Asn Lys His Tyr Leu Arg Lys His Gly
    210                 215                 220                 
Ala Lys Ala Tyr Tyr Gly Gln
225                 230     


<210> 253
<211> 721
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in E. coli

<220> 
<221> CDS            
<222> (15)...(707)

<400> 253
gaatactcca tatg atg ttg gaa gat tta aaa aga caa gtt ttg gaa gca   50
                Met Leu Glu Asp Leu Lys Arg Gln Val Leu Glu Ala
                 1               5                   10
 
aat ttg gcg ttg cct aaa cat aat ttg gtt aca ttg act tgg ggt aat   98
Asn Leu Ala Leu Pro Lys His Asn Leu Val Thr Leu Thr Trp Gly Asn
         15                  20                  25
 
gtt tca gct gtt gat aga gaa aga ggt gtt ttt gta att aaa cca tct   146
Val Ser Ala Val Asp Arg Glu Arg Gly Val Phe Val Ile Lys Pro Ser
     30                  35                  40
 
ggt gtt gat tat agt att atg act gct gat gat atg gtt gtt gtt tcc   194
Gly Val Asp Tyr Ser Ile Met Thr Ala Asp Asp Met Val Val Val Ser
 45                  50                  55                  60
 
att gaa act gga gaa gtt gtt gaa ggt gct aaa aag cca tct tct gat   242
Ile Glu Thr Gly Glu Val Val Glu Gly Ala Lys Lys Pro Ser Ser Asp
                 65                  70                  75
 
act cca act cat aga ttg ttg tat caa gca ttt cca tct att ggt gga   290
Thr Pro Thr His Arg Leu Leu Tyr Gln Ala Phe Pro Ser Ile Gly Gly
             80                  85                  90
 
att gtt cat act cat tct aga cat gct aca att tgg gct caa gct ggt   338
Ile Val His Thr His Ser Arg His Ala Thr Ile Trp Ala Gln Ala Gly
         95                 100                 105
 
caa tct att cct gca act ggt act act cat gct gat tat ttt tat ggt   386
Gln Ser Ile Pro Ala Thr Gly Thr Thr His Ala Asp Tyr Phe Tyr Gly
    110                 115                 120
 
act att cca tgt act aga aaa atg act gat gct gaa att aat ggt gaa   434
Thr Ile Pro Cys Thr Arg Lys Met Thr Asp Ala Glu Ile Asn Gly Glu
125                 130                 135                 140
 
tat gaa tgg gaa act ggt aat gta att gtt gaa act ttt gaa aaa caa   482
Tyr Glu Trp Glu Thr Gly Asn Val Ile Val Glu Thr Phe Glu Lys Gln
                145                 150                 155
 
gga att gat gct gct caa atg cca ggt gtt ttg gtt cat tct cat ggt   530
Gly Ile Asp Ala Ala Gln Met Pro Gly Val Leu Val His Ser His Gly
            160                 165                 170
 
cct ttt gct tgg ggt aaa aat gct gaa gat gct gtt cat aat gct att   578
Pro Phe Ala Trp Gly Lys Asn Ala Glu Asp Ala Val His Asn Ala Ile
        175                 180                 185
 
gtt ttg gaa gaa gtt gct tat atg gga att ttc tgt aga caa ttg gct   626
Val Leu Glu Glu Val Ala Tyr Met Gly Ile Phe Cys Arg Gln Leu Ala
    190                 195                 200
 
cca caa ttg cca gat atg caa caa aca ttg tta aat aaa cat tat ttg   674
Pro Gln Leu Pro Asp Met Gln Gln Thr Leu Leu Asn Lys His Tyr Leu
205                 210                 215                 220
 
aga aaa cat ggt gct aaa gca tat tat ggt caa actagtcgat gcct       721
Arg Lys His Gly Ala Lys Ala Tyr Tyr Gly Gln
                225                 230
 

<210> 254
<211> 231
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in E. coli

<400> 254
Met Leu Glu Asp Leu Lys Arg Gln Val Leu Glu Ala Asn Leu Ala Leu
 1               5                  10                  15      
Pro Lys His Asn Leu Val Thr Leu Thr Trp Gly Asn Val Ser Ala Val
            20                  25                  30          
Asp Arg Glu Arg Gly Val Phe Val Ile Lys Pro Ser Gly Val Asp Tyr
        35                  40                  45              
Ser Ile Met Thr Ala Asp Asp Met Val Val Val Ser Ile Glu Thr Gly
    50                  55                  60                  
Glu Val Val Glu Gly Ala Lys Lys Pro Ser Ser Asp Thr Pro Thr His
65                  70                  75                  80  
Arg Leu Leu Tyr Gln Ala Phe Pro Ser Ile Gly Gly Ile Val His Thr
                85                  90                  95      
His Ser Arg His Ala Thr Ile Trp Ala Gln Ala Gly Gln Ser Ile Pro
            100                 105                 110         
Ala Thr Gly Thr Thr His Ala Asp Tyr Phe Tyr Gly Thr Ile Pro Cys
        115                 120                 125             
Thr Arg Lys Met Thr Asp Ala Glu Ile Asn Gly Glu Tyr Glu Trp Glu
    130                 135                 140                 
Thr Gly Asn Val Ile Val Glu Thr Phe Glu Lys Gln Gly Ile Asp Ala
145                 150                 155                 160 
Ala Gln Met Pro Gly Val Leu Val His Ser His Gly Pro Phe Ala Trp
                165                 170                 175     
Gly Lys Asn Ala Glu Asp Ala Val His Asn Ala Ile Val Leu Glu Glu
            180                 185                 190         
Val Ala Tyr Met Gly Ile Phe Cys Arg Gln Leu Ala Pro Gln Leu Pro
        195                 200                 205             
Asp Met Gln Gln Thr Leu Leu Asn Lys His Tyr Leu Arg Lys His Gly
    210                 215                 220                 
Ala Lys Ala Tyr Tyr Gly Gln
225                 230     


<210> 255
<211> 693
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in P. pastoris

<220> 
<221> CDS            
<222> (1)...(693)

<400> 255
atg tta gaa gat tta aaa aga caa gtt tta gaa gct aat ttg gca tta   48
Met Leu Glu Asp Leu Lys Arg Gln Val Leu Glu Ala Asn Leu Ala Leu
 1               5                   10                  15
 
cct aaa cat aat ttg gtt act tta act tgg gga aat gtt tct gct gtg   96
Pro Lys His Asn Leu Val Thr Leu Thr Trp Gly Asn Val Ser Ala Val
             20                  25                  30
 
gat aga gaa aga gga gtt ttt gtt att aaa cct tct gga gtt gat tat   144
Asp Arg Glu Arg Gly Val Phe Val Ile Lys Pro Ser Gly Val Asp Tyr
         35                  40                  45
 
tct att atg aca gct gat gat atg gtt gtt gtg tct att gaa act gga   192
Ser Ile Met Thr Ala Asp Asp Met Val Val Val Ser Ile Glu Thr Gly
     50                  55                  60
 
gaa gtt gtt gaa gga gct aaa aag cca tct tct gat act cca act cat   240
Glu Val Val Glu Gly Ala Lys Lys Pro Ser Ser Asp Thr Pro Thr His
 65                  70                  75                  80
 
aga ttg ttg tat cag gct ttt cca tct att gga gga att gtt cat act   288
Arg Leu Leu Tyr Gln Ala Phe Pro Ser Ile Gly Gly Ile Val His Thr
                 85                  90                  95
 
cat tct aga cat gct act att tgg gct cag gca gga caa tct atc cca   336
His Ser Arg His Ala Thr Ile Trp Ala Gln Ala Gly Gln Ser Ile Pro
            100                 105                 110
 
gct aca ggt act act cat gct gat tat ttt tat ggt act att cca tgt   384
Ala Thr Gly Thr Thr His Ala Asp Tyr Phe Tyr Gly Thr Ile Pro Cys
        115                 120                 125
 
act aga aaa atg act gat gct gaa att aat gga gaa tat gaa tgg gaa   432
Thr Arg Lys Met Thr Asp Ala Glu Ile Asn Gly Glu Tyr Glu Trp Glu
    130                 135                 140
 
act gga aat gtt att gtt gaa act ttt gag aaa caa gga att gac gct   480
Thr Gly Asn Val Ile Val Glu Thr Phe Glu Lys Gln Gly Ile Asp Ala
145                 150                 155                 160
 
gct caa atg cct ggt gtt ttg gtt cat tct cat gga cct ttt gca tgg   528
Ala Gln Met Pro Gly Val Leu Val His Ser His Gly Pro Phe Ala Trp
                165                 170                 175
 
ggt aaa aac gct gaa gat gct gtt cat aat gca att gtt tta gaa gaa   576
Gly Lys Asn Ala Glu Asp Ala Val His Asn Ala Ile Val Leu Glu Glu
            180                 185                 190
 
gtt gct tat atg gga att ttc tgt aga caa ttg gct cca caa tta cca   624
Val Ala Tyr Met Gly Ile Phe Cys Arg Gln Leu Ala Pro Gln Leu Pro
        195                 200                 205
 
gat atg caa caa act tta tta aat aaa cat tat ttg aga aaa cat gga   672
Asp Met Gln Gln Thr Leu Leu Asn Lys His Tyr Leu Arg Lys His Gly
    210                 215                 220
 
gct aaa gca tat tat gga caa                                       693
Ala Lys Ala Tyr Tyr Gly Gln
225                 230
 

<210> 256
<211> 231
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in P. pastoris

<400> 256
Met Leu Glu Asp Leu Lys Arg Gln Val Leu Glu Ala Asn Leu Ala Leu
 1               5                  10                  15      
Pro Lys His Asn Leu Val Thr Leu Thr Trp Gly Asn Val Ser Ala Val
            20                  25                  30          
Asp Arg Glu Arg Gly Val Phe Val Ile Lys Pro Ser Gly Val Asp Tyr
        35                  40                  45              
Ser Ile Met Thr Ala Asp Asp Met Val Val Val Ser Ile Glu Thr Gly
    50                  55                  60                  
Glu Val Val Glu Gly Ala Lys Lys Pro Ser Ser Asp Thr Pro Thr His
65                  70                  75                  80  
Arg Leu Leu Tyr Gln Ala Phe Pro Ser Ile Gly Gly Ile Val His Thr
                85                  90                  95      
His Ser Arg His Ala Thr Ile Trp Ala Gln Ala Gly Gln Ser Ile Pro
            100                 105                 110         
Ala Thr Gly Thr Thr His Ala Asp Tyr Phe Tyr Gly Thr Ile Pro Cys
        115                 120                 125             
Thr Arg Lys Met Thr Asp Ala Glu Ile Asn Gly Glu Tyr Glu Trp Glu
    130                 135                 140                 
Thr Gly Asn Val Ile Val Glu Thr Phe Glu Lys Gln Gly Ile Asp Ala
145                 150                 155                 160 
Ala Gln Met Pro Gly Val Leu Val His Ser His Gly Pro Phe Ala Trp
                165                 170                 175     
Gly Lys Asn Ala Glu Asp Ala Val His Asn Ala Ile Val Leu Glu Glu
            180                 185                 190         
Val Ala Tyr Met Gly Ile Phe Cys Arg Gln Leu Ala Pro Gln Leu Pro
        195                 200                 205             
Asp Met Gln Gln Thr Leu Leu Asn Lys His Tyr Leu Arg Lys His Gly
    210                 215                 220                 
Ala Lys Ala Tyr Tyr Gly Gln
225                 230     


<210> 257
<211> 715
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in P. pastoris

<220> 
<221> CDS            
<222> (12)...(704)

<400> 257
tactcaagct t atg tta gaa gat tta aaa aga caa gtt tta gaa gct aat  50
             Met Leu Glu Asp Leu Lys Arg Gln Val Leu Glu Ala Asn
              1               5                   10
 
ttg gca tta cct aaa cat aat ttg gtt act tta act tgg gga aat gtt   98
Leu Ala Leu Pro Lys His Asn Leu Val Thr Leu Thr Trp Gly Asn Val
     15                  20                  25
 
tct gct gtg gat aga gaa aga gga gtt ttt gtt att aaa cct tct gga   146
Ser Ala Val Asp Arg Glu Arg Gly Val Phe Val Ile Lys Pro Ser Gly
 30                  35                  40                  45
 
gtt gat tat tct att atg aca gct gat gat atg gtt gtt gtg tct att   194
Val Asp Tyr Ser Ile Met Thr Ala Asp Asp Met Val Val Val Ser Ile
                 50                  55                  60
 
gaa act gga gaa gtt gtt gaa gga gct aaa aag cca tct tct gat act   242
Glu Thr Gly Glu Val Val Glu Gly Ala Lys Lys Pro Ser Ser Asp Thr
             65                  70                  75
 
cca act cat aga ttg ttg tat cag gct ttt cca tct att gga gga att   290
Pro Thr His Arg Leu Leu Tyr Gln Ala Phe Pro Ser Ile Gly Gly Ile
         80                  85                  90
 
gtt cat act cat tct aga cat gct act att tgg gct cag gca gga caa   338
Val His Thr His Ser Arg His Ala Thr Ile Trp Ala Gln Ala Gly Gln
     95                 100                 105
 
tct atc cca gct aca ggt act act cat gct gat tat ttt tat ggt act   386
Ser Ile Pro Ala Thr Gly Thr Thr His Ala Asp Tyr Phe Tyr Gly Thr
110                 115                 120                 125
 
att cca tgt act aga aaa atg act gat gct gaa att aat gga gaa tat   434
Ile Pro Cys Thr Arg Lys Met Thr Asp Ala Glu Ile Asn Gly Glu Tyr
                130                 135                 140
 
gaa tgg gaa act gga aat gtt att gtt gaa act ttt gag aaa caa gga   482
Glu Trp Glu Thr Gly Asn Val Ile Val Glu Thr Phe Glu Lys Gln Gly
            145                 150                 155
 
att gac gct gct caa atg cct ggt gtt ttg gtt cat tct cat gga cct   530
Ile Asp Ala Ala Gln Met Pro Gly Val Leu Val His Ser His Gly Pro
        160                 165                 170
 
ttt gca tgg ggt aaa aac gct gaa gat gct gtt cat aat gca att gtt   578
Phe Ala Trp Gly Lys Asn Ala Glu Asp Ala Val His Asn Ala Ile Val
    175                 180                 185
 
tta gaa gaa gtt gct tat atg gga att ttc tgt aga caa ttg gct cca   626
Leu Glu Glu Val Ala Tyr Met Gly Ile Phe Cys Arg Gln Leu Ala Pro
190                 195                 200                 205
 
caa tta cca gat atg caa caa act tta tta aat aaa cat tat ttg aga   674
Gln Leu Pro Asp Met Gln Gln Thr Leu Leu Asn Lys His Tyr Leu Arg
                210                 215                 220
 
aaa cat gga gct aaa gca tat tat gga caa gaattccgat g              715
Lys His Gly Ala Lys Ala Tyr Tyr Gly Gln
            225                 230
 

<210> 258
<211> 231
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in P. pastoris

<400> 258
Met Leu Glu Asp Leu Lys Arg Gln Val Leu Glu Ala Asn Leu Ala Leu
 1               5                  10                  15      
Pro Lys His Asn Leu Val Thr Leu Thr Trp Gly Asn Val Ser Ala Val
            20                  25                  30          
Asp Arg Glu Arg Gly Val Phe Val Ile Lys Pro Ser Gly Val Asp Tyr
        35                  40                  45              
Ser Ile Met Thr Ala Asp Asp Met Val Val Val Ser Ile Glu Thr Gly
    50                  55                  60                  
Glu Val Val Glu Gly Ala Lys Lys Pro Ser Ser Asp Thr Pro Thr His
65                  70                  75                  80  
Arg Leu Leu Tyr Gln Ala Phe Pro Ser Ile Gly Gly Ile Val His Thr
                85                  90                  95      
His Ser Arg His Ala Thr Ile Trp Ala Gln Ala Gly Gln Ser Ile Pro
            100                 105                 110         
Ala Thr Gly Thr Thr His Ala Asp Tyr Phe Tyr Gly Thr Ile Pro Cys
        115                 120                 125             
Thr Arg Lys Met Thr Asp Ala Glu Ile Asn Gly Glu Tyr Glu Trp Glu
    130                 135                 140                 
Thr Gly Asn Val Ile Val Glu Thr Phe Glu Lys Gln Gly Ile Asp Ala
145                 150                 155                 160 
Ala Gln Met Pro Gly Val Leu Val His Ser His Gly Pro Phe Ala Trp
                165                 170                 175     
Gly Lys Asn Ala Glu Asp Ala Val His Asn Ala Ile Val Leu Glu Glu
            180                 185                 190         
Val Ala Tyr Met Gly Ile Phe Cys Arg Gln Leu Ala Pro Gln Leu Pro
        195                 200                 205             
Asp Met Gln Gln Thr Leu Leu Asn Lys His Tyr Leu Arg Lys His Gly
    210                 215                 220                 
Ala Lys Ala Tyr Tyr Gly Gln
225                 230     


<210> 259
<211> 721
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in P. pastoris

<220> 
<221> CDS            
<222> (15)...(707)

<400> 259
gaatactcca tatg atg tta gaa gat tta aaa aga caa gtt tta gaa gct   50
                Met Leu Glu Asp Leu Lys Arg Gln Val Leu Glu Ala
                 1               5                   10
 
aat ttg gca tta cct aaa cat aat ttg gtt act tta act tgg gga aat   98
Asn Leu Ala Leu Pro Lys His Asn Leu Val Thr Leu Thr Trp Gly Asn
         15                  20                  25
 
gtt tct gct gtg gat aga gaa aga gga gtt ttt gtt att aaa cct tct   146
Val Ser Ala Val Asp Arg Glu Arg Gly Val Phe Val Ile Lys Pro Ser
     30                  35                  40
 
gga gtt gat tat tct att atg aca gct gat gat atg gtt gtt gtg tct   194
Gly Val Asp Tyr Ser Ile Met Thr Ala Asp Asp Met Val Val Val Ser
 45                  50                  55                  60
 
att gaa act gga gaa gtt gtt gaa gga gct aaa aag cca tct tct gat   242
Ile Glu Thr Gly Glu Val Val Glu Gly Ala Lys Lys Pro Ser Ser Asp
                 65                  70                  75
 
act cca act cat aga ttg ttg tat cag gct ttt cca tct att gga gga   290
Thr Pro Thr His Arg Leu Leu Tyr Gln Ala Phe Pro Ser Ile Gly Gly
             80                  85                  90
 
att gtt cat act cat tct aga cat gct act att tgg gct cag gca gga   338
Ile Val His Thr His Ser Arg His Ala Thr Ile Trp Ala Gln Ala Gly
         95                 100                 105
 
caa tct atc cca gct aca ggt act act cat gct gat tat ttt tat ggt   386
Gln Ser Ile Pro Ala Thr Gly Thr Thr His Ala Asp Tyr Phe Tyr Gly
    110                 115                 120
 
act att cca tgt act aga aaa atg act gat gct gaa att aat gga gaa   434
Thr Ile Pro Cys Thr Arg Lys Met Thr Asp Ala Glu Ile Asn Gly Glu
125                 130                 135                 140
 
tat gaa tgg gaa act gga aat gtt att gtt gaa act ttt gag aaa caa   482
Tyr Glu Trp Glu Thr Gly Asn Val Ile Val Glu Thr Phe Glu Lys Gln
                145                 150                 155
 
gga att gac gct gct caa atg cct ggt gtt ttg gtt cat tct cat gga   530
Gly Ile Asp Ala Ala Gln Met Pro Gly Val Leu Val His Ser His Gly
            160                 165                 170
 
cct ttt gca tgg ggt aaa aac gct gaa gat gct gtt cat aat gca att   578
Pro Phe Ala Trp Gly Lys Asn Ala Glu Asp Ala Val His Asn Ala Ile
        175                 180                 185
 
gtt tta gaa gaa gtt gct tat atg gga att ttc tgt aga caa ttg gct   626
Val Leu Glu Glu Val Ala Tyr Met Gly Ile Phe Cys Arg Gln Leu Ala
    190                 195                 200
 
cca caa tta cca gat atg caa caa act tta tta aat aaa cat tat ttg   674
Pro Gln Leu Pro Asp Met Gln Gln Thr Leu Leu Asn Lys His Tyr Leu
205                 210                 215                 220
 
aga aaa cat gga gct aaa gca tat tat gga caa actagtcgat gcct       721
Arg Lys His Gly Ala Lys Ala Tyr Tyr Gly Gln
                225                 230
 

<210> 260
<211> 231
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in P. pastoris

<400> 260
Met Leu Glu Asp Leu Lys Arg Gln Val Leu Glu Ala Asn Leu Ala Leu
 1               5                  10                  15      
Pro Lys His Asn Leu Val Thr Leu Thr Trp Gly Asn Val Ser Ala Val
            20                  25                  30          
Asp Arg Glu Arg Gly Val Phe Val Ile Lys Pro Ser Gly Val Asp Tyr
        35                  40                  45              
Ser Ile Met Thr Ala Asp Asp Met Val Val Val Ser Ile Glu Thr Gly
    50                  55                  60                  
Glu Val Val Glu Gly Ala Lys Lys Pro Ser Ser Asp Thr Pro Thr His
65                  70                  75                  80  
Arg Leu Leu Tyr Gln Ala Phe Pro Ser Ile Gly Gly Ile Val His Thr
                85                  90                  95      
His Ser Arg His Ala Thr Ile Trp Ala Gln Ala Gly Gln Ser Ile Pro
            100                 105                 110         
Ala Thr Gly Thr Thr His Ala Asp Tyr Phe Tyr Gly Thr Ile Pro Cys
        115                 120                 125             
Thr Arg Lys Met Thr Asp Ala Glu Ile Asn Gly Glu Tyr Glu Trp Glu
    130                 135                 140                 
Thr Gly Asn Val Ile Val Glu Thr Phe Glu Lys Gln Gly Ile Asp Ala
145                 150                 155                 160 
Ala Gln Met Pro Gly Val Leu Val His Ser His Gly Pro Phe Ala Trp
                165                 170                 175     
Gly Lys Asn Ala Glu Asp Ala Val His Asn Ala Ile Val Leu Glu Glu
            180                 185                 190         
Val Ala Tyr Met Gly Ile Phe Cys Arg Gln Leu Ala Pro Gln Leu Pro
        195                 200                 205             
Asp Met Gln Gln Thr Leu Leu Asn Lys His Tyr Leu Arg Lys His Gly
    210                 215                 220                 
Ala Lys Ala Tyr Tyr Gly Gln
225                 230     


<210> 261
<211> 693
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in K. lactis

<220> 
<221> CDS            
<222> (1)...(693)

<400> 261
atg ttg gaa gat tta aaa aga caa gtt ttg gaa gct aat ttg gct ttg   48
Met Leu Glu Asp Leu Lys Arg Gln Val Leu Glu Ala Asn Leu Ala Leu
 1               5                   10                  15
 
cca aaa cat aat ttg gtt aca ttg act tgg ggt aat gtt tct gct gtt   96
Pro Lys His Asn Leu Val Thr Leu Thr Trp Gly Asn Val Ser Ala Val
             20                  25                  30
 
gat aga gaa aga ggt gtt ttc gtt att aaa cca tct ggt gtt gac tat   144
Asp Arg Glu Arg Gly Val Phe Val Ile Lys Pro Ser Gly Val Asp Tyr
         35                  40                  45
 
tct att atg act gct gat gat atg gtt gtt gtt tct att gaa act ggt   192
Ser Ile Met Thr Ala Asp Asp Met Val Val Val Ser Ile Glu Thr Gly
     50                  55                  60
 
gaa gtt gtt gaa ggt gct aaa aag cca tct tct gat act cca act cat   240
Glu Val Val Glu Gly Ala Lys Lys Pro Ser Ser Asp Thr Pro Thr His
 65                  70                  75                  80
 
aga ttg ttg tat caa gca ttc cct tct att ggt gga att gtt cat act   288
Arg Leu Leu Tyr Gln Ala Phe Pro Ser Ile Gly Gly Ile Val His Thr
                 85                  90                  95
 
cat tct agg cat gct act att tgg gct caa gct ggt caa tct att cca   336
His Ser Arg His Ala Thr Ile Trp Ala Gln Ala Gly Gln Ser Ile Pro
            100                 105                 110
 
gcc act gga act act cat gct gat tac ttc tat ggt aca att cca tgt   384
Ala Thr Gly Thr Thr His Ala Asp Tyr Phe Tyr Gly Thr Ile Pro Cys
        115                 120                 125
 
act aga aaa atg act gat gct gaa att aat ggt gaa tat gaa tgg gaa   432
Thr Arg Lys Met Thr Asp Ala Glu Ile Asn Gly Glu Tyr Glu Trp Glu
    130                 135                 140
 
act ggt aat gtt att gtt gaa act ttc gaa aaa caa gga att gat gct   480
Thr Gly Asn Val Ile Val Glu Thr Phe Glu Lys Gln Gly Ile Asp Ala
145                 150                 155                 160
 
gct caa atg cca ggt gtt ttg gtt cat tct cat ggt cca ttc gcg tgg   528
Ala Gln Met Pro Gly Val Leu Val His Ser His Gly Pro Phe Ala Trp
                165                 170                 175
 
gga aag aat gct gaa gat gct gtt cat aat gct att gtt ctt gag gaa   576
Gly Lys Asn Ala Glu Asp Ala Val His Asn Ala Ile Val Leu Glu Glu
            180                 185                 190
 
gtt gct tat atg gga att ttc tgt aga caa ttg gct cca caa ttg cca   624
Val Ala Tyr Met Gly Ile Phe Cys Arg Gln Leu Ala Pro Gln Leu Pro
        195                 200                 205
 
gat atg caa caa aca ttg tta aat aaa cat tac ttg aga aaa cat ggt   672
Asp Met Gln Gln Thr Leu Leu Asn Lys His Tyr Leu Arg Lys His Gly
    210                 215                 220
 
gct aag gct tat tat ggt caa                                       693
Ala Lys Ala Tyr Tyr Gly Gln
225                 230
 

<210> 262
<211> 231
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in K. lactis

<400> 262
Met Leu Glu Asp Leu Lys Arg Gln Val Leu Glu Ala Asn Leu Ala Leu
 1               5                  10                  15      
Pro Lys His Asn Leu Val Thr Leu Thr Trp Gly Asn Val Ser Ala Val
            20                  25                  30          
Asp Arg Glu Arg Gly Val Phe Val Ile Lys Pro Ser Gly Val Asp Tyr
        35                  40                  45              
Ser Ile Met Thr Ala Asp Asp Met Val Val Val Ser Ile Glu Thr Gly
    50                  55                  60                  
Glu Val Val Glu Gly Ala Lys Lys Pro Ser Ser Asp Thr Pro Thr His
65                  70                  75                  80  
Arg Leu Leu Tyr Gln Ala Phe Pro Ser Ile Gly Gly Ile Val His Thr
                85                  90                  95      
His Ser Arg His Ala Thr Ile Trp Ala Gln Ala Gly Gln Ser Ile Pro
            100                 105                 110         
Ala Thr Gly Thr Thr His Ala Asp Tyr Phe Tyr Gly Thr Ile Pro Cys
        115                 120                 125             
Thr Arg Lys Met Thr Asp Ala Glu Ile Asn Gly Glu Tyr Glu Trp Glu
    130                 135                 140                 
Thr Gly Asn Val Ile Val Glu Thr Phe Glu Lys Gln Gly Ile Asp Ala
145                 150                 155                 160 
Ala Gln Met Pro Gly Val Leu Val His Ser His Gly Pro Phe Ala Trp
                165                 170                 175     
Gly Lys Asn Ala Glu Asp Ala Val His Asn Ala Ile Val Leu Glu Glu
            180                 185                 190         
Val Ala Tyr Met Gly Ile Phe Cys Arg Gln Leu Ala Pro Gln Leu Pro
        195                 200                 205             
Asp Met Gln Gln Thr Leu Leu Asn Lys His Tyr Leu Arg Lys His Gly
    210                 215                 220                 
Ala Lys Ala Tyr Tyr Gly Gln
225                 230     


<210> 263
<211> 693
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in Z. mobilis

<220> 
<221> CDS            
<222> (1)...(693)

<400> 263
atg ttg gaa gat ttg aaa cgt cag gtg ttg gaa gct aat ttg gcc ctt   48
Met Leu Glu Asp Leu Lys Arg Gln Val Leu Glu Ala Asn Leu Ala Leu
 1               5                   10                  15
 
ccg aaa cat aat ttg gtt acc ttg acc tgg ggt aat gtt tct gcc gtt   96
Pro Lys His Asn Leu Val Thr Leu Thr Trp Gly Asn Val Ser Ala Val
             20                  25                  30
 
gat cgt gaa cgt ggt gtt ttt gtc att aaa ccg tct ggt gtc gac tat   144
Asp Arg Glu Arg Gly Val Phe Val Ile Lys Pro Ser Gly Val Asp Tyr
         35                  40                  45
 
tct att atg acc gcc gat gat atg gtt gtt gtt tct att gaa acc ggt   192
Ser Ile Met Thr Ala Asp Asp Met Val Val Val Ser Ile Glu Thr Gly
     50                  55                  60
 
gaa gtt gtt gaa ggt gct aag aaa ccg tct tct gat acc ccg acg cat   240
Glu Val Val Glu Gly Ala Lys Lys Pro Ser Ser Asp Thr Pro Thr His
 65                  70                  75                  80
 
cgt ttg ttg tat cag gcc ttc ccg tct att ggt ggt ata gtt cat acg   288
Arg Leu Leu Tyr Gln Ala Phe Pro Ser Ile Gly Gly Ile Val His Thr
                 85                  90                  95
 
cat tct cgt cat gcc acc att tgg gcg cag gct ggt cag tct att ccg   336
His Ser Arg His Ala Thr Ile Trp Ala Gln Ala Gly Gln Ser Ile Pro
            100                 105                 110
 
gcc acg ggc acc acg cat gct gac tat ttt tat ggc acg atc ccg tgt   384
Ala Thr Gly Thr Thr His Ala Asp Tyr Phe Tyr Gly Thr Ile Pro Cys
        115                 120                 125
 
acc cgc aaa atg acc gat gct gaa att aat ggt gaa tat gaa tgg gaa   432
Thr Arg Lys Met Thr Asp Ala Glu Ile Asn Gly Glu Tyr Glu Trp Glu
    130                 135                 140
 
acg gga aat gtt atc gtt gaa acc ttt gaa aaa cag ggc att gat gct   480
Thr Gly Asn Val Ile Val Glu Thr Phe Glu Lys Gln Gly Ile Asp Ala
145                 150                 155                 160
 
gcc cag atg cct ggt gtt ttg gtt cat tct cat ggt ccg ttt gct tgg   528
Ala Gln Met Pro Gly Val Leu Val His Ser His Gly Pro Phe Ala Trp
                165                 170                 175
 
ggc aaa aat gct gaa gac gcc gtt cat aat gcc att gtt ttg gaa gaa   576
Gly Lys Asn Ala Glu Asp Ala Val His Asn Ala Ile Val Leu Glu Glu
            180                 185                 190
 
gtt gct tat atg ggc atc ttt tgt cgt cag ttg gcc ccg cag ttg ccg   624
Val Ala Tyr Met Gly Ile Phe Cys Arg Gln Leu Ala Pro Gln Leu Pro
        195                 200                 205
 
gat atg cag cag acc ttg ttg aat aaa cat tat ttg cgt aaa cat ggt   672
Asp Met Gln Gln Thr Leu Leu Asn Lys His Tyr Leu Arg Lys His Gly
    210                 215                 220
 
gct aag gct tat tat ggc cag                                       693
Ala Lys Ala Tyr Tyr Gly Gln
225                 230
 

<210> 264
<211> 231
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in Z. mobilis

<400> 264
Met Leu Glu Asp Leu Lys Arg Gln Val Leu Glu Ala Asn Leu Ala Leu
 1               5                  10                  15      
Pro Lys His Asn Leu Val Thr Leu Thr Trp Gly Asn Val Ser Ala Val
            20                  25                  30          
Asp Arg Glu Arg Gly Val Phe Val Ile Lys Pro Ser Gly Val Asp Tyr
        35                  40                  45              
Ser Ile Met Thr Ala Asp Asp Met Val Val Val Ser Ile Glu Thr Gly
    50                  55                  60                  
Glu Val Val Glu Gly Ala Lys Lys Pro Ser Ser Asp Thr Pro Thr His
65                  70                  75                  80  
Arg Leu Leu Tyr Gln Ala Phe Pro Ser Ile Gly Gly Ile Val His Thr
                85                  90                  95      
His Ser Arg His Ala Thr Ile Trp Ala Gln Ala Gly Gln Ser Ile Pro
            100                 105                 110         
Ala Thr Gly Thr Thr His Ala Asp Tyr Phe Tyr Gly Thr Ile Pro Cys
        115                 120                 125             
Thr Arg Lys Met Thr Asp Ala Glu Ile Asn Gly Glu Tyr Glu Trp Glu
    130                 135                 140                 
Thr Gly Asn Val Ile Val Glu Thr Phe Glu Lys Gln Gly Ile Asp Ala
145                 150                 155                 160 
Ala Gln Met Pro Gly Val Leu Val His Ser His Gly Pro Phe Ala Trp
                165                 170                 175     
Gly Lys Asn Ala Glu Asp Ala Val His Asn Ala Ile Val Leu Glu Glu
            180                 185                 190         
Val Ala Tyr Met Gly Ile Phe Cys Arg Gln Leu Ala Pro Gln Leu Pro
        195                 200                 205             
Asp Met Gln Gln Thr Leu Leu Asn Lys His Tyr Leu Arg Lys His Gly
    210                 215                 220                 
Ala Lys Ala Tyr Tyr Gly Gln
225                 230     


<210> 265
<211> 969
<212> DNA
<213> C. tenuis

<220> 
<221> CDS            
<222> (1)...(969)

<400> 265
atg agc gca agt atc cca gac atc aaa ttg agc tcc ggc cac tta atg   48
Met Ser Ala Ser Ile Pro Asp Ile Lys Leu Ser Ser Gly His Leu Met
 1               5                   10                  15
 
cct tcc atc ggt ttc ggc tgt tgg aag ctc gcc aac gct acc gcc ggt   96
Pro Ser Ile Gly Phe Gly Cys Trp Lys Leu Ala Asn Ala Thr Ala Gly
             20                  25                  30
 
gaa caa gtc tac caa gcc atc aag gcc ggt tac aga ttg ttc gac ggt   144
Glu Gln Val Tyr Gln Ala Ile Lys Ala Gly Tyr Arg Leu Phe Asp Gly
         35                  40                  45
 
gcc gag gac tac ggt aac gaa aag gaa gtc ggt gac ggt gtc aag aga   192
Ala Glu Asp Tyr Gly Asn Glu Lys Glu Val Gly Asp Gly Val Lys Arg
     50                  55                  60
 
gcc atc gac gaa ggt ctt gtc aag aga gaa gag atc ttc ctc acc tcc   240
Ala Ile Asp Glu Gly Leu Val Lys Arg Glu Glu Ile Phe Leu Thr Ser
 65                  70                  75                  80
 
aag ttg tgg aac aac tac cac gac cca aag aac gtc gag acc gcc ttg   288
Lys Leu Trp Asn Asn Tyr His Asp Pro Lys Asn Val Glu Thr Ala Leu
                 85                  90                  95
 
aac aaa acc ctc gcc gac ctt aag gtt gac tac gtt gac ttg ttc ttg   336
Asn Lys Thr Leu Ala Asp Leu Lys Val Asp Tyr Val Asp Leu Phe Leu
            100                 105                 110
 
atc cat ttc cca att gcc ttc aag ttc gtc cca atc gag gag aag tac   384
Ile His Phe Pro Ile Ala Phe Lys Phe Val Pro Ile Glu Glu Lys Tyr
        115                 120                 125
 
cca cca gga ttc tac tgt ggt gac ggt aac aac ttc gtc tac gaa gac   432
Pro Pro Gly Phe Tyr Cys Gly Asp Gly Asn Asn Phe Val Tyr Glu Asp
    130                 135                 140
 
gtt cca atc ttg gag acc tgg aag gcc ctc gag aag ttg gtt gct gcc   480
Val Pro Ile Leu Glu Thr Trp Lys Ala Leu Glu Lys Leu Val Ala Ala
145                 150                 155                 160
 
ggt aag att aag tcc atc ggt gtc tct aac ttc cca ggt gct ttg ctc   528
Gly Lys Ile Lys Ser Ile Gly Val Ser Asn Phe Pro Gly Ala Leu Leu
                165                 170                 175
 
ttg gac ttg ctc aga ggt gct acc atc aag cca gct gtc ttg caa gtt   576
Leu Asp Leu Leu Arg Gly Ala Thr Ile Lys Pro Ala Val Leu Gln Val
            180                 185                 190
 
gag cac cac cca tac ttg caa caa cca aag ttg atc gag ttc gct caa   624
Glu His His Pro Tyr Leu Gln Gln Pro Lys Leu Ile Glu Phe Ala Gln
        195                 200                 205
 
aag gcc ggt gtt acc atc acc gcc tac tct tct ttc ggt cct caa tct   672
Lys Ala Gly Val Thr Ile Thr Ala Tyr Ser Ser Phe Gly Pro Gln Ser
    210                 215                 220
 
ttc gtt gag atg aac caa ggt aga gct ttg aac acc cca acc ttg ttc   720
Phe Val Glu Met Asn Gln Gly Arg Ala Leu Asn Thr Pro Thr Leu Phe
225                 230                 235                 240
 
gca cac gac acc atc aag gct att gct gcc aag tac aac aag acc cca   768
Ala His Asp Thr Ile Lys Ala Ile Ala Ala Lys Tyr Asn Lys Thr Pro
                245                 250                 255
 
gct gag gtt tta ttg aga tgg gcc gcc caa aga ggt atc gct gtc att   816
Ala Glu Val Leu Leu Arg Trp Ala Ala Gln Arg Gly Ile Ala Val Ile
            260                 265                 270
 
cca gcc tct aac ctc cca gag aga tta gtc caa aac aga agt ttc aac   864
Pro Ala Ser Asn Leu Pro Glu Arg Leu Val Gln Asn Arg Ser Phe Asn
        275                 280                 285
 
acc ttc gac ttg acc aag gag gac ttc gag gaa atc gcc aag ttg gac   912
Thr Phe Asp Leu Thr Lys Glu Asp Phe Glu Glu Ile Ala Lys Leu Asp
    290                 295                 300
 
atc ggc ttg aga ttc aac gac cca tgg gac tgg gac aac att cca atc   960
Ile Gly Leu Arg Phe Asn Asp Pro Trp Asp Trp Asp Asn Ile Pro Ile
305                 310                 315                 320
 
ttc gtt taa                                                       969
Phe Val  *

 

<210> 266
<211> 322
<212> PRT
<213> C. tenuis

<400> 266
Met Ser Ala Ser Ile Pro Asp Ile Lys Leu Ser Ser Gly His Leu Met
 1               5                  10                  15      
Pro Ser Ile Gly Phe Gly Cys Trp Lys Leu Ala Asn Ala Thr Ala Gly
            20                  25                  30          
Glu Gln Val Tyr Gln Ala Ile Lys Ala Gly Tyr Arg Leu Phe Asp Gly
        35                  40                  45              
Ala Glu Asp Tyr Gly Asn Glu Lys Glu Val Gly Asp Gly Val Lys Arg
    50                  55                  60                  
Ala Ile Asp Glu Gly Leu Val Lys Arg Glu Glu Ile Phe Leu Thr Ser
65                  70                  75                  80  
Lys Leu Trp Asn Asn Tyr His Asp Pro Lys Asn Val Glu Thr Ala Leu
                85                  90                  95      
Asn Lys Thr Leu Ala Asp Leu Lys Val Asp Tyr Val Asp Leu Phe Leu
            100                 105                 110         
Ile His Phe Pro Ile Ala Phe Lys Phe Val Pro Ile Glu Glu Lys Tyr
        115                 120                 125             
Pro Pro Gly Phe Tyr Cys Gly Asp Gly Asn Asn Phe Val Tyr Glu Asp
    130                 135                 140                 
Val Pro Ile Leu Glu Thr Trp Lys Ala Leu Glu Lys Leu Val Ala Ala
145                 150                 155                 160 
Gly Lys Ile Lys Ser Ile Gly Val Ser Asn Phe Pro Gly Ala Leu Leu
                165                 170                 175     
Leu Asp Leu Leu Arg Gly Ala Thr Ile Lys Pro Ala Val Leu Gln Val
            180                 185                 190         
Glu His His Pro Tyr Leu Gln Gln Pro Lys Leu Ile Glu Phe Ala Gln
        195                 200                 205             
Lys Ala Gly Val Thr Ile Thr Ala Tyr Ser Ser Phe Gly Pro Gln Ser
    210                 215                 220                 
Phe Val Glu Met Asn Gln Gly Arg Ala Leu Asn Thr Pro Thr Leu Phe
225                 230                 235                 240 
Ala His Asp Thr Ile Lys Ala Ile Ala Ala Lys Tyr Asn Lys Thr Pro
                245                 250                 255     
Ala Glu Val Leu Leu Arg Trp Ala Ala Gln Arg Gly Ile Ala Val Ile
            260                 265                 270         
Pro Ala Ser Asn Leu Pro Glu Arg Leu Val Gln Asn Arg Ser Phe Asn
        275                 280                 285             
Thr Phe Asp Leu Thr Lys Glu Asp Phe Glu Glu Ile Ala Lys Leu Asp
    290                 295                 300                 
Ile Gly Leu Arg Phe Asn Asp Pro Trp Asp Trp Asp Asn Ile Pro Ile
305                 310                 315                 320 
Phe Val
        


<210> 267
<211> 966
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in S. cerevisiae

<220> 
<221> CDS            
<222> (1)...(966)

<400> 267
atg tct gct tct att cct gac att aaa ttg tct tct ggt cat tta atg   48
Met Ser Ala Ser Ile Pro Asp Ile Lys Leu Ser Ser Gly His Leu Met
 1               5                   10                  15
 
cca tct att ggt ttt gga tgt tgg aaa ttg gct aat gca act gct ggt   96
Pro Ser Ile Gly Phe Gly Cys Trp Lys Leu Ala Asn Ala Thr Ala Gly
             20                  25                  30
 
gaa caa gtt tat caa gct att aaa gca ggt tat aga ttg ttt gac ggt   144
Glu Gln Val Tyr Gln Ala Ile Lys Ala Gly Tyr Arg Leu Phe Asp Gly
         35                  40                  45
 
gct gaa gat tat ggt aat gaa aaa gaa gtt ggt gat ggt gtt aaa aga   192
Ala Glu Asp Tyr Gly Asn Glu Lys Glu Val Gly Asp Gly Val Lys Arg
     50                  55                  60
 
gct att gat gaa ggt ttg gta aaa aga gaa gaa ata ttt ttg act tct   240
Ala Ile Asp Glu Gly Leu Val Lys Arg Glu Glu Ile Phe Leu Thr Ser
 65                  70                  75                  80
 
aaa ttg tgg aat aat tat cat gat cct aaa aat gtt gaa act gct tta   288
Lys Leu Trp Asn Asn Tyr His Asp Pro Lys Asn Val Glu Thr Ala Leu
                 85                  90                  95
 
aat aaa aca ttg gct gat tta aaa gta gat tat gtt gat ttg ttt ttg   336
Asn Lys Thr Leu Ala Asp Leu Lys Val Asp Tyr Val Asp Leu Phe Leu
            100                 105                 110
 
att cat ttt cca ata gct ttt aaa ttc gtt cca att gaa gaa aaa tat   384
Ile His Phe Pro Ile Ala Phe Lys Phe Val Pro Ile Glu Glu Lys Tyr
        115                 120                 125
 
cct cct ggt ttt tat tgt ggt gat ggt aat aat ttt gta tat gaa gat   432
Pro Pro Gly Phe Tyr Cys Gly Asp Gly Asn Asn Phe Val Tyr Glu Asp
    130                 135                 140
 
gta cca att ttg gag act tgg aaa gct cta gaa aaa ttg gta gct gct   480
Val Pro Ile Leu Glu Thr Trp Lys Ala Leu Glu Lys Leu Val Ala Ala
145                 150                 155                 160
 
ggt aaa att aaa tct att ggt gtt tca aat ttt cca ggt gct ttg ttg   528
Gly Lys Ile Lys Ser Ile Gly Val Ser Asn Phe Pro Gly Ala Leu Leu
                165                 170                 175
 
ttg gat ttg tta aga ggt gca act att aaa ccc gct gtt cta caa gtt   576
Leu Asp Leu Leu Arg Gly Ala Thr Ile Lys Pro Ala Val Leu Gln Val
            180                 185                 190
 
gaa cat cat cca tat ttg caa caa cca aaa ttg att gaa ttt gct caa   624
Glu His His Pro Tyr Leu Gln Gln Pro Lys Leu Ile Glu Phe Ala Gln
        195                 200                 205
 
aaa gct ggt gtt act att act gct tat tct tct ttc ggt cca caa tct   672
Lys Ala Gly Val Thr Ile Thr Ala Tyr Ser Ser Phe Gly Pro Gln Ser
    210                 215                 220
 
ttt gta gaa atg aat caa ggt aga gct tta aat act cct aca tta ttt   720
Phe Val Glu Met Asn Gln Gly Arg Ala Leu Asn Thr Pro Thr Leu Phe
225                 230                 235                 240
 
gca cat gat act att aaa gct att gct gca aaa tat aat aag act cct   768
Ala His Asp Thr Ile Lys Ala Ile Ala Ala Lys Tyr Asn Lys Thr Pro
                245                 250                 255
 
gcc gaa gtt ttg ttg aga tgg gct gct caa aga ggc att gct gta att   816
Ala Glu Val Leu Leu Arg Trp Ala Ala Gln Arg Gly Ile Ala Val Ile
            260                 265                 270
 
cca aaa tct aat ttg cca gaa aga ttg gtt caa aat aga tct ttt aat   864
Pro Lys Ser Asn Leu Pro Glu Arg Leu Val Gln Asn Arg Ser Phe Asn
        275                 280                 285
 
act ttt gat ttg act aaa gaa gat ttt gaa gaa att gct aaa ttg gat   912
Thr Phe Asp Leu Thr Lys Glu Asp Phe Glu Glu Ile Ala Lys Leu Asp
    290                 295                 300
 
ata ggt ttg aga ttt aat gat cct tgg gac tgg gat aac att cca att   960
Ile Gly Leu Arg Phe Asn Asp Pro Trp Asp Trp Asp Asn Ile Pro Ile
305                 310                 315                 320
 
ttt gta                                                           966
Phe Val

 

<210> 268
<211> 322
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in S. cerevisiae

<400> 268
Met Ser Ala Ser Ile Pro Asp Ile Lys Leu Ser Ser Gly His Leu Met
 1               5                  10                  15      
Pro Ser Ile Gly Phe Gly Cys Trp Lys Leu Ala Asn Ala Thr Ala Gly
            20                  25                  30          
Glu Gln Val Tyr Gln Ala Ile Lys Ala Gly Tyr Arg Leu Phe Asp Gly
        35                  40                  45              
Ala Glu Asp Tyr Gly Asn Glu Lys Glu Val Gly Asp Gly Val Lys Arg
    50                  55                  60                  
Ala Ile Asp Glu Gly Leu Val Lys Arg Glu Glu Ile Phe Leu Thr Ser
65                  70                  75                  80  
Lys Leu Trp Asn Asn Tyr His Asp Pro Lys Asn Val Glu Thr Ala Leu
                85                  90                  95      
Asn Lys Thr Leu Ala Asp Leu Lys Val Asp Tyr Val Asp Leu Phe Leu
            100                 105                 110         
Ile His Phe Pro Ile Ala Phe Lys Phe Val Pro Ile Glu Glu Lys Tyr
        115                 120                 125             
Pro Pro Gly Phe Tyr Cys Gly Asp Gly Asn Asn Phe Val Tyr Glu Asp
    130                 135                 140                 
Val Pro Ile Leu Glu Thr Trp Lys Ala Leu Glu Lys Leu Val Ala Ala
145                 150                 155                 160 
Gly Lys Ile Lys Ser Ile Gly Val Ser Asn Phe Pro Gly Ala Leu Leu
                165                 170                 175     
Leu Asp Leu Leu Arg Gly Ala Thr Ile Lys Pro Ala Val Leu Gln Val
            180                 185                 190         
Glu His His Pro Tyr Leu Gln Gln Pro Lys Leu Ile Glu Phe Ala Gln
        195                 200                 205             
Lys Ala Gly Val Thr Ile Thr Ala Tyr Ser Ser Phe Gly Pro Gln Ser
    210                 215                 220                 
Phe Val Glu Met Asn Gln Gly Arg Ala Leu Asn Thr Pro Thr Leu Phe
225                 230                 235                 240 
Ala His Asp Thr Ile Lys Ala Ile Ala Ala Lys Tyr Asn Lys Thr Pro
                245                 250                 255     
Ala Glu Val Leu Leu Arg Trp Ala Ala Gln Arg Gly Ile Ala Val Ile
            260                 265                 270         
Pro Lys Ser Asn Leu Pro Glu Arg Leu Val Gln Asn Arg Ser Phe Asn
        275                 280                 285             
Thr Phe Asp Leu Thr Lys Glu Asp Phe Glu Glu Ile Ala Lys Leu Asp
    290                 295                 300                 
Ile Gly Leu Arg Phe Asn Asp Pro Trp Asp Trp Asp Asn Ile Pro Ile
305                 310                 315                 320 
Phe Val
        


<210> 269
<211> 988
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in S. cerevisiae

<220> 
<221> CDS            
<222> (12)...(977)

<400> 269
tactcaagct t atg tct gct tct att cct gac att aaa ttg tct tct ggt  50
             Met Ser Ala Ser Ile Pro Asp Ile Lys Leu Ser Ser Gly
              1               5                   10
 
cat tta atg cca tct att ggt ttt gga tgt tgg aaa ttg gct aat gca   98
His Leu Met Pro Ser Ile Gly Phe Gly Cys Trp Lys Leu Ala Asn Ala
     15                  20                  25
 
act gct ggt gaa caa gtt tat caa gct att aaa gca ggt tat aga ttg   146
Thr Ala Gly Glu Gln Val Tyr Gln Ala Ile Lys Ala Gly Tyr Arg Leu
 30                  35                  40                  45
 
ttt gac ggt gct gaa gat tat ggt aat gaa aaa gaa gtt ggt gat ggt   194
Phe Asp Gly Ala Glu Asp Tyr Gly Asn Glu Lys Glu Val Gly Asp Gly
                 50                  55                  60
 
gtt aaa aga gct att gat gaa ggt ttg gta aaa aga gaa gaa ata ttt   242
Val Lys Arg Ala Ile Asp Glu Gly Leu Val Lys Arg Glu Glu Ile Phe
             65                  70                  75
 
ttg act tct aaa ttg tgg aat aat tat cat gat cct aaa aat gtt gaa   290
Leu Thr Ser Lys Leu Trp Asn Asn Tyr His Asp Pro Lys Asn Val Glu
         80                  85                  90
 
act gct tta aat aaa aca ttg gct gat tta aaa gta gat tat gtt gat   338
Thr Ala Leu Asn Lys Thr Leu Ala Asp Leu Lys Val Asp Tyr Val Asp
     95                 100                 105
 
ttg ttt ttg att cat ttt cca ata gct ttt aaa ttc gtt cca att gaa   386
Leu Phe Leu Ile His Phe Pro Ile Ala Phe Lys Phe Val Pro Ile Glu
110                 115                 120                 125
 
gaa aaa tat cct cct ggt ttt tat tgt ggt gat ggt aat aat ttt gta   434
Glu Lys Tyr Pro Pro Gly Phe Tyr Cys Gly Asp Gly Asn Asn Phe Val
                130                 135                 140
 
tat gaa gat gta cca att ttg gag act tgg aaa gct cta gaa aaa ttg   482
Tyr Glu Asp Val Pro Ile Leu Glu Thr Trp Lys Ala Leu Glu Lys Leu
            145                 150                 155
 
gta gct gct ggt aaa att aaa tct att ggt gtt tca aat ttt cca ggt   530
Val Ala Ala Gly Lys Ile Lys Ser Ile Gly Val Ser Asn Phe Pro Gly
        160                 165                 170
 
gct ttg ttg ttg gat ttg tta aga ggt gca act att aaa ccc gct gtt   578
Ala Leu Leu Leu Asp Leu Leu Arg Gly Ala Thr Ile Lys Pro Ala Val
    175                 180                 185
 
cta caa gtt gaa cat cat cca tat ttg caa caa cca aaa ttg att gaa   626
Leu Gln Val Glu His His Pro Tyr Leu Gln Gln Pro Lys Leu Ile Glu
190                 195                 200                 205
 
ttt gct caa aaa gct ggt gtt act att act gct tat tct tct ttc ggt   674
Phe Ala Gln Lys Ala Gly Val Thr Ile Thr Ala Tyr Ser Ser Phe Gly
                210                 215                 220
 
cca caa tct ttt gta gaa atg aat caa ggt aga gct tta aat act cct   722
Pro Gln Ser Phe Val Glu Met Asn Gln Gly Arg Ala Leu Asn Thr Pro
            225                 230                 235
 
aca tta ttt gca cat gat act att aaa gct att gct gca aaa tat aat   770
Thr Leu Phe Ala His Asp Thr Ile Lys Ala Ile Ala Ala Lys Tyr Asn
        240                 245                 250
 
aag act cct gcc gaa gtt ttg ttg aga tgg gct gct caa aga ggc att   818
Lys Thr Pro Ala Glu Val Leu Leu Arg Trp Ala Ala Gln Arg Gly Ile
    255                 260                 265
 
gct gta att cca aaa tct aat ttg cca gaa aga ttg gtt caa aat aga   866
Ala Val Ile Pro Lys Ser Asn Leu Pro Glu Arg Leu Val Gln Asn Arg
270                 275                 280                 285
 
tct ttt aat act ttt gat ttg act aaa gaa gat ttt gaa gaa att gct   914
Ser Phe Asn Thr Phe Asp Leu Thr Lys Glu Asp Phe Glu Glu Ile Ala
                290                 295                 300
 
aaa ttg gat ata ggt ttg aga ttt aat gat cct tgg gac tgg gat aac   962
Lys Leu Asp Ile Gly Leu Arg Phe Asn Asp Pro Trp Asp Trp Asp Asn
            305                 310                 315
 
att cca att ttt gta gaattccgat g                                  988
Ile Pro Ile Phe Val
        320
 

<210> 270
<211> 322
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in S. cerevisiae

<400> 270
Met Ser Ala Ser Ile Pro Asp Ile Lys Leu Ser Ser Gly His Leu Met
 1               5                  10                  15      
Pro Ser Ile Gly Phe Gly Cys Trp Lys Leu Ala Asn Ala Thr Ala Gly
            20                  25                  30          
Glu Gln Val Tyr Gln Ala Ile Lys Ala Gly Tyr Arg Leu Phe Asp Gly
        35                  40                  45              
Ala Glu Asp Tyr Gly Asn Glu Lys Glu Val Gly Asp Gly Val Lys Arg
    50                  55                  60                  
Ala Ile Asp Glu Gly Leu Val Lys Arg Glu Glu Ile Phe Leu Thr Ser
65                  70                  75                  80  
Lys Leu Trp Asn Asn Tyr His Asp Pro Lys Asn Val Glu Thr Ala Leu
                85                  90                  95      
Asn Lys Thr Leu Ala Asp Leu Lys Val Asp Tyr Val Asp Leu Phe Leu
            100                 105                 110         
Ile His Phe Pro Ile Ala Phe Lys Phe Val Pro Ile Glu Glu Lys Tyr
        115                 120                 125             
Pro Pro Gly Phe Tyr Cys Gly Asp Gly Asn Asn Phe Val Tyr Glu Asp
    130                 135                 140                 
Val Pro Ile Leu Glu Thr Trp Lys Ala Leu Glu Lys Leu Val Ala Ala
145                 150                 155                 160 
Gly Lys Ile Lys Ser Ile Gly Val Ser Asn Phe Pro Gly Ala Leu Leu
                165                 170                 175     
Leu Asp Leu Leu Arg Gly Ala Thr Ile Lys Pro Ala Val Leu Gln Val
            180                 185                 190         
Glu His His Pro Tyr Leu Gln Gln Pro Lys Leu Ile Glu Phe Ala Gln
        195                 200                 205             
Lys Ala Gly Val Thr Ile Thr Ala Tyr Ser Ser Phe Gly Pro Gln Ser
    210                 215                 220                 
Phe Val Glu Met Asn Gln Gly Arg Ala Leu Asn Thr Pro Thr Leu Phe
225                 230                 235                 240 
Ala His Asp Thr Ile Lys Ala Ile Ala Ala Lys Tyr Asn Lys Thr Pro
                245                 250                 255     
Ala Glu Val Leu Leu Arg Trp Ala Ala Gln Arg Gly Ile Ala Val Ile
            260                 265                 270         
Pro Lys Ser Asn Leu Pro Glu Arg Leu Val Gln Asn Arg Ser Phe Asn
        275                 280                 285             
Thr Phe Asp Leu Thr Lys Glu Asp Phe Glu Glu Ile Ala Lys Leu Asp
    290                 295                 300                 
Ile Gly Leu Arg Phe Asn Asp Pro Trp Asp Trp Asp Asn Ile Pro Ile
305                 310                 315                 320 
Phe Val
        


<210> 271
<211> 994
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in S. cerevisiae

<220> 
<221> CDS            
<222> (15)...(980)

<400> 271
gaatactcca tatg atg tct gct tct att cct gac att aaa ttg tct tct   50
                Met Ser Ala Ser Ile Pro Asp Ile Lys Leu Ser Ser
                 1               5                   10
 
ggt cat tta atg cca tct att ggt ttt gga tgt tgg aaa ttg gct aat   98
Gly His Leu Met Pro Ser Ile Gly Phe Gly Cys Trp Lys Leu Ala Asn
         15                  20                  25
 
gca act gct ggt gaa caa gtt tat caa gct att aaa gca ggt tat aga   146
Ala Thr Ala Gly Glu Gln Val Tyr Gln Ala Ile Lys Ala Gly Tyr Arg
     30                  35                  40
 
ttg ttt gac ggt gct gaa gat tat ggt aat gaa aaa gaa gtt ggt gat   194
Leu Phe Asp Gly Ala Glu Asp Tyr Gly Asn Glu Lys Glu Val Gly Asp
 45                  50                  55                  60
 
ggt gtt aaa aga gct att gat gaa ggt ttg gta aaa aga gaa gaa ata   242
Gly Val Lys Arg Ala Ile Asp Glu Gly Leu Val Lys Arg Glu Glu Ile
                 65                  70                  75
 
ttt ttg act tct aaa ttg tgg aat aat tat cat gat cct aaa aat gtt   290
Phe Leu Thr Ser Lys Leu Trp Asn Asn Tyr His Asp Pro Lys Asn Val
             80                  85                  90
 
gaa act gct tta aat aaa aca ttg gct gat tta aaa gta gat tat gtt   338
Glu Thr Ala Leu Asn Lys Thr Leu Ala Asp Leu Lys Val Asp Tyr Val
         95                 100                 105
 
gat ttg ttt ttg att cat ttt cca ata gct ttt aaa ttc gtt cca att   386
Asp Leu Phe Leu Ile His Phe Pro Ile Ala Phe Lys Phe Val Pro Ile
    110                 115                 120
 
gaa gaa aaa tat cct cct ggt ttt tat tgt ggt gat ggt aat aat ttt   434
Glu Glu Lys Tyr Pro Pro Gly Phe Tyr Cys Gly Asp Gly Asn Asn Phe
125                 130                 135                 140
 
gta tat gaa gat gta cca att ttg gag act tgg aaa gct cta gaa aaa   482
Val Tyr Glu Asp Val Pro Ile Leu Glu Thr Trp Lys Ala Leu Glu Lys
                145                 150                 155
 
ttg gta gct gct ggt aaa att aaa tct att ggt gtt tca aat ttt cca   530
Leu Val Ala Ala Gly Lys Ile Lys Ser Ile Gly Val Ser Asn Phe Pro
            160                 165                 170
 
ggt gct ttg ttg ttg gat ttg tta aga ggt gca act att aaa ccc gct   578
Gly Ala Leu Leu Leu Asp Leu Leu Arg Gly Ala Thr Ile Lys Pro Ala
        175                 180                 185
 
gtt cta caa gtt gaa cat cat cca tat ttg caa caa cca aaa ttg att   626
Val Leu Gln Val Glu His His Pro Tyr Leu Gln Gln Pro Lys Leu Ile
    190                 195                 200
 
gaa ttt gct caa aaa gct ggt gtt act att act gct tat tct tct ttc   674
Glu Phe Ala Gln Lys Ala Gly Val Thr Ile Thr Ala Tyr Ser Ser Phe
205                 210                 215                 220
 
ggt cca caa tct ttt gta gaa atg aat caa ggt aga gct tta aat act   722
Gly Pro Gln Ser Phe Val Glu Met Asn Gln Gly Arg Ala Leu Asn Thr
                225                 230                 235
 
cct aca tta ttt gca cat gat act att aaa gct att gct gca aaa tat   770
Pro Thr Leu Phe Ala His Asp Thr Ile Lys Ala Ile Ala Ala Lys Tyr
            240                 245                 250
 
aat aag act cct gcc gaa gtt ttg ttg aga tgg gct gct caa aga ggc   818
Asn Lys Thr Pro Ala Glu Val Leu Leu Arg Trp Ala Ala Gln Arg Gly
        255                 260                 265
 
att gct gta att cca aaa tct aat ttg cca gaa aga ttg gtt caa aat   866
Ile Ala Val Ile Pro Lys Ser Asn Leu Pro Glu Arg Leu Val Gln Asn
    270                 275                 280
 
aga tct ttt aat act ttt gat ttg act aaa gaa gat ttt gaa gaa att   914
Arg Ser Phe Asn Thr Phe Asp Leu Thr Lys Glu Asp Phe Glu Glu Ile
285                 290                 295                 300
 
gct aaa ttg gat ata ggt ttg aga ttt aat gat cct tgg gac tgg gat   962
Ala Lys Leu Asp Ile Gly Leu Arg Phe Asn Asp Pro Trp Asp Trp Asp
                305                 310                 315
 
aac att cca att ttt gta actagtcagt gcct                           994
Asn Ile Pro Ile Phe Val
            320
 

<210> 272
<211> 322
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in S. cerevisiae

<400> 272
Met Ser Ala Ser Ile Pro Asp Ile Lys Leu Ser Ser Gly His Leu Met
 1               5                  10                  15      
Pro Ser Ile Gly Phe Gly Cys Trp Lys Leu Ala Asn Ala Thr Ala Gly
            20                  25                  30          
Glu Gln Val Tyr Gln Ala Ile Lys Ala Gly Tyr Arg Leu Phe Asp Gly
        35                  40                  45              
Ala Glu Asp Tyr Gly Asn Glu Lys Glu Val Gly Asp Gly Val Lys Arg
    50                  55                  60                  
Ala Ile Asp Glu Gly Leu Val Lys Arg Glu Glu Ile Phe Leu Thr Ser
65                  70                  75                  80  
Lys Leu Trp Asn Asn Tyr His Asp Pro Lys Asn Val Glu Thr Ala Leu
                85                  90                  95      
Asn Lys Thr Leu Ala Asp Leu Lys Val Asp Tyr Val Asp Leu Phe Leu
            100                 105                 110         
Ile His Phe Pro Ile Ala Phe Lys Phe Val Pro Ile Glu Glu Lys Tyr
        115                 120                 125             
Pro Pro Gly Phe Tyr Cys Gly Asp Gly Asn Asn Phe Val Tyr Glu Asp
    130                 135                 140                 
Val Pro Ile Leu Glu Thr Trp Lys Ala Leu Glu Lys Leu Val Ala Ala
145                 150                 155                 160 
Gly Lys Ile Lys Ser Ile Gly Val Ser Asn Phe Pro Gly Ala Leu Leu
                165                 170                 175     
Leu Asp Leu Leu Arg Gly Ala Thr Ile Lys Pro Ala Val Leu Gln Val
            180                 185                 190         
Glu His His Pro Tyr Leu Gln Gln Pro Lys Leu Ile Glu Phe Ala Gln
        195                 200                 205             
Lys Ala Gly Val Thr Ile Thr Ala Tyr Ser Ser Phe Gly Pro Gln Ser
    210                 215                 220                 
Phe Val Glu Met Asn Gln Gly Arg Ala Leu Asn Thr Pro Thr Leu Phe
225                 230                 235                 240 
Ala His Asp Thr Ile Lys Ala Ile Ala Ala Lys Tyr Asn Lys Thr Pro
                245                 250                 255     
Ala Glu Val Leu Leu Arg Trp Ala Ala Gln Arg Gly Ile Ala Val Ile
            260                 265                 270         
Pro Lys Ser Asn Leu Pro Glu Arg Leu Val Gln Asn Arg Ser Phe Asn
        275                 280                 285             
Thr Phe Asp Leu Thr Lys Glu Asp Phe Glu Glu Ile Ala Lys Leu Asp
    290                 295                 300                 
Ile Gly Leu Arg Phe Asn Asp Pro Trp Asp Trp Asp Asn Ile Pro Ile
305                 310                 315                 320 
Phe Val
        


<210> 273
<211> 966
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in E. coli

<220> 
<221> CDS            
<222> (1)...(966)

<400> 273
atg tct gcg tct atc ccg gac atc aaa ctg tct tct ggt cac ctg atg   48
Met Ser Ala Ser Ile Pro Asp Ile Lys Leu Ser Ser Gly His Leu Met
 1               5                   10                  15
 
ccg tct atc ggt ttc ggt tgc tgg aaa ctg gct aat gcg act gcg ggt   96
Pro Ser Ile Gly Phe Gly Cys Trp Lys Leu Ala Asn Ala Thr Ala Gly
             20                  25                  30
 
gaa cag gtt tac caa gcg atc aag gcg ggt tat cgt ctg ttc gat ggt   144
Glu Gln Val Tyr Gln Ala Ile Lys Ala Gly Tyr Arg Leu Phe Asp Gly
         35                  40                  45
 
gcg gaa gac tac ggt aac gaa aaa gaa gtt ggt gac ggt gtt aaa cgt   192
Ala Glu Asp Tyr Gly Asn Glu Lys Glu Val Gly Asp Gly Val Lys Arg
     50                  55                  60
 
gcg att gac gaa ggt ctg gtt aaa cgt gaa gaa atc ttc ctg acc tct   240
Ala Ile Asp Glu Gly Leu Val Lys Arg Glu Glu Ile Phe Leu Thr Ser
 65                  70                  75                  80
 
aaa ctg tgg aac aac tac cac gac ccg aaa aac gtt gaa acc gcg ttg   288
Lys Leu Trp Asn Asn Tyr His Asp Pro Lys Asn Val Glu Thr Ala Leu
                 85                  90                  95
 
aac aaa acc ctg gct gat ctg aaa gtt gac tac gtt gac ctg ttc ctg   336
Asn Lys Thr Leu Ala Asp Leu Lys Val Asp Tyr Val Asp Leu Phe Leu
            100                 105                 110
 
atc cac ttc cca atc gcg ttc aaa ttt gtt ccg atc gaa gaa aaa tac   384
Ile His Phe Pro Ile Ala Phe Lys Phe Val Pro Ile Glu Glu Lys Tyr
        115                 120                 125
 
cca cca ggt ttc tac tgc ggt gac ggt aac aac ttt gtt tac gaa gac   432
Pro Pro Gly Phe Tyr Cys Gly Asp Gly Asn Asn Phe Val Tyr Glu Asp
    130                 135                 140
 
gtt ccg atc ttg gaa act tgg aag gcg ctc gaa aaa ctg gtt gcg gcg   480
Val Pro Ile Leu Glu Thr Trp Lys Ala Leu Glu Lys Leu Val Ala Ala
145                 150                 155                 160
 
ggt aaa atc aaa tct atc ggt gtt tcg aat ttc cca ggt gct ctg ctg   528
Gly Lys Ile Lys Ser Ile Gly Val Ser Asn Phe Pro Gly Ala Leu Leu
                165                 170                 175
 
ctg gac ctg ctg cgt ggt gcg acc atc aaa cca gct gtt ctc cag gtt   576
Leu Asp Leu Leu Arg Gly Ala Thr Ile Lys Pro Ala Val Leu Gln Val
            180                 185                 190
 
gaa cac cac ccg tac ctc caa cag ccg aaa ctg atc gaa ttt gcg cag   624
Glu His His Pro Tyr Leu Gln Gln Pro Lys Leu Ile Glu Phe Ala Gln
        195                 200                 205
 
aaa gct ggt gtt acc atc acc gcg tat tct tct ttc ggt cca cag tct   672
Lys Ala Gly Val Thr Ile Thr Ala Tyr Ser Ser Phe Gly Pro Gln Ser
    210                 215                 220
 
ttc gtt gaa atg aat cag ggt cgt gct ctg aac acc ccg acc ttg ttc   720
Phe Val Glu Met Asn Gln Gly Arg Ala Leu Asn Thr Pro Thr Leu Phe
225                 230                 235                 240
 
gcg cac gac acc atc aaa gct att gcg gcg aaa tac aac aaa acc ccg   768
Ala His Asp Thr Ile Lys Ala Ile Ala Ala Lys Tyr Asn Lys Thr Pro
                245                 250                 255
 
gcg gaa gtt ctg ctg cgt tgg gct gct cag cgt ggt atc gcg gtt atc   816
Ala Glu Val Leu Leu Arg Trp Ala Ala Gln Arg Gly Ile Ala Val Ile
            260                 265                 270
 
ccg aaa tct aac ctg ccg gaa cgt ctg gtt cag aac cgt tct ttc aac   864
Pro Lys Ser Asn Leu Pro Glu Arg Leu Val Gln Asn Arg Ser Phe Asn
        275                 280                 285
 
acc ttc gac ctg acc aaa gaa gac ttc gaa gaa atc gcg aaa ctg gac   912
Thr Phe Asp Leu Thr Lys Glu Asp Phe Glu Glu Ile Ala Lys Leu Asp
    290                 295                 300
 
atc ggt ctg cgt ttc aac gac ccg tgg gat tgg gac aac att ccg atc   960
Ile Gly Leu Arg Phe Asn Asp Pro Trp Asp Trp Asp Asn Ile Pro Ile
305                 310                 315                 320
 
ttc gtt                                                           966
Phe Val

 

<210> 274
<211> 322
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in E. coli

<400> 274
Met Ser Ala Ser Ile Pro Asp Ile Lys Leu Ser Ser Gly His Leu Met
 1               5                  10                  15      
Pro Ser Ile Gly Phe Gly Cys Trp Lys Leu Ala Asn Ala Thr Ala Gly
            20                  25                  30          
Glu Gln Val Tyr Gln Ala Ile Lys Ala Gly Tyr Arg Leu Phe Asp Gly
        35                  40                  45              
Ala Glu Asp Tyr Gly Asn Glu Lys Glu Val Gly Asp Gly Val Lys Arg
    50                  55                  60                  
Ala Ile Asp Glu Gly Leu Val Lys Arg Glu Glu Ile Phe Leu Thr Ser
65                  70                  75                  80  
Lys Leu Trp Asn Asn Tyr His Asp Pro Lys Asn Val Glu Thr Ala Leu
                85                  90                  95      
Asn Lys Thr Leu Ala Asp Leu Lys Val Asp Tyr Val Asp Leu Phe Leu
            100                 105                 110         
Ile His Phe Pro Ile Ala Phe Lys Phe Val Pro Ile Glu Glu Lys Tyr
        115                 120                 125             
Pro Pro Gly Phe Tyr Cys Gly Asp Gly Asn Asn Phe Val Tyr Glu Asp
    130                 135                 140                 
Val Pro Ile Leu Glu Thr Trp Lys Ala Leu Glu Lys Leu Val Ala Ala
145                 150                 155                 160 
Gly Lys Ile Lys Ser Ile Gly Val Ser Asn Phe Pro Gly Ala Leu Leu
                165                 170                 175     
Leu Asp Leu Leu Arg Gly Ala Thr Ile Lys Pro Ala Val Leu Gln Val
            180                 185                 190         
Glu His His Pro Tyr Leu Gln Gln Pro Lys Leu Ile Glu Phe Ala Gln
        195                 200                 205             
Lys Ala Gly Val Thr Ile Thr Ala Tyr Ser Ser Phe Gly Pro Gln Ser
    210                 215                 220                 
Phe Val Glu Met Asn Gln Gly Arg Ala Leu Asn Thr Pro Thr Leu Phe
225                 230                 235                 240 
Ala His Asp Thr Ile Lys Ala Ile Ala Ala Lys Tyr Asn Lys Thr Pro
                245                 250                 255     
Ala Glu Val Leu Leu Arg Trp Ala Ala Gln Arg Gly Ile Ala Val Ile
            260                 265                 270         
Pro Lys Ser Asn Leu Pro Glu Arg Leu Val Gln Asn Arg Ser Phe Asn
        275                 280                 285             
Thr Phe Asp Leu Thr Lys Glu Asp Phe Glu Glu Ile Ala Lys Leu Asp
    290                 295                 300                 
Ile Gly Leu Arg Phe Asn Asp Pro Trp Asp Trp Asp Asn Ile Pro Ile
305                 310                 315                 320 
Phe Val
        


<210> 275
<211> 994
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in E. coli

<220> 
<221> CDS            
<222> (15)...(980)

<400> 275
gaatactcca tatg atg tct gcg tct atc ccg gac atc aaa ctg tct tct   50
                Met Ser Ala Ser Ile Pro Asp Ile Lys Leu Ser Ser
                 1               5                   10
 
ggt cac ctg atg ccg tct atc ggt ttc ggt tgc tgg aaa ctg gct aat   98
Gly His Leu Met Pro Ser Ile Gly Phe Gly Cys Trp Lys Leu Ala Asn
         15                  20                  25
 
gcg act gcg ggt gaa cag gtt tac caa gcg atc aag gcg ggt tat cgt   146
Ala Thr Ala Gly Glu Gln Val Tyr Gln Ala Ile Lys Ala Gly Tyr Arg
     30                  35                  40
 
ctg ttc gat ggt gcg gaa gac tac ggt aac gaa aaa gaa gtt ggt gac   194
Leu Phe Asp Gly Ala Glu Asp Tyr Gly Asn Glu Lys Glu Val Gly Asp
 45                  50                  55                  60
 
ggt gtt aaa cgt gcg att gac gaa ggt ctg gtt aaa cgt gaa gaa atc   242
Gly Val Lys Arg Ala Ile Asp Glu Gly Leu Val Lys Arg Glu Glu Ile
                 65                  70                  75
 
ttc ctg acc tct aaa ctg tgg aac aac tac cac gac ccg aaa aac gtt   290
Phe Leu Thr Ser Lys Leu Trp Asn Asn Tyr His Asp Pro Lys Asn Val
             80                  85                  90
 
gaa acc gcg ttg aac aaa acc ctg gct gat ctg aaa gtt gac tac gtt   338
Glu Thr Ala Leu Asn Lys Thr Leu Ala Asp Leu Lys Val Asp Tyr Val
         95                 100                 105
 
gac ctg ttc ctg atc cac ttc cca atc gcg ttc aaa ttt gtt ccg atc   386
Asp Leu Phe Leu Ile His Phe Pro Ile Ala Phe Lys Phe Val Pro Ile
    110                 115                 120
 
gaa gaa aaa tac cca cca ggt ttc tac tgc ggt gac ggt aac aac ttt   434
Glu Glu Lys Tyr Pro Pro Gly Phe Tyr Cys Gly Asp Gly Asn Asn Phe
125                 130                 135                 140
 
gtt tac gaa gac gtt ccg atc ttg gaa act tgg aag gcg ctc gaa aaa   482
Val Tyr Glu Asp Val Pro Ile Leu Glu Thr Trp Lys Ala Leu Glu Lys
                145                 150                 155
 
ctg gtt gcg gcg ggt aaa atc aaa tct atc ggt gtt tcg aat ttc cca   530
Leu Val Ala Ala Gly Lys Ile Lys Ser Ile Gly Val Ser Asn Phe Pro
            160                 165                 170
 
ggt gct ctg ctg ctg gac ctg ctg cgt ggt gcg acc atc aaa cca gct   578
Gly Ala Leu Leu Leu Asp Leu Leu Arg Gly Ala Thr Ile Lys Pro Ala
        175                 180                 185
 
gtt ctc cag gtt gaa cac cac ccg tac ctc caa cag ccg aaa ctg atc   626
Val Leu Gln Val Glu His His Pro Tyr Leu Gln Gln Pro Lys Leu Ile
    190                 195                 200
 
gaa ttt gcg cag aaa gct ggt gtt acc atc acc gcg tat tct tct ttc   674
Glu Phe Ala Gln Lys Ala Gly Val Thr Ile Thr Ala Tyr Ser Ser Phe
205                 210                 215                 220
 
ggt cca cag tct ttc gtt gaa atg aat cag ggt cgt gct ctg aac acc   722
Gly Pro Gln Ser Phe Val Glu Met Asn Gln Gly Arg Ala Leu Asn Thr
                225                 230                 235
 
ccg acc ttg ttc gcg cac gac acc atc aaa gct att gcg gcg aaa tac   770
Pro Thr Leu Phe Ala His Asp Thr Ile Lys Ala Ile Ala Ala Lys Tyr
            240                 245                 250
 
aac aaa acc ccg gcg gaa gtt ctg ctg cgt tgg gct gct cag cgt ggt   818
Asn Lys Thr Pro Ala Glu Val Leu Leu Arg Trp Ala Ala Gln Arg Gly
        255                 260                 265
 
atc gcg gtt atc ccg aaa tct aac ctg ccg gaa cgt ctg gtt cag aac   866
Ile Ala Val Ile Pro Lys Ser Asn Leu Pro Glu Arg Leu Val Gln Asn
    270                 275                 280
 
cgt tct ttc aac acc ttc gac ctg acc aaa gaa gac ttc gaa gaa atc   914
Arg Ser Phe Asn Thr Phe Asp Leu Thr Lys Glu Asp Phe Glu Glu Ile
285                 290                 295                 300
 
gcg aaa ctg gac atc ggt ctg cgt ttc aac gac ccg tgg gat tgg gac   962
Ala Lys Leu Asp Ile Gly Leu Arg Phe Asn Asp Pro Trp Asp Trp Asp
                305                 310                 315
 
aac att ccg atc ttc gtt actagtcagt gcct                           994
Asn Ile Pro Ile Phe Val
            320
 

<210> 276
<211> 322
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in E. coli

<400> 276
Met Ser Ala Ser Ile Pro Asp Ile Lys Leu Ser Ser Gly His Leu Met
 1               5                  10                  15      
Pro Ser Ile Gly Phe Gly Cys Trp Lys Leu Ala Asn Ala Thr Ala Gly
            20                  25                  30          
Glu Gln Val Tyr Gln Ala Ile Lys Ala Gly Tyr Arg Leu Phe Asp Gly
        35                  40                  45              
Ala Glu Asp Tyr Gly Asn Glu Lys Glu Val Gly Asp Gly Val Lys Arg
    50                  55                  60                  
Ala Ile Asp Glu Gly Leu Val Lys Arg Glu Glu Ile Phe Leu Thr Ser
65                  70                  75                  80  
Lys Leu Trp Asn Asn Tyr His Asp Pro Lys Asn Val Glu Thr Ala Leu
                85                  90                  95      
Asn Lys Thr Leu Ala Asp Leu Lys Val Asp Tyr Val Asp Leu Phe Leu
            100                 105                 110         
Ile His Phe Pro Ile Ala Phe Lys Phe Val Pro Ile Glu Glu Lys Tyr
        115                 120                 125             
Pro Pro Gly Phe Tyr Cys Gly Asp Gly Asn Asn Phe Val Tyr Glu Asp
    130                 135                 140                 
Val Pro Ile Leu Glu Thr Trp Lys Ala Leu Glu Lys Leu Val Ala Ala
145                 150                 155                 160 
Gly Lys Ile Lys Ser Ile Gly Val Ser Asn Phe Pro Gly Ala Leu Leu
                165                 170                 175     
Leu Asp Leu Leu Arg Gly Ala Thr Ile Lys Pro Ala Val Leu Gln Val
            180                 185                 190         
Glu His His Pro Tyr Leu Gln Gln Pro Lys Leu Ile Glu Phe Ala Gln
        195                 200                 205             
Lys Ala Gly Val Thr Ile Thr Ala Tyr Ser Ser Phe Gly Pro Gln Ser
    210                 215                 220                 
Phe Val Glu Met Asn Gln Gly Arg Ala Leu Asn Thr Pro Thr Leu Phe
225                 230                 235                 240 
Ala His Asp Thr Ile Lys Ala Ile Ala Ala Lys Tyr Asn Lys Thr Pro
                245                 250                 255     
Ala Glu Val Leu Leu Arg Trp Ala Ala Gln Arg Gly Ile Ala Val Ile
            260                 265                 270         
Pro Lys Ser Asn Leu Pro Glu Arg Leu Val Gln Asn Arg Ser Phe Asn
        275                 280                 285             
Thr Phe Asp Leu Thr Lys Glu Asp Phe Glu Glu Ile Ala Lys Leu Asp
    290                 295                 300                 
Ile Gly Leu Arg Phe Asn Asp Pro Trp Asp Trp Asp Asn Ile Pro Ile
305                 310                 315                 320 
Phe Val
        


<210> 277
<211> 988
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in E. coli

<220> 
<221> CDS            
<222> (12)...(977)

<400> 277
tactcaagct t atg tct gcg tct atc ccg gac atc aaa ctg tct tct ggt  50
             Met Ser Ala Ser Ile Pro Asp Ile Lys Leu Ser Ser Gly
              1               5                   10
 
cac ctg atg ccg tct atc ggt ttc ggt tgc tgg aaa ctg gct aat gcg   98
His Leu Met Pro Ser Ile Gly Phe Gly Cys Trp Lys Leu Ala Asn Ala
     15                  20                  25
 
act gcg ggt gaa cag gtt tac caa gcg atc aag gcg ggt tat cgt ctg   146
Thr Ala Gly Glu Gln Val Tyr Gln Ala Ile Lys Ala Gly Tyr Arg Leu
 30                  35                  40                  45
 
ttc gat ggt gcg gaa gac tac ggt aac gaa aaa gaa gtt ggt gac ggt   194
Phe Asp Gly Ala Glu Asp Tyr Gly Asn Glu Lys Glu Val Gly Asp Gly
                 50                  55                  60
 
gtt aaa cgt gcg att gac gaa ggt ctg gtt aaa cgt gaa gaa atc ttc   242
Val Lys Arg Ala Ile Asp Glu Gly Leu Val Lys Arg Glu Glu Ile Phe
             65                  70                  75
 
ctg acc tct aaa ctg tgg aac aac tac cac gac ccg aaa aac gtt gaa   290
Leu Thr Ser Lys Leu Trp Asn Asn Tyr His Asp Pro Lys Asn Val Glu
         80                  85                  90
 
acc gcg ttg aac aaa acc ctg gct gat ctg aaa gtt gac tac gtt gac   338
Thr Ala Leu Asn Lys Thr Leu Ala Asp Leu Lys Val Asp Tyr Val Asp
     95                 100                 105
 
ctg ttc ctg atc cac ttc cca atc gcg ttc aaa ttt gtt ccg atc gaa   386
Leu Phe Leu Ile His Phe Pro Ile Ala Phe Lys Phe Val Pro Ile Glu
110                 115                 120                 125
 
gaa aaa tac cca cca ggt ttc tac tgc ggt gac ggt aac aac ttt gtt   434
Glu Lys Tyr Pro Pro Gly Phe Tyr Cys Gly Asp Gly Asn Asn Phe Val
                130                 135                 140
 
tac gaa gac gtt ccg atc ttg gaa act tgg aag gcg ctc gaa aaa ctg   482
Tyr Glu Asp Val Pro Ile Leu Glu Thr Trp Lys Ala Leu Glu Lys Leu
            145                 150                 155
 
gtt gcg gcg ggt aaa atc aaa tct atc ggt gtt tcg aat ttc cca ggt   530
Val Ala Ala Gly Lys Ile Lys Ser Ile Gly Val Ser Asn Phe Pro Gly
        160                 165                 170
 
gct ctg ctg ctg gac ctg ctg cgt ggt gcg acc atc aaa cca gct gtt   578
Ala Leu Leu Leu Asp Leu Leu Arg Gly Ala Thr Ile Lys Pro Ala Val
    175                 180                 185
 
ctc cag gtt gaa cac cac ccg tac ctc caa cag ccg aaa ctg atc gaa   626
Leu Gln Val Glu His His Pro Tyr Leu Gln Gln Pro Lys Leu Ile Glu
190                 195                 200                 205
 
ttt gcg cag aaa gct ggt gtt acc atc acc gcg tat tct tct ttc ggt   674
Phe Ala Gln Lys Ala Gly Val Thr Ile Thr Ala Tyr Ser Ser Phe Gly
                210                 215                 220
 
cca cag tct ttc gtt gaa atg aat cag ggt cgt gct ctg aac acc ccg   722
Pro Gln Ser Phe Val Glu Met Asn Gln Gly Arg Ala Leu Asn Thr Pro
            225                 230                 235
 
acc ttg ttc gcg cac gac acc atc aaa gct att gcg gcg aaa tac aac   770
Thr Leu Phe Ala His Asp Thr Ile Lys Ala Ile Ala Ala Lys Tyr Asn
        240                 245                 250
 
aaa acc ccg gcg gaa gtt ctg ctg cgt tgg gct gct cag cgt ggt atc   818
Lys Thr Pro Ala Glu Val Leu Leu Arg Trp Ala Ala Gln Arg Gly Ile
    255                 260                 265
 
gcg gtt atc ccg aaa tct aac ctg ccg gaa cgt ctg gtt cag aac cgt   866
Ala Val Ile Pro Lys Ser Asn Leu Pro Glu Arg Leu Val Gln Asn Arg
270                 275                 280                 285
 
tct ttc aac acc ttc gac ctg acc aaa gaa gac ttc gaa gaa atc gcg   914
Ser Phe Asn Thr Phe Asp Leu Thr Lys Glu Asp Phe Glu Glu Ile Ala
                290                 295                 300
 
aaa ctg gac atc ggt ctg cgt ttc aac gac ccg tgg gat tgg gac aac   962
Lys Leu Asp Ile Gly Leu Arg Phe Asn Asp Pro Trp Asp Trp Asp Asn
            305                 310                 315
 
att ccg atc ttc gtt gaattccgat g                                  988
Ile Pro Ile Phe Val
        320
 

<210> 278
<211> 322
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in E. coli

<400> 278
Met Ser Ala Ser Ile Pro Asp Ile Lys Leu Ser Ser Gly His Leu Met
 1               5                  10                  15      
Pro Ser Ile Gly Phe Gly Cys Trp Lys Leu Ala Asn Ala Thr Ala Gly
            20                  25                  30          
Glu Gln Val Tyr Gln Ala Ile Lys Ala Gly Tyr Arg Leu Phe Asp Gly
        35                  40                  45              
Ala Glu Asp Tyr Gly Asn Glu Lys Glu Val Gly Asp Gly Val Lys Arg
    50                  55                  60                  
Ala Ile Asp Glu Gly Leu Val Lys Arg Glu Glu Ile Phe Leu Thr Ser
65                  70                  75                  80  
Lys Leu Trp Asn Asn Tyr His Asp Pro Lys Asn Val Glu Thr Ala Leu
                85                  90                  95      
Asn Lys Thr Leu Ala Asp Leu Lys Val Asp Tyr Val Asp Leu Phe Leu
            100                 105                 110         
Ile His Phe Pro Ile Ala Phe Lys Phe Val Pro Ile Glu Glu Lys Tyr
        115                 120                 125             
Pro Pro Gly Phe Tyr Cys Gly Asp Gly Asn Asn Phe Val Tyr Glu Asp
    130                 135                 140                 
Val Pro Ile Leu Glu Thr Trp Lys Ala Leu Glu Lys Leu Val Ala Ala
145                 150                 155                 160 
Gly Lys Ile Lys Ser Ile Gly Val Ser Asn Phe Pro Gly Ala Leu Leu
                165                 170                 175     
Leu Asp Leu Leu Arg Gly Ala Thr Ile Lys Pro Ala Val Leu Gln Val
            180                 185                 190         
Glu His His Pro Tyr Leu Gln Gln Pro Lys Leu Ile Glu Phe Ala Gln
        195                 200                 205             
Lys Ala Gly Val Thr Ile Thr Ala Tyr Ser Ser Phe Gly Pro Gln Ser
    210                 215                 220                 
Phe Val Glu Met Asn Gln Gly Arg Ala Leu Asn Thr Pro Thr Leu Phe
225                 230                 235                 240 
Ala His Asp Thr Ile Lys Ala Ile Ala Ala Lys Tyr Asn Lys Thr Pro
                245                 250                 255     
Ala Glu Val Leu Leu Arg Trp Ala Ala Gln Arg Gly Ile Ala Val Ile
            260                 265                 270         
Pro Lys Ser Asn Leu Pro Glu Arg Leu Val Gln Asn Arg Ser Phe Asn
        275                 280                 285             
Thr Phe Asp Leu Thr Lys Glu Asp Phe Glu Glu Ile Ala Lys Leu Asp
    290                 295                 300                 
Ile Gly Leu Arg Phe Asn Asp Pro Trp Asp Trp Asp Asn Ile Pro Ile
305                 310                 315                 320 
Phe Val
        


<210> 279
<211> 966
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in P. pastoris

<220> 
<221> CDS            
<222> (1)...(966)

<400> 279
atg tct gct tct att cct gac att aaa tta tct tct gga cat ttg atg   48
Met Ser Ala Ser Ile Pro Asp Ile Lys Leu Ser Ser Gly His Leu Met
 1               5                   10                  15
 
cca tct att gga ttt ggt tgt tgg aaa ttg gct aat gca act gct gga   96
Pro Ser Ile Gly Phe Gly Cys Trp Lys Leu Ala Asn Ala Thr Ala Gly
             20                  25                  30
 
gaa caa gtt tat cag gct att aaa gct gga tat aga ttg ttt gat gga   144
Glu Gln Val Tyr Gln Ala Ile Lys Ala Gly Tyr Arg Leu Phe Asp Gly
         35                  40                  45
 
gct gaa gat tat gga aat gaa aaa gaa gtt gga gac ggt gtt aaa aga   192
Ala Glu Asp Tyr Gly Asn Glu Lys Glu Val Gly Asp Gly Val Lys Arg
     50                  55                  60
 
gct att gat gaa gga ttg gtt aag aga gaa gaa atc ttt ttg act tct   240
Ala Ile Asp Glu Gly Leu Val Lys Arg Glu Glu Ile Phe Leu Thr Ser
 65                  70                  75                  80
 
aaa ttg tgg aat aat tat cat gat cct aaa aat gtt gaa act gct tta   288
Lys Leu Trp Asn Asn Tyr His Asp Pro Lys Asn Val Glu Thr Ala Leu
                 85                  90                  95
 
aat aaa act tta gct gat tta aaa gtt gat tat gtt gat ttg ttt ttg   336
Asn Lys Thr Leu Ala Asp Leu Lys Val Asp Tyr Val Asp Leu Phe Leu
            100                 105                 110
 
att cat ttt cca att gct ttt aaa ttt gtg cca att gaa gaa aaa tac   384
Ile His Phe Pro Ile Ala Phe Lys Phe Val Pro Ile Glu Glu Lys Tyr
        115                 120                 125
 
cct cct gga ttt tat tgt gga gat gga aat aat ttt gtt tat gaa gat   432
Pro Pro Gly Phe Tyr Cys Gly Asp Gly Asn Asn Phe Val Tyr Glu Asp
    130                 135                 140
 
gtt cca atc tta gaa aca tgg aaa gct ctt gaa aaa ttg gtt gct gct   480
Val Pro Ile Leu Glu Thr Trp Lys Ala Leu Glu Lys Leu Val Ala Ala
145                 150                 155                 160
 
ggt aaa att aaa tct att gga gtt tct aat ttt cca ggt gct ttg ttg   528
Gly Lys Ile Lys Ser Ile Gly Val Ser Asn Phe Pro Gly Ala Leu Leu
                165                 170                 175
 
ttg gat ttg ttg aga gga gct act att aag cca gct gtg tta caa gtt   576
Leu Asp Leu Leu Arg Gly Ala Thr Ile Lys Pro Ala Val Leu Gln Val
            180                 185                 190
 
gaa cat cat cca tat ttg caa caa cct aaa ttg att gaa ttt gca caa   624
Glu His His Pro Tyr Leu Gln Gln Pro Lys Leu Ile Glu Phe Ala Gln
        195                 200                 205
 
aag gct ggt gtt act att act gct tat tct tct ttt ggt cca caa tct   672
Lys Ala Gly Val Thr Ile Thr Ala Tyr Ser Ser Phe Gly Pro Gln Ser
    210                 215                 220
 
ttt gtt gaa atg aat caa ggt aga gct tta aat act cca act tta ttc   720
Phe Val Glu Met Asn Gln Gly Arg Ala Leu Asn Thr Pro Thr Leu Phe
225                 230                 235                 240
 
gcc cat gat act att aag gct att gct gct aaa tat aat aag act cct   768
Ala His Asp Thr Ile Lys Ala Ile Ala Ala Lys Tyr Asn Lys Thr Pro
                245                 250                 255
 
gct gaa gtt ttg ttg aga tgg gct gct caa aga gga att gct gtt att   816
Ala Glu Val Leu Leu Arg Trp Ala Ala Gln Arg Gly Ile Ala Val Ile
            260                 265                 270
 
cca aaa tct aat ttg cca gaa aga ttg gtt caa aat aga tct ttt aat   864
Pro Lys Ser Asn Leu Pro Glu Arg Leu Val Gln Asn Arg Ser Phe Asn
        275                 280                 285
 
act ttt gat ttg act aaa gaa gat ttt gag gaa att gct aaa ttg gat   912
Thr Phe Asp Leu Thr Lys Glu Asp Phe Glu Glu Ile Ala Lys Leu Asp
    290                 295                 300
 
ata gga ttg aga ttt aat gat cct tgg gac tgg gat aac att cca att   960
Ile Gly Leu Arg Phe Asn Asp Pro Trp Asp Trp Asp Asn Ile Pro Ile
305                 310                 315                 320
 
ttt gtt                                                           966
Phe Val

 

<210> 280
<211> 322
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in P. pastoris

<400> 280
Met Ser Ala Ser Ile Pro Asp Ile Lys Leu Ser Ser Gly His Leu Met
 1               5                  10                  15      
Pro Ser Ile Gly Phe Gly Cys Trp Lys Leu Ala Asn Ala Thr Ala Gly
            20                  25                  30          
Glu Gln Val Tyr Gln Ala Ile Lys Ala Gly Tyr Arg Leu Phe Asp Gly
        35                  40                  45              
Ala Glu Asp Tyr Gly Asn Glu Lys Glu Val Gly Asp Gly Val Lys Arg
    50                  55                  60                  
Ala Ile Asp Glu Gly Leu Val Lys Arg Glu Glu Ile Phe Leu Thr Ser
65                  70                  75                  80  
Lys Leu Trp Asn Asn Tyr His Asp Pro Lys Asn Val Glu Thr Ala Leu
                85                  90                  95      
Asn Lys Thr Leu Ala Asp Leu Lys Val Asp Tyr Val Asp Leu Phe Leu
            100                 105                 110         
Ile His Phe Pro Ile Ala Phe Lys Phe Val Pro Ile Glu Glu Lys Tyr
        115                 120                 125             
Pro Pro Gly Phe Tyr Cys Gly Asp Gly Asn Asn Phe Val Tyr Glu Asp
    130                 135                 140                 
Val Pro Ile Leu Glu Thr Trp Lys Ala Leu Glu Lys Leu Val Ala Ala
145                 150                 155                 160 
Gly Lys Ile Lys Ser Ile Gly Val Ser Asn Phe Pro Gly Ala Leu Leu
                165                 170                 175     
Leu Asp Leu Leu Arg Gly Ala Thr Ile Lys Pro Ala Val Leu Gln Val
            180                 185                 190         
Glu His His Pro Tyr Leu Gln Gln Pro Lys Leu Ile Glu Phe Ala Gln
        195                 200                 205             
Lys Ala Gly Val Thr Ile Thr Ala Tyr Ser Ser Phe Gly Pro Gln Ser
    210                 215                 220                 
Phe Val Glu Met Asn Gln Gly Arg Ala Leu Asn Thr Pro Thr Leu Phe
225                 230                 235                 240 
Ala His Asp Thr Ile Lys Ala Ile Ala Ala Lys Tyr Asn Lys Thr Pro
                245                 250                 255     
Ala Glu Val Leu Leu Arg Trp Ala Ala Gln Arg Gly Ile Ala Val Ile
            260                 265                 270         
Pro Lys Ser Asn Leu Pro Glu Arg Leu Val Gln Asn Arg Ser Phe Asn
        275                 280                 285             
Thr Phe Asp Leu Thr Lys Glu Asp Phe Glu Glu Ile Ala Lys Leu Asp
    290                 295                 300                 
Ile Gly Leu Arg Phe Asn Asp Pro Trp Asp Trp Asp Asn Ile Pro Ile
305                 310                 315                 320 
Phe Val
        


<210> 281
<211> 994
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in P. pastoris

<220> 
<221> CDS            
<222> (15)...(980)

<400> 281
gaatactcca tatg atg tct gct tct att cct gac att aaa tta tct tct   50
                Met Ser Ala Ser Ile Pro Asp Ile Lys Leu Ser Ser
                 1               5                   10
 
gga cat ttg atg cca tct att gga ttt ggt tgt tgg aaa ttg gct aat   98
Gly His Leu Met Pro Ser Ile Gly Phe Gly Cys Trp Lys Leu Ala Asn
         15                  20                  25
 
gca act gct gga gaa caa gtt tat cag gct att aaa gct gga tat aga   146
Ala Thr Ala Gly Glu Gln Val Tyr Gln Ala Ile Lys Ala Gly Tyr Arg
     30                  35                  40
 
ttg ttt gat gga gct gaa gat tat gga aat gaa aaa gaa gtt gga gac   194
Leu Phe Asp Gly Ala Glu Asp Tyr Gly Asn Glu Lys Glu Val Gly Asp
 45                  50                  55                  60
 
ggt gtt aaa aga gct att gat gaa gga ttg gtt aag aga gaa gaa atc   242
Gly Val Lys Arg Ala Ile Asp Glu Gly Leu Val Lys Arg Glu Glu Ile
                 65                  70                  75
 
ttt ttg act tct aaa ttg tgg aat aat tat cat gat cct aaa aat gtt   290
Phe Leu Thr Ser Lys Leu Trp Asn Asn Tyr His Asp Pro Lys Asn Val
             80                  85                  90
 
gaa act gct tta aat aaa act tta gct gat tta aaa gtt gat tat gtt   338
Glu Thr Ala Leu Asn Lys Thr Leu Ala Asp Leu Lys Val Asp Tyr Val
         95                 100                 105
 
gat ttg ttt ttg att cat ttt cca att gct ttt aaa ttt gtg cca att   386
Asp Leu Phe Leu Ile His Phe Pro Ile Ala Phe Lys Phe Val Pro Ile
    110                 115                 120
 
gaa gaa aaa tac cct cct gga ttt tat tgt gga gat gga aat aat ttt   434
Glu Glu Lys Tyr Pro Pro Gly Phe Tyr Cys Gly Asp Gly Asn Asn Phe
125                 130                 135                 140
 
gtt tat gaa gat gtt cca atc tta gaa aca tgg aaa gct ctt gaa aaa   482
Val Tyr Glu Asp Val Pro Ile Leu Glu Thr Trp Lys Ala Leu Glu Lys
                145                 150                 155
 
ttg gtt gct gct ggt aaa att aaa tct att gga gtt tct aat ttt cca   530
Leu Val Ala Ala Gly Lys Ile Lys Ser Ile Gly Val Ser Asn Phe Pro
            160                 165                 170
 
ggt gct ttg ttg ttg gat ttg ttg aga gga gct act att aag cca gct   578
Gly Ala Leu Leu Leu Asp Leu Leu Arg Gly Ala Thr Ile Lys Pro Ala
        175                 180                 185
 
gtg tta caa gtt gaa cat cat cca tat ttg caa caa cct aaa ttg att   626
Val Leu Gln Val Glu His His Pro Tyr Leu Gln Gln Pro Lys Leu Ile
    190                 195                 200
 
gaa ttt gca caa aag gct ggt gtt act att act gct tat tct tct ttt   674
Glu Phe Ala Gln Lys Ala Gly Val Thr Ile Thr Ala Tyr Ser Ser Phe
205                 210                 215                 220
 
ggt cca caa tct ttt gtt gaa atg aat caa ggt aga gct tta aat act   722
Gly Pro Gln Ser Phe Val Glu Met Asn Gln Gly Arg Ala Leu Asn Thr
                225                 230                 235
 
cca act tta ttc gcc cat gat act att aag gct att gct gct aaa tat   770
Pro Thr Leu Phe Ala His Asp Thr Ile Lys Ala Ile Ala Ala Lys Tyr
            240                 245                 250
 
aat aag act cct gct gaa gtt ttg ttg aga tgg gct gct caa aga gga   818
Asn Lys Thr Pro Ala Glu Val Leu Leu Arg Trp Ala Ala Gln Arg Gly
        255                 260                 265
 
att gct gtt att cca aaa tct aat ttg cca gaa aga ttg gtt caa aat   866
Ile Ala Val Ile Pro Lys Ser Asn Leu Pro Glu Arg Leu Val Gln Asn
    270                 275                 280
 
aga tct ttt aat act ttt gat ttg act aaa gaa gat ttt gag gaa att   914
Arg Ser Phe Asn Thr Phe Asp Leu Thr Lys Glu Asp Phe Glu Glu Ile
285                 290                 295                 300
 
gct aaa ttg gat ata gga ttg aga ttt aat gat cct tgg gac tgg gat   962
Ala Lys Leu Asp Ile Gly Leu Arg Phe Asn Asp Pro Trp Asp Trp Asp
                305                 310                 315
 
aac att cca att ttt gtt actagtcagt gcct                           994
Asn Ile Pro Ile Phe Val
            320
 

<210> 282
<211> 322
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in P. pastoris

<400> 282
Met Ser Ala Ser Ile Pro Asp Ile Lys Leu Ser Ser Gly His Leu Met
 1               5                  10                  15      
Pro Ser Ile Gly Phe Gly Cys Trp Lys Leu Ala Asn Ala Thr Ala Gly
            20                  25                  30          
Glu Gln Val Tyr Gln Ala Ile Lys Ala Gly Tyr Arg Leu Phe Asp Gly
        35                  40                  45              
Ala Glu Asp Tyr Gly Asn Glu Lys Glu Val Gly Asp Gly Val Lys Arg
    50                  55                  60                  
Ala Ile Asp Glu Gly Leu Val Lys Arg Glu Glu Ile Phe Leu Thr Ser
65                  70                  75                  80  
Lys Leu Trp Asn Asn Tyr His Asp Pro Lys Asn Val Glu Thr Ala Leu
                85                  90                  95      
Asn Lys Thr Leu Ala Asp Leu Lys Val Asp Tyr Val Asp Leu Phe Leu
            100                 105                 110         
Ile His Phe Pro Ile Ala Phe Lys Phe Val Pro Ile Glu Glu Lys Tyr
        115                 120                 125             
Pro Pro Gly Phe Tyr Cys Gly Asp Gly Asn Asn Phe Val Tyr Glu Asp
    130                 135                 140                 
Val Pro Ile Leu Glu Thr Trp Lys Ala Leu Glu Lys Leu Val Ala Ala
145                 150                 155                 160 
Gly Lys Ile Lys Ser Ile Gly Val Ser Asn Phe Pro Gly Ala Leu Leu
                165                 170                 175     
Leu Asp Leu Leu Arg Gly Ala Thr Ile Lys Pro Ala Val Leu Gln Val
            180                 185                 190         
Glu His His Pro Tyr Leu Gln Gln Pro Lys Leu Ile Glu Phe Ala Gln
        195                 200                 205             
Lys Ala Gly Val Thr Ile Thr Ala Tyr Ser Ser Phe Gly Pro Gln Ser
    210                 215                 220                 
Phe Val Glu Met Asn Gln Gly Arg Ala Leu Asn Thr Pro Thr Leu Phe
225                 230                 235                 240 
Ala His Asp Thr Ile Lys Ala Ile Ala Ala Lys Tyr Asn Lys Thr Pro
                245                 250                 255     
Ala Glu Val Leu Leu Arg Trp Ala Ala Gln Arg Gly Ile Ala Val Ile
            260                 265                 270         
Pro Lys Ser Asn Leu Pro Glu Arg Leu Val Gln Asn Arg Ser Phe Asn
        275                 280                 285             
Thr Phe Asp Leu Thr Lys Glu Asp Phe Glu Glu Ile Ala Lys Leu Asp
    290                 295                 300                 
Ile Gly Leu Arg Phe Asn Asp Pro Trp Asp Trp Asp Asn Ile Pro Ile
305                 310                 315                 320 
Phe Val
        


<210> 283
<211> 988
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in P. pastoris

<220> 
<221> CDS            
<222> (12)...(977)

<400> 283
tactcaagct t atg tct gct tct att cct gac att aaa tta tct tct gga  50
             Met Ser Ala Ser Ile Pro Asp Ile Lys Leu Ser Ser Gly
              1               5                   10
 
cat ttg atg cca tct att gga ttt ggt tgt tgg aaa ttg gct aat gca   98
His Leu Met Pro Ser Ile Gly Phe Gly Cys Trp Lys Leu Ala Asn Ala
     15                  20                  25
 
act gct gga gaa caa gtt tat cag gct att aaa gct gga tat aga ttg   146
Thr Ala Gly Glu Gln Val Tyr Gln Ala Ile Lys Ala Gly Tyr Arg Leu
 30                  35                  40                  45
 
ttt gat gga gct gaa gat tat gga aat gaa aaa gaa gtt gga gac ggt   194
Phe Asp Gly Ala Glu Asp Tyr Gly Asn Glu Lys Glu Val Gly Asp Gly
                 50                  55                  60
 
gtt aaa aga gct att gat gaa gga ttg gtt aag aga gaa gaa atc ttt   242
Val Lys Arg Ala Ile Asp Glu Gly Leu Val Lys Arg Glu Glu Ile Phe
             65                  70                  75
 
ttg act tct aaa ttg tgg aat aat tat cat gat cct aaa aat gtt gaa   290
Leu Thr Ser Lys Leu Trp Asn Asn Tyr His Asp Pro Lys Asn Val Glu
         80                  85                  90
 
act gct tta aat aaa act tta gct gat tta aaa gtt gat tat gtt gat   338
Thr Ala Leu Asn Lys Thr Leu Ala Asp Leu Lys Val Asp Tyr Val Asp
     95                 100                 105
 
ttg ttt ttg att cat ttt cca att gct ttt aaa ttt gtg cca att gaa   386
Leu Phe Leu Ile His Phe Pro Ile Ala Phe Lys Phe Val Pro Ile Glu
110                 115                 120                 125
 
gaa aaa tac cct cct gga ttt tat tgt gga gat gga aat aat ttt gtt   434
Glu Lys Tyr Pro Pro Gly Phe Tyr Cys Gly Asp Gly Asn Asn Phe Val
                130                 135                 140
 
tat gaa gat gtt cca atc tta gaa aca tgg aaa gct ctt gaa aaa ttg   482
Tyr Glu Asp Val Pro Ile Leu Glu Thr Trp Lys Ala Leu Glu Lys Leu
            145                 150                 155
 
gtt gct gct ggt aaa att aaa tct att gga gtt tct aat ttt cca ggt   530
Val Ala Ala Gly Lys Ile Lys Ser Ile Gly Val Ser Asn Phe Pro Gly
        160                 165                 170
 
gct ttg ttg ttg gat ttg ttg aga gga gct act att aag cca gct gtg   578
Ala Leu Leu Leu Asp Leu Leu Arg Gly Ala Thr Ile Lys Pro Ala Val
    175                 180                 185
 
tta caa gtt gaa cat cat cca tat ttg caa caa cct aaa ttg att gaa   626
Leu Gln Val Glu His His Pro Tyr Leu Gln Gln Pro Lys Leu Ile Glu
190                 195                 200                 205
 
ttt gca caa aag gct ggt gtt act att act gct tat tct tct ttt ggt   674
Phe Ala Gln Lys Ala Gly Val Thr Ile Thr Ala Tyr Ser Ser Phe Gly
                210                 215                 220
 
cca caa tct ttt gtt gaa atg aat caa ggt aga gct tta aat act cca   722
Pro Gln Ser Phe Val Glu Met Asn Gln Gly Arg Ala Leu Asn Thr Pro
            225                 230                 235
 
act tta ttc gcc cat gat act att aag gct att gct gct aaa tat aat   770
Thr Leu Phe Ala His Asp Thr Ile Lys Ala Ile Ala Ala Lys Tyr Asn
        240                 245                 250
 
aag act cct gct gaa gtt ttg ttg aga tgg gct gct caa aga gga att   818
Lys Thr Pro Ala Glu Val Leu Leu Arg Trp Ala Ala Gln Arg Gly Ile
    255                 260                 265
 
gct gtt att cca aaa tct aat ttg cca gaa aga ttg gtt caa aat aga   866
Ala Val Ile Pro Lys Ser Asn Leu Pro Glu Arg Leu Val Gln Asn Arg
270                 275                 280                 285
 
tct ttt aat act ttt gat ttg act aaa gaa gat ttt gag gaa att gct   914
Ser Phe Asn Thr Phe Asp Leu Thr Lys Glu Asp Phe Glu Glu Ile Ala
                290                 295                 300
 
aaa ttg gat ata gga ttg aga ttt aat gat cct tgg gac tgg gat aac   962
Lys Leu Asp Ile Gly Leu Arg Phe Asn Asp Pro Trp Asp Trp Asp Asn
            305                 310                 315
 
att cca att ttt gtt gaattccgat g                                  988
Ile Pro Ile Phe Val
        320
 

<210> 284
<211> 322
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in P. pastoris

<400> 284
Met Ser Ala Ser Ile Pro Asp Ile Lys Leu Ser Ser Gly His Leu Met
 1               5                  10                  15      
Pro Ser Ile Gly Phe Gly Cys Trp Lys Leu Ala Asn Ala Thr Ala Gly
            20                  25                  30          
Glu Gln Val Tyr Gln Ala Ile Lys Ala Gly Tyr Arg Leu Phe Asp Gly
        35                  40                  45              
Ala Glu Asp Tyr Gly Asn Glu Lys Glu Val Gly Asp Gly Val Lys Arg
    50                  55                  60                  
Ala Ile Asp Glu Gly Leu Val Lys Arg Glu Glu Ile Phe Leu Thr Ser
65                  70                  75                  80  
Lys Leu Trp Asn Asn Tyr His Asp Pro Lys Asn Val Glu Thr Ala Leu
                85                  90                  95      
Asn Lys Thr Leu Ala Asp Leu Lys Val Asp Tyr Val Asp Leu Phe Leu
            100                 105                 110         
Ile His Phe Pro Ile Ala Phe Lys Phe Val Pro Ile Glu Glu Lys Tyr
        115                 120                 125             
Pro Pro Gly Phe Tyr Cys Gly Asp Gly Asn Asn Phe Val Tyr Glu Asp
    130                 135                 140                 
Val Pro Ile Leu Glu Thr Trp Lys Ala Leu Glu Lys Leu Val Ala Ala
145                 150                 155                 160 
Gly Lys Ile Lys Ser Ile Gly Val Ser Asn Phe Pro Gly Ala Leu Leu
                165                 170                 175     
Leu Asp Leu Leu Arg Gly Ala Thr Ile Lys Pro Ala Val Leu Gln Val
            180                 185                 190         
Glu His His Pro Tyr Leu Gln Gln Pro Lys Leu Ile Glu Phe Ala Gln
        195                 200                 205             
Lys Ala Gly Val Thr Ile Thr Ala Tyr Ser Ser Phe Gly Pro Gln Ser
    210                 215                 220                 
Phe Val Glu Met Asn Gln Gly Arg Ala Leu Asn Thr Pro Thr Leu Phe
225                 230                 235                 240 
Ala His Asp Thr Ile Lys Ala Ile Ala Ala Lys Tyr Asn Lys Thr Pro
                245                 250                 255     
Ala Glu Val Leu Leu Arg Trp Ala Ala Gln Arg Gly Ile Ala Val Ile
            260                 265                 270         
Pro Lys Ser Asn Leu Pro Glu Arg Leu Val Gln Asn Arg Ser Phe Asn
        275                 280                 285             
Thr Phe Asp Leu Thr Lys Glu Asp Phe Glu Glu Ile Ala Lys Leu Asp
    290                 295                 300                 
Ile Gly Leu Arg Phe Asn Asp Pro Trp Asp Trp Asp Asn Ile Pro Ile
305                 310                 315                 320 
Phe Val
        


<210> 285
<211> 966
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in K. lactis

<220> 
<221> CDS            
<222> (1)...(966)

<400> 285
atg tct gct tct att cca gat ata aaa ttg tct tct ggt cat ttg atg   48
Met Ser Ala Ser Ile Pro Asp Ile Lys Leu Ser Ser Gly His Leu Met
 1               5                   10                  15
 
cca tct att ggt ttc ggt tgt tgg aaa ttg gct aat gct act gct ggt   96
Pro Ser Ile Gly Phe Gly Cys Trp Lys Leu Ala Asn Ala Thr Ala Gly
             20                  25                  30
 
gaa caa gtt tat caa gct att aaa gcg ggt tat aga ttg ttc gat ggt   144
Glu Gln Val Tyr Gln Ala Ile Lys Ala Gly Tyr Arg Leu Phe Asp Gly
         35                  40                  45
 
gct gaa gat tat ggt aat gaa aaa gaa gtt ggt gat ggt gtt aaa aga   192
Ala Glu Asp Tyr Gly Asn Glu Lys Glu Val Gly Asp Gly Val Lys Arg
     50                  55                  60
 
gct att gat gaa ggt ttg gtt aaa aga gaa gaa att ttc ttg act tct   240
Ala Ile Asp Glu Gly Leu Val Lys Arg Glu Glu Ile Phe Leu Thr Ser
 65                  70                  75                  80
 
aaa ttg tgg aat aat tat cat gat cca aag aat gtt gaa act gct tta   288
Lys Leu Trp Asn Asn Tyr His Asp Pro Lys Asn Val Glu Thr Ala Leu
                 85                  90                  95
 
aat aaa act tta gct gat tta aag gtt gat tat gtt gat ttg ttc ttg   336
Asn Lys Thr Leu Ala Asp Leu Lys Val Asp Tyr Val Asp Leu Phe Leu
            100                 105                 110
 
att cac ttc cct att gct ttc aaa ttc gtt cca att gaa gaa aaa tat   384
Ile His Phe Pro Ile Ala Phe Lys Phe Val Pro Ile Glu Glu Lys Tyr
        115                 120                 125
 
cca cca ggt ttc tat tgt ggt gac ggc aat aat ttc gtt tat gaa gat   432
Pro Pro Gly Phe Tyr Cys Gly Asp Gly Asn Asn Phe Val Tyr Glu Asp
    130                 135                 140
 
gtt cca atc ttg gaa act tgg aag gct ttg gaa aaa ttg gtt gct gcc   480
Val Pro Ile Leu Glu Thr Trp Lys Ala Leu Glu Lys Leu Val Ala Ala
145                 150                 155                 160
 
ggg aag att aaa tct att ggt gtt tct aat ttc cct ggc gca cta ttg   528
Gly Lys Ile Lys Ser Ile Gly Val Ser Asn Phe Pro Gly Ala Leu Leu
                165                 170                 175
 
ttg gat ttg ttg aga ggt gct act att aaa cct gca gtt ctc caa gtt   576
Leu Asp Leu Leu Arg Gly Ala Thr Ile Lys Pro Ala Val Leu Gln Val
            180                 185                 190
 
gaa cat cat cca tat ctt caa cag cct aaa ttg att gaa ttt gcg cag   624
Glu His His Pro Tyr Leu Gln Gln Pro Lys Leu Ile Glu Phe Ala Gln
        195                 200                 205
 
aaa gca ggc gtt act att act gcc tat tct tct ttc ggt cca caa tct   672
Lys Ala Gly Val Thr Ile Thr Ala Tyr Ser Ser Phe Gly Pro Gln Ser
    210                 215                 220
 
ttc gtt gaa atg aat caa ggt aga gct tta aac act cca aca ttg ttc   720
Phe Val Glu Met Asn Gln Gly Arg Ala Leu Asn Thr Pro Thr Leu Phe
225                 230                 235                 240
 
gct cat gat act att aaa gct att gca gct aaa tat aat aaa act cca   768
Ala His Asp Thr Ile Lys Ala Ile Ala Ala Lys Tyr Asn Lys Thr Pro
                245                 250                 255
 
gcc gaa gta cta ttg aga tgg gct gct caa aga gga att gct gtt att   816
Ala Glu Val Leu Leu Arg Trp Ala Ala Gln Arg Gly Ile Ala Val Ile
            260                 265                 270
 
cca aaa tct aat ttg cca gaa aga ttg gtt caa aat aga tct ttc aat   864
Pro Lys Ser Asn Leu Pro Glu Arg Leu Val Gln Asn Arg Ser Phe Asn
        275                 280                 285
 
act ttc gat ttg act aaa gaa gat ttc gag gag att gct aaa ttg gac   912
Thr Phe Asp Leu Thr Lys Glu Asp Phe Glu Glu Ile Ala Lys Leu Asp
    290                 295                 300
 
att ggt ttg aga ttc aat gat cca tgg gat tgg gat aat att cca att   960
Ile Gly Leu Arg Phe Asn Asp Pro Trp Asp Trp Asp Asn Ile Pro Ile
305                 310                 315                 320
 
ttc gtt                                                           966
Phe Val

 

<210> 286
<211> 322
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in K. lactis

<400> 286
Met Ser Ala Ser Ile Pro Asp Ile Lys Leu Ser Ser Gly His Leu Met
 1               5                  10                  15      
Pro Ser Ile Gly Phe Gly Cys Trp Lys Leu Ala Asn Ala Thr Ala Gly
            20                  25                  30          
Glu Gln Val Tyr Gln Ala Ile Lys Ala Gly Tyr Arg Leu Phe Asp Gly
        35                  40                  45              
Ala Glu Asp Tyr Gly Asn Glu Lys Glu Val Gly Asp Gly Val Lys Arg
    50                  55                  60                  
Ala Ile Asp Glu Gly Leu Val Lys Arg Glu Glu Ile Phe Leu Thr Ser
65                  70                  75                  80  
Lys Leu Trp Asn Asn Tyr His Asp Pro Lys Asn Val Glu Thr Ala Leu
                85                  90                  95      
Asn Lys Thr Leu Ala Asp Leu Lys Val Asp Tyr Val Asp Leu Phe Leu
            100                 105                 110         
Ile His Phe Pro Ile Ala Phe Lys Phe Val Pro Ile Glu Glu Lys Tyr
        115                 120                 125             
Pro Pro Gly Phe Tyr Cys Gly Asp Gly Asn Asn Phe Val Tyr Glu Asp
    130                 135                 140                 
Val Pro Ile Leu Glu Thr Trp Lys Ala Leu Glu Lys Leu Val Ala Ala
145                 150                 155                 160 
Gly Lys Ile Lys Ser Ile Gly Val Ser Asn Phe Pro Gly Ala Leu Leu
                165                 170                 175     
Leu Asp Leu Leu Arg Gly Ala Thr Ile Lys Pro Ala Val Leu Gln Val
            180                 185                 190         
Glu His His Pro Tyr Leu Gln Gln Pro Lys Leu Ile Glu Phe Ala Gln
        195                 200                 205             
Lys Ala Gly Val Thr Ile Thr Ala Tyr Ser Ser Phe Gly Pro Gln Ser
    210                 215                 220                 
Phe Val Glu Met Asn Gln Gly Arg Ala Leu Asn Thr Pro Thr Leu Phe
225                 230                 235                 240 
Ala His Asp Thr Ile Lys Ala Ile Ala Ala Lys Tyr Asn Lys Thr Pro
                245                 250                 255     
Ala Glu Val Leu Leu Arg Trp Ala Ala Gln Arg Gly Ile Ala Val Ile
            260                 265                 270         
Pro Lys Ser Asn Leu Pro Glu Arg Leu Val Gln Asn Arg Ser Phe Asn
        275                 280                 285             
Thr Phe Asp Leu Thr Lys Glu Asp Phe Glu Glu Ile Ala Lys Leu Asp
    290                 295                 300                 
Ile Gly Leu Arg Phe Asn Asp Pro Trp Asp Trp Asp Asn Ile Pro Ile
305                 310                 315                 320 
Phe Val
        


<210> 287
<211> 966
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in Z. mobilis

<220> 
<221> CDS            
<222> (1)...(966)

<400> 287
atg tct gcc tct att ccg gac att aaa ttg tct tct ggt cat ctt atg   48
Met Ser Ala Ser Ile Pro Asp Ile Lys Leu Ser Ser Gly His Leu Met
 1               5                   10                  15
 
ccg tct att ggt ttt ggt tgt tgg aaa ttg gct aat gct aca gcg ggt   96
Pro Ser Ile Gly Phe Gly Cys Trp Lys Leu Ala Asn Ala Thr Ala Gly
             20                  25                  30
 
gaa cag gtt tat cag gcc att aaa gct ggt tat cgt ttg ttt gat ggt   144
Glu Gln Val Tyr Gln Ala Ile Lys Ala Gly Tyr Arg Leu Phe Asp Gly
         35                  40                  45
 
gcc gaa gat tat ggt aat gaa aaa gaa gtt ggt gat ggt gtt aaa cgt   192
Ala Glu Asp Tyr Gly Asn Glu Lys Glu Val Gly Asp Gly Val Lys Arg
     50                  55                  60
 
gcc att gat gaa ggt ttg gtt aaa cgc gaa gag ata ttc ttg acc tct   240
Ala Ile Asp Glu Gly Leu Val Lys Arg Glu Glu Ile Phe Leu Thr Ser
 65                  70                  75                  80
 
aaa ttg tgg aat aat tat cat gat ccg aaa aat gtt gaa acc gct ctt   288
Lys Leu Trp Asn Asn Tyr His Asp Pro Lys Asn Val Glu Thr Ala Leu
                 85                  90                  95
 
aat aaa acc ttg gcc gat ttg aaa gtt gat tat gtt gat ttg ttt ttg   336
Asn Lys Thr Leu Ala Asp Leu Lys Val Asp Tyr Val Asp Leu Phe Leu
            100                 105                 110
 
att cat ttt ccg att gcc ttc aaa ttt gtt ccg atc gaa gaa aaa tat   384
Ile His Phe Pro Ile Ala Phe Lys Phe Val Pro Ile Glu Glu Lys Tyr
        115                 120                 125
 
ccg cct ggt ttt tat tgt ggt gac gga aat aat ttt gtt tat gaa gat   432
Pro Pro Gly Phe Tyr Cys Gly Asp Gly Asn Asn Phe Val Tyr Glu Asp
    130                 135                 140
 
gtt cca atc ttg gaa acc tgg aaa gct ctt gaa aaa ttg gtt gca gct   480
Val Pro Ile Leu Glu Thr Trp Lys Ala Leu Glu Lys Leu Val Ala Ala
145                 150                 155                 160
 
ggc aaa att aaa tct att ggt gtt tct aat ttt ccg ggt gct ctt ttg   528
Gly Lys Ile Lys Ser Ile Gly Val Ser Asn Phe Pro Gly Ala Leu Leu
                165                 170                 175
 
ttg gat ttg ttg cgt ggt gct aca att aaa ccg gca gtg ttg cag gtt   576
Leu Asp Leu Leu Arg Gly Ala Thr Ile Lys Pro Ala Val Leu Gln Val
            180                 185                 190
 
gaa cat cat ccg tat ttg cag cag ccg aaa ttg att gaa ttt gcc cag   624
Glu His His Pro Tyr Leu Gln Gln Pro Lys Leu Ile Glu Phe Ala Gln
        195                 200                 205
 
aag gct gga gtg acc att acc gct tat tct tct ttt ggt ccg cag tct   672
Lys Ala Gly Val Thr Ile Thr Ala Tyr Ser Ser Phe Gly Pro Gln Ser
    210                 215                 220
 
ttt gtt gaa atg aat cag ggt cgt gct ctt aat acc ccg acc ttg ttt   720
Phe Val Glu Met Asn Gln Gly Arg Ala Leu Asn Thr Pro Thr Leu Phe
225                 230                 235                 240
 
gcg cat gat acc att aaa gcc att gcg gcg aaa tat aat aaa acc cct   768
Ala His Asp Thr Ile Lys Ala Ile Ala Ala Lys Tyr Asn Lys Thr Pro
                245                 250                 255
 
gct gag gta ctg ttg aga tgg gca gca cag aga ggc ata gcg gtc att   816
Ala Glu Val Leu Leu Arg Trp Ala Ala Gln Arg Gly Ile Ala Val Ile
            260                 265                 270
 
ccg aaa tct aat ttg cct gaa cgt ttg gtt cag aat cgt tct ttt aat   864
Pro Lys Ser Asn Leu Pro Glu Arg Leu Val Gln Asn Arg Ser Phe Asn
        275                 280                 285
 
acc ttt gat ttg acc aaa gaa gat ttt gaa gaa att gcc aaa ttg gat   912
Thr Phe Asp Leu Thr Lys Glu Asp Phe Glu Glu Ile Ala Lys Leu Asp
    290                 295                 300
 
ata ggt ttg cgt ttt aat gat ccg tgg gat tgg gat aat att ccg att   960
Ile Gly Leu Arg Phe Asn Asp Pro Trp Asp Trp Asp Asn Ile Pro Ile
305                 310                 315                 320
 
ttt gtt                                                           966
Phe Val

 

<210> 288
<211> 322
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in Z. mobilis

<400> 288
Met Ser Ala Ser Ile Pro Asp Ile Lys Leu Ser Ser Gly His Leu Met
 1               5                  10                  15      
Pro Ser Ile Gly Phe Gly Cys Trp Lys Leu Ala Asn Ala Thr Ala Gly
            20                  25                  30          
Glu Gln Val Tyr Gln Ala Ile Lys Ala Gly Tyr Arg Leu Phe Asp Gly
        35                  40                  45              
Ala Glu Asp Tyr Gly Asn Glu Lys Glu Val Gly Asp Gly Val Lys Arg
    50                  55                  60                  
Ala Ile Asp Glu Gly Leu Val Lys Arg Glu Glu Ile Phe Leu Thr Ser
65                  70                  75                  80  
Lys Leu Trp Asn Asn Tyr His Asp Pro Lys Asn Val Glu Thr Ala Leu
                85                  90                  95      
Asn Lys Thr Leu Ala Asp Leu Lys Val Asp Tyr Val Asp Leu Phe Leu
            100                 105                 110         
Ile His Phe Pro Ile Ala Phe Lys Phe Val Pro Ile Glu Glu Lys Tyr
        115                 120                 125             
Pro Pro Gly Phe Tyr Cys Gly Asp Gly Asn Asn Phe Val Tyr Glu Asp
    130                 135                 140                 
Val Pro Ile Leu Glu Thr Trp Lys Ala Leu Glu Lys Leu Val Ala Ala
145                 150                 155                 160 
Gly Lys Ile Lys Ser Ile Gly Val Ser Asn Phe Pro Gly Ala Leu Leu
                165                 170                 175     
Leu Asp Leu Leu Arg Gly Ala Thr Ile Lys Pro Ala Val Leu Gln Val
            180                 185                 190         
Glu His His Pro Tyr Leu Gln Gln Pro Lys Leu Ile Glu Phe Ala Gln
        195                 200                 205             
Lys Ala Gly Val Thr Ile Thr Ala Tyr Ser Ser Phe Gly Pro Gln Ser
    210                 215                 220                 
Phe Val Glu Met Asn Gln Gly Arg Ala Leu Asn Thr Pro Thr Leu Phe
225                 230                 235                 240 
Ala His Asp Thr Ile Lys Ala Ile Ala Ala Lys Tyr Asn Lys Thr Pro
                245                 250                 255     
Ala Glu Val Leu Leu Arg Trp Ala Ala Gln Arg Gly Ile Ala Val Ile
            260                 265                 270         
Pro Lys Ser Asn Leu Pro Glu Arg Leu Val Gln Asn Arg Ser Phe Asn
        275                 280                 285             
Thr Phe Asp Leu Thr Lys Glu Asp Phe Glu Glu Ile Ala Lys Leu Asp
    290                 295                 300                 
Ile Gly Leu Arg Phe Asn Asp Pro Trp Asp Trp Asp Asn Ile Pro Ile
305                 310                 315                 320 
Phe Val
        


<210> 289
<211> 1491
<212> DNA
<213> B. subtilis

<220> 
<221> CDS            
<222> (1)...(1491)

<400> 289
atg ctt cag aca aag gat tat gaa ttc tgg ttt gtg aca gga agc cag   48
Met Leu Gln Thr Lys Asp Tyr Glu Phe Trp Phe Val Thr Gly Ser Gln
 1               5                   10                  15
 
cac cta tac ggg gaa gag acg ctg gaa ctc gta gat cag cat gct aaa   96
His Leu Tyr Gly Glu Glu Thr Leu Glu Leu Val Asp Gln His Ala Lys
             20                  25                  30
 
agc att tgt gag ggg ctc agc ggg att tct tcc aga tat aaa atc act   144
Ser Ile Cys Glu Gly Leu Ser Gly Ile Ser Ser Arg Tyr Lys Ile Thr
         35                  40                  45
 
cat aag ccc gtc gtc act tca ccg gaa acc att aga gag ctg tta aga   192
His Lys Pro Val Val Thr Ser Pro Glu Thr Ile Arg Glu Leu Leu Arg
     50                  55                  60
 
gaa gcg gag tac agt gag aca tgt gct ggc atc att aca tgg atg cac   240
Glu Ala Glu Tyr Ser Glu Thr Cys Ala Gly Ile Ile Thr Trp Met His
 65                  70                  75                  80
 
aca ttt tcc cct gca aaa atg tgg ata gaa ggc ctt tcc tct tat caa   288
Thr Phe Ser Pro Ala Lys Met Trp Ile Glu Gly Leu Ser Ser Tyr Gln
                 85                  90                  95
 
aaa ccg ctt atg cat ttg cat acc caa tat aat cgc gat atc ccg tgg   336
Lys Pro Leu Met His Leu His Thr Gln Tyr Asn Arg Asp Ile Pro Trp
            100                 105                 110
 
ggt acg att gac atg gat ttt atg aac agc aac caa tcc gcg cat ggc   384
Gly Thr Ile Asp Met Asp Phe Met Asn Ser Asn Gln Ser Ala His Gly
        115                 120                 125
 
gat cga gag tac ggt tac atc aac tcg aga atg ggg ctt agc cga aaa   432
Asp Arg Glu Tyr Gly Tyr Ile Asn Ser Arg Met Gly Leu Ser Arg Lys
    130                 135                 140
 
gtc att gcc ggc tat tgg gat gat gaa gaa gtg aaa aaa gaa atg tcc   480
Val Ile Ala Gly Tyr Trp Asp Asp Glu Glu Val Lys Lys Glu Met Ser
145                 150                 155                 160
 
cag tgg atg gat acg gcg gct gca tta aat gaa agc aga cat att aag   528
Gln Trp Met Asp Thr Ala Ala Ala Leu Asn Glu Ser Arg His Ile Lys
                165                 170                 175
 
gtt gcc aga ttt gga gat aac atg cgt cat gtc gcg gta acg gac gga   576
Val Ala Arg Phe Gly Asp Asn Met Arg His Val Ala Val Thr Asp Gly
            180                 185                 190
 
gac aag gtg gga gcg cat att caa ttt ggc tgg cag gtt gac gga tat   624
Asp Lys Val Gly Ala His Ile Gln Phe Gly Trp Gln Val Asp Gly Tyr
        195                 200                 205
 
ggc atc ggg gat ctc gtt gaa gtg atg gat cgc att acg gac gac gag   672
Gly Ile Gly Asp Leu Val Glu Val Met Asp Arg Ile Thr Asp Asp Glu
    210                 215                 220
 
gtt gac acg ctt tat gcc gag tat gac aga cta tat gtg atc agt gag   720
Val Asp Thr Leu Tyr Ala Glu Tyr Asp Arg Leu Tyr Val Ile Ser Glu
225                 230                 235                 240
 
gaa aca aaa cgt gac gaa gca aag gta gcg tcc att aaa gaa cag gcg   768
Glu Thr Lys Arg Asp Glu Ala Lys Val Ala Ser Ile Lys Glu Gln Ala
                245                 250                 255
 
aaa att gaa ctt gga tta acc gct ttt ctt gag caa ggc gga tac aca   816
Lys Ile Glu Leu Gly Leu Thr Ala Phe Leu Glu Gln Gly Gly Tyr Thr
            260                 265                 270
 
gcg ttt acg aca tcg ttt gaa gtg ctg cac gga atg aaa cag ctg ccg   864
Ala Phe Thr Thr Ser Phe Glu Val Leu His Gly Met Lys Gln Leu Pro
        275                 280                 285
 
gga ctt gcc gtt cag cgc ctg atg gag aaa ggc tat ggg ttt gcc ggt   912
Gly Leu Ala Val Gln Arg Leu Met Glu Lys Gly Tyr Gly Phe Ala Gly
    290                 295                 300
 
gaa gga gat tgg aag aca gcg gcc ctt gta cgg atg atg aaa atc atg   960
Glu Gly Asp Trp Lys Thr Ala Ala Leu Val Arg Met Met Lys Ile Met
305                 310                 315                 320
 
gct aaa gga aaa aga act tcc ttc atg gaa gat tac acg tac cat ttt   1008
Ala Lys Gly Lys Arg Thr Ser Phe Met Glu Asp Tyr Thr Tyr His Phe
                325                 330                 335
 
gaa ccg gga aat gaa atg att ctg ggc tct cac atg ctt gaa gtg tgt   1056
Glu Pro Gly Asn Glu Met Ile Leu Gly Ser His Met Leu Glu Val Cys
            340                 345                 350
 
ccg act gtc gct ttg gat cag ccg aaa atc gag gtt cat tcg ctt tcg   1104
Pro Thr Val Ala Leu Asp Gln Pro Lys Ile Glu Val His Ser Leu Ser
        355                 360                 365
 
att ggc ggc aaa gag gac cct gcg cgt ttg gta ttt aac ggc atc agc   1152
Ile Gly Gly Lys Glu Asp Pro Ala Arg Leu Val Phe Asn Gly Ile Ser
    370                 375                 380
 
ggt tct gcc att caa gct agc att gtt gat att ggc ggg cgt ttc cgc   1200
Gly Ser Ala Ile Gln Ala Ser Ile Val Asp Ile Gly Gly Arg Phe Arg
385                 390                 395                 400
 
ctt gtg ctg aat gaa gtc aac ggc cag gaa att gaa aaa gac atg ccg   1248
Leu Val Leu Asn Glu Val Asn Gly Gln Glu Ile Glu Lys Asp Met Pro
                405                 410                 415
 
aat tta ccg gtt gcc cgt gtt ctc tgg aag ccg gag ccg tca ttg aaa   1296
Asn Leu Pro Val Ala Arg Val Leu Trp Lys Pro Glu Pro Ser Leu Lys
            420                 425                 430
 
aca gca gcg gag gca tgg att tta gcc ggc ggt gca cac cat acc tgc   1344
Thr Ala Ala Glu Ala Trp Ile Leu Ala Gly Gly Ala His His Thr Cys
        435                 440                 445
 
ctg tct tat gaa ctg aca gcg gag caa atg ctt gat tgg gcg gaa atg   1392
Leu Ser Tyr Glu Leu Thr Ala Glu Gln Met Leu Asp Trp Ala Glu Met
    450                 455                 460
 
gcg gga atc gaa agt gtt ctc att tcc cgt gat acg aca att cat aaa   1440
Ala Gly Ile Glu Ser Val Leu Ile Ser Arg Asp Thr Thr Ile His Lys
465                 470                 475                 480
 
ctg aaa cac gag tta aaa tgg aac gag gcg ctt tac cgg ctt caa aag   1488
Leu Lys His Glu Leu Lys Trp Asn Glu Ala Leu Tyr Arg Leu Gln Lys
                485                 490                 495
 
tag                                                               1491
 *

 

<210> 290
<211> 496
<212> PRT
<213> B. subtilis

<400> 290
Met Leu Gln Thr Lys Asp Tyr Glu Phe Trp Phe Val Thr Gly Ser Gln
 1               5                  10                  15      
His Leu Tyr Gly Glu Glu Thr Leu Glu Leu Val Asp Gln His Ala Lys
            20                  25                  30          
Ser Ile Cys Glu Gly Leu Ser Gly Ile Ser Ser Arg Tyr Lys Ile Thr
        35                  40                  45              
His Lys Pro Val Val Thr Ser Pro Glu Thr Ile Arg Glu Leu Leu Arg
    50                  55                  60                  
Glu Ala Glu Tyr Ser Glu Thr Cys Ala Gly Ile Ile Thr Trp Met His
65                  70                  75                  80  
Thr Phe Ser Pro Ala Lys Met Trp Ile Glu Gly Leu Ser Ser Tyr Gln
                85                  90                  95      
Lys Pro Leu Met His Leu His Thr Gln Tyr Asn Arg Asp Ile Pro Trp
            100                 105                 110         
Gly Thr Ile Asp Met Asp Phe Met Asn Ser Asn Gln Ser Ala His Gly
        115                 120                 125             
Asp Arg Glu Tyr Gly Tyr Ile Asn Ser Arg Met Gly Leu Ser Arg Lys
    130                 135                 140                 
Val Ile Ala Gly Tyr Trp Asp Asp Glu Glu Val Lys Lys Glu Met Ser
145                 150                 155                 160 
Gln Trp Met Asp Thr Ala Ala Ala Leu Asn Glu Ser Arg His Ile Lys
                165                 170                 175     
Val Ala Arg Phe Gly Asp Asn Met Arg His Val Ala Val Thr Asp Gly
            180                 185                 190         
Asp Lys Val Gly Ala His Ile Gln Phe Gly Trp Gln Val Asp Gly Tyr
        195                 200                 205             
Gly Ile Gly Asp Leu Val Glu Val Met Asp Arg Ile Thr Asp Asp Glu
    210                 215                 220                 
Val Asp Thr Leu Tyr Ala Glu Tyr Asp Arg Leu Tyr Val Ile Ser Glu
225                 230                 235                 240 
Glu Thr Lys Arg Asp Glu Ala Lys Val Ala Ser Ile Lys Glu Gln Ala
                245                 250                 255     
Lys Ile Glu Leu Gly Leu Thr Ala Phe Leu Glu Gln Gly Gly Tyr Thr
            260                 265                 270         
Ala Phe Thr Thr Ser Phe Glu Val Leu His Gly Met Lys Gln Leu Pro
        275                 280                 285             
Gly Leu Ala Val Gln Arg Leu Met Glu Lys Gly Tyr Gly Phe Ala Gly
    290                 295                 300                 
Glu Gly Asp Trp Lys Thr Ala Ala Leu Val Arg Met Met Lys Ile Met
305                 310                 315                 320 
Ala Lys Gly Lys Arg Thr Ser Phe Met Glu Asp Tyr Thr Tyr His Phe
                325                 330                 335     
Glu Pro Gly Asn Glu Met Ile Leu Gly Ser His Met Leu Glu Val Cys
            340                 345                 350         
Pro Thr Val Ala Leu Asp Gln Pro Lys Ile Glu Val His Ser Leu Ser
        355                 360                 365             
Ile Gly Gly Lys Glu Asp Pro Ala Arg Leu Val Phe Asn Gly Ile Ser
    370                 375                 380                 
Gly Ser Ala Ile Gln Ala Ser Ile Val Asp Ile Gly Gly Arg Phe Arg
385                 390                 395                 400 
Leu Val Leu Asn Glu Val Asn Gly Gln Glu Ile Glu Lys Asp Met Pro
                405                 410                 415     
Asn Leu Pro Val Ala Arg Val Leu Trp Lys Pro Glu Pro Ser Leu Lys
            420                 425                 430         
Thr Ala Ala Glu Ala Trp Ile Leu Ala Gly Gly Ala His His Thr Cys
        435                 440                 445             
Leu Ser Tyr Glu Leu Thr Ala Glu Gln Met Leu Asp Trp Ala Glu Met
    450                 455                 460                 
Ala Gly Ile Glu Ser Val Leu Ile Ser Arg Asp Thr Thr Ile His Lys
465                 470                 475                 480 
Leu Lys His Glu Leu Lys Trp Asn Glu Ala Leu Tyr Arg Leu Gln Lys
                485                 490                 495     


<210> 291
<211> 1488
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in S. cerevisiae

<220> 
<221> CDS            
<222> (1)...(1488)

<400> 291
atg ttg caa act aaa gat tat gaa ttt tgg ttt gta act ggt tct cag   48
Met Leu Gln Thr Lys Asp Tyr Glu Phe Trp Phe Val Thr Gly Ser Gln
 1               5                   10                  15
 
cat ttg tat ggt gaa gaa aca tta gaa ttg gtt gat cag cac gcg aaa   96
His Leu Tyr Gly Glu Glu Thr Leu Glu Leu Val Asp Gln His Ala Lys
             20                  25                  30
 
tct att tgt gaa gga tta tca gga att tct tct agg tat aaa att act   144
Ser Ile Cys Glu Gly Leu Ser Gly Ile Ser Ser Arg Tyr Lys Ile Thr
         35                  40                  45
 
cat aaa cca gtt gtt act tca ccc gaa act att aga gaa ttg ttg aga   192
His Lys Pro Val Val Thr Ser Pro Glu Thr Ile Arg Glu Leu Leu Arg
     50                  55                  60
 
gaa gct gaa tat tct gaa act tgt gct gga att att act tgg atg cat   240
Glu Ala Glu Tyr Ser Glu Thr Cys Ala Gly Ile Ile Thr Trp Met His
 65                  70                  75                  80
 
act ttt tca cca gct aaa atg tgg att gaa gga tta agt tct tat caa   288
Thr Phe Ser Pro Ala Lys Met Trp Ile Glu Gly Leu Ser Ser Tyr Gln
                 85                  90                  95
 
aaa cca ttg atg cat ttg cat act caa tat aat aga gac att cca tgg   336
Lys Pro Leu Met His Leu His Thr Gln Tyr Asn Arg Asp Ile Pro Trp
            100                 105                 110
 
ggt act att gat atg gat ttt atg aac tct aat caa tct gct cat ggt   384
Gly Thr Ile Asp Met Asp Phe Met Asn Ser Asn Gln Ser Ala His Gly
        115                 120                 125
 
gat aga gaa tat ggt tat att aat tca agg atg ggt ttg tct agg aag   432
Asp Arg Glu Tyr Gly Tyr Ile Asn Ser Arg Met Gly Leu Ser Arg Lys
    130                 135                 140
 
gta att gct ggt tat tgg gat gat gaa gaa gtt aag aag gaa atg tca   480
Val Ile Ala Gly Tyr Trp Asp Asp Glu Glu Val Lys Lys Glu Met Ser
145                 150                 155                 160
 
caa tgg atg gat acc gct gct gct tta aac gaa tcc aga cat att aag   528
Gln Trp Met Asp Thr Ala Ala Ala Leu Asn Glu Ser Arg His Ile Lys
                165                 170                 175
 
gtt gct aga ttc ggt gat aat atg aga cat gtt gct gtt act gat ggt   576
Val Ala Arg Phe Gly Asp Asn Met Arg His Val Ala Val Thr Asp Gly
            180                 185                 190
 
gat aaa gta ggt gct cat att cag ttc ggt tgg caa gtt gat ggt tat   624
Asp Lys Val Gly Ala His Ile Gln Phe Gly Trp Gln Val Asp Gly Tyr
        195                 200                 205
 
gga att ggt gat ttg gtt gaa gtt atg gat aga att act gat gat gag   672
Gly Ile Gly Asp Leu Val Glu Val Met Asp Arg Ile Thr Asp Asp Glu
    210                 215                 220
 
gtt gat act cta tat gct gaa tat gat aga ttg tat gta att tct gaa   720
Val Asp Thr Leu Tyr Ala Glu Tyr Asp Arg Leu Tyr Val Ile Ser Glu
225                 230                 235                 240
 
gaa act aaa aga gat gaa gct aaa gta gct agc att aaa gaa caa gct   768
Glu Thr Lys Arg Asp Glu Ala Lys Val Ala Ser Ile Lys Glu Gln Ala
                245                 250                 255
 
aaa att gaa ttg ggt ctg act gct ttc ttg gaa caa ggt ggt tat act   816
Lys Ile Glu Leu Gly Leu Thr Ala Phe Leu Glu Gln Gly Gly Tyr Thr
            260                 265                 270
 
gct ttt act act tct ttt gaa gtt ttg cat ggt atg aaa caa ttg cca   864
Ala Phe Thr Thr Ser Phe Glu Val Leu His Gly Met Lys Gln Leu Pro
        275                 280                 285
 
ggt ttg gct gtt caa aga ttg atg gaa aaa ggt tat ggt ttt gca gga   912
Gly Leu Ala Val Gln Arg Leu Met Glu Lys Gly Tyr Gly Phe Ala Gly
    290                 295                 300
 
gag ggt gat tgg aaa aca gct gct cta gtt aga atg atg aaa att atg   960
Glu Gly Asp Trp Lys Thr Ala Ala Leu Val Arg Met Met Lys Ile Met
305                 310                 315                 320
 
gct aaa ggt aaa aga act tct ttc atg gaa gat tat act tat cat ttt   1008
Ala Lys Gly Lys Arg Thr Ser Phe Met Glu Asp Tyr Thr Tyr His Phe
                325                 330                 335
 
gaa cca ggt aat gaa atg att ttg ggt tct cac atg ttg gaa gtt tgt   1056
Glu Pro Gly Asn Glu Met Ile Leu Gly Ser His Met Leu Glu Val Cys
            340                 345                 350
 
cca act gtt gct tta gat caa cct aaa ata gaa gtt cat tct ttg tct   1104
Pro Thr Val Ala Leu Asp Gln Pro Lys Ile Glu Val His Ser Leu Ser
        355                 360                 365
 
att ggt ggt aaa gaa gat cca gct aga ttg gtt ttt aat gga ata tct   1152
Ile Gly Gly Lys Glu Asp Pro Ala Arg Leu Val Phe Asn Gly Ile Ser
    370                 375                 380
 
ggt tct gct att cag gca tct att gtt gat ata ggt ggt aga ttt aga   1200
Gly Ser Ala Ile Gln Ala Ser Ile Val Asp Ile Gly Gly Arg Phe Arg
385                 390                 395                 400
 
ttg gtt cta aac gaa gtt aat ggt caa gaa att gaa aaa gat atg cca   1248
Leu Val Leu Asn Glu Val Asn Gly Gln Glu Ile Glu Lys Asp Met Pro
                405                 410                 415
 
aat tta cca gtc gct aga gtt ttg tgg aaa cca gaa cca tct tta aaa   1296
Asn Leu Pro Val Ala Arg Val Leu Trp Lys Pro Glu Pro Ser Leu Lys
            420                 425                 430
 
act gcc gca gag gcc tgg att ttg gcc gga ggt gca cac cat act tgt   1344
Thr Ala Ala Glu Ala Trp Ile Leu Ala Gly Gly Ala His His Thr Cys
        435                 440                 445
 
ttg tct tat gaa ttg act gca gag caa atg ttg gat tgg gct gaa atg   1392
Leu Ser Tyr Glu Leu Thr Ala Glu Gln Met Leu Asp Trp Ala Glu Met
    450                 455                 460
 
gca gga atc gaa tct gtt ttg att tca agg gat act act att cat aaa   1440
Ala Gly Ile Glu Ser Val Leu Ile Ser Arg Asp Thr Thr Ile His Lys
465                 470                 475                 480
 
tta aag cat gaa tta aaa tgg aat gaa gca ttg tat aga ttg caa aaa   1488
Leu Lys His Glu Leu Lys Trp Asn Glu Ala Leu Tyr Arg Leu Gln Lys
                485                 490                 495
 


<210> 292
<211> 496
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in S. cerevisiae

<400> 292
Met Leu Gln Thr Lys Asp Tyr Glu Phe Trp Phe Val Thr Gly Ser Gln
 1               5                  10                  15      
His Leu Tyr Gly Glu Glu Thr Leu Glu Leu Val Asp Gln His Ala Lys
            20                  25                  30          
Ser Ile Cys Glu Gly Leu Ser Gly Ile Ser Ser Arg Tyr Lys Ile Thr
        35                  40                  45              
His Lys Pro Val Val Thr Ser Pro Glu Thr Ile Arg Glu Leu Leu Arg
    50                  55                  60                  
Glu Ala Glu Tyr Ser Glu Thr Cys Ala Gly Ile Ile Thr Trp Met His
65                  70                  75                  80  
Thr Phe Ser Pro Ala Lys Met Trp Ile Glu Gly Leu Ser Ser Tyr Gln
                85                  90                  95      
Lys Pro Leu Met His Leu His Thr Gln Tyr Asn Arg Asp Ile Pro Trp
            100                 105                 110         
Gly Thr Ile Asp Met Asp Phe Met Asn Ser Asn Gln Ser Ala His Gly
        115                 120                 125             
Asp Arg Glu Tyr Gly Tyr Ile Asn Ser Arg Met Gly Leu Ser Arg Lys
    130                 135                 140                 
Val Ile Ala Gly Tyr Trp Asp Asp Glu Glu Val Lys Lys Glu Met Ser
145                 150                 155                 160 
Gln Trp Met Asp Thr Ala Ala Ala Leu Asn Glu Ser Arg His Ile Lys
                165                 170                 175     
Val Ala Arg Phe Gly Asp Asn Met Arg His Val Ala Val Thr Asp Gly
            180                 185                 190         
Asp Lys Val Gly Ala His Ile Gln Phe Gly Trp Gln Val Asp Gly Tyr
        195                 200                 205             
Gly Ile Gly Asp Leu Val Glu Val Met Asp Arg Ile Thr Asp Asp Glu
    210                 215                 220                 
Val Asp Thr Leu Tyr Ala Glu Tyr Asp Arg Leu Tyr Val Ile Ser Glu
225                 230                 235                 240 
Glu Thr Lys Arg Asp Glu Ala Lys Val Ala Ser Ile Lys Glu Gln Ala
                245                 250                 255     
Lys Ile Glu Leu Gly Leu Thr Ala Phe Leu Glu Gln Gly Gly Tyr Thr
            260                 265                 270         
Ala Phe Thr Thr Ser Phe Glu Val Leu His Gly Met Lys Gln Leu Pro
        275                 280                 285             
Gly Leu Ala Val Gln Arg Leu Met Glu Lys Gly Tyr Gly Phe Ala Gly
    290                 295                 300                 
Glu Gly Asp Trp Lys Thr Ala Ala Leu Val Arg Met Met Lys Ile Met
305                 310                 315                 320 
Ala Lys Gly Lys Arg Thr Ser Phe Met Glu Asp Tyr Thr Tyr His Phe
                325                 330                 335     
Glu Pro Gly Asn Glu Met Ile Leu Gly Ser His Met Leu Glu Val Cys
            340                 345                 350         
Pro Thr Val Ala Leu Asp Gln Pro Lys Ile Glu Val His Ser Leu Ser
        355                 360                 365             
Ile Gly Gly Lys Glu Asp Pro Ala Arg Leu Val Phe Asn Gly Ile Ser
    370                 375                 380                 
Gly Ser Ala Ile Gln Ala Ser Ile Val Asp Ile Gly Gly Arg Phe Arg
385                 390                 395                 400 
Leu Val Leu Asn Glu Val Asn Gly Gln Glu Ile Glu Lys Asp Met Pro
                405                 410                 415     
Asn Leu Pro Val Ala Arg Val Leu Trp Lys Pro Glu Pro Ser Leu Lys
            420                 425                 430         
Thr Ala Ala Glu Ala Trp Ile Leu Ala Gly Gly Ala His His Thr Cys
        435                 440                 445             
Leu Ser Tyr Glu Leu Thr Ala Glu Gln Met Leu Asp Trp Ala Glu Met
    450                 455                 460                 
Ala Gly Ile Glu Ser Val Leu Ile Ser Arg Asp Thr Thr Ile His Lys
465                 470                 475                 480 
Leu Lys His Glu Leu Lys Trp Asn Glu Ala Leu Tyr Arg Leu Gln Lys
                485                 490                 495     


<210> 293
<211> 1488
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in E. coli

<220> 
<221> CDS            
<222> (1)...(1488)

<400> 293
atg ctg cag acc aaa gac tac gaa ttt tgg ttc gtt acc ggt tct cag   48
Met Leu Gln Thr Lys Asp Tyr Glu Phe Trp Phe Val Thr Gly Ser Gln
 1               5                   10                  15
 
cac ctg tac ggt gaa gaa acc ctc gaa ctg gtt gac cag cac gcg aaa   96
His Leu Tyr Gly Glu Glu Thr Leu Glu Leu Val Asp Gln His Ala Lys
             20                  25                  30
 
tct atc tgc gaa ggt ctg tct ggt atc tct tct cgt tac aaa atc acc   144
Ser Ile Cys Glu Gly Leu Ser Gly Ile Ser Ser Arg Tyr Lys Ile Thr
         35                  40                  45
 
cac aaa ccg gtt gtt acc tct ccg gaa acc atc cgt gaa ctc ctg cgt   192
His Lys Pro Val Val Thr Ser Pro Glu Thr Ile Arg Glu Leu Leu Arg
     50                  55                  60
 
gaa gca gaa tac tct gaa acc tgt gct ggc atc atc act tgg atg cac   240
Glu Ala Glu Tyr Ser Glu Thr Cys Ala Gly Ile Ile Thr Trp Met His
 65                  70                  75                  80
 
acc ttc tct ccg gcg aaa atg tgg atc gaa ggc ctg agc tct tac cag   288
Thr Phe Ser Pro Ala Lys Met Trp Ile Glu Gly Leu Ser Ser Tyr Gln
                 85                  90                  95
 
aaa ccg ctg atg cac ctg cac acc cag tac aac cgt gac atc ccg tgg   336
Lys Pro Leu Met His Leu His Thr Gln Tyr Asn Arg Asp Ile Pro Trp
            100                 105                 110
 
ggt act att gac atg gac ttc atg aac tct aac cag tct gcg cac ggt   384
Gly Thr Ile Asp Met Asp Phe Met Asn Ser Asn Gln Ser Ala His Gly
        115                 120                 125
 
gac cgc gaa tac ggt tac atc aac tct cgt atg ggt ctg tct cgt aaa   432
Asp Arg Glu Tyr Gly Tyr Ile Asn Ser Arg Met Gly Leu Ser Arg Lys
    130                 135                 140
 
gtt atc gcg ggt tat tgg gac gac gaa gaa gtt aaa aag gaa atg tct   480
Val Ile Ala Gly Tyr Trp Asp Asp Glu Glu Val Lys Lys Glu Met Ser
145                 150                 155                 160
 
cag tgg atg gac act gca gcg gct ctg aac gaa tct cgt cac atc aaa   528
Gln Trp Met Asp Thr Ala Ala Ala Leu Asn Glu Ser Arg His Ile Lys
                165                 170                 175
 
gtt gca cgc ttc ggt gac aac atg cgt cac gtt gcg gtt acg gac ggc   576
Val Ala Arg Phe Gly Asp Asn Met Arg His Val Ala Val Thr Asp Gly
            180                 185                 190
 
gac aaa gtt ggt gcg cat atc cag ttc ggt tgg cag gtt gac ggt tat   624
Asp Lys Val Gly Ala His Ile Gln Phe Gly Trp Gln Val Asp Gly Tyr
        195                 200                 205
 
ggt atc ggt gat ttg gtt gaa gtt atg gac cgt atc acc gac gac gag   672
Gly Ile Gly Asp Leu Val Glu Val Met Asp Arg Ile Thr Asp Asp Glu
    210                 215                 220
 
gtt gac acc ctg tac gcg gaa tac gac cgt ctg tac gtt atc tct gaa   720
Val Asp Thr Leu Tyr Ala Glu Tyr Asp Arg Leu Tyr Val Ile Ser Glu
225                 230                 235                 240
 
gaa acc aaa cgt gat gaa gct aaa gtt gcg tct atc aag gaa cag gct   768
Glu Thr Lys Arg Asp Glu Ala Lys Val Ala Ser Ile Lys Glu Gln Ala
                245                 250                 255
 
aaa atc gaa ctg ggt ctg acc gcc ttc ctg gag cag ggt ggt tac acg   816
Lys Ile Glu Leu Gly Leu Thr Ala Phe Leu Glu Gln Gly Gly Tyr Thr
            260                 265                 270
 
gca ttc acc acc tct ttc gaa gtt ctg cac ggt atg aaa cag ctg ccg   864
Ala Phe Thr Thr Ser Phe Glu Val Leu His Gly Met Lys Gln Leu Pro
        275                 280                 285
 
ggt ctc gca gtt cag cgt ctg atg gaa aaa ggt tac ggt ttc gct ggt   912
Gly Leu Ala Val Gln Arg Leu Met Glu Lys Gly Tyr Gly Phe Ala Gly
    290                 295                 300
 
gaa ggt gat tgg aaa act gct gcg ctt gtt cgt atg atg aaa atc atg   960
Glu Gly Asp Trp Lys Thr Ala Ala Leu Val Arg Met Met Lys Ile Met
305                 310                 315                 320
 
gct aaa ggt aaa cgt acc tct ttc atg gaa gac tac acc tac cac ttc   1008
Ala Lys Gly Lys Arg Thr Ser Phe Met Glu Asp Tyr Thr Tyr His Phe
                325                 330                 335
 
gaa ccg ggt aac gaa atg atc ctg ggt tct cac atg ctg gag gtt tgc   1056
Glu Pro Gly Asn Glu Met Ile Leu Gly Ser His Met Leu Glu Val Cys
            340                 345                 350
 
ccg acc gtt gct ctg gac cag ccg aaa atc gaa gtt cac tct ctg tct   1104
Pro Thr Val Ala Leu Asp Gln Pro Lys Ile Glu Val His Ser Leu Ser
        355                 360                 365
 
atc ggt ggt aag gag gat ccg gcc cgc ctg gtt ttc aac ggt atc tct   1152
Ile Gly Gly Lys Glu Asp Pro Ala Arg Leu Val Phe Asn Gly Ile Ser
    370                 375                 380
 
ggt tct gcg atc cag gct tct atc gtt gac atc ggt ggc cgt ttt cgt   1200
Gly Ser Ala Ile Gln Ala Ser Ile Val Asp Ile Gly Gly Arg Phe Arg
385                 390                 395                 400
 
ctc gtt ctg aac gaa gtt aac ggt cag gaa atc gaa aaa gac atg ccg   1248
Leu Val Leu Asn Glu Val Asn Gly Gln Glu Ile Glu Lys Asp Met Pro
                405                 410                 415
 
aac ttg ccg gtt gcg cgt gtt ctg tgg aaa ccg gag cca agc ctc aaa   1296
Asn Leu Pro Val Ala Arg Val Leu Trp Lys Pro Glu Pro Ser Leu Lys
            420                 425                 430
 
act gcg gct gag gcg tgg att ttg gct ggc ggc gct cat cat acc tgc   1344
Thr Ala Ala Glu Ala Trp Ile Leu Ala Gly Gly Ala His His Thr Cys
        435                 440                 445
 
ctg tct tac gaa ctg act gca gaa cag atg ctg gat tgg gcg gaa atg   1392
Leu Ser Tyr Glu Leu Thr Ala Glu Gln Met Leu Asp Trp Ala Glu Met
    450                 455                 460
 
gct ggt att gag tct gtt ctg atc tct cgt gac acc acc att cac aaa   1440
Ala Gly Ile Glu Ser Val Leu Ile Ser Arg Asp Thr Thr Ile His Lys
465                 470                 475                 480
 
ctg aaa cac gaa ctg aaa tgg aac gaa gct ctg tac cgt ctg cag aaa   1488
Leu Lys His Glu Leu Lys Trp Asn Glu Ala Leu Tyr Arg Leu Gln Lys
                485                 490                 495
 


<210> 294
<211> 496
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in E. coli

<400> 294
Met Leu Gln Thr Lys Asp Tyr Glu Phe Trp Phe Val Thr Gly Ser Gln
 1               5                  10                  15      
His Leu Tyr Gly Glu Glu Thr Leu Glu Leu Val Asp Gln His Ala Lys
            20                  25                  30          
Ser Ile Cys Glu Gly Leu Ser Gly Ile Ser Ser Arg Tyr Lys Ile Thr
        35                  40                  45              
His Lys Pro Val Val Thr Ser Pro Glu Thr Ile Arg Glu Leu Leu Arg
    50                  55                  60                  
Glu Ala Glu Tyr Ser Glu Thr Cys Ala Gly Ile Ile Thr Trp Met His
65                  70                  75                  80  
Thr Phe Ser Pro Ala Lys Met Trp Ile Glu Gly Leu Ser Ser Tyr Gln
                85                  90                  95      
Lys Pro Leu Met His Leu His Thr Gln Tyr Asn Arg Asp Ile Pro Trp
            100                 105                 110         
Gly Thr Ile Asp Met Asp Phe Met Asn Ser Asn Gln Ser Ala His Gly
        115                 120                 125             
Asp Arg Glu Tyr Gly Tyr Ile Asn Ser Arg Met Gly Leu Ser Arg Lys
    130                 135                 140                 
Val Ile Ala Gly Tyr Trp Asp Asp Glu Glu Val Lys Lys Glu Met Ser
145                 150                 155                 160 
Gln Trp Met Asp Thr Ala Ala Ala Leu Asn Glu Ser Arg His Ile Lys
                165                 170                 175     
Val Ala Arg Phe Gly Asp Asn Met Arg His Val Ala Val Thr Asp Gly
            180                 185                 190         
Asp Lys Val Gly Ala His Ile Gln Phe Gly Trp Gln Val Asp Gly Tyr
        195                 200                 205             
Gly Ile Gly Asp Leu Val Glu Val Met Asp Arg Ile Thr Asp Asp Glu
    210                 215                 220                 
Val Asp Thr Leu Tyr Ala Glu Tyr Asp Arg Leu Tyr Val Ile Ser Glu
225                 230                 235                 240 
Glu Thr Lys Arg Asp Glu Ala Lys Val Ala Ser Ile Lys Glu Gln Ala
                245                 250                 255     
Lys Ile Glu Leu Gly Leu Thr Ala Phe Leu Glu Gln Gly Gly Tyr Thr
            260                 265                 270         
Ala Phe Thr Thr Ser Phe Glu Val Leu His Gly Met Lys Gln Leu Pro
        275                 280                 285             
Gly Leu Ala Val Gln Arg Leu Met Glu Lys Gly Tyr Gly Phe Ala Gly
    290                 295                 300                 
Glu Gly Asp Trp Lys Thr Ala Ala Leu Val Arg Met Met Lys Ile Met
305                 310                 315                 320 
Ala Lys Gly Lys Arg Thr Ser Phe Met Glu Asp Tyr Thr Tyr His Phe
                325                 330                 335     
Glu Pro Gly Asn Glu Met Ile Leu Gly Ser His Met Leu Glu Val Cys
            340                 345                 350         
Pro Thr Val Ala Leu Asp Gln Pro Lys Ile Glu Val His Ser Leu Ser
        355                 360                 365             
Ile Gly Gly Lys Glu Asp Pro Ala Arg Leu Val Phe Asn Gly Ile Ser
    370                 375                 380                 
Gly Ser Ala Ile Gln Ala Ser Ile Val Asp Ile Gly Gly Arg Phe Arg
385                 390                 395                 400 
Leu Val Leu Asn Glu Val Asn Gly Gln Glu Ile Glu Lys Asp Met Pro
                405                 410                 415     
Asn Leu Pro Val Ala Arg Val Leu Trp Lys Pro Glu Pro Ser Leu Lys
            420                 425                 430         
Thr Ala Ala Glu Ala Trp Ile Leu Ala Gly Gly Ala His His Thr Cys
        435                 440                 445             
Leu Ser Tyr Glu Leu Thr Ala Glu Gln Met Leu Asp Trp Ala Glu Met
    450                 455                 460                 
Ala Gly Ile Glu Ser Val Leu Ile Ser Arg Asp Thr Thr Ile His Lys
465                 470                 475                 480 
Leu Lys His Glu Leu Lys Trp Asn Glu Ala Leu Tyr Arg Leu Gln Lys
                485                 490                 495     


<210> 295
<211> 1488
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in P. pastoris

<220> 
<221> CDS            
<222> (1)...(1488)

<400> 295
atg ttg caa act aaa gat tat gaa ttt tgg ttt gtt act gga tct caa   48
Met Leu Gln Thr Lys Asp Tyr Glu Phe Trp Phe Val Thr Gly Ser Gln
 1               5                   10                  15
 
cat ttg tat gga gaa gaa aca tta gag ttg gtt gat cag cac gct aaa   96
His Leu Tyr Gly Glu Glu Thr Leu Glu Leu Val Asp Gln His Ala Lys
             20                  25                  30
 
tct att tgt gaa gga ttg tct gga att tct tct agg tat aaa att act   144
Ser Ile Cys Glu Gly Leu Ser Gly Ile Ser Ser Arg Tyr Lys Ile Thr
         35                  40                  45
 
cat aag cca gtt gtt act tct cca gaa act att aga gaa ttg ttg aga   192
His Lys Pro Val Val Thr Ser Pro Glu Thr Ile Arg Glu Leu Leu Arg
     50                  55                  60
 
gaa gct gaa tat tct gaa act tgt gct gga att att act tgg atg cat   240
Glu Ala Glu Tyr Ser Glu Thr Cys Ala Gly Ile Ile Thr Trp Met His
 65                  70                  75                  80
 
act ttt tct cca gct aaa atg tgg att gaa gga tta tct tct tat caa   288
Thr Phe Ser Pro Ala Lys Met Trp Ile Glu Gly Leu Ser Ser Tyr Gln
                 85                  90                  95
 
aaa cct ttg atg cat ttg cat act caa tat aat aga gac att cca tgg   336
Lys Pro Leu Met His Leu His Thr Gln Tyr Asn Arg Asp Ile Pro Trp
            100                 105                 110
 
ggt act att gat atg gat ttt atg aat agt aat caa tct gct cat gga   384
Gly Thr Ile Asp Met Asp Phe Met Asn Ser Asn Gln Ser Ala His Gly
        115                 120                 125
 
gat aga gaa tat gga tat att aat tct agg atg gga ttg tct agg aaa   432
Asp Arg Glu Tyr Gly Tyr Ile Asn Ser Arg Met Gly Leu Ser Arg Lys
    130                 135                 140
 
gtt att gct gga tat tgg gat gat gaa gaa gtt aaa aag gaa atg tct   480
Val Ile Ala Gly Tyr Trp Asp Asp Glu Glu Val Lys Lys Glu Met Ser
145                 150                 155                 160
 
caa tgg atg gat aca gct gct gca tta aat gaa tct agg cat att aaa   528
Gln Trp Met Asp Thr Ala Ala Ala Leu Asn Glu Ser Arg His Ile Lys
                165                 170                 175
 
gtt gct aga ttc gga gat aat atg aga cat gtt gct gtt act gat gga   576
Val Ala Arg Phe Gly Asp Asn Met Arg His Val Ala Val Thr Asp Gly
            180                 185                 190
 
gat aaa gtt gga gct cat att caa ttc gga tgg caa gtt gat gga tat   624
Asp Lys Val Gly Ala His Ile Gln Phe Gly Trp Gln Val Asp Gly Tyr
        195                 200                 205
 
gga att gga gat ttg gtt gaa gtt atg gat aga att act gat gat gag   672
Gly Ile Gly Asp Leu Val Glu Val Met Asp Arg Ile Thr Asp Asp Glu
    210                 215                 220
 
gtt gat act tta tat gct gaa tat gat aga ttg tat gtt att tct gaa   720
Val Asp Thr Leu Tyr Ala Glu Tyr Asp Arg Leu Tyr Val Ile Ser Glu
225                 230                 235                 240
 
gaa act aaa aga gat gaa gct aaa gtt gct tct att aaa gaa caa gct   768
Glu Thr Lys Arg Asp Glu Ala Lys Val Ala Ser Ile Lys Glu Gln Ala
                245                 250                 255
 
aaa att gaa ttg gga tta act gct ttt ctt gag caa gga gga tat act   816
Lys Ile Glu Leu Gly Leu Thr Ala Phe Leu Glu Gln Gly Gly Tyr Thr
            260                 265                 270
 
gct ttt act act tct ttt gag gtt ttg cat ggt atg aaa caa ttg cca   864
Ala Phe Thr Thr Ser Phe Glu Val Leu His Gly Met Lys Gln Leu Pro
        275                 280                 285
 
gga ttg gct gtt caa aga ttg atg gaa aaa gga tat gga ttc gct gga   912
Gly Leu Ala Val Gln Arg Leu Met Glu Lys Gly Tyr Gly Phe Ala Gly
    290                 295                 300
 
gag gga gat tgg aaa act gca gcc ctc gtt aga atg atg aaa att atg   960
Glu Gly Asp Trp Lys Thr Ala Ala Leu Val Arg Met Met Lys Ile Met
305                 310                 315                 320
 
gct aaa gga aaa aga act tct ttt atg gaa gat tat act tat cat ttc   1008
Ala Lys Gly Lys Arg Thr Ser Phe Met Glu Asp Tyr Thr Tyr His Phe
                325                 330                 335
 
gaa cca gga aat gaa atg att ttg gga tct cac atg tta gag gtt tgt   1056
Glu Pro Gly Asn Glu Met Ile Leu Gly Ser His Met Leu Glu Val Cys
            340                 345                 350
 
cca act gtt gct ttg gat caa cct aaa ata gaa gtt cat tca ttg tct   1104
Pro Thr Val Ala Leu Asp Gln Pro Lys Ile Glu Val His Ser Leu Ser
        355                 360                 365
 
att gga gga aaa gaa gat cca gct aga ttg gtt ttt aat gga att tca   1152
Ile Gly Gly Lys Glu Asp Pro Ala Arg Leu Val Phe Asn Gly Ile Ser
    370                 375                 380
 
gga tct gct att cag gct tct att gtt gat ata gga ggt aga ttt aga   1200
Gly Ser Ala Ile Gln Ala Ser Ile Val Asp Ile Gly Gly Arg Phe Arg
385                 390                 395                 400
 
ttg gtt cta aac gaa gtt aat gga caa gaa att gaa aaa gat atg cca   1248
Leu Val Leu Asn Glu Val Asn Gly Gln Glu Ile Glu Lys Asp Met Pro
                405                 410                 415
 
aat ttg cct gtt gct aga gtt ttg tgg aag ccc gaa cca tct tta aaa   1296
Asn Leu Pro Val Ala Arg Val Leu Trp Lys Pro Glu Pro Ser Leu Lys
            420                 425                 430
 
aca gcc gca gaa gca tgg att ttg gca ggc gga gca cac cat act tgt   1344
Thr Ala Ala Glu Ala Trp Ile Leu Ala Gly Gly Ala His His Thr Cys
        435                 440                 445
 
ttg tct tat gaa ttg acc gcc gaa caa atg ttg gat tgg gca gaa atg   1392
Leu Ser Tyr Glu Leu Thr Ala Glu Gln Met Leu Asp Trp Ala Glu Met
    450                 455                 460
 
gct ggg atc gaa tct gtt ttg att tcg aga gat act act att cat aaa   1440
Ala Gly Ile Glu Ser Val Leu Ile Ser Arg Asp Thr Thr Ile His Lys
465                 470                 475                 480
 
ttg aag cat gaa ttg aag tgg aat gaa gca ttg tat aga ttg caa aaa   1488
Leu Lys His Glu Leu Lys Trp Asn Glu Ala Leu Tyr Arg Leu Gln Lys
                485                 490                 495
 


<210> 296
<211> 496
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in P. pastoris

<400> 296
Met Leu Gln Thr Lys Asp Tyr Glu Phe Trp Phe Val Thr Gly Ser Gln
 1               5                  10                  15      
His Leu Tyr Gly Glu Glu Thr Leu Glu Leu Val Asp Gln His Ala Lys
            20                  25                  30          
Ser Ile Cys Glu Gly Leu Ser Gly Ile Ser Ser Arg Tyr Lys Ile Thr
        35                  40                  45              
His Lys Pro Val Val Thr Ser Pro Glu Thr Ile Arg Glu Leu Leu Arg
    50                  55                  60                  
Glu Ala Glu Tyr Ser Glu Thr Cys Ala Gly Ile Ile Thr Trp Met His
65                  70                  75                  80  
Thr Phe Ser Pro Ala Lys Met Trp Ile Glu Gly Leu Ser Ser Tyr Gln
                85                  90                  95      
Lys Pro Leu Met His Leu His Thr Gln Tyr Asn Arg Asp Ile Pro Trp
            100                 105                 110         
Gly Thr Ile Asp Met Asp Phe Met Asn Ser Asn Gln Ser Ala His Gly
        115                 120                 125             
Asp Arg Glu Tyr Gly Tyr Ile Asn Ser Arg Met Gly Leu Ser Arg Lys
    130                 135                 140                 
Val Ile Ala Gly Tyr Trp Asp Asp Glu Glu Val Lys Lys Glu Met Ser
145                 150                 155                 160 
Gln Trp Met Asp Thr Ala Ala Ala Leu Asn Glu Ser Arg His Ile Lys
                165                 170                 175     
Val Ala Arg Phe Gly Asp Asn Met Arg His Val Ala Val Thr Asp Gly
            180                 185                 190         
Asp Lys Val Gly Ala His Ile Gln Phe Gly Trp Gln Val Asp Gly Tyr
        195                 200                 205             
Gly Ile Gly Asp Leu Val Glu Val Met Asp Arg Ile Thr Asp Asp Glu
    210                 215                 220                 
Val Asp Thr Leu Tyr Ala Glu Tyr Asp Arg Leu Tyr Val Ile Ser Glu
225                 230                 235                 240 
Glu Thr Lys Arg Asp Glu Ala Lys Val Ala Ser Ile Lys Glu Gln Ala
                245                 250                 255     
Lys Ile Glu Leu Gly Leu Thr Ala Phe Leu Glu Gln Gly Gly Tyr Thr
            260                 265                 270         
Ala Phe Thr Thr Ser Phe Glu Val Leu His Gly Met Lys Gln Leu Pro
        275                 280                 285             
Gly Leu Ala Val Gln Arg Leu Met Glu Lys Gly Tyr Gly Phe Ala Gly
    290                 295                 300                 
Glu Gly Asp Trp Lys Thr Ala Ala Leu Val Arg Met Met Lys Ile Met
305                 310                 315                 320 
Ala Lys Gly Lys Arg Thr Ser Phe Met Glu Asp Tyr Thr Tyr His Phe
                325                 330                 335     
Glu Pro Gly Asn Glu Met Ile Leu Gly Ser His Met Leu Glu Val Cys
            340                 345                 350         
Pro Thr Val Ala Leu Asp Gln Pro Lys Ile Glu Val His Ser Leu Ser
        355                 360                 365             
Ile Gly Gly Lys Glu Asp Pro Ala Arg Leu Val Phe Asn Gly Ile Ser
    370                 375                 380                 
Gly Ser Ala Ile Gln Ala Ser Ile Val Asp Ile Gly Gly Arg Phe Arg
385                 390                 395                 400 
Leu Val Leu Asn Glu Val Asn Gly Gln Glu Ile Glu Lys Asp Met Pro
                405                 410                 415     
Asn Leu Pro Val Ala Arg Val Leu Trp Lys Pro Glu Pro Ser Leu Lys
            420                 425                 430         
Thr Ala Ala Glu Ala Trp Ile Leu Ala Gly Gly Ala His His Thr Cys
        435                 440                 445             
Leu Ser Tyr Glu Leu Thr Ala Glu Gln Met Leu Asp Trp Ala Glu Met
    450                 455                 460                 
Ala Gly Ile Glu Ser Val Leu Ile Ser Arg Asp Thr Thr Ile His Lys
465                 470                 475                 480 
Leu Lys His Glu Leu Lys Trp Asn Glu Ala Leu Tyr Arg Leu Gln Lys
                485                 490                 495     


<210> 297
<211> 1488
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in K. lactis

<220> 
<221> CDS            
<222> (1)...(1488)

<400> 297
atg ttg caa act aaa gat tat gaa ttt tgg ttc gtt act ggt tct caa   48
Met Leu Gln Thr Lys Asp Tyr Glu Phe Trp Phe Val Thr Gly Ser Gln
 1               5                   10                  15
 
cat ttg tat ggt gaa gaa act tta gaa ttg gtt gat cag cat gcg aaa   96
His Leu Tyr Gly Glu Glu Thr Leu Glu Leu Val Asp Gln His Ala Lys
             20                  25                  30
 
tct att tgt gaa ggt ttg tct ggt ata tct tct agg tat aaa att act   144
Ser Ile Cys Glu Gly Leu Ser Gly Ile Ser Ser Arg Tyr Lys Ile Thr
         35                  40                  45
 
cat aaa cca gtt gtt act tct cct gaa act att aga gaa ttg ttg aga   192
His Lys Pro Val Val Thr Ser Pro Glu Thr Ile Arg Glu Leu Leu Arg
     50                  55                  60
 
gaa gct gaa tat tct gaa act tgt gct gga atc att act tgg atg cat   240
Glu Ala Glu Tyr Ser Glu Thr Cys Ala Gly Ile Ile Thr Trp Met His
 65                  70                  75                  80
 
act ttc tct cct gct aaa atg tgg att gaa gga ttg tcc tct tat caa   288
Thr Phe Ser Pro Ala Lys Met Trp Ile Glu Gly Leu Ser Ser Tyr Gln
                 85                  90                  95
 
aaa cca ttg atg cat ttg cat act caa tat aat aga gac att cca tgg   336
Lys Pro Leu Met His Leu His Thr Gln Tyr Asn Arg Asp Ile Pro Trp
            100                 105                 110
 
gga act att gat atg gat ttc atg aac tct aat caa tct gct cat ggt   384
Gly Thr Ile Asp Met Asp Phe Met Asn Ser Asn Gln Ser Ala His Gly
        115                 120                 125
 
gat aga gaa tat ggt tat att aat tct agg atg ggt ttg agt aga aaa   432
Asp Arg Glu Tyr Gly Tyr Ile Asn Ser Arg Met Gly Leu Ser Arg Lys
    130                 135                 140
 
gtt att gct ggt tat tgg gat gat gaa gaa gtt aaa aag gaa atg tct   480
Val Ile Ala Gly Tyr Trp Asp Asp Glu Glu Val Lys Lys Glu Met Ser
145                 150                 155                 160
 
caa tgg atg gat aca gct gcc gca tta aat gaa tct agg cat att aaa   528
Gln Trp Met Asp Thr Ala Ala Ala Leu Asn Glu Ser Arg His Ile Lys
                165                 170                 175
 
gtt gct aga ttc ggt gat aat atg aga cat gtt gct gtt act gat ggt   576
Val Ala Arg Phe Gly Asp Asn Met Arg His Val Ala Val Thr Asp Gly
            180                 185                 190
 
gat aag gtt ggt gct cat atc caa ttc ggt tgg caa gtt gat ggt tat   624
Asp Lys Val Gly Ala His Ile Gln Phe Gly Trp Gln Val Asp Gly Tyr
        195                 200                 205
 
gga atc ggt gac ttg gtt gaa gtt atg gat aga att act gat gat gag   672
Gly Ile Gly Asp Leu Val Glu Val Met Asp Arg Ile Thr Asp Asp Glu
    210                 215                 220
 
gtt gat aca ttg tat gct gaa tat gat aga ttg tat gtt att tct gaa   720
Val Asp Thr Leu Tyr Ala Glu Tyr Asp Arg Leu Tyr Val Ile Ser Glu
225                 230                 235                 240
 
gaa act aaa aga gat gaa gct aaa gtt gcc tct att aaa gaa caa gct   768
Glu Thr Lys Arg Asp Glu Ala Lys Val Ala Ser Ile Lys Glu Gln Ala
                245                 250                 255
 
aaa att gaa ttg ggt cta act gct ttc ttg gaa caa ggt ggt tat act   816
Lys Ile Glu Leu Gly Leu Thr Ala Phe Leu Glu Gln Gly Gly Tyr Thr
            260                 265                 270
 
gct ttc act act tct ttc gag gtt ttg cat ggt atg aaa caa ttg cca   864
Ala Phe Thr Thr Ser Phe Glu Val Leu His Gly Met Lys Gln Leu Pro
        275                 280                 285
 
ggt ttg gct gtt caa aga ttg atg gaa aaa ggt tat ggt ttc gca ggt   912
Gly Leu Ala Val Gln Arg Leu Met Glu Lys Gly Tyr Gly Phe Ala Gly
    290                 295                 300
 
gaa ggg gat tgg aaa act gca gca ttg gtt aga atg atg aaa att atg   960
Glu Gly Asp Trp Lys Thr Ala Ala Leu Val Arg Met Met Lys Ile Met
305                 310                 315                 320
 
gct aaa ggt aag aga act tct ttc atg gaa gat tat act tat cac ttc   1008
Ala Lys Gly Lys Arg Thr Ser Phe Met Glu Asp Tyr Thr Tyr His Phe
                325                 330                 335
 
gaa cct ggt aat gaa atg att ttg ggt tct cac atg ttg gaa gtt tgt   1056
Glu Pro Gly Asn Glu Met Ile Leu Gly Ser His Met Leu Glu Val Cys
            340                 345                 350
 
cca act gtt gct ttg gat caa cct aaa atc gaa gtt cat tct tta tct   1104
Pro Thr Val Ala Leu Asp Gln Pro Lys Ile Glu Val His Ser Leu Ser
        355                 360                 365
 
att ggt gga aaa gaa gat cca gct aga ttg gtt ttc aat gga att tct   1152
Ile Gly Gly Lys Glu Asp Pro Ala Arg Leu Val Phe Asn Gly Ile Ser
    370                 375                 380
 
ggt tct gct att cag gca tct att gtt gac att gga ggt aga ttc aga   1200
Gly Ser Ala Ile Gln Ala Ser Ile Val Asp Ile Gly Gly Arg Phe Arg
385                 390                 395                 400
 
ctc gtc tta aat gaa gtt aat ggt caa gaa att gaa aaa gat atg cca   1248
Leu Val Leu Asn Glu Val Asn Gly Gln Glu Ile Glu Lys Asp Met Pro
                405                 410                 415
 
aat ctt cca gtt gct cgt gtt ttg tgg aaa cca gag cca tct tta aag   1296
Asn Leu Pro Val Ala Arg Val Leu Trp Lys Pro Glu Pro Ser Leu Lys
            420                 425                 430
 
acc gca gcc gag gca tgg att ttg gcc gga gga gcc cat cat act tgt   1344
Thr Ala Ala Glu Ala Trp Ile Leu Ala Gly Gly Ala His His Thr Cys
        435                 440                 445
 
ttg tct tat gaa ttg act gca gaa caa atg ttg gat tgg gct gaa atg   1392
Leu Ser Tyr Glu Leu Thr Ala Glu Gln Met Leu Asp Trp Ala Glu Met
    450                 455                 460
 
gcg gga att gaa tct gtt ttg att tca cgt gat act act att cat aaa   1440
Ala Gly Ile Glu Ser Val Leu Ile Ser Arg Asp Thr Thr Ile His Lys
465                 470                 475                 480
 
tta aaa cat gaa tta aag tgg aat gaa gca cta tat aga ttg caa aaa   1488
Leu Lys His Glu Leu Lys Trp Asn Glu Ala Leu Tyr Arg Leu Gln Lys
                485                 490                 495
 


<210> 298
<211> 496
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in K. lactis

<400> 298
Met Leu Gln Thr Lys Asp Tyr Glu Phe Trp Phe Val Thr Gly Ser Gln
 1               5                  10                  15      
His Leu Tyr Gly Glu Glu Thr Leu Glu Leu Val Asp Gln His Ala Lys
            20                  25                  30          
Ser Ile Cys Glu Gly Leu Ser Gly Ile Ser Ser Arg Tyr Lys Ile Thr
        35                  40                  45              
His Lys Pro Val Val Thr Ser Pro Glu Thr Ile Arg Glu Leu Leu Arg
    50                  55                  60                  
Glu Ala Glu Tyr Ser Glu Thr Cys Ala Gly Ile Ile Thr Trp Met His
65                  70                  75                  80  
Thr Phe Ser Pro Ala Lys Met Trp Ile Glu Gly Leu Ser Ser Tyr Gln
                85                  90                  95      
Lys Pro Leu Met His Leu His Thr Gln Tyr Asn Arg Asp Ile Pro Trp
            100                 105                 110         
Gly Thr Ile Asp Met Asp Phe Met Asn Ser Asn Gln Ser Ala His Gly
        115                 120                 125             
Asp Arg Glu Tyr Gly Tyr Ile Asn Ser Arg Met Gly Leu Ser Arg Lys
    130                 135                 140                 
Val Ile Ala Gly Tyr Trp Asp Asp Glu Glu Val Lys Lys Glu Met Ser
145                 150                 155                 160 
Gln Trp Met Asp Thr Ala Ala Ala Leu Asn Glu Ser Arg His Ile Lys
                165                 170                 175     
Val Ala Arg Phe Gly Asp Asn Met Arg His Val Ala Val Thr Asp Gly
            180                 185                 190         
Asp Lys Val Gly Ala His Ile Gln Phe Gly Trp Gln Val Asp Gly Tyr
        195                 200                 205             
Gly Ile Gly Asp Leu Val Glu Val Met Asp Arg Ile Thr Asp Asp Glu
    210                 215                 220                 
Val Asp Thr Leu Tyr Ala Glu Tyr Asp Arg Leu Tyr Val Ile Ser Glu
225                 230                 235                 240 
Glu Thr Lys Arg Asp Glu Ala Lys Val Ala Ser Ile Lys Glu Gln Ala
                245                 250                 255     
Lys Ile Glu Leu Gly Leu Thr Ala Phe Leu Glu Gln Gly Gly Tyr Thr
            260                 265                 270         
Ala Phe Thr Thr Ser Phe Glu Val Leu His Gly Met Lys Gln Leu Pro
        275                 280                 285             
Gly Leu Ala Val Gln Arg Leu Met Glu Lys Gly Tyr Gly Phe Ala Gly
    290                 295                 300                 
Glu Gly Asp Trp Lys Thr Ala Ala Leu Val Arg Met Met Lys Ile Met
305                 310                 315                 320 
Ala Lys Gly Lys Arg Thr Ser Phe Met Glu Asp Tyr Thr Tyr His Phe
                325                 330                 335     
Glu Pro Gly Asn Glu Met Ile Leu Gly Ser His Met Leu Glu Val Cys
            340                 345                 350         
Pro Thr Val Ala Leu Asp Gln Pro Lys Ile Glu Val His Ser Leu Ser
        355                 360                 365             
Ile Gly Gly Lys Glu Asp Pro Ala Arg Leu Val Phe Asn Gly Ile Ser
    370                 375                 380                 
Gly Ser Ala Ile Gln Ala Ser Ile Val Asp Ile Gly Gly Arg Phe Arg
385                 390                 395                 400 
Leu Val Leu Asn Glu Val Asn Gly Gln Glu Ile Glu Lys Asp Met Pro
                405                 410                 415     
Asn Leu Pro Val Ala Arg Val Leu Trp Lys Pro Glu Pro Ser Leu Lys
            420                 425                 430         
Thr Ala Ala Glu Ala Trp Ile Leu Ala Gly Gly Ala His His Thr Cys
        435                 440                 445             
Leu Ser Tyr Glu Leu Thr Ala Glu Gln Met Leu Asp Trp Ala Glu Met
    450                 455                 460                 
Ala Gly Ile Glu Ser Val Leu Ile Ser Arg Asp Thr Thr Ile His Lys
465                 470                 475                 480 
Leu Lys His Glu Leu Lys Trp Asn Glu Ala Leu Tyr Arg Leu Gln Lys
                485                 490                 495     


<210> 299
<211> 1488
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in Z. mobilis

<220> 
<221> CDS            
<222> (1)...(1488)

<400> 299
atg ttg cag acc aaa gat tat gaa ttt tgg ttt gtt acc ggt tct cag   48
Met Leu Gln Thr Lys Asp Tyr Glu Phe Trp Phe Val Thr Gly Ser Gln
 1               5                   10                  15
 
cat ttg tat ggt gaa gaa acc ttg gaa ttg gtt gat cag cat gcc aaa   96
His Leu Tyr Gly Glu Glu Thr Leu Glu Leu Val Asp Gln His Ala Lys
             20                  25                  30
 
tct att tgt gaa ggt ttg tct ggc att tct tct cgt tat aaa att acc   144
Ser Ile Cys Glu Gly Leu Ser Gly Ile Ser Ser Arg Tyr Lys Ile Thr
         35                  40                  45
 
cac aaa ccg gtt gtt acc tct ccg gaa acc att cgt gaa ttg ttg cgt   192
His Lys Pro Val Val Thr Ser Pro Glu Thr Ile Arg Glu Leu Leu Arg
     50                  55                  60
 
gaa gct gaa tat tct gaa acc tgt gcc ggg atc att acc tgg atg cat   240
Glu Ala Glu Tyr Ser Glu Thr Cys Ala Gly Ile Ile Thr Trp Met His
 65                  70                  75                  80
 
acc ttt tct ccg gcc aaa atg tgg att gag ggc ttg tct tct tat cag   288
Thr Phe Ser Pro Ala Lys Met Trp Ile Glu Gly Leu Ser Ser Tyr Gln
                 85                  90                  95
 
aaa ccg ctt atg cat ttg cat acc cag tat aat cgt gat atc ccg tgg   336
Lys Pro Leu Met His Leu His Thr Gln Tyr Asn Arg Asp Ile Pro Trp
            100                 105                 110
 
ggt acg att gat atg gat ttt atg aac tct aat cag tct gcc cat ggt   384
Gly Thr Ile Asp Met Asp Phe Met Asn Ser Asn Gln Ser Ala His Gly
        115                 120                 125
 
gat cgt gaa tat ggt tat att aat tct cgt atg ggt ttg tct cgt aaa   432
Asp Arg Glu Tyr Gly Tyr Ile Asn Ser Arg Met Gly Leu Ser Arg Lys
    130                 135                 140
 
gtc att gct ggt tat tgg gat gat gaa gaa gtt aaa aag gaa atg tct   480
Val Ile Ala Gly Tyr Trp Asp Asp Glu Glu Val Lys Lys Glu Met Ser
145                 150                 155                 160
 
cag tgg atg gat acc gcc gca gca ctt aat gaa tct cgt cat att aaa   528
Gln Trp Met Asp Thr Ala Ala Ala Leu Asn Glu Ser Arg His Ile Lys
                165                 170                 175
 
gtt gcc cgc ttt ggt gat aat atg cgt cat gtt gcc gtt acc gat ggt   576
Val Ala Arg Phe Gly Asp Asn Met Arg His Val Ala Val Thr Asp Gly
            180                 185                 190
 
gat aaa gtt ggt gcc cat att cag ttt ggt tgg caa gtt gat ggt tat   624
Asp Lys Val Gly Ala His Ile Gln Phe Gly Trp Gln Val Asp Gly Tyr
        195                 200                 205
 
ggc att ggt gat ttg gtt gaa gtt atg gat cgt att acc gat gat gaa   672
Gly Ile Gly Asp Leu Val Glu Val Met Asp Arg Ile Thr Asp Asp Glu
    210                 215                 220
 
gtt gat acc ttg tat gcc gaa tat gat cgt ttg tat gtt atc tct gaa   720
Val Asp Thr Leu Tyr Ala Glu Tyr Asp Arg Leu Tyr Val Ile Ser Glu
225                 230                 235                 240
 
gaa acc aaa cgt gat gag gcc aaa gtt gct tct att aaa gaa cag gct   768
Glu Thr Lys Arg Asp Glu Ala Lys Val Ala Ser Ile Lys Glu Gln Ala
                245                 250                 255
 
aag att gaa ttg ggt ttg acc gca ttc ttg gaa cag ggt ggt tat acc   816
Lys Ile Glu Leu Gly Leu Thr Ala Phe Leu Glu Gln Gly Gly Tyr Thr
            260                 265                 270
 
gcg ttt acc acc tct ttt gaa gtt ttg cat ggt atg aaa cag ttg cca   864
Ala Phe Thr Thr Ser Phe Glu Val Leu His Gly Met Lys Gln Leu Pro
        275                 280                 285
 
ggt ctt gct gtt cag cgt ctt atg gaa aaa ggt tat ggt ttt gct ggt   912
Gly Leu Ala Val Gln Arg Leu Met Glu Lys Gly Tyr Gly Phe Ala Gly
    290                 295                 300
 
gaa ggt gat tgg aaa acc gct gcc ctt gtt cgt atg atg aaa att atg   960
Glu Gly Asp Trp Lys Thr Ala Ala Leu Val Arg Met Met Lys Ile Met
305                 310                 315                 320
 
gct aag ggt aaa cgt acc tct ttt atg gaa gat tat acc tac cat ttt   1008
Ala Lys Gly Lys Arg Thr Ser Phe Met Glu Asp Tyr Thr Tyr His Phe
                325                 330                 335
 
gaa ccg ggt aat gaa atg att ttg ggt tct cac atg ttg gaa gtt tgt   1056
Glu Pro Gly Asn Glu Met Ile Leu Gly Ser His Met Leu Glu Val Cys
            340                 345                 350
 
ccg acc gtt gcc tta gat cag ccg aaa att gaa gtt cat tct ttg tct   1104
Pro Thr Val Ala Leu Asp Gln Pro Lys Ile Glu Val His Ser Leu Ser
        355                 360                 365
 
att ggt ggt aaa gaa gat ccg gct cgc ctg gtt ttt aat ggc att tcg   1152
Ile Gly Gly Lys Glu Asp Pro Ala Arg Leu Val Phe Asn Gly Ile Ser
    370                 375                 380
 
ggt tct gct atc cag gcc tct att gtt gac att ggt ggt cgt ttt cgt   1200
Gly Ser Ala Ile Gln Ala Ser Ile Val Asp Ile Gly Gly Arg Phe Arg
385                 390                 395                 400
 
ttg gtg ctc aat gaa gtt aat ggc cag gaa att gaa aaa gat atg ccg   1248
Leu Val Leu Asn Glu Val Asn Gly Gln Glu Ile Glu Lys Asp Met Pro
                405                 410                 415
 
aac ttg ccg gtt gct cgt gtt ttg tgg aaa cca gaa ccg tct ttg aaa   1296
Asn Leu Pro Val Ala Arg Val Leu Trp Lys Pro Glu Pro Ser Leu Lys
            420                 425                 430
 
acg gca gct gag gct tgg att ttg gct ggt ggc gca cat cat acc tgt   1344
Thr Ala Ala Glu Ala Trp Ile Leu Ala Gly Gly Ala His His Thr Cys
        435                 440                 445
 
ttg tct tat gaa ttg act gca gag cag atg ttg gat tgg gct gaa atg   1392
Leu Ser Tyr Glu Leu Thr Ala Glu Gln Met Leu Asp Trp Ala Glu Met
    450                 455                 460
 
gca gga atc gaa tct gtt ttg att tct cgt gat acc acc att cat aaa   1440
Ala Gly Ile Glu Ser Val Leu Ile Ser Arg Asp Thr Thr Ile His Lys
465                 470                 475                 480
 
ttg aaa cat gaa ttg aaa tgg aat gag gca tta tat cgt ttg cag aaa   1488
Leu Lys His Glu Leu Lys Trp Asn Glu Ala Leu Tyr Arg Leu Gln Lys
                485                 490                 495
 


<210> 300
<211> 496
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in Z. mobilis

<400> 300
Met Leu Gln Thr Lys Asp Tyr Glu Phe Trp Phe Val Thr Gly Ser Gln
 1               5                  10                  15      
His Leu Tyr Gly Glu Glu Thr Leu Glu Leu Val Asp Gln His Ala Lys
            20                  25                  30          
Ser Ile Cys Glu Gly Leu Ser Gly Ile Ser Ser Arg Tyr Lys Ile Thr
        35                  40                  45              
His Lys Pro Val Val Thr Ser Pro Glu Thr Ile Arg Glu Leu Leu Arg
    50                  55                  60                  
Glu Ala Glu Tyr Ser Glu Thr Cys Ala Gly Ile Ile Thr Trp Met His
65                  70                  75                  80  
Thr Phe Ser Pro Ala Lys Met Trp Ile Glu Gly Leu Ser Ser Tyr Gln
                85                  90                  95      
Lys Pro Leu Met His Leu His Thr Gln Tyr Asn Arg Asp Ile Pro Trp
            100                 105                 110         
Gly Thr Ile Asp Met Asp Phe Met Asn Ser Asn Gln Ser Ala His Gly
        115                 120                 125             
Asp Arg Glu Tyr Gly Tyr Ile Asn Ser Arg Met Gly Leu Ser Arg Lys
    130                 135                 140                 
Val Ile Ala Gly Tyr Trp Asp Asp Glu Glu Val Lys Lys Glu Met Ser
145                 150                 155                 160 
Gln Trp Met Asp Thr Ala Ala Ala Leu Asn Glu Ser Arg His Ile Lys
                165                 170                 175     
Val Ala Arg Phe Gly Asp Asn Met Arg His Val Ala Val Thr Asp Gly
            180                 185                 190         
Asp Lys Val Gly Ala His Ile Gln Phe Gly Trp Gln Val Asp Gly Tyr
        195                 200                 205             
Gly Ile Gly Asp Leu Val Glu Val Met Asp Arg Ile Thr Asp Asp Glu
    210                 215                 220                 
Val Asp Thr Leu Tyr Ala Glu Tyr Asp Arg Leu Tyr Val Ile Ser Glu
225                 230                 235                 240 
Glu Thr Lys Arg Asp Glu Ala Lys Val Ala Ser Ile Lys Glu Gln Ala
                245                 250                 255     
Lys Ile Glu Leu Gly Leu Thr Ala Phe Leu Glu Gln Gly Gly Tyr Thr
            260                 265                 270         
Ala Phe Thr Thr Ser Phe Glu Val Leu His Gly Met Lys Gln Leu Pro
        275                 280                 285             
Gly Leu Ala Val Gln Arg Leu Met Glu Lys Gly Tyr Gly Phe Ala Gly
    290                 295                 300                 
Glu Gly Asp Trp Lys Thr Ala Ala Leu Val Arg Met Met Lys Ile Met
305                 310                 315                 320 
Ala Lys Gly Lys Arg Thr Ser Phe Met Glu Asp Tyr Thr Tyr His Phe
                325                 330                 335     
Glu Pro Gly Asn Glu Met Ile Leu Gly Ser His Met Leu Glu Val Cys
            340                 345                 350         
Pro Thr Val Ala Leu Asp Gln Pro Lys Ile Glu Val His Ser Leu Ser
        355                 360                 365             
Ile Gly Gly Lys Glu Asp Pro Ala Arg Leu Val Phe Asn Gly Ile Ser
    370                 375                 380                 
Gly Ser Ala Ile Gln Ala Ser Ile Val Asp Ile Gly Gly Arg Phe Arg
385                 390                 395                 400 
Leu Val Leu Asn Glu Val Asn Gly Gln Glu Ile Glu Lys Asp Met Pro
                405                 410                 415     
Asn Leu Pro Val Ala Arg Val Leu Trp Lys Pro Glu Pro Ser Leu Lys
            420                 425                 430         
Thr Ala Ala Glu Ala Trp Ile Leu Ala Gly Gly Ala His His Thr Cys
        435                 440                 445             
Leu Ser Tyr Glu Leu Thr Ala Glu Gln Met Leu Asp Trp Ala Glu Met
    450                 455                 460                 
Ala Gly Ile Glu Ser Val Leu Ile Ser Arg Asp Thr Thr Ile His Lys
465                 470                 475                 480 
Leu Lys His Glu Leu Lys Trp Asn Glu Ala Leu Tyr Arg Leu Gln Lys
                485                 490                 495     


<210> 301
<211> 1482
<212> DNA
<213> B. licheniformis

<220> 
<221> CDS            
<222> (1)...(1482)

<400> 301
atg att cag gca aag acg cat gtg ttt tgg ttt gtg aca ggc agc cag   48
Met Ile Gln Ala Lys Thr His Val Phe Trp Phe Val Thr Gly Ser Gln
 1               5                   10                  15
 
cat tta tat ggc gaa gag gcg gta caa gag gta gaa gag cat tcc aaa   96
His Leu Tyr Gly Glu Glu Ala Val Gln Glu Val Glu Glu His Ser Lys
             20                  25                  30
 
atg atc tgc aac gga tta aat gac gga gat tta agg ttt caa gtc gag   144
Met Ile Cys Asn Gly Leu Asn Asp Gly Asp Leu Arg Phe Gln Val Glu
         35                  40                  45
 
tac aaa gcg gtg gcc act tcg ctg gac ggc gtc aga aaa ctg ttt gaa   192
Tyr Lys Ala Val Ala Thr Ser Leu Asp Gly Val Arg Lys Leu Phe Glu
     50                  55                  60
 
gag gcg aac cgg gac gaa gag tgc gca ggc atc atc acc tgg atg cat   240
Glu Ala Asn Arg Asp Glu Glu Cys Ala Gly Ile Ile Thr Trp Met His
 65                  70                  75                  80
 
acg ttt tca ccg gcc aaa atg tgg att ccc ggc ctt tcc gag ctg aat   288
Thr Phe Ser Pro Ala Lys Met Trp Ile Pro Gly Leu Ser Glu Leu Asn
                 85                  90                  95
 
aag ccg ctg ctc cat ttt cat acc cag ttt aac cgg gac att ccg tgg   336
Lys Pro Leu Leu His Phe His Thr Gln Phe Asn Arg Asp Ile Pro Trp
            100                 105                 110
 
gat aaa atc gac atg gat ttc atg aat att aat cag tct gcc cac ggc   384
Asp Lys Ile Asp Met Asp Phe Met Asn Ile Asn Gln Ser Ala His Gly
        115                 120                 125
 
gac cgc gaa tac ggt ttt atc gga gcg aga ttg ggc att cct cga aaa   432
Asp Arg Glu Tyr Gly Phe Ile Gly Ala Arg Leu Gly Ile Pro Arg Lys
    130                 135                 140
 
gta atc gcc gga tat tgg gaa gac aga gaa gta aag cgc tcg atc gac   480
Val Ile Ala Gly Tyr Trp Glu Asp Arg Glu Val Lys Arg Ser Ile Asp
145                 150                 155                 160
 
aaa tgg atg agc gca gcg gtc gca tat att gaa agc cgc cat atc aaa   528
Lys Trp Met Ser Ala Ala Val Ala Tyr Ile Glu Ser Arg His Ile Lys
                165                 170                 175
 
gtc gcc cga ttt ggg gac aac atg cgg aat gtg gcg gta aca gaa gga   576
Val Ala Arg Phe Gly Asp Asn Met Arg Asn Val Ala Val Thr Glu Gly
            180                 185                 190
 
gat aag att gaa gcg cag att cag ctt ggc tgg tct gtc gac gga tat   624
Asp Lys Ile Glu Ala Gln Ile Gln Leu Gly Trp Ser Val Asp Gly Tyr
        195                 200                 205
 
gga atc ggc gat ctc gtc acg gag atc aat gct gta tca gaa cag agt   672
Gly Ile Gly Asp Leu Val Thr Glu Ile Asn Ala Val Ser Glu Gln Ser
    210                 215                 220
 
cta agc gag ctc atc tcc gaa tat gag gag ctt tat gag tgg ccg gaa   720
Leu Ser Glu Leu Ile Ser Glu Tyr Glu Glu Leu Tyr Glu Trp Pro Glu
225                 230                 235                 240
 
ggc gaa gcg gca agg gaa tcc gtc aag gag cag gcg cgg att gag ctt   768
Gly Glu Ala Ala Arg Glu Ser Val Lys Glu Gln Ala Arg Ile Glu Leu
                245                 250                 255
 
gga tta aag cgc ttt ctt tcg agc gga ggc tat acg gcc ttt acg aca   816
Gly Leu Lys Arg Phe Leu Ser Ser Gly Gly Tyr Thr Ala Phe Thr Thr
            260                 265                 270
 
acc ttt gaa gac ctc cac ggc atg aag cag ctt ccg ggt ttg gct gtt   864
Thr Phe Glu Asp Leu His Gly Met Lys Gln Leu Pro Gly Leu Ala Val
        275                 280                 285
 
cag cgg ctg atg gct gaa ggc tat ggc ttt gga gga gaa gga gat tgg   912
Gln Arg Leu Met Ala Glu Gly Tyr Gly Phe Gly Gly Glu Gly Asp Trp
    290                 295                 300
 
aaa acg gct gcg ctt gtc agg atg atg aaa atg atg gcc ggc gga aaa   960
Lys Thr Ala Ala Leu Val Arg Met Met Lys Met Met Ala Gly Gly Lys
305                 310                 315                 320
 
gaa acg tca ttt atg gag gat tac acg tac cat ttt gaa ccg ggc aat   1008
Glu Thr Ser Phe Met Glu Asp Tyr Thr Tyr His Phe Glu Pro Gly Asn
                325                 330                 335
 
gaa atg atc ctc ggc tcc cac atg ctt gaa gtg tgc cct tcg att gcc   1056
Glu Met Ile Leu Gly Ser His Met Leu Glu Val Cys Pro Ser Ile Ala
            340                 345                 350
 
gaa cac aaa ccg aga att gaa gtc cat ccg ctg tca atg ggt gca aag   1104
Glu His Lys Pro Arg Ile Glu Val His Pro Leu Ser Met Gly Ala Lys
        355                 360                 365
 
gat gat ccg gcg cgg ctc gtg ttt gac gga att gca ggt cct gcg gtc   1152
Asp Asp Pro Ala Arg Leu Val Phe Asp Gly Ile Ala Gly Pro Ala Val
    370                 375                 380
 
aat gtc tcc ctt att gat ttg ggc gga cgt ttc agg ctt gtc atc aat   1200
Asn Val Ser Leu Ile Asp Leu Gly Gly Arg Phe Arg Leu Val Ile Asn
385                 390                 395                 400
 
aaa gtg gaa gct gtg aag gtt ccg cat gat atg ccg aat ctt ccg gtg   1248
Lys Val Glu Ala Val Lys Val Pro His Asp Met Pro Asn Leu Pro Val
                405                 410                 415
 
gcg cgc gta ctt tgg aag cct cag ccg tct ctg aga aca tcg gct gaa   1296
Ala Arg Val Leu Trp Lys Pro Gln Pro Ser Leu Arg Thr Ser Ala Glu
            420                 425                 430
 
gcg tgg att ttg gct ggc ggt gct cac cat aca tgc ctt tcg tac cag   1344
Ala Trp Ile Leu Ala Gly Gly Ala His His Thr Cys Leu Ser Tyr Gln
        435                 440                 445
 
ctg aca gcc gag cag atg ctc gat tgg gcc gaa atg tcg ggc att gaa   1392
Leu Thr Ala Glu Gln Met Leu Asp Trp Ala Glu Met Ser Gly Ile Glu
    450                 455                 460
 
gcg gtg ttg atc aat cgt gat aca acg att tta aat ctt cgc aat gaa   1440
Ala Val Leu Ile Asn Arg Asp Thr Thr Ile Leu Asn Leu Arg Asn Glu
465                 470                 475                 480
 
ctc aaa tgg agt gaa gct gca tat cgg ctt cgc aag ttt taa           1482
Leu Lys Trp Ser Glu Ala Ala Tyr Arg Leu Arg Lys Phe  *
                485                 490
 


<210> 302
<211> 493
<212> PRT
<213> B. licheniformis

<400> 302
Met Ile Gln Ala Lys Thr His Val Phe Trp Phe Val Thr Gly Ser Gln
 1               5                  10                  15      
His Leu Tyr Gly Glu Glu Ala Val Gln Glu Val Glu Glu His Ser Lys
            20                  25                  30          
Met Ile Cys Asn Gly Leu Asn Asp Gly Asp Leu Arg Phe Gln Val Glu
        35                  40                  45              
Tyr Lys Ala Val Ala Thr Ser Leu Asp Gly Val Arg Lys Leu Phe Glu
    50                  55                  60                  
Glu Ala Asn Arg Asp Glu Glu Cys Ala Gly Ile Ile Thr Trp Met His
65                  70                  75                  80  
Thr Phe Ser Pro Ala Lys Met Trp Ile Pro Gly Leu Ser Glu Leu Asn
                85                  90                  95      
Lys Pro Leu Leu His Phe His Thr Gln Phe Asn Arg Asp Ile Pro Trp
            100                 105                 110         
Asp Lys Ile Asp Met Asp Phe Met Asn Ile Asn Gln Ser Ala His Gly
        115                 120                 125             
Asp Arg Glu Tyr Gly Phe Ile Gly Ala Arg Leu Gly Ile Pro Arg Lys
    130                 135                 140                 
Val Ile Ala Gly Tyr Trp Glu Asp Arg Glu Val Lys Arg Ser Ile Asp
145                 150                 155                 160 
Lys Trp Met Ser Ala Ala Val Ala Tyr Ile Glu Ser Arg His Ile Lys
                165                 170                 175     
Val Ala Arg Phe Gly Asp Asn Met Arg Asn Val Ala Val Thr Glu Gly
            180                 185                 190         
Asp Lys Ile Glu Ala Gln Ile Gln Leu Gly Trp Ser Val Asp Gly Tyr
        195                 200                 205             
Gly Ile Gly Asp Leu Val Thr Glu Ile Asn Ala Val Ser Glu Gln Ser
    210                 215                 220                 
Leu Ser Glu Leu Ile Ser Glu Tyr Glu Glu Leu Tyr Glu Trp Pro Glu
225                 230                 235                 240 
Gly Glu Ala Ala Arg Glu Ser Val Lys Glu Gln Ala Arg Ile Glu Leu
                245                 250                 255     
Gly Leu Lys Arg Phe Leu Ser Ser Gly Gly Tyr Thr Ala Phe Thr Thr
            260                 265                 270         
Thr Phe Glu Asp Leu His Gly Met Lys Gln Leu Pro Gly Leu Ala Val
        275                 280                 285             
Gln Arg Leu Met Ala Glu Gly Tyr Gly Phe Gly Gly Glu Gly Asp Trp
    290                 295                 300                 
Lys Thr Ala Ala Leu Val Arg Met Met Lys Met Met Ala Gly Gly Lys
305                 310                 315                 320 
Glu Thr Ser Phe Met Glu Asp Tyr Thr Tyr His Phe Glu Pro Gly Asn
                325                 330                 335     
Glu Met Ile Leu Gly Ser His Met Leu Glu Val Cys Pro Ser Ile Ala
            340                 345                 350         
Glu His Lys Pro Arg Ile Glu Val His Pro Leu Ser Met Gly Ala Lys
        355                 360                 365             
Asp Asp Pro Ala Arg Leu Val Phe Asp Gly Ile Ala Gly Pro Ala Val
    370                 375                 380                 
Asn Val Ser Leu Ile Asp Leu Gly Gly Arg Phe Arg Leu Val Ile Asn
385                 390                 395                 400 
Lys Val Glu Ala Val Lys Val Pro His Asp Met Pro Asn Leu Pro Val
                405                 410                 415     
Ala Arg Val Leu Trp Lys Pro Gln Pro Ser Leu Arg Thr Ser Ala Glu
            420                 425                 430         
Ala Trp Ile Leu Ala Gly Gly Ala His His Thr Cys Leu Ser Tyr Gln
        435                 440                 445             
Leu Thr Ala Glu Gln Met Leu Asp Trp Ala Glu Met Ser Gly Ile Glu
    450                 455                 460                 
Ala Val Leu Ile Asn Arg Asp Thr Thr Ile Leu Asn Leu Arg Asn Glu
465                 470                 475                 480 
Leu Lys Trp Ser Glu Ala Ala Tyr Arg Leu Arg Lys Phe
                485                 490             


<210> 303
<211> 1479
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in S. cerevisiae

<220> 
<221> CDS            
<222> (1)...(1479)

<400> 303
atg ata caa gct aaa act cat gtg ttc tgg ttc gtt act ggt tca caa   48
Met Ile Gln Ala Lys Thr His Val Phe Trp Phe Val Thr Gly Ser Gln
 1               5                   10                  15
 
cat ttg tat ggt gaa gaa gct gtt caa gaa gtt gaa gaa cat tct aaa   96
His Leu Tyr Gly Glu Glu Ala Val Gln Glu Val Glu Glu His Ser Lys
             20                  25                  30
 
atg att tgt aat ggt tta aat gat ggt gat ttg aga ttt caa gtt gaa   144
Met Ile Cys Asn Gly Leu Asn Asp Gly Asp Leu Arg Phe Gln Val Glu
         35                  40                  45
 
tat aaa gct gtt gct aca tct ctt gat ggt gtt aga aaa ttg ttt gaa   192
Tyr Lys Ala Val Ala Thr Ser Leu Asp Gly Val Arg Lys Leu Phe Glu
     50                  55                  60
 
gag gct aat aga gat gaa gaa tgt gct gga ata att act tgg atg cat   240
Glu Ala Asn Arg Asp Glu Glu Cys Ala Gly Ile Ile Thr Trp Met His
 65                  70                  75                  80
 
act ttt tca cca gct aaa atg tgg att cca ggt ttg tct gaa ctt aat   288
Thr Phe Ser Pro Ala Lys Met Trp Ile Pro Gly Leu Ser Glu Leu Asn
                 85                  90                  95
 
aaa cca ttg ttg cat ttt cat act caa ttt aat aga gat ata cca tgg   336
Lys Pro Leu Leu His Phe His Thr Gln Phe Asn Arg Asp Ile Pro Trp
            100                 105                 110
 
gat aaa att gat atg gat ttt atg aac att aat caa tct gct cat ggt   384
Asp Lys Ile Asp Met Asp Phe Met Asn Ile Asn Gln Ser Ala His Gly
        115                 120                 125
 
gat aga gaa tat ggt ttt att ggt gct aga ttg gga ata cca cgt aag   432
Asp Arg Glu Tyr Gly Phe Ile Gly Ala Arg Leu Gly Ile Pro Arg Lys
    130                 135                 140
 
gta att gct ggt tat tgg gaa gat aga gaa gtt aaa aga tct att gat   480
Val Ile Ala Gly Tyr Trp Glu Asp Arg Glu Val Lys Arg Ser Ile Asp
145                 150                 155                 160
 
aag tgg atg tct gct gct gtt gct tat att gaa tct aga cat att aag   528
Lys Trp Met Ser Ala Ala Val Ala Tyr Ile Glu Ser Arg His Ile Lys
                165                 170                 175
 
gtt gct aga ttt gga gat aat atg aga aat gtt gct gtt act gaa ggt   576
Val Ala Arg Phe Gly Asp Asn Met Arg Asn Val Ala Val Thr Glu Gly
            180                 185                 190
 
gat aaa att gaa gct caa att cag ttg ggt tgg tct gtt gat ggt tat   624
Asp Lys Ile Glu Ala Gln Ile Gln Leu Gly Trp Ser Val Asp Gly Tyr
        195                 200                 205
 
gga att ggt gat ttg gtt act gaa att aat gct gta tct gaa caa tct   672
Gly Ile Gly Asp Leu Val Thr Glu Ile Asn Ala Val Ser Glu Gln Ser
    210                 215                 220
 
ttg tct gaa tta att tct gaa tat gaa gaa ttg tat gaa tgg cca gaa   720
Leu Ser Glu Leu Ile Ser Glu Tyr Glu Glu Leu Tyr Glu Trp Pro Glu
225                 230                 235                 240
 
ggt gaa gct gct aga gaa tct gtt aaa gaa caa gct aga att gaa ttg   768
Gly Glu Ala Ala Arg Glu Ser Val Lys Glu Gln Ala Arg Ile Glu Leu
                245                 250                 255
 
ggt tta aag aga ttt ttg tct tct ggt ggt tat act gct ttt act act   816
Gly Leu Lys Arg Phe Leu Ser Ser Gly Gly Tyr Thr Ala Phe Thr Thr
            260                 265                 270
 
act ttt gaa gat ttg cat ggt atg aaa caa ttg cca ggt tta gct gtt   864
Thr Phe Glu Asp Leu His Gly Met Lys Gln Leu Pro Gly Leu Ala Val
        275                 280                 285
 
caa aga ttg atg gct gaa gga tat ggt ttc ggt ggt gaa ggg gat tgg   912
Gln Arg Leu Met Ala Glu Gly Tyr Gly Phe Gly Gly Glu Gly Asp Trp
    290                 295                 300
 
aaa act gct gct ttg gtt aga atg atg aaa atg atg gct ggt ggg aaa   960
Lys Thr Ala Ala Leu Val Arg Met Met Lys Met Met Ala Gly Gly Lys
305                 310                 315                 320
 
gaa aca agt ttt atg gaa gat tat act tat cat ttt gaa cca ggt aat   1008
Glu Thr Ser Phe Met Glu Asp Tyr Thr Tyr His Phe Glu Pro Gly Asn
                325                 330                 335
 
gaa atg att ttg ggt tct cac atg ttg gaa gtt tgt cca tct att gct   1056
Glu Met Ile Leu Gly Ser His Met Leu Glu Val Cys Pro Ser Ile Ala
            340                 345                 350
 
gaa cat aaa cca agg att gaa gtt cat cca ctt agt atg ggt gct aaa   1104
Glu His Lys Pro Arg Ile Glu Val His Pro Leu Ser Met Gly Ala Lys
        355                 360                 365
 
gat gat cca gct aga ttg gtt ttt gat gga att gcg ggt cct gca gtt   1152
Asp Asp Pro Ala Arg Leu Val Phe Asp Gly Ile Ala Gly Pro Ala Val
    370                 375                 380
 
aat gtt tca ttg att gat ttg ggt ggt aga ttt aga ttg gta att aat   1200
Asn Val Ser Leu Ile Asp Leu Gly Gly Arg Phe Arg Leu Val Ile Asn
385                 390                 395                 400
 
aag gtt gaa gct gtt aag gtt cca cat gat atg cca aat ttg ccg gtt   1248
Lys Val Glu Ala Val Lys Val Pro His Asp Met Pro Asn Leu Pro Val
                405                 410                 415
 
gct aga gtt ttg tgg aaa cct cag cct agc ttg aga act agc gct gaa   1296
Ala Arg Val Leu Trp Lys Pro Gln Pro Ser Leu Arg Thr Ser Ala Glu
            420                 425                 430
 
gca tgg att ttg gct ggt ggt gct cat cat act tgt ttg tct tat caa   1344
Ala Trp Ile Leu Ala Gly Gly Ala His His Thr Cys Leu Ser Tyr Gln
        435                 440                 445
 
ttg act gct gaa caa atg ttg gat tgg gct gaa atg tct gga att gaa   1392
Leu Thr Ala Glu Gln Met Leu Asp Trp Ala Glu Met Ser Gly Ile Glu
    450                 455                 460
 
gct gtt ttg att aat aga gac act act att tta aat ttg aga aat gaa   1440
Ala Val Leu Ile Asn Arg Asp Thr Thr Ile Leu Asn Leu Arg Asn Glu
465                 470                 475                 480
 
tta aaa tgg tct gaa gcg gct tat aga ttg aga aaa ttt               1479
Leu Lys Trp Ser Glu Ala Ala Tyr Arg Leu Arg Lys Phe
                485                 490
 

<210> 304
<211> 493
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in S. cerevisiae

<400> 304
Met Ile Gln Ala Lys Thr His Val Phe Trp Phe Val Thr Gly Ser Gln
 1               5                  10                  15      
His Leu Tyr Gly Glu Glu Ala Val Gln Glu Val Glu Glu His Ser Lys
            20                  25                  30          
Met Ile Cys Asn Gly Leu Asn Asp Gly Asp Leu Arg Phe Gln Val Glu
        35                  40                  45              
Tyr Lys Ala Val Ala Thr Ser Leu Asp Gly Val Arg Lys Leu Phe Glu
    50                  55                  60                  
Glu Ala Asn Arg Asp Glu Glu Cys Ala Gly Ile Ile Thr Trp Met His
65                  70                  75                  80  
Thr Phe Ser Pro Ala Lys Met Trp Ile Pro Gly Leu Ser Glu Leu Asn
                85                  90                  95      
Lys Pro Leu Leu His Phe His Thr Gln Phe Asn Arg Asp Ile Pro Trp
            100                 105                 110         
Asp Lys Ile Asp Met Asp Phe Met Asn Ile Asn Gln Ser Ala His Gly
        115                 120                 125             
Asp Arg Glu Tyr Gly Phe Ile Gly Ala Arg Leu Gly Ile Pro Arg Lys
    130                 135                 140                 
Val Ile Ala Gly Tyr Trp Glu Asp Arg Glu Val Lys Arg Ser Ile Asp
145                 150                 155                 160 
Lys Trp Met Ser Ala Ala Val Ala Tyr Ile Glu Ser Arg His Ile Lys
                165                 170                 175     
Val Ala Arg Phe Gly Asp Asn Met Arg Asn Val Ala Val Thr Glu Gly
            180                 185                 190         
Asp Lys Ile Glu Ala Gln Ile Gln Leu Gly Trp Ser Val Asp Gly Tyr
        195                 200                 205             
Gly Ile Gly Asp Leu Val Thr Glu Ile Asn Ala Val Ser Glu Gln Ser
    210                 215                 220                 
Leu Ser Glu Leu Ile Ser Glu Tyr Glu Glu Leu Tyr Glu Trp Pro Glu
225                 230                 235                 240 
Gly Glu Ala Ala Arg Glu Ser Val Lys Glu Gln Ala Arg Ile Glu Leu
                245                 250                 255     
Gly Leu Lys Arg Phe Leu Ser Ser Gly Gly Tyr Thr Ala Phe Thr Thr
            260                 265                 270         
Thr Phe Glu Asp Leu His Gly Met Lys Gln Leu Pro Gly Leu Ala Val
        275                 280                 285             
Gln Arg Leu Met Ala Glu Gly Tyr Gly Phe Gly Gly Glu Gly Asp Trp
    290                 295                 300                 
Lys Thr Ala Ala Leu Val Arg Met Met Lys Met Met Ala Gly Gly Lys
305                 310                 315                 320 
Glu Thr Ser Phe Met Glu Asp Tyr Thr Tyr His Phe Glu Pro Gly Asn
                325                 330                 335     
Glu Met Ile Leu Gly Ser His Met Leu Glu Val Cys Pro Ser Ile Ala
            340                 345                 350         
Glu His Lys Pro Arg Ile Glu Val His Pro Leu Ser Met Gly Ala Lys
        355                 360                 365             
Asp Asp Pro Ala Arg Leu Val Phe Asp Gly Ile Ala Gly Pro Ala Val
    370                 375                 380                 
Asn Val Ser Leu Ile Asp Leu Gly Gly Arg Phe Arg Leu Val Ile Asn
385                 390                 395                 400 
Lys Val Glu Ala Val Lys Val Pro His Asp Met Pro Asn Leu Pro Val
                405                 410                 415     
Ala Arg Val Leu Trp Lys Pro Gln Pro Ser Leu Arg Thr Ser Ala Glu
            420                 425                 430         
Ala Trp Ile Leu Ala Gly Gly Ala His His Thr Cys Leu Ser Tyr Gln
        435                 440                 445             
Leu Thr Ala Glu Gln Met Leu Asp Trp Ala Glu Met Ser Gly Ile Glu
    450                 455                 460                 
Ala Val Leu Ile Asn Arg Asp Thr Thr Ile Leu Asn Leu Arg Asn Glu
465                 470                 475                 480 
Leu Lys Trp Ser Glu Ala Ala Tyr Arg Leu Arg Lys Phe
                485                 490             


<210> 305
<211> 1479
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in E. coli

<220> 
<221> CDS            
<222> (1)...(1479)

<400> 305
atg atc caa gcg aaa acc cac gta ttt tgg ttc gtt acc ggt tct cag   48
Met Ile Gln Ala Lys Thr His Val Phe Trp Phe Val Thr Gly Ser Gln
 1               5                   10                  15
 
cac ctg tac ggt gaa gaa gct gtt cag gaa gtt gaa gaa cac tct aaa   96
His Leu Tyr Gly Glu Glu Ala Val Gln Glu Val Glu Glu His Ser Lys
             20                  25                  30
 
atg atc tgc aac ggt ctg aac gac ggt gac ctg cgt ttc caa gtt gaa   144
Met Ile Cys Asn Gly Leu Asn Asp Gly Asp Leu Arg Phe Gln Val Glu
         35                  40                  45
 
tac aag gcg gtt gcg acc tct ctg gac ggt gtt cgt aaa ctg ttc gaa   192
Tyr Lys Ala Val Ala Thr Ser Leu Asp Gly Val Arg Lys Leu Phe Glu
     50                  55                  60
 
gaa gca aac cgt gac gaa gaa tgc gcg ggt atc atc act tgg atg cac   240
Glu Ala Asn Arg Asp Glu Glu Cys Ala Gly Ile Ile Thr Trp Met His
 65                  70                  75                  80
 
acc ttc tct ccg gcg aaa atg tgg atc cca ggt ctg tct gaa ctg aac   288
Thr Phe Ser Pro Ala Lys Met Trp Ile Pro Gly Leu Ser Glu Leu Asn
                 85                  90                  95
 
aaa cca ctg ctg cac ttc cac acc cag ttc aac cgt gat att ccg tgg   336
Lys Pro Leu Leu His Phe His Thr Gln Phe Asn Arg Asp Ile Pro Trp
            100                 105                 110
 
gac aaa atc gat atg gac ttc atg aac atc aac cag tct gcg cac ggc   384
Asp Lys Ile Asp Met Asp Phe Met Asn Ile Asn Gln Ser Ala His Gly
        115                 120                 125
 
gac cgt gaa tac ggc ttc atc ggt gcg cgt ctg ggt atc cct cgc aaa   432
Asp Arg Glu Tyr Gly Phe Ile Gly Ala Arg Leu Gly Ile Pro Arg Lys
    130                 135                 140
 
gtt atc gct ggt tat tgg gaa gac cgt gaa gtt aaa cgt tct atc gat   480
Val Ile Ala Gly Tyr Trp Glu Asp Arg Glu Val Lys Arg Ser Ile Asp
145                 150                 155                 160
 
aaa tgg atg tct gcg gct gtg gca tac atc gaa tct cgt cac atc aaa   528
Lys Trp Met Ser Ala Ala Val Ala Tyr Ile Glu Ser Arg His Ile Lys
                165                 170                 175
 
gtt gct cgc ttc ggt gac aac atg cgt aac gtt gcg gtt acc gaa ggt   576
Val Ala Arg Phe Gly Asp Asn Met Arg Asn Val Ala Val Thr Glu Gly
            180                 185                 190
 
gac aaa atc gag gcg cag atc cag ttg ggt tgg tct gtt gac ggt tac   624
Asp Lys Ile Glu Ala Gln Ile Gln Leu Gly Trp Ser Val Asp Gly Tyr
        195                 200                 205
 
ggt atc ggt gac ttg gtt acc gag atc aac gcg gtc tct gaa cag tct   672
Gly Ile Gly Asp Leu Val Thr Glu Ile Asn Ala Val Ser Glu Gln Ser
    210                 215                 220
 
ctg tcc gaa ttg atc tct gaa tac gaa gaa ctg tac gaa tgg ccg gaa   720
Leu Ser Glu Leu Ile Ser Glu Tyr Glu Glu Leu Tyr Glu Trp Pro Glu
225                 230                 235                 240
 
ggc gaa gct gct cgt gaa tct gtt aaa gaa cag gct cgt atc gaa ctg   768
Gly Glu Ala Ala Arg Glu Ser Val Lys Glu Gln Ala Arg Ile Glu Leu
                245                 250                 255
 
ggc ctg aaa cgt ttc ctg tct tct ggt ggt tac acc gct ttc acc acc   816
Gly Leu Lys Arg Phe Leu Ser Ser Gly Gly Tyr Thr Ala Phe Thr Thr
            260                 265                 270
 
acc ttc gaa gac ctg cat ggt atg aaa cag ctg cct ggt ttg gct gtg   864
Thr Phe Glu Asp Leu His Gly Met Lys Gln Leu Pro Gly Leu Ala Val
        275                 280                 285
 
caa cgc ttg atg gca gaa ggc tat ggt ttc ggt ggt gag ggt gat tgg   912
Gln Arg Leu Met Ala Glu Gly Tyr Gly Phe Gly Gly Glu Gly Asp Trp
    290                 295                 300
 
aaa acg gcg gct ctt gtt cgc atg atg aaa atg atg gct ggt ggc aaa   960
Lys Thr Ala Ala Leu Val Arg Met Met Lys Met Met Ala Gly Gly Lys
305                 310                 315                 320
 
gaa acc tct ttc atg gaa gac tac acc tac cac ttc gaa ccg ggt aac   1008
Glu Thr Ser Phe Met Glu Asp Tyr Thr Tyr His Phe Glu Pro Gly Asn
                325                 330                 335
 
gaa atg atc ctg ggt tct cac atg ctc gaa gtt tgc ccg tct atc gcg   1056
Glu Met Ile Leu Gly Ser His Met Leu Glu Val Cys Pro Ser Ile Ala
            340                 345                 350
 
gaa cac aaa cca cgt atc gaa gtt cac cca ctg tct atg ggc gct aaa   1104
Glu His Lys Pro Arg Ile Glu Val His Pro Leu Ser Met Gly Ala Lys
        355                 360                 365
 
gat gac cca gct cgt ttg gtt ttc gac ggc att gcg ggc cct gct gtg   1152
Asp Asp Pro Ala Arg Leu Val Phe Asp Gly Ile Ala Gly Pro Ala Val
    370                 375                 380
 
aac gtg tct ctg att gac ttg ggt ggt cgt ttt cgt ctg gtt att aac   1200
Asn Val Ser Leu Ile Asp Leu Gly Gly Arg Phe Arg Leu Val Ile Asn
385                 390                 395                 400
 
aaa gtt gaa gca gtt aaa gtt ccg cac gac atg cct aac ctg ccg gtt   1248
Lys Val Glu Ala Val Lys Val Pro His Asp Met Pro Asn Leu Pro Val
                405                 410                 415
 
gct cgt gtt ctc tgg aaa cca caa cct agc ctc cgt acc tct gcc gaa   1296
Ala Arg Val Leu Trp Lys Pro Gln Pro Ser Leu Arg Thr Ser Ala Glu
            420                 425                 430
 
gca tgg atc ttg gcg ggt ggt gct cat cat acc tgc ttg tct tac cag   1344
Ala Trp Ile Leu Ala Gly Gly Ala His His Thr Cys Leu Ser Tyr Gln
        435                 440                 445
 
ctg acc gca gaa cag atg ctg gat tgg gca gaa atg tct ggt atc gaa   1392
Leu Thr Ala Glu Gln Met Leu Asp Trp Ala Glu Met Ser Gly Ile Glu
    450                 455                 460
 
gca gtt ctg atc aat cgt gac acc acc att ctg aac ctc cgt aat gaa   1440
Ala Val Leu Ile Asn Arg Asp Thr Thr Ile Leu Asn Leu Arg Asn Glu
465                 470                 475                 480
 
ctg aaa tgg tct gag gca gcc tac cgt ctc cgt aaa ttc               1479
Leu Lys Trp Ser Glu Ala Ala Tyr Arg Leu Arg Lys Phe
                485                 490
 

<210> 306
<211> 493
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in E. coli

<400> 306
Met Ile Gln Ala Lys Thr His Val Phe Trp Phe Val Thr Gly Ser Gln
 1               5                  10                  15      
His Leu Tyr Gly Glu Glu Ala Val Gln Glu Val Glu Glu His Ser Lys
            20                  25                  30          
Met Ile Cys Asn Gly Leu Asn Asp Gly Asp Leu Arg Phe Gln Val Glu
        35                  40                  45              
Tyr Lys Ala Val Ala Thr Ser Leu Asp Gly Val Arg Lys Leu Phe Glu
    50                  55                  60                  
Glu Ala Asn Arg Asp Glu Glu Cys Ala Gly Ile Ile Thr Trp Met His
65                  70                  75                  80  
Thr Phe Ser Pro Ala Lys Met Trp Ile Pro Gly Leu Ser Glu Leu Asn
                85                  90                  95      
Lys Pro Leu Leu His Phe His Thr Gln Phe Asn Arg Asp Ile Pro Trp
            100                 105                 110         
Asp Lys Ile Asp Met Asp Phe Met Asn Ile Asn Gln Ser Ala His Gly
        115                 120                 125             
Asp Arg Glu Tyr Gly Phe Ile Gly Ala Arg Leu Gly Ile Pro Arg Lys
    130                 135                 140                 
Val Ile Ala Gly Tyr Trp Glu Asp Arg Glu Val Lys Arg Ser Ile Asp
145                 150                 155                 160 
Lys Trp Met Ser Ala Ala Val Ala Tyr Ile Glu Ser Arg His Ile Lys
                165                 170                 175     
Val Ala Arg Phe Gly Asp Asn Met Arg Asn Val Ala Val Thr Glu Gly
            180                 185                 190         
Asp Lys Ile Glu Ala Gln Ile Gln Leu Gly Trp Ser Val Asp Gly Tyr
        195                 200                 205             
Gly Ile Gly Asp Leu Val Thr Glu Ile Asn Ala Val Ser Glu Gln Ser
    210                 215                 220                 
Leu Ser Glu Leu Ile Ser Glu Tyr Glu Glu Leu Tyr Glu Trp Pro Glu
225                 230                 235                 240 
Gly Glu Ala Ala Arg Glu Ser Val Lys Glu Gln Ala Arg Ile Glu Leu
                245                 250                 255     
Gly Leu Lys Arg Phe Leu Ser Ser Gly Gly Tyr Thr Ala Phe Thr Thr
            260                 265                 270         
Thr Phe Glu Asp Leu His Gly Met Lys Gln Leu Pro Gly Leu Ala Val
        275                 280                 285             
Gln Arg Leu Met Ala Glu Gly Tyr Gly Phe Gly Gly Glu Gly Asp Trp
    290                 295                 300                 
Lys Thr Ala Ala Leu Val Arg Met Met Lys Met Met Ala Gly Gly Lys
305                 310                 315                 320 
Glu Thr Ser Phe Met Glu Asp Tyr Thr Tyr His Phe Glu Pro Gly Asn
                325                 330                 335     
Glu Met Ile Leu Gly Ser His Met Leu Glu Val Cys Pro Ser Ile Ala
            340                 345                 350         
Glu His Lys Pro Arg Ile Glu Val His Pro Leu Ser Met Gly Ala Lys
        355                 360                 365             
Asp Asp Pro Ala Arg Leu Val Phe Asp Gly Ile Ala Gly Pro Ala Val
    370                 375                 380                 
Asn Val Ser Leu Ile Asp Leu Gly Gly Arg Phe Arg Leu Val Ile Asn
385                 390                 395                 400 
Lys Val Glu Ala Val Lys Val Pro His Asp Met Pro Asn Leu Pro Val
                405                 410                 415     
Ala Arg Val Leu Trp Lys Pro Gln Pro Ser Leu Arg Thr Ser Ala Glu
            420                 425                 430         
Ala Trp Ile Leu Ala Gly Gly Ala His His Thr Cys Leu Ser Tyr Gln
        435                 440                 445             
Leu Thr Ala Glu Gln Met Leu Asp Trp Ala Glu Met Ser Gly Ile Glu
    450                 455                 460                 
Ala Val Leu Ile Asn Arg Asp Thr Thr Ile Leu Asn Leu Arg Asn Glu
465                 470                 475                 480 
Leu Lys Trp Ser Glu Ala Ala Tyr Arg Leu Arg Lys Phe
                485                 490             


<210> 307
<211> 1479
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in P. pastoris

<220> 
<221> CDS            
<222> (1)...(1479)

<400> 307
atg att caa gct aaa act cat gtt ttc tgg ttt gtt act gga tct caa   48
Met Ile Gln Ala Lys Thr His Val Phe Trp Phe Val Thr Gly Ser Gln
 1               5                   10                  15
 
cat ttg tat gga gaa gaa gct gtt caa gaa gtt gaa gaa cat tct aaa   96
His Leu Tyr Gly Glu Glu Ala Val Gln Glu Val Glu Glu His Ser Lys
             20                  25                  30
 
atg att tgt aat gga tta aat gat gga gat ttg aga ttt caa gtt gaa   144
Met Ile Cys Asn Gly Leu Asn Asp Gly Asp Leu Arg Phe Gln Val Glu
         35                  40                  45
 
tat aaa gct gtt gct act tct tta gat gga gtt aga aaa ttg ttt gag   192
Tyr Lys Ala Val Ala Thr Ser Leu Asp Gly Val Arg Lys Leu Phe Glu
     50                  55                  60
 
gaa gct aat aga gat gaa gaa tgt gct gga att att act tgg atg cat   240
Glu Ala Asn Arg Asp Glu Glu Cys Ala Gly Ile Ile Thr Trp Met His
 65                  70                  75                  80
 
act ttt tct cca gct aaa atg tgg att cca gga ttg tct gaa tta aat   288
Thr Phe Ser Pro Ala Lys Met Trp Ile Pro Gly Leu Ser Glu Leu Asn
                 85                  90                  95
 
aaa cct ttg ttg cat ttt cat act caa ttt aat aga gac att cca tgg   336
Lys Pro Leu Leu His Phe His Thr Gln Phe Asn Arg Asp Ile Pro Trp
            100                 105                 110
 
gat aaa att gat atg gat ttt atg aac att aat caa tct gct cat gga   384
Asp Lys Ile Asp Met Asp Phe Met Asn Ile Asn Gln Ser Ala His Gly
        115                 120                 125
 
gat aga gaa tat gga ttt att gga gct aga ttg gga atc cct aga aaa   432
Asp Arg Glu Tyr Gly Phe Ile Gly Ala Arg Leu Gly Ile Pro Arg Lys
    130                 135                 140
 
gtt att gct gga tat tgg gaa gat aga gaa gtt aaa aga tct att gat   480
Val Ile Ala Gly Tyr Trp Glu Asp Arg Glu Val Lys Arg Ser Ile Asp
145                 150                 155                 160
 
aag tgg atg tct gct gct gtc gca tat att gaa agc aga cac att aaa   528
Lys Trp Met Ser Ala Ala Val Ala Tyr Ile Glu Ser Arg His Ile Lys
                165                 170                 175
 
gtt gct aga ttc gga gat aat atg aga aat gtt gct gtt act gaa gga   576
Val Ala Arg Phe Gly Asp Asn Met Arg Asn Val Ala Val Thr Glu Gly
            180                 185                 190
 
gat aaa att gaa gct caa att caa ttg gga tgg tct gtt gat gga tat   624
Asp Lys Ile Glu Ala Gln Ile Gln Leu Gly Trp Ser Val Asp Gly Tyr
        195                 200                 205
 
gga att gga gat tta gtt act gaa att aac gct gtt tct gaa caa tct   672
Gly Ile Gly Asp Leu Val Thr Glu Ile Asn Ala Val Ser Glu Gln Ser
    210                 215                 220
 
tta tct gag ttg att tct gaa tat gaa gaa ttg tat gaa tgg cca gaa   720
Leu Ser Glu Leu Ile Ser Glu Tyr Glu Glu Leu Tyr Glu Trp Pro Glu
225                 230                 235                 240
 
gga gaa gct gct aga gaa tct gtt aaa gaa caa gct aga att gaa ttg   768
Gly Glu Ala Ala Arg Glu Ser Val Lys Glu Gln Ala Arg Ile Glu Leu
                245                 250                 255
 
gga ctt aag aga ttt ttg tct tct gga gga tat act gct ttt act act   816
Gly Leu Lys Arg Phe Leu Ser Ser Gly Gly Tyr Thr Ala Phe Thr Thr
            260                 265                 270
 
act ttt gag gat ttg cat ggt atg aaa caa ttg cca gga tta gcc gtt   864
Thr Phe Glu Asp Leu His Gly Met Lys Gln Leu Pro Gly Leu Ala Val
        275                 280                 285
 
caa aga ttg atg gct gaa gga tat gga ttc ggt ggg gaa gga gat tgg   912
Gln Arg Leu Met Ala Glu Gly Tyr Gly Phe Gly Gly Glu Gly Asp Trp
    290                 295                 300
 
aaa act gca gca ttg gtt aga atg atg aaa atg atg gca ggt ggt aaa   960
Lys Thr Ala Ala Leu Val Arg Met Met Lys Met Met Ala Gly Gly Lys
305                 310                 315                 320
 
gaa act tct ttt atg gaa gat tat act tat cat ttt gag cca ggt aat   1008
Glu Thr Ser Phe Met Glu Asp Tyr Thr Tyr His Phe Glu Pro Gly Asn
                325                 330                 335
 
gaa atg att ttg gga tct cac atg tta gaa gtt tgt cca tct att gct   1056
Glu Met Ile Leu Gly Ser His Met Leu Glu Val Cys Pro Ser Ile Ala
            340                 345                 350
 
gaa cat aaa cct aga ata gaa gtt cat cca ttg tct atg gga gct aaa   1104
Glu His Lys Pro Arg Ile Glu Val His Pro Leu Ser Met Gly Ala Lys
        355                 360                 365
 
gat gat cca gct aga ctt gtt ttt gat gga att gcc ggt cct gct gtt   1152
Asp Asp Pro Ala Arg Leu Val Phe Asp Gly Ile Ala Gly Pro Ala Val
    370                 375                 380
 
aat gtt tct tta att gat ttg gga gga agg ttt aga ttg gtt att aat   1200
Asn Val Ser Leu Ile Asp Leu Gly Gly Arg Phe Arg Leu Val Ile Asn
385                 390                 395                 400
 
aaa gtt gaa gcc gtc aaa gtt cca cat gat atg cca aat ttg cct gtt   1248
Lys Val Glu Ala Val Lys Val Pro His Asp Met Pro Asn Leu Pro Val
                405                 410                 415
 
gct aga gtt ttg tgg aag cct caa cca tct tta aga act tct gct gag   1296
Ala Arg Val Leu Trp Lys Pro Gln Pro Ser Leu Arg Thr Ser Ala Glu
            420                 425                 430
 
gca tgg att ctt gct ggt gga gct cat cat act tgt ttg tct tat caa   1344
Ala Trp Ile Leu Ala Gly Gly Ala His His Thr Cys Leu Ser Tyr Gln
        435                 440                 445
 
ttg act gca gaa caa atg tta gat tgg gct gaa atg tct gga att gaa   1392
Leu Thr Ala Glu Gln Met Leu Asp Trp Ala Glu Met Ser Gly Ile Glu
    450                 455                 460
 
gca gtc ttg att aat aga gac act act att tta aac ttg aga aat gaa   1440
Ala Val Leu Ile Asn Arg Asp Thr Thr Ile Leu Asn Leu Arg Asn Glu
465                 470                 475                 480
 
ctg aag tgg agc gaa gca gcc tat aga ttg aga aaa ttt               1479
Leu Lys Trp Ser Glu Ala Ala Tyr Arg Leu Arg Lys Phe
                485                 490
 

<210> 308
<211> 493
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in P. pastoris

<400> 308
Met Ile Gln Ala Lys Thr His Val Phe Trp Phe Val Thr Gly Ser Gln
 1               5                  10                  15      
His Leu Tyr Gly Glu Glu Ala Val Gln Glu Val Glu Glu His Ser Lys
            20                  25                  30          
Met Ile Cys Asn Gly Leu Asn Asp Gly Asp Leu Arg Phe Gln Val Glu
        35                  40                  45              
Tyr Lys Ala Val Ala Thr Ser Leu Asp Gly Val Arg Lys Leu Phe Glu
    50                  55                  60                  
Glu Ala Asn Arg Asp Glu Glu Cys Ala Gly Ile Ile Thr Trp Met His
65                  70                  75                  80  
Thr Phe Ser Pro Ala Lys Met Trp Ile Pro Gly Leu Ser Glu Leu Asn
                85                  90                  95      
Lys Pro Leu Leu His Phe His Thr Gln Phe Asn Arg Asp Ile Pro Trp
            100                 105                 110         
Asp Lys Ile Asp Met Asp Phe Met Asn Ile Asn Gln Ser Ala His Gly
        115                 120                 125             
Asp Arg Glu Tyr Gly Phe Ile Gly Ala Arg Leu Gly Ile Pro Arg Lys
    130                 135                 140                 
Val Ile Ala Gly Tyr Trp Glu Asp Arg Glu Val Lys Arg Ser Ile Asp
145                 150                 155                 160 
Lys Trp Met Ser Ala Ala Val Ala Tyr Ile Glu Ser Arg His Ile Lys
                165                 170                 175     
Val Ala Arg Phe Gly Asp Asn Met Arg Asn Val Ala Val Thr Glu Gly
            180                 185                 190         
Asp Lys Ile Glu Ala Gln Ile Gln Leu Gly Trp Ser Val Asp Gly Tyr
        195                 200                 205             
Gly Ile Gly Asp Leu Val Thr Glu Ile Asn Ala Val Ser Glu Gln Ser
    210                 215                 220                 
Leu Ser Glu Leu Ile Ser Glu Tyr Glu Glu Leu Tyr Glu Trp Pro Glu
225                 230                 235                 240 
Gly Glu Ala Ala Arg Glu Ser Val Lys Glu Gln Ala Arg Ile Glu Leu
                245                 250                 255     
Gly Leu Lys Arg Phe Leu Ser Ser Gly Gly Tyr Thr Ala Phe Thr Thr
            260                 265                 270         
Thr Phe Glu Asp Leu His Gly Met Lys Gln Leu Pro Gly Leu Ala Val
        275                 280                 285             
Gln Arg Leu Met Ala Glu Gly Tyr Gly Phe Gly Gly Glu Gly Asp Trp
    290                 295                 300                 
Lys Thr Ala Ala Leu Val Arg Met Met Lys Met Met Ala Gly Gly Lys
305                 310                 315                 320 
Glu Thr Ser Phe Met Glu Asp Tyr Thr Tyr His Phe Glu Pro Gly Asn
                325                 330                 335     
Glu Met Ile Leu Gly Ser His Met Leu Glu Val Cys Pro Ser Ile Ala
            340                 345                 350         
Glu His Lys Pro Arg Ile Glu Val His Pro Leu Ser Met Gly Ala Lys
        355                 360                 365             
Asp Asp Pro Ala Arg Leu Val Phe Asp Gly Ile Ala Gly Pro Ala Val
    370                 375                 380                 
Asn Val Ser Leu Ile Asp Leu Gly Gly Arg Phe Arg Leu Val Ile Asn
385                 390                 395                 400 
Lys Val Glu Ala Val Lys Val Pro His Asp Met Pro Asn Leu Pro Val
                405                 410                 415     
Ala Arg Val Leu Trp Lys Pro Gln Pro Ser Leu Arg Thr Ser Ala Glu
            420                 425                 430         
Ala Trp Ile Leu Ala Gly Gly Ala His His Thr Cys Leu Ser Tyr Gln
        435                 440                 445             
Leu Thr Ala Glu Gln Met Leu Asp Trp Ala Glu Met Ser Gly Ile Glu
    450                 455                 460                 
Ala Val Leu Ile Asn Arg Asp Thr Thr Ile Leu Asn Leu Arg Asn Glu
465                 470                 475                 480 
Leu Lys Trp Ser Glu Ala Ala Tyr Arg Leu Arg Lys Phe
                485                 490             


<210> 309
<211> 1479
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in I. lactis

<220> 
<221> CDS            
<222> (1)...(1479)

<400> 309
atg att cag gct aaa act cat gtt ttc tgg ttc gtt act ggt tct caa   48
Met Ile Gln Ala Lys Thr His Val Phe Trp Phe Val Thr Gly Ser Gln
 1               5                   10                  15
 
cat ttg tat ggt gaa gaa gct gtt caa gaa gtt gaa gaa cat tct aaa   96
His Leu Tyr Gly Glu Glu Ala Val Gln Glu Val Glu Glu His Ser Lys
             20                  25                  30
 
atg att tgt aat ggt tta aac gat ggt gat ttg aga ttt caa gtt gaa   144
Met Ile Cys Asn Gly Leu Asn Asp Gly Asp Leu Arg Phe Gln Val Glu
         35                  40                  45
 
tat aaa gct gtt gct act tct tta gat ggt gtt aga aaa ttg ttc gaa   192
Tyr Lys Ala Val Ala Thr Ser Leu Asp Gly Val Arg Lys Leu Phe Glu
     50                  55                  60
 
gaa gca aat aga gat gaa gaa tgt gct ggt ata att act tgg atg cat   240
Glu Ala Asn Arg Asp Glu Glu Cys Ala Gly Ile Ile Thr Trp Met His
 65                  70                  75                  80
 
act ttc tca cca gct aaa atg tgg att cca ggt ttg tct gaa tta aac   288
Thr Phe Ser Pro Ala Lys Met Trp Ile Pro Gly Leu Ser Glu Leu Asn
                 85                  90                  95
 
aaa cca ttg ttg cat ttt cac act caa ttc aat aga gat ata cca tgg   336
Lys Pro Leu Leu His Phe His Thr Gln Phe Asn Arg Asp Ile Pro Trp
            100                 105                 110
 
gat aag att gat atg gat ttc atg aat att aat caa tct gct cat ggt   384
Asp Lys Ile Asp Met Asp Phe Met Asn Ile Asn Gln Ser Ala His Gly
        115                 120                 125
 
gat aga gaa tat ggt ttc att ggt gct aga ttg gga atc cct aga aaa   432
Asp Arg Glu Tyr Gly Phe Ile Gly Ala Arg Leu Gly Ile Pro Arg Lys
    130                 135                 140
 
gtt att gct ggt tat tgg gaa gat aga gaa gtt aaa aga tct att gat   480
Val Ile Ala Gly Tyr Trp Glu Asp Arg Glu Val Lys Arg Ser Ile Asp
145                 150                 155                 160
 
aag tgg atg tct gct gct gtc gcc tat att gaa tct agg cat att aaa   528
Lys Trp Met Ser Ala Ala Val Ala Tyr Ile Glu Ser Arg His Ile Lys
                165                 170                 175
 
gtt gct aga ttc ggt gat aat atg aga aat gtt gct gtt act gaa ggt   576
Val Ala Arg Phe Gly Asp Asn Met Arg Asn Val Ala Val Thr Glu Gly
            180                 185                 190
 
gac aaa att gaa gct caa att cag ttg ggt tgg tct gtt gat ggt tat   624
Asp Lys Ile Glu Ala Gln Ile Gln Leu Gly Trp Ser Val Asp Gly Tyr
        195                 200                 205
 
gga att ggt gat ctg gtt act gaa att aat gct gtt tct gag caa tct   672
Gly Ile Gly Asp Leu Val Thr Glu Ile Asn Ala Val Ser Glu Gln Ser
    210                 215                 220
 
tta tct gaa ttg att tct gaa tat gaa gaa ttg tat gaa tgg cca gaa   720
Leu Ser Glu Leu Ile Ser Glu Tyr Glu Glu Leu Tyr Glu Trp Pro Glu
225                 230                 235                 240
 
ggt gag gca gca agg gaa tct gtt aaa gaa caa gct aga att gaa ttg   768
Gly Glu Ala Ala Arg Glu Ser Val Lys Glu Gln Ala Arg Ile Glu Leu
                245                 250                 255
 
ggt tta aaa aga ttc ttg tct tct ggt ggt tat act gct ttc act act   816
Gly Leu Lys Arg Phe Leu Ser Ser Gly Gly Tyr Thr Ala Phe Thr Thr
            260                 265                 270
 
act ttc gaa gat ttg cat ggt atg aaa caa ttg cca ggt cta gcg gtt   864
Thr Phe Glu Asp Leu His Gly Met Lys Gln Leu Pro Gly Leu Ala Val
        275                 280                 285
 
caa aga ttg atg gct gaa ggc tat ggt ttc gga ggg gaa gga gat tgg   912
Gln Arg Leu Met Ala Glu Gly Tyr Gly Phe Gly Gly Glu Gly Asp Trp
    290                 295                 300
 
aaa act gcc gca ttg gtt aga atg atg aaa atg atg gcg ggt gga aag   960
Lys Thr Ala Ala Leu Val Arg Met Met Lys Met Met Ala Gly Gly Lys
305                 310                 315                 320
 
gaa act tct ttc atg gaa gat tat act tat cac ttc gaa cct ggt aat   1008
Glu Thr Ser Phe Met Glu Asp Tyr Thr Tyr His Phe Glu Pro Gly Asn
                325                 330                 335
 
gaa atg att ttg ggt tct cac atg ttg gaa gtt tgt cca tct att gct   1056
Glu Met Ile Leu Gly Ser His Met Leu Glu Val Cys Pro Ser Ile Ala
            340                 345                 350
 
gaa cat aaa cca agg att gaa gtt cat cca ttg tct atg ggt gct aaa   1104
Glu His Lys Pro Arg Ile Glu Val His Pro Leu Ser Met Gly Ala Lys
        355                 360                 365
 
gat gat cca gct aga ctc gtt ttc gat gga att gca gga cca gca gtg   1152
Asp Asp Pro Ala Arg Leu Val Phe Asp Gly Ile Ala Gly Pro Ala Val
    370                 375                 380
 
aat gtt tca ttg att gat ttg ggt ggt agg ttc aga ttg gtt att aat   1200
Asn Val Ser Leu Ile Asp Leu Gly Gly Arg Phe Arg Leu Val Ile Asn
385                 390                 395                 400
 
aaa gtt gaa gcc gtt aaa gtt cca cat gat atg cca aat ttg cct gtt   1248
Lys Val Glu Ala Val Lys Val Pro His Asp Met Pro Asn Leu Pro Val
                405                 410                 415
 
gcc aga gtt ttg tgg aaa cca caa cca tct tta aga act tct gct gag   1296
Ala Arg Val Leu Trp Lys Pro Gln Pro Ser Leu Arg Thr Ser Ala Glu
            420                 425                 430
 
gct tgg att ctc gct gga gga gct cat cat act tgt ttg tct tat caa   1344
Ala Trp Ile Leu Ala Gly Gly Ala His His Thr Cys Leu Ser Tyr Gln
        435                 440                 445
 
ttg aca gcc gaa caa atg tta gat tgg gcc gaa atg tct ggt ata gaa   1392
Leu Thr Ala Glu Gln Met Leu Asp Trp Ala Glu Met Ser Gly Ile Glu
    450                 455                 460
 
gcg gtg ttg att aat aga gac act act att tta aat ttg aga aat gaa   1440
Ala Val Leu Ile Asn Arg Asp Thr Thr Ile Leu Asn Leu Arg Asn Glu
465                 470                 475                 480
 
tta aag tgg tct gaa gca gcg tat aga ttg aga aaa ttc               1479
Leu Lys Trp Ser Glu Ala Ala Tyr Arg Leu Arg Lys Phe
                485                 490
 

<210> 310
<211> 493
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in K. lactis

<400> 310
Met Ile Gln Ala Lys Thr His Val Phe Trp Phe Val Thr Gly Ser Gln
 1               5                  10                  15      
His Leu Tyr Gly Glu Glu Ala Val Gln Glu Val Glu Glu His Ser Lys
            20                  25                  30          
Met Ile Cys Asn Gly Leu Asn Asp Gly Asp Leu Arg Phe Gln Val Glu
        35                  40                  45              
Tyr Lys Ala Val Ala Thr Ser Leu Asp Gly Val Arg Lys Leu Phe Glu
    50                  55                  60                  
Glu Ala Asn Arg Asp Glu Glu Cys Ala Gly Ile Ile Thr Trp Met His
65                  70                  75                  80  
Thr Phe Ser Pro Ala Lys Met Trp Ile Pro Gly Leu Ser Glu Leu Asn
                85                  90                  95      
Lys Pro Leu Leu His Phe His Thr Gln Phe Asn Arg Asp Ile Pro Trp
            100                 105                 110         
Asp Lys Ile Asp Met Asp Phe Met Asn Ile Asn Gln Ser Ala His Gly
        115                 120                 125             
Asp Arg Glu Tyr Gly Phe Ile Gly Ala Arg Leu Gly Ile Pro Arg Lys
    130                 135                 140                 
Val Ile Ala Gly Tyr Trp Glu Asp Arg Glu Val Lys Arg Ser Ile Asp
145                 150                 155                 160 
Lys Trp Met Ser Ala Ala Val Ala Tyr Ile Glu Ser Arg His Ile Lys
                165                 170                 175     
Val Ala Arg Phe Gly Asp Asn Met Arg Asn Val Ala Val Thr Glu Gly
            180                 185                 190         
Asp Lys Ile Glu Ala Gln Ile Gln Leu Gly Trp Ser Val Asp Gly Tyr
        195                 200                 205             
Gly Ile Gly Asp Leu Val Thr Glu Ile Asn Ala Val Ser Glu Gln Ser
    210                 215                 220                 
Leu Ser Glu Leu Ile Ser Glu Tyr Glu Glu Leu Tyr Glu Trp Pro Glu
225                 230                 235                 240 
Gly Glu Ala Ala Arg Glu Ser Val Lys Glu Gln Ala Arg Ile Glu Leu
                245                 250                 255     
Gly Leu Lys Arg Phe Leu Ser Ser Gly Gly Tyr Thr Ala Phe Thr Thr
            260                 265                 270         
Thr Phe Glu Asp Leu His Gly Met Lys Gln Leu Pro Gly Leu Ala Val
        275                 280                 285             
Gln Arg Leu Met Ala Glu Gly Tyr Gly Phe Gly Gly Glu Gly Asp Trp
    290                 295                 300                 
Lys Thr Ala Ala Leu Val Arg Met Met Lys Met Met Ala Gly Gly Lys
305                 310                 315                 320 
Glu Thr Ser Phe Met Glu Asp Tyr Thr Tyr His Phe Glu Pro Gly Asn
                325                 330                 335     
Glu Met Ile Leu Gly Ser His Met Leu Glu Val Cys Pro Ser Ile Ala
            340                 345                 350         
Glu His Lys Pro Arg Ile Glu Val His Pro Leu Ser Met Gly Ala Lys
        355                 360                 365             
Asp Asp Pro Ala Arg Leu Val Phe Asp Gly Ile Ala Gly Pro Ala Val
    370                 375                 380                 
Asn Val Ser Leu Ile Asp Leu Gly Gly Arg Phe Arg Leu Val Ile Asn
385                 390                 395                 400 
Lys Val Glu Ala Val Lys Val Pro His Asp Met Pro Asn Leu Pro Val
                405                 410                 415     
Ala Arg Val Leu Trp Lys Pro Gln Pro Ser Leu Arg Thr Ser Ala Glu
            420                 425                 430         
Ala Trp Ile Leu Ala Gly Gly Ala His His Thr Cys Leu Ser Tyr Gln
        435                 440                 445             
Leu Thr Ala Glu Gln Met Leu Asp Trp Ala Glu Met Ser Gly Ile Glu
    450                 455                 460                 
Ala Val Leu Ile Asn Arg Asp Thr Thr Ile Leu Asn Leu Arg Asn Glu
465                 470                 475                 480 
Leu Lys Trp Ser Glu Ala Ala Tyr Arg Leu Arg Lys Phe
                485                 490             


<210> 311
<211> 1479
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in Z. mobilis

<220> 
<221> CDS            
<222> (1)...(1479)

<400> 311
atg att cag gcc aaa acc cac gtt ttc tgg ttt gtt acc ggt tct cag   48
Met Ile Gln Ala Lys Thr His Val Phe Trp Phe Val Thr Gly Ser Gln
 1               5                   10                  15
 
cat ttg tat ggt gaa gaa gct gtt cag gaa gtt gaa gaa cat tct aaa   96
His Leu Tyr Gly Glu Glu Ala Val Gln Glu Val Glu Glu His Ser Lys
             20                  25                  30
 
atg att tgt aat ggt ttg aat gat ggt gat ttg cgt ttt cag gtt gaa   144
Met Ile Cys Asn Gly Leu Asn Asp Gly Asp Leu Arg Phe Gln Val Glu
         35                  40                  45
 
tat aaa gcc gtt gcc acg agc ttg gac ggt gtt cgt aaa ttg ttt gaa   192
Tyr Lys Ala Val Ala Thr Ser Leu Asp Gly Val Arg Lys Leu Phe Glu
     50                  55                  60
 
gag gct aat cgt gat gaa gaa tgt gcc ggg atc att acc tgg atg cat   240
Glu Ala Asn Arg Asp Glu Glu Cys Ala Gly Ile Ile Thr Trp Met His
 65                  70                  75                  80
 
acc ttt tct ccg gcc aaa atg tgg att ccg ggt ttg agc gaa ttg aat   288
Thr Phe Ser Pro Ala Lys Met Trp Ile Pro Gly Leu Ser Glu Leu Asn
                 85                  90                  95
 
aaa ccg ttg ttg cat ttt cat acc cag ttt aat cgt gat atc ccg tgg   336
Lys Pro Leu Leu His Phe His Thr Gln Phe Asn Arg Asp Ile Pro Trp
            100                 105                 110
 
gat aaa att gat atg gat ttt atg aat att aat cag tct gcc cat ggt   384
Asp Lys Ile Asp Met Asp Phe Met Asn Ile Asn Gln Ser Ala His Gly
        115                 120                 125
 
gat cgt gaa tat ggt ttt att ggt gcc cgc ttg ggt ata ccg cgt aaa   432
Asp Arg Glu Tyr Gly Phe Ile Gly Ala Arg Leu Gly Ile Pro Arg Lys
    130                 135                 140
 
gtc att gct ggt tat tgg gaa gat cgt gaa gtt aaa cgt tct att gat   480
Val Ile Ala Gly Tyr Trp Glu Asp Arg Glu Val Lys Arg Ser Ile Asp
145                 150                 155                 160
 
aaa tgg atg tct gcc gcc gtc gcg tac att gaa tct cgt cat att aaa   528
Lys Trp Met Ser Ala Ala Val Ala Tyr Ile Glu Ser Arg His Ile Lys
                165                 170                 175
 
gtt gct cgt ttt ggt gat aat atg cgt aat gtt gcc gtt aca gaa ggt   576
Val Ala Arg Phe Gly Asp Asn Met Arg Asn Val Ala Val Thr Glu Gly
            180                 185                 190
 
gat aaa att gaa gct cag att cag ttg ggt tgg tct gtt gat ggt tat   624
Asp Lys Ile Glu Ala Gln Ile Gln Leu Gly Trp Ser Val Asp Gly Tyr
        195                 200                 205
 
ggc att ggt gat ttg gtt acc gaa att aat gcc gtc tct gaa cag tct   672
Gly Ile Gly Asp Leu Val Thr Glu Ile Asn Ala Val Ser Glu Gln Ser
    210                 215                 220
 
ttg tct gaa ttg att tct gaa tat gaa gaa ttg tat gaa tgg ccc gag   720
Leu Ser Glu Leu Ile Ser Glu Tyr Glu Glu Leu Tyr Glu Trp Pro Glu
225                 230                 235                 240
 
ggc gag gcc gct cgt gaa tct gtt aaa gaa cag gct cgt att gaa ttg   768
Gly Glu Ala Ala Arg Glu Ser Val Lys Glu Gln Ala Arg Ile Glu Leu
                245                 250                 255
 
ggt ttg aaa cgt ttt ctt tct tct ggt ggt tat aca gct ttc acc acc   816
Gly Leu Lys Arg Phe Leu Ser Ser Gly Gly Tyr Thr Ala Phe Thr Thr
            260                 265                 270
 
acc ttt gaa gat ttg cat ggt atg aaa cag ttg cca ggt tta gcc gtt   864
Thr Phe Glu Asp Leu His Gly Met Lys Gln Leu Pro Gly Leu Ala Val
        275                 280                 285
 
cag cgt cta atg gct gag gga tat ggt ttt ggt ggc gaa gga gat tgg   912
Gln Arg Leu Met Ala Glu Gly Tyr Gly Phe Gly Gly Glu Gly Asp Trp
    290                 295                 300
 
aaa acc gct gcg ttg gtt cgt atg atg aaa atg atg gct ggc ggt aaa   960
Lys Thr Ala Ala Leu Val Arg Met Met Lys Met Met Ala Gly Gly Lys
305                 310                 315                 320
 
gaa acc tct ttt atg gaa gat tat acc tac cat ttt gaa ccg ggt aat   1008
Glu Thr Ser Phe Met Glu Asp Tyr Thr Tyr His Phe Glu Pro Gly Asn
                325                 330                 335
 
gaa atg att ttg ggt tct cac atg ttg gaa gtt tgt ccg tct att gcc   1056
Glu Met Ile Leu Gly Ser His Met Leu Glu Val Cys Pro Ser Ile Ala
            340                 345                 350
 
gaa cat aaa ccg aga att gaa gtt cat ccg ttg tct atg ggt gcc aaa   1104
Glu His Lys Pro Arg Ile Glu Val His Pro Leu Ser Met Gly Ala Lys
        355                 360                 365
 
gat gat ccg gct cgg ttg gtt ttt gat ggg atc gcg ggt cct gct gtt   1152
Asp Asp Pro Ala Arg Leu Val Phe Asp Gly Ile Ala Gly Pro Ala Val
    370                 375                 380
 
aat gtt tct ttg att gat ttg ggt ggt cgt ttt cgt ctg gtc att aat   1200
Asn Val Ser Leu Ile Asp Leu Gly Gly Arg Phe Arg Leu Val Ile Asn
385                 390                 395                 400
 
aaa gtt gag gca gtc aaa gtt ccg cat gat atg ccg aat ttg cct gtt   1248
Lys Val Glu Ala Val Lys Val Pro His Asp Met Pro Asn Leu Pro Val
                405                 410                 415
 
gct aga gtt ttg tgg aaa ccg caa ccc tct ttg cgc acc tct gct gaa   1296
Ala Arg Val Leu Trp Lys Pro Gln Pro Ser Leu Arg Thr Ser Ala Glu
            420                 425                 430
 
gcg tgg att ctt gct gga ggt gct cat cat acc tgt ttg tct tat cag   1344
Ala Trp Ile Leu Ala Gly Gly Ala His His Thr Cys Leu Ser Tyr Gln
        435                 440                 445
 
ttg aca gct gag cag atg ttg gac tgg gct gaa atg agt gga atc gaa   1392
Leu Thr Ala Glu Gln Met Leu Asp Trp Ala Glu Met Ser Gly Ile Glu
    450                 455                 460
 
gct gtt ttg att aat cgt gat acc acc atc ctg aat ttg cgt aac gaa   1440
Ala Val Leu Ile Asn Arg Asp Thr Thr Ile Leu Asn Leu Arg Asn Glu
465                 470                 475                 480
 
ttg aaa tgg tct gaa gct gcc tac cgt ttg cgt aaa ttt               1479
Leu Lys Trp Ser Glu Ala Ala Tyr Arg Leu Arg Lys Phe
                485                 490
 

<210> 312
<211> 493
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in Z. mobilis

<400> 312
Met Ile Gln Ala Lys Thr His Val Phe Trp Phe Val Thr Gly Ser Gln
 1               5                  10                  15      
His Leu Tyr Gly Glu Glu Ala Val Gln Glu Val Glu Glu His Ser Lys
            20                  25                  30          
Met Ile Cys Asn Gly Leu Asn Asp Gly Asp Leu Arg Phe Gln Val Glu
        35                  40                  45              
Tyr Lys Ala Val Ala Thr Ser Leu Asp Gly Val Arg Lys Leu Phe Glu
    50                  55                  60                  
Glu Ala Asn Arg Asp Glu Glu Cys Ala Gly Ile Ile Thr Trp Met His
65                  70                  75                  80  
Thr Phe Ser Pro Ala Lys Met Trp Ile Pro Gly Leu Ser Glu Leu Asn
                85                  90                  95      
Lys Pro Leu Leu His Phe His Thr Gln Phe Asn Arg Asp Ile Pro Trp
            100                 105                 110         
Asp Lys Ile Asp Met Asp Phe Met Asn Ile Asn Gln Ser Ala His Gly
        115                 120                 125             
Asp Arg Glu Tyr Gly Phe Ile Gly Ala Arg Leu Gly Ile Pro Arg Lys
    130                 135                 140                 
Val Ile Ala Gly Tyr Trp Glu Asp Arg Glu Val Lys Arg Ser Ile Asp
145                 150                 155                 160 
Lys Trp Met Ser Ala Ala Val Ala Tyr Ile Glu Ser Arg His Ile Lys
                165                 170                 175     
Val Ala Arg Phe Gly Asp Asn Met Arg Asn Val Ala Val Thr Glu Gly
            180                 185                 190         
Asp Lys Ile Glu Ala Gln Ile Gln Leu Gly Trp Ser Val Asp Gly Tyr
        195                 200                 205             
Gly Ile Gly Asp Leu Val Thr Glu Ile Asn Ala Val Ser Glu Gln Ser
    210                 215                 220                 
Leu Ser Glu Leu Ile Ser Glu Tyr Glu Glu Leu Tyr Glu Trp Pro Glu
225                 230                 235                 240 
Gly Glu Ala Ala Arg Glu Ser Val Lys Glu Gln Ala Arg Ile Glu Leu
                245                 250                 255     
Gly Leu Lys Arg Phe Leu Ser Ser Gly Gly Tyr Thr Ala Phe Thr Thr
            260                 265                 270         
Thr Phe Glu Asp Leu His Gly Met Lys Gln Leu Pro Gly Leu Ala Val
        275                 280                 285             
Gln Arg Leu Met Ala Glu Gly Tyr Gly Phe Gly Gly Glu Gly Asp Trp
    290                 295                 300                 
Lys Thr Ala Ala Leu Val Arg Met Met Lys Met Met Ala Gly Gly Lys
305                 310                 315                 320 
Glu Thr Ser Phe Met Glu Asp Tyr Thr Tyr His Phe Glu Pro Gly Asn
                325                 330                 335     
Glu Met Ile Leu Gly Ser His Met Leu Glu Val Cys Pro Ser Ile Ala
            340                 345                 350         
Glu His Lys Pro Arg Ile Glu Val His Pro Leu Ser Met Gly Ala Lys
        355                 360                 365             
Asp Asp Pro Ala Arg Leu Val Phe Asp Gly Ile Ala Gly Pro Ala Val
    370                 375                 380                 
Asn Val Ser Leu Ile Asp Leu Gly Gly Arg Phe Arg Leu Val Ile Asn
385                 390                 395                 400 
Lys Val Glu Ala Val Lys Val Pro His Asp Met Pro Asn Leu Pro Val
                405                 410                 415     
Ala Arg Val Leu Trp Lys Pro Gln Pro Ser Leu Arg Thr Ser Ala Glu
            420                 425                 430         
Ala Trp Ile Leu Ala Gly Gly Ala His His Thr Cys Leu Ser Tyr Gln
        435                 440                 445             
Leu Thr Ala Glu Gln Met Leu Asp Trp Ala Glu Met Ser Gly Ile Glu
    450                 455                 460                 
Ala Val Leu Ile Asn Arg Asp Thr Thr Ile Leu Asn Leu Arg Asn Glu
465                 470                 475                 480 
Leu Lys Trp Ser Glu Ala Ala Tyr Arg Leu Arg Lys Phe
                485                 490             

